Claims
- 1. An implantable immunoisolatory vehicle for providing a biologically active product or function to an individual, the immunoisolatory vehicle comprising:
(a) a core comprising living cells dispersed in a biocompatible matrix formed of a hydrogen, said cells being capable of secreting a selected biologically active product or of providing a selected biological function to an individual; and (b) an external diffusional surface jacket surrounding said core formed of a biocompatible hydrogel material free of said cells projecting externally thereof, said jacket having a molecular weight cutoff below the molecular weight of substances essential for immunological rejection of the cells but permitting passage of substances between the individual and core through said jacket required to provide said biological product or function, said core and external jacket forming an interface substantially free of direct ionic bonding and of an intermediate linking layer.
RELATED APPLICATIONS
[0001] This is a continuation-in-part application of PCT application Ser. No. US 92/03327, filed Apr. 22, 1992, which is a continuation-in-part of application Ser. No. 07/692,403, filed Apr. 25, 1991.
Divisions (3)
|
Number |
Date |
Country |
Parent |
09148671 |
Sep 1998 |
US |
Child |
09563248 |
May 2000 |
US |
Parent |
08449837 |
May 1995 |
US |
Child |
09148671 |
Sep 1998 |
US |
Parent |
08179151 |
Jan 1994 |
US |
Child |
08449837 |
May 1995 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09563248 |
May 2000 |
US |
Child |
10007344 |
Oct 2001 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
PCT/US92/03327 |
Apr 1992 |
US |
Child |
08179151 |
Jan 1994 |
US |
Parent |
07692403 |
Apr 1991 |
US |
Child |
PCT/US92/03327 |
Apr 1992 |
US |