Claims
- 1. A method for inducing an immune response against an endogenous molecule in a mammalian subject, comprising administering to the ear of said subject an effective amount of a vaccine composition comprising an immunogen derived from said molecule, and a pharmaceutically acceptable vehicle, wherein said vaccine composition is capable of inducing an immune response against said molecule.
- 2. The method of claim 1, wherein the endogenous molecule is a hormone.
- 3. The method of claim 2, wherein the hormone is GnRH.
- 4. The method of claim 1, wherein the endogenous molecule is a hormone receptor.
- 5. The method of claim 1, wherein the vaccine composition is administered to the subject via subcutaneous delivery into the pinna of said subject's ear.
- 6. The method of claim 1, wherein the vaccine composition is administered to the subject via intradermal delivery into the pinna of said subject's ear.
- 7. The method of claim 1, wherein the vaccine composition is administered in more than one dose.
- 8. The method of claim 1, wherein the vaccine composition comprises a polypeptide immunogen linked to a carrier molecule.
- 9. The method of claim 1, wherein the vaccine composition further comprises an adjuvant.
- 10. The method of claim 9, wherein the adjuvant is an oil-in-water formulation.
- 11. The method of claim 1, wherein the vaccine composition is administered with a needleless or jet injector device.
- 12. The method of claim 1, wherein the vaccine composition is administered in solid form.
- 13. The method of claim 12, wherein the vaccine composition is in solid, particulate form.
- 14. The method of claim 12, wherein the vaccine composition is administered as a solid dose implant.
- 15. The method of claim 1, wherein the vaccine composition comprises a nucleic acid molecule which encodes said immunogen.
- 16. The method of claim 1, wherein the mammalian subject is bovine.
- 17. The method of claim 1, wherein the mammalian subject is porcine.
- 18. A method for delivering a selected endogenous immunogen to a mammalian subject, comprising administering to the ear of said subject an effective amount of a vaccine composition comprising the endogenous immunogen and a pharmaceutically acceptable vehicle.
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application is related to provisional patent application serial no. 60/036,883, filed Feb. 5, 1997, from which priority is claimed under 35 U.S.C. §119 (e) (1) and which is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
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60036883 |
Feb 1997 |
US |