The present invention is concerned with an indicator for perishable products, the use of an indicator for perishable products and a method for production of an indicator for perishable products.
Perishable products comprise fluid or granular products that may spoil when exposed to an undesirable condition. Such an undesirable condition may, for instance be a temperature outside an acceptable range, such as a too high temperature or a too low temperature. Other undesirable conditions are, for instance, exposure to UV light or to IR light, a too high pressure or too low pressure, bacterial or fungal contamination or exposure to radioactivity. Perishable products are utilized across a range of industries and may comprise granular materials, such as powders or particles, or fluids, such as liquids, emulsions or colloidal dispersions. In the medical field, perishable products may comprise vaccines, medicines, e.g. insulin, blood, intravenous fluids or biological samples, such as blood samples or saliva samples. In the field of food technology perishable products may comprise dairy products, egg-based fluids or beverages, such as wines or fresh juices. In the field of chemicals perishable products may comprise various compositions. As an example, temperature control and handling of chemical initiators used in radical polymerization reactions is crucial for avoiding fire or explosions. In most cases, particular transport and storage technology is used, to safely transport the perishable product from the production location to the end-user. For example, vaccines are temperature sensitive and are handled with cold chain technology. Thereby, the vaccine is kept within an acceptable temperature range during transport and storage, to avoid spoiling.
Nevertheless, the perishable product may unintentionally be exposed to an undesired condition. For instance, cooling installations may malfunction, insufficient sterilization may occur, or human errors may arise during handling of the perishable product. Often, it is not apparent from visual observation of the perishable product that spoiling has occurred. Especially for perishable products in the medical field, such as vaccines or medicines, failing to detect spoiling may have severe or even life-threatening consequences. Therefore, it is essential to monitor and signal whether the perishable product was exposed to an undesired condition during storage and transport.
One way of monitoring conditions during storage and transport is to include an indicator in the bulk package holding a batch of containers with a perishable product. The bulk package may, for instance, be a cold storage box and the indicator a temperature indicator. Based on a visual indication by the temperature indicator, an operator can quickly determine whether the batch has been spoiled and should be discarded. In this case, however, individual containers are not monitored and therefore an end-user has no information concerning the individual container at hand.
Another solution for monitoring conditions during storage and transport is therefore to include an indicator in or on each individual container holding the perishable product. Known indicators may be attached to the outside or to the inside of the container. Indicators placed on the inside may, for instance, be attached to the lid or to the bottom of the container. The indicator is then adhered to the lid or the bottom wall of the container during the container production process and before the filling of the container with a perishable product. Disadvantageously, the production process thereby becomes more complicated and time-consuming and existing production lines must be adapted to allow for this additional production step. Alternatively, the indicator may be moulded as an integral part of the container. However, this requires moulding of a complex geometry of the container or container lid, requiring complex and error-prone moulding steps.
Alternative solutions for monitoring conditions of products are provided in the following patent applications. US2009/0266290 A1 relates to a sensing device for detecting the presence or absence of chemical species in beverages or food items. The device comprises a sensing material. The indicator is for placement in the beverages or food items by the user and floats at the surface of the product. There is no protection of the sensing material. EP0932040 is related to the use of indicator dyes that change color during pH changes, to monitor the freshness of food and beverages. Indicator dyes from the group of anthocyanins are suggested and are included in an indicator foil coated on a polymer. The indicator dye is in direct contact with the product to be monitored. US2008/296191 is directed towards a complex packaging comprising one or more integrated sensors, such as a first sensor arranged in the main body of the package. The package further comprises a display unit and a processing unit.
Consequently, there exists a clear need for a solution wherein conditions during storage and transport can reliably be monitored in each individual container with a perishable product, without the disadvantages of a complicated, error-prone and/or time-consuming container production process.
The present disclosure concerns an indicator for a perishable product according to claim 1. The present invention also concerns the use of an indicator and a method for producing an indicator, according to the claims and as further disclosed herein.
An indicator 1 according to the disclosure is schematically shown in
The shell 1a comprises the outer surface of the indicator 1. The shell 1a forms a barrier between the indicator substance(s), further defined below, of the indicator means and the perishable product. The shell 1a is preferably fluid-tight, or hermetically tight. In one embodiment, the seal forms a hermetically sealed encapsulation of the indicator means. In a preferred embodiment, there is no contact, either physically or chemically, between the indicator means and the product. The shell 1a may be non-transparent, piecewise-transparent, transparent or translucent. Preferably the shell is piecewise transparent, transparent or translucent. By piecewise transparent is meant that at least a section of the shell, such as forming one or more windows in the shell, is transparent. By the term transparent is meant that all, or nearly all, light will pass through it. By the term translucent means that some, but not all, light passes through the shell. In one embodiment, the indicator comprises a shell (1a) which is fluid-tight or hermetically sealed, and either transparent, piecewise transparent, or translucent, encapsulating the indicator means. Preferably, the indicator comprises a fluid-tight and transparent, piecewise transparent, or translucent shell (1a) encapsulating the indicator means. The shell 1a preferably comprises an inorganic polymer, g. glass, metal oxides, an organic polymer or a combination thereof. The shell 1a may comprise an organic polymer, such as selected from the group of acrylonitrile, butadiene styrene, polyamide, polycarbonate, polyester, vinyl esters, epoxy systems, polyether, polyethylene, polylactic acid, polypropylene, polyvinyl chloride, silicone and urethane, or a combination thereof. The described polymers are meant as examples for suitable polymers and hence the invention is not limited for use of only these systems. The indicator 1 may have a spherical shape, a cuboid shape, a cylindrical shape, a pyramidal shape, a conical shape, a ring shape, such as a doughnut shape, or any other suitable shape. Preferably, the indicator has a spherical, a cylindrical, or ring shape. Advantageously, the indicator may thereby easily be moved when enclosed in a container holding a perishable product, for instance by tilting or rotating the container. Thereby, the indicator is easily visible to an operator or end-user.
The indicator means is configured to visually indicate an exposure to an undesired condition. The indicator means may comprise a substance 1b. The substance 1b is configured to change color and/or opacity when exposed to an undesired condition. When the indicator means comprises a substance 1b, the shell 1a is preferably piece-wise transparent, transparent or translucent. Upon exposure to the undesired condition, the substance 1b may, for example, change from transparent and colorless to non-transparent and colored. Advantageously, a change in color and/or opacity provides a clear visual indication that the perishable product 8 was exposed to an undesired condition and may be spoiled. Advantageously, a change in color and/or opacity allows an operator or end-user to quickly verify, with one glance, that exposure to an undesired condition has occurred. Consequently, an operator or an end-user may decide to discard the perishable product 8, with minimal waste of time and effort.
The substance 1b may preferably be configured to change to a vibrant color, such as yellow, orange, red, purple, blue or green. The substance 1b may, for instance, e.g. change color from colorless or green, to red, to indicate exposure to an undesired condition. Advantageously, the indicator 1 may thereby function as a ‘traffic light’, where green indicates that the perishable product is safe for use, while red indicates that the perishable product is unsafe for use. The change of color and/or opacity may be irreversible. Alternatively, the change of color and/or opacity may be temporary. In a preferred embodiment, the change of color and/or opacity is irreversible. The substance 1b may comprise a fluid, such as a gel, a liquid, an emulsion, a colloidal dispersion, organic polymers, inorganic polymers or a combination thereof. The substance 1b may, for instance, be configured to undergo a chemical reaction when exposed to an undesired condition, to thereby change color and/or opacity. Alternatively, the substance 1b may comprise a wax, a granular material, a compact or a porous material. For instance, the substance 1b may comprise a solid substance, a frozen solvent, a wax or a polymer configured to melt when exposed to an undesired condition, such as a undesired temperature. Thereby, the substance 1b may change opacity from non-opaque to opaque. Alternatively, the indicator means may comprise several substances including at least one solid substance 1b configured to melt, wherein the melted form promotes reaction of other substances present to give rise to change in color or opacity when exposed to undesired conditions, such as undesired temperatures. The substance 1b, and any further indicator substances, may for instance be configured to undergo a chemical reaction between functional groups, such as, but not limited to, ketones, hydroxyl, phenols, thiols, aldehydes, vinyl azlactones, 2,4-dinitrophenylhydrazine, including acids, bases and pH indicators.
The indicator means may comprise nano sized and/or micron sized magnetic or non-magnetic polymer particles having chemical reactive groups as, but not limited to, e.g. amines, carboxylic, ketones, hydroxy, thiols or aldehydes, attached to the particle surface, capable of further reaction at undesired conditions with other chemical substances as e.g. phenols, 2,4-dinitrophenylhydrazine present within the indicator means, to give a color change. Use of nano sized particles may result in more transparent color systems, whilst use of micron sized particles often results in more opaque systems.
Another embodiment may comprise of reactive initiators attached to the particle surface of the indicator means, where a radical polymerization reaction with monomers present takes place under undesired conditions, e.g. at a given temperature, and where the reaction results in a visual change in color or opacity.
In one embodiment, the indicator means comprises temperature sensitive polymers that either react with other substances present to give a visual color change, change in opacity, a change in a measurable readout or a combination thereof, at undesired conditions. Examples of temperature sensitive polymers are methylcellulose, hydroxypropyl methylcellulose, chitosan, isopropylacrylamide (NIPAAm), polyvinylmethyl ether (PVME), poly(N-vinylisobutyramide) (PNVIBA), polyethyleneoxide-propyleneoxide-b-ethylene oxide (PEO-PPOPEO), Poly(N-isopropylacrylamide) (PNIPAAm), and combination thereof. One may also use pH sensitive polymers as e.g. polyvinyl sulfonic acid, polymethacrylic acid, polydiethylaminoethyl methacrylate, polydimethylaminoethyl methacrylate or a combined pH and a temperature sensitive polymer as poly(N-isopropyl acrylamide-co-butylmethacrylate-co-acrylic acid).
Preferably, the substance 1b changes color and/or opacity when exposed to the undesired condition for a minimal time duration Δt. Preferably, Δt equals the minimal period required for the perishable product 8 to become spoiled, when exposed to the undesired condition. Advantageously, when the perishable product 8 is exposed too briefly to the undesired condition to be spoiled, the indicator 1 may not change color and/or opacity. The perishable product 8 may thereby safely be used by an end-user and not go to waste.
The indicator means may comprise at least one further substance 1c (
Accordingly, each at least one further substance 1c may change color and/or opacity when exposed to an undesired condition for a different minimal or desired time duration. For instance, one substance 1b may change from colorless or green, to orange, when briefly exposed to and undesired condition. A further substance 1c may then change from colorless to red, when exposed long enough to the undesired condition such that the perishable product 8 may spoil. Alternatively, each at least one further substance 1c may change color and/or opacity when exposed to an undesired condition for a different minimal, defined or desired time duration. For instance, one substance 1b may change from colorless or a predefined color to another color when exposed to the first undesired condition during minimum required exposure time. A further substance 1c may then change from colorless or predefined color to another color when exposed long enough, or after a predefined time, or a desired time, or a required time period, to the second undesired condition. The first undesired condition may be the same, or different from the second undesired condition, e.g. the same temperature or a lower and an upper temperature or a temperature range. Hence, the indicator 1 may comprise a shell 1a, a first indicator 1b, at least one indicator 1c, and a mean for counting or measuring exposure time, or means for counting or measuring exposure time, and or means for activating the at least one indicator 1c. The means for counting or measuring exposure time, and or means for activating the at least one indicator 1c may e.g. be a physical, chemical or electronic timer, reaction or process. The indicator substance 1b may be configured to change color when exposed to a first undesired condition for a minimal time duration Δt1. The indicator 1 may also comprise at least another indicator substance 1c to change color when exposed to a second undesired condition for a minimal time duration Δt2. The indicator substance 1c may change color when exposed to the second undesired condition for a time t1=Δt.
The indicator substance 1c may be further configured to comprise at least another indicator substance 1d (not shown). The indicator 1d may change color when exposed to a second undesired condition for a time t2>Δt. The first and second undesired conditions may be the same or different, e.g. lower and upper temperature or temperature setpoints or ranges. Advantageously, the indicator thereby indicates both that an undesired condition has occurred and whether the undesired condition has persisted long enough for the perishable product 8 to be spoiled. In one embodiment, there is at least one indicator change from exposure of an undesired condition and at least one timed indicator change, e.g at least one change for indicator 1b and/or at least one change for indicator 1c. Advantageously, an operator or end-user may then decide that the perishable product 8 is still useable or may discard the perishable product 8.
Alternatively, and/or additionally, the indicator means may comprise electronic components, as schematically shown in
The light source 5 is configured to be activated and emit light when the presence of an undesired condition is detected by the sensor 2. Preferably, the light source 5 is irreversibly activated. Once an undesired condition is detected, the light source may therefore continue to emit light. When the electronic components comprise a light source 5, the shell 1a is preferably piece-wise transparent, transparent or translucent. The light source 5 may emit a colored light of a desired color, such as red, blue, green, yellow, orange, purple, or any other color or color combination. The emitted light may comprise a blinking light or a continuous light. The light source 5 may be configured to emit light when exposed to the undesired condition for a minimal time duration Δt. The light source 5 may, for instance, be configured to emit blinking light or light of a first color when exposed to the undesired condition for a time t<Δt. The light source 5 may be further configured to emit continuous light or light of a second color when exposed to the undesired condition for a time t>Δt. Advantageously, the indicator thereby indicates both that an undesired condition has occurred and whether the undesired condition has persisted long enough for the perishable product 8 to be spoiled. An operator or end-user may then decide that the perishable product 8 is still useable or discard the perishable product. Alternatively, if the electronic components comprise multiple sensors, one light source 5 may be provided for each sensor 2.
The indicator means may comprise both electronic components and a substance 1b, as schematically shown in
Alternatively, the indicator may comprise electronic components and the shell 1a may comprise a non-transparent material, schematically shown in
The indicator 1 may be placed in the chamber 7 before a perishable product 8 is placed therein (shown in
The container 6 may further comprise a lid 9, schematically shown in the longitudinal cross-section of
The indicator 1 according to the present disclosure may be used during the transport and/or storage of a perishable product 8. The indicator 1 is configured to be immersed and freely-moveable within the perishable product 8. Preferably, the indicator 1 comprises a spherical shape, a cylindrical shape or o-ring shape and a fluid-tight shell 1a. Furthermore, the container 6 according to the present disclosure may be used for the transport and/or storage of a perishable product 8. The perishable product may comprise a medical fluid, such as a vaccine, an insulin, a biological sample, blood, a medicine, or an intravenous fluid. In one embodiment, the product is a medical fluid. In one embodiment, the medical fluid is insulin. Alternatively, the perishable product 8 may comprise a food product, such as a dairy product, an egg-based product or a beverage. Use of the container 6 is shown in
Alternative containers and indicators according to the invention, for use for a medical product, are shown in
A system for a perishable product 8 may comprise an indicator 1 according to the disclosure and an external device (not shown). The indicator 1 comprises a transmitter 4, as detailed above. Optionally, the indicator 1 comprises an RFID chip. The external device is configured to receive the signal from the transmitter 4 and/or to read the RFID chip and to convert the signal to at least a visual indication. Thereto, the external device may comprise a screen, at least one light source, or combinations thereof. The light source may be at least one led. Preferably, the screen or at least one light source is irreversibly activated. Once an undesired condition is detected, the screen or light source may therefore continue to provide the visual indication. The visual indication preferably comprises a vibrant color, such as yellow, orange, red, purple, green or blue, or other colors, or any color combination thereafter. Optionally, the visual indication may be a blinking indication or a continuous indication. Advantageously, the external device thereby indicates that the indicator 1 was exposed to an undesired condition. The signal from the transmitter 4 may be encoded and the external device may be provided with a decoding key. Advantageously, the communication between the indicator and the external device can thereby be kept exclusive, such that only an operator or end-user with an approved external device can read the indicator signal. Optionally, a detected condition stored on the storage device may be transmitted by the transmitter 4 to the external device. Advantageously, a condition history of the perishable product 8 can thereby be provided to an operator or an end-user. The moment of occurrence of an undesired condition may thereby precisely established.
In one embodiment the ID is used as an RFID without an antenna. The unit thus becomes smaller. To read the content of the ID chip, the indicator must be in close contact with the reader. As an example, the indicator can have superparamagnetic properties, i.e. when decided the indicator is pulled down on a magnet. The indicator is otherwise freely movable in the perishable product. Data is read and made visible as desired.
A method for producing the indicator 1 may comprise providing indicator means and moulding the shell 1a to encapsulate the indicator means. The indicator means may comprise a substance 1b, and optionally at least one further substance 1c. Moulding the shell 1a may comprise injection moulding, extrusion moulding, blow moulding or any other suitable moulding technique. After moulding, the shell is hardened. Inserting the substance 1b and the optional at least one further substance 1c may, for instance, comprise injecting the substance 1b into the shell 1a before hardening of the shell 1a. The method may include a step of adjusting the density and buoyancy of the indicator means to the product which it is to be used in. The indicator 1 may be further configured to comprise a mean for activating the indicator at a desired time or condition—prior to the insertion into the perishable product or when the monitoring needs to start.
Alternatively or additionally, providing the indicator 1 may comprise providing electronic components, positioning the electronic components in a mould and moulding the shell 1a to enclose the electronic components. Preferably, the moulding comprises injection moulding. The electronic components may be enclosed in a protective film before positioning in the mould. Advantageously, the electronic components are thereby protected during the moulding process.
The method may further comprise providing a container 6 comprising a chamber 7, optionally, sterilizing at least one indicator 1 and/or the container 6, and inserting the at least one indicator 1 in the chamber 7. The container 6 may be filled with a perishable product 8 before the step of inserting the at least one indicator 1, during the step of inserting the at least one indicator 1, or after the step of inserting the at least one indicator 1. The container 6 may next be closed and sealed, for instance by closing and sealing the container with a lid 9 or by closing and sealing the container walls together directly, without the use of a lid.
Reagent 1: NaOH (0.1 M) and Reagent 2: Citric acid (0.033 M)+Phenolphthalein, were chilled to 0° C., and 1 ml of reagent 1 was introduced into the vial. The vial was chilled to −80° C., and the solution allowed to harden (30 min). 1-2 layers of water (each layer 1 ml) were frozen on top of reagent 1 in the same way. Finally, reagent 2 was introduced and frozen. The indicators were then stored at either −20 or −80° C. until needed. On heating, the indicator turned red in a temperature interval −0.5° C.-0° C. Re-freezing of indicator showed no color change.
Reagent 1: NaOH (0.1 M) and Reagent 2: Citric acid (0.033 M)+Phenolphthalein, were chilled to 0° C., and 1 ml of reagent 1 was introduced into the vial. The vial was chilled to −80° C., and the solution allowed to harden (30 min). 1-2 layers of a solution DI water:ethanol=40:60 (each layer 1 ml) were frozen on top of reagent 1 in the same way. Finally, reagent 2 was introduced and frozen. The indicators were then stored at either or −80° C. until needed. On heating, the indicator turned red in a temperature interval −15° C.-−14° C. Re-freezing of indicator showed no color change.
Reagent 1: Schiff reagent and Reagent 2: Glutaraldehyde aq. solution (50% vol.), were chilled to 0° C., and 1 ml of reagent 1 was introduced into the vial. The vial was chilled to −80° C., and the solution allowed to harden (30 min). 1-2 layers of DI water (each 1 ml) were frozen on top of reagent 1 in the same way. Finally, reagent 2 was introduced and frozen. The indicators were then stored at either −20 or −80° C. until needed. On heating, the indicator turned purple at a temperature interval 2° C.-4° C. Re-freezing of indicator showed no color change.
Number | Date | Country | Kind |
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20210465 | Apr 2021 | NO | national |
Filing Document | Filing Date | Country | Kind |
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PCT/NO2022/050083 | 4/8/2022 | WO |