Patent Application
20150375268
The invention relates to an individual sorting device for tablets. The invention furthermore relates to a system with such an individual sorting device and with a tableting device with a plurality of compression punches. Finally, the invention relates to a method for checking an orderly functioning of an individual sorting device for a tableting device with compression punches.
Tablets which on account of errors in the production process do not meet specific quality requirements can be discarded by way of an individual sorting device. Tablets may also be removed in a targeted manner from the production process by individual sorting for later examination.
Tablets may be produced using so-called tableting machines. Pharmaceutical rotary presses are one example of tableting machines.
A rotary press is known from DE 10 2009 020 196, for example. The rotary press has a rotor which is rotatably driven. The rotor rotates in a substantially horizontal plane. The rotor supports a multiplicity of pairs of punches. The pairs of punches are in each case composed of an upper punch and a lower punch. Raw material for tablets is filled at a predetermined point of the circumference of the rotor into the intermediate space between the upper punch and the lower punch. Once the pair of punches which has been filled in this way is moved by the rotation of the rotor in the circumferential direction of the latter, the two punches are moved together by control curves. The punches then make their way to at least one pressure roller unit. The pressure roller unit is downstream in the circumferential direction of the rotor. Using pressure, the punches in the pressure roller unit are pressed against one another. On account thereof, the material is compressed while forming the tablet. Subsequently, the punches enter a removal station which is downstream in the circumferential direction of the rotor. The punches diverge in the removal station, and the tablet is removed and discharged.
The location where the punches are pressed together using pressure is also referred to as a pressing station. A tableting machine may comprise one or a plurality of pressing stations. For example, the tablets may be precompressed in a first pressing station and the precompressed tablets may then be finally pressed in a second pressing station.
A plurality of individual pressing stations, or a plurality of groups of pressing stations for precompressing and final pressing may be arranged such that each pressing station compresses tablets independently from the other stations or groups, respectively, such that a plurality of tablets may be simultaneously produced.
The actual compressive force used in compressing a tablet provides information pertaining to the tablet weight and the reliability of compression. Moreover, it is desirable for reliably compressed tablets with weights which are as identical as possible to be produced. Individual sorting thus compares the actual compressive force with a permissible compressive-force range. Tablets which have been compressed with a compressive force which is outside the range are discarded by the individual sorting device. Here, each individual pressing station or group of pressing stations, respectively, is assigned one individual sorting device.
Discarding is performed by way of an air impulse or a slide, for example. Discarded tablets are routed into a first discharge duct. The other tablets are routed into a second discharge duct.
Usually, a compressive-force signal is infed to the individual sorting device for this purpose. The compressive-force signal emanates from a tableting machine and may be assigned to the tablet to be sorted.
In many applications it is very important to prove that individual sorting functions in an orderly manner. Testing the individual sorting device may be of interest when starting up the individual sorting device, whether in the context of the initial commissioning or in starting up for a new batch, or when starting a new product line or new stock, for example. According to the prior art, this is carried out as follows, for example:
A punch is removed and replaced by another punch. Here, using the replaced punch, tablets have been compressed with a compressive force which is outside the permissible compressive-force range. Moreover, the tablets have been compressed with an embossing which is characteristic of the replaced punch.
By means of the embossing the result of individual sorting may be readily checked for the correct functioning of the individual sorting.
However, since this method requires re-insertion of the normal punch after the test and thus opening of the tableting machine, this form of test operation cannot be considered for start-up testing of a normal operation which is subsequent thereto.
In order for the interventions in the system which are required after the test operation to be reduced, one of the present punches may also be modified only in terms of its impressed image by sticking on an embossing element. The embossing element may then be removed again after the test operation, without any major intervention in the tableting machine.
However, the modified punch normally does not lead to compressive-force signals outside the permissible compressive-force range. In order for individual sorting to be tested, the compressive-force range may be reduced such that the compressive-force signals are outside the reduced compressive-force range.
Alternatively, the modified compression punches are explicitly conveyed to the device.
The known methods for testing the correct functioning of individual sorting devices are either not integral, since they do not check the correct functioning of sorting by means of the compressive-force signal and the actually permissible compressive-force range, or are not suitable as a start-up test, since after the test operation and prior to the normal operation they require major interventions in the system.
Therefore, according to the invention an individual sorting device for sorting tablets according to claim 1 is proposed. The tablets here have been compressed by a tableting machine using compression punches. The individual sorting device is suitable for separating tablets which can be assigned an impermissible compressive-force signal from tablets which can be assigned a permissible lying compressive-force signal. Impermissible compressive-force signals are outside a permissible compressive-force range. Permissible compressive-force signals are within the permissible compressive-force range.
The individual sorting device comprises a tablet infeed, a compressive-force signal input for receiving compressive-force signals which are assignable to the infed tablets, a programmable controller unit, and a memory. The individual sorting device is characterized in that a test control program is stored in the memory. The test control program is provided for programming/parametering the controller unit for a test operation. The test operation comprises impinging, with an offset, compressive-force signals of at least one of the compression punches.
Impinging individual compressive-force signals with an offset enables that the individual sorting device identifies the tablets by means of the compressive-force signals, since impinging leads to a compressive-force signal outside the permissible range.
Furthermore, according to the invention a system with a tableting device with a plurality of compression punches and at least one individual sorting device according to the invention is proposed.
In one embodiment of the individual sorting device, or of the system, respectively, the test operation comprises storing of signals which are received and generated during the test operation. A report is compiled at the end of the test operation, using the stored signals.
The test control program here may be part of a normal operation program. The test operation may precede a normal operation. That is to say that a normal operation program for a normal operation may also be stored in the memory of the individual sorting device.
The individual sorting device may deliver the mutually separated tablets at two tablet deliveries and comprise at least one detection device. The detection device may be disposed on one of the tablet deliveries. The detection device may be suited to detecting tablets delivered there. The detection device here is connected to the controller unit, and the controller unit is configured for counting a number of detected tablets.
The execution of the normal operation program for the normal operation may be suppressed if a number of the tablets detected during the test operation do not correspond to a nominal number.
The nominal number may be determined by a number of the compression punches of the tableting machine, a number of the compression punches which are impinged with the offset compressive-force signal, and a total number of tablets sorted during the test operation.
Furthermore, according to the invention a method for checking the orderly functioning of an individual sorting device for a tableting device with compression punches is proposed. The method here comprises producing the tablets, using the tableting device, and infeeding the tablets and compressive-force signals which are assignable to the tablets to the individual sorting device. By comparing the compressive-force signals with a permissible compressive-force range, the assigned tablets are classified as permissible or impermissible. Classifying is performed depending on the result of the comparison. Impermissible tablets are discarded. Here, prior to comparing, the compressive-force signals of at least one selected pressing station are impinged with an offset. Not all compression punches are selected here. An absolute value of the offset(s) is selected such that the impinged compressive-force signals are outside the permissible compressive-force range.
In one advantageous embodiment of the method, additionally a number of tablets produced by the selected compression punches and a number of discarded tablets are determined. Then, the determined numbers are compared. Then, for example, the execution of a normal operation which is subsequent to the check may be rendered dependent on whether the determined numbers are equal.
In this or another advantageous embodiment of the method, the selected compression punches may be manipulated such that the tablets produced by means of the modified compression punches have an impressed image which is differentiable from an impressed image of the remaining produced tablets. The method then may furthermore comprise inspecting the impressed image of the discarded tablets.
An absolute value of the offset may be equal to or greater than half a compressive-force differential between an upper limit of the compressive force of the permissible compressive-force range and a lower limit of the compressive force of the permissible compressive-force range. In particular, the absolute value of the offset may be equal to or greater than the compressive-force differential.
Exemplary embodiments of the invention will be explained in more detail by means of the drawings and the following description. In the drawings:
The individual sorting device 10 comprises a tablet infeed 20, a compressive-force signal input 30 for receiving compressive-force signals which are assignable to the infed tablets, a controller unit 40, and a memory 50. The controller unit 40 is a computer, a controller, or a programmable controller unit, for example.
Tablets are infed to the individual sorting device 10 via the tablet infeed 20, and compressive-force signals which are assigned to the tablets are infed via the signal input 30.
Various programs which are stored in the memory 50 may be uploaded to the controller unit 40. Sorting based on the uploaded program is then executed in that the controller unit 40 actuates a sorting unit 60. The sorting unit 60 then sorts the tablets in a manner corresponding to the actuation and delivers said tablets at one of at least two tablet deliveries 70, 80 which are present, for example into collection containers or onto conveying devices (both not illustrated).
In this exemplary embodiment, at least two programs are stored in the memory 50. One of the programs serves for a normal operation, and one for a test operation. In both operational modes the compressive-force signals and a predefined like compressive-force range are used by the controller unit 40 for determining the respective actuation of the sorting unit 60.
However, while in the normal operation the compressive-force signals which are actually received at the compressive-force signal input 30 are compared with the compressive-force range and tablets having compressive-force signals which are outside the compressive-force range are separated from tablets having compressive-force signals which are within the compressive-force range, in the test operation compressive-force signals of selected compression punches are impinged by the controller unit with an offset and only then compared with the compressive-force range. The selected compression punches may hereby be impinged with different offsets. The offset may be a positive one. In this case, in particular, correct sorting in the event of an upper limit of the compressive force of the permissible compressive-force range being exceeded may be verified. The offset may also be a negative one. In this case, in particular, correct sorting in the event of a lower limit of the compressive force of the permissible compressive-force range being undershot may be verified.
In one exemplary embodiment, the absolute value of the offset is equal to or greater than a compressive-force differential between the upper limit of the compressive force and the lower limit of the compressive force. In this case, the total signal (the compressive-force signal impinged so as to be offset) definitely is outside the range.
In one other exemplary embodiment, the value of the offset is equal to or greater than half the compressive-force differential. Compressive-force signals actually substantially correspond to the mean value of the upper limit of the compressive force and the lower limit of the compressive force. The modest offset thus leads to a total signal which is above the upper limit of the compressive force. At the same time, the total signal is not large enough for a maximum compressive force to be exceeded. The maximum compressive force here is a limit of the compressive force which leads to an interruption of the process, for example in order to protect tooling, the machine, or humans.
In yet another exemplary embodiment, the value of the offset is determined so as to be individual for each pressing station. For example, the value of the offset may depend on a previously established mean value of compressive-force signals of the respective pressing station and one of the two limits of the compressive force.
The compressive-force signals of the selected stations are thus modified such that they represent a compressive force which is outside the permissible compressive-force range.
After a run comprising a certain number of tablets, it may be determined by means of the ratio of the number of selected compression punches to the total number of compression punches how many tablets would have to be discarded as being impermissible if post-sorting would always function in a correct manner.
Additionally, in the tableting machine which compresses the tablets, the punches in the selected compression punches in terms of their impressed image may be modified such that tablets compressed by the selected compression punches are differentiable from the tablets compressed by other compression punches. This may be made possible by sticking on a structured film, a piece of adhesive crepe tape, or a piece of adhesive transparent tape.
In this case, it is additionally possible to check whether only those tablets which have been compressed by the selected compression punches have always been discarded.
Since the modification of the punch leads to a modification of the compressive force, it is advantageous for the offset to be determined individually.
In order for this check to be automated, the individual sorting device 10 of the second exemplary embodiment additionally comprises a detection device 90. The detection device 90 may be a vision system, for example, such as a light barrier, a light sensor, or a camera system. This is illustrated in an exemplary manner in
The controller unit 40 in this exemplary embodiment integrates or counts, respectively, also the number of received compressive-force signals. The controller unit 40 in this way determines the number of infed tablets. Alternatively or additionally, a further detection device (not illustrated), with the aid of which the controller unit 40 can determine the number of infed tablets, may be disposed on the tablet infeed 20. As the test program commences, the counter for the number of infed tablets here is also set to zero.
In this case, after infeeding a predetermined number of tablets, for example 1000 or 2000 units, it is possible to automatically check whether the proportion of infed tablets which corresponds to the ratio of the number of selected compression punches to the total number of compression punches has actually be discarded.
In as far as the controller unit 40 establishes that there is no discrepancy between the number of tablets to be discarded and the number of actually discarded tablets, a normal operation may immediately succeed the test operation in which the predetermined number of tablets has been infed.
However, if by contrast the controller unit 40 establishes a discrepancy between the number of tablets to be discarded and the number of actually discarded tablets, the normal operation may be prevented.
It is also possible for the controller unit 40 in relation to each impingement with an offset to check whether a detection signal is correspondingly received from a detection device in the tablet delivery for impermissible tablets, or whether a detection signal is not corresponding received from a detection device in the tablet delivery for permissible tablets. Then, if an expected detection signal is not received, or an unexpected detection signal is received, respectively, the controller unit 40 may also check whether the correct tablets have been discarded.
Alternatively or additionally, in the tableting machine which compresses the tablets the selected compression punches in terms of their impressed image may be modified such that tablets compressed by the selected compression punches may be automatically differentiable from tablets compressed by other compression punches by means of an image recognition device. This may be made possible by sticking on a structured film, a piece of adhesive crepe tape, or a piece of adhesive transparent tape.
The image recognition system may then be disposed on one of the two tablet deliveries 70, 80. The imager recognition device may acquire the impressed image and automatically detect whether the acquired impressed image corresponds to an impressed image which the tablets delivered at this tablet delivery should have.
10 Individual sorting device
20 Tablet infeed
30 Compressive-force signal input
40 Controller unit
50 Memory
60 Sorting unit
70 Tablet delivery
80 Tablet delivery
90 Detection device
| Number | Date | Country | Kind |
|---|---|---|---|
| 10 2013 202 975.6 | Feb 2013 | DE | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2014/051727 | 1/29/2014 | WO | 00 |
