Claims
- 1. A method of treating metastatic tumors in a subject, which method comprises:
administering to a subject afflicted by metastatic tumors effective amounts of one or more photosensitizer and one or more immuno-adjuvant, and irradiating said subject with light absorbed by said one or more photosensitizer, wherein said method is photochemical mediated photodynamic therapy (PDT).
- 2. A method of preventing or inhibiting the development of metastatic tumors in a subject, which method comprises:
administering to a subject at risk for developing metastatic tumors effective amounts of one or more photosensitizer and one or more immuno-adjuvant, and irradiating said subject with light absorbed by said one or more photosensitizer.
- 3. A method of treating a primary tumor in a subject, which method comprises:
administering to a subject clinically diagnosed with a primary tumor effective amounts of one or more photosensitizer and one or more immuno-adjuvant, and irradiating said subject with light absorbed by said one or more photosensitizer.
- 4. The method of claim 2 wherein said subject has previously undergone cancer or tumor therapy.
- 5. The method of claim 1 wherein said effective amount of one or more photosensitizer is in the range of 0.05 to 10 mg/kg.
- 6. The method of claim 5 wherein said effective amount of one or more photosensitizer is in the range of 0.05 to 1 mg/kg.
- 7. The method of claim 5 wherein said effective amount of one or more photosensitizer is in the range of 1 to 10 mg/kg.
- 8. The method of claim 1 wherein said one or more photosensitizer is administered intravenously and said one or more immuno-adjuvant is administered by injection into tumors after irradiation.
- 9. The method of claim 1 wherein said irradiation is localized to the tumors.
- 10. The method of claim 2 wherein said one or more photosensitizer is administered intravenously or intratumorally.
- 11. The method of claim 1 wherein said one or more photosensitizer is administered, and the subject irradiated, before administration of said one or more immuno-adjuvant.
- 12. The method of claim 1 wherein said one or more immuno-adjuvant is administered systemically.
- 13. The method of claim 1 wherein said one or more photosensitizer is a benzoporphyrin derivative (BPD) or a green porphyrin.
- 14. The method of claim 13 wherein the BPD is BPD-MA, EA6, or B3.
- 15. The method of claim 1 further comprising an additional irradiation, before irradiation with light absorbed by said one or more photosensitizer, with light of a wavelength which improves penetration of the absorbed light.
- 16. The method of claim 1 wherein said one or more immuno-adjuvant comprises mycobacterial cell wall skeleton and/or lipid A from a gram negative bacterium.
- 17. The method of claim 16 wherein said lipid A is de-3-O-acylated lipid A.
- 18. The method of claim 8 further comprising additional systemic administration of immuno-adjuvant to said subject.
- 19. The method of claim 18 wherein said additional systemic administration occurs at least from 1-3 times and occurs at an interval of about two weeks.
- 20. The method of claim 1 further comprising at least 1-3 repeats of the administering and irradiating steps.
- 21. The method of claim 14 wherein said BPD is BPD-MA.
- 22. A pharmaceutical composition to treat, prevent, or inhibit the development of, metastatic tumors, said composition comprising:
a photosensitizer and an immuno-adjuvant in amounts effective to treat, prevent, or inhibit the development of, metastatic tumors, and a pharmaceutically acceptable carrier or excipient.
- 23. The composition of claim 22 wherein the photosensitizer is a BPD or a green porphyrin.
- 24. The composition of claim 23 which is a liposomal formulation.
- 25. The composition of claim 23 wherein the BPD is BPD-MA, EA6, or B3.
- 26. The composition of claim 23 wherein said immuno-adjuvant comprises mycobacterial cell wall skeleton and lipid A from a gram negative bacterium.
- 27. The composition of claim 26 wherein said lipid A is de-3-O-acylated lipid A.
RELATED APPLICATIONS
[0001] This application is a continuation-in-part application of U.S. patent application Ser. No. 09/556,833, filed Apr. 21, 2000, which claims benefit of priority from U.S. Provisional Application 60/130,519, filed Apr. 23, 1999, both of which are hereby incorporated by reference as if fully set forth.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60130519 |
Apr 1999 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09556833 |
Apr 2000 |
US |
Child |
09756687 |
Jan 2001 |
US |