Claims
- 1. A compound of the formula ##STR4## wherein: R is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl;
- R.sup.1 is hydrogen, halo, C.sub.1 -C.sub.4 alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy or alkylthio, cyano, trifluoromethyl, carboxamido, mono- or di(C.sub.1 -C.sub.4 alkyl)carboxamido;
- m, n and o are independently 0-5, provided that the sum of m, n and o is 2-5;
- R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sup.3 and R.sup.4 combine with the nitrogen atom to which they are attached to form 1-pyrrolidinyl, 1-piperidinyl or 1-hexamethyleneiminyl, substituted with
- phenyl, naphthyl, (phenyl or naphthyl) (C.sub.1 -C.sub.3 alkanoyl), amino, mono- or di(C.sub.1 -C.sub.4 alkyl)amino, or a group of the formula --NH--Y--R.sup.5 ;
- wherein a phenyl or naphthyl group is unsubstituted or substituted with 1-3 halo, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy groups;
- Y is carbonyl, sulfonyl, aminocarbonyl or oxycarbonyl;
- R.sup.5 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.6 -C.sub.11 bicyclo- or tricycloalkyl, (phenyl or naphthyl) (C.sub.1 -C.sub.3 alkyl), phenyl or naphthyl;
- wherein a cycloalkyl, bicyclo- or tricycloalkyl, phenyl or naphthyl group is unsubstituted or substituted with 1-3 hydroxy, halo, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy groups;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound of claim 1 wherein m+n+o is 2-4.
- 3. A compound of claim 2 wherein R is hydrogen or alkyl.
- 4. A compound of claim 3 wherein R.sup.1 is hydrogen, halo, alkyl or alkoxy.
- 5. A compound of claim 4 wherein the group formed by the combination of R.sup.3 and R.sup.4 with the nitrogen atom to which they are attached is substituted with phenyl, naphthyl, (phenyl or naphthyl) (C.sub.1 -C.sub.3 alkyl), or (phenyl or naphthyl) (C.sub.1 -C.sub.3 alkanoyl).
- 6. A compound of claim 4 wherein the group formed by the combination of R.sup.3 and R.sup.4 with the nitrogen atom to which they are attached is substituted with a group of the formula --NH--Y--R.sup.5.
- 7. The compound of claim 1 which is N-[2-(4-(3-hydroxy-1-adamantylcarbonylamino)-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide or N-[2-(4-(4-hydroxy-1-adamantylcarbonylamino)-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide or a pharmaceutically acceptable salt thereof.
- 8. The compound of claim 1 which is N-[2-(4-benzyloxycarbonylamino-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide or a pharmaceutically acceptable salt thereof.
- 9. The compound of claim 1 which is N-[2-(4-acetylamino-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide or a pharmaceutically acceptable salt thereof.
- 10. The compound of claim 1 which is N-[2-(4-(1-adamantylcarbonylamino)-1-piperidinyl)ethyl]-1-(2-propyl)-1H-indazole-3-carboxamide or a pharmaceutically acceptable salt thereof.
- 11. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1.
- 12. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 3.
- 13. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 4.
- 14. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound of claim 10.
CROSS REFERENCE
This application is a continuation-in-part of application Ser. No. 08/405,119, filed Mar. 16, 1995 now abandoned.
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Continuation in Parts (1)
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Number |
Date |
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Parent |
405119 |
Mar 1995 |
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