1. Technical Field
The present disclosure relates to electrosurgical instruments used for open and endoscopic surgical procedures for sealing or fusing tissue. More particularly, the present disclosure relates to a bipolar forceps for sealing vessels, vascular tissues and soft tissues having an electrode sealing assembly which is designed to limit and/or reduce by rapid cooling thermal spread to adjacent tissue structures.
2. Related Prior Art
Electrosurgical forceps utilize both mechanical clamping action and electrical energy to effect hemostasis by heating the tissue and blood vessels to coagulate and/or cauterize vessels or tissue. However, certain surgical procedures may require sealing blood vessels or vascular tissue rather than just simply effecting hemostasis. “Vessel sealing” or “Tissue Fusion” is defined as the process of liquefying the collagen, elastin and ground substances in the tissue so that it reforms into a fused mass with significantly-reduced demarcation between the opposing tissue structures. In contrast, the term “cauterization” is defined as the use of heat to destroy tissue (also called “diathermy” or “electrodiathermy”) and the term “coagulation” is defined as a process of desiccating tissue wherein the tissue cells are ruptured and dried. Coagulation of small vessels is usually sufficient to permanently close them. Larger vessels or tissue need to be “sealed” to assure permanent closure.
Numerous electrosurgical instruments have been proposed in the past for various open and endoscopic surgical procedures. However, most of these instruments cauterize or coagulate tissue and are normally not designed to provide uniformly reproducible pressure on the blood vessel or tissue which, if used for sealing purposes, would result in an ineffective or non-uniform seal. For example, U.S. Pat. No. 2,176,479 to Willis, U.S. Pat. Nos. 4,005,714 and 4,031,898 to Hiltebrandt, U.S. Pat. Nos. 5,827,274, 5,290,287 and 5,312,433 to Boebel et al., U.S. Pat. Nos. 4,370,980, 4,552,143, 5,026,370 and 5,116,332 to Lottick, U.S. Pat. No. 5,443,463 to Stern et al., U.S. Pat. No. 5,484,436 to Eggers et al. and U.S. Pat. No. 5,951,549 to Richardson et al., all relate to electrosurgical instruments for coagulating, cauterizing, and cutting vessels or tissue.
Many of these instruments include blade members or shearing members which simply cut tissue in a mechanical and/or electromechanical manner and are relatively ineffective for vessel sealing purposes. Other instruments generally rely on clamping pressure alone to procure proper sealing thickness and are often not designed to take into account gap tolerances and/or parallelism and flatness requirements which are parameters which, if properly controlled, can assure a consistent and effective tissue seal. For example, it is known that it is difficult to adequately control thickness of the resulting sealed tissue by controlling clamping pressure alone for either of two reasons: 1) if too much force is applied, there is a possibility that the two poles will touch and energy will not be transferred through the tissue resulting in an ineffective seal; or 2) if too low a force is applied, a thicker less reliable seal is created.
Commonly-owned U.S. Application Serial Nos. PCT Application Serial No. PCT/US01/11340 filed on Apr. 6, 2001 by Dycus, et al. entitled “VESSEL SEALER AND DIVIDER”, U.S. application Ser. No. 10/116,824 filed on Apr. 5, 2002 by Tetzlaff et al. entitled “VESSEL SEALING INSTRUMENT” and PCT Application Serial No. PCT/US01/11420 filed on Apr. 6, 2001 by Tetzlaff et al. entitled “VESSEL SEALING INSTRUMENT” teach that to effectively seal tissue or vessels, especially large vessels, two predominant mechanical parameters must be accurately controlled: 1) the pressure applied to the vessel; and 2) the gap distance between the conductive tissue contacting surfaces (electrodes). As can be appreciated, both of these parameters are affected by the thickness of the vessel or tissue being sealed. Accurate application of pressure is important for several reasons: to reduce the tissue impedance to a low enough value that allows enough electrosurgical energy through the tissue; to overcome the forces of expansion during tissue heating; and to contribute to the end tissue thickness which is an indication of a good seal.
It has been found that using electrosurgical instruments to seal tissue may result in some degree of so-called “thermal spread” across adjacent tissue structures. “Thermal spread” refers generally to the heat transfer traveling along the periphery of the electrically conductive surfaces. This can also be termed “collateral damage” to adjacent tissue. As can be appreciated, reducing the thermal spread during an electrical procedure reduces the likelihood of unintentional or undesirable collateral damage to surrounding tissue structures which are adjacent to an intended treatment site. Reducing the collateral damage to surrounding tissue or maintaining the viability of surrounding tissue after the sealing process is known to promote tissue healing and decrease overall healing time by stimulating/improving healing response. Controlling tissue cooling may also reduce adhesion or buildup of tissue on the electrodes and also assist during the formation of the tissue seal, e.g., cross-linking or other chemical bonding, during the reformation or renaturation of collagen.
Instruments which include dielectric coatings disposed on the outer surfaces are known and are used to prevent tissue “blanching” at points normal to the sealing site. In other words, these coatings are primarily designed to reduce accidental burning of tissue as a result of incidental contact with the outer surfaces of the end effectors. So far as is known, these coatings are not designed or intended to reduce collateral tissue damage or thermal spread to adjacent tissue (tissue lying along the tissue plane).
Commonly-owned U.S. patent Ser. No. 10/474,168 entitled “ELECTROSURGICAL INSTRUMENT WHICH REDUCES COLLATERAL DAMAGE TO ADJACENT TISSUE” filed on Oct. 3, 2003 by Buysse et al. relates to an instrument which is configured to control or regulate the electrical field around the electrically conductive sealing surfaces to reduce stray current concentrations which can result in thermal spread to adjacent tissue structures.
Thus, a need exists to develop an electrosurgical instrument which includes an electrode sealing assembly which can seal vessels and tissue consistently and effectively and reduce the undesirable effects of thermal spread across or to adjacent tissue structures by utilizing a thermally conductive, electrically non-conductive material.
In addition, in tissue fusion applications that utilize energy to treat tissue, the need exists to maximize and enhance tissue strength at the tissue fusion site and minimize detrimental tissue effects to adjacent or surrounding tissue structures.
It is an object of the present disclosure to provide an electrode sealing assembly designed for use with an electrosurgical instrument for sealing tissue which rapidly cools during or after tissue fusion heating processes.
The present disclosure generally relates to an electrode sealing assembly for use with an electrosurgical instrument for sealing tissue. The electrode sealing assembly includes first and second jaw members which are movable from a first position in spaced relation relative to one another to at least one second position for grasping tissue therebetween. The jaw members include electrically conductive sealing plates disposed in opposing relation to one another. At least one jaw member includes a thermoelectric cooling plate having a first surface in direct contact with an outer surface of the sealing plate. The thermoelectric cooling plate include first and second electrical connections disposed on opposite sides of the thermoelectric cooling plate. The first connection is configured to selectively transmit a first electrical potential and the second connection is configured to selectively transmit a second electrical potential such that heat generated by the sealing plates is transferred away from the tissue via the thermoelectric cooling plate.
The heat sink may be configured to be coupled to an ultimate heat sink for transferring heat from the jaw member(s). The heat sink may include a coolant line disposed therethrough. The coolant line may be configured to receive a coolant to transfer heat from the thermoelectric cooling plate. In one embodiment, the coolant is a thermally conductive, non-electrically conductive fluid which may be one of the group consisting of air, nitrogen, carbon dioxide, and 3M™ Fluorinert™ Electronic Liquid FC-7 (available from 3M Company, St. Paul, Minn.).
In one particularly useful embodiment, the present disclosure relates to an electrode sealing assembly designed for use with an electrosurgical instrument for sealing tissue. The electrode sealing assembly includes first and second electrode jaw members which are movable from a first position in spaced relation relative to one another to at least one second position for grasping tissue therebetween. The jaw members include sealing plates disposed in opposing relation relative to one another. Each jaw member includes a cooling line disposed therethrough which is configured to convey a cooling liquid therethrough to absorb heat from the sealing plates during or after sealing.
The cooling line may be configured to be coupled to a second or an ultimate heat sink for transferring heat from the jaw member(s). In addition, the coolant line may be configured to receive a coolant to transfer heat from the jaw member(s). In one embodiment, the coolant is a thermally conductive, non-electrically conductive fluid.
In another particularly useful embodiment, the present disclosure relates to an electrode sealing assembly designed for use with an electrosurgical instrument for sealing tissue, which includes: first and second jaw members being movable from a first position in spaced relation relative to one another to at least one second position for grasping tissue therebetween. Each of the jaw members includes: an insulating housing having at least one electromechanical interface; and an electrically conductive sealing plate having at least one corresponding electromechanical interface which mates with the electromechanical interface of the insulating housing. The insulating housing has a coolant duct disposed therethrough which is configured to transport a coolant to the insulating housing to dissipate heat away from surrounding tissue.
In another embodiment, the coolant duct is configured to transport the coolant through one or more nozzle(s) disposed on an upper surface of the insulating housing. The nozzle(s) are configured to discharge the coolant to an environment proximate the electrode sealing assembly. In another embodiment, the coolant duct is configured to transport the coolant through the insulating housing to an ultimate heat sink.
Various embodiments of the subject instrument are described herein with reference to the drawings wherein:
It has been found that by providing a thermally conductive and electrically non-conductive material adjacent to the electrically conductive sealing surfaces, surgeons can more readily and more easily produce a consistent, high quality seal and effectively reduce thermal spread across or to adjacent tissue. For the purposes herein the term “thermal spread” refers generally to the heat transfer (heat conduction, heat convection or electrical current dissipation) dissipating along the periphery of the electrically conductive or electrically active surfaces to adjacent tissue. This can also be termed “collateral damage” to adjacent tissue and is further discussed in commonly owned, co-pending PCT Patent Application PCT/US04/13273 entitled “ELECTROSURGICAL INSTRUMENT WHICH REDUCES THERMAL DAMAGE TO ADJACENT TISSUE” which is incorporated herein by reference in its entirety.
It is envisioned that the configuration of the thermally conductive material which surrounds the perimeter of the electrically conductive surface will effectively absorb heat during electrosurgical activation (or thermally dissipate the heat during electrosurgical activation) and generally restrict heat travel to areas between the opposing electrically conductive surfaces. In other words, the material acts like a so called “heat sink”. As mentioned above, the thermally conductive material is also electrically non-conductive which also restricts current concentrations to between the two opposing surfaces.
It is important to note that this is different from dielectrically coating the outer surfaces of the instrument to prevent tissue “blanching” at points normal to the sealing site. These coatings are not designed or intended to reduce collateral tissue damage or thermal spread to adjacent tissue (tissue lying along the tissue sealing plane).
It is contemplated that by providing a thermally conductive material adjacent to the electrically conductive surface, the thermally conductive path is altered thereby influencing the thermal spread/collateral damage to adjacent tissue structures. In addition, the thermally conductive, electrically non-conductive material also isolates the two electrically opposing poles (i.e., electrodes) from one another thereby reducing the possibility that tissue or tissue fluids can create an unintended bridge or path for current travel to adjacent tissue. The thermally conductive material and electrically conductive sealing surface may be dimensioned such that the current is concentrated at the intended sealing site between the opposing electrically conductive surfaces as explained in more detail below.
It is contemplated that by providing additional cooling of the electrosurgical jaw members of the bipolar forceps such as by solid state cooling via thermoelectric coolers (TEC) based on the Peltier effect, the thermal spread/collateral damage to adjacent tissue structures may also be further reduced. It is further contemplated that additional cooling may be provided to the electrosurgical jaw members via a cooling duct passing internally through the jaw members.
Referring now to
Forceps 10 also includes a plug 300 which connects the forceps 10 to a source of electrosurgical energy, e.g., an electrosurgical generator (not shown) via an electrical cable 310. Handle assembly 30 includes a fixed handle 50 and a movable handle 40. Handle 40 moves relative to fixed handle 50 to actuate the end effector assembly 100 and enable a user to grasp and manipulate tissue 400 (See
The housing 20 encloses a drive assembly (not shown) which cooperates with the movable handle 40 to impart movement of the jaw members 110 and 120 from the open position to the clamping or closed position. The handle assembly 30 can generally be characterized as a four-bar mechanical linkage which provides a unique mechanical advantage when sealing tissue between the jaw members 110 and 120. For example, once the desired position for the sealing site is determined and the jaw members 110 and 120 are properly positioned, handle 40 may be compressed fully to lock the jaw members 110 and 120 in a closed position against the tissue. The details relating to the inter-cooperative relationships of the inner-working components of forceps 10 are disclosed in commonly-owned U.S. patent application Ser. No. 10/284,562 and U.S. patent application Ser. No. 10/460,926 which are both incorporated in their entirety by reference herein. When the jaw members 110 and 120 are fully compressed about the tissue, the forceps 10 is now ready for selective application of electrosurgical energy.
Experimental results suggest that the magnitude of pressure exerted on the tissue by the electrically conductive sealing surfaces 112, 122 of the jaw members 110 and 120, respectively, is important in assuring a proper surgical seal. Pressures within a working range of about 3 kg/cm2 to about 16 kg/cm2 and, preferably, within a working range of about 6 kg/cm2 to about 13 kg/cm2 have been shown to be effective for sealing various tissue types. Most preferably, the pressures are within a working range of about 4.5 kg/cm2 to about 8.5 kg/cm2 to optimize sealing.
An open forceps 10′ for use in connection with traditional open surgical procedures and is shown by way of example in
Each shaft 12a′ and 12b′ may include a handle 17a′ and 17b′ disposed at the proximal end 16a′ and 16b′ thereof which each define a finger hole 18a′ and 18b′, respectively, therethrough for receiving a finger of the user. As can be appreciated, finger holes 18a′ and 18b′ facilitate movement of the shafts 12a′ and 12b′ relative to one another which, in turn, pivot the jaw members 110′ and 120′ from the open position wherein the jaw members 110′ and 120′ are disposed in spaced relation relative to one another for manipulating tissue to a clamping or closed position wherein the jaw members 110′ and 120′ cooperate to grasp tissue therebetween.
A ratchet 30′ is included for selectively locking the jaw members 110′ and 120′ relative to one another at various positions during pivoting. Preferably, each position associated with the cooperating ratchet interfaces 30′ holds a specific, i.e., constant, strain energy in the shaft members 12a′ and 12b′ which, in turn, transmits a specific closing force to the jaw members 110′ and 120′. It is envisioned that the ratchet 30′ may include graduations or other visual markings which enable the user to easily and quickly ascertain and control the amount of closure force desired between the jaw members 110′ and 120′. One of the shafts, e.g., 12b′, includes a proximal shaft connector Mange 19′ which is designed to connect the forceps 10′ to a source of RF energy (not shown) via an electrosurgical cable 310 and plug 300. The details relating to the inner-working electrical connections and various components of forceps 10′ are disclosed in commonly-owned U.S. patent application Ser. No. 10/369,894 which is incorporated in its entirety by reference herein.
As mentioned above, two mechanical factors play an important role in determining the resulting thickness of the sealed tissue and effectiveness of the seal, i.e., the pressure applied between opposing jaw members 110′ and 120′ and the gap between the opposing jaw members 110′ and 120′ during the sealing process. Applying the correct force is also important for other reasons: to reduce the impedance of the tissue to a low enough value that allows enough current through the tissue; and to overcome the forces of expansion during the heating of the tissue in addition to contributing towards creating the required seal thickness necessary for a good seal.
For the purposes herein, electrode assemblies 100 and 100′ include the same general configuration and are designed to reduce thermal spread to adjacent tissue. However, certain modifications may have to be made to each electrode sealing assembly 100 (or 100′) to fit the electrode sealing assembly 100 (or 100′) to a specific support structure for an open or endoscopic instrument. By controlling the intensity, frequency and duration of the RF energy applied to the tissue, the user can selectively seal the tissue as needed for a particular purpose. As can be appreciated, different tissue types and the physical characteristics associated with each tissue type may require different electrical sealing parameters.
More particularly, lower jaw member 120 includes an insulated outer housing 114 which supports a thermally conductive, electrically non-conductive material 128 and electrically conductive sealing surface or sealing plate 122. As best seen in
Each electromechanical interface, e.g., 125a, is electrically connected to an electrical potential by way of wire 160 which extends to the generator (not shown). It is envisioned that other electrical configurations are plausible as is known in the art and the above is shown by way of example. For example, electrically conductive tubes or plates may be utilized within the jaw members 110 and 120 to supply current to the sealing plate 122.
Support surface 115 also includes a series of notches 137, 121a, 121b and screw holes 138 which secure the insulating housing 114 to the electrode sealing assembly 100. For example, and as best shown in
Thermally conductive material 128 is may be made from two laterally-opposing segments 128a and 128b which mate to encompass the sealing plate 122 and the support step 127 as best seen in
As mentioned above, the thermally conductive material 128 is also electrically non-conductive which also restricts current concentrations to between the two opposing sealing plates 122. The thermally conductive material 128 may be made from a material having a high thermal conductivity value or “k” value and minimum electrical conductively, e.g., anodized aluminum. Alternatively, the thermally conductive material 128 may also be made from or combined with a semi-resilient or elastomeric material so as not to inflict mechanical damage to the tissue during compression. Mechanical damage may also be diminished by minimizing the overall tissue contact area of the thermally conductive material 128 (See, e.g.,
Other compression-reducing systems are also envisioned to avoid over-compression of tissue adjacent the sealing plates 122 and between the opposing thermally conductive materials 128, e.g., rubber-like inserts, foam or the like. Other examples of thermally conductive and electrically non-conductive materials which can be utilized to minimize thermal damage to surrounding tissue include, but are not limited to: thermally conductive plastic materials which dissipate heat along a preferred isothermal profile to the surrounding environment resulting in a lower maximum temperature and reduced formation of hot spots. Examples of such materials are commonly sold under the trademark CoolPoly® by Cool Polymers, Inc., of Rhode Island and composite materials such as ALO2.
As mentioned above, the thermally conductive material 128 includes two segments 128a and 128b which mate about the sealing plate 122 and the support step 127. More particularly, each segment 128a and 128b includes a tissue contacting surface 143a and 143b with a recessed portion 129a and 129b, respectively, along an inner peripheral edge of the tissue contacting surface 143a and 143b such that, once the two segments 128a and 128b are assembled they form a slot 141 for seating the sealing plate 122 therein. The sealing plate 122 is typically seated to lie generally flush with or below the tissue contacting surfaces 143a, 143b of the thermally conductive segments 128a and 128b. It is also envisioned that the thickness (or height relative to the insulating housing 114) of the thermally conductive material 128 proximate the recessed portions 129a, 129b is about equal to the height of the step 127 plus the thickness of the sealing plate 122 such that, once assembled, the sealing plate 122 and the thermally conductive material 128 lie substantially flush or below within the sealing plane.
The thermally conductive segments 128a and 128b may also include a series of fin-like extensions 145a, 145b, 145c and 146a, 146b, 146c, respectively, which extend laterally therefrom. It is envisioned that the fin-like extensions 145a, 145b, 145c and 146a, 146b, 146c further absorb or dissipate heat emanating from the sealing plates 122 during or after activation. The fins 145a, 145b, 145c and 146a, 146b, 146c may also be shaped and dimensioned to facilitate manufacturing and assembly, i.e., the fins 145a, 145b, 145c and 146a, 146b, 146c may be shaped to include slots 132 therein which allow passage of one or more screws 135a, 135b which attach the insulating housing 114 to the underlying electrode sealing assembly 100.
As mentioned above, the sealing plate 122 is electromechanically connected to the underlying insulating housing 114 by virtue of a series of electro-mechanical interfaces 123a, 123b and 123c which project outwardly therefrom to mate with a series of corresponding electromechanical interfaces 125a, 125b and 125c. It is envisioned that the electromechanical interfacing elements 123a, 123b, 123c and 125a, 125b, 125c maintain electrical continuity from the insulating housing 114 to the sealing plate 122. As mentioned above, once assembled and interfaced with the insulating housing 114, the thermally conductive material 128 encapsulates and further secures the sealing plate 122 atop the insulating housing 114.
A series of stop members 150a, 150b and 150c may be disposed on the tissue contacting surfaces or the inner-facing surfaces of the electrically conductive sealing plates 122 (and/or the opposite sealing plate 112 (See
Stop members 150a-150c are typically made from an insulative material, e.g., parylene, nylon and/or ceramic. The stop members 150a-150c can be disposed on one or both of the jaw members 110 and 120 and may be dimensioned in a variety of different shapes and sizes, e.g., longitudinal, circular, ridge-like, etc.
The non-conductive stop members 150a-150c are molded onto the sealing plates 112 and 122 (e.g., overmolding, injection molding, etc.), stamped onto the sealing plates 112 and 122, deposited (e.g., plasma deposition) onto the sealing plates 112 and 122 and/or thermally sprayed onto the surface of the sealing plates 112 and 122 (e.g., a ceramic material may be thermally sprayed) to form the stop members 150a-150c. Many different configurations for the stop members 150a-150c are discussed in detail in commonly-assigned, co-pending U.S. Application Serial No. PCT/US01/11413 entitled “VESSEL SEALER AND DIVIDER WITH NON-CONDUCTIVE STOP MEMBERS” by Dycus et al. which is hereby incorporated by reference in its entirety herein.
It is also envisioned that the thermally conductive material 128 may be dimensioned thicker than the height of step 127 and the thickness of the sealing plate 122 such that the thermally conductive material 128 acts like a stop member for maintaining a gap distance between the sealing plates 122 during activation.
In addition to keeping the pressure within a working range (i.e., about 3 kg/cm2 to about 16 kg/cm2) and the gap distance within a specified range (i.e., about 0.001 inches to about 0.012 inches for large tissue structures) the electrical power should be kept within the range of about 1 W to about 350 W, about 1 Vrms to about 400 Vrms and about 0 Amps to about 5.5 Amps.
Thermal spread on each side of the sealing plates 122 is ideally kept to less than about 2 mm and preferably to less than about 0.5 mm to promote tissue healing. However, when sealing larger or well-vascularized tissue structures, thermal spread is acceptable to about 5 mm. It is envisioned that maintaining the viability of tissue surrounding or adjacent the sealing site or fused tissue area will promote healing.
The coolant ducts 355, 355a, 355b supply active cooling liquid (preferably, non-electrically conductive cooling liquid) or gas (e.g., air) 370 through at least one of a series of nozzles or ports 350a and 350b disposed on an upper surface 330 of the insulating housing 314. The nozzles or ports 350a and 350b are located immediately adjacent the sealing plate 122 and extend longitudinally on opposite sides thereof, i.e., ports 350a extend along one side of the sealing plate 122 and ports 350b extend along the opposite side of the sealing plate 122. The nozzles or ports 350a and 350b are configured to discharge the coolant 370 to an environment proximate the electrode sealing assembly 100 (or 100′).
As can be appreciated, the sealing system 340 supplies coolant (liquid or gas (e.g., air)) 370 to the tissue areas adjacent the sealing plates 122 to actively cool the tissue during activation which reduces thermal spread. With respect to this particular embodiment and compared to the embodiments of
It is envisioned that the jaw members 110 and 120 may be curved in order to reach specific anatomical structures and promote more consistent seals for certain procedures. For example, it is contemplated that dimensioning the jaw members 110 and 120 at an angle of about 45 degrees to about 70 degrees is preferred for accessing and sealing specific anatomical structures relevant to prostatectomies and cystectomies, e.g., the dorsal vein complex and the lateral pedicles. Other angles may be preferred for different surgical procedures.
For example and as best shown in
It is also envisioned that the jaw members 110 and 120 may be tapered which is advantageous for two reasons: 1) the taper will apply constant pressure for a constant tissue thickness at parallel; 2) the thicker proximal portion of each jaw member 110 and 120 will resist bending due to the reaction force of the tissue 400.
It is also envisioned that the above forceps 10 (or 10′) may be utilized in connection with a closed-loop RF control system which optimizes sealing based upon pre-surgical conditions or changes in physical or electrical conditions during sealing. One example of a closed-loop control system is described in commonly-owned U.S. patent application Ser. No. 10/427,832 filed on May 1, 2003 entitled “METHOD AND SYSTEM FOR CONTROLLING OUTPUT OF RF MEDICAL GENERATOR” and commonly-owned U.S. patent application Ser. No. 10/835,657 filed on Apr. 30, 2004 entitled “METHOD AND SYSTEM FOR PROGRAMMING AND CONTROLLING AN ELECTROSURGICAL GENERATOR SYSTEM” which are both incorporated in their entirety by reference herein. In general, the closed-loop control, system includes a user interface for allowing a user to select at least one pre-surgical parameter, such as the type of surgical instrument operatively connected to the generator, the type of tissue and/or a desired surgical effect. A sensor module is also included for continually sensing at least one of electrical and physical properties proximate the surgical site and generating at least one signal relating thereto.
The closed loop control system also includes a control module for continually receiving or monitoring surgical parameters and each of the signals from the sensor module and processing each of the signals in accordance with a desired surgical effect using a microprocessor, computer algorithm and/or a look-up table. The control module generates at least one corresponding control signal relating to each signal from the sensor module(s), and relays the control signal to the electrosurgical generator for controlling the generator. The closed loop system may be employed in a feedback circuit or part of a surgical method for optimizing a surgical seal. The method includes the steps of: applying a series of electrical pulses to the surgical site; continually sensing electrical and physical properties proximate the surgical site; and varying pulse parameters of the individual pulses of the series of pulses in accordance with the continually-sensed properties. Alternatively, the signal may be continuous.
It is also contemplated that the sealing surfaces 122 of the jaw members 110 and 120 can be made from or coated with non-stick materials to reduce tissue adhesion. Alternatively, the jaw members 110 and 120 may be surface treated, roughened, to reduce sticking, e.g., bead blasting, stamping. When utilized on the sealing surfaces 122, these materials provide an optimal surface energy for eliminating sticking due in part to surface texture and susceptibility to surface breakdown due to electrical effects and corrosion in the presence of biologic tissues. It is envisioned that these materials exhibit superior non-stick qualities over stainless steel and should be utilized on the forceps 10 (or 10′) in areas where the exposure to pressure and RF energy can create localized “hot spots” more susceptible to tissue adhesion. As can be appreciated, reducing the amount that the tissue “sticks” during sealing improves the overall efficacy of the instrument. Controlling tissue cooling may also reduce adhesion or buildup of tissue on the electrodes and also assist during the formation of the tissue seal, e.g., cross-linking or other chemical bonding, during the reformation or renaturation of collagen.
The non-stick materials may be manufactured from one (or a combination of one or more) of the following “non-stick” materials: nickel-chrome, chromium nitride, MedCoat 2000, Inconel 600, tin-nickel or various nitride coatings which include, but are not limited to, TiN, ZrN, TiAlN and CrN. For example, high nickel chrome alloys, Ni200, Ni201 (˜100% Ni) may be made into electrodes or sealing surfaces by metal injection molding, stamping, machining or any like process. Also and as mentioned above, the sealing surfaces 122 may also be “coated” with one or more of the above materials to achieve the same result, i.e., a “non-stick surface”.
It is further envisioned that thermal spread may be reduced by altering the physical dimensions of the insulating housing 114. For example, in some cases it may be preferable to manufacture the insulating housing 114 from a variety of materials (either alone or in combination) which include: nylons and syndiotactic polystryrenes such as QUESTRAe manufactured by DOW Chemical; Polybutylene Terephthalate (PBT); Polycarbonate (PC); Acrylonitrile Butadiene Styrene (ABS); Polyphthalamide (PPA); Polymide, Polyethylene Terephthalate (PET); Polyamide-imide (PAI); Acrylic (PMMA); Polystyrene (PS and HIPS); Polyether Sulfone (PES); Aliphatic Polyketone; Acetal (POM) Copolymer; Polyurethane (PU and TPU); Nylon with Polyphenylene-oxide dispersion; and Acrylonitrile Styrene Acrylate.
It is also contemplated that only one of the two jaw members 110 and 120 may include one of the aforedescribed mechanisms or configurations for reducing thermal spread. For example and with reference to
It is envisioned that the forceps 10 or 10′ may be designed such that it is fully or partially disposable depending upon a particular purpose or to achieve a particular result. For example, electrode sealing assembly 100 may be selectively and releasably engageable with the distal end 14 of the shaft 12 and/or the proximal end 16 of shaft 12 may be selectively and releasably engageable with the housing 20 and the handle assembly 30. In either of these two instances, the forceps 10 would be considered “partially disposable” or “reposable”, i.e., a new or different electrode sealing assembly 100 (or electrode sealing assembly 100 and shaft 12) selectively replaces the old jaw assembly 110 as needed.
Another embodiment of an electrode cooling system for an electrode assembly 700 according to the present disclosure is illustrated in
During the tissue sealing process, heat Q is generated on inner surface 727a, 727b in the generally flat central portion 710a, 710b of electrically conductive seal plates 712a and 712b. Similarly, heat Q′ is generated on inner surface 729a, 729b in the generally flat central portion 720a, 720b of electrically conductive seal plates 722a and 722b.
At least one of the jaw members 710 and 720 includes a thermoelectric plate such that heat generated by at least one of the jaw members is transferred away from the tissue via the thermoelectric plate. More particularly, a first surface 730 of an upper thermoelectric (TEC) plate 718 and an outer surface 714a, 714b of the upper electrically conductive seal plates 712a, 712b in the generally flat central portion 710a, 710b have a thermally conductive, electrically insulating material 780 disposed therebetween. Correspondingly, a first surface 740 of a lower thermoelectric (TEC) plate 728 and an outer surface 724a, 724b of the lower electrically conductive seal plates 722a, 722b in the generally flat central portion 720a, 720b have a thermally conductive, electrically insulating material 782 disposed therebetween.
The heat Q generated on inner surface 727a, 727b of upper jaw member 710 is transferred through the upper electrically conductive seal plates 712a, 712b and through the thermally conductive, electrically insulating material 780 to the first surface 730 of the upper TEC plate 718 where the heat Q is transferred to the TEC plate 718.
Similarly, the heat Q generated on inner surface 729a, 729b of upper jaw member 720 is transferred through the lower electrically conductive seal plates 722a, 722b and through the thermally conductive, electrically insulating material 782 to the first surface 740 of the lower TEC plate 728 where the heat Q is transferred to the TEC plate 728.
It is contemplated that in most cases of electrosurgery, both of the jaw members 710 and 720 would include their respective TEC plates 718 and 728 for cooling purposes. Furthermore, those skilled in the art will recognize that TEC plates 718 and 728 may be alternatively referred to as solid state heat pumps or Peltier coolers.
As shown in
The TEC plates 718 and 728 provide the capability of directing this heat Q away from the inner surfaces 727a, 727b and 729a, 729b depending upon direction of current flow through the electrical leads. In most cases of electrosurgery, the TEC plates would be used for cooling rather than heating. To achieve cooling, direction of current is controlled by the power supply 756 and current is directed through the TEC plates 718 and 728 such that the heat Q from the seal plates 712a, 712b, 722a, 722b is directed away from the tissue and towards the opposite end of the TEC plates 718 and 728. As can be appreciated, the heat Q generated during tissue sealing by the electrodes 710 and 720 is transferred away from the tissue and is not transmitted to surrounding tissue, thus reducing collateral damage to tissue. The thermally conductive, electrically insulating materials 780, 782 may be made of a cool polymer as described previously which prevents electrical continuity between the DC power supply 756 and an AC power supply from the previously discussed source of electrosurgical energy e.g., an electrosurgical generator (not shown) via plug 300 and electrical cable 310 (see
It is envisioned that a first electrical potential 758 may be selectively transmitted through leads 765a, 765b and 765c and a second electrical potential 759 may be selectively transmitted through leads 766a, 766b, and 766c such that different electrical potentials are created on opposite sides of the plate 718. As can be appreciated, heat Q in this instance may be directed proximally for absorption by a second heat sink, e.g., cool polymer, a fluid through one or more ducts 854 disposed in contact with TEC plate 718, or another TEC plate.
Jaw member 720 is configured in much the same manner and includes similar elements for directing heat Q proximately. More particularly, and with specific reference to jaw member 720, the jaw member 720 includes lower electrically insulating portions 721a and 721b joined at edges 723a, 723b to contact an electrically conductive seal plate 722. TEC plate 728 is disposed within jaw member 720 on the opposite side 724′ of tissue engaging surface 724 of the electrically conductive sealing plate 722. A thermally conductive, electrically insulating material 786 is disposed between the sealing plate 722 and the TEC plate 728 on outer surfaces 724a and 724b of the sealing plate 722. The plate 728 includes first and second sides 762 and 762′, respectively. Side 762 abuts the opposite end 724′ of sealing plate 722. A series of electrical leads 767a, 767b, and 767c are connected to the first side 762 while a series of electrical leads 769a, 769b and 769c are connected to the second side 762′.
The thermally conductive, electrically insulating materials 784, 786 may be made of a cool polymer as described previously which prevents electrical continuity between the DC power supply 756 and an AC power supply from the previously discussed source of electrosurgical energy.
It is envisioned that first electrical potential 758 may be selectively transmitted through leads 767a, 767b and 767c and second electrical potential 759 may be selectively transmitted through leads 769a, 769b, and 796c such that different electrical potentials are created on opposite sides of the plate 728. As can be appreciated, heat Q′ in this instance may be directed proximally for absorption by a second heat sink, e.g., cool polymer, a fluid through one or more ducts 856 disposed in contact with TEC plate 728, or another TEC plate. As can be appreciated, the two jaw members 710, 720 cooperate to remove excess heat from the tissue to reduce collateral tissue effects during sealing.
Similarly, a heat sink 828 is disposed in direct contact with a second surface 742 of thermoelectric cooling plate 728. A coolant or cooling line 852 is disposed through or embedded within heat sink 828. The coolant line 852 has a coolant supply end 852a and a coolant return end 852b projecting from a proximal end of the heat sink 828.
Similarly, heat sink 828 is disposed in direct contact with the second surface 742 of thermoelectric cooling plate 728. The coolant line 852 is disposed through or embedded within heat sink 828. The coolant line 852 has a coolant supply end (not shown) and a coolant return end (not shown) projecting from a proximal end 840 of the heat sink 828. The coolant line 852 may form a U-bend 852c proximate to a distal end 844 of heat sink 828 in an analogous manner as shown with respect to U-bend 850c of coolant line 850 in heat sink 818.
In the foregoing embodiment, it is particularly suitable for the coolant lines 850 and 852 to contain an active cooling fluid (e.g., a thermally conductive, non-electrically conductive cooling liquid or a gas, e.g., air). In particular, the cooling fluid may include a liquid coolant such as water or a non-conductive fluid such as a medicinal or biocompatible fluid. However, a gas such as, but not limited to, air, nitrogen or carbon dioxide (preferably at ambient or above ambient pressure conditions) may be applied under forced flow conditions. Alternatively, coolant lines 850 and 852 may also be filled with a stagnant substance such as a below ambient temperature gas (including air, nitrogen or carbon dioxide), or a liquid or solid or frozen substance such as water ice or dry ice (solid carbon dioxide).
Coolant applied to coolant supply lines 850 and 852 removes the heat Q generated during the tissue sealing process. As discussed in more detail below with respect to
At least one of the jaw members 910 and 920 includes a cooling line disposed therethrough or embedded therein. More particularly, a coolant or cooling line 950 may be disposed or embedded within upper electrode jaw member 910. The coolant line 950 has a coolant supply end 950a and a coolant return end 950b projecting from a proximal end 938 of the upper jaw member 910. The coolant line 950 may form a U-bend 850c proximate to a distal end 942 of upper jaw member 910.
Similarly, a coolant or cooling line 952 may be disposed or embedded within lower electrode jaw member 920. The coolant line 952 has a coolant supply end 952a and a coolant return end 952b projecting from a proximal end 940 of the lower jaw member 920. The coolant line 952 may form a U-bend 952c proximate to a distal end 944 of lower jaw member 920.
The coolant lines 950 and 952 may be configured to receive a coolant to transfer heat from jaw members 910 and/or 920. In a similar manner to the previous embodiment described above, it is particularly suitable for the coolant received by the coolant lines 950 and 952 to be an active cooling fluid (preferably, a non-electrically conductive cooling liquid or a gas, e.g., air).
Coolant applied to coolant supply lines 950 and 952 removes the heat Q generated during the tissue sealing process. As discussed in more detail below with respect to
With respect to this particular embodiment and compared to the embodiments of
Those skilled in the art will recognize that the coolant loops 850 and 852, and 950 and 952 (see
More particularly,
Each shaft 12a′ and 12b′ includes a handle 17a′ and 17b′ disposed at the proximal end 16a′ and 16b′ thereof which each define a finger hole 18a′ and 18b′, respectively, therethrough for receiving a finger of the user. As can be appreciated, finger holes 18a′ and 18b′ facilitate movement of the shafts 12a′ and 12b′ relative to one another which, in turn, pivot the jaw members 110′ and 120′ from the open position wherein the jaw members 110′ and 120′ are disposed in spaced relation relative to one another for manipulating tissue to a clamping or closed position wherein the jaw members 110′ and 120′ cooperate to grasp tissue therebetween.
One of the shafts, e.g., 12b′, includes a proximal shaft-connector/flange 19′ which is designed to connect the forceps 10′ to a source of RF energy (not shown) via an electrosurgical cable 310 and plug 300. Although the details relating to the inner-working electrical connections and various components of forceps 10′ are disclosed in commonly-owned U.S. patent application Ser. No. 10/369,894 which is incorporated in its entirety by reference herein, it is disclosed herein that cooling line 1150 or 1190 and electrical cable 754 extends from the upper and lower jaw members 110′ and 120′ through the shaft 12b′ to the proximal shaft/connector flange 19′ which interfaces with electrosurgical cable 310. The cooling line 1150 or 1190 emerges from the flange 19′ at a port 1230 proximate the power cord 310. Typically, the cooling line 1150 or 1190 is coiled around the electrosurgical cable 310 to a convenient point at which it is directed to the ultimate heat sink 1250. The electrical cable 754 emerges at the port 1230 from which it extends to connect to DC power supply 756.
From the foregoing and with reference to the various figure drawings, those skilled in the art will appreciate that certain modifications can also be made to the present disclosure without departing from the scope of the same. For example, although it is preferable that jaw members 110 and 120 meet in parallel opposition, and, therefore, meet on the same plane, in some cases it may be preferable to slightly bias the jaw members 110 and 120 to meet each other at the distal end such that additional closure force on the handles is required to deflect the electrodes in the same plane. It is envisioned that this could improve seal quality and/or consistency. Alternatively, the jaws members 110 and 120 may be configured to close in a heel-based manner or in an independently floating (with respect to parallel) fashion.
It is envisioned that while the jaw members 710, 710′, 910, 910′ and 720, 720′, 920, 920′ are configured for dissipating heat generated by electrosurgical RF power, the cooling members disclosed herein (i.e., thermoelectric plates 718 and 728, corresponding heat sinks 818 and 828 and the cooling lines 850, 852, 950, 952; and the cooling loops 340, 1150 and 1190 for cooling the insulating housing 314) may be adapted as well to other heating modalities. Such other heating modalities include, but are not limited to, ultrasonic, capacitive or thermoelectric heating power sources.
While various embodiments of the disclosure have been described, it is not intended that the disclosure be limited thereto, as it is intended that the disclosure be as broad in scope as the art will allow and that the specification be read likewise. Therefore, the above descriptions should not be construed as limiting, but merely as exemplifications of preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.
The present application is a continuation-in-part (CIP) of PCT Application Serial No. PCT/US04/13273 filed on Apr. 29, 2004 entitled “ELECTROSURGICAL INSTRUMENT WHICH REDUCES THERMAL DAMAGE TO ADJACENT TISSUE” which claims the benefit of priority to U.S. Provisional Application Ser. No. 60/467,027 filed on May 1, 2003 by Chapman et al., the entire contents of both of which are incorporated by reference herein.
Number | Name | Date | Kind |
---|---|---|---|
371664 | Brannan et al. | Oct 1887 | A |
702472 | Pignolet | Jun 1902 | A |
728883 | Downes | May 1903 | A |
1586645 | Bierman | Jun 1926 | A |
1813902 | Bovie | Jul 1931 | A |
1822330 | Ainslie | Sep 1931 | A |
1852542 | Sovatkin | Apr 1932 | A |
2002594 | Wappler et al. | May 1935 | A |
2011169 | Wappler | Aug 1935 | A |
2031682 | Wappler et al. | Feb 1936 | A |
2054149 | Wappler | Sep 1936 | A |
2176479 | Willis | Oct 1939 | A |
2279753 | Knopp | Apr 1942 | A |
2305156 | Grubel | Dec 1942 | A |
2327353 | Karle | Aug 1943 | A |
2632661 | Cristofv | Mar 1953 | A |
2668538 | Baker | Feb 1954 | A |
2796065 | Kapp | Jun 1957 | A |
3073311 | Tibbs et al. | Jan 1963 | A |
3372288 | Wigington | Mar 1968 | A |
3459187 | Pallotta | Aug 1969 | A |
3643663 | Sutter | Feb 1972 | A |
3648001 | Anderson et al. | Mar 1972 | A |
3651811 | Hildebrandt et al. | Mar 1972 | A |
3678229 | Osika | Jul 1972 | A |
3720896 | Beierlein | Mar 1973 | A |
3763726 | Hildebrand | Oct 1973 | A |
3779918 | Ikeda et al. | Dec 1973 | A |
3801766 | Morrison, Jr. | Apr 1974 | A |
3862630 | Balamuth | Jan 1975 | A |
3863339 | Reaney et al. | Feb 1975 | A |
3866610 | Kletschka | Feb 1975 | A |
3911766 | Fridolph et al. | Oct 1975 | A |
3920021 | Hiltebrandt | Nov 1975 | A |
3921641 | Hulka | Nov 1975 | A |
3938527 | Rioux et al. | Feb 1976 | A |
3952749 | Fridolph et al. | Apr 1976 | A |
3970088 | Morrison | Jul 1976 | A |
3987795 | Morrison | Oct 1976 | A |
4005714 | Hiltebrandt | Feb 1977 | A |
4016881 | Rioux et al. | Apr 1977 | A |
4041952 | Morrison, Jr. et al. | Aug 1977 | A |
4043342 | Morrison, Jr. | Aug 1977 | A |
4074718 | Morrison, Jr. | Feb 1978 | A |
4076028 | Simmons | Feb 1978 | A |
4080820 | Allen | Mar 1978 | A |
4088134 | Mazzariello | May 1978 | A |
4112950 | Pike | Sep 1978 | A |
4127222 | Adams | Nov 1978 | A |
4128099 | Bauer | Dec 1978 | A |
4165746 | Burgin | Aug 1979 | A |
4187420 | Piber | Feb 1980 | A |
4233734 | Bies | Nov 1980 | A |
4236470 | Stenson | Dec 1980 | A |
4300564 | Furihata | Nov 1981 | A |
4311145 | Esty et al. | Jan 1982 | A |
D263020 | Rau, III | Feb 1982 | S |
4370980 | Lottick | Feb 1983 | A |
4375218 | DiGeronimo | Mar 1983 | A |
4416276 | Newton et al. | Nov 1983 | A |
4418692 | Guay | Dec 1983 | A |
4443935 | Zamba et al. | Apr 1984 | A |
4452246 | Bader et al. | Jun 1984 | A |
4470786 | Sano et al. | Sep 1984 | A |
4492231 | Auth | Jan 1985 | A |
4493320 | Treat | Jan 1985 | A |
4503855 | Maslanka | Mar 1985 | A |
4506669 | Blake, III | Mar 1985 | A |
4509518 | McGarry et al. | Apr 1985 | A |
4552143 | Lottick | Nov 1985 | A |
4574804 | Kurwa | Mar 1986 | A |
4597379 | Kihn et al. | Jul 1986 | A |
4600007 | Lahodny et al. | Jul 1986 | A |
4624254 | McGarry et al. | Nov 1986 | A |
4655215 | Pike | Apr 1987 | A |
4657016 | Garito et al. | Apr 1987 | A |
4662372 | Sharkany et al. | May 1987 | A |
4671274 | Sorochenko | Jun 1987 | A |
4685459 | Xoch et al. | Aug 1987 | A |
4733662 | DeSatnick et al. | Mar 1988 | A |
D295893 | Sharkany et al. | May 1988 | S |
D295894 | Sharkany et al. | May 1988 | S |
4754892 | Retief | Jul 1988 | A |
4763669 | Jaeger | Aug 1988 | A |
4827929 | Hodge | May 1989 | A |
4829313 | Taggart | May 1989 | A |
4846171 | Kauphusman et al. | Jul 1989 | A |
4887612 | Esser et al. | Dec 1989 | A |
4938761 | Ensslin | Jul 1990 | A |
4947009 | Osika et al. | Aug 1990 | A |
4985030 | Melzer et al. | Jan 1991 | A |
5007908 | Rydell | Apr 1991 | A |
5026370 | Lottick | Jun 1991 | A |
5026371 | Rydell et al. | Jun 1991 | A |
5035695 | Weber, Jr. et al. | Jul 1991 | A |
5037433 | Wilk et al. | Aug 1991 | A |
5042707 | Taheri | Aug 1991 | A |
5047046 | Bodoia | Sep 1991 | A |
5078716 | Doll | Jan 1992 | A |
5084057 | Green et al. | Jan 1992 | A |
5085659 | Rydell | Feb 1992 | A |
5099840 | Goble et al. | Mar 1992 | A |
5100430 | Avellanet et al. | Mar 1992 | A |
5108392 | Spingler | Apr 1992 | A |
5112343 | Thornton | May 1992 | A |
5116332 | Lottick | May 1992 | A |
5147357 | Rose et al. | Sep 1992 | A |
5151102 | Xamiyama et al. | Sep 1992 | A |
5151978 | Bronikowski et al. | Sep 1992 | A |
5176695 | Dulebohn | Jan 1993 | A |
5190541 | Abele et al. | Mar 1993 | A |
5196009 | Kirwan, Jr. | Mar 1993 | A |
5197964 | Parins | Mar 1993 | A |
5209747 | Knoepfler | May 1993 | A |
5211655 | Hasson | May 1993 | A |
5215101 | Jacobs et al. | Jun 1993 | A |
5217457 | Delahuerga et al. | Jun 1993 | A |
5217458 | Parins | Jun 1993 | A |
5217460 | Knoepfler | Jun 1993 | A |
5244462 | Delahuerga et al. | Sep 1993 | A |
5250047 | Rydell | Oct 1993 | A |
5250063 | Abidin et al. | Oct 1993 | A |
5258001 | Corman | Nov 1993 | A |
5258006 | Rydell et al. | Nov 1993 | A |
5261918 | Phillips et al. | Nov 1993 | A |
5275615 | Rose | Jan 1994 | A |
5277201 | Stern | Jan 1994 | A |
5282799 | Rydell | Feb 1994 | A |
5282800 | Foshee et al. | Feb 1994 | A |
5282826 | Quadri | Feb 1994 | A |
5290286 | Parins | Mar 1994 | A |
5300082 | Sharpe et al. | Apr 1994 | A |
5304203 | El-Mallawany et al. | Apr 1994 | A |
5308353 | Beurrier | May 1994 | A |
5308357 | Lichtman | May 1994 | A |
5313027 | Inoue et al. | May 1994 | A |
5314445 | Degwitz et al. | May 1994 | A |
5318589 | Lichtman | Jun 1994 | A |
5324289 | Eggers | Jun 1994 | A |
D348930 | Olson | Jul 1994 | S |
5326806 | Yokoshima et al. | Jul 1994 | A |
5330471 | Eggers | Jul 1994 | A |
5330502 | Hassler et al. | Jul 1994 | A |
5334183 | Wuchinich | Aug 1994 | A |
5334215 | Chen | Aug 1994 | A |
5336220 | Ryan et al. | Aug 1994 | A |
5336221 | Anderson | Aug 1994 | A |
5342359 | Rydell | Aug 1994 | A |
5342381 | Tidemand | Aug 1994 | A |
5342393 | Stack | Aug 1994 | A |
5344424 | Roberts et al. | Sep 1994 | A |
5350391 | Iacovelli | Sep 1994 | A |
5352222 | Rydell | Oct 1994 | A |
5354271 | Voda | Oct 1994 | A |
5356408 | Rydell | Oct 1994 | A |
5366477 | LeMarie, III et al. | Nov 1994 | A |
5368600 | Failla et al. | Nov 1994 | A |
5374277 | Hassler | Dec 1994 | A |
5376089 | Smith | Dec 1994 | A |
5383875 | Bays et al. | Jan 1995 | A |
5383897 | Wholey | Jan 1995 | A |
5389098 | Tsuruta et al. | Feb 1995 | A |
5389103 | Melzer et al. | Feb 1995 | A |
5389104 | Hahnen et al. | Feb 1995 | A |
5391166 | Eggers | Feb 1995 | A |
5391183 | Janzen et al. | Feb 1995 | A |
5396900 | Slater et al. | Mar 1995 | A |
5403312 | Yates et al. | Apr 1995 | A |
5403342 | Tovey et al. | Apr 1995 | A |
5405344 | Williamson et al. | Apr 1995 | A |
5409763 | Serizawa et al. | Apr 1995 | A |
5411519 | Tovey et al. | May 1995 | A |
5411520 | Nash et al. | May 1995 | A |
5413571 | Katsaros et al. | May 1995 | A |
5415656 | Tihon et al. | May 1995 | A |
5415657 | Taymor-Luria | May 1995 | A |
5422567 | Matsunaga | Jun 1995 | A |
5423810 | Goble et al. | Jun 1995 | A |
5425690 | Chang | Jun 1995 | A |
5425739 | Jessen | Jun 1995 | A |
5429616 | Schaffer | Jul 1995 | A |
5431672 | Cote et al. | Jul 1995 | A |
5431674 | Basile et al. | Jul 1995 | A |
5437292 | Kipshidze et al. | Aug 1995 | A |
5438302 | Goble | Aug 1995 | A |
5439478 | Palmer | Aug 1995 | A |
5441517 | Kensey et al. | Aug 1995 | A |
5443463 | Stern et al. | Aug 1995 | A |
5443464 | Russell et al. | Aug 1995 | A |
5443480 | Jacobs et al. | Aug 1995 | A |
5445638 | Rydell et al. | Aug 1995 | A |
5445658 | Durrfeld et al. | Aug 1995 | A |
5449480 | Kuriya et al. | Sep 1995 | A |
5451224 | Goble et al. | Sep 1995 | A |
5454823 | Richardson et al. | Oct 1995 | A |
5454827 | Aust et al. | Oct 1995 | A |
5456684 | Schmidt et al. | Oct 1995 | A |
5458598 | Feinberg et al. | Oct 1995 | A |
5460629 | Shlain et al. | Oct 1995 | A |
5461765 | Linden et al. | Oct 1995 | A |
5462546 | Rydell | Oct 1995 | A |
5472442 | Klicek | Dec 1995 | A |
5472443 | Cordis et al. | Dec 1995 | A |
5478351 | Meade et al. | Dec 1995 | A |
5480406 | Nolan et al. | Jan 1996 | A |
5480409 | Riza | Jan 1996 | A |
5484436 | Eggers et al. | Jan 1996 | A |
5496312 | Klicek | Mar 1996 | A |
5496317 | Goble et al. | Mar 1996 | A |
5496347 | Hashiguchi et al. | Mar 1996 | A |
5499997 | Sharpe et al. | Mar 1996 | A |
5509922 | Aranyi et al. | Apr 1996 | A |
5514134 | Rydell et al. | May 1996 | A |
5527313 | Scott et al. | Jun 1996 | A |
5528833 | Sakuma | Jun 1996 | A |
5529067 | Larsen et al. | Jun 1996 | A |
5531744 | Nardella et al. | Jul 1996 | A |
5536251 | Evard et al. | Jul 1996 | A |
5540684 | Hassler, Jr. | Jul 1996 | A |
5540685 | Parins et al. | Jul 1996 | A |
5540706 | Aust et al. | Jul 1996 | A |
5540715 | Katsaros et al. | Jul 1996 | A |
5542945 | Fritzsch | Aug 1996 | A |
5558671 | Yates | Sep 1996 | A |
5558672 | Edwards et al. | Sep 1996 | A |
5562619 | Mirarchi et al. | Oct 1996 | A |
5562699 | Heimberger et al. | Oct 1996 | A |
5562720 | Stern et al. | Oct 1996 | A |
5564615 | Bishop et al. | Oct 1996 | A |
5569241 | Edwardds | Oct 1996 | A |
5569243 | Kortenbach et al. | Oct 1996 | A |
5571100 | Goble et al. | Nov 1996 | A |
5573424 | Poppe | Nov 1996 | A |
5573534 | Stone | Nov 1996 | A |
5573535 | Viklund | Nov 1996 | A |
5575799 | Bolanos et al. | Nov 1996 | A |
5575805 | Li | Nov 1996 | A |
5578052 | Koros et al. | Nov 1996 | A |
5579781 | Cooke | Dec 1996 | A |
5582611 | Tsukagoshi et al. | Dec 1996 | A |
5582617 | Klieman et al. | Dec 1996 | A |
5585896 | Yamazaki et al. | Dec 1996 | A |
5590570 | LeMaire, III et al. | Jan 1997 | A |
5591181 | Stone et al. | Jan 1997 | A |
5597107 | Knodel et al. | Jan 1997 | A |
5601224 | Bishop et al. | Feb 1997 | A |
5601641 | Stephens | Feb 1997 | A |
5603711 | Parins et al. | Feb 1997 | A |
5603723 | Aranyi et al. | Feb 1997 | A |
5611798 | Eggers | Mar 1997 | A |
5611808 | Hossain et al. | Mar 1997 | A |
5611813 | Lichtman | Mar 1997 | A |
5620415 | Lucey et al. | Apr 1997 | A |
5620453 | Nallakrishnan | Apr 1997 | A |
5620459 | Lichtman | Apr 1997 | A |
5624452 | Yates | Apr 1997 | A |
5626578 | Tihon | May 1997 | A |
5626609 | Zvenyatsky et al. | May 1997 | A |
5630833 | Katsaros et al. | May 1997 | A |
5637110 | Pennybacker et al. | Jun 1997 | A |
5638003 | Hall | Jun 1997 | A |
5643294 | Tovey et al. | Jul 1997 | A |
5647869 | Goble et al. | Jul 1997 | A |
5647871 | Levine et al. | Jul 1997 | A |
5649959 | Hannam et al. | Jul 1997 | A |
5655650 | Naitou | Aug 1997 | A |
5658281 | Heard | Aug 1997 | A |
D384413 | Zlock et al. | Sep 1997 | S |
5662667 | Knodel | Sep 1997 | A |
5665100 | Yoon | Sep 1997 | A |
5667526 | Levin | Sep 1997 | A |
5674220 | Fox et al. | Oct 1997 | A |
5674229 | Tovey et al. | Oct 1997 | A |
5681282 | Eggers et al. | Oct 1997 | A |
5688270 | Yates et al. | Nov 1997 | A |
5690652 | Wurster et al. | Nov 1997 | A |
5690653 | Richardson et al. | Nov 1997 | A |
5693051 | Schulze et al. | Dec 1997 | A |
5693920 | Maeda | Dec 1997 | A |
5695522 | LeMaire, III et al. | Dec 1997 | A |
5700261 | Brinkerhoff | Dec 1997 | A |
5700270 | Peyser et al. | Dec 1997 | A |
5702390 | Austin et al. | Dec 1997 | A |
5707369 | Vaitekunas et al. | Jan 1998 | A |
5709680 | Yates et al. | Jan 1998 | A |
5716366 | Yates | Feb 1998 | A |
5720744 | Eggleston et al. | Feb 1998 | A |
5722421 | Francese et al. | Mar 1998 | A |
5725536 | Oberlin et al. | Mar 1998 | A |
5727428 | LeMaire, III et al. | Mar 1998 | A |
5735848 | Yates et al. | Apr 1998 | A |
5743906 | Parins et al. | Apr 1998 | A |
5752973 | Kieturakis | May 1998 | A |
5755717 | Yates et al. | May 1998 | A |
5759188 | Yoon | Jun 1998 | A |
5766130 | Selmonosky | Jun 1998 | A |
5766166 | Hooven | Jun 1998 | A |
5766170 | Eggers | Jun 1998 | A |
5766196 | Griffiths | Jun 1998 | A |
5769849 | Eggers | Jun 1998 | A |
5772655 | Bauer et al. | Jun 1998 | A |
5772670 | Brosa | Jun 1998 | A |
5776128 | Eggers | Jul 1998 | A |
5776130 | Buysse et al. | Jul 1998 | A |
5779646 | Koblish et al. | Jul 1998 | A |
5779701 | McBrayer et al. | Jul 1998 | A |
H1745 | Paraschac | Aug 1998 | H |
5792137 | Carr et al. | Aug 1998 | A |
5792165 | Klieman et al. | Aug 1998 | A |
5792177 | Kaseda | Aug 1998 | A |
5797537 | Oberlin et al. | Aug 1998 | A |
5797927 | Yoon | Aug 1998 | A |
5797938 | Paraschac et al. | Aug 1998 | A |
5797941 | Schulze et al. | Aug 1998 | A |
5797958 | Yoon | Aug 1998 | A |
5800449 | Wales | Sep 1998 | A |
5807393 | Williamson, IV et al. | Sep 1998 | A |
5810764 | Eggers et al. | Sep 1998 | A |
5810805 | Sutcu et al. | Sep 1998 | A |
5810808 | Eggers | Sep 1998 | A |
5810811 | Yates et al. | Sep 1998 | A |
5810877 | Roth et al. | Sep 1998 | A |
5814043 | Shapeton | Sep 1998 | A |
5814054 | Kortenbach et al. | Sep 1998 | A |
5817093 | Williamson, IV et al. | Oct 1998 | A |
5817119 | Klieman et al. | Oct 1998 | A |
5820630 | Lind | Oct 1998 | A |
5824978 | Karasik et al. | Oct 1998 | A |
5827271 | Buysse et al. | Oct 1998 | A |
5827279 | Hughett et al. | Oct 1998 | A |
5827281 | Levin | Oct 1998 | A |
5827323 | Klieman et al. | Oct 1998 | A |
5827548 | Lavallee et al. | Oct 1998 | A |
5833690 | Yates et al. | Nov 1998 | A |
5843080 | Fleenor et al. | Dec 1998 | A |
5849022 | Sakashita et al. | Dec 1998 | A |
5853412 | Mayenberger | Dec 1998 | A |
5859527 | Cook | Jan 1999 | A |
5860976 | Billings et al. | Jan 1999 | A |
5876401 | Schulze et al. | Mar 1999 | A |
5876412 | Piraka | Mar 1999 | A |
5882567 | Cavallaro et al. | Mar 1999 | A |
5891141 | Rydell | Apr 1999 | A |
5891142 | Eggers et al. | Apr 1999 | A |
5893863 | Yoon | Apr 1999 | A |
5893875 | O'Connor et al. | Apr 1999 | A |
5893877 | Gampp, Jr. et al. | Apr 1999 | A |
5897563 | Yoon et al. | Apr 1999 | A |
5902301 | Olig | May 1999 | A |
5906630 | Anderhub et al. | May 1999 | A |
5908420 | Parins et al. | Jun 1999 | A |
5908432 | Pan | Jun 1999 | A |
5911719 | Eggers | Jun 1999 | A |
5913874 | Berns et al. | Jun 1999 | A |
5921916 | Aeikens et al. | Jul 1999 | A |
5921984 | Sutcu et al. | Jul 1999 | A |
5925043 | Kumar et al. | Jul 1999 | A |
5928136 | Barry | Jul 1999 | A |
5935126 | Riza | Aug 1999 | A |
5941869 | Patterson et al. | Aug 1999 | A |
5944718 | Dafforn et al. | Aug 1999 | A |
5951546 | Lorentzen | Sep 1999 | A |
5951549 | Richardson et al. | Sep 1999 | A |
5954720 | Wilson et al. | Sep 1999 | A |
5954731 | Yoon | Sep 1999 | A |
5954733 | Yoon | Sep 1999 | A |
5957923 | Hahnen et al. | Sep 1999 | A |
5957937 | Yoon | Sep 1999 | A |
5960544 | Beyers | Oct 1999 | A |
5964758 | Dresden | Oct 1999 | A |
5976132 | Morris | Nov 1999 | A |
5984932 | Yoon | Nov 1999 | A |
5984938 | Yoon | Nov 1999 | A |
5989277 | LeMaire, III et al. | Nov 1999 | A |
5993466 | Yoon | Nov 1999 | A |
5993467 | Yoon | Nov 1999 | A |
5997565 | Inoue | Dec 1999 | A |
6004332 | Yoon et al. | Dec 1999 | A |
6004335 | Vaitekunas et al. | Dec 1999 | A |
6010516 | Hulka et al. | Jan 2000 | A |
6017358 | Yoon et al. | Jan 2000 | A |
6021693 | Feng-Sing | Feb 2000 | A |
6024741 | Williamson et al. | Feb 2000 | A |
6024743 | Edwards | Feb 2000 | A |
6024744 | Kese et al. | Feb 2000 | A |
6027522 | Palmer | Feb 2000 | A |
6030384 | Nezhat | Feb 2000 | A |
6033399 | Gines | Mar 2000 | A |
6039733 | Buysse et al. | Mar 2000 | A |
6041679 | Slater et al. | Mar 2000 | A |
6050996 | Schmaltz et al. | Apr 2000 | A |
6053914 | Eggers et al. | Apr 2000 | A |
6053933 | Balazs et al. | Apr 2000 | A |
D424694 | Tetzlaff et al. | May 2000 | S |
D425201 | Tetzlaff et al. | May 2000 | S |
6059782 | Novak et al. | May 2000 | A |
6066139 | Ryan et al. | May 2000 | A |
6074386 | Goble et al. | Jun 2000 | A |
6077287 | Taylor et al. | Jun 2000 | A |
6080180 | Yoon et al. | Jun 2000 | A |
RE36795 | Rydell | Jul 2000 | E |
6083223 | Baker | Jul 2000 | A |
6086586 | Hooven | Jul 2000 | A |
6086601 | Yoon | Jul 2000 | A |
6090107 | Borgmeier et al. | Jul 2000 | A |
6096037 | Mulier et al. | Aug 2000 | A |
6099550 | Yoon | Aug 2000 | A |
6102909 | Chen et al. | Aug 2000 | A |
6106542 | Toybin et al. | Aug 2000 | A |
6110171 | Rydell | Aug 2000 | A |
6113596 | Hooven et al. | Sep 2000 | A |
6113598 | Baker | Sep 2000 | A |
6117158 | Measamer et al. | Sep 2000 | A |
6122549 | Sharkey et al. | Sep 2000 | A |
6123701 | Nezhat | Sep 2000 | A |
H1904 | Yates et al. | Oct 2000 | H |
6126658 | Baker | Oct 2000 | A |
6126665 | Yoon | Oct 2000 | A |
6139563 | Cosgrove, III et al. | Oct 2000 | A |
6143005 | Yoon et al. | Nov 2000 | A |
6152923 | Ryan | Nov 2000 | A |
6162220 | Nezhat | Dec 2000 | A |
6171316 | Kovac et al. | Jan 2001 | B1 |
6174309 | Wrublewski et al. | Jan 2001 | B1 |
6178628 | Clemens et al. | Jan 2001 | B1 |
6179834 | Buysse et al. | Jan 2001 | B1 |
6179837 | Hooven | Jan 2001 | B1 |
6183467 | Shapeton et al. | Feb 2001 | B1 |
6187003 | Buysse et al. | Feb 2001 | B1 |
6190386 | Rydell | Feb 2001 | B1 |
6190400 | Vandemoer et al. | Feb 2001 | B1 |
6193718 | Kortenbach et al. | Feb 2001 | B1 |
6206876 | Levine et al. | Mar 2001 | B1 |
6206877 | Kese et al. | Mar 2001 | B1 |
6206893 | Klein et al. | Mar 2001 | B1 |
6214028 | Yoon et al. | Apr 2001 | B1 |
6217602 | Redmon | Apr 2001 | B1 |
6217615 | Sioshansi et al. | Apr 2001 | B1 |
6221039 | Durgin et al. | Apr 2001 | B1 |
6223100 | Green | Apr 2001 | B1 |
6224593 | Ryan et al. | May 2001 | B1 |
6224614 | Yoon | May 2001 | B1 |
6228080 | Gines | May 2001 | B1 |
6228083 | Lands et al. | May 2001 | B1 |
6248124 | Pedros et al. | Jun 2001 | B1 |
6248944 | Ito | Jun 2001 | B1 |
6261307 | Yoon et al. | Jul 2001 | B1 |
6267761 | Ryan | Jul 2001 | B1 |
6270497 | Sekino et al. | Aug 2001 | B1 |
6270508 | Klieman et al. | Aug 2001 | B1 |
6273887 | Yamauchi et al. | Aug 2001 | B1 |
6277117 | Tetzlaff et al. | Aug 2001 | B1 |
6280458 | Boche et al. | Aug 2001 | B1 |
6283961 | Underwood et al. | Sep 2001 | B1 |
D449886 | Tetzlaff et al. | Oct 2001 | S |
6298550 | Kirwan | Oct 2001 | B1 |
6302424 | Gisinger et al. | Oct 2001 | B1 |
6319262 | Bates et al. | Nov 2001 | B1 |
6319451 | Brune | Nov 2001 | B1 |
6322561 | Eggers et al. | Nov 2001 | B1 |
6322580 | Kanner | Nov 2001 | B1 |
6325795 | Lindemann et al. | Dec 2001 | B1 |
6334860 | Dorn | Jan 2002 | B1 |
6334861 | Chandler et al. | Jan 2002 | B1 |
6345532 | Coudray et al. | Feb 2002 | B1 |
6350264 | Hooven | Feb 2002 | B1 |
6352536 | Buysse et al. | Mar 2002 | B1 |
6358249 | Chen et al. | Mar 2002 | B1 |
6358259 | Swain et al. | Mar 2002 | B1 |
6358268 | Hunt et al. | Mar 2002 | B1 |
6364879 | Chen et al. | Apr 2002 | B1 |
D457958 | Dycus et al. | May 2002 | S |
D457959 | Tetzlaff et al. | May 2002 | S |
6391035 | Appleby et al. | May 2002 | B1 |
6398779 | Buysse et al. | Jun 2002 | B1 |
6402747 | Lindemann et al. | Jun 2002 | B1 |
6409728 | Ehr et al. | Jun 2002 | B1 |
H2037 | Yates et al. | Jul 2002 | H |
6419675 | Gallo, Sr. | Jul 2002 | B1 |
6425896 | Baltschun et al. | Jul 2002 | B1 |
6432112 | Brock et al. | Aug 2002 | B2 |
6440144 | Bacher | Aug 2002 | B1 |
6443952 | Mulier et al. | Sep 2002 | B1 |
6443970 | Schulze et al. | Sep 2002 | B1 |
6451018 | Lands et al. | Sep 2002 | B1 |
6458125 | Cosmescu | Oct 2002 | B1 |
6458128 | Schulze | Oct 2002 | B1 |
6458130 | Frazier et al. | Oct 2002 | B1 |
6461352 | Morgan et al. | Oct 2002 | B2 |
6461368 | Fogarty et al. | Oct 2002 | B2 |
6464701 | Hooven et al. | Oct 2002 | B1 |
6464702 | Schulze et al. | Oct 2002 | B2 |
6464704 | Schmaltz et al. | Oct 2002 | B2 |
6485489 | Teirstein et al. | Nov 2002 | B2 |
6494888 | Laufer et al. | Dec 2002 | B1 |
6500176 | Truckai et al. | Dec 2002 | B1 |
6506196 | Laufer | Jan 2003 | B1 |
6508815 | Strul et al. | Jan 2003 | B1 |
6511480 | Tetzlaff et al. | Jan 2003 | B1 |
6514215 | Ouchi | Feb 2003 | B1 |
6514252 | Nezhat et al. | Feb 2003 | B2 |
6517539 | Smith et al. | Feb 2003 | B1 |
6527771 | Weadock et al. | Mar 2003 | B1 |
6533784 | Truckai et al. | Mar 2003 | B2 |
6545239 | Spedale et al. | Apr 2003 | B2 |
6558385 | McClurken et al. | May 2003 | B1 |
6562037 | Paton et al. | May 2003 | B2 |
6569105 | Kortenbach et al. | May 2003 | B1 |
6582450 | Ouchi | Jun 2003 | B2 |
6585735 | Frazier et al. | Jul 2003 | B1 |
6602252 | Mollenauer | Aug 2003 | B2 |
6605790 | Yoshida | Aug 2003 | B2 |
6616658 | Ineson | Sep 2003 | B2 |
6616661 | Wellman et al. | Sep 2003 | B2 |
6620161 | Schulze et al. | Sep 2003 | B2 |
6620184 | de Laforcade et al. | Sep 2003 | B2 |
6626901 | Treat et al. | Sep 2003 | B1 |
6638287 | Danitz et al. | Oct 2003 | B2 |
6641595 | Moran et al. | Nov 2003 | B1 |
6652514 | Ellman et al. | Nov 2003 | B2 |
6656175 | Francischelli et al. | Dec 2003 | B2 |
6656177 | Truckai et al. | Dec 2003 | B2 |
6660072 | Chatterjee | Dec 2003 | B2 |
6663639 | Laufer et al. | Dec 2003 | B1 |
6663641 | Kovac et al. | Dec 2003 | B1 |
6666854 | Lange | Dec 2003 | B1 |
6669696 | Bacher et al. | Dec 2003 | B2 |
6673092 | Bacher | Jan 2004 | B1 |
6676660 | Wampler et al. | Jan 2004 | B2 |
6676676 | Danitz et al. | Jan 2004 | B2 |
6679882 | Kornerup | Jan 2004 | B1 |
6682527 | Strul | Jan 2004 | B2 |
6682528 | Frazier et al. | Jan 2004 | B2 |
6685724 | Haluck | Feb 2004 | B1 |
6689131 | McClurken | Feb 2004 | B2 |
6692445 | Roberts et al. | Feb 2004 | B2 |
6693246 | Rudolph et al. | Feb 2004 | B1 |
6695840 | Schulze | Feb 2004 | B2 |
6702810 | McClurken et al. | Mar 2004 | B2 |
6723092 | Brown et al. | Apr 2004 | B2 |
6726068 | Miller | Apr 2004 | B2 |
6726686 | Buysse et al. | Apr 2004 | B2 |
6726694 | Blatter et al. | Apr 2004 | B2 |
6733498 | Paton et al. | May 2004 | B2 |
6736813 | Yamauchi et al. | May 2004 | B2 |
6743229 | Buysse et al. | Jun 2004 | B2 |
6743230 | Lutze et al. | Jun 2004 | B2 |
6743239 | Kuehn et al. | Jun 2004 | B1 |
6743240 | Smith et al. | Jun 2004 | B2 |
6755843 | Chung et al. | Jun 2004 | B2 |
6756553 | Yamaguchi et al. | Jun 2004 | B1 |
6757977 | Dambal et al. | Jul 2004 | B2 |
D493888 | Reschke | Aug 2004 | S |
6770072 | Truckai et al. | Aug 2004 | B1 |
6773409 | Truckai et al. | Aug 2004 | B2 |
6773432 | Clayman et al. | Aug 2004 | B1 |
6773434 | Ciarrocca | Aug 2004 | B2 |
6773441 | Laufer et al. | Aug 2004 | B1 |
6775575 | Bommannan et al. | Aug 2004 | B2 |
6776780 | Mulier et al. | Aug 2004 | B2 |
6786905 | Swanson et al. | Sep 2004 | B2 |
6790217 | Schulze et al. | Sep 2004 | B2 |
6796981 | Wham et al. | Sep 2004 | B2 |
D496997 | Dycus et al. | Oct 2004 | S |
6800825 | Sasaki et al. | Oct 2004 | B1 |
6802843 | Truckai et al. | Oct 2004 | B2 |
6808525 | Latterell et al. | Oct 2004 | B2 |
D499181 | Dycus et al. | Nov 2004 | S |
6818000 | Muller et al. | Nov 2004 | B2 |
6821285 | Laufer et al. | Nov 2004 | B2 |
6835200 | Laufer et al. | Dec 2004 | B2 |
6857357 | Fujii | Feb 2005 | B2 |
6860880 | Treat et al. | Mar 2005 | B2 |
6887240 | Lands et al. | May 2005 | B1 |
6889116 | Jinno | May 2005 | B2 |
6914201 | Van Vooren et al. | Jul 2005 | B2 |
6926716 | Baker et al. | Aug 2005 | B2 |
6929644 | Truckai et al. | Aug 2005 | B2 |
6932810 | Ryan | Aug 2005 | B2 |
6932816 | Phan | Aug 2005 | B2 |
6934134 | Mori et al. | Aug 2005 | B2 |
6936061 | Sasaki | Aug 2005 | B2 |
D509297 | Wells | Sep 2005 | S |
6943311 | Miyako | Sep 2005 | B2 |
6953430 | Kodooka | Oct 2005 | B2 |
6953461 | McClurken et al. | Oct 2005 | B2 |
6958070 | Witt et al. | Oct 2005 | B2 |
6960210 | Lands et al. | Nov 2005 | B2 |
6964662 | Kidooka | Nov 2005 | B2 |
6966907 | Goble | Nov 2005 | B2 |
6972017 | Smith et al. | Dec 2005 | B2 |
6977495 | Donofrio | Dec 2005 | B2 |
6979786 | Aukland et al. | Dec 2005 | B2 |
6981628 | Wales | Jan 2006 | B2 |
6987244 | Bauer | Jan 2006 | B2 |
6994707 | Ellman et al. | Feb 2006 | B2 |
6994709 | Iida | Feb 2006 | B2 |
6997931 | Sauer et al. | Feb 2006 | B2 |
7001381 | Harano et al. | Feb 2006 | B2 |
7011657 | Truckai et al. | Mar 2006 | B2 |
7033354 | Keppel | Apr 2006 | B2 |
7033356 | Latterell et al. | Apr 2006 | B2 |
7041102 | Truckai et al. | May 2006 | B2 |
7044948 | Keppel | May 2006 | B2 |
7052489 | Griego et al. | May 2006 | B2 |
7052496 | Yamauchi | May 2006 | B2 |
7063715 | Onuki et al. | Jun 2006 | B2 |
D525361 | Hushka | Jul 2006 | S |
7070597 | Truckai et al. | Jul 2006 | B2 |
7083618 | Couture et al. | Aug 2006 | B2 |
7083619 | Truckai et al. | Aug 2006 | B2 |
7083620 | Jahns et al. | Aug 2006 | B2 |
7087051 | Bourne et al. | Aug 2006 | B2 |
7087054 | Truckai et al. | Aug 2006 | B2 |
7090673 | Dycus et al. | Aug 2006 | B2 |
7090689 | Nagase et al. | Aug 2006 | B2 |
7101371 | Dycus et al. | Sep 2006 | B2 |
7101372 | Dycus et al. | Sep 2006 | B2 |
7101373 | Dycus et al. | Sep 2006 | B2 |
7103947 | Sartor et al. | Sep 2006 | B2 |
7107124 | Green | Sep 2006 | B2 |
7112199 | Cosmescu | Sep 2006 | B2 |
D531311 | Guerra et al. | Oct 2006 | S |
7115123 | Knowlton et al. | Oct 2006 | B2 |
7118570 | Tetzlaff et al. | Oct 2006 | B2 |
7118587 | Dycus et al. | Oct 2006 | B2 |
7131860 | Sartor et al. | Nov 2006 | B2 |
7131970 | Moses et al. | Nov 2006 | B2 |
7131971 | Dycus et al. | Nov 2006 | B2 |
7135020 | Lawes et al. | Nov 2006 | B2 |
D533942 | Kerr et al. | Dec 2006 | S |
7145757 | Shea et al. | Dec 2006 | B2 |
7147638 | Chapman et al. | Dec 2006 | B2 |
7150097 | Sremcich et al. | Dec 2006 | B2 |
7150749 | Dycus et al. | Dec 2006 | B2 |
7153314 | Laufer et al. | Dec 2006 | B2 |
D535027 | James et al. | Jan 2007 | S |
7156842 | Sartor et al. | Jan 2007 | B2 |
7156846 | Dycus et al. | Jan 2007 | B2 |
7160298 | Lawes et al. | Jan 2007 | B2 |
7160299 | Baily | Jan 2007 | B2 |
7169146 | Truckai et al. | Jan 2007 | B2 |
7179255 | Lettice et al. | Feb 2007 | B2 |
7179258 | Buysse et al. | Feb 2007 | B2 |
7195631 | Dumbauld | Mar 2007 | B2 |
D541418 | Schechter et al. | Apr 2007 | S |
7207990 | Lands et al. | Apr 2007 | B2 |
D541938 | Kerr et al | May 2007 | S |
7223264 | Daniel et al. | May 2007 | B2 |
7223265 | Keppel | May 2007 | B2 |
7232440 | Dumbauld et al. | Jun 2007 | B2 |
7241288 | Braun | Jul 2007 | B2 |
7241296 | Buysse et al. | Jul 2007 | B2 |
7244257 | Podjahsky et al. | Jul 2007 | B2 |
7246734 | Shelton, IV | Jul 2007 | B2 |
7248944 | Green | Jul 2007 | B2 |
7252667 | Moses et al. | Aug 2007 | B2 |
7255697 | Dycus et al. | Aug 2007 | B2 |
7267677 | Johnson et al. | Sep 2007 | B2 |
7270660 | Ryan | Sep 2007 | B2 |
7270664 | Johnson et al. | Sep 2007 | B2 |
7276068 | Johnson et al. | Oct 2007 | B2 |
7300435 | Wham et al. | Nov 2007 | B2 |
7303557 | Wham et al. | Dec 2007 | B2 |
7311709 | Truckai et al. | Dec 2007 | B2 |
7314471 | Holman | Jan 2008 | B2 |
7318823 | Sharps et al. | Jan 2008 | B2 |
7329256 | Johnson et al. | Feb 2008 | B2 |
7329257 | Kanehira et al. | Feb 2008 | B2 |
D564662 | Moses et al. | Mar 2008 | S |
7338526 | Steinberg | Mar 2008 | B2 |
7342754 | Fitzgerald et al. | Mar 2008 | B2 |
7344268 | Jigamian | Mar 2008 | B2 |
D567943 | Moses et al. | Apr 2008 | S |
7367976 | Lawes et al. | May 2008 | B2 |
7377920 | Buysse et al. | May 2008 | B2 |
7384420 | Dycus et al. | Jun 2008 | B2 |
7384421 | Hushka | Jun 2008 | B2 |
7396336 | Orszulak et al. | Jul 2008 | B2 |
D575395 | Hushka | Aug 2008 | S |
D575401 | Hixson et al. | Aug 2008 | S |
7435249 | Buysse et al. | Oct 2008 | B2 |
7442193 | Shields et al. | Oct 2008 | B2 |
7442194 | Dumbauld et al. | Oct 2008 | B2 |
7445621 | Dumbauld et al. | Nov 2008 | B2 |
7458972 | Keppel | Dec 2008 | B2 |
7473253 | Dycus et al. | Jan 2009 | B2 |
7481810 | Dumbauld et al. | Jan 2009 | B2 |
7487780 | Hooven | Feb 2009 | B2 |
7491201 | Shields et al. | Feb 2009 | B2 |
7491202 | Odom et al. | Feb 2009 | B2 |
7500975 | Cunningham et al. | Mar 2009 | B2 |
7510556 | Nguyen et al. | Mar 2009 | B2 |
7513898 | Johnson et al. | Apr 2009 | B2 |
7540872 | Schechter et al. | Jun 2009 | B2 |
7549995 | Schultz | Jun 2009 | B2 |
7553312 | Tetzlaff et al. | Jun 2009 | B2 |
20020049442 | Roberts et al. | Apr 2002 | A1 |
20020107517 | Witt et al. | Aug 2002 | A1 |
20020188294 | Couture et al. | Dec 2002 | A1 |
20030014052 | Buysse et al. | Jan 2003 | A1 |
20030014053 | Nguyen et al. | Jan 2003 | A1 |
20030018331 | Dycus et al. | Jan 2003 | A1 |
20030018332 | Schmaltz et al. | Jan 2003 | A1 |
20030032956 | Lands et al. | Feb 2003 | A1 |
20030069570 | Witzel et al. | Apr 2003 | A1 |
20030069571 | Treat et al. | Apr 2003 | A1 |
20030078578 | Truckai et al. | Apr 2003 | A1 |
20030109875 | Tetzlaff et al. | Jun 2003 | A1 |
20030114851 | Truckai et al. | Jun 2003 | A1 |
20030139741 | Goble et al. | Jul 2003 | A1 |
20030139742 | Wampler et al. | Jul 2003 | A1 |
20030158548 | Phan et al. | Aug 2003 | A1 |
20030158549 | Swanson | Aug 2003 | A1 |
20030171747 | Kanehira et al. | Sep 2003 | A1 |
20030181910 | Dycus et al. | Sep 2003 | A1 |
20030216732 | Truckai et al. | Nov 2003 | A1 |
20030229344 | Dycus et al. | Dec 2003 | A1 |
20030236518 | Marchitto et al. | Dec 2003 | A1 |
20040030330 | Brassell et al. | Feb 2004 | A1 |
20040030332 | Knowlton et al. | Feb 2004 | A1 |
20040064151 | Mollenauer | Apr 2004 | A1 |
20040073238 | Makower | Apr 2004 | A1 |
20040073256 | Marchitto et al. | Apr 2004 | A1 |
20040078035 | Kanehira et al. | Apr 2004 | A1 |
20040082952 | Dycus et al. | Apr 2004 | A1 |
20040087943 | Dycus et al. | May 2004 | A1 |
20040115296 | Duffin | Jun 2004 | A1 |
20040116924 | Dycus et al. | Jun 2004 | A1 |
20040122423 | Dycus et al. | Jun 2004 | A1 |
20040138657 | Bourne et al. | Jul 2004 | A1 |
20040143263 | Schechter et al. | Jul 2004 | A1 |
20040147925 | Buysse et al. | Jul 2004 | A1 |
20040148035 | Barrett et al. | Jul 2004 | A1 |
20040162557 | Tetzlaff et al. | Aug 2004 | A1 |
20040176762 | Lawes et al. | Sep 2004 | A1 |
20040193153 | Sarter et al. | Sep 2004 | A1 |
20040199181 | Knodel et al. | Oct 2004 | A1 |
20040210282 | Flock et al. | Oct 2004 | A1 |
20040224590 | Rawa et al. | Nov 2004 | A1 |
20040225288 | Buysse et al. | Nov 2004 | A1 |
20040236325 | Tetzlaff et al. | Nov 2004 | A1 |
20040236326 | Schulze et al. | Nov 2004 | A1 |
20040243125 | Dycus et al. | Dec 2004 | A1 |
20040249371 | Dycus et al. | Dec 2004 | A1 |
20040249374 | Tetzlaff et al. | Dec 2004 | A1 |
20040250419 | Sremcich et al. | Dec 2004 | A1 |
20040254573 | Dycus et al. | Dec 2004 | A1 |
20040260281 | Baxter, III et al. | Dec 2004 | A1 |
20050004568 | Lawes et al. | Jan 2005 | A1 |
20050004569 | Witt et al. | Jan 2005 | A1 |
20050004570 | Chapman et al. | Jan 2005 | A1 |
20050021025 | Buysse et al. | Jan 2005 | A1 |
20050021026 | Baily | Jan 2005 | A1 |
20050021027 | Shields et al. | Jan 2005 | A1 |
20050059934 | Wenchell et al. | Mar 2005 | A1 |
20050096645 | Wellman et al. | May 2005 | A1 |
20050101951 | Wham et al. | May 2005 | A1 |
20050101952 | Lands et al. | May 2005 | A1 |
20050107784 | Moses et al. | May 2005 | A1 |
20050107785 | Dycus et al. | May 2005 | A1 |
20050113818 | Sartor et al. | May 2005 | A1 |
20050113826 | Johnson et al. | May 2005 | A1 |
20050113827 | Dumbauld et al. | May 2005 | A1 |
20050113828 | Shields et al. | May 2005 | A1 |
20050119655 | Moses et al. | Jun 2005 | A1 |
20050149017 | Dycus | Jul 2005 | A1 |
20050154387 | Moses et al. | Jul 2005 | A1 |
20050187547 | Sugi | Aug 2005 | A1 |
20050197659 | Bahney | Sep 2005 | A1 |
20050203504 | Wham et al. | Sep 2005 | A1 |
20050240179 | Buysse et al. | Oct 2005 | A1 |
20060052778 | Chapman et al. | Mar 2006 | A1 |
20060052779 | Hammill | Mar 2006 | A1 |
20060064085 | Schechter et al. | Mar 2006 | A1 |
20060064086 | Odom | Mar 2006 | A1 |
20060074417 | Cunningham et al. | Apr 2006 | A1 |
20060079888 | Mulier et al. | Apr 2006 | A1 |
20060079890 | Guerra | Apr 2006 | A1 |
20060079933 | Hushka et al. | Apr 2006 | A1 |
20060084973 | Hushka | Apr 2006 | A1 |
20060089670 | Hushka | Apr 2006 | A1 |
20060116675 | McClurken et al. | Jun 2006 | A1 |
20060129146 | Dycus et al. | Jun 2006 | A1 |
20060161150 | Keppel | Jul 2006 | A1 |
20060167450 | Johnson et al. | Jul 2006 | A1 |
20060167452 | Moses et al. | Jul 2006 | A1 |
20060173452 | Buysse et al. | Aug 2006 | A1 |
20060189980 | Johnson et al. | Aug 2006 | A1 |
20060189981 | Dycus et al. | Aug 2006 | A1 |
20060190035 | Hushka et al. | Aug 2006 | A1 |
20060217709 | Couture et al. | Sep 2006 | A1 |
20060224158 | Odom et al. | Oct 2006 | A1 |
20060229666 | Suzuki et al. | Oct 2006 | A1 |
20060253126 | Bjerken et al. | Nov 2006 | A1 |
20060259036 | Tetzlaf et al. | Nov 2006 | A1 |
20060264922 | Sartor et al. | Nov 2006 | A1 |
20060264931 | Chapman et al. | Nov 2006 | A1 |
20060271038 | Johnson et al. | Nov 2006 | A1 |
20060283093 | Petrovic et al. | Dec 2006 | A1 |
20060287641 | Perlin | Dec 2006 | A1 |
20070016182 | Lipson et al. | Jan 2007 | A1 |
20070016187 | Weinberg et al. | Jan 2007 | A1 |
20070043352 | Garrison et al. | Feb 2007 | A1 |
20070043353 | Dycus et al. | Feb 2007 | A1 |
20070055231 | Dycus et al. | Mar 2007 | A1 |
20070060919 | Isaacson et al. | Mar 2007 | A1 |
20070062017 | Dycus et al. | Mar 2007 | A1 |
20070074807 | Guerra | Apr 2007 | A1 |
20070078456 | Dumbauld et al. | Apr 2007 | A1 |
20070078458 | Dumbauld et al. | Apr 2007 | A1 |
20070078459 | Johnson et al. | Apr 2007 | A1 |
20070088356 | Moses et al. | Apr 2007 | A1 |
20070106295 | Garrison et al. | May 2007 | A1 |
20070106297 | Dumbauld et al. | May 2007 | A1 |
20070118111 | Weinberg | May 2007 | A1 |
20070118115 | Artale et al. | May 2007 | A1 |
20070142833 | Dycus et al. | Jun 2007 | A1 |
20070142834 | Dumbauld | Jun 2007 | A1 |
20070156139 | Schechter et al. | Jul 2007 | A1 |
20070156140 | Baily | Jul 2007 | A1 |
20070173811 | Couture et al. | Jul 2007 | A1 |
20070173814 | Hixson et al. | Jul 2007 | A1 |
20070179499 | Garrison | Aug 2007 | A1 |
20070198011 | Sugita | Aug 2007 | A1 |
20070203485 | Keppel | Aug 2007 | A1 |
20070213706 | Dumbauld et al. | Sep 2007 | A1 |
20070213707 | Dumbauld et al. | Sep 2007 | A1 |
20070213708 | Dumbauld et al. | Sep 2007 | A1 |
20070213712 | Buysse et al. | Sep 2007 | A1 |
20070255279 | Buysse et al. | Nov 2007 | A1 |
20070260235 | Podhajsky | Nov 2007 | A1 |
20070260238 | Guerra | Nov 2007 | A1 |
20070260241 | Dalla Betta et al. | Nov 2007 | A1 |
20070260242 | Dycus et al. | Nov 2007 | A1 |
20070265616 | Couture et al. | Nov 2007 | A1 |
20080004616 | Patrick | Jan 2008 | A1 |
20080009860 | Odom | Jan 2008 | A1 |
20080015575 | Odom et al. | Jan 2008 | A1 |
20080021450 | Couture | Jan 2008 | A1 |
20080033428 | Artale et al. | Feb 2008 | A1 |
20080039835 | Johnson et al. | Feb 2008 | A1 |
20080039836 | Odom et al. | Feb 2008 | A1 |
20080045947 | Johnson et al. | Feb 2008 | A1 |
20080058802 | Couture et al. | Mar 2008 | A1 |
20080082100 | Orton et al. | Apr 2008 | A1 |
20080091189 | Carlton | Apr 2008 | A1 |
20080114356 | Johnson et al. | May 2008 | A1 |
20080167651 | Tetzlaff et al. | Jul 2008 | A1 |
20080195093 | Couture et al. | Aug 2008 | A1 |
20080215051 | Buysse et al. | Sep 2008 | A1 |
20080243120 | Lawes et al. | Oct 2008 | A1 |
20080249527 | Couture | Oct 2008 | A1 |
20080312653 | Arts et al. | Dec 2008 | A1 |
20080319442 | Unger et al. | Dec 2008 | A1 |
20090012520 | Hixson et al. | Jan 2009 | A1 |
20090018535 | Schechter et al. | Jan 2009 | A1 |
20090024126 | Artale et al. | Jan 2009 | A1 |
20090043304 | Tetzlaff et al. | Feb 2009 | A1 |
20090048596 | Shields et al. | Feb 2009 | A1 |
20090062794 | Buysse et al. | Mar 2009 | A1 |
20090082766 | Unger et al. | Mar 2009 | A1 |
20090082767 | Unger et al. | Mar 2009 | A1 |
20090082769 | Unger et al. | Mar 2009 | A1 |
20090088738 | Guerra et al. | Apr 2009 | A1 |
20090088739 | Hushka et al. | Apr 2009 | A1 |
20090088740 | Guerra et al. | Apr 2009 | A1 |
20090088741 | Hushka et al. | Apr 2009 | A1 |
20090088744 | Townsend | Apr 2009 | A1 |
20090088745 | Hushka et al. | Apr 2009 | A1 |
20090088746 | Hushka et al. | Apr 2009 | A1 |
20090088747 | Hushka et al. | Apr 2009 | A1 |
20090088748 | Guerra et al. | Apr 2009 | A1 |
20090088749 | Hushka et al. | Apr 2009 | A1 |
20090088750 | Hushka et al. | Apr 2009 | A1 |
20090112206 | Dumbauld et al. | Apr 2009 | A1 |
20090131934 | Odom et al. | May 2009 | A1 |
20090149853 | Shields et al. | Jun 2009 | A1 |
20090149854 | Cunningham et al. | Jun 2009 | A1 |
20090171350 | Dycus et al. | Jul 2009 | A1 |
20090171353 | Johnson et al. | Jul 2009 | A1 |
20090182327 | Unger | Jul 2009 | A1 |
20090187188 | Guerra et al. | Jul 2009 | A1 |
Number | Date | Country |
---|---|---|
2104423 | Feb 1994 | CA |
2415263 | Oct 1975 | DE |
2514501 | Oct 1976 | DE |
2627679 | Jan 1977 | DE |
3612646 | Apr 1987 | DE |
4303882 | Aug 1994 | DE |
4403252 | Aug 1995 | DE |
19515914 | Jul 1996 | DE |
29616210 | Jan 1997 | DE |
19608716 | Apr 1997 | DE |
19751106 | May 1998 | DE |
19751108 | May 1999 | DE |
19738457 | Jan 2009 | DE |
0364216 | Apr 1990 | EP |
0467501 | Jan 1992 | EP |
518230 | Dec 1992 | EP |
0 541 930 | May 1993 | EP |
0572131 | Dec 1993 | EP |
584787 | Mar 1994 | EP |
0589453 | Mar 1994 | EP |
0589555 | Mar 1994 | EP |
0623316 | Nov 1994 | EP |
0624348 | Nov 1994 | EP |
0650701 | May 1995 | EP |
0694290 | Mar 1996 | EP |
0717966 | Jun 1996 | EP |
0754437 | Mar 1997 | EP |
0517243 | Sep 1997 | EP |
853922 | Jul 1998 | EP |
0887046 | Jan 1999 | EP |
0923907 | Jun 1999 | EP |
1034747 | Sep 2000 | EP |
1034748 | Sep 2000 | EP |
1025807 | Oct 2000 | EP |
1034746 | Oct 2000 | EP |
1050278 | Nov 2000 | EP |
1053719 | Nov 2000 | EP |
1053720 | Nov 2000 | EP |
1055399 | Nov 2000 | EP |
1055400 | Nov 2000 | EP |
1080694 | Mar 2001 | EP |
1082944 | Mar 2001 | EP |
1159926 | Dec 2001 | EP |
1177771 | Feb 2002 | EP |
1301135 | Apr 2003 | EP |
1472984 | Nov 2004 | EP |
0774232 | Jan 2005 | EP |
1527747 | May 2005 | EP |
1530952 | May 2005 | EP |
1535581 | Jun 2005 | EP |
1609430 | Dec 2005 | EP |
1632192 | Mar 2006 | EP |
1642543 | Apr 2006 | EP |
1645238 | Apr 2006 | EP |
1645240 | Apr 2006 | EP |
1649821 | Apr 2006 | EP |
1707143 | Oct 2006 | EP |
1769765 | Apr 2007 | EP |
1769766 | Apr 2007 | EP |
1929970 | Jun 2008 | EP |
1683496 | Dec 2008 | EP |
623316 | May 1949 | GB |
1490585 | Nov 1977 | GB |
2214430 | Jun 1989 | GB |
2213416 | Aug 1989 | GB |
501068 | Sep 1984 | JP |
502328 | Mar 1992 | JP |
5-5106 | Jan 1993 | JP |
5-40112 | Feb 1993 | JP |
06343644 | Dec 1994 | JP |
07265328 | Oct 1995 | JP |
08056955 | Mar 1996 | JP |
08252263 | Oct 1996 | JP |
09010223 | Jan 1997 | JP |
11244298 | Sep 1999 | JP |
2000342599 | Dec 2000 | JP |
2000350732 | Dec 2000 | JP |
2001008944 | Jan 2001 | JP |
2001029356 | Feb 2001 | JP |
2001128990 | May 2001 | JP |
401367 | Oct 1973 | RU |
401367 | Nov 1974 | SU |
WO8900757 | Jan 1989 | WO |
WO 9204873 | Apr 1992 | WO |
WO 9206642 | Apr 1992 | WO |
WO 9321845 | Nov 1993 | WO |
WO 9408524 | Apr 1994 | WO |
WO9420025 | Sep 1994 | WO |
WO 9502369 | Jan 1995 | WO |
WO9507662 | Mar 1995 | WO |
WO 9507662 | Mar 1995 | WO |
WO9515124 | Jun 1995 | WO |
WO9605776 | Feb 1996 | WO |
WO 9613218 | Sep 1996 | WO |
WO 9700646 | Jan 1997 | WO |
WO 9700647 | Jan 1997 | WO |
WO9710764 | Mar 1997 | WO |
WO 9710764 | Mar 1997 | WO |
WO 9724073 | Jul 1997 | WO |
WO 9724993 | Jul 1997 | WO |
WO 9827880 | Jul 1998 | WO |
WO 9903407 | Jan 1999 | WO |
WO 9903408 | Jan 1999 | WO |
WO 9903409 | Jan 1999 | WO |
WO 9912488 | Mar 1999 | WO |
WO 9923933 | May 1999 | WO |
WO 9940857 | Aug 1999 | WO |
WO 9951158 | Oct 1999 | WO |
WO 9966850 | Dec 1999 | WO |
WO 0024330 | May 2000 | WO |
WO 0024331 | May 2000 | WO |
WO0024331 | May 2000 | WO |
WO 0036986 | Jun 2000 | WO |
WO 0041638 | Jul 2000 | WO |
WO0047124 | Aug 2000 | WO |
WO 0053112 | Sep 2000 | WO |
WO 0117448 | Mar 2001 | WO |
WO 0154604 | Aug 2001 | WO |
WO0207627 | Jan 2002 | WO |
WO 0207627 | Jan 2002 | WO |
WO 02067798 | Sep 2002 | WO |
WO02080783 | Oct 2002 | WO |
WO 02080783 | Oct 2002 | WO |
WO02080784 | Oct 2002 | WO |
WO 02080784 | Oct 2002 | WO |
WO 02080785 | Oct 2002 | WO |
WO02080785 | Oct 2002 | WO |
WO 02080786 | Oct 2002 | WO |
WO02080786 | Oct 2002 | WO |
WO 02080793 | Oct 2002 | WO |
WO02080793 | Oct 2002 | WO |
WO 02080794 | Oct 2002 | WO |
WO02080794 | Oct 2002 | WO |
WO 02080795 | Oct 2002 | WO |
WO 02080796 | Oct 2002 | WO |
WO02080797 | Oct 2002 | WO |
WO 02080797 | Oct 2002 | WO |
WO 02080798 | Oct 2002 | WO |
WO 02080799 | Oct 2002 | WO |
WO 02081170 | Oct 2002 | WO |
WO02081170 | Oct 2002 | WO |
WO 03061500 | Jul 2003 | WO |
WO 03090630 | Nov 2003 | WO |
WO 2004032776 | Apr 2004 | WO |
WO2004032777 | Apr 2004 | WO |
WO 2004032777 | Apr 2004 | WO |
WO 2004052221 | Jun 2004 | WO |
WO 2004073488 | Sep 2004 | WO |
WO 2004073490 | Sep 2004 | WO |
WO2004073490 | Sep 2004 | WO |
WO2004073753 | Sep 2004 | WO |
WO 2004082495 | Sep 2004 | WO |
WO 2004098383 | Nov 2004 | WO |
WO 2004103156 | Dec 2004 | WO |
WO 2005004734 | Jan 2005 | WO |
WO2005004735 | Jan 2005 | WO |
WO 2005110264 | Nov 2005 | WO |
WO 2008045348 | Apr 2008 | WO |
WO 2008045350 | Apr 2008 | WO |
Number | Date | Country | |
---|---|---|---|
20060052778 A1 | Mar 2006 | US |
Number | Date | Country | |
---|---|---|---|
60467027 | May 2003 | US |
Number | Date | Country | |
---|---|---|---|
Parent | PCT/US2004/013273 | Apr 2004 | US |
Child | 11184338 | US |