Claims
- 1. A compound selected from the group of compounds represented by Formula I
- 2. The compound of claim 1 wherein Ar is phenyl optionally substituted at one or two substitutents independently selected from the group consisting of halo and alkoxy, and R3 is —SO2R7, wherein R7 is alkyl.
- 3. The compound of claim 2 wherein A is —O—.
- 4. The compound of claim 3 wherein R1is alkyl or cyano.
- 5. The compound of claim 2 wherein A is —S—.
- 6. The compound of claim 5 wherein R1 is alkyl, hydroxyalkyl, or cyano.
- 7. The compound of claim 2 wherein A is —CH2—.
- 8. The compound of claim 7 wherein R1 is alkyl or cyano.
- 9. The compound of claim 1 comprising:
3-(2-Chloro-benzyl)-6-methanesulfonyl-2-methyl-1H-indole; (6-Methanesulfonyl-3-phenylsulfanyl-1H-indol-2-yl)-methanol; 3-(4-Fluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile; 3-(2,4-Difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile; 3-(4-Fluoro-benzenesulfinyl)-6-methanesulfonyl-2-methyl-1H-indole; 3-(4-Fluoro phenoxy)-6-methanesulfonyl-2-methyl-1H-indole
- 10. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable excipient.
- 11. A method of treatment of a disease in a mammal treatable by administration of a selective COX II inhibitor comprising administration to the mammal a therapeutically effective amount of a compound of claim 1.
- 12. The method of claim 11, wherein the disease is an inflammatory disease selected from myositis, synovitis, arthritis (rheumatoid arthritis and osteoarthritis), gout, back pain, dental pain, sports injuries, sprains, strains, headache, tendonitis, ankylosing, sponylitis and bursitis.
- 13. The method of claim 11, wherein the disease is dysmenorrhoea or premature labor.
- 14. The method of claim 11, wherein the disease is Alzheimer's.
- 15. A process for preparing a compound selected from the group of compounds of claim 1, which comprises:
reacting a compound of general Formula 17 wherein R2 is as defined in claim 1, and R is lower alkyl, with a compound of general Formula ArAH, to provide a compound of Formula (I): 18 wherein R2, A, and Ar are as defined in claim 1, and R is lower alkyl.
- 16. A process for preparing a compound selected from the group of compounds of claim 1, which comprises
reacting a compound of general Formula 19 wherein R2 and R3 are as defined in claim 1, with a compound of general Formula 20 wherein R1 is as defined in claim 1, to provide a compound of Formula (I): 21 wherein R1, R2, R3, and Ar are as defined in claim 1.
CROSS-REFERENCE
[0001] This application claims the benefit of priority of U.S. Provisional Patent Application Serial No. 60/325,389, filed Sep. 27, 2001, which is incorporated herein by reference in its entirety.
Provisional Applications (1)
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Number |
Date |
Country |
|
60325389 |
Sep 2001 |
US |