Claims
- 1. A compound of formula ##STR6## or a pharmaceutically acceptable salt thereof or a regioisomeric mixture thereof wherein one of R.sup.1 and R.sup.2 is a hydrogen or a straight or branched alkyl of from 1 to 6 carbon atoms and the other of R.sup.1 and R.sup.2 is a straight or branched carboxyalkyl, azidoalkyll, amidinoalkyl, amidinothioalkyl, (2-nitroguanidino) alkyl, containing in each case from 1 to 6 carbon atoms, or is
- --(CH.sub.2).sub.2 --CO--NR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are each independently hydrogen, alkyl of from 1 to 4 carbon atoms or benzyl; and
- X and Y are each hydrogen or one of X and Y is hydrogen and the other is hydrogen or alkoxy of from 1 to 4 carbon atoms.
- 2. A compound according to claim 1, wherein one of R.sup.1 and R.sup.2 is hydrogen, methyl, ethyl, propyl or isopropyl and the other of R.sup.1 and R.sup.2 is carboxymethyl, 2-carboxyethyl or 3-carboxypropyl and X and Y are each hydrogen.
- 3. A compound according to claim 1, wherein one of R.sup.1 and R.sup.2 is methyl or ethyl and the other of R.sup.1 and R.sup.2 is carboxymethyl, 2-carboxyethyl or 3-carboxypropyl and X and Y are each hydrogen.
- 4. A compound selected from the group consisting of
- 12-(3-azidopropyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, and
- 13-(3-azidopropyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole.
- 5. A pharmaceutical composition which comprises a therapeutically effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.
- 6. A method for treating or preventing diseases of the blood vessels and heart which comprises administering a therapeutically effective amount of a pharmaceutical composition according to claim 5 to a mammal in need thereof.
- 7. A compound of the formula 12-(2-carboxyethyl)-6,7,12,13-tetrahydro-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole.
Priority Claims (1)
Number |
Date |
Country |
Kind |
39 42 296.8 |
Dec 1989 |
DEX |
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Parent Case Info
This is a continuation of Ser. No. 08/039,541, filed Mar. 29, 1993, now abandoned. It is to be noted that Ser. No. 087/039,541 is a continuation of Ser. No. 07/828,532 filed Jan. 24, 1992 and abandoned, which is a C-I-P of Ser. No. 07/632,224 filed Dec. 19, 1990, which is also abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4912107 |
Kleinschroth et al. |
Mar 1990 |
|
Non-Patent Literature Citations (1)
Entry |
Magnus et al, "Indole -2,3-Quinodimethanes, etc" Tetrahedron, 40 (14) pp. 2795-2797 (1984). |
Continuations (2)
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Number |
Date |
Country |
Parent |
39541 |
Mar 1993 |
|
Parent |
828532 |
Jan 1992 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
632224 |
Dec 1990 |
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