IMMUNOISOLATED CELL TRANSPLANTATION FOR PARKINSON'S

Information

• Research Project
• 2267317

• ApplicationId

  2267317

• Core Project Number

  R43NS028992

• Full Project Number

  1R43NS028992-01

• Serial Number

  28992

• FOA Number

• Sub Project Id

• Project Start Date

  9/1/1990 - 34 years ago

• Project End Date

  2/28/1991 - 33 years ago

• Program Officer Name

• Budget Start Date

  9/1/1990 - 34 years ago

• Budget End Date

  2/28/1991 - 33 years ago

• Fiscal Year

  1990

• Support Year

  1

• Suffix

• Award Notice Date

  8/29/1990 - 34 years ago

Organizations

• CYTOTHERAPEUTICS, INC

Striatal transplantation of neurotransmitter cells, immunoisolated within a permselective polymer membrane capsule, represents a novel approach to the treatment of Parkinson's disease. The technique has had promising results in several rodent models, and primate studies are underway. The overall objective of our research is to complete the developments necessary for widespread medical acceptance of immunoisolated cellular transplantation in the treatment of neural diseases. One unachieved prerequisite to such acceptance is unequivocal demonstration of capsule integrity and complete segregation of the foreign material from the host. Accordingly, the specific objective of this proposal is to develop and validate an in vitro assay of individual capsule integrity based upon antibody-mediated complement lysis of encapsulated PC12 cells.

IC Name

• Activity

  R43

• Administering IC

  NS

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  853

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  BPO

• Study Section Name

  Biopsychology Study Section

• Organization Name

  CYTOTHERAPEUTICS, INC.

• Organization Department

• Organization DUNS

• Organization City

  PROVIDENCE

• Organization State

  RI

• Organization Country

  UNITED STATES

• Organization Zip Code

  02906

• Organization District

  UNITED STATES