Claims
- 1. A compound of the formula (I): ##STR364## wherein W.sub.1 and W.sub.2 each independently is a hydrogen atom or a ##STR365## wherein Y is a n-C.sub.1-6 alkylene group or a n-C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.1 and R.sub.2 each independently is a hydrogen atom or a C.sub.1-6 alkyl group, and ##STR366## may form a saturated heterocyclic ring selected from the group consisting of morpholino, pyrrolidino, piperidino, homopiperidino and piperazino groups, and the saturated heterocyclic ring except the morpholino group may have at least one C.sub.1-4 alkyl group, hydroxyl group or halogen atom as a substituent;
- Z.sub.1 is a hydrogen atom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C.sub.1-- alkyl group or a methoxy group;
- Z.sub.2 is a hydrogen atom or an amino group;
- when W.sub.1 and W.sub.2 are both hydrogen atoms, Z.sub.1 is a hydroxyl group or an iodine atom and Z.sub.2 is hydrogen atom, or Z.sub.1 and Z.sub.2 are both amino groups;
- when W.sub.1 is ##STR367## and W.sub.2 is a hydrogen atom, Z.sub.1 is not a hydroxyl group; when Z.sub.1 and Z.sub.2 are both hydrogen atoms, the ##STR368## in either W.sub.1 or W.sub.2 is a morpholino group; when Z.sub.1 is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z.sub.2 is a hydrogen atom;
- when Z.sub.1 is an amino group, Z.sub.2 is a hydrogen atom or an amino group;
- when Z.sub.1 is a methyl group, a methoxy group or an amino group, Z.sub.1 is in the 5-position; when Z.sub.1 is an iodine atom, Z.sub.1 is in the 5- or 7-position; and when Z.sub.1 and Z.sub.2 are both amino groups, Z.sub.1 and Z.sub.2 are in the 5- and 7-positions;
- and the physiologically acceptable acid addition salt thereof.
- 2. The compound of claim 1 of the formula (II): ##STR369## wherein Y is a n-C.sub.1-6 alkylene group or a propylene group having a C.sub.1-4 alkyl group as a substituent; and R.sub.1 and R.sub.2 each independently is a C.sub.1-6 alkyl group, and the ##STR370## may form a saturated heterocyclic ring selected from the group consisting of morpholino, pyrrolidino, piperidino, homopiperidino and piperazino groups, and the saturated heterocyclic ring except the morpholino group may have at least one C.sub.1-4 alkyl group, hydroxyl group or chlorine atom as a substituent;
- Z.sub.1 is a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group, an amino group, a C.sub.1-3 alkyl group or a methoxy group;
- Z.sub.2 is a hydrogen atom or an amino group;
- when Z.sub.1 is a chlorine atom, a hydroxyl group, an iodine atom, a methyl group or a methoxy group, Z.sub.2 is a hydrogen atom;
- when Z.sub.1 is an amino group, Z.sub.2 is a hydrogen atom or an amino group;
- when Z.sub.1 is a methyl group, a methoxy group or an amino group, Z.sub.1 is in the 5-position; when Z.sub.1 is an iodine atom, Z.sub.1 is in the 5- or 7-position; and when Z.sub.1 and Z.sub.2 are both amino groups, Z.sub.1 and Z.sub.2 are in the 5- and 7-positions.
- 3. The compound of claim 2, wherein Y is a n-propylene group, a n-hexylene group, a 3-methylpropylene group or a 3-(2-methylpropyl)propylene group.
- 4. The compound of claim 3, wherein R.sub.1 and R.sub.2 are both C.sub.1-4 alkyl groups.
- 5. The compound of claim 3, wherein ##STR371## is a piperidino group.
- 6. The compound of claim 2, wherein Y is a n-propylene group; and ##STR372## is a 2-methylpiperidino group, a 2,6-dimethylpiperidino group, a 4-hydroxypiperidino group, a 4-chloropiperidino group, a homopiperidino group, a 4-methylpiperazino group, a pyrrolidino group or a morpholino group.
- 7. The compound of claims 4, 5 or 6, wherein Z.sub.1 is a chlorine atom in the 5-position, and Z.sub.2 is a hydrogen atom.
- 8. The compound of claims 4, 5 or 6, wherein Z.sub.1 is a hydroxyl group in the 5-position, and Z.sub.2 is a hydrogen atom.
- 9. The compound of claim 2, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is a chlorine atom in either 4-, 6- or 7-position, an amino group in the 5-position, a methoxy groups in the 5-position, a methyl group in the 5-position or an iodine atom in either 5- or 7-position; and Z.sub.2 is a hydrogen atom.
- 10. The compound of claim 2, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is a hydroxyl group in either 4-, 6- or 7-position; and Z.sub.2 is a hydrogen atom.
- 11. The compound of claim 2, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is an amino group in the 5-position; and Z.sub.2 is an amino group in the 7-position.
- 12. The compound of claim 1 of the formula (III): ##STR373## wherein Y, R.sub.1, R.sub.2, Z.sub.1 and Z.sub.2 are the same as defined in the formula (II).
- 13. The compound of claim 12, wherein Y is a n-propylene group, a n-hexylene group, a 3-methylpropylene group or a 3-(2-methylpropyl)propylene group.
- 14. The compound of claim 13, wherein R.sub.1 and R.sub.2 are both C.sub.1-4 alkyl groups.
- 15. The compound of claim 13, wherein ##STR374## is a piperidino group.
- 16. The compound of claim 12, where Y is a n-propylene group; and ##STR375## is a 2-methylpiperidino group, a 2,6-dimethylpiperidino group, a 4-hydroxypiperidino group, a 4-chloropiperidino group, a homopiperidino group, a 4-methylpiperazino group, a pyrrolidino group or a morpholino group.
- 17. The compound of claims 14, 15 and 16, wherein Z.sub.1 is a chlorine atom in the 5-positron, and Z.sub.2 is a hydrogen atom.
- 18. The compound of claims 14, 15 and 16, wherein Z.sub.1 is a hydroxyl group in the 5-position, and Z.sub.2 is a hydrogen atom.
- 19. The compound of claim 12, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is a chlorine atom in either 4-, 6- or 7-position, an amino group in the 5-position, a methoxy group in the 5-position, a methyl group in the 5-position or an iodine atom in either 5- or 7-position; and Z.sub.2 is a hydrogen atom.
- 20. The compound of claim 12, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is a hydroxyl group in either 4-, 6- or 7-position; and Z.sub.2 is a hydrogen atom.
- 21. The compound of claim 12, wherein Y is a n-propylene group; R.sub.1 and R.sub.2 are both ethyl groups; Z.sub.1 is an amino group in the 5-position; and Z.sub.2 is an amino group in the 7-position.
- 22. The compound of claim 1 of the formula (IV): ##STR376## wherein Y, R.sub.1, R.sub.2, Z.sub.1 and Z.sub.2 are the same as defined in the formula (II), and Y', R'.sub.1 and R'.sub.2 represent the same meaning as Y, R.sub.1 and R.sub.2, respectively.
- 23. The compound of claim 22, wherein Y and Y' each independently is an ethylene group, a n-propylene group, a n-hexylene group, a 3-methylpropylene group or a 3-(2-methylpropyl)propylene group; and ##STR377## groups each independently is a dimethylamino group, a diethylamino group, a di-n-propylamino group, a di-n-butylamino group, a pyrrolidino group, a piperidino group, a homopiperidino group, a 2-methylpiperidino group, a 4-methylpiperazino group or a morpholino group.
- 24. The compound of claim 22, wherein Y is a n-propylene group; ##STR378## is a diethylamino group or a piperidino group; Y' is a n-propylene group, a n-hexylene group or a 3-methylpropylene group; and ##STR379## is a dimethylamino group, a diethylamrno group, a di-n-propylamino group, a di-n-butylamino group or a piperidino group.
- 25. The compound of claim 22, wherein Y is a 3-methylpropyl group; ##STR380## is a dimethylamino group or a piperidino group; Y' a n-propylene group, a 3-methylpropylene group, or a 3-(2-methylpropyl)propylene group; and ##STR381## group(is a dimethylamino group, a diethylamino group or a piperidino group.
- 26. The compound of claim 22, wherein Y is a n-propylene group; ##STR382## is a pyrrolidino group; Y' is a n-propylene group; and ##STR383## is a homopiperidino group, a 2-methylpiperidino group or a 4-methylpiperazino group.
- 27. The compound of claim 22, wherein Y is a n-propylene group; ##STR384## is a morpholino group; Y' is a n-propylene group; and ##STR385## is a diethylamino group, a 2,6-dimethylpiperidino group, a 4-chloropiperidino group or a 4-hydroxypiperidino group.
- 28. The compound of claims 24, 25, 26 and 27, wherein Z.sub.1 is a chlorine atom in the 5-position, and Z.sub.2 is a hydrogen atom.
- 29. The compound of claims 24, 25, 26 and 27, wherein Z.sub.1 is a hydroxyl group in the 5-position, and Z.sub.2 is a hydrogen atom.
- 30. The compound of claim 22, wherein Y and Y' are both n-propylene groups; ##STR386## are both diethylamino groups; Z.sub.1 is a chlorine atom in either 4-, 6- or 7-position, a hydroxyl group in either 6- or 7-position, an amino group in the 5-position, or an iodine atom in either 5- or 7-position; and Z.sub.2 is a hydrogen atom.
- 31. The compound of claim 22, wherein Y and Y' are both n-propylene groups; ##STR387## are both diethylamino groups; Z.sub.1 is an amino group in the 5-position; and Z.sub.2 is an amino group in the 7-position.
- 32. The compound of claim 1 of the formula (V): ##STR388## wherein Y is a n-C.sub.1-6 alkylene group or a propylene group having a C.sub.1-4 alkyl group as a substituent.
- 33. The compound of claim 32, wherein Y is an ethylene group, a n-propylene group or a 3-methylpropylene group.
- 34. The compound of claim 1 of the formula (VI): ##STR389## wherein Y is the same as defined in the formula (V).
- 35. The compound of claim 34, wherein Y is an ethylene group, a n-propylene group or a 3-methylpropylene group.
- 36. The compound of claim 1 of the formula (VII): ##STR390## wherein Y and Y' each independently is a n-C.sub.1-6 alkylene group or a n-propylene group having a C.sub.1-4 alkyl group as a substituent and either ##STR391## is a morpholino group, and the remaining ##STR392## is a di-C.sub.1-6 alkylamino group or a saturated heterocyclic ring selected from the group consisting of morpholino, pyrrolidino, piperidino, homopiperidino and piperazino, and the saturated heterocyclic ring except the morpholino group, may have at least one C.sub.1-4 alkyl group, hydroxyl group or halogen atom as a substituent.
- 37. The compound of claim 36, wherein Y is an ethylene group, a n-propylene group, a hexylene group or a 3-methylpropylene group, a 3-(2-methylpropyl)propylene group.
- 38. The compound of claim 37, wherein the remaining ##STR393## is a di-C.sub.1-4 alkylamino group.
- 39. The compound of claim 36, wherein Y and Y' are both n-propylen groups; ##STR394## is a morpholino group; and ##STR395## is a diethylamino group, a 2,6-dimethylpiperidino group, a 4-chloropiperidino group or a 4-hydroxypiperidino group.
- 40. The compound of claim 36, wherein Y and Y' are both n-propylene groups; ##STR396## is a di-n-butylamino group or a piperidino group; and ##STR397## is a morpholino group.
- 41. The compound of claim 1, wherein W.sub.1 and W.sub.2 are both hydrogen atoms; Z.sub.1 is an iodine atom in the 5- or 7-position or a hydroxyl group; and Z.sub.2 is a hydrogen atom.
- 42. The compound of claim 1, wherein W.sub.1 and W.sub.2 are both hydrogen atoms; Z.sub.1 is an amino group in the 5-position; and Z.sub.2 is an amino group in the 7-position.
Priority Claims (7)
Number |
Date |
Country |
Kind |
57-40686 |
Mar 1982 |
JPX |
|
57-40687 |
Mar 1982 |
JPX |
|
57-40688 |
Mar 1982 |
JPX |
|
57-40689 |
Mar 1982 |
JPX |
|
57-40690 |
Mar 1982 |
JPX |
|
57-40691 |
Mar 1982 |
JPX |
|
57-40192 |
Mar 1982 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 475,945, filed 3/16/83 now U.S. Pat. No. 4,533,731.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4474964 |
Ibuki et al. |
Oct 1984 |
|
4533731 |
Ibuki et al. |
Aug 1985 |
|
4549023 |
Ibuki et al. |
Oct 1985 |
|
4585869 |
Ibuki et al. |
Apr 1986 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
475945 |
Mar 1983 |
|