This application relates generally to spinal fusion implants and methods for fusing spinal vertebrae.
Currently there are nearly 750,000 spine lumbar and cervical fusion procedures performed each year in the United States. These procedures are commonly performed to correct problems with displaced, damaged, or degenerated intervertebral discs due to trauma, disease, or aging. One of the most common of these procedures is spinal fusion, which involves removing some or the all of the diseased or damaged disc, inserting one or more intervertebral spacers to restore the natural height of the disc space, and allowing a bony bridge to form through the disc space fusing the adjacent vertebrae together. Increasingly, so-called “total disc replacement” (TDR) procedures are being utilized as an alternative to spinal fusion. Total disc replacements represent a new wave of spinal technology and generally involve implantation of mechanical devices designed to replace the functions of the intervertebral disc and thus preserve motion that is lost through a spinal fusion. While several different approaches may be used to access the target spine (the most common being anterior, posterior, and posterolateral approaches), the anterior approach is often utilized, especially for TDR, because it allows for greater exposure and a more complete excision of the damaged disc than the other common approaches.
Sometimes after a spinal fusion or TDR procedure it becomes necessary to remove and/or replace the previously implanted implant. During such revision surgeries it may be preferable, though not necessary, to access the spinal target site from a different approach than that used in the original surgery. This presents a challenge, however, when performing a revision of an anterior procedure because the implants deposited during an anterior procedure are generally too large to be removed through the smaller access corridors achievable with the other traditional spinal approaches (e.g. posterior and postero-lateral). As an alternative, recent advances in both technology and methodology have made the lateral approach to the spine a viable surgical option. The lateral approach has proven to be a safe and effective means for performing spinal fusion and, unlike the posterior and postero-lateral approaches, the lateral approach allows for access to the disc space which is comparable to that gained through the anterior approach.
One difficulty with utilizing a lateral approach for revision surgery is the absence of the Anterior Longitudinal Ligament (ALL) which is removed during the original procedure for the anterior approach to the spine. With the ALL barrier removed, the lateral implant may be more susceptible to expulsion. A need therefore exists for interbody implants configured for insertion through a lateral approach to the spine and resistant to anterior expulsion.
Example embodiments of a fusion implant are described herein in accordance with aspects of the present invention. After insertion into a prepared disc space between adjacent vertebral bodies the fusion implant maintains a desired spatial arrangement between the adjacent vertebrae and facilitates the formation of a bony bridge between them. The embodiments shown herein are designed preferably for implantation into the disc space through a lateral approach. The implant may be comprised of any suitable bio-compatible material or a combination of multiple bio-compatible materials. Preferably, at least a portion of the spinal fusion implant may comprise a non-bone composition having radiolucent characteristics, including but not limited to polymer compositions (e.g. poly-ether-ether-ketone (PEEK) and/or poly-ether-ketone-ketone (PEKK)) or any combination of PEEK and PEKK. Other suitable materials used in the construction of implant may include but are not limited to ceramics and metals, such as titanium, by way of example only.
The fusion implants may be provided in any number of sizes by varying one or more of the implant height, width, and length. The dimensions of the implant may be altered according to proportions of the particular patient and/or further variation of the implant dimensions may be implemented to produce implants generally appropriate for implantation into either of the thoracic spine and the cervical spine.
Fusion may be facilitated or augmented by introducing or positioning various osteoinductive materials within the fusion implant and/or adjacent to the spinal fusion implant. Such osteoinductive materials may be introduced before, during, or after the insertion of the implant, and may include (but are not necessarily limited to) autologous bone harvested from the patient, bone allograft, bone xenograft, any number of non-bone implants (e.g. ceramic, metallic, polymer), bone morphogenic protein, and bio-resorbable compositions, including but not limited to any of a variety of poly (D,L-lactide-co-glycolide) based polymers.
The implant generally comprises an implant body and a keel structure. The implant body has a leading side and a trailing side at opposing ends along a longitudinal axis. Between the leading side and trailing side are an upper surface, a lower surface, an anterior side, and a posterior side. To maintain the disc space according to the natural curvature of the spine, the anterior side of the implant may possess a greater height dimension than the posterior side, such that upper surface and lower surface converge toward one another at posterior side. An implant with this configuration (i.e. a taller anterior side) is tailored to accommodate the natural lordotic curvature found in the lumbar and cervical spine. Alternatively, the implant may have a posterior side possessing a greater height dimension than an anterior side so as to accommodate the natural kyphotic curvature of the thoracic spine. In another alternative, the implant may have anterior and posterior sides of approximately the same height. Each of the upper surface and lower surface may be one of, or a combination of, generally planar, concave, and convex.
The body of the implant may be configured with at least one large fusion aperture and preferably includes between two and four large fusion apertures. The fusion apertures may be separated by a medial and/or longitudinal support, extending in a vertical fashion between upper surface and lower surface. The fusion apertures function primarily as an avenue for bony fusion between adjacent vertebrae. The spinal fusion implant may also have a plurality of visualization apertures extending through the anterior side and posterior side, which allow a user to assess the degree of bony fusion through visual observations (via X-ray, fluoroscopy, or other imaging technology), un-obscured by anterior side or posterior side.
The fusion implant may include anti-migration features designed to increase the traction between the spinal fusion implant and the contact surface of the adjacent vertebral bodies to guard against movement or slippage of the implant after implantation. Anti-migration features may include angled ridges provided along the upper surface and/or lower surface. Other anti-migration features may include one or more spike members disposed at various locations along the implant. The implant may include a total of six spike members disposed along each of the upper surface and the lower surface. The spike members may be manufactured from any of a variety of suitable materials, including but not limited to a metal, ceramic, and/or polymer material. Spike members may be provided having radiopaque characteristics. When the spike members are provided having radiodense characteristics and at least a portion of the implant is manufactured from a radiolucent material (such as, by way of example only, PEEK and/or PEKK), the spike members will be readily observable under X-ray or fluoroscopy such that a surgeon may track the progress of the implant during implantation and/or the placement of the implant after implantation. The spike members of the implant may include a male element and a female element which threadably engage each other through the implant body and clamp keel structures to the implant body. Alternatively, the spike members may each comprise a unitary element extending through the upper surface and lower surface. The spike elements may include a threaded end that engages the holes through the implant body and/or keel structures to hold keel structures to the body. The spike members may comprise a shorter element which only extends through a single surface. Additionally, while referred to as spike elements and shown with pointed tips, the spike elements may include other shapes configured to engage the vertebral endplates.
Additional members in the form of keel structures augment the anti-migration features of the implant and further stabilize the position of the implant within the disc space. Keel structures may extend above the upper surface and/or below the lower surface along at least a portion of the longitudinal axis of implant between leading side and trailing side. Keel structures may be canted or generally perpendicular to the surface from which they extend. The keel structures may extend along the approximate centerline of the implant. Alternatively, the keels may be situated nearer to one of the anterior side and posterior side. During implantation the keel structures are inserted into keel channels formed in the adjacent vertebrae. Apertures may be provided along the length of the keel, or a portion thereof, to permit bony ingrowth through the keel structures.
The keel structures can be made from the same material as the implant body or they can be made from a different material, or combination of materials. By way of example, the keel structures may be comprised of a metal (e.g. titanium) and the implant body may be comprised of a polymer (e.g. PEEK or PEKK). Alternatively, the keel may be comprised of a polymer (e.g. PEEK or PEKK) and the implant may also be comprised of a polymer (e.g. PEEK or PEKK). Similarly, the implant body and keel structures may be formed as a single part, or as a combination of parts.
The leading side of the implant may be tapered to facilitate insertion of the implant into the disc space between adjacent vertebrae. The trailing side of the implant may possess mating structures configured for engagement with an insertion instrument. The mating structures may include a threaded receiving aperture and a pair of grooved purchase regions extending generally horizontally from either side of the receiving aperture. The receiving aperture may extend inwardly from the trailing side in a generally perpendicular fashion relative to the trailing side and may be dimensioned to threadably receive a threaded connector on the insertion instrument. The grooved purchase regions are dimensioned to receive corresponding distal head ridges on the insertion instrument, which collectively provide an enhanced engagement between the implant and insertion instrument.
According to one example, a trial sizer and keel cutter instrument may be provided. The trial sizer may be inserted into the interbody disc space to determine the appropriate size implant required to achieved the desired disc height. The keel cutter may be guided along grooves in the trial sizer and advanced into the interbody disc space to form channels in the vertebral bodies for receiving the keel structures. The inserter may releasably attaches at its distal end to an implant for advancement and depositing of the implant within the interbody disc space after the channels have been formed. A threadable attachment means is shown, but other means of releasable attachment are contemplated.
Many advantages of the present invention will be apparent to those skilled in the art with a reading of this specification in conjunction with the attached drawings, wherein like reference numerals are applied to like members and wherein:
Illustrative embodiments of the invention are described below. In the interest of clarity, not all features of an actual implementation are described in this specification. It will of course be appreciated that in the development of any such actual embodiment, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with implant-related and business-related constraints, which will vary from one implementation to another. Moreover, it will be appreciated that such a development effort might be complex and time-consuming, but would nevertheless be a routine undertaking for those of ordinary skill in the art having the benefit of this disclosure. The implants disclosed herein boasts a variety of inventive features and components that warrant patent protection, both individually and in combination.
Example embodiments of a fusion implant are described herein in accordance with aspects of the present invention. After insertion into a prepared disc space between adjacent vertebral bodies the fusion implant maintains a desired spatial arrangement between the adjacent vertebrae and facilitates the formation of a bony bridge between them. The embodiments shown herein are designed for implantation into the disc space through a lateral (e.g. trans-psoas) access corridor. The implant may be comprised of any suitable bio-compatible material or a combination of multiple bio-compatible materials. Preferably, at least a portion of the spinal fusion implant may comprise a non-bone composition having radiolucent characteristics, including but not limited to polymer compositions (e.g. poly-ether-ether-ketone (PEEK) and/or poly-ether-ketone-ketone (PEKK)) or any combination of PEEK and PEKK. Other suitable materials used in the construction of the implants may include but are not limited to ceramics and metals, such as titanium, by way of example only.
The fusion implants may be provided in any number of sizes by varying one or more of the implant height, width, and length. By way of example only, the implant may be provided with a length dimension ranging from 30 mm to 60 mm. By way of further example, the implant may be provided with a width dimension ranging from 15 mm to 22 mm. By way of still further example, the implant may be provided with a height dimension ranging from 5 mm to 22 mm. The size ranges described are those generally appropriate for implantation into the lumbar spine. The dimensions of the implant may be altered according to proportions of the particular patient and/or further variation of the implant dimensions may be implemented to produce implants generally appropriate for implantation into either of the thoracic spine and the cervical spine.
Fusion may be facilitated or augmented by introducing or positioning various osteoinductive materials within the fusion implant and/or adjacent to the spinal fusion implant. Such osteoinductive materials may be introduced before, during, or after the insertion of the implant, and may include (but are not necessarily limited to) autologous bone harvested from the patient, bone allograft, bone xenograft, any number of non-bone implants (e.g. ceramic, metallic, polymer), bone morphogenic protein, and bio-resorbable compositions, including but not limited to any of a variety of poly (D,L-lactide-co-glycolide) based polymers.
As illustrated in
As best illustrated in
Other anti-migration features may include one or more spike members 34 disposed at various locations along the implant 10, as best illustrated in
Additional members in the form of keel structures 36 augment the anti-migration features of implant 10 and further stabilize the position of the implant 10 within the disc space. Keel structures 36 may extend above the upper surface 18 and/or below the lower surface 20 along at least a portion of the longitudinal axis 17 of implant 10 between leading side 14 and trailing side 16. By way of example only, keel structures may rise approximately 2.5 mm from the upper and/or lower surfaces 18, 20. As best pictured in
The keel structures 36 can be made from the same material as implant body 12 or they can be made from a different material, or combination of materials. In this first embodiment, by way of example, the keel structures 36 are comprised of a metal (e.g. titanium) and the implant body is comprised of a polymer (e.g. PEEK or PEKK). It will be appreciated, however, that both the implant body 12 and keel structures 36 could be made from a polymer material or, both could be made of a metal material. Similarly, the implant body 12 and keel structures 36 may be formed as a single part, or as a combination of parts. By way of example, as illustrated in
As illustrated in
The body 112 of the implant 110 may be configured with at least one large fusion aperture 126. As shown in
As best illustrated in
As illustrated in
The keel structures 136 can be made from the same material as implant body 112 or they can be made from a different material, or combination of materials. In this second embodiment, by way of example, the keel structures 136 are comprised of a metal (e.g. titanium) and the implant body is comprised of a polymer (e.g. PEEK or PEKK). It will be appreciated, however, that both the implant body 112 and keel structures 136 could be made from a polymer material, or both could be made of a metal material. Similarly, the implant body 112 and keel structures 136 may be formed as a single part, or as a combination of parts. By way of example, as best illustrated in
As illustrated in
As illustrated in
As shown in
To protect against movement or slippage of the implant 210 after implantation, the fusion implant 210 may include anti-migration features designed to increase the traction between the spinal fusion implant 210 and the adjacent vertebral bodies. These anti-migration features may include angled ridges 232 provided along the upper surface 218 and/or lower surface 220. The angled ridges 232 may be oriented such that they do not resist movement in the direction of insertion (i.e. towards the leading end) but do resist movement in the opposing direction. This allows the implant 210 to be inserted without the need for excessive force that may cause damage to the vertebrae and/or the implant, while still preventing the implant from moving back along the path of insertion where natural barriers (e.g. the annulus fibrosis, or surrounding ligaments) were removed in order to access to the disc space for implant insertion.
Additional anti-migration features in the form of keel structures 236 further stabilize the position of the implant 210 within the disc space. Keel structures 236 may extend above the upper surface 218 and/or below the lower surface 220 along at least a portion of the longitudinal axis 217 of implant 210 between leading side 214 and trailing side 216. By way of example only, keel structures 236 may rise approximately 2.5 mm from the upper and/or lower surfaces 218, 220. As best pictured in
As illustrated in
The keel structures 236 can be made from the same material as implant body 212 or they can be made from a different material, or combination of materials. In this third embodiment, by way of example, the keel structures 236 are comprised of a metal (e.g. titanium) and the implant body is comprised of a polymer (e.g. PEEK or PEKK). It will be appreciated that both the implant body 212 and keel structures 236 could be made from a polymer material, or both could be made of a metal material. Similarly, the implant body 212 and keel structures 236 may be formed as a single part, or as a combination of parts. By way of example only, as shown in
As illustrated in
As shown in
To protect against movement or slippage of the implant 310 after implantation, the fusion implant 310 may include anti-migration features designed to increase the traction between the spinal fusion implant 310 and the adjacent vertebral bodies. These anti-migration features, best viewed in
Additional members in the form of keel structures 336 augment the anti-migration features of implant 310 and further stabilize the position of the implant 310 within the disc space. Keel structures 336 may extend above the upper surface 318 and/or below the lower surface 320 along at least a portion of the longitudinal axis 317 of implant 310 between leading side 314 and trailing side 316. By way of example only, keel structures 336 may rise approximately 2.5 mm from the upper and/or lower surfaces 318, 320. As best pictured in
The keel structures 336 can be made from the same material as implant body 312 or they can be made from a different material, or combination of materials. In this fourth embodiment, by way of example, the keel structures 336 are comprised of a metal (e.g. titanium) and the implant body is comprised of a polymer (e.g. PEEK or PEKK). It will be appreciated that both the implant body 312 and keel structures 336 could be made from a polymer material, or both could be made of a metal material. Similarly, the implant body 312 and keel structures 336 may be formed as a single part, or as a combination of parts. By way of example only, as shown in
As illustrated in
As illustrated in
As illustrated in
As illustrated in
For trial sizing, the trial sizer 411 is releasably attached to the inserter 470. The trial sizer 411 is progressed into the intervertebral space by sliding the inserter shaft 405 distally in relation to the inserter holder 430 until the trial sizer 411 is received into the intervertebral space. To remove the trial sizer 411, the inserter shaft 405 slides proximally in relation to the inserter holder 430 until the trial sizer 411 is free of the surgical corridor.
As illustrated in
As best illustrated in
The elongate tubular element 502 is dimensioned to receive a spring 524 and the proximal end of the inserter shaft 504 into the inner bore (not shown) of the elongate tubular element 502. The inserter shaft 504 is dimensioned such that the threaded connector 522 at the distal end of the inserter shaft 504 protrudes from the inner bore, past the distal head ridges 508 to allow engagement with, by way of example only, the receiving aperture 148 of the spinal fusion implant 110 or trial sizer. It should be appreciated by one skilled in the art that such a construction allows the inserter shaft 504 to be able to rotate freely within the elongate tubular element 502 while stabilized by a spring 524 to reduce any slidable play in the insertion instrument 500. The distal head ridges 508 are dimensioned to fit slidably into the purchase regions 150 with low friction to allow accurate engagement of the threaded connector 522 to the receiving aperture 148 of the spinal fusion implant 110 or trial sizer. In the presented embodiment, the outer dimension of the threaded connector 522 is smaller than the largest outer dimension of the distal head 506 and elongate tubular element 502. Alternatively, other methods of creating a gripping surface are contemplated including but not limited to knurling or facets.
As illustrated in
A clinician can utilize the secured implant in either an open or minimally invasive spinal fusion procedure. In either type of procedure, a surgical corridor is created in a patient that reaches the targeted spinal level. After the creation of that corridor, the intervertebral space may be prepared via any number of well known preparation tools, including but not limited to kerrisons, rongeurs, pituitaries, and rasps. Alternatively, if the intervertebral space already contains an implant to be replaced, that implant will be removed. After preparation, various trial sizers may be temporarily placed in the intervertebral space to determine the appropriate size of the final implant. With the appropriate trial sizer in place, keel channels 630 may be cut into the endplates or beyond the endplates into the cancellous bone of the adjacent vertebrae as needed to accommodate the desired keel structures 36. First, the trial sizer is inserted into the disc space, as in
While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and are herein described in detail. It should be understood, however, that the description herein of specific embodiments is not intended to limit the invention to the particular forms disclosed, but on the contrary, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined herein.
This application is a continuation of U.S. patent application Ser. No. 13/337,967 filed Dec. 27, 2011, now U.S. Pat. No. 9,168,152, which is a continuation of U.S. patent application Ser. No. 12/380,693 filed Mar. 2, 2009, now U.S. Pat. No. 8,083,796, which claims the benefit of priority under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application No. 61/067,700 filed Feb. 29, 2008, and U.S. Provisional Patent Application No. 61/105,796 filed Oct. 15, 2008, the entire contents of which are each incorporated by reference as if set forth herein in their entireties.
Number | Name | Date | Kind |
---|---|---|---|
3486505 | Morrison | Dec 1969 | A |
3518993 | Blake | Jul 1970 | A |
3604487 | Gilbert | Sep 1971 | A |
3745995 | Kraus | Jul 1973 | A |
3848601 | Ma et al. | Nov 1974 | A |
3867728 | Stubstad et al. | Feb 1975 | A |
4026304 | Levy | May 1977 | A |
4026305 | Brownlee et al. | May 1977 | A |
4349921 | Kuntz | Sep 1982 | A |
4454374 | Pollack | Jun 1984 | A |
4501269 | Bagby | Feb 1985 | A |
4545374 | Jacobson | Oct 1985 | A |
4646738 | Trott | Mar 1987 | A |
4657550 | Daher | Apr 1987 | A |
4697586 | Gazale | Oct 1987 | A |
4743256 | Brantigan | May 1988 | A |
4781591 | Allen | Nov 1988 | A |
4834757 | Brantigan | May 1989 | A |
4877020 | Vich | Oct 1989 | A |
4878915 | Brantigan | Nov 1989 | A |
4932975 | Main et al. | Jun 1990 | A |
4950296 | McIntyre | Aug 1990 | A |
4961740 | Ray et al. | Oct 1990 | A |
4962766 | Herzon | Oct 1990 | A |
5015247 | Michelson | May 1991 | A |
5026373 | Ray et al. | Jun 1991 | A |
5047055 | Bao et al. | Sep 1991 | A |
5055104 | Ray | Oct 1991 | A |
5062845 | Kuslich et al. | Nov 1991 | A |
5071437 | Steffee | Dec 1991 | A |
5092572 | Litwak et al. | Mar 1992 | A |
5133717 | Chopin | Jul 1992 | A |
5133755 | Brekke | Jul 1992 | A |
5171278 | Pisharodi | Dec 1992 | A |
5192327 | Brantigan | Mar 1993 | A |
5217497 | Mehdian | Jun 1993 | A |
5263953 | Bagby | Nov 1993 | A |
5269785 | Bonutti | Dec 1993 | A |
5284153 | Raymond et al. | Feb 1994 | A |
5290494 | Coombes et al. | Mar 1994 | A |
5300076 | Leriche | Apr 1994 | A |
5304210 | Crook | Apr 1994 | A |
5306307 | Senter et al. | Apr 1994 | A |
5306309 | Wagner et al. | Apr 1994 | A |
5322505 | Krause et al. | Jun 1994 | A |
5334205 | Cain | Aug 1994 | A |
5336223 | Rogers | Aug 1994 | A |
5364400 | Rego, Jr. et al. | Nov 1994 | A |
5395372 | Holt et al. | Mar 1995 | A |
5397363 | Gelbard | Mar 1995 | A |
5397364 | Kozak | Mar 1995 | A |
5401269 | Keller | Mar 1995 | A |
5405391 | Henderson et al. | Apr 1995 | A |
5413602 | Metz-Stavenhagen | May 1995 | A |
5425772 | Brantigan | Jun 1995 | A |
5431658 | Moskovich | Jul 1995 | A |
5443514 | Steffee | Aug 1995 | A |
5443515 | Cohen et al. | Aug 1995 | A |
5445639 | Kuslich et al. | Aug 1995 | A |
5454811 | Huebner | Oct 1995 | A |
5458638 | Kuslich et al. | Oct 1995 | A |
5484403 | Yoakum et al. | Jan 1996 | A |
5484437 | Michelson | Jan 1996 | A |
5489307 | Kuslich et al. | Feb 1996 | A |
5489308 | Kuslich et al. | Feb 1996 | A |
5514180 | Heggeness et al. | May 1996 | A |
5522879 | Scopelianos | Jun 1996 | A |
5522899 | Michelson | Jun 1996 | A |
5524624 | Tepper et al. | Jun 1996 | A |
5527312 | Ray | Jun 1996 | A |
5534030 | Navarro et al. | Jul 1996 | A |
5540688 | Navas | Jul 1996 | A |
5545222 | Bonutti | Aug 1996 | A |
5545688 | Huang | Aug 1996 | A |
5562736 | Ray et al. | Oct 1996 | A |
5565005 | Erickson et al. | Oct 1996 | A |
5571190 | Ulrich | Nov 1996 | A |
5571192 | Schonhoffer | Nov 1996 | A |
5593409 | Michelson | Jan 1997 | A |
5607424 | Tropiano | Mar 1997 | A |
5609636 | Kohrs | Mar 1997 | A |
5611800 | Davis et al. | Mar 1997 | A |
5611810 | Arnold et al. | Mar 1997 | A |
5632747 | Scarborough et al. | May 1997 | A |
5645596 | Kim et al. | Jul 1997 | A |
5645598 | Brosnahan et al. | Jul 1997 | A |
5653761 | Pisharodi | Aug 1997 | A |
5653762 | Pisharodi | Aug 1997 | A |
5658336 | Pisdharodi | Aug 1997 | A |
5658337 | Kohrs | Aug 1997 | A |
5662710 | Bonutti | Sep 1997 | A |
5665122 | Kambin | Sep 1997 | A |
5669909 | Zdeblick et al. | Sep 1997 | A |
5676703 | Gelbard | Oct 1997 | A |
5683394 | Rinner | Nov 1997 | A |
5683400 | McGuire | Nov 1997 | A |
5683464 | Wagner et al. | Nov 1997 | A |
5683465 | Shinn | Nov 1997 | A |
5690629 | Asher et al. | Nov 1997 | A |
5700264 | Zucherman et al. | Dec 1997 | A |
5700291 | Kuslich et al. | Dec 1997 | A |
5700292 | Marguiles | Dec 1997 | A |
5702449 | McKay | Dec 1997 | A |
5702451 | Biedermann et al. | Dec 1997 | A |
5702453 | Rabbe et al. | Dec 1997 | A |
5702454 | Baumgartner | Dec 1997 | A |
5702455 | Saggar | Dec 1997 | A |
5703451 | Yamamichi et al. | Dec 1997 | A |
5707373 | Sevrain et al. | Jan 1998 | A |
5711957 | Patat et al. | Jan 1998 | A |
5716415 | Steffee | Feb 1998 | A |
5720748 | Kuslich et al. | Feb 1998 | A |
5720751 | Jackson | Feb 1998 | A |
5722977 | Wilhelmy | Mar 1998 | A |
5728159 | Stroever et al. | Mar 1998 | A |
5741253 | Michelson | Apr 1998 | A |
5741261 | Moskovitz et al. | Apr 1998 | A |
5755797 | Baumgartner | May 1998 | A |
5766252 | Henry et al. | Jun 1998 | A |
5772661 | Michelson | Jun 1998 | A |
5775331 | Raymond et al. | Jul 1998 | A |
5775797 | Henstra | Jul 1998 | A |
5779642 | Nightengale | Jul 1998 | A |
5782830 | Farris | Jul 1998 | A |
5782832 | Larsen | Jul 1998 | A |
5782919 | Zdeblick et al. | Jul 1998 | A |
5785710 | Michelson | Jul 1998 | A |
5797909 | Michelson | Aug 1998 | A |
5800549 | Bao et al. | Sep 1998 | A |
5800550 | Sertich | Sep 1998 | A |
5814084 | Grivas et al. | Sep 1998 | A |
5814550 | Wolcott | Sep 1998 | A |
5851084 | Nishikawa | Dec 1998 | A |
5851208 | Trott | Dec 1998 | A |
5860973 | Michelson | Jan 1999 | A |
5865845 | Thalgott | Feb 1999 | A |
5865848 | Baker | Feb 1999 | A |
5885299 | Winslow et al. | Mar 1999 | A |
5888219 | Bonutti | Mar 1999 | A |
5888224 | Beckers et al. | Mar 1999 | A |
5893889 | Harrington | Apr 1999 | A |
5893890 | Pisharodi | Apr 1999 | A |
5904719 | Errico et al. | May 1999 | A |
5910315 | Stevenson et al. | Jun 1999 | A |
5942698 | Stevens | Aug 1999 | A |
5954769 | Rosenlicht | Sep 1999 | A |
5968098 | Winslow | Oct 1999 | A |
5989291 | Ralph | Nov 1999 | A |
5993474 | Ouchi | Nov 1999 | A |
6003426 | Kobayashi et al. | Dec 1999 | A |
6004326 | Castro et al. | Dec 1999 | A |
6008433 | Stone | Dec 1999 | A |
6015436 | Schunhuffer | Jan 2000 | A |
6033405 | Winslow et al. | Mar 2000 | A |
6033438 | Bianchi et al. | Mar 2000 | A |
6039761 | Li et al. | Mar 2000 | A |
6042582 | Ray | Mar 2000 | A |
6045580 | Scarborough et al. | Apr 2000 | A |
6045582 | Prybyla | Apr 2000 | A |
6048342 | Zucherman et al. | Apr 2000 | A |
6059829 | Schlapfer et al. | May 2000 | A |
6063088 | Winslow | May 2000 | A |
6063121 | Xavier | May 2000 | A |
6080155 | Michelson | Jun 2000 | A |
6083225 | Winslow et al. | Jul 2000 | A |
6090143 | Meriwether | Jul 2000 | A |
6096080 | Nicholson et al. | Aug 2000 | A |
6102948 | Brosnahan, III | Aug 2000 | A |
6120503 | Michelson | Sep 2000 | A |
6120506 | Kohrs et al. | Sep 2000 | A |
6132472 | Bonutti | Oct 2000 | A |
6143033 | Paul et al. | Nov 2000 | A |
6159211 | Boriani | Dec 2000 | A |
6159215 | Urbahns et al. | Dec 2000 | A |
6193756 | Studer et al. | Feb 2001 | B1 |
6200347 | Anderson | Mar 2001 | B1 |
6224607 | Michelson | May 2001 | B1 |
6224631 | Kohrs | May 2001 | B1 |
6241769 | Nicholson et al. | Jun 2001 | B1 |
6241770 | Michelson | Jun 2001 | B1 |
6241771 | Gresser et al. | Jun 2001 | B1 |
6245108 | Biscup | Jun 2001 | B1 |
6251140 | Marino et al. | Jun 2001 | B1 |
6258125 | Paul et al. | Jul 2001 | B1 |
6277149 | Boyle et al. | Aug 2001 | B1 |
6304487 | Pawletko et al. | Oct 2001 | B1 |
6309421 | Pisharodi | Oct 2001 | B1 |
6319257 | Carignan et al. | Nov 2001 | B1 |
6368350 | Erickson | Apr 2002 | B1 |
6371989 | Chauvin et al. | Apr 2002 | B1 |
6383221 | Scarborough et al. | May 2002 | B1 |
6409766 | Brett | Jun 2002 | B1 |
6413278 | Marchosky | Jul 2002 | B1 |
6425772 | Bernier et al. | Jul 2002 | B1 |
6426772 | Yoneyama et al. | Jul 2002 | B1 |
6432140 | Lin | Aug 2002 | B1 |
6440142 | Ralph et al. | Aug 2002 | B1 |
6442814 | Landry et al. | Sep 2002 | B1 |
6447546 | Bramlet | Sep 2002 | B1 |
6447547 | Michelson | Sep 2002 | B1 |
6454806 | Cohen et al. | Sep 2002 | B1 |
6468311 | Boyd et al. | Oct 2002 | B2 |
6491724 | Ferree | Dec 2002 | B1 |
6527773 | Lin et al. | Mar 2003 | B1 |
D472634 | Anderson | Apr 2003 | S |
D473650 | Anderson | Apr 2003 | S |
6547823 | Scarborough et al. | Apr 2003 | B2 |
6558424 | Thalgott | May 2003 | B2 |
6562072 | Fuss et al. | May 2003 | B1 |
6595998 | Johnson et al. | Jul 2003 | B2 |
6599294 | Fuss et al. | Jul 2003 | B2 |
6626905 | Schmiel et al. | Sep 2003 | B1 |
6635086 | Lin | Oct 2003 | B2 |
6648895 | Burkus et al. | Nov 2003 | B2 |
6666888 | Jackson | Dec 2003 | B1 |
6666889 | Commarmond | Dec 2003 | B1 |
6672019 | Wenz | Jan 2004 | B1 |
6676703 | Biscup | Jan 2004 | B2 |
6706067 | Shimp et al. | Mar 2004 | B2 |
6723097 | Fraser et al. | Apr 2004 | B2 |
6743255 | Ferree | Jun 2004 | B2 |
6746484 | Liu et al. | Jun 2004 | B1 |
6755841 | Fraser et al. | Jun 2004 | B2 |
6761739 | Shepard | Jul 2004 | B2 |
6767367 | Michelson | Jul 2004 | B1 |
6802863 | Lawson | Oct 2004 | B2 |
6824564 | Crozet | Nov 2004 | B2 |
6830570 | Frey et al. | Dec 2004 | B1 |
6835208 | Marchosky | Dec 2004 | B2 |
6843804 | Bryan | Jan 2005 | B2 |
D503801 | Jackson | Apr 2005 | S |
6923814 | Hildebrand et al. | Aug 2005 | B1 |
6942697 | Lange | Sep 2005 | B2 |
6942698 | Jackson | Sep 2005 | B1 |
6964687 | Bernard et al. | Nov 2005 | B1 |
6974480 | Messerli et al. | Dec 2005 | B2 |
6979353 | Bresina | Dec 2005 | B2 |
6984245 | McGahan et al. | Jan 2006 | B2 |
6986788 | Paul et al. | Jan 2006 | B2 |
6989031 | Michelson | Jan 2006 | B2 |
7018412 | Ferreira | Mar 2006 | B2 |
7018416 | Hanson et al. | Mar 2006 | B2 |
7056344 | Huppert | Jun 2006 | B2 |
7060073 | DeRidder | Jun 2006 | B2 |
7060097 | Hawkins | Jun 2006 | B2 |
7060099 | Carli | Jun 2006 | B2 |
7083651 | Diaz | Aug 2006 | B2 |
D530423 | Miles et al. | Oct 2006 | S |
7115144 | Diaz | Oct 2006 | B2 |
7125425 | Foley et al. | Oct 2006 | B2 |
7192447 | Rhoda | Mar 2007 | B2 |
7201776 | Ferree | Apr 2007 | B2 |
7244258 | Burkus et al. | Jul 2007 | B2 |
7303583 | Schaer et al. | Dec 2007 | B1 |
7326251 | McCombe et al. | Feb 2008 | B2 |
7361193 | Frey | Apr 2008 | B2 |
7442211 | De Villiers | Oct 2008 | B2 |
7815682 | Curran | Oct 2010 | B1 |
7832409 | Richelsoph | Nov 2010 | B2 |
7867277 | Tohmeh | Jan 2011 | B1 |
7918891 | Curran | Apr 2011 | B1 |
7951203 | McCombe et al. | May 2011 | B2 |
8021427 | Spoonamore | Sep 2011 | B2 |
8021430 | Michelson | Sep 2011 | B2 |
8187334 | Curran et al. | May 2012 | B2 |
8246686 | Curran et al. | Aug 2012 | B1 |
8251997 | Michelson | Aug 2012 | B2 |
8361156 | Curran et al. | Jan 2013 | B2 |
8425612 | Perez-Cruet et al. | Apr 2013 | B2 |
8506630 | Wardlaw | Aug 2013 | B2 |
8506636 | Dye | Aug 2013 | B2 |
8574301 | Curran et al. | Nov 2013 | B2 |
8579909 | Burkus et al. | Nov 2013 | B2 |
8591589 | McCombe et al. | Nov 2013 | B2 |
8608804 | Curran et al. | Dec 2013 | B2 |
8900307 | Hawkins | Dec 2014 | B2 |
20010016741 | Burkus et al. | Aug 2001 | A1 |
20010016777 | Biscup | Aug 2001 | A1 |
20020019637 | Frey et al. | Feb 2002 | A1 |
20020035400 | Bryan | Mar 2002 | A1 |
20020058950 | Winterbottom et al. | May 2002 | A1 |
20020068936 | Burkus et al. | Jun 2002 | A1 |
20020077702 | Castro | Jun 2002 | A1 |
20020111687 | Tatar | Aug 2002 | A1 |
20020116008 | Lin et al. | Aug 2002 | A1 |
20020165550 | Frey et al. | Nov 2002 | A1 |
20020165613 | Lin | Nov 2002 | A1 |
20030023306 | Liu et al. | Jan 2003 | A1 |
20030028249 | Baccelli et al. | Feb 2003 | A1 |
20030040802 | Errico | Feb 2003 | A1 |
20030074076 | Ferree | Apr 2003 | A1 |
20030100950 | Moret | May 2003 | A1 |
20030105527 | Bresina | Jun 2003 | A1 |
20030105528 | Shimp et al. | Jun 2003 | A1 |
20030109928 | Pasquet et al. | Jun 2003 | A1 |
20030139812 | Garcia et al. | Jul 2003 | A1 |
20030139813 | Messerli | Jul 2003 | A1 |
20030149438 | Nichols et al. | Aug 2003 | A1 |
20030153975 | Byrd | Aug 2003 | A1 |
20030167091 | Scharf | Sep 2003 | A1 |
20030208273 | Eisermann | Nov 2003 | A1 |
20030220691 | Songer | Nov 2003 | A1 |
20030233146 | Grinberg | Dec 2003 | A1 |
20040002759 | Ferree | Jan 2004 | A1 |
20040024408 | Burkus et al. | Feb 2004 | A1 |
20040024460 | Ferree | Feb 2004 | A1 |
20040024461 | Ferree | Feb 2004 | A1 |
20040030398 | Ferree | Feb 2004 | A1 |
20040093087 | Ferree | May 2004 | A1 |
20040117020 | Frey | Jun 2004 | A1 |
20040117022 | Marnay | Jun 2004 | A1 |
20040127990 | Bartish | Jul 2004 | A1 |
20040127991 | Ferree | Jul 2004 | A1 |
20040127994 | Kast | Jul 2004 | A1 |
20040143332 | Krueger | Jul 2004 | A1 |
20040148028 | Ferree | Jul 2004 | A1 |
20040153155 | Chung et al. | Aug 2004 | A1 |
20040158254 | Eisermann | Aug 2004 | A1 |
20040158328 | Eisermann | Aug 2004 | A1 |
20040176775 | Burkus et al. | Sep 2004 | A1 |
20040186572 | Lange | Sep 2004 | A1 |
20040193273 | Huang | Sep 2004 | A1 |
20040199251 | McCombe et al. | Oct 2004 | A1 |
20040215198 | Marnay | Oct 2004 | A1 |
20040220567 | Eisermann | Nov 2004 | A1 |
20040220668 | Eisermann | Nov 2004 | A1 |
20040220670 | Eisermann | Nov 2004 | A1 |
20040225365 | Eisermann | Nov 2004 | A1 |
20040225366 | Eisermann | Nov 2004 | A1 |
20040230307 | Eisermann | Nov 2004 | A1 |
20040243240 | Beaurain | Dec 2004 | A1 |
20040267364 | Carli | Dec 2004 | A1 |
20050021146 | de Villiers | Jan 2005 | A1 |
20050038516 | Spoonamore | Feb 2005 | A1 |
20050043802 | Eisermann | Feb 2005 | A1 |
20050043803 | Schultz | Feb 2005 | A1 |
20050059971 | Michelson | Mar 2005 | A1 |
20050065611 | Huppert | Mar 2005 | A1 |
20050125062 | Biedermann | Jun 2005 | A1 |
20050149192 | Zucherman | Jul 2005 | A1 |
20050149193 | Zucherman | Jul 2005 | A1 |
20050187625 | Wolek et al. | Aug 2005 | A1 |
20050197702 | Coppes et al. | Sep 2005 | A1 |
20050203538 | Lo et al. | Sep 2005 | A1 |
20060041314 | Millard | Feb 2006 | A1 |
20060058876 | McKinley | Mar 2006 | A1 |
20060069440 | Zucherman | Mar 2006 | A1 |
20060074488 | Abdou | Apr 2006 | A1 |
20060089714 | Liu | Apr 2006 | A1 |
20060095132 | Kirschman | May 2006 | A1 |
20060111783 | Aflatoon | May 2006 | A1 |
20060116768 | Krueger | Jun 2006 | A1 |
20060142864 | Cauthen | Jun 2006 | A1 |
20060155377 | Beaurain | Jul 2006 | A1 |
20060167549 | Mathys | Jul 2006 | A1 |
20060190084 | Doubler | Aug 2006 | A1 |
20060235526 | Lemaire | Oct 2006 | A1 |
20060259144 | Trieu | Nov 2006 | A1 |
20070043442 | Abernathie | Feb 2007 | A1 |
20070179612 | Johnson et al. | Aug 2007 | A1 |
20070191945 | Yu et al. | Aug 2007 | A1 |
20070233262 | Arnin | Oct 2007 | A1 |
20070260320 | Peterman | Nov 2007 | A1 |
20070270951 | Davis | Nov 2007 | A1 |
20070276495 | Aaron | Nov 2007 | A1 |
20070276499 | Paul et al. | Nov 2007 | A1 |
20070288007 | Burkus et al. | Dec 2007 | A1 |
20080009946 | Douget | Jan 2008 | A1 |
20080015701 | Garcia et al. | Jan 2008 | A1 |
20080027550 | Link | Jan 2008 | A1 |
20080058838 | Steinberg | Mar 2008 | A1 |
20080058940 | Wu | Mar 2008 | A1 |
20080065219 | Dye | Mar 2008 | A1 |
20080082173 | Delurio | Apr 2008 | A1 |
20080119937 | McCombe et al. | May 2008 | A1 |
20080183296 | Ferree | Jul 2008 | A1 |
20090036927 | Vestgaarden | Feb 2009 | A1 |
20090069895 | Gittings | Mar 2009 | A1 |
20090076610 | Afzal | Mar 2009 | A1 |
20090143859 | McClellan | Jun 2009 | A1 |
20090198339 | Kleiner | Aug 2009 | A1 |
20090204219 | Beaurain | Aug 2009 | A1 |
20090222099 | Liu et al. | Sep 2009 | A1 |
20100036497 | Lechmann | Feb 2010 | A1 |
20100106250 | Abdou | Apr 2010 | A1 |
20100152853 | Kirschman | Jun 2010 | A1 |
20100211176 | Greenhalgh | Aug 2010 | A1 |
20100249936 | Bertagnoli | Sep 2010 | A1 |
20100262246 | Attia | Oct 2010 | A1 |
20110054617 | Sekhon | Mar 2011 | A1 |
20110082552 | Wistrom | Apr 2011 | A1 |
20110112642 | Tohmeh | May 2011 | A1 |
20110196496 | McCombe et al. | Aug 2011 | A1 |
20120078374 | Villiers et al. | Mar 2012 | A1 |
20120158141 | Johnson et al. | Jun 2012 | A1 |
20120179261 | Soo | Jul 2012 | A1 |
20120191190 | Trieu | Jul 2012 | A1 |
20120209388 | Curran et al. | Aug 2012 | A1 |
20120215317 | Curran et al. | Aug 2012 | A1 |
20130006363 | Ullrich et al. | Jan 2013 | A1 |
20130138216 | Curran et al. | May 2013 | A1 |
20130144390 | Curran et al. | Jun 2013 | A1 |
20130245771 | Michelson | Sep 2013 | A1 |
Number | Date | Country |
---|---|---|
2015507 | Jan 1999 | CA |
369603 | May 1990 | EP |
517030 | May 1992 | EP |
667127 | Aug 1995 | EP |
706876 | Apr 1996 | EP |
716840 | Jun 1996 | EP |
737448 | Oct 1996 | EP |
796593 | Sep 1997 | EP |
880938 | Feb 1998 | EP |
809974 | Apr 1998 | EP |
809975 | Apr 1998 | EP |
811356 | Apr 1998 | EP |
9000037 | Jan 1990 | WO |
9106261 | May 1991 | WO |
9214423 | Sep 1992 | WO |
9301771 | Feb 1993 | WO |
9404100 | Mar 1994 | WO |
9410928 | May 1994 | WO |
9501810 | Jan 1995 | WO |
9508306 | Mar 1995 | WO |
9608205 | Mar 1996 | WO |
9617564 | Mar 1996 | WO |
9641582 | Dec 1996 | WO |
9720513 | Jun 1997 | WO |
9733525 | Sep 1997 | WO |
9737620 | Oct 1997 | WO |
9809586 | Mar 1998 | WO |
9814142 | Apr 1998 | WO |
9817208 | Apr 1998 | WO |
9825539 | Jun 1998 | WO |
9908627 | Feb 1999 | WO |
9938461 | Aug 1999 | WO |
0044288 | Aug 2000 | WO |
0045712 | Aug 2000 | WO |
0045713 | Aug 2000 | WO |
0141681 | Jun 2001 | WO |
0149333 | Jul 2001 | WO |
04098380 | Nov 2004 | WO |
07003437 | Jan 2007 | WO |
Entry |
---|
Alleyne, Cargill H., et al., “Current and future approaches to lumbar disc surgery: A literature review”, Medscape Orthopedics & Sports Medicine, 1 [www.medscape.com/Medscape/OrthoSportsMed/1997/v01.n11/.../mos3057], 1997, 14 pages. |
Baulot et al., “Complementary anterior spondylodesis by thoracoscopy. Technical note regarding an observation”, Lyon Surg., 1994, 90(5):347-351. |
Benini et al., “Undercutting decompression and posterior fusion with translaminar facet screw fixation in degenerative lumbar spinal stenosis: Technique and results”, Neuro-Orthopedics, 1995, 17/18, 159-172. |
Berry et al., “A morphometric study of human lumbar and selected thoracic vertebrae, study of selected vertebrae” Spine, 1996, 12(4):362-367. |
CoRoent® XL & XLR Marketing Brochure (9004225 B.0), NuVasive, Inc., 2006, 2 pages. |
CoRoent® XL & XLR Marketing Brochure (9004225 C.0), NuVasive, Inc., 2007, 2 pages. |
CoRoent® XL Marketing Brochure (9500039 A.0), NuVasive, Inc., 2006, 8 pages. |
CoRoent™ Marketing Brochure (9004001 A.0), NuVasive, Inc., 2004, 2 pages. |
CoRoent™ Marketing Brochure (9004001 C.0), NuVasive, Inc., 2005, 2 pages. |
CoRoent™ XL & XLR Marketing Brochure (9004225 A.0), NuVasive, Inc., 2005, 2 pages. |
Counterclaim Defendants' Corrected Amended Invalidity Contentions re U.S. Pat. Nos. 8,000,782; 8,005,535; 8,016,767; 8,192,356; 8,187,334; 8,361,156, D652,922; D666,294 re Case No. 3:12-cv-02738-CAB(MDD), dated Aug. 19, 2013, 30 pages. |
Crock, H. V., “A Short Practice of Spinal Surgery”, Second, revised edition, published by Springer-Verlag/Wein, New York, 1993, 251 pages. |
Crock, H. V., “Anterior Lumbar Interbody Fusion” Clinical Orthopaedics & Related Research, Marshall R. Urist, Editor-in-Chief, J. B. Lippincott Company, 1982, 13 pages. |
Declaration of Mary Phelps Regarding Telamon Verte-Stack PEEK Vertebral Body Spacer, dated Aug. 13, 2013, 9 pages. |
Declaration of Richard A. Hynes, M.D. Regarding U.S. Pat. No. 8,187,334, dated Aug. 14, 2013, 74 pages. |
Declaration of Richard A. Hynes, M.D. Regarding U.S. Pat. No. 8,361,156, dated Aug. 14, 2013, 74 pages. |
Declaration of Steven D. DeRidder regarding U.S. Patent Application Publication No. 2002/0165550, Jul. 30, 2013, 5 pages. |
Edeland, H.G. “Some additional suggestions for an intervertebral disc prosthesis”, Journal of Biomedical Engineering, 1985, 7:57-62. |
Kambin, et al., “History and current status of percutaneous arthroscopic disc surgery”, Spine, 1996, 21(24S):57S-61S. |
Kemp, H. B. S., “Anterior fusion of the spine for infective lesions in adults”, Journal of Bone & Joint Surgery, 1973, 55B(4):715-734. |
Medtronic Sofamor Danek USA, Inc. “Boomerang I Verte-Stack PEEK Vertebral Body Brochure,” 2003, 6 pages. |
Medtronic Sofamor Danek USA, Inc. “Boomerang I Verte-Stack PEEK Vertebral Body Spacer Implant,” Apr. 26, 2001, 8 pages. |
Medtronic Sofamor Danek USA, Inc. “Boomerang II Verte-Stack PEEK Vertebral Body Spacer Brochure,” 2004, 4 pages. |
Medtronic Sofamor Danek USA, Inc. “Boomerang II Verte-Stack PEEK Vertebral Body Spacer Implant,” Dec. 17, 2003, 9 pages. |
Medtronic Sofamor Danek USA, Inc. “Boomerang Prototype Verte-Stack PEEK Vertebral Body Spacer Implant,” May 7, 2000, 8 pages. |
Medtronic Sofamor Danek USA, Inc. “PCR PEEK Cement Restrictor Brochure,” 2001, 2 pages. |
Medtronic Sofamor Danek USA, Inc. “PCR PEEK Cement Restrictor Implant,” Oct. 2, 2001, 17 pages. |
Medtronic Sofamor Danek USA, Inc. “Telamon Verte-Stack PEEK Vertebral Body Spacer Brochure I,” 2003, 2 pages. |
Medtronic Sofamor Danek USA, Inc. “Telamon Verte-Stack PEEK Vertebral Body Spacer Brochure II,” 2003, 10 pages. |
Medtronic Sofamor Danek USA, Inc. “Telamon Verte-Stack PEEK Vertebral Body Spacer Implant,” Oct. 2, 2001, 6 pages. |
NuVasive, Inc., Corrected Final Invalidity Contentions Regarding U.S. Pat. No. 5,860,973, U.S. Pat. No. 6,592,586 and U.S. Pat. No. 6,945,933 filed in the United States District Court, Southern District of California on Jun. 14, 2010 (and 23 appendices). |
Petition for Inter Partes Review of U.S. Pat. No. 8,187,334 Pursuant to 35 U.S.C. 311-319, 37 C.F.R. 42, dated Aug. 14, 2013, 64 pages. |
Petition for Inter Partes Review of U.S. Pat. No. 8,361,156 Pursuant to 35 U.S.C. 311-319, 37 C.F.R. 42, dated Aug. 14, 2013, 64 pages. |
Second Petition for Inter Partes Review of U.S. Pat. No. 8,187,334 Pursuant to 35 U.S.C. 311-319, 37 C.F.R. 42, dated Aug. 14, 2013, 64 pages. |
Second Petition for Inter Partes Review of U.S. Pat. No. 8,361,156 Pursuant to 35 U.S.C. 311-319, 37 C.F.R. 42, dated Aug. 14, 2013, 64 pages. |
Stein et al., “Percutaneous facet joint fusion: Preliminary experience”, Journal of Vascular and Interventional Radiology, 1993, 4:69-74 |
Synthes Vertebral Spacer-PR Brochure, Synthes Spine, 2002, 2 pages. |
Synthesis Spine Vertebral Spacer-PR Implant, Jun. 2002, 2 pages. |
Synthesis Spine Vertebral Spacer-TR Implant, Aug. 2002, 2 pages. |
Telamon Implantation Guide, Medtronic Sofamor Danek, 2003, 10 pages. |
Telamon Verte-Stack PEEK Vertebral Body Spacer Brochure, Medtronic Sofamor Danek, 2003, 2 pages. |
Vamvanij et al., “Surgical treatment of internal disc disruption: An outcome study of four fusion techniques”, Journal of Spinal Disorders, 1998, 11(5):375-382. |
Zhou et al., Geometrical dimensions of the lower lumbar vertebrae-analysis of data from digitised CT images, Eur Spine J, 2000, 9: 242-248. |
Patent Owner NuVasive Inc.'s Preliminary Response in IPR2013-00504, dated Nov. 25, 2013, 40 pages. |
Decision denying Institution of Inter Partesreview in IPR2013-00504, dated Feb. 13, 2014, 9 pages. |
Patent Owner NuVasive Inc.'s Preliminary Response in IPR2013-00506, dated Nov. 25, 2013, 38 pages. |
Decision denying Institution of Inter Partes review in IPR2013-00506, dated Feb. 13, 2014, 21 pages. |
NuVasive Inc's Patent Owner Response in IPR2013-00506, dated May 21, 2014, 66 pages. |
Declaration of Dr. Hansen A. Yuan from IPR2013-00506, dated May 21, 2014, 63 pages. |
Synthes SVS-PR Guide, Synthes Spine, 2002, 8 pages. |
Medtronic Sofamor Danek Boomerang brochure, Medtronic Sofamor Danek, 2003, 6 pages. |
Synthes Vertebral Spacer—AR brochure, Synthesis Spine, 2006, 4 pages. |
Saber Surgical Technique /Product Catalogue, DePuy Spine, 2004, 12 pages. |
Petition for Inter Partes Review of U.S. Pat. No. 8,361,156 Pursuant to 35 U.S.C. 311-319, 37 C.F.R. 42, dated Mar. 5, 2014, 64 pages. |
Patent Owner NuVasive Inc.'s Preliminary Response in IPR2013-00507, dated Nov. 25, 2013, 29 pages. |
Decision denying Institution of Inter Partes review in IPR2013-00507, dated Feb. 13, 2014, 15 pages. |
NuVasive Inc's Patent Owner Response in IPR2013-00507, dated May 21, 2014, 50 pages. |
Declaration of Dr. Hansen A. Yuan from IPR2013-00507, dated May 21, 2014, 85 pages. |
Patent Owner NuVasive Inc.'s Preliminary Response in IPR2013-00508, dated Nov. 25, 2013, 38 pages. |
Decision denying Institution of Inter Partes review in IPR2013-00508, dated Feb. 13, 2014, 14 pages. |
NuVasive Inc's Patent Owner Response in IPR2013-00508, dated May 21, 2014, 66 pages. |
Declaration of Dr. Hansen A. Yuan from IPR2013-00508, dated May 21, 2014, 85 pages. |
Final Written Decision in Medtronic, Inc. v. NuVasive, Inc., Case IPR2013-00507, dated Feb. 11, 2015, 14 pages. |
Final Written Decision in Medtronic, Inc. v. NuVasive, Inc., Case IPR2013-00508, dated Feb. 11, 2015, 19 pages. |
Number | Date | Country | |
---|---|---|---|
61067700 | Feb 2008 | US | |
61105796 | Oct 2008 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 13337967 | Dec 2011 | US |
Child | 14924490 | US | |
Parent | 12380693 | Mar 2009 | US |
Child | 13337967 | US |