Claims
- 1. An indole derivative represented by the formula (I): ##STR42## wherein R.sup.1 represents C.sub.1 -C.sub.5 alkyl, C.sub.4 -C.sub.6 cycloalkylalkl, C.sub.5 -C.sub.7 cycloalkenylalkyl, C.sub.1 -C.sub.3 aralkyl, C.sub.4 -C.sub.5 trans-alkenyl, allyl, C.sub.1 -C.sub.3 furan-2-ylalkyl or C.sub.1 -C.sub.3 thiophene-2-ylalkyl;
- R.sup.2 represents hydrogen, hydroxy, C.sub.1 -C.sub.5 alkanoyloxy or C.sub.1 -C.sub.5 alkoxy;
- R.sup.3 represents hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkanoyl or benzyl;
- R.sup.4 represents hydrogen, C.sub.1 -C.sub.5 alkyl or benzyl;
- R.sup.5 and R.sup.6 cooperatively represent --S.dbd.T--U.dbd.V wherein one of S, T, U and V represents a nitrogen and the remainders represent CH with the proviso that the hydrogen may be substituted with R.sup.10 wherein R.sup.10 represents C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoyl, C.sub.1 -C.sub.5 hydroxyalkyl, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7 (CH.sub.2).sub.m CO.sub.2 R.sup.7, SO.sub.2 NR.sup.8 R.sup.9, CONR.sup.8 R.sup.9, or (CH.sub.2).sub.n NR.sup.8 R.sup.9 wherein m represents an integer of 0-3, n represents an integer of 1-3, R.sup.7 represents C.sub.1 -C.sub.5 alkyl, R.sup.8 and R.sup.9 ' the same or different, represent C.sub.1 -C.sub.5 alkyl, or C.sub.4 -C.sub.6 cycloalkylalkyl, and which R.sup.5 and R.sup.6 are bonded to carbon atoms adjacent to each other on the benzene ring to form a ring;
- and pharmaceutically acceptable acid addition salts thereof.
- 2. The compound or acid addition salts according to claim 1, wherein R.sup.1 is C.sub.4 -C.sub.6 cycloalkylalkyl.
- 3. A pharmaceutical composition comprising an effective amount of a compound according to claim 1; and a pharmaceutically acceptable carrier.
- 4. A method of immunosuppressing a patient which comprises administering to a patient in need thereof an effective immunosuppressive amount of the compound according to claim 1.
- 5. A method of treating allergies which comprises administering to a patient in need thereof an effective antiallergic amount of the compound according to claim 1.
- 6. A method of treating inflammation which comprises administering to a patient in need thereof an effective anti-inflammatory amount of the compound according to claim 1.
- 7. A method of protecting brain cells from cytotoxic damage which comprises administering to a patient in need thereof, and effective brain cell-protecting from cytotoxic damage amount of the compound according to claim 1.
Priority Claims (1)
| Number |
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| 4-259841 |
Sep 1992 |
JPX |
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Parent Case Info
This application is a continuation divisional of application Ser. No. 08/709,835, filed on Sep. 10, 1996, now U.S. Pat. No. 5,852,030, which is a continuation of application Ser. No. 08/244,198, filed on May 27, 1994, now abandoned, which is the national phase of PCT International Application No. PCT/JP93/0188 filed on Sep. 29, 1993 under 35 U.S.C. .sctn. 371. The entire contents of each of the above identified applications are hereby incorporated by reference.
US Referenced Citations (7)
Foreign Referenced Citations (4)
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Nov 1990 |
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Divisions (1)
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| Parent |
709835 |
Sep 1996 |
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Continuations (1)
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244198 |
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Patent Grant
6087369
