Claims
- 1. A process of making diisopinocampheylchloroborane comprising:
- (a) contacting borane methylsulfide in an etheral solvent with (1R)-(+)-.alpha.-pinene, having optical purity of between about 91% ee to 95% ee, to form the diisopinocampheylborane of Formula I, ##STR39## (b) contacting, without further purification, the impure product of step (a) with an acidic chloride to yield diisopinocamphenylchloroborane of Formula 2; ##STR40##
- 2. A process according to claim 1 conducted at from -25.degree. to 25.degree. C., until substaintially complete.
- 3. A process according to claim 2 wherein the etheral solvent is tetrahydrofuran.
- 4. A process for reducing a prochiral ketone to produce an optically active alcohol of high optical purity comprising reacting a prochiral ketone with a diisopinocampheylchloroborane reducing composition said composition being the product of claim 1, said reaction proceeding for from 7 hours to 24 days at a temperature of from -25.degree. C. to ambient temperature and at ambient pressure until the reaction is complete.
Parent Case Info
This is a continuation of application Ser. No. 07/586,933, filed Sep. 24, 1990 abandoned.
Non-Patent Literature Citations (2)
Entry |
J. Org. Chem. 1984, 49, 945-947. |
Chemical Abstracts 104(9):69021r, 1985. |
Continuations (1)
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Number |
Date |
Country |
Parent |
586933 |
Sep 1990 |
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