Claims
- 1. An indolin-2-one compound of the formula I as follows: ##STR14## wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl, or a group of the formula ##STR15## wherein A is a straight-chained or branched C.sub.2 -C.sub.4 alkylene and z is oxygen,
- R.sub.2 is hydrogen, hydroxyl, C.sub.1 -C.sub.6 alkoxy or C.sub.2 -C.sub.4 alkenyloxy,
- R.sub.3 is hydrogen
- X is hydrogen
- Y is hydrogen, or a group of the general formula ##STR16## wherein Q is hydrogen or Q and X together represent a bond, and R.sub.7 is imidazole, triazole, pyrrole, pyrazole, pyridine, thiophene, indole, indazole, or uracil or R.sub.7 is phenyl which is optionally substituted one or two times by hydroxyl, carboxyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulphinyl, C.sub.1 -C.sub.6 alkylsulphonylamido, methylenedioxy, nitro, or amino,
- with the proviso that R.sub.1 cannot be a C.sub.1 -C.sub.6 alkyl radical when X and Y are both hydrogen atoms; or
- the pharmacologically acceptable salts thereof.
- 2. The compound of claim 1, wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl radical and X and Q together represent a bond.
- 3. The compound of claim 1 wherein Q and X together represent a bond and R.sub.7 is phenyl substituted one or two times by hydroxyl, carboxyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulphinyl, C.sub.2 -C.sub.6 alkanoylamido, C.sub.1 -C.sub.6 alkylsulphonylamido, nitro or amino.
- 4. The compound of claim 1, wherein R.sub.1 is the group of the general formula ##STR17## wherein A is ethylene,
- Z is oxygen,
- R.sub.2 is hydrogen, hydroxyl, C.sub.1 -C.sub.6 alkoxy or C.sub.2 -C.sub.4 alkenyloxy.
- 5. The compound of claim 4 wherein R.sub.2 is hydroxyl.
- 6. The compound of claim 4 wherein R.sub.2 is hydrogen.
- 7. The compound as claimed in claim 1 designated 4-(2-hydroxy-3-isopropylaminopropoxy)-3-(2-hydroxybenzylidene)-indolin-2-one.
- 8. The compound as claimed in claim 1 designated 4-(2-hydroxy-3-isopropylaminopropoxy)-3-(2-hydroxy-4-methylthiobenzylidene)-indolin-2-one and the pharmacologically acceptable salts thereof.
- 9. The compound as claimed in claim 1 designated 4-{2-hydroxy-3-[2-(4-hydroxyphenoxy)ethylamino]-propoxy}-3-(2-hydroxybenzylidene)-indolin-2-one and the pharmacologically acceptable salts thereof.
- 10. The compound as claimed in claim 1 designated 4-{2-hydroxy-3-[2-(4-hydroxyphenoxy)ethylamino]-propoxy}-3-(2-carboxybenzylidene)-indolin-2-one and the pharmacologically acceptable salts thereof.
- 11. The compound as claimed in claim 1 designated 4-[2-hydroxy-3-(2-phenoxyethylamino)propoxy]-3-(pyrazol-5-yl)-methyleneindolin-2-one and the pharmacologically acceptable salts thereof.
- 12. The compound as claimed in claim 1 designated 4-{2-hydroxy-3-[2-(4-hydroxyphenoxy)ethylamino]-propoxy}-3-(2-hydroxybenzyl)-indolin-2-one and the pharmacologically acceptable salts thereof.
- 13. The compound as claimed in claim 1 designated 4-{2-hydroxy-3-[2-(4-hydroxyphenoxy)ethylamino]-propoxy}-3-(pyrazol-5-yl-methyl)-indolin-2-one and the pharmacologically acceptable salts thereof.
- 14. The compound as claimed in claim 1 designated 4-[2-hydroxy-3-(2-phenoxyethylamino)propoxy]-3-(pyrazol-5-yl-methyl)indolin-2-one and the pharmacologically acceptable salts thereof.
- 15. A pharmaceutical composition for the treatment of circulatory and cardiac diseases comprising a pharmaceutically acceptable carrier and in effective amounts, an indolin-2-one derivative compound as claimed in claim 1.
- 16. A method of treating a subject for circulatory and cardiac diseases which comprises administering to such subject an effective amount of an indolin-2-one derivative compound as claimed in claim 1.
- 17. The method as claimed in claim 13 wherein said disease is hypertension.
- 18. The method as claimed in claim 13 wherein said disease is angina pectoris.
- 19. The compound as claimed in claim 1 designated 4-[2-hydroxy-3-(2-phenoxyethylamino)-propoxy]-indolin-2-one.
- 20. The compound of claim 4 wherein X=Y=hydrogen R.sub.2 is hydrogen or hydroxy.
- 21. The compound of claim 1 wherein Y is a group of the general formula ##STR18## wherein Q is hydrogen or Q and X together represent a bond, and R.sub.7 is imidazole, triazole, pyrrole, pyrazole, pyridine, thiophene, indole, indazole, or uracil or R.sub.7 is phenyl or phenyl substituted one or two times by hydroxyl, carboxyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylsulphinyl, C.sub.1 -C.sub.6 alkylsulphonylamido, nitro, or amino.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3310891 |
Mar 1983 |
DEX |
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Parent Case Info
This application is a continuation, of application Ser. No. 592,616, filed Mar. 23, 1984 now abn.
US Referenced Citations (7)
Continuations (1)
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Number |
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592616 |
Mar 1984 |
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