IMMOBILIZED CHELATOR FOR EXTRACORPOREAL LEAD REMOVAL

Information

  • Research Project
  • 3502129
  • ApplicationId
    3502129
  • Core Project Number
    R43HL047662
  • Full Project Number
    1R43HL047662-01
  • Serial Number
    47662
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/1/1991 - 33 years ago
  • Project End Date
    2/29/1992 - 32 years ago
  • Program Officer Name
  • Budget Start Date
    9/1/1991 - 33 years ago
  • Budget End Date
    2/29/1992 - 32 years ago
  • Fiscal Year
    1991
  • Support Year
    1
  • Suffix
  • Award Notice Date
    8/15/1991 - 33 years ago
Organizations

IMMOBILIZED CHELATOR FOR EXTRACORPOREAL LEAD REMOVAL

Recent reports estimate the number of children with lead intoxication at 230,000, the number of industrial workers with lead poisoning at 530,000. These number create a medical problem of alarming magnitude, because treatment with available chelators has serious side-effects. Even the chelator-lead complexes that for in the blood during treatment are damaging the kidneys during elimination. We have developed a polysulfone hollow-fiber device with immobilized chelators, for the extracorporeal removal of lead from blood and subsequently from storage sites. Since the chelator is immobilized the chelation process occurs outside of the circulation, and toxicity of lead and lead-chelator complex is eliminated. The goal in the Phase I studies is to explore the feasibility of developing a lead-chelator device of clinical significance. The following studies will be conducted: Chelator functions will be synthesized on various supports and lead binding capacity tested Colloidal suspensions will be prepared from these chelators and tested for capacity and lead specificity. By step- wise selection, the most promising agents will be loaded into hollow fiber cartridges and evaluated for capacity, specificity, and kinetics of lead removal. Results will help select the optimal chelator to develop for a prototype for clinical use with Phase II support.

IC Name
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
  • Activity
    R43
  • Administering IC
    HL
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    837
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    SSS
  • Study Section Name
  • Organization Name
    HEMEX, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    BUFFALO
  • Organization State
    NY
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    14209
  • Organization District
    UNITED STATES