Claims
- 1. An indole compound of the formula ##STR9## wherein Ind is 5-carboxyindol-3-yl or 5-carbamoylindol-3-yl,
- A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --S--CH.sub.2 CH.sub.2 --,
- the two Y groups together are a C-C bond, one Z is Ar, and the other Z is H, and
- Ar is phenyl in the 4-position,
- or a physiologically acceptable acid addition salt thereof.
- 2. 3-[4-(4-Phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxylic acid.
- 3. 3-[4-(4-Phenyl-1,2,3,6-tetrahydropyridyl)-butyl]-indole-5-carboxamide.
- 4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
- 5. A pharmaceutical composition comprising about 0.2 to about 500 mg of a compound of claim 2 and a pharmaceutically acceptable carrier.
- 6. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier.
- 7. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
- 8. A method of treating Parkinson's disease in a patient in need of such treatment, comprising administering to the patient an effective amount of a compound of claim 1.
- 9. A method of treating hypertension, comprising administering to a mammal in need of anti-hypertensive treatment a hypotensive amount of an indole compound of the formula ##STR10## wherein Ind is indol-3-yl substituted by hydroxymethyl or --COW, or indol-3-yl substituted by hydroxymethyl or --COW, and monosubstituted or disubstituted by alkyl, Oalkyl, OH, F, Cl or Br,
- W is H, OH, Oalkyl, NH.sub.2, NHalkyl or N(alkyl).sub.2,
- A is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 SO--CH.sub.2 CH.sub.2 -- or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,
- n is 2, 3, 4 or 5,
- the two Y groups are each H or together are a C-C bond, one Z is Ar, and the other Z is H, and
- Ar is phenyl, 2-thienyl, 3-thienyl or phenyl monosubstituted or disubstituted by O-alkyl or OH, or substituted by methylenedioxy,
- wherein each of the alkyl groups has 1-4 C atoms, with the proviso that when n is 2 or 3, the hydroxymethyl or COW group is in the 4-, 5-, 6- or 7-position of the indol-3-yl radical, or a physiologically acceptable acid addition salt thereof.
- 10. A method of treating hypertension, comprising administering to a mammal in need of anti-hypertensive treatment a hypotensive amount of a compound of claim 2.
- 11. A method of treating hypertension, comprising administering to a mammal in need of anti-hypertensive treatment a hypotensive amount of a compound of claim 3.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3342632 |
Nov 1983 |
DEX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of application Ser. No. 674,635, filed Nov. 26, 1984 now abandoned.
US Referenced Citations (3)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
674635 |
Nov 1984 |
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