Mullen (1994) Pharmac. Therap. 63, 199-207.* |
Blau et al. (Nov. 2, 1995) New Eng. J. Med., 1204-107.* |
Mullen (1994) Pharmac. Ther. 63, 199-207.* |
Gutierrez et al (1992) The Lancet 339, 715-721.* |
Orkin et al al (1995) Report and Recommendations of the Panel to Asses the NIH Investment in Research on Gene Therapy.* |
Huber et al (1993) Canc. Res. 53, 4619-4626.* |
Colombo et al (1995) Human Gene Therapy 6, 763-772 (cited in patent 08/242,193).* |
Barba et al (1994) Proced. Natl. Acad. Sci. 91, 4348-4352. (cited in patent 08/242,193).* |
Culver et al (1992) Science 256, 1550-1552. (cited in patent 08/242,193).* |
Ram et al (1993) Canc. Res. 53, 83-88. (cited in patent 08/242,193).* |
Rosenstein, J.M., “Neocortical Transplants in the Mammalian Brain Lack a Blood-Brain Barrier to Macromolecules,” Science 235:772-774 (1987) (Exhibit 1). |
Anderson, W.F., “Prospects for Human Gene Therapy,” Science 226:401-409 (1984) (Exhibit 2). |
Friedmann, T. & Roblin, R., “Gene Therapy for Human Genetic Disease?”, Science 175:949-955 (1972) (Exhibit 3). |
Rosenberg, S.A. et al., “A New Approach to the Adoptive Immunotherapy of Cancer With Tumor-Infiltrating Lymphocytes,” Science 233:1318-1321 (1986) (Exhibit 4). |
Wolff, J.A., et al., “Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease,” Proc.Natl.Acad.Sci.USA (1989) 86:9011-9014 (Exhibit 5). |
Moolten, F.L. et al., “Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transferred by Retroviral Vectors,” Journal of the National Cancer Institute, Reports 82 (4):297-300 (1990) (Exhibit 6). |
Moolten, F.L., “Tumor Chemosensitivity Conferred by Inserted Herpes Thymidine Kinase Genes: Paradigm for a Prospective Cancer Control Strategy,” Cancer Research 46:5276-5281 (1986) (Exhibit 7). |
Gage, F.H. et al., “Implantation of genetically engineered cells to the brain,” Progress in Brain Research 78:651-658 (1988) (Exhibit 8). |
Yee, J.-K. et al., “Gene Expression from a Transcriptionally Disabled Retroviral Vector,” Cold Spring Harbor Symposia on Quantitative Biology 51:1021-1026 (1986) (Exhibit 9). |
Wolff, J.A. et al., “Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes,” Proc.Natl.Acad.Sci.USA 84:3344-3348 (1987) (Exhibit 10). |
Jolly, D.J. et al., “Cell Targeting Techniques—High Efficiency Gene Transfer into Cells” Methods in Enzymology 149:10-25 (1987) (Exhibit 11). |
Miller, A.D. et al., “Generation of Helper-Free Amphotropic Retroviruses That Transduce a Dominant-Acting, Methotrexate-Resistant Dihydrofolate Reductase Gene,” Molecular and Cellular Biology 5(3):431-437 (1985) (Exhibit 12). |
Eglitis, M.A. & Anderson, W.F., “Retroviral Vectors for Introduction of Genes into Mammalian Cells,” BioTechniques 6(7):608-614 (1988) (Exhibit 13). |
Bender, M.A. et al., “Evidence that the Packaging Signal of Moloney Murine Leukemia Virus Extends into the gag Region,” Journal of Virology 61(5):1639-1646 (1987) (Exhibit 14). |
Howell, S.B. et al., “Gene Therapy for Thioguanine-resistant Human Leukemia,” Mol.Biol.Med. 4:157-168 (1987) (Exhibit 15). |
Das, G.D., “Intraparenchymal Transplantation,” Neural Grafting in the Mammalian CNS 3:23-30 (1985) (Exhibit 16). |
Freed, W.J., “Transplantation of Tissues to the Cerebral Ventricles: Methodological Details and Rate of Graft Survival,” Neural Grafting in the Mammalian CNS 4:31-40 (1985) (Exhibit 17). |
Brundin, P. et al., “Intracerebral Grafts of Neuronal Cell Suspensions,” Neural Grafting in the Mammalian CNS 6:51-59 (1985) (Exhibit 18). |
David, S. & Aguayo, A.J., “Peripheral Nerve Transplantation Techniques to Study Axonal Regeneration From the CNS of Adult Mammals,” Neural Grafting in the Mammalian CNS 7:61-69 (1985) (Exhibit 19). |
Seiger, A., “Preparation of Immature Central Nervous System Regions for Transplantation,” Neural Grafting in the Mammalian CNS 8:71-77 (1985) (Exhibit 20). |
Mann, R. et al., “Construction of Retrovirus Packaging Mutant and Its Use to Produce Helper-Free Defective Retrovirus,” Cell 153-159 (1983) (Exhibit 21). |
Shimohama, S. et al., Grafting genetically modified cells into the rat brain: characteristics of E. coli β-galactosidase as a reporter gene (1989) 5:271-278 (Exhibit 22). |
Culver, K.W. et al., “In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors,” Science 256:1550-1552 (1992) (Exhibit 23). |
Ram, Z. et al., “In Situ Retroviral-mediated Gene Transfer for the Treatment of Brain Tumors in Rats,” Cancer Research 53:83-88 (1993) (Exhibit 24). |
Z.D. Ezzedine et al. (Jun. 1991) “Selective Killing of Glioma Cells in Culture and in Vivo by Retrovirus Transfer of the Herpes Simplex Virus Tymidine Kinase Gene” The New Biologist 3(6):608-614. (Exhibit 25). |
Short et al. (1990) “Gene Delivery to Glioma Cells in Rat Brain by Grafting of a Retrovirus Packaging Cell Line,” Journal of Neuroscience Research 27:427-433 (Exhibit 26). |
Moolten & Brodeur, Proc. Am. Assoc. Cancer Res. 29:461 (1988) (Exhibit 17). |
Friedmann, Gene Therapy Fact and Fiction, Cold Spring Harbor Laboratory, New York (1983) (Exhibit 18). |
Barba et al., Proc. Natl. Acad. Sci. USA, 91:4348-4352 (1994) (Exhibit 19). |