The subject technology relates to the delivery of implantable medical devices and systems for delivering implantable medical devices.
The use of endovascular techniques for the implantation of medical devices for treatment, e.g., by occlusion, of body cavities such as arteries, veins, fallopian tubes or vascular deformities is known in the art. For example, vascular aneurysms can be occluded with an implant that is introduced with a pusher member through a catheter. Once advanced to the treatment site, the implant is inserted into the aneurysm cavity to occlude the aneurysm and then detached from the pusher member.
Detachment of an implant from the pusher member can be problematic. It is essential that the implant form as small a profile as possible to be guided through the fine bore of a catheter and it must be configured to bring about a reliable severance of the implant from the pusher member. Absent a reliable severance of the implant, withdrawal of the pusher member and catheter may cause unintended removal of the implant from the aneurysm or vessel to be occluded, and thus injure and/or rupture of the wall of the aneurysm or vessel.
A thermally activated detachment mechanism can be employed for controllably releasing an implantable medical device from a delivery connection assembly in a reliable, rapid, and accurate manner. Thermally activated detachment mechanisms can have advantages compared to electrolytic detachment systems. For example, severance of implantable medical devices can involve engagement and disengagement by a delivery connection assembly that minimizes a protruding aspect of the medical devices at an engagement region thereof. The delivery connection assembly can be designed to engage the medical device such that, after disengagement, the mechanisms for engagement are removed with the delivery connection assembly. Such an arrangement can facilitate rapid severance and leave a medical device without an end that protrudes as far as would an implant's connection to an electrolytic detachment junction after detachment.
In contrast, electrolytic detachment of an implant can leave a portion of the delivery wire protruding from the implant after detachment, presenting a risk of harm to the surrounding anatomy. Additionally, electrolytic detachment can leave behind debris, such as small particulate matter, that can interfere with MRI imaging during a procedure.
Thermally activated detachment mechanisms also can have advantages compared to mechanical detachment systems. For example, while some mechanical methods for the severance of implants from delivery systems are reliable, mechanical energy must be transmitted (e.g., by rotation of the delivery wire), which may cause the implant to be dislodged out of the correct position. A thermally activated detachment system can avoid the need for transmission of mechanical energy.
The subject technology is illustrated, for example, according to various aspects described below. Various examples of aspects of the subject technology are described as numbered clauses (1, 2, 3, etc.) for convenience. These are provided as examples and do not limit the subject technology.
Clause 1. A delivery system, comprising:
Clause 2. The delivery system of clause 1, wherein each of the arms comprises a longitudinal section extending from the junction to the distal section.
Clause 3. The delivery system of any one of clauses 1-2, wherein the distal sections extend radially outwardly.
Clause 4. The delivery system of any one of clauses 1-3, wherein the distal sections define a maximum outer cross-sectional dimension of a distal region of the pusher device.
Clause 5. The delivery system of any one of clauses 1-4, wherein the arms are of a shape memory material.
Clause 6. The delivery system of any one of clauses 1-5, further comprising a heating element thermally connected to the pusher device.
Clause 7. The delivery system of any one of clauses 1-6, further comprising an electrical circuit thermally connected to the pusher device.
Clause 8. The delivery system of any one of clauses 1-7, wherein the proximal portion of the implant is a circumferentially continuous hub.
Clause 9. The delivery system of any one of clauses 1-8, wherein the proximal portion of the implant is a helical coil.
Clause 10. A method of delivering an implant, the method comprising:
Clause 11. The method of clause 10, wherein the releasing comprises operating a heating element thermally connected to the pusher device.
Clause 12. The method of any one of clauses 10-11, wherein the releasing comprises conducting an electrical current through the pusher device.
Clause 13. The method of any one of clauses 10-12, wherein the releasing comprises retracting the distal sections of the arms proximally from the cavity through the port.
Clause 14. The method of clause 13, wherein the releasing further comprises, while retracting the distal sections of the arms, stabilizing the implant with a catheter housing at least a portion of the pusher device.
Clause 15. The method of any one of clauses 10-14, wherein the releasing comprises articulating the arms with respect to the junction.
Clause 16. A delivery system, comprising:
Clause 17. The delivery system of clause 16, wherein at least a portion of the coil extends distally of an entire length of the proximal portion.
Clause 18. The delivery system of any one of clauses 16-17, wherein the coil is of a shape memory material.
Clause 19. The delivery system of any one of clauses 16-18, further comprising a heating element thermally connected to the pusher device.
Clause 20. The delivery system of any one of clauses 16-19, further comprising an electrical circuit thermally connected to the pusher device.
Clause 21. The delivery system of any one of clauses 16-20, wherein the proximal portion of the implant is a circumferentially continuous hub.
Clause 22. A method of delivering an implant, the method comprising:
Clause 23. The method of clause 22, wherein the releasing comprises operating a heating element thermally connected to the pusher device.
Clause 24. The method of any one of clauses 22-23, wherein the releasing comprises conducting an electrical current through the coil.
Clause 25. The method of any one of clauses 22-24, wherein the releasing comprises retracting the coil proximally from the implant.
Additional features and advantages of the subject technology will be set forth in the description below, and in part will be apparent from the description, or may be learned by practice of the subject technology. The advantages of the subject technology will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
It is to be understood that both the foregoing general description and the following detailed description are exemplifying and explanatory and are intended to provide further explanation of the subject technology as claimed.
The accompanying drawings, which are included to provide further understanding of the subject technology and are incorporated in and constitute a part of this description, illustrate aspects of the subject technology and, together with the specification, serve to explain principles of the subject technology.
The detailed description set forth below is intended as a description of various configurations of the subject technology and is not intended to represent the only configurations in which the subject technology may be practiced. The appended drawings are incorporated herein and constitute a part of the detailed description. The detailed description includes specific details for the purpose of providing a thorough understanding of the subject technology. However, the subject technology may be practiced without these specific details. In some instances, well-known structures and components are shown in block diagram form in order to avoid obscuring the concepts of the subject technology.
An implantable medical device, e.g., a vascular implant, may be positioned using a delivery system 10 such as, for example, the one shown in
A power supply 70 can be coupled to a proximal portion of the positioner 40, for example at the actuator 20. A current can flow from the power supply 70 along a first lead 72 to a location near the implant 95 and along a second lead 74 from the location near the implant 95 to the power supply 70. The power supply 70 may be a direct current power supply, an alternating current power supply, or a power supply switchable between a direct current and an alternating current. A positive terminal of the power supply 70, for example as shown in
According to some embodiments, for example as shown in
The braid ball 92 can be formed from tubular braid stock including a resilient material, such as nitinol, that defines an open volume in an uncompressed/unconstrained state. The size of the implant can be selected to fill an aneurysm when expanded therein. The implant 95 can include a hub 50 and layers 26, 28. The hub can be located at a proximal portion 53 of the implant. The hub 50 can be fixedly attached to the remainder of the implant 95. For example, the hub 50 can grasp braided filaments of the layers 26, 28 of the implant 95. The implant 95 can include the layers 26, 28 at least where impacted by flow at a neck of the aneurysm.
According to some embodiments, the hub 50 can be fixedly attached to the remainder of the implant 95. For example, the hub 50 can grasp braided filaments of the layers 26, 28 of the implant 95. A port 54 can be provided within the hub 50. The port 54 can define a port inner cross-sectional dimension 58. The port inner cross-sectional dimension 58 can be a minimum or maximum inner cross-sectional dimension within a region of the proximal portion 53. For example, a region distal to the hub 50 can include a cavity 96 that defines an inner cross-sectional dimension 98 that is greater than the port inner cross-sectional dimension 58. The hub 50 can further define a hub outer cross-sectional dimension 59. The hub outer cross-sectional dimension 59 can be a minimum or maximum outer cross-sectional dimension within a region of the proximal portion 53. For example, a region distal to the hub 50 can define an outer cross-sectional dimension 57 that is smaller than the hub outer cross-sectional dimension 59. The port 54 or an outer surface of the hub 50 can accept the implant 95. Delivery system construction and further optional details of the implant 95 are provided below.
The delivery system 10 and the microcatheter 14 can have lengths sufficient to extend from outside the patient's body to a target location in the brain. For example, each of them can be at least 125 cm long, and more particularly may be between about 125 cm and about 175 cm long, with the delivery system 10 being longer than the microcatheter 14. Typically the microcatheter 14 is about 155 cm long. Commercially available microcatheters which may be suitable for use as delivery catheters include the REBAR™ Reinforced Micro Catheter, which is available from Medtronic, Inc. and the MARKSMAN™ Catheter, which is available from Medtronic, Inc.
When the delivery system 10 has been advanced to a target aneurysm 16, the implant 95 can be inserted within the aneurysm 16 and expanded to a fully deployed state, for example as illustrated in
According to some embodiments, the implant 95 is supported during delivery by a delivery connection assembly 12, from which the implant 95 can also be detached. According to some embodiments, for example as shown in
According to some embodiments, the pusher device 78 can include one or more arms 82 extending distally from a junction 80 of the pusher device 78 and through the port 54. One or more of the arms 82 can include a distal section 84 that can be positioned distal to at least a portion of the port 54 and/or within a cavity 96 of the implant 95. According to some embodiments, the arms 82 can extend longitudinally from the junction 80, and the distal sections 84 can extend radially outwardly from the arms 82. In at least one configuration, the distal sections 84 can define a maximum outer cross-sectional dimension 86 that is greater than the port inner cross-sectional dimension 58. Accordingly, passage of the distal sections 84 proximally through the port 54 is resisted until the distal sections 84 are transitioned to a different configuration.
According to some embodiments, the arms 82 are configured to flex, bend, pivot, or articulate with respect to the junction 80 in response to temperature changes. Such action can be achieved based on a programmed characteristic of the arms 82. When the arms 82 are at or above a transition temperature, the arms 82 can transition to a second configuration, such as an austenite state in a shape memory alloy, in which the arms 82 in a relaxed state can disengage from the implant 95, as will be more fully described herein.
The transition temperature at which the arms 82 begin to revert to the second configuration can be selected at the typical human body temperature (i.e., about 36.7° C. or 98° F.) or another temperature. The transition temperature can be selected above the typical human body temperature, and the transition temperature can be achieved in the arms 82 by an application of heat other than from the body. Exemplifying materials for use in the composition of the junction 80 and/or the arms 82 can include nickel-titanium (nitinol), copper-tin, copper-zinc, copper-zinc-tin, copper-zinc-xenon, copper-aluminum-nickel, copper-gold-zinc, gold-cadmium, gold-copper-zinc, iron-beryllium, iron-platinum, indium-thallium, iron-manganese, iron-nickel-titanium-cobalt, nickel-titanium-vanadium, silver-cadmium, and combinations thereof. Exemplifying materials can further include a shape memory polymer, such as polyurethane, polyethylene terephthalate (PET), or high density polyethylene (HDPE).
According to some embodiments, for example as shown in
At least a portion of the heating element 76 can provide an electrical circuit with adequate resistance to generate heat while electrical current is applied. The heating element 76 can include a number of coil windings about a portion of the pusher device 78, for example as illustrated in
According to some embodiments, the implant 95 can be positioned with the positioner 40 and the pusher device 78. Distally directed forces can be transmitted from the positioner 40 to the hub 50 of the implant 95. Additionally, proximally directed forces can be transmitted from the pusher device 78 to the hub 50 of the implant 95.
According to some embodiments, for example as shown in
According to some embodiments, for example as shown in
Although
According to some embodiments, for example as shown in
The proximal portion 102 can be disposed at the proximal end of the distal portion 104 and can further define a port 154. The port 154 can extend completely through the proximal portion 102. The port 154 can be large enough to receive the arms 82 of the pusher device 78. The port 154 can define a port inner cross-sectional dimension 158. The port inner cross-sectional dimension 158 can be a minimum or maximum inner cross-sectional dimension within a region of the proximal portion 102. For example, a region distal to the proximal portion 102 can include a cavity 196 that defines an inner cross-sectional dimension 198 that is greater than the port inner cross-sectional dimension 158.
According to some embodiments, for example as shown in
Although
The coil 182 can be positioned to extend about an outer periphery of a portion of the implant 95. For example, the coil 182 can wrap up around and engage the hub 50 of the implant 95. The coil 182 can extend proximal to the hub 50, along a length of the hub 50, and/or distal to the hub 50. For example, the coil 182 can extend to regions on one or both sides of the hub 50. A distalmost region of the coil 182 can engage a distal end of the hub 50. A proximalmost region of the coil 182 can engage a proximal end of the hub 50. Alternatively, a separate structure of the delivery connection assembly 122, e.g., a stop, can engage a proximal end of the hub 50.
The coil 182 can be affixed to the pusher section 180 of the positioner 140, such that movement of the pusher section 180 substantially transmit forces to the coil 182 and the implant 95. In at least one configuration, the coil 182 can be biased to form an inner cross-sectional dimension 188 that is smaller than the hub outer cross-sectional dimension 59. The bias of the coil 182 can refer to the tendency of the coil 182, in a relaxed configuration, to naturally move to a shape in which it forms the inner cross-sectional dimension 188. Despite this bias, the coil 182 may be prevented from completely achieving the shape of the relaxed configuration and instead engage the hub 50. While engaged on the hub 50, at least a portion of the coil 182 may have an inner cross-sectional dimension 188 that is equal to the hub outer cross-sectional dimension 59 of the hub 50. The bias can provide a force of engagement with the hub 50. Accordingly, movement of the hub 50 is limited or resisted until the coil 182 is transitioned to a different configuration.
According to some embodiments, the coil 182 is configured to flex, bend, unwind, and/or radially expand. Such action can be achieved based on a programmed characteristic of the coil 182. When the coil 182 is at or above a transition temperature, the coil 182 can transition to a second configuration, such as an austenite state in a shape memory alloy, in which the coil 182 in a relaxed state can disengage from the implant 95, as will be more fully described herein.
The transition temperature at which the coil 182 begins to revert to the second configuration can be selected at the typical human body temperature (i.e., about 36.7° C. or 98° F.) or another temperature. The transition temperature can be selected above the typical human body temperature, and the transition temperature can be achieved in the coil 182 by an application of heat other than from the patient's body. Exemplifying materials for use in the composition of the coil 182 can include nickel-titanium (nitinol), copper-tin, copper-zinc, copper-zinc-tin, copper-zinc-xenon, copper-aluminum-nickel, copper-gold-zinc, gold-cadmium, gold-copper-zinc, iron-beryllium, iron-platinum, indium-thallium, iron-manganese, iron-nickel-titanium-cobalt, nickel-titanium-vanadium, silver-cadmium, and combinations thereof. Exemplifying materials can further include a shape memory polymer, such as polyurethane, polyethylene terephthalate (PET), or high density polyethylene (HDPE).
According to some embodiments, for example as shown in
At least a portion of the heating element 176 can provide an electrical circuit with adequate resistance to generate heat while electrical current is applied. The heating element 176 can include a number of coil windings within a portion of the positioner 140, for example as illustrated in
While the coil 182 can be a single filament helical winding, as shown in
According to some embodiments, the implant 95 can be positioned with the delivery connection assembly 122. While the hub 50 is held within the coil 182, distally and/or proximally directed forces can be transmitted from the positioner 140 to the hub 50 of the implant 95. According to some embodiments, for example as shown in
According to some embodiments, for example as shown in
The foregoing description is provided to enable a person skilled in the art to practice the various configurations described herein. While the subject technology has been particularly described with reference to the various figures and configurations, it should be understood that these are for illustration purposes only and should not be taken as limiting the scope of the subject technology.
There may be many other ways to implement the subject technology. Various functions and elements described herein may be partitioned differently from those shown without departing from the scope of the subject technology. Various modifications to these configurations will be readily apparent to those skilled in the art, and generic principles defined herein may be applied to other configurations. Thus, many changes and modifications may be made to the subject technology, by one having ordinary skill in the art, without departing from the scope of the subject technology.
It is understood that the specific order or hierarchy of steps in the processes disclosed is an illustration of exemplifying approaches. Based upon design preferences, it is understood that the specific order or hierarchy of steps in the processes may be rearranged. Some of the steps may be performed simultaneously. The accompanying method claims present elements of the various steps in a sample order, and are not meant to be limited to the specific order or hierarchy presented.
A phrase such as “an aspect” does not imply that such aspect is essential to the subject technology or that such aspect applies to all configurations of the subject technology. A disclosure relating to an aspect may apply to all configurations, or one or more configurations. An aspect may provide one or more examples of the disclosure. A phrase such as “an aspect” may refer to one or more aspects and vice versa. A phrase such as “an embodiment” does not imply that such embodiment is essential to the subject technology or that such embodiment applies to all configurations of the subject technology. A disclosure relating to an embodiment may apply to all embodiments, or one or more embodiments. An embodiment may provide one or more examples of the disclosure. A phrase such “an embodiment” may refer to one or more embodiments and vice versa. A phrase such as “a configuration” does not imply that such configuration is essential to the subject technology or that such configuration applies to all configurations of the subject technology. A disclosure relating to a configuration may apply to all configurations, or one or more configurations. A configuration may provide one or more examples of the disclosure. A phrase such as “a configuration” may refer to one or more configurations and vice versa.
Furthermore, to the extent that the term “include,” “have,” or the like is used in the description or the claims, such term is intended to be inclusive in a manner similar to the term “comprise” as “comprise” is interpreted when employed as a transitional word in a claim.
A reference to an element in the singular is not intended to mean “one and only one” unless specifically stated, but rather “one or more.” The term “some” refers to one or more. All structural and functional equivalents to the elements of the various configurations described throughout this disclosure that are known or later come to be known to those of ordinary skill in the art are expressly incorporated herein by reference and intended to be encompassed by the subject technology. Moreover, nothing disclosed herein is intended to be dedicated to the public regardless of whether such disclosure is explicitly recited in the above description.
While certain aspects and embodiments of the subject technology have been described, these have been presented by way of example only, and are not intended to limit the scope of the subject technology. Indeed, the novel methods and systems described herein may be embodied in a variety of other forms without departing from the spirit thereof. The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the subject technology.
This application claims the benefit of priority of U.S. Provisional Patent Application No. 62/355,431, filed Jun. 28, 2016, which is hereby incorporated by reference in its entirety.
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