INDEX
- I. Background of the Invention
- II. Summary of the Invention
- III. Brief Description of the FIGS.
- IV. Detailed Description of the Invention
- A. Definitions
- B. Stimulation of CTL and HTL responses
- C. Binding Affinity of Peptide Epitopes for HLA Molecules
- D. Peptide Epitope Binding Motifs and Supermotifs
- 1. HLA-A1 supermotif
- 2. HLA-A2 supermotif
- 3. HLA-A3 supermotif
- 4. HLA-A24 supermotif
- 5. HLA-B7 supermotif
- 6. HLA-B27 supermotif
- 7. HLA-B44 supermotif
- 8. HLA-B58 supermotif
- 9. HLA-B62 supermotif
- 10. HLA-A1 motif
- 11. HLA-A2.1 motif
- 12. HLA-A3 motif
- 13. HLA-A11 motif
- 14. HLA-A24 motif
- 15. HLA-DR-1-4-7 supermotif
- 16. HLA-DR3 motifs
- E. Enhancing Population Coverage of the Vaccine
- F. Immune Response-Stimulating Peptide Epitope Analogs
- G. Computer Screening of Protein Sequences from Disease-Related Antigens for Supermotif- or Motif-Containing Epitopes
- H. Preparation of Peptide Epitopes
- I. Assays to Detect T-Cell Responses
- J. Use of Peptide Epitopes for Evaluating Immune Responses
- K. Vaccine Compositions
- 1. Minigene Vaccines
- 2. Combinations of CTL Peptides with Helper Peptides
- L. Administration of Vaccines for Therapeutic or Prophylactic Purposes
- M. Kits
- V. Examples
- VI. Claims
- VII. Abstract
I. BACKGROUND OF THE INVENTION
Acquired immunodeficiency syndrome (AIDS) caused by infection with human immunodeficiency virus-1 (HIV-1) represents a major world health problem. Estimates indicate that about 16,000 people worldwide are infected with HIV each day.
The development of anti-viral drugs has been a major advancement in reducing viral loads in HIV infected patients. Highly active retroviral therapy (HAART) has been shown to reduce viremia to nearly undetectable levels. However, current drug therapies are not practicable as a long term solution to the HIV epidemic. HAART therapy is severely limited due to poor tolerance for the drugs and the emergence of drug-resistant virus. Moreover, replication competent HIV persists in the lymphoid tissue of patients who have responded to HAART, thus serving as a reservoir of virus. Lastly, current anti-retroviral drug therapies have little impact upon the global epidemic: almost 90% of the world's HIV infected population resides within countries lacking financial resources for these drugs. Thus, a need exists for an efficacious vaccine to both prevent and treat HIV infection.
Virus-specific, human leukocyte antigen (HLA) class I-restricted cytotoxic T lymphocytes (CTL) are known to play a major role in the prevention and clearance of virus infections in vivo (Oldstone et al., Nature 321:239, 1989; Jamieson et al., J. Virol. 61:3930, 1987; Yap et al, Nature 273:238, 1978; Lukacher et al., J. Exp. Med. 160:814, 1994; McMichael et al., N. Engl. J. Med. 309:13, 1983; Sethi et al., J. Gen. Virol. 64:443, 1983; Watari et al., J. Exp. Med. 165:459, 1987; Yasukawa et al., J. Immunol. 143:2051, 1989; Tigges et al., J. Virol. 66:1622, 1993; Reddenhase et al., J. Virol. 55:263, 1985; Quinnan et al., N. Engl. J. Med. 307:6, 1982). HLA class I molecules are expressed on the surface of almost all nucleated cells. Following intracellular processing of antigens, epitopes from the antigens are presented as a complex with the HLA class I molecules on the surface of such cells. CTL recognize the peptide-HLA class I complex, which then results in the destruction of the cell bearing the HLA-peptide complex directly by the CTL and/or via the activation of non-destructive mechanisms e.g., the production of interferon, that inhibit viral replication.
While immune correlates of protective immunity against HIV infection are not well defined, there is a growing body of evidence that suggests CTL are important in controlling HIV infection. HIV-specific CTL responses can be detected early in infection and the appearance of the responses corresponds to the time in infection at which initial viremia is reduced (Pantaleo et al., Nature 370:463, 1994; Walker et al., Proc. Natl. Acad. Sci. 86:9514, 1989). In addition, HIV replication in infected lymphocytes can be inhibited by incubation with autologous CTL (see, e.g., Tsubota et al., J. Exp. Med. 169:1421, 1989). These data are supported by recent studies that indicate CTL are required for controlling viral replication in a SIV/rhesus animal model (Schmitz et al., Science 283:857, 1999), and additionally supported by studies that demonstrate that CTL exert selective pressure on HIV populations as evidenced by the eventual predominance of viruses with amino acid replacements in those regions of the virus to which CTL responses are directed (see, e.g., Borrow et al., Nature Med. 3:205-211, 1997; Price et al., Proc. Nat. Acad. Sci. 94:12890-1895, 1997; Koenig et al., Nature Med. 1:330-336, 1995; and Haas et al., J. Immunol. 157:4212-4221, 1996)
Virus-specific T helper lymphocytes are also known to be critical for maintaining effective immunity in chronic viral infections. Historically, HTL responses were viewed as primarily supporting the expansion of specific CTL and B cell populations; however, more recent data indicate that HTL may directly contribute to the control of virus replication. For example, a decline in CD4+ T cells and a corresponding loss in HTL function characterize infection with HIV (Lane et al., New Engl. J. Med. 313:79, 1985). Furthermore, studies in HIV infected patients have also shown that there is an inverse relationship between virus-specific HTL responses and viral load, suggesting that HTL play a role in viremia (see, e.g., Rosenberg et al., Science 278:1447, 1997).
A fundamental challenge in the development of an efficacious HIV vaccine is the heterogeneity observed in HIV. The virus, like other retroviruses, rapidly mutates during replication resulting in the generation of virus that can escape anti-viral therapy and immune recognition (Borrow et al., Nature Med. 3:205, 1997). In addition, HIV can be classified into a variety of subtypes that exhibit significant sequence divergence (see, e.g., Lukashov et al., AIDS 12:S43, 1998). In view of the heterogeneous nature of HIV, and the heterogeneous immune response observed with HIV infection, induction of a multi-specific cellular immune response directed simultaneously against multiple HIV epitopes appears to be important for the development of an efficacious vaccine against HIV. There is a need to establish such vaccine embodiments which elicit immune responses of sufficient breadth and vigor to prevent and/or clear HIV infection.
The epitope approach, as we have described, may represent a solution to this challenge, in that it allows the incorporation of various antibody, CTL and HTL epitopes, from various proteins, in a single vaccine compositions. Such a composition may simultaneously target multiple dominant and subdominant epitopes and thereby be used to achieve effective immunization in a diverse population.
The information provided in this section is intended to disclose the presently understood state of the art as of the filing date of the present application. Information is included in this section which was generated subsequent to the priority date of this application. Accordingly, information in this section is not intended, in any way, to delineate the priority date for the invention.
II. SUMMARY OF THE INVENTION
This invention applies our knowledge of the mechanisms by which antigen is recognized by T cells, for example, to develop epitope-based vaccines directed towards-HIV. More specifically, this application communicates our discovery of specific epitope pharmaceutical compositions and methods of use in the prevention and treatment of HIV infection.
Upon development of appropriate technology, the use of epitope-based vaccines has several advantages over current vaccines, particularly when compared to the use of whole antigens in vaccine compositions. There is evidence that the immune response to whole antigens is directed largely toward variable regions of the antigen, allowing for immune escape due to mutations. The epitopes for inclusion in an epitope-based vaccine may be selected from conserved regions of viral or tumor-associated antigens, which thereby reduces the likelihood of escape mutants. Furthermore, immunosuppressive epitopes that may be present in whole antigens can be avoided with the use of epitope-based vaccines.
An additional advantage of an epitope-based vaccine approach is the ability to combine selected epitopes (CTL and HTL), and further, to modify the composition of the epitopes, achieving, for example, enhanced immunogenicity. Accordingly, the immune response can be modulated, as appropriate, for the target disease. Similar engineering of the response is not possible with traditional approaches.
Another major benefit of epitope-based immune-stimulating vaccines is their safety. The possible pathological side effects caused by infectious agents or whole protein antigens, which might have their own intrinsic biological activity, is eliminated.
An epitope-based vaccine also provides the ability to direct and focus an immune response to multiple selected antigens from the same pathogen. Thus, patient-by-patient variability in the immune response to a particular pathogen may be alleviated by inclusion of epitopes from multiple antigens from the pathogen in a vaccine composition. In the case of HIV, epitopes derived from multiple strains may also be included. A “pathogen” may be an infectious agent or a tumor associated molecule.
One of the most formidable obstacles to the development of broadly efficacious epitope-based immunotherapeutics, however, has been the extreme polymorphism of HLA molecules. To date, effective non-genetically biased coverage of a population has been a task of considerable complexity; such coverage has required that epitopes be used that are specific for HLA molecules corresponding to each individual HLA allele.
Impractically large numbers of epitopes would therefore have to be used in order to cover ethnically diverse populations. Thus, there has existed a need for peptide epitopes that are bound by multiple HLA antigen molecules for use in epitope-based vaccines. The greater the number of HLA antigen molecules bound, the greater the breadth of population coverage by the vaccine.
Furthermore, as described herein in greater detail, a need has existed to modulate peptide binding properties, e.g., so that peptides that are able to bind to multiple HLA antigens do so with an affinity that will stimulate an immune response. Identification of epitopes restricted by more than one HLA allele at an affinity that correlates with immunogenicity is important to provide thorough population coverage, and to allow the elicitation of responses of sufficient vigor to prevent or clear an infection in a diverse segment of the population. Such a response can also target a broad array of epitopes. The technology disclosed herein provides for such favored immune responses.
In a preferred embodiment, epitopes for inclusion in vaccine compositions of the invention are selected by a process whereby protein sequences of known antigens are evaluated for the presence of motif or supermotif-bearing epitopes. Peptides corresponding to a motif- or supermotif-bearing epitope are then synthesized and tested for the ability to bind to the HLA molecule that recognizes the selected motif. Those peptides that bind at an intermediate or high affinity i.e., an IC50 (or a KD value) of 500 nM or less for HLA class I molecules or an IC50 of 1000 nM or less for HLA class II molecules, are further evaluated for their ability to induce a CTL or HTL response. Immunogenic peptide epitopes are selected for inclusion in vaccine compositions.
Supermotif-bearing peptides may additionally be tested for the ability to bind to multiple alleles within the HLA supertype family. Moreover, peptide epitopes may be analogued to modify binding affinity and/or the ability to bind to multiple alleles within an HLA supertype.
The invention also includes embodiments comprising methods for monitoring or evaluating an immune response to HIV in a patient having a known HLA-type. Such methods comprise incubating a T lymphocyte sample from the patient with a peptide composition comprising an HIV epitope that has an amino acid sequence described in Tables VII to Table XX which binds the product of at least one HLA allele present in the patient, and detecting for the presence of a T lymphocyte that binds to the peptide. A CTL peptide epitope may, for example, be used as a component of a tetrameric complex for this type of analysis.
An alternative modality for defining the peptide epitopes in accordance with the invention is to recite the physical properties, such as length; primary structure; or charge, which are correlated with binding to a particular allele-specific HLA molecule or group of allele-specific HLA molecules. A further modality for defining peptide epitopes is to recite the physical properties of an HLA binding pocket, or properties shared by several allele-specific HLA binding pockets (e.g. pocket configuration and charge distribution) and reciting that the peptide epitope fits and binds to the pocket or pockets.
As will be apparent from the discussion below, other methods and embodiments are also contemplated. Further, novel synthetic peptides produced by any of the methods described herein are also part of the invention.
III. BRIEF DESCRIPTION OF THE FIGURES
FIG. 1: FIG. 1 provides a graph of total frequency of genotypes as a function of the number of PF candidate epitopes bound by HLA-A and B molecules, in an average population.
FIG. 2: FIG. 2 illustrates the position of peptide epitopes in an experimental model minigene construct.
IV. DETAILED DESCRIPTION OF THE INVENTION
The peptide epitopes and corresponding nucleic acid compositions of the present invention are useful for stimulating an immune response to HIV by stimulating the production of CTL or HTL responses. The peptide epitopes, which are derived directly or indirectly from native HIV protein amino acid sequences, are able to bind to HLA molecules and stimulate an immune response to HIV. The complete sequence of the HIV proteins to be analyzed can be obtained from Genbank. Peptide epitopes and analogs thereof can also be readily determined from sequence information that may subsequently be discovered for heretofore unknown variants of HIV, as will be clear from the disclosure provided below.
The peptide epitopes of the invention have been identified in a number of ways, as will be discussed below. Also discussed in greater detail is that analog peptides have been derived and the binding activity for HLA molecules modulated by modifying specific amino acid residues to create peptide analogs exhibiting altered immunogenicity. Further, the present invention provides compositions and combinations of compositions that enable epitope-based vaccines that are capable of interacting with HLA molecules encoded by various genetic alleles to provide broader population coverage than prior vaccines.
IV.A. Definitions
The invention can be better understood with reference to the following definitions, which are listed alphabetically: A “computer” or “computer system” generally includes: a processor; at least one information storage/retrieval apparatus such as, for example, a hard drive, a disk drive or a tape drive; at least one input apparatus such as, for example, a keyboard, a mouse, a touch screen, or a microphone; and display structure. Additionally, the computer may include a communication channel in communication with a network. Such a computer may include more or less than what is listed above.
“Cross-reactive binding” indicates that a peptide is bound by more than one HLA molecule; a synonym is degenerate binding.
A “cryptic epitope” elicits a response by immunization with an isolated peptide, but the response is not cross-reactive in vitro when intact whole protein which comprises the epitope is used as an antigen.
A “dominant epitope” is an epitope that induces an immune response upon immunization with a whole native antigen (see, e.g., Sercarz, et al., Annu. Rev. Immunol. 11:729-766, 1993). Such a response is cross-reactive in vitro with an isolated peptide epitope.
With regard to a particular amino acid sequence, an “epitope” is a set of amino acid residues which is involved in recognition by a particular immunoglobulin, or in the context of T cells, those residues necessary for recognition by T cell receptor proteins and/or Major Histocompatibility Complex (NMHC) receptors. In an immune system setting, in vivo or in vitro, an epitope is the collective features of a molecule, such as primary, secondary and tertiary peptide structure, and charge, that together form a site recognized by an immunoglobulin, T cell receptor or HLA molecule. Throughout this disclosure epitope and peptide are often used interchangeably. It is to be appreciated, however, that isolated or purified protein or peptide molecules larger than and comprising an epitope of the invention are still within the bounds of the invention. “Human Leukocyte Antigen” or “HLA” is a human class I or class II Major Histocompatibility Complex (MHC) protein (see, e.g., Stites, et al., IMMUNOLOGY, 8TH ED., Lange Publishing, Los Altos, Calif. (1994).
An “HLA supertype or family”, as used herein, describes sets of HLA molecules grouped on the basis of shared peptide-binding specificities. HLA class I molecules that share somewhat similar binding affinity for peptides bearing certain amino acid motifs are grouped into HLA supertypes. The terms HLA superfamily, HLA supertype family, HLA family, and HLA xx-like molecules (where xx denotes a particular HLA type), are synonyms.
Throughout this disclosure, results are expressed in terms of “IC50's.” IC50 is the concentration of peptide in a binding assay at which 50% inhibition of binding of a reference peptide is observed. Given the conditions in which the assays are run (i.e., limiting HLA proteins and labeled peptide concentrations), these values approximate KD values. Assays for determining binding are described in detail, e.g. in PCT publications WO 94/20127 and WO 94/03205. It should be noted that IC50 values can change, often dramatically, if the assay conditions are varied, and depending on the particular reagents used (e.g., HLA preparation, etc.). For example, excessive concentrations of HLA molecules will increase the apparent measured IC50 of a given ligand.
Alternatively, binding is expressed relative to a reference peptide. Although as a particular assay becomes more, or less, sensitive, the IC50's of the peptides tested may change somewhat, the binding relative to the reference peptide will not significantly change. For example, in an assay run under conditions such that the IC50 of the reference peptide increases 10-fold, the IC50 values of the test peptides will also shift approximately 10-fold. Therefore, to avoid ambiguities, the assessment of whether a peptide is a good, intermediate, weak, or negative binder is generally based on its IC50, relative to the IC50 of a standard peptide.
Binding may also be determined using other assay systems including those using: live cells (e.g., Ceppellini et al., Nature 339:392, 1989; Christnick et al., Nature 352:67, 1991; Busch et al., Int. Immunol. 2:443, 19990; Hill et al., J. Immunol. 147:189, 1991; del Guercio et al., J. Immunol. 154:685, 1995), cell free systems using detergent lysates (e.g., Cerundolo et al., J. Immunol. 21:2069, 1991), immobilized purified MHC (e.g., Hill et al., J. Immunol. 152, 2890, 1994; Marshall et al., J. Immunol. 152:4946, 1994), ELISA systems (e.g., Reay et al., EMBO J. 11:2829, 1992), surface plasmon resonance (e.g., Khilko et al., J. Biol. Chem. 268:15425, 1993); high flux soluble phase assays (Hammer et al., J. Exp. Med. 180:2353, 1994), and measurement of class I MHC stabilization or assembly (e.g., Ljunggren et al., Nature 346:476, 1990; Schumacher et al., Cell 62:563, 1990; Townsend et al., Cell 62:285, 1990; Parker et al., J. Immunol. 149:1896, 1992).
As used herein, “high affinity” with respect to HLA class I molecules is defined as binding with an IC50, or KD value, of 50 nM or less; “intermediate affinity” is binding with an IC50 or KD value of between about 50 and about 500 nM. “High affinity” with respect to binding to HLA class II molecules is defined as binding with an IC50 or KD value of 100 nM or less; “intermediate affinity” is binding with an IC50 or KD value of between about 100 and about 1000 nM. The terms “identical” or percent “identity,” in the context of two or more peptide sequences, refer to two or more sequences or subsequences that are the same or have a specified percentage of amino acid residues that are the same, when compared and aligned for maximum correspondence over a comparison window, as measured using a sequence comparison algorithm or by manual alignment and visual inspection.
An “immunogenic peptide” or “peptide epitope” is a peptide that comprises an allele-specific motif or supermotif such that the peptide will bind an HLA molecule and induce a CTL and/or HTL response. Thus, immunogenic peptides of the invention are capable of binding to an appropriate HLA molecule and thereafter inducing a cytotoxic T cell response, or a helper T cell response, to the antigen from which the immunogenic peptide is derived.
The phrases “isolated” or “biologically pure” refer to material which is substantially or essentially free from components which normally accompany the material as it is found in its native state. Thus, isolated peptides in accordance with the invention preferably do not contain materials normally associated with the peptides in their in situ environment.
“Major Histocompatibility Complex” or “MHC” is a cluster of genes that plays a role in control of the cellular interactions responsible for physiologic immune responses.
In humans, the MHC complex is also known as the HLA complex. For a detailed description of the MHC and HLA complexes, see, Paul, FUNDAMENTAL IMMUNOLOGY, 3RD ED., Raven Press, New York, 1993.
The term “motif” refers to the pattern of residues in a peptide of defined length, usually a peptide of from about 8 to about 13 amino acids for a class I HLA motif and from about 6 to about 25 amino acids for a class II HLA motif, which is recognized by a particular HLA molecule. Peptide motifs are typically different for each protein encoded by each human HLA allele and differ in the pattern of the primary and secondary anchor residues.
A “negative binding residue” or “deleterious residue” is an amino acid which, if present at certain positions (typically not primary anchor positions) in a peptide epitope, results in decreased binding affinity of the peptide for the peptide's corresponding HLA molecule.
The term “peptide” is used interchangeably with “oligopeptide” in the present specification to designate a series of residues, typically L-amino acids, connected one to the other, typically by peptide bonds between the α-amino and carboxyl groups of adjacent amino acids. The preferred CTL-inducing peptides of the invention are 13 residues or less in length and usually consist of between about 8 and about 11 residues, preferably 9 or 10 residues. The preferred HTL-inducing oligopeptides are less than about 50 residues in length and usually consist of between about 6 and about 30 residues, more usually between about 12 and 25, and often between about 15 and 20 residues. “Pharmaceutically acceptable” refers to a non-toxic, inert, and/or physiologically compatible composition.
A “primary anchor residue” is an amino acid at a specific position along a peptide sequence which is understood to provide a contact point between the immunogenic peptide and the HLA molecule. One to three, usually two, primary anchor residues within a peptide of defined length generally defines a “motif” for an immunogenic peptide. These residues are understood to fit in close contact with peptide binding grooves of an HLA molecule, with their side chains buried in specific pockets of the binding grooves themselves. In one embodiment, for example, the primary anchor residues are located at position 2 (from the amino terminal position) and at the carboxyl terminal position of a 9-residue peptide epitope in accordance with the invention. The primary anchor positions for each motif and supermotif are set forth in Table 1. For example, analog peptides can be created by altering the presence or absence of particular residues in these primary anchor positions. Such analogs are used to modulate the binding affinity of a peptide comprising a particular motif or supermotif.
“Promiscuous recognition” is where a distinct peptide is recognized by the same T cell clone in the context of various HLA molecules. Promiscuous recognition or binding is synonymous with cross-reactive binding.
A “protective immune response” or “therapeutic immune response” refers to a CTL and/or an HTL response to an antigen derived from an infectious agent or a tumor antigen, which prevents or at least partially arrests disease symptoms or progression. The immune response may also include an antibody response which has been facilitated by the stimulation of helper T cells.
The term “residue” refers to an amino acid or amino acid mimetic incorporated into an oligopeptide by an amide bond or amide bond mimetic.
A “secondary anchor residue” is an amino acid at a position other than a primary anchor position in a peptide which may influence peptide binding. A secondary anchor residue occurs at a significantly higher frequency amongst bound peptides than would be expected by random distribution of amino acids at one position. The secondary anchor residues are said to occur at “secondary anchor positions.” A secondary anchor residue can be identified as a residue which is present at a higher frequency among high or intermediate affinity binding peptides, or a residue otherwise associated with high or intermediate affinity binding. For example, analog peptides can be created by altering the presence or absence of particular residues in these secondary anchor positions. Such analogs are used to finely modulate the binding affinity of a peptide comprising a particular motif or supermotif.
A “subdominant epitope” is an epitope which evokes little or no response upon immunization with whole antigens which comprise the epitope, but for which a response can be obtained by immunization with an isolated peptide, and this response (unlike the case of cryptic epitopes) is detected when whole protein is used to recall the response in vitro or in vivo.
A “supermotif” is a peptide binding specificity shared by HLA molecules encoded by two or more HLA alleles. Preferably, a supermotif-bearing peptide is recognized with high or intermediate affinity (as defined herein) by two or more HLA antigens.
“Synthetic peptide” refers to a peptide that is not naturally occurring, but is man-made using such methods as chemical synthesis or recombinant DNA technology.
The nomenclature used to describe peptide compounds follows the conventional practice wherein the amino group is presented to the left (the N-terminus) and the carboxyl group to the right (the C-terminus) of each amino acid residue. When amino acid residue positions are referred to in a peptide epitope they are numbered in an amino to carboxyl direction with position one being the position closest to the amino terminal end of the epitope, or the peptide or protein of which it may be a part. In the formulae representing selected specific embodiments of the present invention, the amino- and carboxyl-terminal groups, although not specifically shown, are in the form they would assume at physiologic pH values, unless otherwise specified. In the amino acid structure formulae, each residue is generally represented by standard three letter or single letter designations. The L-form of an amino acid residue is represented by a capital single letter or a capital first letter of a three-letter symbol, and the D-form for those amino acids having D-forms is represented by a lower case single letter or a lower case three letter symbol. Glycine has no asymmetric carbon atom and is simply referred to as “Gly” or G. Symbols for the amino acids are shown below.
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Single Letter SymbolThree Letter SymbolAmino Acids
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AAlaAlanine
CCysCysteine
DAspAspartic Acid
EGluGlutamic Acid
FPhePhenylalanine
GGlyGlycine
HHisHistidine
IIleIsoleucine
KLysLysine
LLeuLeucine
MMetMethionine
NAsnAsparagine
PProProline
QGlnGlutamine
RArgArginine
SSerSerine
TThrThreonine
VValValine
WTrpTryptophan
YTyrTyrosine
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IV.B. Stimulation of CTL and HTL Responses
The mechanism by which T cells recognize antigens has been delineated during the past ten years. Based on our understanding of the immune system we have developed efficacious peptide epitope vaccine compositions that can induce a therapeutic or prophylactic immune response to HIV in a broad population. For an understanding of the value and efficacy of the claimed compositions, a brief review of immunology-related technology is provided.
A complex of an HLA molecule and a peptidic antigen acts as the ligand recognized by HLA-restricted T cells (Buus, S. et al., Cell 47:1071, 1986; Babbitt, B. P. et al., Nature 317:359, 1985; Townsend, A. and Bodmer, H., Annu. Rev. Immunol. 7:601, 1989; Germain, R. N., Annu. Rev. Immunol. 11:403, 1993). Through the study of single amino acid substituted antigen analogs and the sequencing of endogenously bound, naturally processed peptides, critical residues that correspond to motifs required for specific binding to HLA antigen molecules have been identified and are described herein and are set forth in Tables I, II, and III (see also, e.g., Southwood, et al., J. Immunol. 160:3363, 1998; Rammensee, et al., Immunogenetics 41:178, 1995; Rammensee et al., SYFPEITHI, access via web at : http:H/134.2.96.221/scripts.hlaserver.dll/home.htm; Sette, A. and Sidney, J. Curr. Opin. Immunol. 10:478, 1998; Engelhard, V. H., Curr. Opin. Immunol. 6:13, 1994; Sette, A. and Grey, H. M., Curr. Opin. Immunol. 4:79, 1992; Sinigaglia, F. and Hammer, J. Curr. Biol. 6:52, 1994; Ruppert et al., Cell 74:929-937, 1993; Kondo et al., J. Immunol. 155:4307-4312, 1995; Sidney et al., J. Immunol. 157:3480-3490, 1996; Sidney et al., Human Immunol. 45:79-93, 1996; Sette, A. and Sidney, J. Immunogenetics, in press, 1999).
Furthermore, x-ray crystallographic analysis of HLA-peptide complexes has revealed pockets within the peptide binding cleft of HLA molecules which accommodate, in an allele-specific mode, residues borne by peptide ligands; these residues in turn determine the HLA binding capacity of the peptides in which they are present. (See, e.g., Madden, D. R. Annu. Rev. Immunol. 13:587, 1995; Smith, et al., Immunity 4:203, 1996; Fremont et al., Immunity 8:305, 1998; Stem et al., Structure 2:245, 1994; Jones, E. Y. Curr. Opin. Immunol. 9:75, 1997; Brown, J. H. et al., Nature 364:33, 1993; Guo, H. C. et al., Proc. Natl. Acad. Sci. USA 90:8053, 1993; Guo, H. C. et al., Nature 360:364, 1992; Silver, M. L. et al., Nature 360:367, 1992; Matsumura, M. et al., Science 257:927, 1992; Madden et al., Cell 70:1035, 1992; Fremont, D. H. et al., Science 257:919, 1992; Saper, M. A., Bjorkman, P. J. and Wiley, D. C., J. Mol. Biol. 219:277, 1991.) Accordingly, the definition of class I and class II allele-specific HLA binding motifs, or class I or class II supermotifs allows identification of regions within a protein that have the potential of binding particular HLA antigen(s).
The present inventors have found that the correlation of binding affinity with immunogenicity, which is disclosed herein, is an important factor to be considered when evaluating candidate peptides. Thus, by a combination of motif searches and HLA-peptide binding assays, candidates for epitope-based vaccines have been identified. After determining their binding affinity, additional confirmatory work can be performed to select, amongst these vaccine candidates, epitopes with preferred characteristics in terms of population coverage, antigenicity, and immunogenicity.
Various strategies can be utilized to evaluate immunogenicity, including:
- 1) Evaluation of primary T cell cultures from normal individuals (see, e.g., Wentworth, P. A. et al., Mol. Immunol. 32:603, 1995; Celis, E. et al., Proc. Natl. Acad. Sci. USA 91:2105, 1994; Tsai, V. et al., J. Immunol. 158:1796, 1997; Kawashima, I. et al., Human Immunol. 59:1, 1998); This procedure involves the stimulation of peripheral blood lymphocytes (PBL) from normal subjects with a test peptide in the presence of antigen presenting cells in vitro over a period of several weeks. T cells specific for the peptide become activated during this time and are detected using, e.g., a 51Cr-release assay involving peptide sensitized target cells.
2) Immunization of HLA transgenic mice (see, e.g., Wentworth, P. A. et al., J. Immunol. 26:97, 1996; Wentworth, P. A. et al., Int. Immunol. 8:651, 1996; Alexander, J. et al., J. Immunol. 159:4753, 1997); In this method, peptides in incomplete Freund's adjuvant are administered subcutaneously to HLA transgenic mice. Several weeks following immunization, splenocytes are removed and cultured in vitro in the presence of test peptide for approximately one week. Peptide-specific T cells are detected using, e.g., a 51Cr-release assay involving peptide sensitized target cells and target cells expressing endogenously generated antigen.
3) Demonstration of recall T cell responses from immune individuals who have effectively been vaccinated, recovered from infection, and/or from chronically infected patients (see, e.g., Rehermann, B. et al., J. Exp. Med. 181:1047, 1995; Doolan, D. L. et al., Immunity 7:97, 1997; Bertoni, R. et al., J. Clin. Invest. 100:503, 1997; Threlkeld, S. C. et al., J. Immunol. 159:1648, 1997; Diepolder, H. M. et al., J. Virol. 71:6011, 1997); In applying this strategy, recall responses are detected by culturing PBL from subjects that have been naturally exposed to the antigen, for instance through infection, and thus have generated an immune response “naturally”, or from patients who were vaccinated against the infection. PBL from subjects are cultured in vitro for 1-2 weeks in the presence of test peptide plus antigen presenting cells (APC) to allow activation of “memory” T cells, as compared to “naive” T cells. At the end of the culture period, T cell activity is detected using assays for T cell activity including 51 Cr release involving peptide-sensitized targets, T cell proliferation, or lymphokine release.
The following describes the peptide epitopes and corresponding nucleic acids of the invention.
IV.C. Binding Affinity of Peptide Epitopes for HLA Molecules
As indicated herein, the large degree of HLA polymorphism is an important factor to be taken into account with the epitope-based approach to vaccine development. To address this factor, epitope selection encompassing identification of peptides capable of binding at high or intermediate affinity to multiple HLA molecules is preferably utilized, most preferably these epitopes bind at high or intermediate affinity to two or more allele-specific HLA molecules.
CTL-inducing peptides of interest for vaccine compositions preferably include those that have an IC50 or binding affinity value for class I HLA molecules of 500 nM or better (i.e., the value is <500 nM). HTL-inducing peptides preferably include those that have an IC50 or binding affinity value for class II HLA molecules of 1000 nM or better, (i.e., the value is ≦1,000 nM). For example, peptide binding is assessed by testing the capacity of a candidate peptide to bind to a purified HLA molecule in vitro. Peptides exhibiting high or intermediate affinity are then considered for further analysis. Selected peptides are tested on other members of the supertype family. In preferred embodiments, peptides that exhibit cross-reactive binding are then used in cellular screening analyses or vaccines.
As disclosed herein, higher HLA binding affinity is correlated with greater immunogenicity. Greater immunogenicity can be manifested in several different ways. Immunogenicity corresponds to whether an immune response is elicited at all, and to the vigor of any particular response, as well as to the extent of a population in which a response is elicited. For example, a peptide might elicit an immune response in a diverse array of the population, yet in no instance produce a vigorous response. In accordance with these principles, close to 90% of high binding peptides have been found to be immunogenic, as contrasted with about 50% of the peptides which bind with intermediate affinity. Moreover, higher binding affinity peptides lead to more vigorous immunogenic responses. As a result, less peptide is required to elicit a similar biological effect if a high affinity binding peptide is used. Thus, in preferred embodiments of the invention, high affinity binding epitopes are particularly useful.
The relationship between binding affinity for HLA class I molecules and immunogenicity of discrete peptide epitopes on bound antigens has been determined for the first time in the art by the present inventors. The correlation between binding affinity and immunogenicity was analyzed in two different experimental approaches (see, e.g., Sette, et al., J. Immunol. 153:5586-5592, 1994). In the first approach, the immunogenicity of potential epitopes ranging in HLA binding affinity over a 10,000-fold range was analyzed in HLA-A*0201 transgenic mice. In the second approach, the antigenicity of approximately 100 different hepatitis B virus (HBV)-derived potential epitopes, all carrying A*0201 binding motifs, was assessed by using PBL from acute hepatitis patients. Pursuant to these approaches, it was determined that an affinity threshold value of approximately 500 nM (preferably 50 rM or less) determines the capacity of a peptide epitope to elicit a CTL response. These data are true for class I binding affinity measurements for naturally processed peptides and for synthesized T cell epitopes. These data also indicate the important role of determinant selection in the shaping of T cell responses (see, e.g., Schaeffer et al. Proc. Natl. Acad. Sci. USA 86:4649-4653, 1989).
An affinity threshold associated with immunogenicity in the context of HLA class II DR molecules has also been delineated (see, e.g., Southwood et al. J. Immunology 160:3363-3373,1998, and co-pending U.S. Ser. No. 09/009,953 filed Jan. 21, 1998). In order to define a biologically significant threshold of DR binding affinity, a database of the binding affinities of 32 DR-restricted epitopes for their restricting element (i.e., the HLA molecule that binds the motif) was compiled. In approximately half of the cases (15 of 32 epitopes), DR restriction was associated with high binding affinities, i.e. binding affinity values of 100 nM or less. In the other half of the cases (16 of 32), DR restriction was associated with intermediate affinity (binding affinity values in the 100-1000 nM range). In only one of 32 cases was DR restriction associated with an IC50 of 1000 nM or greater. Thus, 1000 nM can be defined as an affinity threshold associated with immunogenicity in the context of DR molecules.
The binding affinity of peptides for HLA molecules can be determined as described in Example 1, below.
IV.D. Peptide Epitope Binding Motifs and Supermotifs
Through the study of single amino acid substituted antigen analogs and the sequencing of endogenously bound, naturally processed peptides, critical residues required for allele-specific binding to HLA molecules have been identified. The presence of these residues correlates with binding affinity for HLA molecules. The identification of motifs and/or supermotifs that correlate with high and intermediate affinity binding is an important issue with respect to the identification of immunogenic peptide epitopes for the inclusion in a vaccine. Kast et al. (J. Immunol. 152:3904-3912, 1994) have shown that motif-bearing peptides account for 90% of the epitopes that bind to allele-specific HLA class I molecules. In this study all possible peptides of 9 amino acids in length and overlapping by eight amino acids (240 peptides), which cover the entire sequence of the E6 and E7 proteins of human papillomavirus type 16, were evaluated for binding to five allele-specific HLA molecules that are expressed at high frequency among different ethnic groups. This unbiased set of peptides allowed an evaluation of the predictive value of HLA class I motifs. From the set of 240 peptides, 22 peptides were identified that bound to an allele-specific HLA molecule with high or intermediate affinity. Of these 22 peptides, 20 (i.e. 91%) were motif-bearing. Thus, this study demonstrates the value of motifs for the identification of peptide epitopes for inclusion in a vaccine: application of motif-based identification techniques will identify about 90% of the potential epitopes in a target antigen protein sequence.
Such peptide epitopes are identified in the Tables described below. Peptides of the present invention may also comprise epitopes that bind to MHC class II DR molecules. A greater degree of heterogeneity in both size and binding frame position of the motif, relative to the N and C termini of the peptide, exists for class II peptide ligands. This increased heterogeneity of HLA class II peptide ligands is due to the structure of the binding groove of the HLA class II molecule which, unlike its class I counterpart, is open at both ends. Crystallographic analysis of HLA class II DRB*0101-peptide complexes showed that the major energy of binding is contributed by peptide residues complexed with complementary pockets on the DRB*0101 molecules. An important anchor residue engages the deepest hydrophobic pocket (see, e.g., Madden, D. R. Ann. Rev. Immunol. 13:587, 1995) and is referred to as position 1 (P1). P1 may represent the N-terminal residue of a class II binding peptide epitope, but more typically is flanked towards the N-terminus by one or more residues. Other studies have also pointed to an important role for the peptide residue in the 6th position towards the C-terminus, relative to PI, for binding to various DR molecules.
In the past few years evidence has accumulated to demonstrate that a large fraction of HLA class I and class II molecules can be classified into a relatively few supertypes, each characterized by largely overlapping peptide binding repertoires, and consensus structures of the main peptide binding pockets. Thus, peptides of the present invention are identified by any one of several HLA-specific amino acid motifs (see, e.g., Tables I-III), or if the presence of the motif corresponds to the ability to bind several allele-specific HLA antigens, a supermotif The HLA molecules that bind to peptides that possess a particular amino acid supermotif are collectively referred to as an HLA “supertype.”
The peptide motifs and supermotifs described below, and summarized in Tables I-III, provide guidance for the identification and use of peptide epitopes in accordance with the invention.
Examples of peptide epitopes bearing a respective supermotif or motif are included in Tables as designated in the description of each motif or supermotif below. The Tables include a binding affinity ratio listing for some of the peptide epitopes. The ratio may be converted to IC50 by using the following formula: IC50 of the standard peptide/ratio=IC50 of the test peptide (i.e., the peptide epitope). The IC50 values of standard peptides used to determine binding affinities for Class I peptides are shown in Table IV. The IC50 values of standard peptides used to determine binding affinities for Class II peptides are shown in Table V. The peptides used as standards for the binding assays described herein are examples of standards; alternative standard peptides can also be used when performing binding studies.
To obtain the peptide epitope sequences listed in each Table, protein sequence data for all of the HIV-1 isolates present in the 1999 Los Alamos database (http://hiv-web.lanl.gov) were evaluated for the presence of the designated supermotif or motif. A listing of the strains is provided in Table XXVI. Nine HIV-1 structural and regulatory proteins, gag, pol, env, nef, rev, tat, vif, vpr, and vpu, were included in the analysis. Peptide epitopes were additionally evaluated on the basis of their conservancy (i.e., the amount of variance) among the available protein sequences for each HIV antigen. A criterion for conservancy used to generate the peptides set out in Tables VII-XX requires that the entire sequence of an HLA class I binding peptide be totally conserved in 15% of the sequences available for a specific HIV antigen. Similarly, a criterion for conservancy requires that the entire 9-mer core region of an HLA class II binding peptide be totally conserved in 15% of the sequences available for a specific protein. The percent conservancy of the selected peptide epitopes is indicated on the Tables. The frequency, i.e. the number of sequences of the HIV protein antigen in which the totally conserved peptide sequence was identified, is also shown. The “pos” (position) column in the Tables designates the amino acid position in the HIV protein that corresponds to the first amino acid residue of the epitope. The “number of amino acids” indicates the number of residues in the epitope sequence.
HLA Class I Motifs Indicative of CTL Inducing Peptide Epitopes:
The primary anchor residues of the HLA class I peptide epitope supermotifs and motifs delineated below are summarized in Table I. The HLA class I motifs set out in Table I(a) are those most particularly relevant to the invention claimed here. Primary and secondary anchor positions are summarized in Table II. Allele-specific HLA molecules that comprise HLA class I supertype families are listed in Table VI. In some cases, peptide epitopes may be listed in both a motif and a supermotif Table. The relationship of a particular motif and respective supermotif is indicated in the description of the individual motifs.
IV.D.1. HLA-A1 supermotif
The HLA-A1 supermotif is characterized by the presence in peptide ligands of a small (T or S) or hydrophobic (L, I, V, or M) primary anchor residue in position 2, and an aromatic (Y, F, or W) primary anchor residue at the C-terminal position of the epitope. The corresponding family of HLA molecules that bind to the A1 supermotif (i.e., the HLA-A1 supertype) is comprised of at least A*0101, A*2601, A*2602, A*2501, and A*3201 (see, e.g., DiBrino, M. et al., J. Immunol. 151:5930, 1993; DiBrino, M. et al., J. Immunol. 152:620, 1994; Kondo, A. et al., Immunogenetics 45:249, 1997). Other allele-specific HLA molecules predicted to be members of the A1 superfamily are shown in Table VI. Peptides binding to each of the individual HLA proteins can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the A1 supermotif are set forth on the attached Table VII.
IV.D.2. HLA-A2 Supermotif
Primary anchor specificities for allele-specific HLA-A2.1 molecules (see, e.g., Falk et al., Nature 351:290-296, 1991; Hunt et al., Science 255:1261-1263, 1992; Parker et al., J. Immunol. 149:3580-3587, 1992; Ruppert et al., Cell 74:929-937, 1993) and cross-reactive binding among HLA-A2 and -A28 molecules have been described. (See, e.g., Fruci et al., Human Immunol. 38:187-192, 1993; Tanigaki et al., Human Immunol. 39:155-162, 1994; Del Guercio et al., J. Immunol. 154:685-693, 1995; Kast et al., J. Immunol. 152:3904-3912, 1994 for reviews of relevant data.) These primary anchor residues define the HLA-A2 supermotif; which presence in peptide ligands corresponds to the ability to bind several different HLA-A2 and -A28 molecules. The HLA-A2 supermotif comprises peptide ligands with L, I, V, M, A, T, or Q as a primary anchor residue at position 2 and L, I, V, M, A, or T as a primary anchor residue at the C-terminal position of the epitope.
The corresponding family of HLA molecules (i.e., the HLA-A2 supertype that binds these peptides) is comprised of at least: A*0201, A*0202, A*0203, A*0204, A*0205, A*0206, A*0207, A*0209, A*0214, A*6802, and A*6901. Other allele-specific HLA molecules predicted to be members of the A2 superfamily are shown in Table VI. As explained in detail below, binding to each of the individual allele-specific HLA molecules can be modulated by substitutions at the primary anchor and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise an A2 supermotif are set forth on the attached Table VIII. The motifs comprising the primary anchor residues V, A, T, or Q at position 2 and L, I, V, A, or T at the C-terminal position are those most particularly relevant to the invention claimed herein.
IV.D.3. HLA-A3 Supermotif
The HLA-A3 supermotif is characterized by the presence in peptide ligands of A, L, I, V, M, S, or, T as a primary anchor at position 2, and a positively charged residue, R or K, at the C-terminal position of the epitope, e.g., in position 9 of 9-mers (see, e.g., Sidney et al., Hum. Immunol. 45:79, 1996). Exemplary members of the corresponding family of HLA molecules (the HLA-A3 supertype) that bind the A3 supermotif include at least A*0301, A*1101, A*3101, A*3301, and A*6801. Other allele-specific HLA molecules predicted to be members of the A3 supertype are shown in Table VI. As explained in detail below, peptide binding to each of the individual allele-specific HLA proteins can be modulated by substitutions of amino acids at the primary and/or secondary anchor positions of the peptide, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the A3 supermotif are set forth on the attached Table IX.
IV.D.4. HLA-A24 Supermotif
The HLA-A24 supermotif is characterized by the presence in peptide ligands of an aromatic (F, W, or Y) or hydrophobic aliphatic (L, I, V, M, or T) residue as a primary anchor in position 2, and Y, F, W, L, I, or M as primary anchor at the C-terminal position of the epitope (see, e.g., Sette and Sidney, Immunogenetics, in press, 1999). The corresponding family of HLA molecules that bind to the A24 supermotif (i.e., the A24 supertype) includes at least A*2402, A*3001, and A*2301. Other allele-specific HLA molecules predicted to be members of the A24 supertype are shown in Table VI. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the A24 supermotif are set forth on the attached Table X.
IV.D.5. HLA-B7 Supermotif
The HLA-B7 supermotif is characterized by peptides bearing proline in position 2 as a primary anchor, and a hydrophobic or aliphatic amino acid (L, I, V, M, A, F, W, or Y) as the primary anchor at the C-terminal position of the epitope. The corresponding family of HLA molecules that bind the B7 supermotif (i.e., the HLA-B7 supertype) is comprised of at least twenty six HLA-B proteins including: B*0702, B*0703, B*0704, B*0705, B*1508, B*3501, B*3502, B*3503, B*3504, B*3505, B*3506, B*3507, B*3508, B*5101, B*5102, B*5103, B*5104, B*5105, B*5301, B*5401, B*5501, B*5502, B*5601, B*5602, B*6701, and B*7801 (see, e.g., Sidney, et al., J. Immunol. 154:247, 1995; Barber, et al., Curr. Biol. 5:179, 1995; Hill, et al., Nature 360:434, 1992; Rammensee, et al., Immunogenetics 41:178, 1995 for reviews of relevant data). Other allele-specific HLA molecules predicted to be members of the B7 supertype are shown in Table VI. As explained in detail below, peptide binding to each of the individual allele-specific HLA proteins can be modulated by substitutions at the primary and/or secondary anchor positions of the peptide, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the B7 supermotif are set forth on the attached Table XI.
IV.D.6. HLA-B27 Supermotif
The HLA-B27 supermotif is characterized by the presence in peptide ligands of a positively charged (R, H, or K) residue as a primary anchor at position 2, and a hydrophobic (F, Y, L, W, M, I, A, or V) residue as a primary anchor at the C-terminal position of the epitope (see, e.g., Sidney and Sette, Immunogenetics, in press, 1999). Exemplary members of the corresponding family of HLA molecules that bind to the B27 supermotif (i.e., the B27 supertype) include at least B*1401, B*1402, B*1509, B*2702, B*2703, B*2704, B*2705, B*2706, B*3801, B*3901, B*3902, and B*7301. Other allele-specific HLA molecules predicted to be members of the B27 supertype are shown in Table VI. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the B27 supermotif are set forth on the attached Table XII.
IV.D.7. HLA-B44 Supermotif
The HLA-B44 supermotif is characterized by the presence in peptide ligands of negatively charged (D or E) residues as a primary anchor in position 2, and hydrophobic residues (F, W, Y, L, I, M, V, or A) as a primary anchor at the C-terminal position of the epitope (see, e.g., Sidney et al., Immunol. Today 17:261, 1996). Exemplary members of the corresponding family of HLA molecules that bind to the B44 supermotif (i.e., the B44 supertype) include at least: B*1801, B*1802, B*3701, B*4001, B*4002, B*4006, B*4402, B*4403, and B*4006. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary and/or secondary anchor positions; preferably choosing respective residues specified for the supermotif
IV.D.8. HLA-B58 Supermotif
The HLA-B58 supermotif is characterized by the presence in peptide ligands of a small aliphatic residue (A, S, or T) as a primary anchor residue at position 2, and an aromatic or hydrophobic residue (F, W, Y, L, I, V, M, or A) as a primary anchor residue at the C-terminal position of the epitope (see, e.g., Sidney and Sette, Immunogenetics, in press, 1999 for reviews of relevant data). Exemplary members of the corresponding family of HLA molecules that bind to the B58 supermotif (i.e., the B58 supertype) include at least: B*1516, B*1517, B*5701, B*5702, and B*5801. Other allele-specific HLA molecules predicted to be members of the B58 supertype are shown in Table VI. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the B58 supermotif are set forth on the attached Table XIII.
IV.D.9. HLA-B62 Supermotif
The HLA-B62 supermotif is characterized by the presence in peptide ligands of the polar aliphatic residue Q or a hydrophobic aliphatic residue (L, V, M, I, or P) as a primary anchor in position 2, and a hydrophobic residue (F, W, Y, M, I, V, L, or A) as a primary anchor at the C-terminal position of the epitope (see, e.g., Sidney and Sette, Immunogenetics, in press, 1999). Exemplary members of the corresponding family of HLA molecules that bind to the B62 supermotif (i.e., the B62 supertype) include at least: B*1501, B*1502, B*1513, and B5201. Other allele-specific HLA molecules predicted to be members of the B62 supertype are shown in Table VI. Peptide binding to each of the allele-specific HLA molecules can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Representative peptide epitopes that comprise the B62 supermotif are set forth on the attached Table XIV.
IV.D.10. HLA-A1 Motif
The HLA-A1 motif is characterized by the presence in peptide ligands of T, S, or M as a primary anchor residue at position 2 and the presence of Y as a primary anchor residue at the C-terminal position of the epitope. An alternative allele-specific A1 motif is characterized by a primary anchor residue at position 3 rather than position 2. This motif is characterized by the presence of D, E, A, or S as a primary anchor residue in position 3, and a Y as a primary anchor residue at the C-terminal position of the epitope (see, e.g., DiBrino et al., J. Immunol., 152:620, 1994; Kondo et al., Immunogenetics 45:249, 1997; and Kubo et al., J. Immunol. 152:3913, 1994 for reviews of relevant data). Peptide binding to HLA A1 can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the motif.
Representative peptide epitopes that comprise either A1 motif are set forth on the attached Table XV. Those epitopes comprising T, S, or M at position 2 and Y at the C-terminal position are also included in the listing of HLA-A1 supermotif-bearing peptide epitopes listed in Table VII, as these residues are a subset of the A1 supermotif primary anchors.
IV.D.11. HLA-A*0201 Motif
An HLA-A2*0201 motif was determined to be characterized by the presence in peptide ligands of L or M as a primary anchor residue in position 2, and L or V as a primary anchor residue at the C-terminal position of a 9-residue peptide (see, e.g. Falk et al., Nature 351:290-296, 1991) and was further found to comprise an I at position 2 and I or A at the C-terminal position of a nine amino acid peptide (see, e.g., Hunt et al., Science 255:1261-1263, Mar. 6, 1992; Parker et al., J. Immunol. 149:3580-3587, 1992). The A*0201 allele-specific motif has also been defined by the present inventors to additionally comprise V, A, T, or Q as a primary anchor residue at position 2, and M or T as a primary anchor residue at the C-terminal position of the epitope (see, e.g., Kast et al., J. Immunol. 152:3904-3912, 1994). Thus, the HLA-A*0201 motif comprises peptide ligands with L, I, V, M, A, T, or Q as primary anchor residues at position 2 and L, I, V, M, A, or T as a primary anchor residue at the C-terminal position of the epitope. The preferred and tolerated residues that characterize the primary anchor positions of the HLA-A*0201 motif are identical to the residues describing the A2 supermotif. (For reviews of relevant data, see, e.g., Del Guercio et al., J. Immunol. 154:685-693, 1995; Ruppert et al., Cell 74:929-937, 1993; Sidney et al., Immunol. Today 17:261-266, 1996; Sette and Sidney, Curr. Opin. in Immunol. 10:478-482, 1998). Secondary anchor residues that characterize the A*0201 motif have additionally been defined (see, e.g., Ruppert et al., Cell 74:929-937, 1993). These are shown in Table II. Peptide binding to HLA-A*0201 molecules can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the motif.
Representative peptide epitopes that comprise an A*0201 motif are set forth on the attached Table VIII. The A*0201 motifs comprising the primary anchor residues V, A, T, or Q at position 2 and L, I, V, A, or T at the C-terminal position are those most particularly relevant to the invention claimed herein.
IV.D.12. HLA-A3 Motif
The HLA-A3 motif is characterized by the presence in peptide ligands of L, M, V, I, S, A, T, F, C, G, or D as a primary anchor residue at position 2, and the presence of K, Y, R, H, F, or A as a primary anchor residue at the C-terminal position of the epitope (see, e.g., DiBrino et al., Proc. Natl. Acad. Sci USA 90:1508, 1993; and Kubo et al., J. Immunol. 152:3913-3924, 1994). Peptide binding to HLA-A3 can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the motif.
Representative peptide epitopes that comprise the A3 motif are set forth on the attached Table XVI. Those peptide epitopes that also comprise the A3 supermotif are also listed in Table IX. The A3 supermotif primary anchor residues comprise a subset of the A3- and A11-allele specific motif primary anchor residues.
IV.D.13. HLA-A11 Motif
The HLA-A 11 motif is characterized by the presence in peptide ligands of V, T, M, L, I, S, A, G, N, C, D, or F as a primary anchor residue in position 2, and K, R, Y, or H as a primary anchor residue at the C-terminal position of the epitope (see, e.g., Zhang et al., Proc. Natl. Acad. Sci USA 90:2217-2221, 1993; and Kubo et al., J. Immunol. 152:3913-3924, 1994). Peptide binding to HLA-A11 can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the motif.
Representative peptide epitopes that comprise the A11 motif are set forth on the attached Table XVII; peptide epitopes comprising the A3 allele-specific motif are also present in this Table because of the extensive overlap between the A3 and A11 motif primary anchor specificities. Further, those peptide epitopes that comprise the A3 supermotif are also listed in Table IX.
IV.D.14. HLA-A24 Motif
The HLA-A24 motif is characterized by the presence in peptide ligands of Y, F, W, or M as a primary anchor residue in position 2, and F, L, I, or W as a primary anchor residue at the C-terminal position of the epitope (see, e.g., Kondo et al., J. Immunol. 155:4307-4312, 1995; and Kubo et al., J. Immunol. 152:3913-3924, 1994). Peptide binding to HLA-A24 molecules can be modulated by substitutions at primary and/or secondary anchor positions; preferably choosing respective residues specified for the motif.
Representative peptide epitopes that comprise the A24 motif are set forth on the attached Table XVIII. These epitopes are also listed in Table X, which sets forth HLA-A24-supermotif-bearing peptide epitopes, as the primary anchor residues characterizing the A24 allele-specific motif comprise a subset of the A24 supermotif primary anchor residues.
Motifs Indicative of Class II HTL Inducing Peptide Epitopes
The primary and secondary anchor residues of the HLA class II peptide epitope supermotifs and motifs delineated below are summarized in Table III.
IV.D.15. HLA DR-14-7 Supermotif
Motifs have also been identified for peptides that bind to three common HLA class II allele-specific HLA molecules: HLA DRB1*0401, DRB1*0101, and DRB1*0701 (see, e.g., the review by Southwood et al. J. Immunology 160:3363-3373,1998). Collectively, the common residues from these motifs delineate the HLA DR-1-4-7 supermotif. Peptides that bind to these DR molecules carry a supermotif characterized by a large aromatic or hydrophobic residue (Y, F, W, L, I, V, or M) as a primary anchor residue in position 1, and a small, non-charged residue (S, T, C, A, P, V, I, L, or M) as a primary anchor residue in position 6 of a 9-mer core region. Allele-specific secondary effects and secondary anchors for each of these HLA types have also been identified (Southwood et al., supra). These are set forth in Table III. Peptide binding to HLA-DRB1*0401, DRB1*0101, and/or DRB1*0701 can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the supermotif.
Conserved 9-mer core regions (i.e., sequences that are 100% conserved in at least 15% of the HIV antigen protein sequences used for the analysis), comprising the DR-1-4-7 supermotif, wherein position 1 of the supermotif is at position 1 of the nine-residue core, are set forth in Table XLXa. Respective exemplary peptide epitopes of 15 amino acid residues in length, each of which comprise a conserved nine residue core, are also shown in section “a” of the Table. Cross-reactive binding data for exemplary 15-residue supermotif-bearing peptides are shown in Table XIXb.
IV.D.16. HLA DR3 Motifs
Two alternative motifs (i.e., submotifs) characterize peptide epitopes that bind to HLA-DR3 molecules (see, e.g., Geluk et al., J. Immunol. 152:5742, 1994). In the first motif (submotif DR3A) a large, hydrophobic residue (L, I, V, M, F, or Y) is present in anchor position I of a 9-mer core, and D is present as an anchor at position 4, towards the carboxyl terminus of the epitope. As in other class II motifs, core position I may or may not occupy the peptide N-terminal position.
The alternative DR3 submotif provides for lack of the large, hydrophobic residue at anchor position 1, and/or lack of the negatively charged or amide-like anchor residue at position 4, by the presence of a positive charge at position 6 towards the carboxyl terminus of the epitope. Thus, for the alternative allele-specific DR3 motif (submotif DR3B): L, I, V, M, F, Y, A, or Y is present at anchor position 1; D, N, Q, E, S, or T is present at anchor position 4; and K, R, or H is present at anchor position 6. Peptide binding to HLA-DR3 can be modulated by substitutions at primary and/or secondary anchor positions, preferably choosing respective residues specified for the motif.
Conserved 9-mer core regions (i.e., those sequences that are 100% conserved in at least 15% of the HIV antigen protein sequences used for the analysis) corresponding to a nine residue sequence comprising the DR3A submotif (wherein position I of the motif is at position 1 of the nine residue core) are set forth in Table XXa. Respective exemplary peptide epitopes of 15 amino acid residues in length, each of which comprise a conserved nine residue core, are also shown in Table XXa. Table XXb shows binding data of exemplary DR3 submotif A-bearing peptides.
Conserved 9-mer core regions (i.e., those that are 100% conserved in at least 15% of the HIV antigen protein sequences used for the analysis) comprising the DR3B submotif and respective exemplary 15-mer peptides comprising the DR3 submotif-B epitope are set forth in Table XXc. Table XXd shows binding data of exemplary DR3 submotif B-bearing peptides.
Each of the HLA class I or class II peptide epitopes set out in the Tables herein are deemed singly to be an inventive aspect of this application. Further, it is also an inventive aspect of this application that each peptide epitope may be used in combination with any other peptide epitope.
IV.E. Enhancing Population Coverage of the Vaccine
Vaccines that have broad population coverage are preferred because they are more commercially viable and generally applicable to the most people. Broad population coverage can be obtained using the peptides of the invention (and nucleic acid compositions that encode such peptides) through selecting peptide epitopes that bind to HLA alleles which, when considered in total, are present in most of the population. Table XXI lists the overall frequencies of the HLA class I supertypes in various ethnicities (Table XXIa) and the combined population coverage achieved by the A2-, A3-, and B7-supertypes (Table XXIB). The A2-, A3-, and B7 supertypes are each present on the average of over 40% in each of these five major ethnic groups. Coverage in excess of 80% is achieved with a combination of these supermotifs. These results suggest that effective and non-ethnically biased population coverage is achieved upon use of a limited number of cross-reactive peptides. Although the population coverage reached with these three main peptide specificities is high, coverage can be expanded to reach 95% population coverage and above, and more easily achieve truly multispecific responses upon use of additional supermotif or allele-specific motif bearing peptides.
The B44-, A1-, and A24-supertypes are each present, on average, in a range from 25% to 40% in these major ethnic populations (Table XXIa). While less prevalent overall, the B27-, B58-, and B62 supertypes are each present with a frequency >25% in at least one major ethnic group (Table XXIa). Table XXIB summarizes the estimated prevalence of combinations of HLA supertypes that have been identified in five major ethnic groups. The incremental coverage obtained by the inclusion of A1, A24-, and B44-supertypes to the A2, A3, and B7 coverage and coverage obtained with all of the supertypes described herein, is shown.
The data presented herein, together with the previous definition of the A2-, A3-, and B7-supertypes, indicates that all antigens, with the possible exception of A29, B8, and B46, can be classified into a total of nine HLA supertypes. By including epitopes from the six most frequent supertypes, an average population coverage of 99% is obtained for five major ethnic groups.
IV.F. Immune Response-Stimulating Peptide Analogs
In general, CTL and HTL responses are not directed against all possible epitopes. Rather, they are restricted to a few “immunodominant” determinants (Zinkemagel, et al., Adv. Immunol. 27:5159, 1979; Bennink, et al., J. Exp. Med. 168:19351939, 1988; Rawle, et al., J. Immunol. 146:3977-3984, 1991). It has been recognized that immunodominance (Benacerraf, et al., Science 175:273-279, 1972) could be explained by either the ability of a given epitope to selectively bind a particular HILA protein (determinant selection theory) (Vitiello, et al., J. Immunol. 131:1635, 1983); Rosenthal, et al., Nature 267:156-158, 1977), or to be selectively recognized by the existing TCR (T cell receptor) specificities (repertoire theory) (Klein, J., IMMUNOLOGY, THE SCIENCE OF SELFNONSELF DISCRIMINATION, John Wiley & Sons, New York, pp. 270-310, 1982). It has been demonstrated that additional factors, mostly linked to processing events, can also play a key role in dictating, beyond strict immunogenicity, which of the many potential determinants will be presented as immunodominant (Sercarz, et al., Annu. Rev. Immunol. 11:729-766, 1993).
The concept of dominance and subdominance is relevant to immunotherapy of both infectious diseases and cancer. For example, in the course of chronic viral disease, recruitment of subdominant epitopes can be important for successful clearance of the infection, especially if dominant CTL or HTL specificities have been inactivated by functional tolerance, suppression, mutation of viruses and other mechanisms (Franco, et al., Curr. Opin. Immunol. 7:524-531, 1995). In the case of cancer and tumor antigens, CTLs recognizing at least some of the highest binding affinity peptides might be functionally inactivated. Lower binding affinity peptides are preferentially recognized at these times, and may therefore be preferred in therapeutic or prophylactic anti-cancer vaccines.
In particular, it has been noted that a significant number of epitopes derived from known non-viral tumor associated antigens (TAA) bind HLA class I with intermediate affinity (IC50 in the 50-500 nM range). For example, it has been found that 8 of 15 known TAA peptides recognized by tumor infiltrating lymphocytes (TIL) or CTL bound in the 50-500 nM range. (These data are in contrast with estimates that 90% of known viral antigens were bound by HLA class I molecules with IC50 of 50 nM or less, while only approximately 10% bound in the 50-500 nM range (Sette, et al., J. Immunol., 153:558-5592, 1994). In the cancer setting this phenomenon is probably due to elimination or functional inhibition of the CTL recognizing several of the highest binding peptides, presumably because of T cell tolerization events.
Without intending to be bound by theory, it is believed that because T cells to dominant epitopes may have been clonally deleted, selecting subdominant epitopes may allow existing T cells to be recruited, which will then lead to a therapeutic or prophylactic response. However, the binding of HLA molecules to subdominant epitopes is often less vigorous than to dominant ones. Accordingly, there is a need to be able to modulate the binding affinity of particular immunogenic epitopes for one or more HLA molecules, and thereby to modulate the immune response elicited by the peptide, for example to prepare analog peptides which elicit a more vigorous response. This ability would greatly enhance the usefulness of peptide epitope-based vaccines and therapeutic agents.
Although peptides with suitable cross-reactivity among all alleles of a superfamily are identified by the screening procedures described above, cross-reactivity is not always as complete as possible, and in certain cases procedures to increase cross-reactivity of peptides can be useful; moreover, such procedures can also be used to modify other properties of the peptides such as binding affinity or peptide stability. Having established the general rules that govern cross-reactivity of peptides for HLA alleles within a given motif or supermotif, modification (i.e., analoging) of the structure of peptides of particular interest in order to achieve broader (or otherwise modified) HLA binding capacity can be performed. More specifically, peptides which exhibit the broadest cross-reactivity patterns, can be produced in accordance with the teachings herein. The present concepts related to analog generation are set forth in greater detail in co-pending U.S. Ser. No. 09/226,775 filed Jan. 6, 1999.
In brief, the strategy employed utilizes the motifs or supermotifs which correlate with binding to certain HLA molecules. The motifs or supermotifs are defined by having primary anchors, and in many cases secondary anchors. Analog peptides can be created by substituting amino acid residues at primary anchor, secondary anchor, or at primary and secondary anchor positions. Generally, analogs are made for peptides that already bear a motif or supermotif. Preferred secondary anchor residues of supermotifs and motifs that have been defined for HLA class I and class II binding peptides are shown in Tables II and III, respectively.
For a number of the motifs or supermotifs in accordance with the invention, residues are defined which are deleterious to binding to allele-specific HLA molecules or members of HLA supertypes that bind the respective motif or supermotif (Tables II and E). Accordingly, removal of such residues that are detrimental to binding can be performed in accordance with the present invention. For example, in the case of the A3 supertype, when all peptides that have such deleterious residues are removed from the population of peptides used in the analysis, the incidence of cross-reactivity increased from 22% to 37% (see, e.g., Sidney, J. et al., Hu. Immunol. 45:79, 1996). Thus, one strategy to improve the cross-reactivity of peptides within a given supermotif is simply to delete one or more of the deleterious residues present within a peptide and substitute a small “neutral” residue such as Ala (that may not influence T cell recognition of the peptide). An enhanced likelihood of cross-reactivity is expected if, together with elimination of detrimental residues within a peptide, “preferred” residues associated with high affinity binding to an allele-specific HLA molecule or to multiple HLA molecules within a superfamily are inserted.
To ensure that an analog peptide, when used as a vaccine, actually elicits a CTL response to the native epitope in vivo (or, in the case of class II epitopes, elicits helper T cells that cross-react with the wild type peptides), the analog peptide may be used to immunize T cells in vitro from individuals of the appropriate HLA allele. Thereafter, the immunized cells' capacity to induce lysis of wild type peptide sensitized target cells is evaluated. It will be desirable to use as antigen presenting cells, cells that have been either infected, or transfected with the appropriate genes, or, in the case of class II epitopes only, cells that have been pulsed with whole protein antigens, to establish whether endogenously produced antigen is also recognized by the relevant T cells.
Another embodiment of the invention is to create analogs of weak binding peptides, to thereby ensure adequate numbers of cross-reactive cellular binders. Class I binding peptides exhibiting binding affinities of 500-5000 nM, and carrying an acceptable but suboptimal primary anchor residue at one or both positions can be “fixed” by substituting preferred anchor residues in accordance with the respective supertype. The analog peptides can then be tested for crossbinding activity.
Another embodiment for generating effective peptide analogs involves the substitution of residues that have an adverse impact on peptide stability or solubility in, e.g., a liquid environment. This substitution may occur at any position of the peptide epitope. For example, a cysteine (C) can be substituted out in favor of α-amino butyric acid. Due to its chemical nature, cysteine has the propensity to form disulfide bridges and sufficiently alter the peptide structurally so as to reduce binding capacity. Substituting α-amino butyric acid for C not only alleviates this problem, but actually improves binding and crossbinding capability in certain instances (see, e.g., the review by Sette et al., In: Persistent Viral Infections, Eds. R. Ahmed and I. Chen, John Wiley & Sons, England, 1999). Substitution of cysteine with α-amino butyric acid may occur at any residue of a peptide epitope, i.e. at either anchor or non-anchor positions.
IV.G. Computer Screening of Protein Sequences from Disease-Related Antigens for Supermotif- or Motif-Bearing Peptides
In order to identify supermotif- or motif-bearing epitopes in a target antigen, a native protein sequence, e.g., a tumor-associated antigen, or sequences from an infectious organism, or a donor tissue for transplantation, is screened using a means for computing, such as an intellectual calculation or a computer, to determine the presence of a supermotif or motif within the sequence. The information obtained from the analysis of native peptide can be used directly to evaluate the status of the native peptide or may be utilized subsequently to generate the peptide epitope.
Computer programs that allow the rapid screening of protein sequences for the occurrence of the subject supermotifs or motifs are encompassed by the present invention; as are programs that permit the generation of analog peptides. These programs are implemented to analyze any identified amino acid sequence or operate on an unknown sequence and simultaneously determine the sequence and identify motif-bearing epitopes thereof; analogs can be simultaneously determined as well. Generally, the identified sequences will be from a pathogenic organism or a tumor-associated peptide. For example, the target molecules considered herein include, without limitation, the gag, pol, env, nef, rev, tat, vif, vpr, and vpu proteins of HIV.
In cases where the sequence of multiple variants of the same target protein are available, potential peptide epitopes can also be selected on the basis of their conservancy. For example, a criterion for conservancy may define that the entire sequence of an HLA class I binding peptide or the entire 9-mer core of a class II binding peptide, be conserved in a designated percentage, of the sequences evaluated for a specific protein antigen.
Because HIV rapidly mutates thereby resulting in the generation of virus strains that have divergent amino acid sequences, an alternative method of selecting epitopes for inclusion in a vaccine composition is employed herein. In order to target a broad population that may be infected with a number of different strains, it is preferable to include in vaccine compositions epitopes that are representative of HIV antigen sequences from different HIV strains. For example, by selecting 5 epitopes from the same region, each of which is 20% conserved among HIV strains, the combination of the epitopes achieves 100% coverage of that region. As appreciated y those in the art, lower or higher degress of conservancy, such as the 15% conservancy used for identification of the epitopes set out in Tables VII-XX, can be employed as appropriate for a given antigenic target.
It is important that the selection criteria utilized for prediction of peptide binding are as accurate as possible, to correlate most efficiently with actual binding. Prediction of peptides that bind, for example, to HLA-A*0201, on the basis of the presence of the appropriate primary anchors, is positive at about a 30% rate (see, e.g., Ruppert, J. et al. Cell 74:929, 1993). However, by extensively analyzing peptide-HLA binding data disclosed herein, data in related patent applications, and data in the art, the present inventors have developed a number of allele-specific polynomial algorithms that dramatically increase the predictive value over identification on the basis of the presence of primary anchor residues alone. These algorithms take into account not only the presence or absence of primary anchors, but also consider the positive or deleterious presence of secondary anchor residues (to account for the impact of different amino acids at different positions). The algorithms are essentially based on the premise that the overall affinity (or ΔG) of peptide-HLA interactions can be approximated as a linear polynomial function of the type:
ΔG=a1i×a2i×a3i . . . ×ani
where aji is a coefficient that represents the effect of the presence of a given amino acid (i) at a given position (i) along the sequence of a peptide of n amino acids. An important assumption of this method is that the effects at each position are essentially independent of each other. This assumption is justified by studies that demonstrated that peptides are bound to HLA molecules and recognized by T cells in essentially an extended conformation. Derivation of specific algorithm coefficients has been described, for example, in Gulukota, K. et al., J. Mol. Biol. 267:1258, 1997.
Additional methods to identify preferred peptide sequences, which also make use of specific motifs, include the use of neural networks and molecular modeling programs (see, e.g., Milik et al., Nature Biotechnology 16:753, 1998; Altuvia et al., Hum. Immunol. 58:1, 1997; Altuvia et al, J. Mol. Biol. 249:244, 1995; Buus, S. Curr. Opin. Immunol. 11:209-213, 1999; Brusic, V. et al., Bioinformatics 14:121-130, 1998; Parker et al., J. Immunol. 152:163, 1993; Meister et al., Vaccine 13:581, 1995; Hammer et al., J. Exp. Med. 180:2353, 1994; Sturniolo et al., Nature Biotechnol. 17:555 1999).
For example, it has been shown that in sets of A*0201 motif-bearing peptides containing at least one preferred secondary anchor residue while avoiding the presence of any deleterious secondary anchor residues, 69% of the peptides will bind A*0201 with an IC50 less than 500 nM (Ruppert, J. et al. Cell 74:929, 1993). These algorithms are also flexible in that cut-off scores may be adjusted to select sets of peptides with greater or lower predicted binding properties, as desired.
In utilizing computer screening to identify peptide epitopes, a protein sequence or translated sequence may be analyzed using software developed to search for motifs, for example the “FINDPATTERNS' program (Devereux, et al. Nucl. Acids Res. 12:387-395, 1984) or Motif Search 1.4 software program (D. Brown, San Diego, Calif.) to identify potential peptide sequences containing appropriate HLA binding motifs. The identified peptides can be scored using customized polynomial algorithms to predict their capacity to bind specific HLA class I or class II alleles. As appreciated by one of ordinary skill in the art, a large array of computer programming software and hardware options are available in the relevant art which can be employed to implement the motifs of the invention in order to evaluate (e.g., without limitation, to identify epitopes, identify epitope concentration per peptide length, or to generate analogs) known or unknown peptide sequences.
In accordance with the procedures described above, HIV peptide epitopes and analogs thereof that are able to bind HLA supertype groups or allele-specific HLA molecules have been identified (Tables VII-XX).
IV.H. Preparation of Peptide Epitopes
Peptides in accordance with the invention can be prepared synthetically, by recombinant DNA technology or chemical synthesis, or from natural sources such as native tumors or pathogenic organisms. Peptide epitopes may be synthesized individually or as polyepitopic peptides. Although the peptide will preferably be substantially free of other naturally occurring host cell proteins and fragments thereof, in some embodiments the peptides may be synthetically conjugated to native fragments or particles.
The peptides in accordance with the invention can be a variety of lengths, and either in their neutral (uncharged) forms or in forms which are salts. The peptides in accordance with the invention are either free of modifications such as glycosylation, side chain oxidation, or phosphorylation; or they contain these modifications, subject to the condition that modifications do not destroy the biological activity of the peptides as described herein.
Desirably, the peptide epitope will be as small as possible while still maintaining substantially all of the immunologic activity of the native protein. When possible, it may be desirable to optimize HLA class I binding peptide epitopes of the invention to a length of about 8 to about 13 amino acid residues, preferably 9 to 10. HLA class II binding peptide epitopes may be optimized to a length of about 6 to about 30 amino acids in length, preferably to between about 13 and about 20 residues. Preferably, the peptide epitopes are commensurate in size with endogenously processed pathogen-derived peptides or tumor cell peptides that are bound to the relevant HLA molecules.
The identification and preparation of peptides of other lengths can also be carried out using the techniques described herein. Moreover, it is preferred to identify native peptide regions that contain a high concentration of class I and/or class II epitopes. Such a sequence is generally selected on the basis that it contains the greatest number of epitopes per amino acid length. It is to be appreciated that epitopes can be present in a frame-shifted manner, e.g. a 10 amino acid long peptide could contain two 9 amino acid long epitopes and one 10 amino acid long epitope; upon intracellular processing, each epitope can be exposed and bound by an HLA molecule upon administration of such a peptide. This larger, preferably multi-epitopic, peptide can be generated synthetically, recombinantly, or via cleavage from the native source.
The peptides of the invention can be prepared in a wide variety of ways. For the preferred relatively short size, the peptides can be synthesized in solution or on a solid support in accordance with conventional techniques. Various automatic synthesizers are commercially available and can be used in accordance with known protocols. (See, for example, Stewart & Young, SOLID PHASE PEPTIDE SYNTHESIS, 2D. ED, Pierce Chemical Co., 1984). Further, individual peptide epitopes can be joined using chemical ligation to produce larger peptides that are still within the bounds of the invention.
Alternatively, recombinant DNA technology can be employed wherein a nucleotide sequence which encodes an immunogenic peptide of interest is inserted into an expression vector, transformed or transfected into an appropriate host cell and cultivated under conditions suitable for expression. These procedures are generally known in the art, as described generally in Sambrook et al., MOLECULAR CLONING, A LABORATORY MANUAL, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (1989). Thus, recombinant polypeptides which comprise one or more peptide sequences of the invention can be used to present the appropriate T cell epitope.
The nucleotide coding sequence for peptide epitopes of the preferred lengths contemplated herein can be synthesized by chemical techniques, for example, the phosphotriester method of Matteucci, et al., J. Am. Chem. Soc. 103:3185 (1981). Peptide analogs can be made simply by substituting the appropriate and desired nucleic acid base(s) for those that encode the native peptide sequence; exemplary nucleic acid substitutions are those that encode an amino acid defined by the motifs/supermotifs herein. The coding sequence can then be provided with appropriate linkers and ligated into expression vectors commonly available in the art, and the vectors used to transform suitable hosts to produce the desired fusion protein. A number of such vectors and suitable host systems are now available. For expression of the fusion proteins, the coding sequence will be provided with operably linked start and stop codons, promoter and terminator regions and usually a replication system to provide an expression vector for expression in the desired cellular host. For example, promoter sequences compatible with bacterial hosts are provided in plasmids containing convenient restriction sites for insertion of the desired coding sequence. The resulting expression vectors are transformed into suitable bacterial hosts. Of course, yeast, insect or mammalian cell hosts may also be used, employing suitable vectors and control sequences.
IV.I. Assays to Detect T-Cell Responses
Once HLA binding peptides are identified, they can be tested for the ability to elicit a T-cell response. The preparation and evaluation of motif-bearing peptides are described in PCT publications WO 94/20127 and WO 94/03205. Briefly, peptides comprising epitopes from a particular antigen are synthesized and tested for their ability to bind to the appropriate HLA proteins. These assays may involve evaluating the binding of a peptide of the invention to purified HLA class I molecules in relation to the binding of a radioiodinated reference peptide. Alternatively, cells expressing empty class I molecules (i.e. lacking peptide therein) may be evaluated for peptide binding by immunofluorescent staining and flow microfluorimetry. Other assays that may be used to evaluate peptide binding include peptide-dependent class I assembly assays and/or the inhibition of CTL recognition by peptide competition. Those peptides that bind to the class I molecule, typically with an affinity of 500 nM or less, are further evaluated for their ability to serve as targets for CTLs derived from infected or immunized individuals, as well as for their capacity to induce primary in vitro or in vivo CTL responses that can give rise to CTL populations capable of reacting with selected target cells associated with a disease. Corresponding assays are used for evaluation of HLA class II binding peptides. HLA class II motif-bearing peptides that are shown to bind, typically at an affinity of 1000 nM or less, are further evaluated for the ability to stimulate HTL responses.
Conventional assays utilized to detect T cell responses include proliferation assays, lymphokine secretion assays, direct cytotoxicity assays, and limiting dilution assays. For example, antigen-presenting cells that have been incubated with a peptide can be assayed for the ability to induce CTL responses in responder cell populations. Antigen-presenting cells can be normal cells such as peripheral blood mononuclear cells or dendritic cells. Alternatively, mutant non-human mammalian cell lines that are deficient in their ability to load class I molecules with internally processed peptides and that have been transfected with the appropriate human class I gene, may be used to test for the capacity of the peptide to induce in vitro primary CTL responses.
Peripheral blood mononuclear cells (PBMCs) may be used as the responder cell source of CTL precursors. The appropriate antigen-presenting cells are incubated with peptide, after which the peptide-loaded antigen-presenting cells are then incubated with the responder cell population under optimized culture conditions. Positive CTL activation can be determined by assaying the culture for the presence of CTLs that kill radio-labeled target cells, both specific peptide-pulsed targets as well as target cells expressing endogenously processed forms of the antigen from which the peptide sequence was derived.
More recently, a method has been devised which allows direct quantification of antigen-specific T cells by staining with Fluorescein-labelled HLA tetrameric complexes (Altman, J. D. et al., Proc. Natl. Acad. Sci. USA 90:10330, 1993; Altman, J. D. et al., Science 274:94, 1996). Other relatively recent technical developments include staining for intracellular lymphokines, and interferon release assays or ELISPOT assays. Tetramer staining, intracellular lymphokine staining and ELISPOT assays all appear to be at least 10-fold more sensitive than more conventional assays (Lalvani, A. et al., J. Exp. Med. 186:859, 1997; Dunbar, P. R. et al., Curr. Biol. 8:413, 1998; Murali-Krishna, K. et al., Immunity 8:177, 1998).
HTL activation may also be assessed using such techniques known to those in the art such as T cell proliferation and secretion of lymphokines, e.g. IL-2 (see, e.g. Alexander et al., Immunity 1:751-761, 1994).
Alternatively, immunization of HLA transgenic mice can be used to determine immunogenicity of peptide epitopes. Several transgenic mouse models including mice with human A2.1, A11 (which can additionally be used to analyze HLA-A3 epitopes), and B7 alleles have been characterized and others (e.g., transgenic mice for HLA-A1 and A24) are being developed. HLA-DR1 and HLA-DR3 mouse models have also been developed. Additional transgenic mouse models with other HLA alleles may be generated as necessary. Mice may be immunized with peptides emulsified in Incomplete Freund's Adjuvant and the resulting T cells tested for their capacity to recognize peptide-pulsed target cells and target cells transfected with appropriate genes. CTL responses may be analyzed using cytotoxicity assays described above. Similarly, HTL responses may be analyzed using such assays as T cell proliferation or secretion of lymphokines.
Exemplary immunogenic peptide epitopes are set out in Table XXIII.
IV.J. Use of Peptide Epitopes as Diagnostic Agents and for Evaluating Immune Responses
HLA class I and class II binding peptides as described herein can be used, in one embodiment of the invention, as reagents to evaluate an immune response. The immune response to be evaluated may be induced by using as an immunogen any agent that may result in the production of antigen-specific CTLs or HTLs that recognize and bind to the peptide epitope(s) to be employed as the reagent. The peptide reagent need not be used as the immunogen. Assay systems that may be used for such an analysis include relatively recent technical developments such as tetramers, staining for intracellular lymphokines and interferon release assays, or ELISPOT assays.
For example, a peptide of the invention may be used in a tetramer staining assay to assess peripheral blood mononuclear cells for the presence of antigen-specific CTLs following exposure to a pathogen or immunogen. The HLA-tetrameric complex is used to directly visualize antigen-specific CTLs (see, e.g., Ogg et al., Science 279:2103-2106, 1998; and Altman et al., Science 174:94-96, 1996) and determine the frequency of the antigen-specific CTL population in a sample of peripheral blood mononuclear cells. A tetramer reagent using a peptide of the invention may be generated as follows: A peptide that binds to an HLA molecule is refolded in the presence of the corresponding HLA heavy chain and β2-microglobulin to generate a trimolecular complex. The complex is biotinylated at the carboxyl terminal end of the heavy chain at a site that was previously engineered into the protein. Tetramer formation is then induced by the addition of streptavidin. By means of fluorescently labeled streptavidin, the tetramer can be used to stain antigen-specific cells. The cells may then be identified, for example, by flow cytometry. Such an analysis may be used for diagnostic or prognostic purposes.
Peptides of the invention may also be used as reagents to evaluate immune recall responses. (see, e.g., Bertoni et al., J. Clin. Invest. 100:503-513, 1997 and Penna et al., J. Exp. Med. 174:1565-1570, 1991.) For example, patient PBMC samples from individuals infected with HIV may be analyzed for the presence of antigen-specific CTLs or HTLs using specific peptides. A blood sample containing mononuclear cells may be evaluated by cultivating the PBMCs and stimulating the cells with a peptide of the invention. After an appropriate cultivation period, the expanded cell population may be analyzed, for example, for CTL or for HTL activity.
The peptides may also be used as reagents to evaluate the efficacy of a vaccine. PBMCs obtained from a patient vaccinated with an immunogen may be analyzed using, for example, either of the methods described above. The patient is HLA typed, and peptide epitope reagents that recognize the allele-specific molecules present in that patient are selected for the analysis. The immunogenicity of the vaccine is indicated by the presence of HIV epitope-specific CTLs and/or HTLs in the PBMC sample.
The peptides of the invention may also be used to make antibodies, using techniques well known in the art (see, e.g. CURRENTPROTOCOLS IN IMMUNOLOGY, Wiley/Greene, NY; and Antibodies A Laboratory Manual Harlow, Harlow and Lane, Cold Spring Harbor Laboratory Press, 1989), which may be useful as reagents to diagnose HIV infection. Such antibodies include those that recognize a peptide in the context of an HLA molecule, i.e., antibodies that bind to a peptide-MHC complex.
IV.K. Vaccine Compositions
Vaccines that contain an immunogenically effective amount of one or more peptides as described herein are a further embodiment of the invention. Once appropriately immunogenic epitopes have been defined, they can be delivered by various means, herein referred to as “vaccine” compositions. Such vaccine compositions can include, for example, lipopeptides (e.g., Vitiello, A. et al., J. Clin. Invest. 95:341, 1995), peptide compositions encapsulated in poly(DL-lactide-co-glycolide) (“PLG”) microspheres (see, e.g., Eldridge, et al., Molec. Immunol. 28:287-294, 1991: Alonso et al., Vaccine 12:299-306, 1994; Jones et al., Vaccine 13:675-681, 1995), peptide compositions contained in immune stimulating complexes (ISCOMS) (see, e.g., Takahashi et al., Nature 344:873-875, 1990; Hu et al., Clin Exp Immunol. 113:235-243, 1998), multiple antigen peptide systems (MAPs) (see e.g., Tam, J. P., Proc. Natl. Acad. Sci. U.S.A. 85:5409-5413, 1988; Tam, J. P., J. Immunol. Methods 196:17-32, 1996), viral delivery vectors (Perkus, M. E. et al., In: Concepts in vaccine development, Kaufmann, S. H. E., ed., p. 379, 1996; Chakrabarti, S. et al., Nature 320:535, 1986; Hu, S. L. et al., Nature 320:537, 1986; Kieny, M.-P. et al., AIDS Bio/Technology 4:790, 1986; Top, F. H. et al., J. Infect. Dis. 124:148, 1971; Chanda, P. K. et al., Virology 175:535, 1990), particles of viral or synthetic origin (e.g., Kofler, N. et al., J. Immunol. Methods. 192:25, 1996; Eldridge, J. H. et al., Sem. Hematol. 30:16, 1993; Falo, L. D., Jr. et al., Nature Med. 7:649, 1995), adjuvants (Warren, H. S., Vogel, F. R., and Chedid, L. A. Annu. Rev. Immunol. 4:369, 1986; Gupta, R. K. et al., Vaccine 11:293, 1993), liposomes (Reddy, R. et al., J. Immunol. 148:1585, 1992; Rock, K. L., Immunol. Today 17:131, 1996), or, naked or particle absorbed cDNA (Ulmer, J. B. et al., Science 259:1745, 1993; Robinson, H. L., Hunt, L. A., and Webster, R. G., Vaccine 11:957, 1993; Shiver, J. W. et al., In: Concepts in vaccine development, Kaufmann, S. H. E., ed., p. 423, 1996; Cease, K. B., and Berzofsky, J. A., Annu. Rev. Immunol. 12:923, 1994 and Eldridge, J. H. et al., Sem. Hematol. 30:16, 1993). Toxin-targeted delivery technologies, also known as receptor mediated targeting, such as those of Avant Immunotherapeutics, Inc. (Needham, Mass.) may also be used.
Furthermore, vaccines in accordance with the invention encompass compositions of one or more of the claimed peptide(s). The peptide(s) can be individually linked to its own carrier; alternatively, the peptide(s) can exist as a homopolymer or heteropolymer of active peptide units. Such a polymer has the advantage of increased immunological reaction and, where different peptide epitopes are used to make up the polymer, the additional ability to induce antibodies and/or CTLs that react with different antigenic determinants of the pathogenic organism or tumor-related peptide targeted for an immune response. The composition may be a naturally occurring region of an antigen or may be prepared, e.g., recombinantly or by chemical synthesis.
Furthermore, useful carriers that can be used with vaccines of the invention are well known in the art, and include, e.g., thyroglobulin, albumins such as human serum albumin, tetanus toxoid, polyamino acids such as poly L-lysine, poly L-glutamic acid, influenza, hepatitis B virus core protein, and the like. The vaccines can contain a physiologically tolerable (i.e., acceptable) diluent such as water, or saline, preferably phosphate buffered saline. The vaccines also typically include an adjuvant. Adjuvants such as incomplete Freund's adjuvant, aluminum phosphate, aluminum hydroxide, or alum are examples of materials well known in the art. Additionally, as disclosed herein, CTL responses can be primed by conjugating peptides of the invention to lipids, such as tripalmitoyl-S-glycerylcysteinlyseryl-serine (P3CSS).
As disclosed in greater detail herein, upon immunization with a peptide composition in accordance with the invention, via injection, aerosol, oral, transdermal, transmucosal, intrapleural, intrathecal, or other suitable routes, the immune system of the host responds to the vaccine by producing large amounts of CTLs and/or HTLs specific for the desired antigen. Consequently, the host becomes at least partially immune to later infection, or at least partially resistant to developing an ongoing chronic infection, or derives at least some therapeutic benefit when the antigen was tumor-associated.
In some instances it may be desirable to combine the class I peptide vaccines of the invention with vaccines which induce or facilitate neutralizing antibody responses to the target antigen of interest, particularly to viral envelope antigens. A preferred embodiment of such a composition comprises class I and class II epitopes in accordance with the invention. An alternative embodiment of such a composition comprises a class I and/or class II epitope in accordance with the invention, along with a PADRE™ (Epimmune, San Diego, Calif.) molecule (described, for example, in U.S. Pat. No. 5,736,142). Furthermore, any of these embodiments can be administered as a nucleic acid mediated modality.
The vaccine compositions of the invention may also be used in combination with antiviral drugs such as interferon-α.
For therapeutic or prophylactic immunization purposes, the peptides of the invention can also be expressed by viral or bacterial vectors. Examples of expression vectors include attenuated viral hosts, such as vaccinia or fowlpox. This approach involves the use of vaccinia virus, for example, as a vector to express nucleotide sequences that encode the peptides of the invention. Upon introduction into an acutely or chronically infected host or into a non-infected host, the recombinant vaccinia virus expresses the immunogenic peptide, and thereby elicits a host CTL and/or HTL response. Vaccinia vectors and methods useful in immunization protocols are described in, e.g., U.S. Pat. No. 4,722,848. Another vector is BCG (Bacille Calmette Guerin). BCG vectors are described in Stover et al., Nature 351:456-460 (1991). A wide variety of other vectors useful for therapeutic administration or immunization of the peptides of the invention, e.g. adeno and adeno-associated virus vectors, retroviral vectors, Salmonella typhi vectors, detoxified anthrax toxin vectors, and the like, will be apparent to those skilled in the art from the description herein.
Antigenic peptides are used to elicit a CTL and/or HTL response ex vivo, as well. The resulting CTL or HTL cells, can be used to treat chronic infections, or tumors in patients that do not respond to other conventional forms of therapy, or will not respond to a therapeutic vaccine peptide or nucleic acid in accordance with the invention. Ex vivo CTL or HTL responses to a particular antigen (infectious or tumor-associated antigen) are induced by incubating in tissue culture the patient's, or genetically compatible, CTL or HTL precursor cells together with a source of antigen-presenting cells (APC), such as dendritic cells, and the appropriate immunogenic peptide. After an appropriate incubation time (typically about 7-28 days), in which the precursor cells are activated and expanded into effector cells, the cells are infused back into the patient, where they will destroy (CTL) or facilitate destruction (HTL) of their specific target cell (an infected cell or a tumor cell). Transfected dendritic cells may also be used as antigen presenting cells. Alternatively, dendritic cells are transfected, e.g., with a minigene construct in accordance with the invention, in order to elicit immune responses. Minigenes will be discussed in greater detail in a following section.
Vaccine compositions may also be administered in vivo in combination with dendritic cell mobilization whereby loading of dendritic cells occurs in vivo.
DNA or RNA encoding one or more of the peptides of the invention can also be administered to a patient. This approach is described, for instance, in Wolff et. al., Science 247:1465 (1990) as well as U.S. Pat. Nos. 5,580,859; 5,589,466; 5,804,566; 5,739,118; 5,736,524; 5,679,647; WO 98/04720; and in more detail below. Examples of DNA-based delivery technologies include “naked DNA”, facilitated (bupivicaine, polymers, peptide-mediated) delivery, cationic lipid complexes, and particle-mediated (“gene gun”) or pressure-mediated delivery (see, e.g., U.S. Pat. No. 5,922,687).
Preferably, the following principles are utilized when selecting an array of epitopes for inclusion in a polyepitopic composition for use in a vaccine, or for selecting discrete epitopes to be included in a vaccine and/or to be encoded by nucleic acids such as a minigene. Exemplary epitopes that may be utilized in a vaccine to treat or prevent HIV infection are set out in Tables XXXVII and XXXVIII. It is preferred that each of the following principles are balanced in order to make the selection. The multiple epitopes to be incorporated in a given vaccine composition may be, but need not be, contiguous in sequence in the native antigen from which the epitopes are derived.
1.) Epitopes are selected which, upon administration, mimic immune responses that have been observed to be correlated with HIV clearance. For HLA Class I this includes 3-4 epitopes that come from at least one antigen of HIV. For HLA Class II a similar rationale is employed; again 3-4 epitopes are selected from at least one HIV antigen (see e.g., Rosenberg et al., Science 278:1447-1450).
2.) Epitopes are selected that have the requisite binding affinity established to be correlated with immunogenicity: for HLA Class I an IC50 of 500 nM or less, or for Class II an IC50 of 1000 nM or less.
3.) Sufficient supermotif bearing-peptides, or a sufficient array of allele-specific motif-bearing peptides, are selected to give broad population coverage. For example, it is preferable to have at least 80% population coverage. A Monte Carlo analysis, a statistical evaluation known in the art, can be employed to assess the breadth, or redundancy of, population coverage.
4.) When selecting epitopes from cancer-related antigens it is often preferred to select analogs because the patient may have developed tolerance to the native epitope. When selecting epitopes for infectious disease-related antigens it is preferable to select either native or analoged epitopes. Of particular relevance for infectious disease vaccines (but for cancer-related vaccines as well), are epitopes referred to as “nested epitopes.” Nested epitopes occur where at least two epitopes overlap in a given peptide sequence. A peptide comprising “transcendent nested epitopes” is a peptide that has both HLA class I and HLA class II epitopes in it.
When providing nested epitopes, it is preferable to provide a sequence that has the greatest number of epitopes per provided sequence. Preferably, one avoids providing a peptide that is any longer than the amino terminus of the amino terminal epitope and the carboxyl terminus of the carboxyl terminal epitope in the peptide. When providing a longer peptide sequence, such as a sequence comprising nested epitopes, it is important to screen the sequence in order to insure that it does not have pathological or other deleterious biological properties.
5.) When creating a minigene, as disclosed in greater detail in the following section, an objective is to generate the smallest peptide possible that encompasses the epitopes of interest. The principles employed are similar, if not the same as those employed when selecting a peptide comprising nested epitopes. Furthermore, upon determination of the nucleic acid sequence to be provided as a minigene, the peptide encoded thereby is analyzed to determine whether any “junctional epitopes” have been created. A junctional epitope is an actual binding epitope, as predicted, e.g., by motif analysis, that only exists because two discrete peptide sequences are encoded directly next to each other. Junctional epitopes are generally to be avoided because the recipient may generate an immune response to that non-native epitope. Of particular concern is a junctional epitope that is a “dominant epitope.” A dominant epitope may lead to such a zealous response that immune responses to other epitopes are diminished or suppressed.
IV.K.1. Minigene Vaccines
A growing body of experimental evidence demonstrates that a number of different approaches are available which allow simultaneous delivery of multiple epitopes. Nucleic acids encoding the peptides of the invention are a particularly useful embodiment of the invention. Epitopes for inclusion in a minigene are preferably selected according to the guidelines set forth in the previous section. A preferred means of administering nucleic acids encoding the peptides of the invention uses minigene constructs encoding a peptide comprising one or multiple epitopes of the invention. The use of multi-epitope minigenes is described below and in, e.g., co-pending application U.S. Ser. No. 09/311,784; Ishioka et al., J. Immunol. 162:3915-3925, 1999; An, L. and Whitton, J. L., J. Virol. 71:2292, 1997; Thomson, S. A. et al., J. Immunol. 157:822, 1996; Whitton, J. L. et al., J. Virol. 67:348, 1993; Hanke, R. et al., Vaccine 16:426, 1998. For example, a multi-epitope DNA plasmid encoding nine dominant HLA-A*0201- and A11-restricted epitopes derived from the polymerase, envelope, and core proteins of HBV and human immunodeficiency virus (HIV), the PADRE™ universal helper T cell (HTL) epitope, and an endoplasmic reticulum-translocating signal sequence was engineered. Immunization of HLA transgenic mice with this plasmid construct resulted in strong CTL induction responses against the nine epitopes tested, similar to those observed with a lipopeptide of known immunogenicity in humans, and significantly greater than immunization in oil-based adjuvants. Moreover, the immunogenicity of DNA-encoded epitopes in vivo correlated with the in vitro responses of specific CTL lines against target cells transfected with the DNA plasmid. Thus, these data show that the minigene served to both: 1.) generate a CTL response and 2.) that the induced CTLs recognized cells expressing the encoded epitopes. A similar approach may be used to develop minigenes encoding HIV epitopes.
For example, to create a DNA sequence encoding the selected epitopes (minigene) for expression in human cells, the amino acid sequences of the epitopes may be reverse translated. A human codon usage table can be used to guide the codon choice for each amino acid. These epitope-encoding DNA sequences may be directly adjoined, so that when translated, a continuous polypeptide sequence is created. To optimize expression and/or immunogenicity, additional elements can be incorporated into the minigene design. Examples of amino acid sequences that can be reverse translated and included in the minigene sequence include: HLA class I epitopes, HLA class II epitopes, a ubiquitination signal sequence, and/or an endoplasmic reticulum targeting signal. In addition, HLA presentation of CTL and HTL epitopes may be improved by including synthetic (e.g. poly-alanine) or naturally-occurring flanking sequences adjacent to the CTL or HTL epitope; these larger peptides comprising the epitope(s) are within the scope of the invention.
The minigene sequence may be converted to DNA by assembling oligonucleotides that encode the plus and minus strands of the minigene. Overlapping oligonucleotides (30-100 bases long) may be synthesized, phosphorylated, purified and annealed under appropriate conditions using well known techniques. The ends of the oligonucleotides can be joined, for example, using T4 DNA ligase. This synthetic minigene, encoding the epitope polypeptide, can then be cloned into a desired expression vector.
Standard regulatory sequences well known to those of skill in the art are preferably included in the vector to ensure expression in the target cells. Several vector elements are desirable: a promoter with a down-stream cloning site for minigene insertion; a polyadenylation signal for efficient transcription termination; an E. coli origin of replication; and an E. coli selectable marker (e.g. ampicillin or kanamycin resistance). Numerous promoters can be used for this purpose, e.g., the human cytomegalovirus (hCMV) promoter. See, e.g., U.S. Pat. Nos. 5,580,859 and 5,589,466 for other suitable promoter sequences.
Additional vector modifications may be desired to optimize minigene expression and immunogenicity. In some cases, introns are required for efficient gene expression, and one or more synthetic or naturally-occurring introns could be incorporated into the transcribed region of the minigene. The inclusion of mRNA stabilization sequences and sequences for replication in mammalian cells may also be considered for increasing minigene expression.
Once an expression vector is selected, the minigene is cloned into the polylinker region downstream of the promoter. This plasmid is transformed into an appropriate E. coli strain, and DNA is prepared using standard techniques. The orientation and DNA sequence of the minigene, as well as all other elements included in the vector, are confirmed using restriction mapping and DNA sequence analysis. Bacterial cells harboring the correct plasmid can be stored as a master cell bank and a working cell bank.
In addition, immunostimulatory sequences (ISSs or CpGs) appear to play a role in the immunogenicity of DNA vaccines. These sequences may be included in the vector, outside the minigene coding sequence, if desired to enhance immunogenicity.
In some embodiments, a bi-cistronic expression vector which allows production of both the minigene-encoded epitopes and a second protein (included to enhance or decrease immunogenicity) can be used. Examples of proteins or polypeptides that could beneficially enhance the immune response if co-expressed include cytokines (e.g., IL-2, IL-12, GM-CSF), cytokine-inducing molecules (e.g., LeIF), costimulatory molecules, or for HTL responses, pan-DR binding proteins (PADRE™, Epinimune, San Diego, Calif.). Helper (HTL) epitopes can be joined to intracellular targeting signals and expressed separately from expressed CTL epitopes; this allows direction of the HTL epitopes to a cell compartment different than that of the CTL epitopes. If required, this could facilitate more efficient entry of HTL epitopes into the HLA class II pathway, thereby improving HTL induction. In contrast to HTL or CTL induction, specifically decreasing the immune response by co-expression of immunosuppressive molecules (e.g. TGF-β) may be beneficial in certain diseases.
Therapeutic quantities of plasmid DNA can be produced for example, by fermentation in E. coli, followed by purification. Aliquots from the working cell bank are used to inoculate growth medium, and grown to saturation in shaker flasks or a bioreactor according to well known techniques. Plasmid DNA can be purified using standard bioseparation technologies such as solid phase anion-exchange resins supplied by QIAGEN, Inc. (Valencia, Calif.). If required, supercoiled DNA can be isolated from the open circular and linear forms using gel electrophoresis or other methods.
Purified plasmid DNA can be prepared for injection using a variety of formulations. The simplest of these is reconstitution of lyophilized DNA in sterile phosphate-buffer saline (PBS). This approach, known as “naked DNA,” is currently being used for intramuscular (IM) administration in clinical trials. To maximize the immunotherapeutic effects of minigene DNA vaccines, an alternative method for formulating purified plasmid DNA may be desirable. A variety of methods have been described, and new techniques may become available. Cationic lipids, glycolipids, and fusogenic liposomes can also be used in the formulation (see, e.g., as described by WO 93/24640; Mannino & Gould-Fogerite, BioTechniques 6(7): 682 (1988); U.S. Pat. No. 5,279,833; WO 91/06309; and Felgner, et al., Proc. Nat'l Acad. Sci. USA 84:7413 (1987). In addition, peptides and compounds referred to collectively as protective, interactive, non-condensing compounds (PINC) could also be complexed to purified plasmid DNA to influence variables such as stability, intramuscular dispersion, or trafficking to specific organs or cell types.
Target cell sensitization can be used as a functional assay for expression and HLA class I presentation of minigene-encoded CTL epitopes. For example, the plasmid DNA is introduced into a mammalian cell line that is suitable as a target for standard CTL chromium release assays. The transfection method used will be dependent on the final formulation. Electroporation can be used for “naked” DNA, whereas cationic lipids allow direct in vitro transfection. A plasmid expressing green fluorescent protein (GFP) can be co-transfected to allow enrichment of transfected cells using fluorescence activated cell sorting (FACS). These cells are then chromium-51 (51Cr) labeled and used as target cells for epitope-specific CTL lines; cytolysis, detected by 51Cr release, indicates both production of, and HLA presentation of, minigene-encoded CTL epitopes. Expression of HTL epitopes may be evaluated in an analogous manner using assays to assess HTL activity.
In vivo immunogenicity is a second approach for functional testing of minigene DNA formulations. Transgenic mice expressing appropriate human HLA proteins are immunized with the DNA product. The dose and route of administration are formulation dependent (e.g., IM for DNA in PBS, intraperitoneal (IP) for lipid-complexed DNA). Twenty-one days after immunization, splenocytes are harvested and restimulated for one week in the presence of peptides encoding each epitope being tested. Thereafter, for CTL effector cells, assays are conducted for cytolysis of peptide-loaded, 5Cr-labeled target cells using standard techniques. Lysis of target cells that were sensitized by HLA loaded with peptide epitopes, corresponding to minigene-encoded epitopes, demonstrates DNA vaccine function for in vivo induction of CTLs. Immunogenicity of HTL epitopes is evaluated in transgenic mice in an analogous manner.
Alternatively, the nucleic acids can be administered using ballistic delivery as described, for instance, in U.S. Pat. No. 5,204,253. Using this technique, particles comprised solely of DNA are administered. In a further alternative embodiment, DNA can be adhered to particles, such as gold particles.
IV.K2. Combinations of CTL Peptides with Helper Peptides
Vaccine compositions comprising the peptides of the present invention, or analogs thereof, which have immunostimulatory activity may be modified to provide desired attributes, such as improved serum half life, or to enhance immunogenicity.
For instance, the ability of a peptide to induce CTL activity can be enhanced by linking the peptide to a sequence which contains at least one epitope that is capable of inducing a T helper cell response. The use of T helper epitopes in conjunction with CTL epitopes to enhance immunogenicity is illustrated, for example, in the co-pending applications U.S. Ser. No. 08/820,360, U.S. Ser. No. 08/197,484, and U.S. Ser. No. 08/464,234.
Particularly preferred CTL epitope/HTL epitope conjugates are linked by a spacer molecule. The spacer is typically comprised of relatively small, neutral molecules, such as amino acids or amino acid mimetics, which are substantially uncharged under physiological conditions. The spacers are typically selected from, e.g., Ala, Gly, or other neutral spacers of nonpolar amino acids or neutral polar amino acids. It will be understood that the optionally present spacer need not be comprised of the same residues and thus may be a hetero- or homo-oligomer. When present, the spacer will usually be at least one or two residues, more usually three to six residues. Alternatively, the CTL peptide may be linked to the T helper peptide without a spacer.
The CTL peptide epitope may be linked to the T helper peptide epitope either directly or via a spacer either at the amino or carboxy terminus of the CTL peptide. The amino terminus of either the immunogenic peptide or the T helper peptide may be acylated. The HTL peptide epitopes used in the invention can be modified in the same manner as CTL peptides. For instance, they may be modified to include D-amino acids or be conjugated to other molecules such as lipids, proteins, sugars and the like.
In certain embodiments, the T helper peptide is one that is recognized by T helper cells present in the majority of the population. This can be accomplished by selecting amino acid sequences that bind to many, most, or all of the HLA class II molecules. These are known as “loosely HLA-restricted” or “promiscuous” T helper sequences. Examples of amino acid sequences that are promiscuous include sequences from antigens such as tetanus toxoid at positions 830-843 (QYIKANSKFIGITE), Plasmodium falciparum CS protein at positions 378-398 (DIEKKMAKMEKASSVFNVVNS), and Streptococcus 18 kD protein at positions 116 (GAVDSILGGVATYGAA). Other examples include peptides bearing a DR 1-4-7 supermotif, or either of the DR3 motifs.
Alternatively, it is possible to prepare synthetic peptides capable of stimulating T helper lymphocytes, in a loosely HLA-restricted fashion, using amino acid sequences not found in nature (see, e.g., PCT publication WO 95/07707). These synthetic compounds called Pan-DR-binding epitopes (e.g., PADRE™, Epimmune, Inc., San Diego, Calif.) are designed to most preferrably bind most HLA-DR (human HLA class II) molecules. For instance, a pan-DR-binding epitope peptide having the formula: aKXVWANTLKAAa, where “X” is either cyclohexylalanine, phenylalanine, or tyrosine, and a is either D-alanine or L-alanine, has been found to bind to most HLA-DR alleles, and to stimulate the response of T helper lymphocytes from most individuals, regardless of their BLA type. An alternative of a pan-DR binding epitope comprises all “L” natural amino acids and can be provided in the form of nucleic acids that encode the epitope.
HTL peptide epitopes can also be modified to alter their biological properties. For example, peptides comprising HTL epitopes can contain D-amino acids to increase their resistance to proteases and thus extend their serum half-life. Also, the epitope peptides of the invention can be conjugated to other molecules such as lipids, proteins or sugars, or any other synthetic compounds, to increase their biological activity. Specifically, the T helper peptide can be conjugated to one or more palmitic acid chains at either the amino or carboxyl termini.
In some embodiments it may be desirable to include in the pharmaceutical compositions of the invention at least one component which primes cytotoxic T lymphocytes. Lipids have been identified as agents capable of priming CTL in vivo against viral antigens. For example, palmitic acid residues can be attached to the ε-and α-amino groups of a lysine residue and then linked, e.g., via one or more linking residues such as Gly, Gly-Gly-, Ser, Ser-Ser, or the like, to an immunogenic peptide. The lipidated peptide can then be administered either directly in a micelle or particle, incorporated into a liposome, or emulsified in an adjuvant, e.g., incomplete Freund's adjuvant. In a preferred embodiment, a particularly effective immunogenic comprises palmitic acid attached to ε- and α-amino groups of Lys, which is attached via linkage, e.g., Ser-Ser, to the amino terminus of the immunogenic peptide.
As another example of lipid priming of CTL responses, E. coli lipoproteins, such as tripalmitoyl-S-glycerylcysteinlyseryl serine (P3CSS) can be used to prime virus specific CTL when covalently attached to an appropriate peptide. (See, e.g., Deres, et al., Nature 342:561, 1989). Peptides of the invention can be coupled to P3CSS, for example, and the lipopeptide administered to an individual to specifically prime a CTL response to the target antigen. Moreover, because the induction of neutralizing antibodies can also be primed with P3CSS-conjugated epitopes, two such compositions can be combined to more effectively elicit both humoral and cell-mediated responses to infection.
As noted herein, additional amino acids can be added to the termini of a peptide to provide for ease of linking peptides one to another, for coupling to a carrier support or larger peptide, for modifying the physical or chemical properties of the peptide or oligopeptide, or the like. Amino acids such as tyrosine, cysteine, lysine, glutamic or aspartic acid, or the like, can be introduced at the C- or N-terminus of the peptide or oligopeptide, particularly class I peptides. However, it is to be noted that modification at the carboxyl terminus of a CTL epitope may, in some cases, alter binding characteristics of the peptide. In addition, the peptide or oligopeptide sequences can differ from the natural sequence by being modified by terminal-NH2 acylation, e.g., by alkanoyl (C1-C20) or thioglycolyl acetylation, terminal-carboxylamidation, e.g. ammonia, methylamine, etc. In some instances these modifications may provide sites for linking to a support or other molecule.
IV.L. Administration of Vaccines for Therapeutic or Prophylactic Purposes
The peptides of the present invention and pharmaceutical and vaccine compositions of the invention are useful for administration to mammals, particularly humans, to treat and/or prevent HIV infection. Vaccine compositions containing the peptides of the invention are administered to a patient infected with HIV or to an individual susceptible to, or otherwise at risk for, HIV infection to elicit an immune response against HIV antigens and thus enhance the patient's own immune response capabilities. In therapeutic applications, peptide and/or nucleic acid compositions are administered to a patient in an amount sufficient to elicit an effective CTL and/or HTL response to the virus antigen and to cure or at least partially arrest or slow symptoms and/or complications. An amount adequate to accomplish this is defined as “therapeutically effective dose.” Amounts effective for this use will depend on, e.g., the particular composition administered, the manner of administration, the stage and severity of the disease being treated, the weight and general state of health of the patient, and the judgment of the prescribing physician.
The vaccine compositions of the invention may also be used purely as prophylactic agents. Generally the dosage for an initial prophylactic immunization generally occurs in a unit dosage range where the lower value is about 1, 5, 50, 500, or 1000 μg and the higher value is about 10,000; 20,000; 30,000; or 50,000 μg. Dosage values for a human typically range from about 500 μg to about 50,000 μg per 70 kilogram patient. This is followed by boosting dosages of between about 1.0 μg to about 50,000 μg of peptide administered at defined intervals from about four weeks to six months after the initial administration of vaccine. The immunogenicity of the vaccine may be assessed by measuring the specific activity of CTL and HTL obtained from a sample of the patient's blood.
As noted above, peptides comprising CTL and/or HTL epitopes of the invention induce immune responses when presented by HLA molecules and contacted with a CTL or HTL specific for an epitope comprised by the peptide. The manner in which the peptide is contacted with the CTL or HTL is not critical to the invention. For instance, the peptide can be contacted with the CTL or HTL either in vivo or in vitro. If the contacting occurs in vivo, the peptide itself can be administered to the patient, or other vehicles, e.g., DNA vectors encoding one or more peptides, viral vectors encoding the peptide(s), liposomes and the like, can be used, as described herein.
For pharmaceutical compositions, the immunogenic peptides of the invention, or DNA encoding them, are generally administered to an individual already infected with HIV. The peptides or DNA encoding them can be administered individually or as fusions of one or more peptide sequences. Those in the incubation phase or the acute phase of infection can be treated with the immunogenic peptides separately or in conjunction with other treatments, as appropriate.
For therapeutic use, administration should generally begin at the first diagnosis of HIV infection. This is followed by boosting doses until at least symptoms are substantially abated and for a period thereafter. In chronic infection, loading doses followed by boosting doses may be required.
Treatment of an infected individual with the compositions of the invention may hasten resolution of the infection in acutely infected individuals and prevent development of chronic infection. Where susceptible individuals are identified prior to or during infection, the composition can be targeted to them, thus minimizing the need for administration to a larger population.
The peptide or other compositions used for the treatment or prophylaxis of HIV infection can be used, e.g., in persons who have not manifested symptoms of disease but who act as a disease vector. In this context, it is generally important to provide an amount of the peptide epitope delivered by a mode of administration sufficient to effectively stimulate a cytotoxic T cell response; compositions which stimulate helper T cell responses can also be given in accordance with this embodiment of the invention.
The dosage for an initial therapeutic immunization generally occurs in a unit dosage range where the lower value is about 1, 5, 50, 500, or 1,000 μg and the higher value is about 10,000; 20,000; 30,000; or 50,000 μg. Dosage values for a human typically range from about 500 μg to about 50,000 μg per 70 kilogram patient. Boosting dosages of between about 1.0 μg to about 50,000 μg of peptide pursuant to a boosting regimen over weeks to months may be administered depending upon the patient's response and condition as determined by measuring the specific activity of CTL and HTL obtained from the patient's blood. The peptides and compositions of the present invention may be employed in serious disease states, that is, life-threatening or potentially life threatening situations. In such cases, as a result of the minimal amounts of extraneous substances and the relative nontoxic nature of the peptides in preferred compositions of the invention, it is possible and may be felt desirable by the treating physician to administer substantial excesses of these peptide compositions relative to these stated dosage amounts.
Thus, for treatment of chronic infection, a representative dose is in the range disclosed above, namely where the lower value is about 1, 5, 50, 500, or 1,000 μg and the higher value is about 10,000; 20,000; 30,000; or 50,000 μg, preferably from about 500 μg to about 50,000 μg per 70 kilogram patient. Initial doses followed by boosting doses at established intervals, e.g., from four weeks to six months, may be required, possibly for a prolonged period of time to effectively immunize an individual. In the case of chronic infection, administration should continue until at least clinical symptoms or laboratory tests indicate that the viral infection has been eliminated or substantially abated and for a period thereafter. The dosages, routes of administration, and dose schedules are adjusted in accordance with methodologies known in the art.
The pharmaceutical compositions for therapeutic treatment are intended for parenteral, topical, oral, intrathecal, or local administration. Preferably, the pharmaceutical compositions are administered parentally, e.g., intravenously, subcutaneously, intradermally, or intramuscularly. Thus, the invention provides compositions for parenteral administration which comprise a solution of the immunogenic peptides dissolved or suspended in an acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers may be used, e.g., water, buffered water, 0.8% saline, 0.3% glycine, hyaluronic acid and the like. These compositions may be sterilized by conventional, well known sterilization techniques, or may be sterile filtered. The resulting aqueous solutions may be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile solution prior to administration. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions, such as pH-adjusting and buffering agents, tonicity adjusting agents, wetting agents, preservatives, and the like, for example, sodium acetate, sodium lactate, sodium chloride, potassium chloride, calcium chloride, sorbitan monolaurate, triethanolamine oleate, etc.
The concentration of peptides of the invention in the pharmaceutical formulations can vary widely, i.e., from less than about 0.1%, usually at or at least about 2% to as much as 20% to 50% or more by weight, and will be selected primarily by fluid volumes, viscosities, etc., in accordance with the particular mode of administration selected.
A human unit dose form of the peptide composition is typically included in a pharmaceutical composition that comprises a human unit dose of an acceptable carrier, preferably an aqueous carrier, and is administered in a volume of fluid that is known by those of skill in the art to be used for administration of such compositions to humans (see, e.g., Remington's Pharmaceutical Sciences, 17th Edition, A. Gennaro, Editor, Mack Publishing Co., Easton, Pa., 1985).
The peptides of the invention may also be administered via liposomes, which serve to target the peptides to a particular tissue, such as lymphoid tissue, or to target selectively to infected cells, as well as to increase the half-life of the peptide composition. Liposomes include emulsions, foams, micelles, insoluble monolayers, liquid crystals, phospholipid dispersions, lamellar layers and the like. In these preparations, the peptide to be delivered is incorporated as part of a liposome, alone or in conjunction with a molecule which binds to a receptor prevalent among lymphoid cells, such as monoclonal antibodies which bind to the CD45 antigen, or with other therapeutic or immunogenic compositions. Thus, liposomes either filled or decorated with a desired peptide of the invention can be directed to the site of lymphoid cells, where the liposomes then deliver the peptide compositions. Liposomes for use in accordance with the invention are formed from standard vesicle-forming lipids, which generally include neutral and negatively charged phospholipids and a sterol, such as cholesterol. The selection of lipids is generally guided by consideration of, e.g., liposome size, acid liability and stability of the liposomes in the blood stream. A variety of methods are available for preparing liposomes, as described in, e.g., Szoka, et al., Ann. Rev. Biophys. Bioeng. 9:467 (1980), and U.S. Pat. Nos. 4,235,871, 4,501,728, 4,837,028, and 5,019,369.
For targeting cells of the immune system, a ligand to be incorporated into the liposome can include, e.g., antibodies or fragments thereof specific for cell surface determinants of the desired immune system cells. A liposome suspension containing a peptide may be administered intravenously, locally, topically, etc. in a dose which varies according to, inter alia, the manner of administration, the peptide being delivered, and the stage of the disease being treated.
For solid compositions, conventional nontoxic solid carriers may be used which include, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin, talcum, cellulose, glucose, sucrose, magnesium carbonate, and the like. For oral administration, a pharmaceutically acceptable nontoxic composition is formed by incorporating any of the normally employed excipients, such as those carriers previously listed, and generally 10-95% of active ingredient, that is, one or more peptides of the invention, and more preferably at a concentration of 25%-75%.
For aerosol administration, the immunogenic peptides are preferably supplied in finely divided form along with a surfactant and propellant. Typical percentages of peptides are 0.01%-20% by weight, preferably 1%-10%. The surfactant must, of course, be nontoxic, and preferably soluble in the propellant. Representative of such agents are the esters or partial esters of fatty acids containing from 6 to 22 carbon atoms, such as caproic, octanoic, lauric, palmitic, stearic, linoleic, linolenic, olesteric and oleic acids with an aliphatic polyhydric alcohol or its cyclic anhydride. Mixed esters, such as mixed or natural glycerides may be employed. The surfactant may constitute 0.1%-20% by weight of the composition, preferably 0.25-5%. The balance of the composition is ordinarily propellant. A carrier can also be included, as desired, as with, e.g., lecithin for intranasal delivery.
IV.M. Kits
The peptide and nucleic acid compositions of this invention can be provided in kit form together with instructions for vaccine administration. Typically the kit would include desired peptide compositions in a container, preferably in unit dosage form and instructions for administration. An alternative kit would include a minigene construct with desired nucleic acids of the invention in a container, preferably in unit dosage form together with instructions for administration. Lymphokines such as IL-2 or IL-12 may also be included in the kit. Other kit components that may also be desirable include, for example, a sterile syringe, booster dosages, and other desired excipients.
The invention will be described in greater detail by way of specific examples. The following examples are offered for illustrative purposes, and are not intended to limit the invention in any manner. Those of skill in the art will readily recognize a variety of non-critical parameters that can be changed or modified to yield alternative embodiments in accordance with the invention.
V. EXAMPLES
The following examples illustrate identification, selection, and use of immunogenic Class I and Class II peptide epitopes for inclusion in vaccine compositions.
Example 1
HLA Class I and Class II Binding Assays
The following example of peptide binding to HLA molecules demonstrates quantification of binding affinities of HLA class I and class II peptides. Binding assays can be performed with peptides that are either motif-bearing or not motif-bearing.
Epstein-Barr virus (EBV)-transformed homozygous cell lines, fibroblasts, CIR, or 721.22 transfectants were used as sources of HLA class I molecules. These cells were maintained in vitro by culture in RPMI 1640 medium supplemented with 2 mM L-glutamine (GIBCO, Grand Island, N.Y.), 50 μM 2-ME, 100 μg/ml of streptomycin, 100 U/ml of penicillin (Irvine Scientific) and 10% heat-inactivated FCS (Irvine Scientific, Santa Ana, Calif.). Cells were grown in 225-cm2 tissue culture flasks or, for large-scale cultures, in roller bottle apparatuses. The specific cell lines routinely used for purification of MHC class I and class II molecules are listed in Table XXIV.
Cell lysates were prepared and HLA molecules purified in accordance with disclosed protocols (Sidney et al., Current Protocols in Immunology 18.3.1 (1998); Sidney, et al., J. Immunol. 154:247 (1995); Sette, et al., Mol. Immunol. 31:813 (1994)). Briefly, cells were lysed at a concentration of 108 cells/ml in 50 mM Tris-HCl, pH 8.5, containing 1% Nonidet P-40 (Fluka Biochemika, Buchs, Switzerland), 150 mM NaCl, 5 mM EDTA, and 2 mM PMSF. Lysates were cleared of debris and nuclei by centrifugation at 15,000×g for 30 min.
HLA molecules were purified from lysates by affinity chromatography. Lysates prepared as above were passed twice through two pre-columns of inactivated Sepharose CL4-B and protein A-Sepharose. Next, the lysate was passed over a column of Sepharose CL-4B beads coupled to an appropriate antibody. The antibodies used for the extraction of HLA from cell lysates are listed in Table XXV. The anti-HLA column was then washed with 10-column volumes of 10 mM Tris-HCL, pH 8.0, in 1% NP-40, PBS, 2-column volumes of PBS, and 2-column volumes of PBS containing 0.4% n-octylglucoside. Finally, MHC molecules were eluted with 50M diethylamine in 0.15M NaCl containing 0.4% n-octylglucoside, pH 11.5. A 1/25 volume of 2.0M Tris, pH 6.8, was added to the eluate to reduce the pH to ˜8.0. Eluates were then be concentrated by centrifugation in Centriprep 30 concentrators at 2000 rpm (Amicon, Beverly, Mass.). Protein content was evaluated by a BCA protein assay (Pierce Chemical Co., Rockford, Ill.) and confirmed by SDS-PAGE.
A detailed description of the protocol utilized to measure the binding of peptides to Class I and Class II MHC has been published (Sette et al., Mol. Immunol. 31:813, 1994; Sidney et al., in Current Protocols in Immunology, Margulies, Ed., John Wiley & Sons, New York, Section 18.3, 1998). Briefly, purified MHC molecules (5 to 500 nM) were incubated with various unlabeled peptide inhibitors and 1-10 nM 125I-radio-labeled probe peptides for 48 h in PBS containing 0.05% Nonidet P-40 (NP40) (or 20% w/v digitonin for H-2 IA assays) in the presence of a protease inhibitor cocktail. The final concentrations of protease inhibitors (each from CalBioChem, La Jolla, Calif.) were 1 mM PMSF, 1.3 nM 1.10 phenanthroline, 73 μM pepstatin A, 8 mM EDTA, 6 mM N-ethylmaleimide (for Class II assays), and 200 μM N alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK). All assays were performed at pH 7.0 with the exception of DRB1*0301, which was performed at pH 4.5, and DRB1*1601 (DR2w21β1) and DRB4*0101 (DRw53), which were performed at pH 5.0. pH was adjusted as described elsewhere (see Sidney et al., in Current Protocols in Immunology, Margulies, Ed., John Wiley & Sons, New York, Section 18.3, 1998). Following incubation, MHC-peptide complexes were separated from free peptide by gel filtration on 7.8 mm×15 cm TSK200 columns (TosoHaas 16215, Montgomeryville, Pa.), eluted at 1.2 mls/min with PBS pH 6.5 containing 0.5% NP40 and 0.1% NaN3. Because the large size of the radiolabeled peptide used for the DRB1*1501 (DR2w2β1) assay makes separation of bound from unbound peaks more difficult under these conditions, all DRB1*1501 (DR2w2β1) assays were performed using a 7.8 mm×30 cm TSK2000 column eluted at 0.6 mls/min. The eluate from the TSK columns was passed through a Beckman 170 radioisotope detector, and radioactivity was plotted and integrated using a Hewlett-Packard 3396A integrator, and the fraction of peptide bound was determined. Radiolabeled peptides were iodinated using the chloramine-T method. Representative radiolabeled probe peptides utilized in each assay, and its assay specific IC50 nM, are summarized in Tables IV and V. Typically, in preliminary experiments, each MHC preparation was titered in the presence of fixed amounts of radio-labeled peptides to determine the concentration of HLA molecules necessary to bind 10-20% of the total radioactivity. All subsequent inhibition and direct binding assays were performed using these HLA concentrations.
Since under these conditions [label]<[HLA] and IC50>[HLA], the measured IC50 values are reasonable approximations of the true KD values. Peptide inhibitors are typically tested at concentrations ranging from 120 μg/ml to 1.2 ng/ml, and are tested in two to four completely independent experiments. To allow comparison of the data obtained in different experiments, a relative binding figure is calculated for each peptide by dividing the IC50 of a positive control for inhibition by the IC50 for each tested peptide (typically unlabeled versions of the radiolabeled probe peptide). For database purposes, and inter-experiment comparisons, relative binding values are compiled. These values can subsequently be converted back into IC50 nM values by dividing the IC50 nM of the positive controls for inhibition by the relative binding of the peptide of interest. This method of data compilation has proven to be the most accurate and consistent for comparing peptides that have been tested on different days, or with different lots of purified MHC.
Because the antibody used for HLA-DR purification (LB3.1) is α-chain specific, β1 molecules are not separated from β3 (and/or β4 and β5) molecules. The β1 specificity of the binding assay is obvious in the cases of DRB1*0101 (DR1), DRB1*0802 (DR8w2), and DRB1*0803 (DR8w3), where no P3 is expressed. It has also been demonstrated for DRB1*0301 (DR3) and DRB3*0101 (DR52a), DRB1*0401 (DR4w4), DRB1*0404 (DR4w14), DRB1*0405 (DR4w15), DRB1*1101 (DR5), DRB 1*1201 (DR5w12), DRB1*1302 (DR6w19) and DRB1*0701 (DR7). The problem of β chain specificity for DRB1*1501 (DR2w2p1), DRB5*0101 (DR2w2P2), DRB1*1601 (DR2w21β1), DRB5*0201 (DR51Dw21), and DRB4*0101 (DRw53) assays is circumvented by the use of fibroblasts. Development and validation of assays with regard to DRβ molecule specificity have been described previously (see, e.g., Southwood et al., J. Immunol. 160:3363-3373, 1998).
Binding assays as outlined above may be used to analyze supermotif and/or motif-bearing epitopes as, for example, described in Example 2.
Example 2
Identification of HLA Supermotif- and Motif-Bearing CTL Candidate Epitopes
Vaccine compositions of the invention may include multiple epitopes that comprise multiple HLA supermotifs or motifs to achieve broad population coverage. This example illustrates the identification of supermotif- and motif-bearing epitopes for the inclusion in such a vaccine composition. Calculation of population coverage was performed using the strategy described below.
Computer Searches and Algorthims for Identification of Supermotif and/or Motif-Bearing Epitopes
The searches performed to identify the motif-bearing peptide sequences in Examples 2 and 5 employed the protein sequence data from HIV-1 clade B virus strains that were available in the 1994 Los Alamos database.
Computer searches for epitopes bearing HLA Class I or Class II supermotifs or motifs were performed as follows. All translated HIV protein sequences were analyzed using a text string search software program, e.g., MotifSearch 1.4 (D. Brown, San Diego) to identify potential peptide sequences containing appropriate HLA binding motifs; alternative programs are readily produced in accordance with information in the art in view of the motif/supermotif disclosure herein. Furthermore, such calculations can be made mentally. Identified A2-, A3-, and DR-supermotif sequences were scored using polynomial algorithms to predict their capacity to bind to specific HLA-Class I or Class II molecules. These polynomial algorithms take into account both extended and refined motifs (that is, to account for the impact of different amino acids at different positions), and are essentially based on the premise that the overall affinity (or AG) of peptide-HLA molecule interactions can be approximated as a linear polynomial function of the type:
“ΔG”=a1i×a2i ×a3i . . . ×ani,
where aji is a coefficient which represents the effect of the presence of a given amino acid (i) at a given position (i) along the sequence of a peptide of n amino acids. The crucial assumption of this method is that the effects at each position are essentially independent of each other (i.e., independent binding of individual side-chains). When residue j occurs at position i in the peptide, it is assumed to contribute a constant amount ji to the free energy of binding of the peptide irrespective of the sequence of the rest of the peptide. This assumption is justified by studies from our laboratories that demonstrated that peptides are bound to MHC and recognized by T cells in essentially an extended conformation (data omitted herein).
The method of derivation of specific algorithm coefficients has been described in Gulukota et al., J. Mol. Biol. 267:1258-126, 1997; (see also Sidney et al., Human Immunol. 45:79-93, 1996; and Southwood et al., J. Immunol. 160:3363-3373, 1998). Briefly, for all i positions, anchor and non-anchor alike, the geometric mean of the average relative binding (ARB) of all peptides carrying j is calculated relative to the remainder of the group, and used as the estimate of ji. For Class II peptides, if multiple alignments are possible, only the highest scoring alignment is utilized, following an iterative procedure. To calculate an algorithm score of a given peptide in a test set, the ARB values corresponding to the sequence of the peptide are multiplied. If this product exceeds a chosen threshold, the peptide is predicted to bind. Appropriate thresholds are chosen as a function of the degree of stringency of prediction desired.
Selection of HLA-A2 Supertype Cross-Reactive Peptides
Complete protein sequences from nine HIV structural and regulatory proteins were aligned, then scanned, utilizing motif identification software, to identify conserved 9- and 10-mer sequences containing the HLA-A2-supermotif main anchor specificity. The analysis included all isolates in the 1994 Los Alamos database. The conservation criteria varied according to antigen: greater than 80% of clade B lates for gag, pol, env; greater than 70% for nef, rev, tat, vif, vpr; great than 60% for vpu.)
A total of 233 conserved, HLA-A2 supermotif-positive sequences were identified. The peptides corresponding to the sequences were then synthesized and tested for their capacity to bind purified HLA-A*0201 molecules in vitro (HLA-A*0201 is considered a prototype A2 supertype molecule). Thirty peptides bound A*0201 with IC50 values ≦500 nM; of these 30, 5 bound with high binding affinities (IC50 values ≦50 μM) and 25 bound with intermediate binding affinities, in the 50-500 nM range (Table XXVII).
The thirty A*0201-binding peptides were subsequently tested for the capacity to bind to additional A2-supertype molecules (A*0202, A*0203, A*0206, and A*6802). As shown in Table XXVII, 20 of the 30 peptides were found to be A2-supertype cross-reactive binders, binding at least 3 of the 5 A2-supertype alleles tested.
Selection of HLA-A3 Supermotif-Bearing Epitopes
The HIV protein sequences scanned above were also examined for the presence of peptides with the HLA-A3-supermotif primary anchors. A total of 353 conserved 9- or 10-mer motif-containing sequences were identified. The corresponding peptides were synthesized and tested for binding to HLA-A*0301 and HLA-A*1101 molecules, the two most prevalent A3-supertype alleles. Sixty-six of the peptides were found to bind one of the two alleles with binding affinities of ≦500 nM (Table XXVIII). These peptides were then tested for binding cross-reactivity to the other common A3-supertype alleles (A*3101, A*3301, and A*6801). Twenty one of the peptides bound at least three of the five HLA-A3-supertype molecules tested (Table XXVIII). Table XXVIII also includes two 11-mer peptides that were not selected using the search criteria outlined above, but have been shown to be A3-supertype cross-reactive binders.
Selection of HLA-B7 Supermotif Bearing Epitopes
When the same HIV target antigen protein sequences were also analyzed for the presence of conserved 9- or 10-mer peptides with the HLA-B7-supermotif, 54 sequences were identified. The corresponding peptides were synthesized and tested for binding to HLA-B*0702, the most common B7-supertype allele (i.e., the prototype B7 supertype allele). Sixteen peptides bound B*0702 with IC50 of <500 nM (Table XXIX). These peptides were then tested for binding to other common B7-supertype molecules (B*3501, B*5101, B*5301, and B*5401). As shown in Table XXIX, eight of the sixteen peptides were capable of binding to three or more of the five B7-supertype alleles tested.
Selection of A1 and A24 Motif-Bearing Epitopes
To further increase population coverage, HLA-A1 and -A24 epitopes can also be incorporated into potential vaccine constructs. An analysis of the protein sequence data from the HIV target antigens utilized above can also be performed to identify HLA-A1- and A24-motif-containing conserved sequences.
Other similar, but less extensive, studies performed by the present inventors have identified five conserved HIV-derived peptides that bind to A*0101 with an IC50 of 500 nM or less. (Table XXX). In a similar context, 11 conserved HLA-A*2402-binding HIV-derived peptides have also been identified, 5 of which bind with an IC50 of 100 nM or less (Table XXXI).
Example 3
Confirmation of Immunogenicity
Evaluation of A*0201 Immunogenicity
It has been shown that CTL induced in A*0201/Kb transgenic mice exhibit specificity similar to CTL induced in the human system (see, e.g., Vitiello et al., J. Exp. Med. 173:1007-1015, 1991; Wentworth et al., Eur. J. Immunol. 26:97-101, 1996). Accordingly, these mice were used to evaluate the immunogenicity of 19 of the 20 A2-supertype cross-reactive peptides identified in Example 2 above.
CTL induction in transgenic mice following peptide immunization has been described (Vitiello et al., J. Exp. Med. 173:1007-1015, 1991; Alexander et al.; J. Immunol. 159:4753-4761, 1997). In these studies, mice were injected subcutaneously at the base of the tail with each peptide (50 μg/mouse) emulsified in IFA in the presence of an excess of an IAb-restricted helper peptide (140 μg/mouse) (HBV core 128-140, Sette et al., J. Immunol. 153:5586-5592, 1994). Eleven days after injection, splenocytes were incubated in the presence of peptide-loaded syngenic LPS blasts. After six days, cultures were assayed for cytotoxic activity using peptide-pulsed targets. The data, summarized in Table XXXII, indicate that eight peptides were capable of inducing primary CTL responses in A*0201/Kb transgenic mice. (For these studies, a peptide was considered positive if it induced CTL (L.U. 30/106 cells ≧2 in at least two transgenic animals (Wentworth et al., Eur. J. Immunol. 26:97-101, 1996).
The cross-reactive candidate CTL epitopes were also tested for the ability to stimulate recall CTL reponses HIV-infected patients. Briefly, PBMC from patients infected with HIV were cultured in the presence of 10 μg/ml of synthetic peptide. After 7 and 14 days, the cultures were restimulated with peptide. The cultures were assayed for cytolytic activity on day 21 using target cells pulsed with the specific peptide in a 51Cr release assay. These data are also summarized in Table XXXII. As shown, 15 of the 19 peptides analyzed were recognized in recall CTL responses using PBMC from HIV-infected patients.
The set of peptides screened for immunogenicity contained two redundant peptides, 1261.14 and 1261.04, which differ in length by a single amino acid. While both peptides exhibit supertype degenerate binding, only the short of the two peptides exhibited immunogenicity. One supertype peptide not tested, 1211.09, has been reported to be recognized by CTL lines isolated from HIV-infected patients. In summary, 16 A2-supertype cross-reactive peptides have been identified that are immungenic in humans; 53% of these peptides are also recognized in HLA-A2 transgenic mice. The sixteen peptides represent epitopes from five HIV antigens: env, gag, pol, vpr, and nef.
Evaluation of A*03/A11 Immunogenicity
Twenty one of the A3-supertype cross-reactive peptides identified in Example 2 above were evaluated for immunogenicity (Table XXXIII). Peptides were screened using HLA-A11/Kb transgenic mice, using the protocol described above for HLA-A2 transgenic mice (Alexander et al., J. Immunol. 159:4753-4761, 1997) and using PBMC obtained from HIV-infected patients to test for the ability to stimulate CTL recall responses. Ten peptides that were capable of inducing CTL in HLA-A11 transgenic mice were identified.
Three peptides, 966.01, 940.03, and 1069.47, have been shown by collaborators to be immunogenic in HIV-infected patients. Peptides 966.01 and 1069.47 also induced CTL responses in transgenic mice, peptide 940.03 exhibited immunogenicity in patients only.
In summary, 11 of 23 A3-supertype cross-reactive binding peptides were found to be immunogenic in either HLA-A11 transgenic mice or HIV-infected patients. These peptides represent epitopes from three HIV antigens: pol, env, and nef.
Evaluation of B7 Immunogenicity
Immunogenicity screening of the B7-supertype cross-reactive binding peptides identified in Example 2 can be evaluated using HLA-B7 transgenic mice and PBMC from in HIV-infected patients in a manner analagous to the evaluation of A2-and A3-supermotif-bearing peptides. Three of these peptides have been previously reported as being immunogenic in HIV-infected patients.
Example 4
Implementation of the Extended Supermotif to Improve the Binding Capacity of Native Epitopes by Creating Analogs
HLA motifs and supermotifs (comprising primary and/or secondary residues) are useful in the identification and preparation of highly cross-reactive native peptides, as demonstrated herein. Moreover, the definition of HLA motifs and supermotifs also allows one to engineer highly cross-reactive epitopes by identifying residues within a native peptide sequence which can be analogued, or “fixed” to confer upon the peptide certain characteristics, e.g. greater cross-reactivity within the group of HLA molecules that comprise a supertype, and/or greater binding affinity for some or all of those HLA molecules. Examples of analog peptides that exhibit modulated binding affinity are set forth in this example.
Analoging at Primary Anchor Residues
As shown in Example 2, twenty HIV-derived, A2-supertype-restricted epitopes were identified. Peptide engineering strategies are implemented to further increase the cross-reactivity of the candidate epitopes identified above which bind 3/5 of the A2 supertype alleles tested. On the basis of the data disclosed, e.g., in related and co-pending U.S. Ser. No. 09/226,775, the main anchors of A2-supermotif-bearing peptides are altered, for example, to introduce a preferred L, I, V, or M at position 2, and I or V at the C-terminus.
To analyze the cross-reactivity of the analog peptides, each engineered analog is initially tested for binding to the prototype A2 supertype allele A*0201, then, if A*0201 binding capacity is maintained, for A2-supertype cross-reactivity.
Alternatively, a peptide may be tested for binding to one or all supertype members and then analogued to modulate binding affinity to any one (or more) of the supertype members to add population coverage.
Similarly, analogs of HLA-A3 supermotif-bearing epitopes may also be generated. For example, peptides binding to 3/5 of the A3-supertype molecules may be engineered at primary anchor residues to possess a preferred residue (V, S, M, or A) at position 2.
The analog peptides are then tested for the ability to bind A*03 and A*11 (prototype A3 supertype alleles). Those peptides that demonstrate ≦500 nM binding capacity are then tested for A3-supertype cross-reactivity.
Similarly to the A2- and A3-motif bearing peptides, peptides binding 3 or more B7-supertype alleles may be improved, where possible, to achieve increased cross-reactive binding. B7 supermotif-bearing peptides may, for example, be engineered to possess a preferred residue (V, I, L, or F) at the C-terminal primary anchor position, as demonstrated by Sidney et al. (J. Immunol. 157:3480-3490, 1996).
Analoging at Secondary Anchor Residues
Moreover, HLA supermotifs are of value in engineering highly cross-reactive peptides and/or peptides that bind HLA molecules with increased affinity by identifying particular residues at secondary anchor positions that are associated with such properties. For example, the binding capacity of a B7 supermotif-bearing peptide representing a discreet single amino acid substitution at position 1 can be analyzed. A peptide such as t Peptide 1261.01 (Table XXIX), can, for example, be analogued to substitute L for F at position 1 and subsequently be evaluated for increased binding affinity/and or increased cross-reactivity. This procedure will identify analogued peptides with modulated binding affinity.
Engineered analogs with sufficiently improved binding capacity or cross-reactivity are tested for immunogenicity in HLA-B7-transgenic mice, following for example, IFA immunization or lipopeptide immunization. The analogued peptides may be additionally tested for the ability to stimulate a recall response using PBMC from HIV-infected patients. In conclusion, these data demonstrate that by the use of even single amino acid substitutions, it is possible to increase the binding affinity and/or cross-reactivity of peptide ligands for HLA supertype molecules.
Example 5
Identification of HIV-Derived Sequences with HLA-DR Binding Motifs
Peptide epitopes bearing an HLA class II supermotif or motif may also be identified as outlined below using methodology similar to that described in Examples 1-3.
Selection of HLA-DR-Supermotif-Bearing Epitopes.
To identify HIV-derived, HLA class II HTL epitopes, the protein sequences from the same HIV antigens used for the identification of HLA Class I supermotif/motif sequences were analyzed for the presence of sequences bearing an HLA-DR-motif or supermotif. Specifically, 15-mer sequences were selected comprising a DR-supermotif, further comprising a 9-mer core, and three-residue N- and C-terminal flanking regions (15 amino acids total).
Protocols for predicting peptide binding to DR molecules have been developed (Southwood et al., J. Immunol. 160:3363-3373, 1998). These protocols, specific for individual DR molecules, allow the scoring, and ranking, of 9-mer core regions. Each protocol not only scores peptide sequences for the presence of DR-supermotif primary anchors (i.e., at position I and position 6) within a 9-mer core, but additionally evaluates sequences for the presence of secondary anchors Using allele specific selection tables (see, e.g., Southwood et al., ibid.), it has been found that these protocols efficiently select peptide sequences with a high probability of binding a particular DR molecule. Additionally, it has been found that performing these protocols in tandem, specifically those for DR1, DR4w4, and DR7, can efficiently select DR cross-reactive peptides. The HIV-derived peptides identified above were tested for their binding capacity for various common HLA-DR molecules. All peptides were initially tested for binding to the DR molecules in the primary panel: DR1, DR4w4, and DR7. Peptides binding at least 2 of these 3 DR molecules were then tested for binding to DR2w2 β1, DR2w2 β2, DR6w19, and DR9 molecules in secondary assays. Finally, peptides binding at least 2 of the 4 secondary panel DR molecules, and thus cumulatively at least 4 of 7 different DR molecules, were screened for binding to DR4w15, DR5w11, and DR8w2 molecules in tertiary assays. Peptides binding at least 7 of the 10 DR molecules comprising the primary, secondary, and tertiary screening assays were considered cross-reactive DR binders. The composition of these screening panels, and the phenotypic frequency of associated antigens, are shown in Table XXXIV.
Thirteen HIV-derived peptides were found to bind at least 7 of 10 common HLA-DR alleles. The sequence of these 13 peptides, and their binding capacity for each assay in the primary through tertiary panels, are shown in Table XXXV. This set of peptide epitopes is predominantly derived from pol, but also includes epitopes from gag and env.
Selection of DR3 Motif Peptides
Because HLA-DR3 is an allele that is prevalent in Caucasian, Black, and Hispanic populations, DR3 binding capacity is an important criterion in the selection of HTL epitopes. However, data generated previously indicated that DR3 only rarely cross-reacts with other DR alleles (Sidney et al., J. Immunol. 149:2634-2640, 1992; Geluk et al., J. Immunol. 152:5742-5748, 1994; Southwood et al., J. Immunol. 160:3363-3373, 1998). This is not entirely surprising in that the DR3 peptide-binding motif appears to be distinct from the specificity of most other DR alleles. For maximum efficiency in developing vaccine candidates it would be desirable for DR3 motifs to be clustered in proximity with DR supermotif regions. Thus, peptides shown to be candidates may also be assayed for their DR3 binding capacity. However, in view of the distinct binding specifity of the DR3 motif, peptides binding only to DR3 can also be ocnsidered as candidates for inclusion in a vaccine formulation.
To efficiently identify peptides that bind DR3, the nine target HIV antigens were analyzed for conserved sequences carrying one of the two DR3 specific binding motifs reported by Geluk et al. (J. Immunol. 152:5742-5748, 1994). The corresponding peptides were then synthesized and tested for the ability to bind DR3 with an affinity of IPM or better, i.e., less than 1 μM. ive peptides were found that met this binding criterion (Table XXXVI), and thereby qualify as HLA class II high affinity binders. Of these five, four represent epitopes from pol, and one is from vpu.
DR3 binding epitopes identified in this manner may then be included in vaccine compositions with DR supermotif-bearing peptide epitopes.
Example 6
Immunogenicity of HIV-Derived HTL Epitopes
Immunogenicity of HTL epitopes can be evaluated in a manner analagous to the determination of immunogenicity of CTL epitopes using appropriate transgenic mice models and/or assessing the ability to stimulate recall responses using PBMC isolated from HIV-infected individuals.
The immunogenicity of 11 of the 13 HLA class II DR-supermotif binding epitopes identified in Example 5 was evaluated in a study testing PBMC isolated from HIV-infected individuals for recall proliferative responses. All eleven of these peptides were found to stimulate DR-restricted proliferative responses (Table XXXVII).
The DR3-motif bearing peptides can also be evaluated in a similar manner. Such studies demonstrate the immunogenicity of class II epitopes derived from HIV proteins.
Example 7
Calculation of Phenotypic Frequencies of HLA-Supertypes in Various Ethnic Backgrounds to Determine Breadth of Population Coverage
This example illustrates the assessment of the breadth of population coverage of a vaccine composition comprised of multiple epitopes comprising multiple supermotifs and/or motifs.
In order to analyze population coverage, gene frequencies of HLA alleles were determined. Gene frequencies for each HLA allele were calculated from antigen or allele frequencies utilizing the binomial distribution formulae gf=1-(SQRT(1-af)) (see, e.g., Sidney et al., Human Immunol. 45:79-93, 1996). To obtain overall phenotypic frequencies, cumulative gene frequencies were calculated, and the cumulative antigen frequencies derived by the use of the inverse formula [af=1-(1-Cgf)2].
Where frequency data was not available at the level of DNA typing, correspondence to the serologically defined antigen frequencies was assumed. To obtain total potential supertype population coverage no linkage disequilibrium was assumed, and only alleles confirmed to belong to each of the supertypes were included (minimal estimates). Estimates of total potential coverage achieved by inter-loci combinations were made by adding to the A coverage the proportion of the non-A covered population that could be expected to be covered by the B alleles considered (e.g., total=A+B*(1-A)). Confirmed members of the A3-like supertype are A3, A11, A31, A*3301, and A*6801. Although the A3-like supertype may also include A34, A66, and A*7401, these alleles were not included in overall frequency calculations. Likewise, confirmed members of the A2-like supertype family are A*0201, A*0202, A*0203, A*0204, A*0205, A*0206, A*0207, A*6802, and A*6901. Finally, the B7-like supertype-confirmed alleles are: B7, B*3501-03, B51, B*5301, B*5401, B*5501-2, B*5601, B*6701, and B*7801 (potentially also B*1401, B*3504-06, B*4201, and B*5602).
Population coverage achieved by combining the A2-, A3- and B7-supertypes is approximately 86% in five major ethnic groups (see Table XXI). Coverage may be extended by including peptides bearing the A1 and A24 motifs. On average, A1 is present in 12% and A24 in 29% of the population across five different major ethnic groups (Caucasian, North American Black, Chinese, Japanese, and Hispanic). Together, these alleles are represented with an average frequency of 39% in these same ethnic populations. The total coverage across the major ethnicities when A1 and A24 are combined with the coverage of the A2-, A3- and B7-supertype alleles is >95%. An analagous approach can be used to estimate population coverage achieved with combinations of class II motif-bearing epitopes.
Summary of Candidate HLA class I Epitopes
In summary, on the basis of the data presented in the above examples, 47 candidate CTL peptide epitopes derived from HIV have been identified (see, Table XXXVIII). Of these 47 eptiopes, 6 are derived from gag, 22 from pol, 10 from env, 3 from nef, and one epitope each from rev, vif, and vpr. This set of epitopes includes 16 HLA-A2 supermotif-bearing epitopes (two from gag, eight from pol, three from env, two from vpr, and one from nef), all of which are recognized in HIV-infected patients. The 10 HLA-A3 supermotif-bearing candidate epitopes include 6 pol-derived epitopes, two env-derived epitopes and one eptiope each from gag, vif, and nef. With the exception of peptides 1273.08 and 1273.03, all of the epitopes are immunogenic in HLA transgenic mice. The two additional peptides are included to enhance antigen diversity.
The CTL candidate epitope set also includes 8 B7-restricted peptides. Of these eight, 3 epitopes have been reported as immunogenic in patients. Five B7-supermotif-bearing peptides were included as candidates based on supertype binding. Immunogenicity studies in humans (e.g., Bertoni et al., J. Clin. Invest. 100:503, 1997; Doolan et al., Immunity 7:97, 1997; and Threlkeld et al., J. Immunol. 159:1648, 1997) have shown that highly cross-reactive binding peptides are almost always recognized as epitopes. Given these results, and in view of the limited immunogenicity data available for B7 supermotif-bearing peptides, the use of B7-supertype binding affinity is an important selection criterion in identifying candidate epitopes for inclusion in a vaccine that is immunogenic in a diverse population.
Similarly, A1- and A24-restricted peptides were included on the basis of both demonstrated immunogenicity of the candidate epitopes and on the basis of binding affinity. Five of the candidate epitopes have been reported to be recognized in recall CTL repsonses form HIV-infected patients. Because a high percentage of the peptides with binding affinities ≦100 nM are found to be immunogenic, four A24-restricted peptides were included as vaccine candidates. An additional five A24-restricted epitopes and four A1-restricted epitopes that bound their respective alleles with an IC50 of <500 nM were also included to provide a greater degree of population coverage.
With these 47 CTL epitopes (as disclosed herein and from the art), an average population coverage is predicted to be greater than 95% in each of five major ethnic populations. Using the game theory Monte Carlo simulation analysis, which is known in the art (see e.g., Osborne, M. J. and Rubinstein, A. “A course in game theory” MIT Press, 1994), it is estimated that 90% of the individuals in a population comprised of the Caucasian, North American Black, Japanese, Chinese, and Hispanic ethnic groups would recognize 7 or more of the vaccine epitopes described herein (FIG. 1)
Summary of Candidate HLA class II Epitopes
A list of HIV-derived HTL epitopes that would be preferred for use in the design of minigene constructs or other vaccine formulations is summarized in Table XXXIX. The set of HTL epitopes includes 13 DR supermotif-bearing peptides and 5 DR3 motif-bearing peptides. The majority of the epitopes are derived from pol, 3 are from gag, 2 are from env and one is derived from vpu. The total estimated population coverage represented by this panel of HTL epitopes is estimated to be greater than 91% in each of five major ethnic groups (Table XL).
Example 8
CTL Recognition Of Endogenous Processed Antigens After Priming
This example determines that CTL induced by native or analogued peptide epitopes identified and selected as described in Examples 1-6 recognize endogenously synthesized, i.e., native antigens.
Effector cells isolated from transgenic mice that are immunized with peptide epitopes as in Example 3, for example HLA-A2 supermotif-bearing epitopes, are re-stimulated in vitro using peptide-coated stimulator cells. Six days later, effector cells are assayed for cytotoxicity and the cell lines that contain peptide-specific cytotoxic activity are further re-stimulated. An additional six days later, these cell lines are tested for cytotoxic activity on 51Cr labeled Jurkat-A2.1/Kb target cells in the absence or presence of peptide, and also tested on 51Cr labeled target cells bearing the endogenously synthesized antigen, i.e. cells that are stably transfected with HIV expression vectors.
The result will demonstrate that CTL lines obtained from animals primed with peptide epitope recognize endogenously synthesized HIV antigen. The choice of transgenic mouse model to be used for such an analysis depends upon the epitope(s) that is being evaluated. In addition to HLA-A*0201/Kb transgenic mice, several other transgenic mouse models including mice with human A11, which may also be used to evaluate A3 epitopes, and B7 alleles have been characterized and others (e.g., transgenic mice for HLA-A1 and A24) are being developed. HLA-DR1 and HLA-DR3 mouse models have also been developed, which may be used to evaluate HTL epitopes.
Example 9
Activity of CTL-HTL Conjugated Epitopes in Transgenic Mice
This example illustrates the induction of CTLs and HTLs in transgenic mice by use of a HIV CTL/HTL peptide conjugate whereby the vaccine composition comprises peptides administered to an HIV-infected patient or an individual at risk for HIV. The peptide composition can comprise multiple CTL and/or HTL epitopes. This analysis demonstrates enhanced immunogenicity that can be achieved by inclusion of one or more HTL epitopes in a vaccine composition. Such a peptide composition can comprise a lipidated HTL epitope conjugated to a preferred CTL epitope containing, for example, at least one CTL epitope selected from Table XXVI-XXIX, or an analog of that epitope. The HTL epitope is, for example, selected from Table XXXII.
Lipopeptide preparation: Lipopeptides are prepared by coupling the appropriate fatty acid to the amino terminus of the resin bound peptide. A typical procedure is as follows: A dichloromethane solution of a four-fold excess of a pre-formed symmetrical anhydride of the appropriate fatty acid is added to the resin and the mixture is allowed to react for two hours. The resin is washed with dichloromethane and dried. The resin is then treated with trifluoroacetic acid in the presence of appropriate scavengers [e.g. 5% (v/v) water] for 60 minutes at 20° C. After evaporation of excess trifluoroacetic acid, the crude peptide is washed with diethyl ether, dissolved in methanol and precipitated by the addition of water. The peptide is collected by filtration and dried.
Immunization procedures: Immunization of transgenic mice is performed as described (Alexander et al., J. Immunol. 159:4753-4761, 1997). For example, A2/Kb mice, which are transgenic for the human HLA A2.1 allele and are useful for the assessment of the immunogenicity of HLA-A*0201 motif- or HLA-A2 supermotif-bearing epitopes, are primed subcutaneously (base of the tail) with 0.1 ml of peptide conjugate formulated in saline, or DMSO/saline. Seven days after priming, splenocytes obtained from these animals are restimulated with syngenic irradiated LPS-activated lymphoblasts coated with peptide.
Cell lines: Target cells for peptide-specific cytotoxicity assays are Jurkat cells transfected with the HLA-A2.1/Kb chimeric gene (e.g., Vitiello et al., J. Exp. Med. 173:1007, 1991)
In vitro CTL activation: One week after priming, spleen cells (30×106 cells/flask) are co-cultured at 37° C. with syngeneic, irradiated (3000 rads), peptide coated lymphoblasts (10×10” cells/flask) in 10 ml of culture medium/T25 flask. After six days, effector cells are harvested and assayed for cytotoxic activity.
Assay for cytotoxic activity: Target cells (1.0 to 1.5×106) are incubated at 37° C. in the presence of 200 μl, of 51Cr. After 60 minutes, cells are washed three times and resuspended in R10 medium. Peptide is added where required at a concentration of 1 μg/ml. For the assay, 104 51Cr-labeled target cells are added to different concentrations of effector cells (final volume of 200 μl) in U-bottom 96-well plates. After a 6 hour incubation period at 37° C., a 0.1 ml aliquot of supernatant is removed from each well and radioactivity is determined in a Micromedic automatic gamma counter. The percent specific lysis is determined by the formula: percent specific release=100×(experimental release−spontaneous release)/(maximum release−spontaneous release). To facilitate comparison between separate CTL assays run under the same conditions, % 51Cr release data is expressed as lytic units/106 cells. One lytic unit is arbitrarily defined as the number of effector cells required to achieve 30% lysis of 10,000 target cells in a 6 hour 51Cr release assay. To obtain specific lytic units/106, the lytic units/106 obtained in the absence of peptide is subtracted from the lytic units/I 106 obtained in the presence of peptide. For example, if 30% 51Cr release is obtained at the effector (E): target (T) ratio of 50:1 (i.e., 5×105 effector cells for 10,000 targets) in the absence of peptide and 5:1 (i.e., 5×104 effector cells for 10,000 targets) in the presence of peptide, the specific lytic units would be: [(1/50,000)-(1/500,000)]×106=18 LU.
The results are analyzed to assess the magnitude of the CTL responses of animals injected with the immunogenic CTL/HTL conjugate vaccine preparation and are compared to the magnitude of the CTL response achieved using the CTL epitope as outlined in Example 3. Analyses similar to this may be performed to evaluate the immunogenicity of peptide conjugates containing multiple CTL epitopes and/or multiple HTL epitopes. In accordance with these procedures it is found that a CTL response is induced, and concomitantly that an HTL response is induced upon administration of such compositions.
Example 10
Selection of CTL and HTL Epitopes for Inclusion in an HIV-Specific Vaccine
This example illustrates the procedure for the selection of peptide epitopes for vaccine compositions of the invention. The peptides in the composition may be in the form of a nucleic acid sequence, either single or one or more sequences (i.e., minigene) that encodes peptide(s), or may be single and/or polyepitopic peptides.
The following principles are utilized when selecting an array of epitopes for inclusion in a vaccine composition. Each of the following principles are balanced in order to make the selection.
1.) Epitopes are selected which, upon administration, mimic immune responses that have been observed to be correlated with HIV clearance. For HLA Class I this includes 3-4 epitopes that come from at least one antigen of HIV. In other words, it has been observed that patients who spontaneously clear HIV generate an immune response to at least 3 epitopes on at least one HIV antigen. For HLA Class II a similar rationale is employed; again 3-4 epitopes are selected from at least one HIV antigen.
2.) Epitopes are selected that have the requisite binding affinity established to be correlated with immunogenicity: for HLA Class I an IC50 of 500 nM or less, or for Class II an IC50 of 1000 nM or less.
3.) Sufficient supermotif bearing peptides, or a sufficient array of allele-specific motif bearing peptides, are selected to give broad population coverage. For example, epitopes are selected to provide at least 80% population coverage. A Monte Carlo analysis, a statistical evaluation known in the art and discussed herein, can be employed to assess breadth, or redundancy, of population coverage.
4.) When selecting epitopes for HIV antigens it may be preferable to select native epitopes. Therefore, of particular relevance for infectious disease vaccines, are epitopes referred to as “nested epitopes.” Nested epitopes occur where at least two epitopes overlap in a given peptide sequence. A peptide comprising “transcendent nested epitopes” is a peptide that has both HLA class I and HLA class II epitopes in it.
When providing nested epitopes, a sequence that has the greatest number of epitopes per provided sequence is provided. A limitation on this principle is to avoid providing a peptide that is any longer than the amino terminus of the amino terminal epitope and the carboxyl terminus of the carboxyl terminal epitope in the peptide. When providing a longer peptide sequence, such as a sequence comprising nested epitopes, the sequence is screened in order to insure that it does not have pathological or other deleterious biological properties.
5.) When creating a minigene, as disclosed in greater detail in Example 11, an objective is to generate the smallest peptide possible that encompasses the epitopes of interest. The principles employed are similar, if not the same as those employed when selecting a peptide comprising nested epitopes. Additionally, however, upon determination of the nucleic acid sequence to be provided as a minigene, the peptide encoded thereby is analyzed to determine whether any “junctional epitopes” have been created. A junctional epitope is an actual binding epitope, as predicted, e.g., by motif analysis. Junctional epitopes are generally to be avoided because the recipient may generate an immune response to that epitope, which is not present in a native HIV protein sequence. Of particular concern is a junctional epitope that is a “dominant epitope.” A dominant epitope may lead to such a zealous response that immune responses to other epitopes are diminished or suppressed.
Peptide epitopes for inclusion in vaccine compositions are, for example, selected from those listed in Tables XXVI-XXIX and Table XXXII. A vaccine composition comprised of selected peptides, when administered, is safe, efficacious, and elicits an immune response similar in magnitude of an immune response that clears an acute HIV infection.
Example 11
Construction of Minigene Multi-Epitope DNA Plasmids
This example provides general guidance for the construction of a minigene expression plasmid. Minigene plasmids may, of course, contain various configurations of CTL and/or HTL epitopes or epitope analogs as described herein. Expression plasmids have been constructed and evaluated as described, for example, in co-pending U.S. Ser. No. 09/311,784 filed May 13, 1999 and in Ishioka et al., J. Immunol. 162:3915-3925, 1999. An example of such a plasmid for the expression of HIV epitopes is shown in FIG. 2, which illustrates the orientation of HIV peptide epitopes in a minigene construct.
A minigene expression plasmid may include multiple CTL and HTL peptide epitopes. In the present example, HLA-A2, -A3, -B7 supermotif-bearing peptide epitopes and HLA-A1 and -A24 motif-bearing peptide epitopes are used in conjunction with DR supermotif-bearing epitopes and/or DR3 epitopes (FIG. 2). Preferred epitopes are identified, for example, in Tables XXVI-XXIX and XXXII. HLA class I supermotif or motif-bearing peptide epitopes derived from multiple HIV antigens, are selected such that multiple supermotifs/motifs are represented to ensure broad population coverage. Similarly, HLA class II epitopes are selected from multiple HIV antigens to provide broad population coverage, i.e. both HLA DR-1-4-7 supermotif-bearing epitopes and HLA DR-3 motif-bearing epitopes are selected for inclusion in the minigene construct. The selected CTL and HTL epitopes are then incorporated into a minigene for expression in an expression vector.
Such a construct may additionally include sequences that direct the HTL epitopes to the endoplasmic reticulum. For example, the Ii protein may be fused to one or more HTL epitopes as described in co-pending application U.S. Ser. No. 09/311,784 filed May 13, 1999, wherein the CLIP sequence of the Ii protein is removed and replaced with an HLA class II epitope sequence os that HLA class II epitope is directed to the endoplasmic reticulum, where the epitope binds to an HLA class II molecules.
This example illustrates the methods to be used for construction of a minigene-bearing expression plasmid. Other expression vectors that may be used for minigene compositions are available and known to those of skill in the art.
The minigene DNA plasmid contains a consensus Kozak sequence and a consensus murine kappa Ig-light chain signal sequence followed by CTL and/or HTL epitopes selected in accordance with principles disclosed herein. The construct can also include, for example, The sequence encodes an open reading frame fused to the Myc and His antibody epitope tag coded for by the pcDNA 3.1 Myc-His vector.
Overlapping oligonucleotides, for example eight oligonucleotides, averaging approximately 70 nucleotides in length with 15 nucleotide overlaps, are synthesized and HPLC-purified. The oligonucleotides encode the selected peptide epitopes as well as appropriate linker nucleotides, Kozak sequence, and signal sequence. The final multiepitope minigene is assembled by extending the overlapping oligonucleotides in three sets of reactions using PCR. A Perkin/Elmer 9600 PCR machine is used and a total of 30 cycles are performed using the following conditions: 95° C. for 15 sec, annealing temperature (5° below the lowest calculated Tm of each primer pair) for 30 sec, and 72° C. for 1 min.
For the first PCR reaction, 5 μg of each of two oligonucleotides are annealed and extended: Oligonucleotides 1+2, 3+4, 5+6, and 7+8 are combined in 100 μl reactions containing Pfu polymerase buffer (1×=10 mM KCL, 10 mM (NH4)2SO4, 20 mM Tris-chloride, pH 8.75, 2 mM MgSO4, 0.1% Triton X-100, 100 μg/ml BSA), 0.25 mM each dNTP, and 2.5 U of Pfu polymerase. The full-length dimer products are gel-purified, and two reactions containing the product of 1+2 and 3+4, and the product of 5+6 and 7+8 are mixed, annealed, and extended for 10 cycles. Half of the two reactions are then mixed, and 5 cycles of annealing and extension carried out before flanking primers are added to amplify the full length product for 25 additional cycles. The full-length product is gel-purified and cloned into pCR-blunt (Invitrogen) and individual clones are screened by sequencing.
Example 12
The Plasmid Construct and the Degree to Which it Induces Immunogenicity
The degree to which the plasmid construct prepared using the methodology outlined in Example 11 is able to induce immunogenicity is evaluated through in vivo injections into mice and subsequent in vitro assessment of CTL and HTL activity, which are analysed using cytotoxicity and proliferation assays, respectively, as detailed e.g., in U.S. Ser. No. 09/311,784 filed May 13, 1999 and Alexander et al., Immunity 1:751-761, 1994. To assess the capacity of the pMin minigene construct to induce CTLs in vivo, HLA-A11/Kb transgenic mice, for example, are immunized intramuscularly with 100 μg of naked cDNA. As a means of comparing the level of CTLs induced by cDNA immunization, a control group of animals is also immunized with an actual peptide composition that comprises multiple epitopes synthesized as a single polypeptide as they would be encoded by the minigene.
Splenocytes from immunized animals are stimulated twice with each of the respective compositions (peptide epitopes encoded in the minigene or the polyepitopic peptide), then assayed for peptide-specific cytotoxic activity in a 51Cr release assay. The results indicate the magnitude of the CTL response directed against the A3-restricted epitope, thus indicating the in vivo immunogenicity of the minigene vaccine and polyepitopic vaccine. It is, therefore, found that the minigene elicits immune responses directed toward the HLA-A3 supermotif peptide epitopes as does the polyepitopic peptide vaccine. A similar analysis is also performed using other HLA-A2 and HLA-B7 transgenic mouse models to assess CTL induction by HLA-A2 and HLA-B7 motif or supermotif epitopes.
To assess the capacity of a class II epitope encoding minigene to induce HTLs in vivo, I-Ab restricted mice, for example, are immunized intramuscularly with 100 μg of plasmid DNA. As a means of comparing the level of HTLs induced by DNA immunization, a group of control animals is also immunized with an actual peptide composition emulsified in complete Freund's adjuvant.
CD4+ T cells, i.e. HTLs, are purified from splenocytes of immunized animals and stimulated with each of the respective compositions (peptides encoded in the minigene). The HTL response is measured using a 3H-thymidine incorporation proliferation assay, (see, e.g., Alexander et al. Immunity 1:751-761, 1994). the results indicate the magnitude of the HTL response, thus demonstrating the in vivo immunogenicity of the minigene.
DNA minigenes, constructed as described in Example 11, may also be evaluated as a vaccine in combination with a boosting agent using a prime boost protocol. The boosting agent may consist of recombinant protein (e.g., Barnett et al., Aids Res. and Human Reotroviruses 14, Supplement 3:S299-S309, 1998) or recombinant vaccinia, for example, expressing a minigene or DNA encoding the complete protein of interest (see, e.g., Hanke et al., Vaccine 16:439-445, 1998; Sedegah et al., Proc. Natl. Acad. Sci USA 95:7648-53, 1998; Hanke and McMichael, Immunol. Letters 66:177-181, 1999; and Robinson et al., Nature Med. 5:526-34, 1999).
For example, the efficacy of the DNA minigene may be evaluated in transgenic mice. In this example, A2.1/Kb transgenic mice are immunized IM with 100 μg of the DNA minigene encoding the immunogenic peptides. After an incubation period (ranging from 3-9 weeks), the mice are boosted IP with 107 pfui/mouse of a recombinant vaccinia virus expressing the same sequence encoded by the DNA minigene. Control mice are immunized with 100 μg of DNA or recombinant vaccinia without the minigene sequence, or with DNA encoding the minigene, but without the vaccinia boost. After an additional incubation period of two weeks, splenocytes from the mice are immediately assayed for peptide-specific activity in an ELISPOT assay. Additionally, splenocytes are stimulated in vitro with the A2-restricted peptide epitopes encoded in the minigene and recombinant vaccinia, then assayed for peptide-specific activity in an IFN-γ ELISA. It is found that the minigene utilized in a prime-boost mode elicits greater immune responses toward the HLA-A2 supermotif peptides than with DNA alone. Such an analysis is also performed using other HLA-A11 and HLA-B7 transgenic mouse models to assess CTL induction by HLA-A3 and HLA-B7 motif or supermotif epitopes.
Example 13
Peptide Composition for Prophylactic Uses
Vaccine compositions of the present invention are used to prevent HIV infection in persons who are at risk for such infection. For example, a polyepitopic peptide epitope composition (or a nucleic acid comprising the same) containing multiple CTL and HTL epitopes such as those selected in Examples 9 and/or 10, which are also selected to target greater than 80% of the population, is administered to individuals at risk for HIV infection. The composition is provided as a single lipidated polypeptide that encompasses multiple epitopes. The vaccine is administered in an aqueous carrier comprised of Freunds Incomplete Adjuvant. The dose of peptide for the initial immunization is from about 1 to about 50,000 μg, generally 100-5,000 μg, for a 70 kg patient. The initial administration of vaccine is followed by booster dosages at 4 weeks followed by evaluation of the magnitude of the immune response in the patient, by techniques that determine the presence of epitope-specific CTL populations in a PBMC sample. Additional booster doses are administered as required. The composition is found to be both safe and efficacious as a prophylaxis against HIV infection.
Alternatively, the polyepitopic peptide composition can be administered as a nucleic acid in accordance with methodologies known in the art and disclosed herein.
Example 14
Polyepitopic Vaccine Compositions Derived from Native HIV Sequences
A native HIV polyprotein sequence is screened, preferably using computer algorithms defined for each class I and/or class II supermotif or motif, to identify “relatively short” regions of the polyprotein that comprise multiple epitopes and is preferably less in length than an entire native antigen. This relatively short sequence that contains multiple distinct, even overlapping, epitopes is selected and used to generate a minigene construct. The construct is engineered to express the peptide, which corresponds to the native protein sequence. The “relatively short” peptide is generally less than 250 amino acids in length, often less than 100 amino acids in length, preferably less than 75 amino acids in length, and more preferably less than 50 amino acids in length. The protein sequence of the vaccine composition is selected because it has maximal number of epitopes contained within the sequence, i.e., it has a high concentration of epitopes. As noted herein, epitope motifs may be nested or overlapping (i.e., frame shifted relative to one another). For example, with frame shifted overlapping epitopes, two 9-mer epitopes and one 10-mer epitope can be present in a 10 amino acid peptide. Such a vaccine composition is administered for therapeutic or prophylactic purposes.
The vaccine composition will preferably include, for example, three CTL epitopes and at least one HTL epitope from HIV. This polyepitopic native sequence is administered either as a peptide or as a nucleic acid sequence which encodes the peptide. Alternatively, an analog can be made of this native sequence, whereby one or more of the epitopes comprise substitutions that alter the cross-reactivity and/or binding affinity properties of the polyepitopic peptide.
The embodiment of this example provides for the possibility that an as yet undiscovered aspect of immune system processing will apply to the native nested sequence and thereby facilitate the production of therapeutic or prophylactic immune response-inducing vaccine compositions. Additionally such an embodiment provides for the possibility of motif-bearing epitopes for an HLA makeup that is presently unknown. Furthermore, this embodiment (absent analogs) directs the immune response to multiple peptide sequences that are actually present in native HIV antigens thus avoiding the need to evaluate any junctional epitopes. Lastly, the embodiment provides an economy of scale when producing nucleic acid vaccine compositions.
Related to this embodiment, computer programs can be derived in accordance with principles in the art, which identify in a target sequence, the greatest number of epitopes per sequence length.
Example 15
Polyepitopic Vaccine Compositions Directed To Multiple Diseases
The HIV peptide epitopes of the present invention are used in conjunction with peptide epitopes from target antigens related to one or more other diseases, to create a vaccine composition that is useful for the prevention or treatment of HIV as well as the one or more other disease(s). Examples of the other diseases include, but are not limited to, HCV and HBV.
For example, a polyepitopic peptide composition comprising multiple CTL and HTL epitopes that target greater than 98% of the population may be created for administration to individuals at risk for both HBV and HIV infection. The composition can be provided as a single polypeptide that incorporates the multiple epitopes from the various disease-associated sources, or can be administered as a composition comprising one or more discrete epitopes.
Example 16
Use of Peptides to Evaluate an Immune Response
Peptides of the invention may be used to analyze an immune response for the presence of specific CTL or HTL populations directed to HIV. Such an analysis may be performed in a manner as that described by Ogg et al., Science 279:2103-2106, 1998. In the following example, peptides in accordance with the invention are used as a reagent for diagnostic or prognostic purposes, not as an immunogen.
In this example highly sensitive human leukocyte antigen tetrameric complexes (“tetramers”) are used for a cross-sectional analysis of, for example, HIV HLA-A*0201-specific CTL frequencies from HLA A*0201-positive individuals at different stages of infection or following immunization using an HIV peptide containing an A*0201 motif. Tetrameric complexes are synthesized as described (Musey et al., N. Engl. J. Med. 337:1267, 1997). Briefly, purified HLA heavy chain (A*0201 in this example) and P2-microglobulin are synthesized by means of a prokaryotic expression system. The heavy chain is modified by deletion of the transmembrane-cytosolic tail and COOH-terminal addition of a sequence containing a BirA enzymatic biotinylation site. The heavy chain, P2-microglobulin, and peptide are refolded by dilution. The 45-kD refolded product is isolated by fast protein liquid chromatography and then biotinylated by BirA in the presence of biotin (Sigma, St. Louis, Mo.), adenosine 5′triphosphate and magnesium. Streptavidin-phycoerythrin conjugate is added in a 1:4 molar ratio, and the tetrameric product is concentrated to 1 mg/ml. The resulting product is referred to as tetramer-phycoerythrin.
For the analysis of patient blood samples, approximately one million PBMCs are centrifuged at 300 g for 5 minutes and resuspended in 50 μl of cold phosphate-buffered saline. Tri-color analysis is performed with the tetramer-phycoerythrin, along with anti-CD8-Tricolor, and anti-CD38. The PBMCs are incubated with tetramer and antibodies on ice for 30 to 60 min and then washed twice before formaldehyde fixation. Gates are applied to contain >99.98% of control samples. Controls for the tetramers include both A*0201-negative individuals and A*0201-positive uninfected donors. The percentage of cells stained with the tetramer is then determined by flow cytometry. The results indicate the number of cells in the PBMC sample that contain epitope-restricted CTLs, thereby readily indicating the extent of immune response to the HIV epitope, and thus the stage of infection with HIV, the status of exposure to HIV, or exposure to a vaccine that elicits a protective or therapeutic response.
Example 17
Use of Peptide Epitopes to Evaluate Recall Responses
The peptide epitopes of the invention are used as reagents to evaluate T cell responses, such as acute or recall responses, in patients. Such an analysis may be performed on patients who have recovered from infection, who are chronically infected with HIV, or who have been vaccinated with an HIV vaccine.
For example, the class I restricted CTL response of persons who have been vaccinated may be analyzed. The vaccine may be any HIV vaccine. PBMC are collected from vaccinated individuals and HLA typed. Appropriate peptide epitopes of the invention that, optimally, bear supermotifs to provide cross-reactivity with multiple HLA supertype family members, are then used for analysis of samples derived from individuals who bear that HLA type.
PBMC from vaccinated individuals are separated on Ficoll-Histopaque density gradients (Sigma Chemical Co., St. Louis, Mo.), washed three times in HBSS (GIBCO Laboratories), resuspended in RPMI-1640 (GIBCO Laboratories) supplemented with L-glutamine (2 mM), penicillin (50 U/ml), streptomycin (50 μg/ml), and Hepes (10 mM) containing 10% heat-inactivated human AB serum (complete RPMI) and plated using microculture formats. A synthetic peptide comprising an epitope of the invention is added at 10 μg/ml to each well and HBV core 128-140 epitope is added at 1 μg/ml to each well as a source of T cell help during the first week of stimulation.
In the microculture format, 4×105 PBMC are stimulated with peptide in 8 replicate cultures in 96-well round bottom plate in 100 l/well of complete RPMI. On days 3 and 10, 100 ml of complete RPMI and 20 U/ml final concentration of rIL-2 are added to each well. On day 7 the cultures are transferred into a 96-well flat-bottom plate and restimulated with peptide, rIL-2 and 105 irradiated (3,000 rad) autologous feeder cells. The cultures are tested for cytotoxic activity on day 14. A positive CTL response requires two or more of the eight replicate cultures to display greater than 10% specific 51Cr release, based on comparison with uninfected control subjects as previously described (Rehermann, et al., Nature Med. 2:1104,1108, 1996; Rehermann et al, J. Clin. Invest. 97:1655-1665, 1996; and Rehermann et al. J. Clin. Invest. 98:1432-1440, 1996).
Target cell lines are autologous and allogeneic EBV-transformed B-LCL that are either purchased from the American Society for Histocompatibility and Immunogenetics (ASHI, Boston, Mass.) or established from the pool of patients as described (Guilhot, et al. J. Virol. 66:2670-2678, 1992).
Cytotoxicity assays are performed in the following manner. Target cells consist of either allogeneic HLA-matched or autologous EBV-transformed B lymphoblastoid cell line that are incubated overnight with the synthetic peptide epitope of the invention at 10 μM, and labeled with 100 μCi of 51Cr (Amersham Corp., Arlington Heights, Ill.) for 1 hour after which they are washed four times with HBSS.
Cytolytic activity is determined in a standard 4-h, split well 51Cr release assay using U-bottomed 96 well plates containing 3,000 targets/well. Stimulated PBMC are tested at effector/target (E/T) ratios of 20-50:1 on day 14. Percent cytotoxicity is determined from the formula: 100×[(experimental release-spontaneous release)/maximum release-spontaneous release)]. Maximum release is determined by lysis of targets by detergent (2% Triton X-100; Sigma Chemical Co., St. Louis, Mo.). Spontaneous release is <25% of maximum release for all experiments.
The results of such an analysis indicate the extent to which HLA-restricted CTL populations have been stimulated by previous exposure to HIV or an HIV vaccine.
The class II restricted HTL responses may also be analyzed. Purified PBMC are cultured in a 96-well flat bottom plate at a density of 1.5×105 cells/well and are stimulated with 10 μg/ml synthetic peptide, whole antigen, or PHA. Cells are routinely plated in replicates of 4-6 wells for each condition. After seven days of culture, the medium is removed and replaced with fresh medium containing 10 U/ml IL-2. Two days later, 1 μCi 3H-thymidine is added to each well and incubation is continued for an additional 18 hours. Cellular DNA is then harvested on glass fiber mats and analyzed for 3H-thymidine incorporation. Antigen-specific T cell proliferation is calculated as the ratio of 3H-thymidine incorporation in the presence of antigen divided by the 3H-thymidine incorporation in the absence of antigen.
Example 18
Induction of Specific CTL Response in Humans
A human clinical trial for an immunogenic composition comprising CTL and HTL epitopes of the invention is set up as an IND Phase I, dose escalation study and carried out as a randomized, double-blind, placebo-controlled trial. Such a trial is designed, for example, as follows:
A total of about 27 subjects are enrolled and divided into 3 groups:
- Group I: 3 subjects are injected with placebo and 6 subjects are injected with 5 μg of peptide composition;
- Group II: 3 subjects are injected with placebo and 6 subjects are injected with 50 μg peptide composition;
- Group III: 3 subjects are injected with placebo and 6 subjects are injected with 500 μg of peptide composition.
After 4 weeks following the first injection, all subjects receive a booster inoculation at the same dosage.
The endpoints measured in this study relate to the safety and tolerability of the peptide composition as well as its immunogenicity. Cellular immune responses to the peptide composition are an index of the intrinsic activity of this the peptide composition, and can therefore be viewed as a measure of biological efficacy. The following summarize the clinical and laboratory data that relate to safety and efficacy endpoints.
Safety: The incidence of adverse events is monitored in the placebo and drug treatment group and assessed in terms of degree and reversibility.
Evaluation of Vaccine Efficacy: For evaluation of vaccine efficacy, subjects are bled before and after injection. Peripheral blood mononuclear cells are isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation, aliquoted in freezing media and stored frozen. Samples are assayed for CTL and HTL activity.
The vaccine is found to be both safe and efficacious.
Example 19
Phase II Trials in Patients Infected with HIV
Phase II trials are performed to study the effect of administering the CTL-HTL peptide compositions to patients having chronic HIV infection. The main objectives of the trials are to determine an effective dose and regimen for inducing CTLs in chronically infected HIV patients, to establish the safety of inducing a CTL and HTL response in these patients, and to see to what extent activation of CTLs improves the clinical picture of chronically infected HIV patients, as manifested by a reduction in viral load and an increase in CD4+ cells counts. Such a study is designed, for example, as follows:
The studies are performed in multiple centers. The trial design is an open-label, uncontrolled, dose escalation protocol wherein the peptide composition is administered as a single dose followed six weeks later by a single booster shot of the same dose. The dosages are 50, 500 and 5,000 micrograms per injection. Drug-associated adverse effects (severity and reversibility) are recorded.
There are three patient groupings. The first group is injected with 50 micrograms of the peptide composition and the second and third groups with 500 and 5,000 micrograms of peptide composition, respectively. The patients within each group range in age from 21-65, include both males and females, and represent diverse ethnic backgrounds. All of them are infected with HIV for over five years and are HCV, HBV and delta hepatitis virus (HDV) negative, but have positive levels of HIV antigen.
The viral load and CD4+ levels are monitored to assess the effects of administering the peptide compositions. The vaccine composition is found to be both safe and efficacious in the treatment of HIV infection.
Example 20
Induction of CTL Responses Using a Prime Boost Protocol
A prime boost protocol similar in its underlying principle to that used to evaluated the efficacy of a DNA vaccine in transgenic mice, which was described in Example 12, may also be used for the administration of the vaccine to humans. Such a vaccine regimen may include an initial administration of, for example, naked DNA followed by a boost using recombinant virus encoding the vaccine, or recombinant protein/polypeptide or a peptide mixture administered in an adjuvant.
For example, the initial immunization may be performed using an expression vector, such as that constructed in Example 11, in the form of naked nucleic acid administered IM (or SC or ID) in the amounts of 0.5-5 mg at multiple sites. The nucleic acid (0.1 to 1000 μg) can also be administered using a gene gun. Following an incubation period of 3-4 weeks, a booster dose is then administered. The booster can be recombinant fowlpox virus administered at a dose of 5-107 to 5×109 pfu. An alternative recombinant virus, such as an MVA, canarypox, adenovirus, or adeno-associated virus, can also be used for the booster, or the polyepitopic protein or a mixture of the peptides can be administered. For evaluation of vaccine efficacy, patient blood samples will be obtained before immunization as well as at intervals following administration of the initial vaccine and booster doses of the vaccine. Peripheral blood mononuclear cells are isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation, aliquoted in freezing media and stored frozen. Samples are assayed for CTL and HTL activity.
Analysis of the results will indicate that a magnitude of sufficient response to achieve protective immunity against HIV is generated.
Example 21
Administration of Vaccine Compositions Using Dendritic Cells
Vaccines comprising peptide epitopes of the invention may be administered using dendritic cells. In this example, the immunogenic peptide epitopes are used to elicit a CTL and/or HTL response ex vivo.
Ex vivo CTL or HTL responses to a particular antigen (infectious or tumor-associated antigen) are induced by incubating in tissue culture the patient's, or genetically compatible, CTL or HTL precursor cells together with a source of antigen-presenting cells (APC), such as dendritic cells, and the appropriate immunogenic peptides. After an appropriate incubation time (typically about 14 weeks), in which the precursor cells are activated and expanded into effector cells, the cells are infused back into the patient, where they will destroy (CTL) or facilitate destruction (HTL) of their specific target cells, i.e., HIV-infected cells.
Example 22
Alternative Method of Identifying Motif-Bearing Peptides
Another way of identifying motif-bearing peptides is to elute them from cells bearing defined MHC molecules. For example, EBV transformed B cell lines used for tissue typing, have been extensively characterized to determine which HLA molecules they express. In certain cases these cells express only a single type of HLA molecule. These cells can then be infected with a pathogenic organism or transfected with nucleic acids that express the antigen of interest, e.g. HIV regulatory or structural proteins. Thereafter, peptides produced by endogenous antigen processing of peptides produced consequent to infection (or as a result of transfection) will bind to HLA molecules within the cell and be transported and displayed on the cell surface.
The peptides are then eluted from the HLA molecules by exposure to mild acid conditions and their amino acid sequence determined, e.g., by mass spectral analysis (e.g., Kubo et al., J. Immunol. 152:3913, 1994). Because, as disclosed herein, the majority of peptides that bind a particular HLA molecule are motif-bearing, this is an alternative modality for obtaining the motif-bearing peptides correlated with the particular HLA molecule expressed on the cell.
Alternatively, cell lines that do not express any endogenous HLA molecules can be transfected with an expression construct encoding a single HLA allele. These cells may then be used as described, i.e., they may be infected with a pathogenic organism or transfected with nucleic acid encoding an antigen of interest to isolate peptides corresponding to the pathogen or antigen of interest that have been presented on the cell surface. Peptides obtained from such an analysis will bear motif(s) that correspond to binding to the single HLA allele that is expressed in the cell.
As appreciated by one in the art, one can perform a similar analysis on a cell bearing more than one HLA allele and subsequently determine peptides specific for each HLA allele expressed. Moreover, one of skill would also recognize that means other than infection or transfection, such as loading with a protein antigen, can be used to provide a source of antigen to the cell.
The above examples are provided to illustrate the invention but not to limit its scope. For example, the human terminology for the Major Histocompatibility Complex, namely HLA, is used throughout this document. It is to be appreciated that these principles can be extended to other species as well. Thus, other variants of the invention will be readily apparent to one of ordinary skill in the art and are encompassed by the appended claims. All publications, patents, and patent application cited herein are hereby incorporated by reference for all purposes.
TABLE I
|
|
POSITIONPOSITIONPOSITION
2 (Primary3 (PrimaryC Terminus
Anchor)Anchor)(Primary Anchor)
|
|
SUPERMOTIFS
A1TILVMSFWY
A2LIVMATQIVMATL
A3VSMATLIRK
A24YFWIVLMTFIYWLM
B7PVILFMWYA
B27RHKFYLWMIVA
B44EDFWYLIMVA
B58ATSFWYLIVMA
B62QLIVMPFWYMIVLA
MOTIFS
A1TSMY
A1DEASY
A2.1LMVQIATVLIMAT
A3LMVISATFCGDKYRHFA
A11VTMLISAGNCDFKRYH
A24YFWMFLIW
A*3101MVTALISRK
A*3301MVALFISTRK
A*6801AVTMSLIRK
B*0702PLMFWYAIV
B*3501PLMFWYIVA
B51PLIVFWYAM
B*5301PIMFWYALV
B*5401PATIVLMFWY
|
Bolded residues are preferred, italicized residues are less preferred: A peptide is considered motif-bearing if it has primary anchors at each primary anchor position for a motif or supermotif as specified in the above table.
TABLE Ia
|
|
POSITIONPOSITIONPOSITION
2 (Primary3 (PrimaryC Terminus
Anchor)Anchor)(Primary Anchor)
|
|
SUPERMOTIFS
A1TILVMSFWY
A2VQATVLIMAT
A3VSMATLIRK
A24YFWIVLMTFIYWLM
B7PVILFMWYA
B27RHKFYLWMIVA
B58ATSFWYLIVMA
B62QLIVMPFWYMIVLA
MOTIFS
A1TSMY
A1DEASY
A2.1VQAT*VLIMAT
A3.2LMVISATFCGDKYRHFA
A11VTMLISAGNCDFKRHY
A24YFWFLIW
|
*If 2 is V, or Q, the C-term is not L
|
Bolded residues are preferred, italicized residues are less preferred: A peptide is considered motif-bearing if it has primary anchors at each primary anchor position for a motif or supermotif as specified in the above table.
TABLE II
|
|
POSITION
|
SUPERMOTIFSC-terminus
|
A1
|
A2
|
A3preferred deleteriousDE(3/5); P(5/5)YFW(4/5) DE(4/5)YFW (3/5)YFW (4/5)P (4/5)
|
A24
|
B7preferredFWY(5/5) LIVM(3/5)FWY(4/5)FWY(3/5)
|
deleteriousDE(3/5); P(5/5);DE(3/5)G(4/5)QN(4/5)DE(4/5)
G(4/5); A(315);
QN(3/5)
|
B27
|
B44
|
B58
|
B62
|
POSITION
|
C-terminus
|
POSITION
|
MOTIFSC-terminus
|
A1 9-merpreferredGFYWDEAYFWPDEQNYFW
|
deleteriousDEAGA
|
A1 9-merpreferredGRHKGSTCASTCLIVMDE
|
deleteriousADEPQNRHKPGGP
|
POSITION
|
C-terminus
|
A1 10-merpeferredYFWDEAQNAYFWQNPASTCGDEP
|
deleteriousGPDERHKQNARHKYFWRHKA
|
A1 10-merpreferredYFWSTCLIVMAYFWPGGYFW
|
deleteriousRHKPGPRHKQN
|
A2.1 9-merpreferredYFWYFWSTCYFWAP
|
deleteriousDEPDERKHRKHDERKH
|
A2.1 10-merpreferredAYFWLVIMGG
|
deleteriousDEPDERKHAPRKHRKH
|
POSITION
|
C-terminus
|
A3preferredRHKYFWPRHKYFWAYFWP
|
deleteriousDEPDE
|
A11preferredAYFWYFWAYFWYFWP
|
deleteriousDEPAG
|
A24 9-merpreferredSTCYFWYFW
|
deleteriousDEGDEGQNPDERHKGAQN
|
A24 10-merpreferredPYFWPP
|
deleteriousGDEQNRHKDEAQNDEA
|
POSITION
|
C-terminus
|
A3101preferredRHKYFWPYFWYFWAP
|
deleteriousDEPDEADEDEDEDE
|
A3301preferredYFWAYFW
|
deleteriousGPDE
|
A6801preferredYFWSTCYFWP
|
deleteriousGPDEGRHKA
|
B0702preferredRHKFWYRHKRHKRHKRHKPA
|
deleteriousDEQNPDEPDEDEGDEQNDE
|
B3501preferredFWYLIVMFWYFWY
|
deleteriousAGPGG
|
POSITION
|
C-terminus
|
B51preferredLIVMFWYFWYSTCFWYGFWY
|
deleteriousAGPDERHKSTCDEGDEQN GDE
|
B5301preferredLIVMFWYFWYSTCFWYLIVMFWYFWY
|
deleteriousAGPQNGRHKQNDE
|
B5401preferredFWYFWYLIVMLIVMALIVMFWYAP
|
deleteriousGPQNDEGDESTCRHKDEDEQNDGEDE
|
Italicized residues indicate less preferred or “tolerated” residues.
|
The information in Table II is specific for 9-mers unless otherwise specified.
|
Italicized residues indicate less preferred or “tolerated” residues.
The information in Table II is specific for 9-mers unless otherwise specified.
TABLE III
|
|
POSITION
|
MOTIFS
|
DR4preferredFMYLIVWMTIVSTCPALIMMHMH
deleteriousWRWDE
DR1preferredMFLIVWYPAMQVMATSPLICMAVM
deleteriousCCHFDCWDGDED
DR7preferredMFLIVWYMWAIVMSACTPLMIV(SEQ ID NO:14527)
deleteriousCGGRDNG(SEQ ID NO:14528)
DR SupermotifMFLIVWYVMSTACPLI
|
|
DR3 MOTIFS
|
motif aLIVMFYD
preferred
motif bLIVMFAYDNQESTKRH
preferred
|
Italicized residues indicate less preferred or “tolerated” residues.
|
Italicized residues indicate less preferred or “tolerated” residues.
TABLE IV
|
|
HLA Class I Standard Peptide Binding Affinity.
STANDARD
STANDARDBINDING
ALLELEPEPTIDESEQ IDSEQUENCEAFFINITY (nM)
|
A*0101944.0214492YLEPAIAKY25
|
A*0201941.0114493FLPSDYFPSV5.0
|
A*0202941.0114494FLPSDYFPSV4.3
|
A*0203941.0114495FLPSDYFPSV10
|
A*0205941.0114496FLPSDYFPSV4.3
|
A*0206941.0114497FLPSDYFPSV3.7
|
A*0207941.0114498FLPSDYFPSV23
|
A*68021141.0214499FTQAGYPAL40
|
A*0301941.1214500KVFPYALINK11
|
A*1101940.0614501AVDLYHFLK6.0
|
A*3101941.1214502KVFPYALINK18
|
A*33011083.0214503STLPETYVVRR29
|
A*6801941.1214504KVFPYALINK8.0
|
A*2402979.0214505AYIDNYNKF12
|
B*07021075.2314506APRTLVYLL5.5
|
B*35011021.0514507FPFKYAAAF7.2
|
B511021.0514508FPFKYAAAF5.5
|
B*53011021.0514509FPFKYAAAF9.3
|
B*54011021.0514510FPFKYAAAF10
|
TABLE V
|
|
|
HLA Class II Standard Peptide Binding Affinity.
|
Binding
|
Standard
SEQ
Affinity
|
Allele
Nomenclature
Peptide
ID
Sequence
(nM)
|
|
DRB1*0101
DR1
515.01
14511
PKYVKQNTLKLAT
5.0
|
|
DRB1*0301
DR3
829.02
14512
YKTIAFDEEARR
300
|
|
DRB1*0401
DR4w4
515.01
14513
PKYVKQNTLKLAT
45
|
|
DRB1*0404
DR4w14
717.01
14514
YARFQSQTTLKQKT
50
|
|
DRB1*0405
DR4w15
717.01
14515
YARFQSQTTLKQKT
38
|
|
DRB1*0701
DR7
553.01
14516
QYIKANSKFIGITE
25
|
|
DRB1*0802
DR8w2
553.01
14517
QYIKANSKFIGITE
49
|
|
DRB1*0803
DR8w3
553.01
14518
QYTKANSKFIGITE
1600
|
|
DRB1*0901
DR9
553.01
14519
QYIKANSKFIGITE
75
|
|
DRB1*1101
DR5w11
553.01
14520
QYIKANSKFIGITE
20
|
|
DRB1*1201
DRSw12
1200.05
14521
EALIHQLKINPYVLS
298
|
|
DRB1*1302
DR6w19
650.22
14522
QYIKANAKFIGITE
3.5
|
|
DRB1*1501
DR2w2β1
507.02
14523
GRTQDENPVVHFFK
9.1
|
NIVTPRTPPP
|
|
DRB3*0101
DR52a
511
14524
NGQIGNDPNRDIL
470
|
|
DRB4*0101
DRw53
717.01
14525
YARFQSQTTLKQKT
58
|
|
DRB5*0101
DR2w2β2
553.01
14526
QYIKANSKFIGITE
20
|
|
The “Nomenclature” column lists the allelic designations used in Tables XIX and XX.
TABLE VI
|
|
Allelle-specific HLA-supertype members
HLA-supertypeVerifiedaPredictedb
|
A1A*0101, A*2501, A*2601, A*2602, A*3201A*0102, A*2604, A*3601, A*4301, A*8001
A2A*0201, A*0202, A*0203, A*0204, A*0205,A*0208, A*0210, A*0211, A*0212, A*0213
A*0206, A*0207, A*0209, A*0214, A*6802, A*6901
A3A*0301, A*1101, A*3101, A*3301, A*6801A*0302, A*1102, A*2603, A*3302, A*3303, A*3401,
A*3402, A*6601, A*6602, A*7401
A24A*2301, A*2402, A*3001A*2403, A*2404, A*3002, A*3003
B7B*0702, B*0703, B*0704, B*0705, B*1508, B*3501,B*1511, B*4201, B*5901
B*3502, B*3503, B*3504, B*3505, B*3506, B*3507,
B*3508, B*5101, B*5102, B*5103, B*5104, B*5105,
B*5301, B*5401, B*5501, B*5502, B*5601, B*5602,
B*6701, B*7801
B27B*1401, B*1402, B*1509, B*2702, B*2703, B*2704,B*2701, B*2707, B*2708, B*3802, B*3903, B*3904,
B*2705, B*2706, B*3801, B*3901, B*3902, B*7301B*3905, B*4801, B*4802, B*1510, B*1518, B*1503
B44B*1801, B*1802, B*3701, B*4402, B*4403, B*4404,B*4101, B*4501, B*4701, B*4901, B*5001
B*4001, B*4002, B*4006
B58B*5701, B*5702, B*5801, B*5802, B*1516, B*1517
B62B*1501, B*1502, B*1513, B*5201B*1301, B*1302, B*1504, B*1505, B*1506, B*1507,
B*1515, B*1520, B*1521, B*1512, B*1514, B*1510
|
aVerified alleles include alleles whose specificity has been determined by pool sequencing analysis, peptide binding assays, or by analysis of the sequences of CTL epitopes.
|
bPredicted alleles are alleles whose specificity is predicted on the basis of B and F pocket structure to overlap with the supertype specificity.
|
TABLE VII
|
|
|
HIV A01 Super Motif Peptides with Binding
|
Information
|
Con-
|
Se-
ser-
|
Po-
No. of
quence
van-
SEQ
|
Pro-
si-
Amino
Fre-
cy
ID
|
tein
Sequence
tion
Acids
quency
(%)
A*0101
NO
|
|
ENV
KLWVTVYY
44
8
11
17
1
|
|
ENV
NLWVTVYY
44
8
35
56
2
|
|
ENV
DTEVIINVW
75
8
19
30
3
|
|
ENV
VTENFNMW
102
8
34
53
4
|
|
ENV
RIGPGQTF
357
8
11
17
5
|
|
ENV
GIGPGQTF
360
8
01
33
6
|
|
ENV
SIGSGQAF
360
8
01
33
7
|
|
ENV
KLREIRQF
405
8
01
25
8
|
|
ENV
STNGTETF
537
8
01
17
9
|
|
ENV
AVGIGAVF
595
8
11
17
10
|
|
ENV
IILLKLTVW
650
8
13
20
11
|
|
ENV
IILLQLTVW
650
8
34
53
12
|
|
ENV
HMLQLTVW
650
8
10
16
13
|
|
ENV
RVLAVERY
665
8
33
52
14
|
|
ENV
NVPWNSSW
693
8
13
20
15
|
|
ENV
EIWDNMTW
716
8
13
20
16
|
|
ENV
DLLALDKW
754
8
21
33
17
|
|
ENV
ELLELDKW
754
8
20
31
18
|
|
ENV
DITNWLWY
769
8
10
16
19
|
|
ENV
WLWYIKIF
773
8
50
78
20
|
|
ENV
LIGLRIIF
787
8
16
25
21
|
|
ENV
LIGLRIVF
787
8
29
45
22
|
|
ENV
SIRLVNGF
842
8
13
20
23
|
|
ENV
SIRLVSGF
842
8
13
20
24
|
|
ENV
DLRNLCLF
856
8
17
27
25
|
|
ENV
DLRSLCLF
856
8
38
59
26
|
|
ENV
RSLCLFSY
858
8
35
55
27
|
|
ENV
ELLGRRGW
881
8
31
37
28
|
|
ENV
TVYYGVPVW
48
9
55
86
29
|
|
ENV
NVTENFNMW
101
9
34
53
30
|
|
ENV
DSSNSTGNY
218
9
01
20
31
|
|
ENV
ILKCNDKKF
271
9
12
19
32
|
|
ENV
RIGPGQTFY
357
9
11
17
33
|
|
ENV
GIGPGQTFY
360
9
01
33
34
|
|
ENV
SIGSGQAFY
360
9
01
33
35
|
|
ENV
DLEITTIISF
428
9
21
33
36
|
|
ENV
IISFNCGGEF
434
9
36
56
37
|
|
ENV
HSFNCRGEF
434
9
16
25
38
|
|
ENV
RIKQIINMW
488
9
30
47
39
|
|
ENV
RIKQIVNMW
488
9
12
19
40
|
|
ENV
GSENGTETF
538
9
02
18
41
|
|
ENV
GIGAVFLGF
598
9
11
18
42
|
|
ENV
MLGAMFLGF
599
9
04
36
43
|
|
ENV
TIGAMFLGF
599
9
03
27
44
|
|
ENV
LICTTAVPW
688
9
19
30
45
|
|
ENV
LICTTNVPW
688
9
17
27
46
|
|
ENV
LICTTTVPW
688
9
12
19
47
|
|
ENV
ALDKWASLW
757
9
11
17
48
|
|
ENV
ELDKWASLW
757
9
18
28
49
|
|
ENV
GLIGLRIIF
786
9
15
23
50
|
|
ENV
GLIGLRIVF
786
9
29
45
51
|
|
ENV
IVNRVRQGY
799
9
38
59
52
|
|
ENV
RSIRLVNGF
841
9
12
19
53
|
|
ENV
RSIRLVSGF
841
9
13
20
54
|
|
ENV
VSGFLALAW
846
9
16
25
55
|
|
ENV
FSYIIRLRDF
863
9
18
28
56
|
|
ENV
SLKGLRLGW
889
9
11
39
57
|
|
ENV
SLRGLQRGW
889
9
05
18
58
|
|
ENV
RLGWEGLKY
894
9
09
29
59
|
|
ENV
VTVYYGVPVW
47
10
55
86
60
|
|
ENV
QMIIEDIISLW
116
10
29
45
61
|
|
ENV
ITQACPKVSF
245
10
29
45
62
|
|
ENV
VSFEPIPIIIY
253
10
28
44
63
|
|
ENV
PIIIYCAPAGF
260
10
27
42
64
|
|
ENV
PIIIYCTPAGF
260
10
10
16
65
|
|
ENV
AILKCNDKKF
270
10
12
19
66
|
|
ENV
NTSPRSRVAY
376
10
01
33
67
|
|
ENN
IISFNCGGEFF
434
10
35
55
68
|
|
ENV
IISFNCRGEFF
434
10
16
25
69
|
|
ENV
NTETNKTETF
537
10
01
17
70
|
|
ENV
NTTGNTTETF
537
10
01
17
71
|
|
ENV
KLICTTAVPW
687
10
19
30
72
|
|
ENV
KLICTTNVPW
687
10
17
27
73
|
|
ENV
KLICTTTVPW
687
10
12
19
74
|
|
ENV
TTNVPWNSS
691
10
11
17
75
|
|
ENV
SIVNRVRQGY
798
10
36
56
76
|
|
ENV
LVSGFLALAW
845
10
16
25
77
|
|
ENV
DLRNLCLFSY
856
10
16
25
78
|
|
ENV
DLRSLCLFSY
856
10
35
55
79
|
|
ENV
IVELLGRRGW
879
10
22
34
80
|
|
ENV
SSLKGLRLGW
886
10
10
16
81
|
|
ENV
WVTVYYGVPV
46
11
55
86
82
|
|
ENV
PVWKIEATTTL
54
11
22
34
83
|
|
ENV
TLFCASDAKA
64
11
40
63
84
|
|
ENV
VITQACPKVSF
244
11
14
22
85
|
|
ENV
KVSFEPIPIIIY
252
11
28
44
86
|
|
ENV
GTAGNSSRAA
375
11
01
33
87
|
|
ENV
TTHSFNCGGE
432
11
16
25
88
|
|
ENV
TTIISFNCRGE
432
11
12
19
89
|
|
ENV
VMIISFNCGGE
432
11
13
20
90
|
|
ENV
IISFNCGGEFFY
434
11
35
55
91
|
|
ENV
IISFNCRGEFFY
434
11
16
25
92
|
|
ENV
NMWQEYGKA
494
11
15
23
93
|
|
ENV
DMRDNWRSEL
552
11
37
58
94
|
|
ENV
AVGIGAVFLGF
595
11
11
17
95
|
|
ENV
YLKDQQLLGI
672
11
27
42
96
|
|
ENV
YLRDQQLLGI
672
11
18
28
97
|
|
ENV
CTTNVPWNSS
690
11
11
17
98
|
|
ENV
WMEWEREIDN
723
11
10
16
99
|
|
ENV
LLALDKWASL
755
11
11
17
100
|
|
ENV
LLELDKWASL
755
11
18
28
101
|
|
ENV
ALDKWASLW
757
11
10
16
102
|
|
ENV
ELDKWASLWN
757
11
16
25
103
|
|
ENV
ISNWLWYIKIF
770
11
11
17
104
|
|
ENV
ITKWLWYIKIF
770
11
12
19
105
|
|
ENV
ITNWLWYIKIF
770
11
14
22
106
|
|
ENV
LSIVNRVRQGY
797
11
34
53
107
|
|
ENV
RVRQGYSPLSF
802
11
47
73
108
|
|
ENV
RLVSGFLALA
844
11
16
25
109
|
|
ENV
CLFSYIIRLRDF
861
11
18
28
110
|
|
ENV
RIVELLGRRG
878
11
22
34
111
|
|
ENV
GLRLGWEGLK
892
11
09
29
112
|
|
ENV
RLGWEGLKYL
894
11
07
23
113
|
|
GAG
ASRELERF
38
8
46
72
114
|
|
GAG
SSQVSQNY
145
8
15
31
115
|
|
GAG
KVIEEKAF
178
8
24
38
116
|
|
GAG
KVVEEKAF
178
8
28
44
117
|
|
GAG
TLQEQIAW
263
8
12
19
118
|
|
GAG
TLQEQIGW
263
8
27
42
119
|
|
GAG
PIPVGDIY
279
8
11
17
120
|
|
GAG
PIPVGEIY
279
8
35
55
121
|
|
GAG
ASQEVKNW
333
8
11
17
122
|
|
GAG
ATQDVKNW
333
8
15
23
123
|
|
GAG
ATQEVKNW
333
8
18
28
124
|
|
GAG
IMMQKSNF
408
8
11
17
125
|
|
GAG
IMMQRGNF
408
8
27
42
126
|
|
GAG
CTERQANF
459
8
55
87
127
|
|
GAG
ETIDKDLY
537
8
01
25
128
|
|
GAG
LTSLKSLF
549
8
13
20
129
|
|
GAG
LTSLRSLF
549
8
12
19
130
|
|
GAG
LSGGKLDAW
8
9
16
25
131
|
|
GAG
GSEELRSLY
73
9
12
19
132
|
|
GAG
NSSQVSQNY
144
9
14
31
133
|
|
GAG
ISPRTLNAW
168
9
36
56
134
|
|
GAG
LSPRTLNAW
168
9
17
27
135
|
|
GAG
FSPEVIPMF
185
9
54
84
136
|
|
GAG
TINEEAAEW
225
9
53
83
137
|
|
GAG
STLQEQIAW
262
9
12
19
138
|
|
GAG
STLQEQIGW
262
9
27
42
139
|
|
GAG
PVGDIYKRW
281
9
18
28
140
|
|
GAG
PVGEIYKRW
281
9
40
63
141
|
|
GAG
GLNKIVRMY
293
9
60
94
0.0017
142
|
|
GAG
NIMMQRGNF
407
9
10
17
143
|
|
GAG
TIMMQRGNF
407
9
13
22
144
|
|
GAG
SSKGRPGNF
476
9
11
18
145
|
|
GAG
PTAPPAESF
495
9
20
31
146
|
|
GAG
PTAPPEESF
495
9
15
23
147
|
|
GAG
PTAPPAESF
507
9
02
67
148
|
|
GAG
PTAPPPESF
507
9
01
33
149
|
|
GAG
PLASLKSLF
548
9
15
23
150
|
|
GAG
PLTSLKSLF
548
9
12
19
151
|
|
GAG
PLTSLRSLF
548
9
12
19
152
|
|
GAG
VLSGGKLDAW
7
10
15
23
153
|
|
GAG
RLRPGGKKKY
20
10
34
53
154
|
|
GAG
SLFNTVATLY
79
10
15
23
155
|
|
GAG
SLYNTYATLY
79
10
22
34
156
|
|
GAG
AISPRTLNAW
167
10
29
45
157
|
|
GAG
ALSPRTLNAW
167
10
10
16
158
|
|
GAG
WVKVIEEKAF
176
10
24
38
159
|
|
GAG
WVKVVEEKAF
176
10
28
44
160
|
|
GAG
DTINEEAAEW
224
10
31
48
161
|
|
GAG
ETINEEAAEW
224
10
22
34
162
|
|
GAG
TSTLQEQIAW
261
10
12
19
163
|
|
GAG
TSTLQEQIGW
261
10
27
42
164
|
|
GAG
DIKQGPKEPF
308
10
19
30
165
|
|
GAG
DIRQGPKEPF
308
10
41
64
166
|
|
GAG
ATIMMQRGNF
406
10
11
28
167
|
|
GAG
PSIIKGRPGNF
475
10
23
36
168
|
|
GAG
PSNKGRPGNF
475
10
14
22
169
|
|
GAG
PSSKGRPGNF
475
10
11
17
170
|
|
GAG
SVLSGGKLDA
6
11
15
23
171
|
|
GAG
IVWASRELERF
35
11
19
30
172
|
|
GAG
LVWASRELER
35
11
25
39
173
|
|
GAG
RSLYNTVATL
78
11
15
24
174
|
|
GAG
TTSTLQEQIA
260
11
11
17
175
|
|
GAG
TTSTLQEQIG
260
11
27
43
176
|
|
GAG
PIPVGEIYKRW
279
11
34
53
177
|
|
GAG
ILGLNKIVRMY
291
11
57
89
178
|
|
GAG
ASAQQDLKGG
392
11
01
50
179
|
|
GAG
ATAQQDLKGG
392
11
01
50
180
|
|
GAG
PTAPPAESFGF
495
11
10
16
181
|
|
GAG
PTAPPEESFRF
495
11
14
22
182
|
|
GAG
PTAPPAESFRF
507
11
02
67
183
|
|
GAG
PTAPPPESFRF
507
11
01
33
184
|
|
NEF
ATNADCAW
71
8
12
22
185
|
|
NEF
PMTYKGAF
105
8
12
19
186
|
|
NEF
DILDLWVY
185
8
20
31
187
|
|
NEF
EILDLWVY
185
8
33
52
188
|
|
NEF
WVYHTQGF
191
8
13
20
189
|
|
NEF
WVYIITQGY
191
8
21
33
190
|
|
NEF
GIRYPLTF
213
8
13
20
191
|
|
NEF
GTRFPLTF
213
8
13
20
192
|
|
NEF
PLTFGWCF
219
8
43
67
193
|
|
NEF
WSKSSIVGW
5
9
20
31
194
|
|
NEF
QVPLRPMTF
100
9
10
16
195
|
|
NEF
QVPLRPMTY
100
9
46
72
0.0008
196
|
|
NEF
WVYIITQGFF
191
9
13
20
197
|
|
NEF
WVYHTQGYF
191
9
21
33
198
|
|
NEF
HTQGFFPDW
194
9
14
22
199
|
|
NEF
HTQGYFPDW
194
9
25
39
200
|
|
NEF
NTQGYFPDW
194
9
12
19
201
|
|
NEF
YTPGPGIRY
207
9
17
27
202
|
|
NEF
YTPGPGTRF
207
9
13
20
203
|
|
NEF
DLWVYIITQGF
188
10
13
20
204
|
|
NEF
DLWVYIITQGY
188
10
21
33
205
|
|
NEF
GIRYPLTFGW
213
10
13
20
206
|
|
NEF
GTRFPLTFGW
213
10
12
19
207
|
|
NEF
IIMARELIIPEY
320
10
10
16
208
|
|
NEF
NTAATNADCA
68
11
12
19
209
|
|
NEF
PLRPMTYKGA
102
11
12
19
210
|
|
NEF
DLWVYIITQGF
188
11
13
20
211
|
|
NEF
DLWVYIITQGY
188
11
21
33
212
|
|
NEF
IIMARELIIPEY
320
11
10
16
213
|
|
POL
DINLPGKW
122
8
13
20
214
|
|
POL
EINLPGKW
122
8
12
19
215
|
|
POL
MIGGIGGF
133
8
62
97
216
|
|
POL
QIGCTLNF
179
8
41
64
217
|
|
POL
QLGCTLNF
179
8
16
25
218
|
|
POL
KIGPENPY
238
8
51
80
219
|
|
POL
RIGPENPY
238
8
11
17
220
|
|
POL
VLDVGDAY
297
8
60
94
221
|
|
POL
SVPLDKDF
306
8
18
28
222
|
|
POL
MTKILEPF
353
8
44
69
223
|
|
POL
QLPIEKDSW
434
8
13
20
224
|
|
POL
VLPEKDSW
434
8
13
20
225
|
|
POL
KLVGKLNW
448
8
62
97
226
|
|
POL
ATESIVIW
568
8
19
30
227
|
|
POL
ETWWTDYW
591
8
10
16
228
|
|
POL
PIVGAETF
625
8
28
44
229
|
|
POL
IVGAETFY
626
8
28
44
230
|
|
POL
KIELQAIY
668
8
12
19
231
|
|
POL
NIVTDSQY
686
8
62
97
232
|
|
POL
LIKKEKVY
717
8
35
55
233
|
|
POL
AVIIVASGY
828
8
59
92
234
|
|
POL
ETGQETAY
844
8
59
92
235
|
|
POL
ILKLAGRW
853
8
34
53
236
|
|
POL
LLKLAGRW
853
8
25
39
237
|
|
POL
IITDNGSNF
866
8
51
80
238
|
|
POL
TTVKAACW
876
8
15
23
239
|
|
POL
AVKAACWW
877
8
32
50
240
|
|
POL
TVKAACWW
877
8
24
38
241
|
|
POL
QIIKIQNF
968
8
12
19
242
|
|
POL
QITKIQNF
968
8
35
55
243
|
|
POL
KIQNFRVY
971
8
52
81
244
|
|
POL
PTRRELQVW
30
9
13
20
245
|
|
POL
FSFPQITLW
85
9
14
22
246
|
|
POL
KMIGGIGGF
132
9
62
97
247
|
|
POL
ELNKRTQDF
268
9
57
89
248
|
|
POL
TVLDVGDAY
296
9
57
89
0.0180
249
|
|
POL
VLDVGDAYF
297
9
60
94
250
|
|
POL
FSVPLDKDF
305
9
18
28
251
|
|
POL
PLDKDFRKY
308
9
19
30
252
|
|
POL
ETPGIRYQY
327
9
52
81
0.0052
253
|
|
POL
SMTKILEPF
352
9
43
67
254
|
|
POL
ELREIILLKW
393
9
17
27
255
|
|
POL
ELRQIILLRW
393
9
15
23
256
|
|
POL
IVLPEKDSW
433
9
13
20
257
|
|
POL
KLNWASQIY
452
9
60
94
0.0070
258
|
|
POL
VIWGKTPKF
573
9
47
73
259
|
|
POL
KLPIQKETW
582
9
20
31
260
|
|
POL
RLPIQKETW
582
9
26
41
261
|
|
POL
WTDYWQATW
594
9
14
22
262
|
|
POL
WTEYWQATW
594
9
24
38
263
|
|
POL
ATWIPEWEF
600
9
52
81
264
|
|
POL
NTPPLVKLW
610
9
57
89
265
|
|
POL
PIVGAETFY
625
9
28
44
0.0007
266
|
|
POL
ETKLGKAGY
641
9
35
55
0.0010
267
|
|
POL
QLIKKEKVY
716
9
28
44
0.0007
268
|
|
POL
SSGIRKVLF
745
9
26
41
269
|
|
POL
QVDCSVGIW
805
9
57
89
270
|
|
POL
ETGQETAYF
844
9
57
89
271
|
|
POL
FILKLAGRW
852
9
32
50
272
|
|
POL
FLLKLAGRW
852
9
25
39
273
|
|
POL
STTVKAACW
875
9
15
23
274
|
|
POL
TTVKAACWW
876
9
15
23
275
|
|
POL
KTAVQMAYF
925
9
57
89
276
|
|
POL
QMAVFIIINF
929
9
60
94
277
|
|
POL
KIQNFRVYY
971
9
52
81
0.0056
278
|
|
POL
LTQIGCTLNF
177
10
41
64
279
|
|
POL
LTQLGCTLNF
177
10
15
23
280
|
|
POL
GMDGPKVKQ
201
10
51
80
281
|
|
POL
ISKIGPENPY
236
10
42
66
0.0130
282
|
|
POL
ISRIGPENPY
236
10
11
17
283
|
|
POL
AIKKKDSTKW
251
10
57
89
284
|
|
POL
STKWRKLVDF
257
10
58
91
285
|
|
POL
ELNKRTQDFW
268
10
57
89
286
|
|
POL
VTVLDVGDAY
295
10
56
88
0.2800
287
|
|
POL
TVLDVGDAYF
296
10
57
89
288
|
|
POL
SSMTKILEPF
351
10
33
52
289
|
|
POL
VIYQYMDDLY
368
10
51
80
0.2500
290
|
|
POL
PIQLVEKDSW
432
10
13
20
291
|
|
POL
PIVLVEKDSW
432
10
13
20
292
|
|
POL
ILKEVYIIGVY
498
10
40
63
0.0017
293
|
|
POL
EIQKQCQDQW
520
10
13
20
294
|
|
POL
EIQKQGQCQW
520
10
15
23
295
|
|
POL
WTYQIYQEPF
529
10
42
66
296
|
|
POL
KIATESIVIW
566
10
14
22
297
|
|
POL
IVIWGKTPKF
572
10
47
73
298
|
|
POL
PIQKETWEAW
584
10
15
23
299
|
|
POL
PIQKETWETW
584
10
27
42
300
|
|
POL
ETWETWWTD
588
10
10
16
301
|
|
POL
ETWETWWTE
588
10
10
16
302
|
|
POL
NTPPLVKLWY
610
10
57
89
0.0041
303
|
|
POL
EVNIVTDSQY
684
10
59
92
0.0530
304
|
|
POL
VSAGIRKVLF
744
10
15
23
305
|
|
POL
VSSGIRKVLF
744
10
26
41
306
|
|
POL
LVAVIIVASGY
826
10
53
83
0.0390
307
|
|
POL
TIIITDNGSNF
864
10
14
22
308
|
|
POL
VIIITDNGSNF
864
10
24
38
309
|
|
POL
TSAAVKAACW
874
10
27
42
310
|
|
POL
TSTTVKAACW
874
10
14
22
311
|
|
POL
STTVKAACW
875
10
15
23
312
|
|
POL
GIKQEFGIPY
886
10
22
34
0.0010
313
|
|
POL
GIQQEFGIPY
886
10
11
17
314
|
|
POL
IIKIQNFRVY
969
10
12
19
315
|
|
POL
ITKIQNFRVY
969
10
36
57
0.0010
316
|
|
POL
NSPTRRELQV
28
11
12
19
317
|
|
POL
VSFSFPQITLW
78
11
07
15
318
|
|
POL
GTTLNPPQITF
79
11
01
17
319
|
|
POL
PSLSFPQITLW
79
11
02
33
320
|
|
POL
GTLNCPQITL
80
11
01
33
321
|
|
POL
PTFNFPQITLW
80
11
01
33
322
|
|
POL
SSFSFPQITLW
82
11
03
30
323
|
|
POL
VLEDINLPGKW
119
11
13
20
324
|
|
POL
VLEEINLPGKW
119
11
12
19
325
|
|
POL
GIGGFIKVRQY
136
11
53
83
326
|
|
POL
LLTQIGCTLNF
176
11
21
33
327
|
|
POL
MLTQIGCTLNF
176
11
17
27
328
|
|
POL
MLTQLGCTLN
176
11
10
16
329
|
|
POL
KISKIGPENPY
235
11
41
64
330
|
|
POL
KISRIGPENPY
235
11
11
17
331
|
|
POL
DSTKWRKLVD
256
11
58
91
332
|
|
POL
SVTVLDVGDA
294
11
56
88
333
|
|
POL
VTVLDVGDAY
295
11
56
88
334
|
|
POL
SVPLDKDFRK
306
11
18
28
335
|
|
POL
SINNETPGIRY
323
11
32
50
336
|
|
POL
STNNETPGIRY
323
11
11
17
337
|
|
POL
QSSMTKILEPF
350
11
33
52
338
|
|
POL
IVIYQYMDDLY
367
11
42
66
339
|
|
POL
ELREHLLKWG
393
11
14
22
340
|
|
POL
ELRQHLLRWG
393
11
12
19
341
|
|
POL
WMGYELHPDK
418
11
60
94
342
|
|
POL
DIQKLVGKLN
445
11
62
97
343
|
|
POL
EILKEPVIIGVY
497
11
40
63
344
|
|
POL
ILKEPVIIGVYY
498
11
38
59
345
|
|
POL
SIVIWGKTPKF
571
11
41
64
346
|
|
POL
PIQKETWEAW
584
11
15
23
347
|
|
POL
PIQKETWETW
584
11
27
42
348
|
|
POL
ETWETWWTD
588
11
10
16
349
|
|
POL
FVNTPPLVKL
608
11
54
86
350
|
|
POL
LIKKEKVYLA
717
11
20
31
351
|
|
POL
LIKKEKVYLSW
717
11
13
20
352
|
|
POL
LVSAGIRKVLF
743
11
15
23
353
|
|
POL
LVSSGIRKVLF
743
11
26
41
354
|
|
POL
IISNWRAMAS
768
11
32
50
355
|
|
POL
ILVAVIIVASGY
825
11
53
83
356
|
|
POL
KVIIITDNGSNF
863
11
21
33
357
|
|
POL
FTSAAVKAAC
873
11
27
42
358
|
|
POL
FTSTTVKAAC
873
11
14
22
359
|
|
POL
TSAAVKAACW
874
11
27
42
360
|
|
POL
TSTTVKAACW
874
11
14
22
361
|
|
POL
IILKTAVQMAV
923
11
57
89
362
|
|
POL
AVQMAVFIIIN
927
11
60
94
363
|
|
POL
QIIKIQNFRVY
968
11
12
19
364
|
|
POL
QITKIQNFRVY
968
11
35
55
365
|
|
POL
IIKIQNFRVYY
969
11
12
19
366
|
|
POL
ITKIQNFRVYY
969
11
36
57
0.0110
367
|
|
POL
PIWKGPAKLL
985
11
35
55
368
|
|
POL
PLWKGPAKLL
985
11
18
28
369
|
|
REV
ILYQSNPY
23
8
27
42
370
|
|
REV
AVRIIKILY
17
9
13
20
371
|
|
REV
KILYQSNPY
22
9
26
41
372
|
|
REV
IIKILYQSNPY
20
11
18
28
373
|
|
TAT
PVDPNLEPW
3
9
20
31
374
|
|
TAT
PVDPRLEPW
3
9
14
22
375
|
|
TAT
FLNKGLGISY
41
10
14
22
376
|
|
VIF
SLVKIIIIMY
23
8
44
69
377
|
|
VIF
RLVITTYW
65
8
12
19
378
|
|
VIF
QLIIILYYF
110
8
14
22
379
|
|
VIF
QLIIIMIIYF
110
8
14
22
380
|
|
VIF
IILYYFDCF
113
8
16
25
381
|
|
VIF
IIMHYFDCF
113
8
15
23
382
|
|
VIF
IVSPRCEY
133
8
14
22
383
|
|
VIF
KSLVKIIIIMY
22
9
18
28
384
|
|
VIF
NSLVKIIIIMY
22
9
24
38
385
|
|
VIF
GLIITGERDW
73
9
22
34
386
|
|
VIF
GLQTGERDW
73
9
12
19
387
|
|
VIF
SIEWRLRRY
89
9
11
17
388
|
|
VIF
QVDRMKIRTW
12
10
12
19
389
|
|
VIF
QVDRMRINTW
12
10
10
16
390
|
|
VIF
QVDRMRIRTW
12
10
31
48
391
|
|
VIF
IILGHGVSIEW
83
10
25
39
392
|
|
VIF
IILGQGVSIEW
83
10
26
41
393
|
|
VIF
VSIEWRLRRY
88
10
11
7
394
|
|
VIF
LIIILYYFDCF
111
10
16
25
395
|
|
VIF
LIIIMIIYFDCF
111
10
15
23
396
|
|
VIF
SVKKLTEDRW
174
10
13
20
397
|
|
VIF
GVSIEWRLRR
87
11
10
16
398
|
|
VIF
GLADQLIHMH
106
11
11
17
399
|
|
VIF
QLIHLYYFDCF
110
11
13
20
400
|
|
VIF
QLIIIMHYFDCF
110
11
14
22
401
|
|
VIF
PSVKKLTEDR
173
11
13
20
402
|
|
VPR
KSEAVRHF
27
8
15
23
403
|
|
VPR
WLIIGLGQY
38
8
11
17
404
|
|
VPR
RILQQLLF
62
8
45
70
405
|
|
VPR
AVRIlFPRIW
30
9
14
22
406
|
|
VPR
AVRIIFPRPW
30
9
34
53
407
|
|
VPR
ELKNEAVRIIF
25
10
17
27
408
|
|
VPR
ELKSEAVRIIF
25
10
15
23
409
|
|
VPR
WLIIGLGQIIIY
38
10
20
31
410
|
|
VPR
IIIYETYGDTW
45
10
17
27
411
|
|
VPR
IIIYNTYGDTW
45
10
14
22
412
|
|
VPR
YIYETYGDTW
45
10
14
22
413
|
|
VPR
IIRILQQLLF
60
10
41
64
414
|
|
VPR
ILQQLLFIIIF
63
10
35
55
415
|
|
VPR
AIIRILQQLLF
59
11
38
59
416
|
|
VPR
RILQQLLFIIIF
62
11
34
53
417
|
|
VPU
LIIAIVVW
26
8
10
16
418
|
|
VPU
IVVWTIVF
30
8
15
23
419
|
|
VPU
WTIVFIEY
34
8
12
19
420
|
|
VPU
EMGIIIIAPW
89
8
11
17
421
|
|
VPU
AIVVWTIVF
29
9
14
22
422
|
|
VPU
VVWTIVFIEY
31
10
12
19
423
|
|
VPU
GVEMGIIIIAP
91
10
01
50
424
|
|
VPU
KVDYRIVIVAF
7
11
01
33
425
|
|
VPU
IVVWTIVFIEY
30
11
12
19
426
|
|
VPU
RIKEIRDDSDY
64
11
01
50
427
|
|
VPU
RIREIRDDSDY
64
11
01
50
428
|
|
TABLE VIII
|
|
|
HIV A02 Super Motif Peptides with Binding Information
|
SEQ
|
No. of
Sequence
Conservancy
ID
|
Protein
Sequence
Position
Amino Acids
Frequency
(%)
A*0201
A*0202
A*0203
A*0206
A*6802
NO
|
|
ENV
LILGLVII
21
8
09
15
429
|
|
ENV
GLVIICSA
28
8
10
16
430
|
|
ENV
GMLMICSA
28
8
12
19
431
|
|
ENV
QLYATVYA
34
8
01
50
432
|
|
ENV
WVTVYYGV
46
8
58
91
433
|
|
ENV
TVYYGVPV
48
8
55
86
434
|
|
ENV
GVPVWKEA
52
8
34
53
435
|
|
ENV
PVWKEATT
54
8
22
34
436
|
|
ENV
ATTTLFCA
59
8
24
38
437
|
|
ENV
TLFCASDA
64
8
54
84
438
|
|
ENV
EVHNVWAT
77
8
36
56
439
|
|
ENV
ATHACVPT
83
8
56
88
440
|
|
ENV
NVTENFNM
101
8
34
53
441
|
|
ENV
NMWKNDMV
107
8
12
19
442
|
|
ENV
NMWKNNMV
107
8
34
53
443
|
|
ENV
EQMIIEDII
115
8
24
38
444
|
|
ENV
DQSLKPCV
126
8
50
78
445
|
|
ENV
SLKPCVKL
128
8
55
86
446
|
|
ENV
KLTPLCVT
134
8
53
83
447
|
|
ENV
LTPLCVTL
135
8
54
84
448
|
|
ENV
VTSTGNSA
161
8
01
20
449
|
|
ENV
ALFYKLDV
202
8
10
16
450
|
|
ENV
ALFYRLDV
202
8
12
19
451
|
|
ENV
NISPKNNT
217
8
01
33
452
|
|
ENV
LINCNTSA
237
8
17
27
453
|
|
ENV
NTSAITQA
241
8
14
22
454
|
|
ENV
NTSVITQA
241
8
13
20
455
|
|
ENV
ITQACPKV
245
8
37
58
456
|
|
ENV
PIPIIIYCA
258
8
40
63
457
|
|
ENV
PIPIHYCT
258
8
18
28
458
|
|
ENV
PIHYCAPA
260
8
37
58
459
|
|
ENV
PIIIYCTPA
260
8
18
28
460
|
|
ENV
CAPAGFAI
264
8
29
45
461
|
|
ENV
CTPAGFAI
264
8
10
16
462
|
|
ENV
GTGPCKNV
281
8
17
27
463
|
|
ENV
NVSTVQCT
287
8
51
80
464
|
|
ENV
TVQCTIIGI
290
8
51
80
465
|
|
ENV
CTIIGIKPV
294
8
33
52
466
|
|
ENV
CTIIGIRPV
294
8
26
41
467
|
|
ENV
GIKPVVST
297
8
33
52
468
|
|
ENV
GIRPVVST
297
8
26
41
469
|
|
ENV
PVVSTQLL
300
8
60
94
470
|
|
ENV
VVSTQLLL
301
8
60
94
471
|
|
ENV
QLLLNGSL
305
8
57
89
472
|
|
ENV
LLLNGSLA
306
8
55
86
473
|
|
ENV
SLAEEEVV
311
8
14
22
474
|
|
ENV
LAEEEVVI
312
8
13
20
475
|
|
ENV
IIRSENLT
319
8
10
16
476
|
|
ENV
CTRPNNNT
345
8
29
45
477
|
|
ENV
NTRKSIRI
351
8
10
16
478
|
|
ENV
NTSPRSRV
376
8
01
33
479
|
|
ENV
TAGNSSRA
376
8
01
33
480
|
|
ENV
IIGDIRQA
377
8
30
49
481
|
|
ENV
MQNGTNIT
458
8
01
17
482
|
|
ENV
IITEGNITL
478
8
01
50
483
|
|
ENV
NITLPCRI
482
8
11
17
484
|
|
ENV
TITLPCRI
482
8
14
22
485
|
|
ENV
RIKQIINM
488
8
30
47
486
|
|
ENV
RIKQIVNM
488
8
12
19
487
|
|
ENV
IINMWQEV
492
8
17
27
488
|
|
ENV
WQEVGKAM
496
8
18
28
489
|
|
ENV
WQRVGQAM
496
8
11
17
490
|
|
ENV
EVGKAMYA
498
8
18
28
491
|
|
ENV
RVGQAMYA
498
8
10
16
492
|
|
ENV
KAMYAPPI
502
8
23
36
493
|
|
ENV
QAMYAPPI
502
8
14
22
494
|
|
ENV
RAMYAPPI
502
8
12
19
495
|
|
ENV
QIRCSSNI
512
8
11
17
496
|
|
ENV
NITGLILT
519
8
11
17
497
|
|
ENV
NITGLLLT
519
8
35
55
498
|
|
ENV
ELYKYKVV
560
8
56
89
499
|
|
ENV
KVVKIEPL
565
8
25
39
500
|
|
ENV
KIEPLGVA
568
8
23
37
501
|
|
ENV
PTKAKRRV
576
8
22
34
502
|
|
ENV
VVEREKRA
588
8
32
50
503
|
|
ENV
VVQREKRA
588
8
17
27
504
|
|
ENV
VQREKRAV
589
8
17
27
505
|
|
ENV
RAVGIGAV
594
8
12
19
506
|
|
ENV
GALFLGFL
601
8
12
19
507
|
|
ENV
GAMFLGFL
601
8
13
20
508
|
|
ENV
GAVFLGFL
601
8
22
34
509
|
|
ENV
FLGFLGAA
604
8
48
75
510
|
|
ENV
FLGAAGST
608
8
55
86
511
|
|
ENV
AAGSTMGA
611
8
58
91
512
|
|
ENV
STMGAASI
614
8
39
61
513
|
|
ENV
TMGAASIT
615
8
39
61
514
|
|
ENV
GAASITLT
617
8
39
61
515
|
|
ENV
AASITLTV
618
8
36
56
516
|
|
ENV
SITLTVQA
620
8
32
50
517
|
|
ENV
LTVQARQL
623
8
38
59
518
|
|
ENV
TVQARQLL
624
8
36
56
519
|
|
ENV
RQLLSGIV
628
8
49
77
520
|
|
ENV
IVQQQNNL
634
8
26
41
521
|
|
ENV
IVQQQSNL
634
8
32
50
522
|
|
ENV
VQQQNNLL
635
8
26
41
523
|
|
ENV
VQQQSNLL
635
8
32
50
524
|
|
ENV
QQNNLLRA
637
8
26
41
525
|
|
ENV
QQSNLLRA
637
8
26
41
526
|
|
ENV
NLLRAIEA
640
8
51
80
527
|
|
ENV
AIEAQQIIL
644
8
49
77
528
|
|
ENV
AQQIILLKL
647
8
13
20
529
|
|
ENV
AQQIILLQL
647
8
35
55
530
|
|
ENV
AQQHMLQL
647
8
10
16
531
|
|
ENV
QQIILLKLT
648
8
13
20
532
|
|
ENV
QQIILLQLT
648
8
34
53
533
|
|
ENV
QQIIMLQLT
648
8
10
16
534
|
|
ENV
LQLTVWGI
652
8
44
69
535
|
|
ENV
TVWGIKQL
655
8
59
92
536
|
|
ENV
KQLQARVL
660
8
41
64
537
|
|
ENV
QLQARVLA
661
8
41
64
538
|
|
ENV
LQARVLAV
662
8
33
52
539
|
|
ENV
VLAVERYL
666
8
34
53
540
|
|
ENV
YLKDQQLL
672
8
31
48
0.0001
541
|
|
ENV
YLRLDQQLL
672
8
18
28
542
|
|
ENV
KLICTTAV
687
8
19
30
543
|
|
ENV
KLICTTNV
687
8
17
27
544
|
|
ENV
KLICTTTV
687
8
12
19
545
|
|
ENV
WMEWEREI
723
8
12
19
546
|
|
ENV
LLALDKWA
755
8
19
30
547
|
|
ENV
LLELDKWA
755
8
21
33
548
|
|
ENV
ALDKWASL
757
8
11
17
549
|
|
ENV
ELDKWASL
757
8
18
28
550
|
|
ENV
SLWNWFDI
763
8
17
27
551
|
|
ENV
ITKWLWYI
770
8
16
25
552
|
|
ENV
ITNWLWYI
770
8
19
30
553
|
|
ENV
YIKIFIMI
776
8
43
67
554
|
|
ENV
FIMIVGGL
780
8
44
69
555
|
|
ENV
IMIVGGLI
781
8
35
56
556
|
|
ENV
IVGGLIGL
783
8
42
66
557
|
|
ENV
IVGGLVGL
783
8
10
16
558
|
|
ENV
GLIGLRII
786
8
15
23
559
|
|
ENV
GLIGLRIV
786
8
32
50
560
|
|
ENV
GLRIIFAV
789
8
18
28
561
|
|
ENV
GLRIVFAV
789
8
29
45
562
|
|
ENV
IIFAVLSI
792
8
15
23
563
|
|
ENV
IVFAVLSI
792
8
20
31
564
|
|
ENV
VLSIVNRV
796
8
38
59
565
|
|
ENV
PLSFQTLL
809
8
10
16
566
|
|
ENV
PLSFQTLT
809
8
13
20
567
|
|
ENV
GLDRPGGT
823
8
01
33
568
|
|
ENV
RLVNGFLA
844
8
13
20
569
|
|
ENV
RLVSGFLA
844
8
20
31
570
|
|
ENV
LVNGFLAL
845
8
14
22
571
|
|
ENV
LVSGFLAL
845
8
19
30
572
|
|
ENV
LALAWDDL
850
8
25
39
573
|
|
ENV
CLFSYIIRL
861
8
42
66
574
|
|
ENV
RLRDLLLI
867
8
13
20
0.0001
575
|
|
ENV
IAARTVEL
874
8
12
19
576
|
|
ENV
AARTVELL
876
8
11
17
577
|
|
ENV
ELLGHSSL
881
8
09
15
578
|
|
ENV
LQYWSQEL
907
8
16
25
579
|
|
ENV
GQELKNSA
911
8
12
19
580
|
|
ENV
SQELKNSA
911
8
12
19
581
|
|
ENV
SAVSLLNA
917
8
11
17
582
|
|
ENV
AVSLLNAT
918
8
11
17
583
|
|
ENV
SLLNATAI
920
8
14
22
584
|
|
ENV
LLNATAIA
921
8
15
23
585
|
|
ENV
DTIAIAVA
923
8
10
16
586
|
|
ENV
NATAIAVA
923
8
14
22
587
|
|
ENV
AIAVAEGT
926
8
32
50
588
|
|
ENV
VAEGTDRI
929
8
19
30
589
|
|
ENV
VAEGTDRV
929
8
16
25
590
|
|
ENV
GTDRVIEV
932
8
11
17
591
|
|
ENV
ILIIIPRRI
947
8
13
20
592
|
|
ENV
PTRIRQGL
951
8
12
19
593
|
|
ENV
RQGLERAL
955
8
35
55
594
|
|
ENV
VTVYYGVPV
47
9
55
86
0.0003
595
|
|
ENV
GVPVWKEAT
52
9
22
34
0.0002
596
|
|
ENV
PVWKEATTT
54
9
22
34
0.0002
597
|
|
ENV
EATTTLFCA
58
9
24
38
0.0002
598
|
|
ENV
TTLFCASDA
61
9
52
81
0.0002
599
|
|
ENV
DAKAYDTEV
70
9
17
27
0.0002
601
|
|
ENV
DTEVIINVWA
75
9
18
28
0.0001
601
|
|
ENV
NVWAIIIACV
80
9
49
77
0.0002
602
|
|
ENV
WATIIACVPT
82
9
56
88
0.0002
603
|
|
ENV
PTDPNPQEI
89
9
25
39
604
|
|
ENV
PTDPNPQEV
89
9
21
33
0.0002
605
|
|
ENV
MVEQMIIEDI
113
9
23
36
0.0002
606
|
|
ENV
QMIIEDIISL
116
9
29
45
0.0023
607
|
|
ENV
IISLWDQSL
121
9
38
59
0.0180
608
|
|
ENV
VISLWDQSL
121
9
10
16
609
|
|
ENV
SLKPCVKLT
128
9
55
86
0.0001
610
|
|
ENV
CVKLTPLCV
132
9
55
86
0.0002
611
|
|
ENV
KLTPLCVTL
134
9
52
81
0.1600
612
|
|
ENV
PLCVILNCT
137
9
22
34
0.0005
613
|
|
ENV
EIKNCSFNI
181
9
13
20
614
|
|
ENV
ALFYRLDVV
202
9
11
17
615
|
|
ENV
VQNNNNSNT
218
9
01
20
616
|
|
ENV
RLINCNTSA
236
9
17
27
617
|
|
ENV
LINCNTSAI
237
9
15
23
618
|
|
ENV
AITQACPKV
244
9
13
20
619
|
|
ENV
VITQACPKV
244
9
15
23
620
|
|
ENV
KVSFEPIPI
252
9
30
47
621
|
|
ENV
CAPAGFAIL
264
9
29
45
0.0001
622
|
|
ENV
STVQCTIIGI
289
9
51
80
0.001
623
|
|
ENV
CTIIGIKPVV
294
9
32
50
624
|
|
ENV
CTHGIRPVV
294
9
26
41
0.0001
625
|
|
ENV
PVVSTQLLL
300
9
60
94
0.0001
626
|
|
ENV
TQLLLNGSL
304
9
57
89
627
|
|
ENV
QLLLNGSLA
305
9
55
86
0.0001
628
|
|
ENV
SLAEEEVVI
311
9
13
20
0.0020
629
|
|
ENV
NAKTIIVQL
329
9
14
22
630
|
|
ENV
ATGDIIGDI
369
9
12
19
631
|
|
ENV
DIIGDIRQA
372
9
12
19
632
|
|
ENV
EIIGDIRQA
372
9
09
15
633
|
|
ENV
GTAGNSSRA
375
9
01
33
634
|
|
ENV
NTSPRSRVA
376
9
01
33
635
|
|
ENV
TAGNSSRAA
376
9
01
33
636
|
|
ENV
DIRQAIICNI
380
9
15
23
637
|
|
ENV
DIRQAIICNV
380
9
10
16
638
|
|
ENV
TLPCRIKQI
484
9
26
41
639
|
|
ENV
QIINMWQEV
491
9
17
27
0.0026
640
|
|
ENV
NMWQEVGKA
494
9
15
23
0.0022
641
|
|
ENV
GQAMYAPPI
501
9
14
22
642
|
|
ENV
GQIRCSSNI
511
9
11
17
643
|
|
ENV
QIRCSSNIT
512
9
11
17
0.0001
644
|
|
ENV
NTETNKTET
537
9
01
17
645
|
|
ENV
NTTGNTTET
537
9
01
17
646
|
|
ENV
VVKIEPLGV
566
9
23
36
647
|
|
ENV
PLGVAPTKA
571
9
23
36
0.0001
648
|
|
ENV
PTKAKRRVV
576
9
22
34
0.0001
649
|
|
ENV
RVVEREKRA
5117
9
32
50
650
|
|
ENV
RVVQREKRA
5117
9
17
27
0.0001
651
|
|
ENV
VVERLKRAV
588
9
25
39
652
|
|
ENV
VVQREKRAV
588
9
16
25
653
|
|
ENV
AVGIGAVFL
595
9
11
17
654
|
|
ENV
ALFLGFLGA
602
9
11
17
0.0950
655
|
|
ENV
AMFLGFLGA
602
9
12
19
656
|
|
ENV
AVFLGFLGA
602
9
19
30
657
|
|
ENV
FLGAAGSTM
608
9
55
86
0.0190
6511
|
|
ENV
GAAGSTMGA
610
9
55
86
0.0009
659
|
|
ENV
AAGSTMGAA
611
9
45
70
0.0001
6611
|
|
ENV
STMGAASIT
614
9
39
61
661
|
|
ENV
TMGAASITL
615
9
39
61
662
|
|
ENV
GAASITLTV
617
9
36
56
663
|
|
ENV
TLTVQARQL
622
9
37
58
664
|
|
ENV
LTVQARQLL
623
9
36
56
665
|
|
ENV
QARQLLSGI
626
9
38
59
666
|
|
ENV
GIVQQQNNL
633
9
26
41
0.0001
667
|
|
ENV
GIVQQQSNL
633
9
32
50
668
|
|
ENV
IVQQQNNLL
634
9
26
41
0.0001
669
|
|
ENV
IVQQQSNLL
634
9
32
50
670
|
|
ENV
QQQNNLLRA
636
9
25
39
671
|
|
ENV
QQQSNLLRA
636
9
26
41
672
|
|
ENV
QQNNLLRAI
637
9
26
41
673
|
|
ENV
QQSNLLRAI
637
9
26
41
674
|
|
ENV
RAIEAQQHL
643
9
45
70
675
|
|
ENV
AIEAQQIILL
644
9
48
75
676
|
|
ENV
EAQQIILLKL
646
9
12
19
677
|
|
ENV
EAQQIILLQL
646
9
35
56
678
|
|
ENV
AQQIILLKLT
647
9
13
20
679
|
|
ENV
AQQIILLQLT
647
9
34
53
680
|
|
ENV
AQQIIMLQLT
647
9
10
16
681
|
|
ENV
QQIILLKLTV
648
9
13
20
682
|
|
ENV
QQIILLQLTV
648
9
34
53
683
|
|
ENV
LLKLTVWGI
651
9
13
20
684
|
|
ENV
LLQLTVWGI
651
9
34
53
0.5100
0.0200
0.2300
0.1500
0.0620
685
|
|
ENV
MLQLTVWGI
651
9
10
16
0.2500
686
|
|
ENV
LTVWGIKQL
654
9
59
92
0.0001
687
|
|
ENV
GIKQLQARV
658
9
40
63
0.00001
688
|
|
ENV
KQLQARVLA
660
9
41
64
689
|
|
ENV
QLQARVLAV
661
9
33
52
0.0085
690
|
|
ENV
RVLAVERYL
665
9
33
52
0.0009
691
|
|
ENV
GIWGCSGKL
680
9
48
75
0.0011
692
|
|
ENV
QQEKNEQDL
747
9
16
25
693
|
|
ENV
QQEKNEQEL
747
9
18
28
694
|
|
ENV
DLLALDKWA
754
9
15
23
695
|
|
ENV
ELLELDKWA
754
9
18
28
0.0002
696
|
|
ENV
LALDKWASL
756
9
11
17
697
|
|
ENV
SLWNWFDIT
763
9
13
20
698
|
|
ENV
DITNWLWYI
769
9
10
16
699
|
|
ENV
WLWYIKIFI
773
9
49
77
0.0360
700
|
|
ENV
YIKIFIMIV
776
9
39
61
0.0001
701
|
|
ENV
FIMIVGGLI
780
9
35
55
702
|
|
ENV
MIVGGLIGL
782
9
36
56
703
|
|
ENV
LIGLRIIFA
787
9
16
25
704
|
|
ENV
LIGLRIVFA
787
9
21
33
705
|
|
ENV
GLRIIFAVL
789
9
17
27
706
|
|
ENV
GLRIVFAVL
789
9
28
44
0.0009
707
|
|
ENV
RIIFAYLSI
791
9
14
22
708
|
|
ENV
RIVFAVLSI
791
9
19
30
0.0002
709
|
|
ENV
IIFAVLSIV
792
9
15
23
710
|
|
ENV
IVFAVLSIV
792
9
18
28
0.0012
711
|
|
ENV
AVLSIVNRV
795
9
31
48
0.0130
712
|
|
ENV
RVRQGYSPL
802
9
55
86
0.0005
713
|
|
ENV
SIRLVNGFL
842
9
11
17
714
|
|
ENV
SIRLVSGFL
842
9
13
20
715
|
|
ENV
RLVNGFLAL
844
9
12
19
716
|
|
ENV
RLVSGFLAL
844
9
19
30
717
|
|
ENV
LVSGFLALA
845
9
16
25
718
|
|
ENV
FLALAWDDL
849
9
25
39
719
|
|
ENV
LAWDDLRSL
852
9
20
31
720
|
|
ENV
LIAARTVEL
873
9
12
19
721
|
|
ENV
IAARTVELL
874
9
11
17
722
|
|
ENV
LLGRRGWEA
882
9
10
16
723
|
|
ENV
GLRLGWEGL
892
9
10
32
724
|
|
ENV
LLQYWSQEL
906
9
16
25
0.0270
725
|
|
ENV
GQELKNSAI
911
9
12
19
726
|
|
ENV
SQELKNSAV
911
9
10
16
727
|
|
ENV
ELKNSAINL
913
9
10
16
728
|
|
ENV
ELKNSAISL
913
9
10
16
729
|
|
ENV
ELKNSAVSL
913
9
12
19
730
|
|
ENV
SAVSLLNAT
917
9
11
17
0.0001
731
|
|
ENV
AVSLLNATA
918
9
11
17
732
|
|
ENV
SLLNATAIA
920
9
14
22
733
|
|
ENV
LLNATAIAV
921
9
15
23
734
|
|
ENV
IAIAVAEGT
925
9
10
16
735
|
|
ENV
TAIAVAEGT
925
9
22
34
736
|
|
ENV
AVAEGTDRI
928
9
16
25
737
|
|
ENV
AVAEGTDRV
928
9
14
22
0.0008
738
|
|
ENV
VAEGTDRII
929
9
18
28
739
|
|
ENV
VAEGTDRVI
929
9
16
25
0.0001
740
|
|
ENV
AILHIPRRI
946
9
12
19
741
|
|
ENV
RIRQGLERA
953
9
34
53
0.0003
742
|
|
ENV
RQGLERALL
955
9
34
53
743
|
|
ENV
ILGLVIICSA
26
10
10
16
744
|
|
ENV
LLGMLMICSA
26
10
10
16
745
|
|
ENV
QLYATVYAGV
34
10
01
50
746
|
|
ENV
KLWVTVYYGV
44
10
11
17
0.0150
747
|
|
ENV
NLWVTVYYGV
44
10
34
54
0.0160
748
|
|
ENV
WVTVYYGVPV
46
10
55
86
0.0009
749
|
|
ENV
GVPVWKEATT
52
10
22
34
0.0001
750
|
|
ENV
PVWKEATTTL
54
10
22
34
0.0001
751
|
|
ENV
KTTLFCASDA
60
10
12
19
752
|
|
ENV
TTTLFCASDA
60
10
24
38
0.0001
753
|
|
ENV
TLFCASDAKA
64
10
46
72
0.0006
754
|
|
ENV
CASDAKAYDT
67
10
19
30
0.0001
755
|
|
ENV
KAYDTEVIINV
72
10
17
27
0.0013
756
|
|
ENV
DTEYIINVWAT
75
10
18
28
0.0001
757
|
|
ENV
EVIINVWATIIA
77
10
35
55
0.0001
758
|
|
ENV
PTDPNPQEVV
89
10
13
20
759
|
|
ENV
NMVEQMIIEDI
112
10
20
31
0.0001
760
|
|
ENV
MVEQMIIEDII
113
10
23
36
0.0001
761
|
|
ENV
EQMIIEDIISL
115
10
22
34
762
|
|
ENV
DIISLWDQSL
120
10
38
59
0.0001
763
|
|
ENV
DVISLWDQSL
120
10
10
16
764
|
|
ENV
DQSLKPCVKL
126
10
47
73
765
|
|
ENV
CVKLTPLCVT
132
10
53
83
0.0001
766
|
|
ENV
STSNSSNSST
159
10
01
50
767
|
|
ENV
VTSTGNSAGT
161
10
01
20
768
|
|
ENV
EIKNCSFNIT
181
10
12
19
769
|
|
ENV
SVQNNNNSNT
217
10
01
33
770
|
|
ENV
RLINCNTSAI
236
10
15
24
771
|
|
ENV
LINCNTSAIT
237
10
14
22
772
|
|
ENV
SAITQACPKV
243
10
13
20
773
|
|
ENV
SVITQACPKV
243
10
15
23
774
|
|
ENV
PIPIHYCAPA
258
10
36
56
0.0002
775
|
|
ENV
PIPIHYCTPA
258
10
18
28
776
|
|
ENV
GTGPCKNVST
281
10
12
19
777
|
|
ENV
CTNVSYVQCT
285
10
13
20
778
|
|
ENV
VQCTIIGIKPV
292
10
32
50
779
|
|
ENV
VQCTIIGIRPV
292
10
25
39
780
|
|
ENV
GIKPVVSTQL
297
10
33
52
781
|
|
ENV
GIRPVVSTQL
297
10
26
41
0.0002
782
|
|
ENV
STQLLLNGSL
303
10
57
89
0.0001
783
|
|
ENV
TQLLLNGSLA
304
10
55
86
784
|
|
ENV
RIGPGQTFYA
357
10
10
16
785
|
|
ENV
GIGPGQTFYA
360
10
01
33
786
|
|
ENV
SIGSGQAFYV
360
10
01
33
787
|
|
ENV
YATUDIIGDI
368
10
11
17
788
|
|
ENV
GTAGNSSRAA
375
10
01
33
789
|
|
ENV
MQNGTNITST
458
10
01
17
790
|
|
ENV
NANITIPCRI
478
10
01
50
791
|
|
ENV
ITLPCRIKQI
483
10
25
39
792
|
|
ENV
TLPCRIKQII
484
10
15
23
793
|
|
ENV
TLPCRIKQIV
484
10
10
16
794
|
|
ENV
KQIINNWQEV
490
10
17
27
795
|
|
ENV
NMWQEVGKAM
494
10
15
23
0.0004
796
|
|
ENV
WQEVGKAMYA
496
10
18
28
797
|
|
ENV
WQRVGQAMYA
496
10
10
16
798
|
|
ENV
GQIRCSSNIT
511
10
11
17
799
|
|
ENV
EIFRPGGGDM
544
10
17
27
0.0001
800
|
|
ENV
ETFRPGGGDM
544
10
21
33
801
|
|
ENV
DMRDNWRSEL
552
10
37
58
0.0001
802
|
|
ENV
ELYKYKVVEI
560
10
13
21
803
|
|
ENV
ELYKYKVVKI
560
10
29
46
804
|
|
ENV
KVVKIEPLGV
565
10
23
36
805
|
|
ENV
VYKIEPLGVA
566
10
23
36
806
|
|
ENV
KIEPLGVAPT
568
10
23
37
807
|
|
ENV
VAPTKAKRRV
574
10
17
27
0.0001
808
|
|
ENV
STRTIIREKRA
586
10
01
50
809
|
|
ENV
RVVEREKRAV
587
10
25
39
810
|
|
ENV
RVVQREKRAV
587
10
16
25
811
|
|
ENV
RAVGIGAVFL
594
10
11
17
812
|
|
ENV
GIGAVFLGFL
598
10
11
18
813
|
|
ENV
MLGAMFLGFL
599
10
04
36
814
|
|
ENV
TIGAMFLGFL
599
10
03
27
815
|
|
ENV
GALFLGFLGA
601
10
11
17
0.0003
816
|
|
ENV
GAMFLGFLGA
601
10
12
19
817
|
|
ENV
GAVFLGFLGA
601
10
19
30
818
|
|
ENV
ALFLGFLGAA
602
10
11
17
0.5000
819
|
|
ENV
AMFLGFLGAA
602
10
12
19
820
|
|
ENV
AVFLGFLGAA
602
10
19
30
821
|
|
ENV
GAAGSTMGAA
610
10
42
66
0.0004
822
|
|
ENV
STMGAASITL
614
10
39
61
823
|
|
ENV
TMGAASITLT
615
10
39
61
824
|
|
ENV
AASITLTVQA
618
10
28
44
825
|
|
ENV
ITLTVQARQL
621
10
27
42
826
|
|
ENV
TLTVQARQLL
622
10
35
55
827
|
|
ENV
VQARQLLSGI
625
10
36
56
828
|
|
ENV
QARQLLSGIV
626
10
38
59
829
|
|
ENV
GIVQQQNNLL
633
10
26
41
0.0002
830
|
|
ENV
GIVQQQSNLL
633
10
32
50
831
|
|
ENV
VQQQNNLLRA
635
10
25
39
832
|
|
ENV
VQQQSNLLRA
635
10
26
41
833
|
|
ENV
QQQNNLLRAI
636
10
25
39
834
|
|
ENV
QQQSNLLRAI
636
10
26
41
835
|
|
ENV
RAIEAQQIILL
643
10
44
69
836
|
|
ENV
EAQQIILLKLT
646
10
12
19
837
|
|
ENV
EAQQIILLQLT
646
10
34
54
838
|
|
ENV
AQQIILLKLTV
647
10
13
20
839
|
|
ENV
AQQIILLQLTV
647
10
34
53
840
|
|
ENV
IILLKLTVWGI
650
10
13
20
841
|
|
ENV
IILLQLTVWGI
650
10
34
53
842
|
|
ENV
KLTVWGIKQL
653
10
13
20
843
|
|
ENV
QLTVWGIKQL
653
10
44
69
0.0015
844
|
|
ENV
TVWGIKQLQA
655
10
49
77
0.0150
845
|
|
ENV
GIKQLQARVL
658
10
40
63
0.0002
846
|
|
ENV
KQLQARVLAV
660
10
33
52
847
|
|
ENV
VLKDQQLLGI
672
10
27
42
848
|
|
ENV
YLRDQQLLGI
672
10
18
28
849
|
|
ENV
GIWGCSGKLI
680
10
48
75
0.0004
850
|
|
ENV
MTWMEWERLEI
721
10
12
19
851
|
|
ENV
NQQEKNEQDL
746
10
13
20
852
|
|
ENV
NQQEKNEQEL
746
10
15
23
853
|
|
ENV
QQEKNEQDLL
747
10
16
25
854
|
|
ENV
QQEKNEQELL
747
10
18
28
855
|
|
ENV
LLALDKWASL
755
10
11
17
856
|
|
ENV
LLELDKWASL
755
10
18
28
0.0024
857
|
|
ENV
WASLWNWFDI
761
10
17
27
858
|
|
ENV
ITKWLWYIKI
770
10
15
23
859
|
|
ENV
ITNWLWYIKI
770
10
14
22
0.0002
860
|
|
ENV
WLWYIKIFIM
773
10
43
67
0.0001
861
|
|
ENV
KIFIMIVGGL
778
10
38
59
0.0003
862
|
|
ENV
IMIVGGLIGL
781
10
34
54
863
|
|
ENV
IVGGLIGLRI
783
10
42
66
864
|
|
ENV
GLIGLRIIFA
786
10
15
23
865
|
|
ENV
GLIGLRIVFA
786
10
21
33
866
|
|
ENV
LIGLRIIFAV
787
10
16
25
867
|
|
ENV
LIGLRIVFAV
787
10
21
33
868
|
|
ENV
RIIFAVLSIV
791
10
14
22
869
|
|
ENV
RIVFAVLSIV
791
10
17
27
0.0007
870
|
|
ENV
FAVLSIVNRV
794
10
31
48
0.0002
871
|
|
ENV
SIRLVSGFLA
842
10
12
19
872
|
|
ENV
RLVSGFLALA
844
10
16
25
873
|
|
ENV
ALAWDDLRSL
851
10
19
30
874
|
|
ENV
NLCLFSYIIRL
859
10
11
17
875
|
|
ENV
SLCLFSYHRL
8S9
10
31
48
876
|
|
ENV
LIAARTVELL
873
10
11
17
877
|
|
ENV
ELLGRRGWEA
881
10
10
16
878
|
|
ENV
LLGRRGWEAL
882
10
09
15
879
|
|
ENV
RLGWEGLKYL
894
10
09
29
880
|
|
ENV
NLLQYWSQEL
905
10
16
25
0.0059
881
|
|
ENV
ELKNSAVSLL
913
10
10
16
882
|
|
ENV
SAVSLLNATA
917
10
11
17
883
|
|
ENV
AVSLLNATAI
918
10
11
17
884
|
|
ENV
SLLNATAIAV
920
10
14
22
0.0650
0.0074
0.0390
0.0600
0.0390
885
|
|
ENV
LLNATAIAVA
921
10
14
22
0.0740
886
|
|
ENV
ATAIAVAEGT
924
10
14
22
887
|
|
ENV
IAVAEGTDRI
927
10
16
25
888
|
|
ENV
IAVAEGTDRV
927
10
14
22
0.0001
889
|
|
ENV
AVAEGTDRII
928
10
15
23
890
|
|
ENV
AVAEGTDRVI
928
10
14
22
0.0004
891
|
|
ENV
RAILIIIRRI
945
10
12
19
892
|
|
ENV
IIIPRRIRQGL
949
10
13
21
893
|
|
ENV
NIPRRIRQGL
949
10
11
17
894
|
|
ENV
RIRQGLERAL
953
10
34
53
0.0001
895
|
|
ENV
LILGLVIICSA
21
11
09
15
896
|
|
ENV
KQLYATVYSGV
34
11
01
50
897
|
|
ENV
GVPVWKEATTT
52
11
22
34
898
|
|
ENV
ATTLFCASDA
59
11
23
36
899
|
|
ENV
TTLFCASDAKA
61
11
44
69
900
|
|
ENV
NVWATIIACVPT
80
11
48
75
901
|
|
ENV
CVPTDPNPQEI
87
11
25
39
902
|
|
ENV
CVPTDPNPQEV
87
11
21
33
903
|
|
ENV
PTDPNPQEVVL
89
11
12
19
904
|
|
ENV
NMWKNNMVEQM
107
11
30
47
905
|
|
ENV
NMVEQMHEDII
112
11
20
31
906
|
|
ENV
SLWDQSLKPCV
123
11
47
75
907
|
|
ENV
DQSLKPCVKLT
126
11
47
73
908
|
|
ENV
SLKPCVKLTPL
128
11
54
84
909
|
|
ENV
CVKLTPLCVTL
132
11
52
81
910
|
|
ENV
LTPLCVTLNCT
135
11
22
34
911
|
|
ENV
EIKNCSFNITT
181
11
11
17
912
|
|
ENV
RLINCNTSAIT
236
11
14
22
913
|
|
ENV
QACPKVSFEPI
248
11
30
47
914
|
|
ENV
PIIIYCAPAGFA
260
11
27
42
915
|
|
ENV
PIIIYCTPAGFA
260
11
10
16
916
|
|
ENV
GTGPCKNVSTV
281
11
12
19
917
|
|
ENV
NVSTVQCTIIGI
287
11
51
80
918
|
|
ENV
TVQCTIIGIKPV
290
11
28
44
919
|
|
ENV
TVQCTIIGIRPV
290
11
22
34
920
|
|
ENV
VQCTHGIKPVV
292
11
31
48
921
|
|
ENV
VQCTHGIRPVV
292
11
25
39
922
|
|
ENV
CTHGIKPVVST
294
11
32
50
923
|
|
ENV
CTHGIRPVVST
294
11
26
41
924
|
|
ENV
GIKPVVSTQLL
297
11
33
52
925
|
|
ENV
GIRPVVSTQLL
297
11
26
41
926
|
|
ENV
STQLLLNGSLA
303
11
55
86
927
|
|
ENV
LLNGSLAEEEV
307
11
16
25
928
|
|
ENV
EINCTRPNNNT
342
11
10
16
929
|
|
ENV
RIGPGQTFYAT
357
11
10
16
930
|
|
ENV
GIGPGQTFYAT
360
11
01
33
931
|
|
ENV
SIGSGQAFYVT
360
11
01
33
932
|
|
ENV
EMHTNYTSNDT
458
11
01
17
933
|
|
ENV
NITLPCRIKQI
482
11
11
17
934
|
|
ENV
TITLPCRIKQI
482
11
13
20
935
|
|
ENV
ITLPCRIKQII
483
11
15
23
936
|
|
ENV
IINMWQEVGKA
492
11
12
19
937
|
|
ENV
EVGKAMYAPPI
498
11
18
28
938
|
|
ENV
RVGQAMYAPPI
498
11
10
16
939
|
|
ENV
QIRCSSNITGL
512
11
11
17
940
|
|
ENV
KVVKIEPLGVA
565
11
23
36
941
|
|
ENV
GVAPTKAKRRV
573
11
17
27
942
|
|
ENV
VAPTKAKRRVV
574
11
17
27
943
|
|
ENV
NIIITPIIREKRA
586
11
01
50
944
|
|
ENV
STRTIIREKRAV
586
11
01
50
945
|
|
ENV
VVEREKRAVGI
588
11
11
17
946
|
|
ENV
GALFLGFLGAA
601
11
11
17
947
|
|
ENV
GAMFLGFLGAA
601
11
12
19
948
|
|
ENV
GAVFLGFLGAA
601
11
19
30
949
|
|
ENV
FLGFLGAAGST
604
11
48
75
950
|
|
ENV
FLGAAGSTMGA
608
11
55
86
951
|
|
ENV
AAGSTMGAASI
611
11
34
53
952
|
|
ENV
STMGAASITLT
614
11
39
61
953
|
|
ENV
TMGAASITLTV
615
11
36
56
954
|
|
ENV
GAASITLTVQA
617
11
28
44
955
|
|
ENV
SITLTVQARQL
620
11
27
42
956
|
|
ENV
ITLTVQARQLL
621
11
27
42
957
|
|
ENV
TVQARQLLSGI
624
11
36
56
958
|
|
ENV
VQARQLLSGIV
625
11
36
56
959
|
|
ENV
IVQQQNNLLRA
634
11
25
39
960
|
|
ENV
IVQQQSNLLRA
634
11
26
41
961
|
|
ENV
VQQQNNLLRAI
635
11
25
39
962
|
|
ENV
VQQQSNLLRAI
635
11
26
41
963
|
|
ENV
QQNNLLRAIEA
637
11
26
41
964
|
|
ENV
QQSNLLRAIEA
637
11
23
36
965
|
|
ENV
LLRAIEAQQIIL
641
11
45
70
966
|
|
ENV
AIEAQQIILLKL
644
11
12
19
967
|
|
ENV
AIEAQQIILLQL
644
11
35
55
968
|
|
ENV
EAQQHLLKLTV
646
11
12
19
969
|
|
ENV
EAQQIILLQLTV
646
11
34
54
970
|
|
ENV
LQLTVWGIKQL
652
11
44
69
971
|
|
ENV
LTVWGIKQLQA
654
11
49
77
972
|
|
ENV
GIKQLQARVLA
658
11
40
63
973
|
|
ENV
QARVLAVERYL
663
11
33
52
974
|
|
ENV
AVERYLKDQQL
668
11
23
36
975
|
|
ENV
AVERYLRDQQL
668
11
11
17
976
|
|
ENV
LLGIWGCSGKL
678
11
46
72
977
|
|
ENV
NMTWMEWEREI
720
11
12
19
978
|
|
ENV
NQQEKNEQDLL
746
11
13
20
979
|
|
ENV
NQQEKNEQELL
746
11
15
23
980
|
|
ENV
QQEKNEQDLLA
747
11
16
25
981
|
|
ENV
EQDLLALDKWA
752
11
12
19
982
|
|
ENV
EQELLELDKWA
752
11
11
17
983
|
|
ENV
ELLELDKWASL
754
11
15
23
984
|
|
ENV
WASLWNWFDIT
761
11
13
20
985
|
|
ENV
WLWYIKIFIMI
773
11
43
67
986
|
|
ENV
KIFIMIVGGLI
778
11
31
48
987
|
|
ENV
FIMIVGGLIGL
780
11
34
53
988
|
|
ENV
MIVGGLIGLRI
782
11
36
56
989
|
|
ENV
IVGGLIGLRII
783
11
12
19
990
|
|
ENV
IVGGLIGLRIV
783
11
30
47
991
|
|
ENV
GLIGLRIIFAV
786
11
15
23
992
|
|
ENV
GLIGLRIVFAV
786
11
21
33
993
|
|
ENV
LIGLRIIFAVL
787
11
15
23
994
|
|
ENV
LIGLRIVFAVL
787
11
20
31
995
|
|
ENV
GLRIIFAVLSI
789
11
14
22
996
|
|
ENV
GLRIVFAVLSI
789
11
19
30
997
|
|
ENV
RQGYSPLSFQT
804
11
45
70
998
|
|
ENV
SIRLVSGFLAL
842
11
11
17
999
|
|
ENV
LALAWDDLRSL
850
11
19
30
1000
|
|
ENV
LAWDDLRSLCL
852
11
20
31
1001
|
|
ENV
CLFSYIIRLRDL
861
11
20
31
1002
|
|
ENV
ELLGRRGWEAL
881
11
09
15
1003
|
|
ENV
SQELKNSAVSL
911
11
10
16
1004
|
|
ENV
SAVSLLNATAI
917
11
11
17
1005
|
|
ENV
AVSLLNATAIA
918
11
11
17
1006
|
|
ENV
SLLNATAIAVA
920
11
13
20
0.2700
1007
|
|
ENV
NATAIAVAEGT
923
11
13
20
1008
|
|
ENV
AIAVAEGTDRI
926
11
16
25
1009
|
|
ENV
AIAVAEGTDRV
926
11
14
22
1010
|
|
ENV
IAVAEGTDRII
927
11
15
23
1011
|
|
ENV
IAVAEGTDRVI
927
11
14
22
1012
|
|
ENV
PTRIRQGLERA
951
11
11
17
1013
|
|
ENV
RIRQGLERALL
953
11
33
52
1014
|
|
GAG
SVLSGGEL
6
8
11
17
1015
|
|
GAG
SVLSGGKL
6
8
28
44
1016
|
|
GAG
KLDAWEKI
12
8
18
28
1017
|
|
GAG
KLDKWEKI
12
8
10
16
1018
|
|
GAG
DAWEKIRL
14
8
17
27
1019
|
|
GAG
KLKHIVWA
31
8
13
20
1020
|
|
GAG
RLKIILVWA
31
8
17
27
1021
|
|
GAG
IVWASREL
35
8
21
33
1022
|
|
GAG
LVWASREL
35
8
36
56
1023
|
|
GAG
FALNPGLL
46
8
22
34
1024
|
|
GAG
FAVNPGLL
46
8
16
25
1025
|
|
GAG
QLQPALQT
65
8
17
27
1026
|
|
GAG
QLQPSLQT
65
8
15
23
1027
|
|
GAG
LQTGSEEL
70
8
17
27
1028
|
|
GAG
GTEELRSL
73
8
12
19
1029
|
|
GAG
ELRSLYNT
76
8
17
27
1030
|
|
GAG
SLFNTVAT
79
8
16
25
1031
|
|
GAG
SLYNTVAT
79
8
22
34
1032
|
|
GAG
TYATLYCV
83
8
41
64
1033
|
|
GAG
DVKDTKEA
95
8
11
17
1034
|
|
GAG
EVKDTKEA
95
8
22
34
1035
|
|
GAG
AQQAAADT
119
8
10
16
1036
|
|
GAG
AQQAAAAT
132
8
01
33
1037
|
|
GAG
KVSQNYPI
148
8
15
27
1038
|
|
GAG
QVSQNYPI
148
8
27
48
1039
|
|
GAG
VQNAQGQM
156
8
21
33
1040
|
|
GAG
VQNLQGQM
156
8
29
45
1041
|
|
GAG
GQMVIIQAI
161
8
28
44
1042
|
|
GAG
IIQAISPRT
165
8
29
45
1043
|
|
GAG
IIQALSPRT
165
8
11
17
1044
|
|
GAG
QAISPRTL
166
8
29
45
1045
|
|
GAG
QALSPRTL
166
8
11
17
1046
|
|
GAG
TLNAWVKV
172
8
61
95
1047
|
|
GAG
KAFSPEVI
183
8
50
78
1048
|
|
GAG
EVIPMFSA
188
8
46
72
1049
|
|
GAG
EVIPMFTA
188
8
14
22
1050
|
|
GAG
VIPMFSAL
189
8
46
72
1051
|
|
GAG
VIPMFTAL
189
8
14
22
1052
|
|
GAG
FTALSEGA
193
8
15
23
1053
|
|
GAG
SALSEGAT
194
8
44
69
1054
|
|
GAG
TALSEGAT
194
8
15
23
1055
|
|
GAG
ATPQDLNM
200
8
12
19
1056
|
|
GAG
ATPQDLNT
200
8
42
66
1057
|
|
GAG
PQDLNMML
202
8
12
19
1058
|
|
GAG
PQDLNTML
202
8
43
67
1059
|
|
GAG
DLNMMLNI
204
8
12
19
1060
|
|
GAG
DLNTMLNT
204
8
44
69
1061
|
|
GAG
NIVGGIIQA
210
8
12
19
1062
|
|
GAG
NTVGGIIQA
210
8
47
73
1063
|
|
GAG
IVGGIIQAA
211
8
12
19
1064
|
|
GAG
TVGGIIQAA
211
8
47
73
1065
|
|
GAG
HQAAMQML
215
8
61
95
1066
|
|
GAG
AMQMLKDT
218
8
33
52
1067
|
|
GAG
AMQMLKET
218
8
26
41
1068
|
|
GAG
MQMLKDTI
219
8
33
52
1069
|
|
GAG
MQMLKETI
219
8
26
41
1070
|
|
GAG
DTINEEAA
224
8
33
52
1071
|
|
GAG
ETINEEAA
224
8
22
34
1072
|
|
GAG
EAAEWDRL
229
8
39
61
1073
|
|
GAG
EAAEWDRV
229
8
15
23
1074
|
|
GAG
PVHAGPIA
238
8
19
30
1075
|
|
GAG
DIAGTTST
256
8
55
86
1076
|
|
GAG
IAGTTSTL
257
8
48
75
1077
|
|
GAG
STLQEQIA
262
8
12
19
1078
|
|
GAG
LQEQIAWM
264
8
14
22
1079
|
|
GAG
LQEQIGWM
264
8
29
45
1080
|
|
GAG
WMTNNPPI
270
8
20
31
1081
|
|
GAG
WMTSNPPI
270
8
16
25
1082
|
|
GAG
DIYKRWII
284
8
17
27
1083
|
|
GAG
EIYKRWII
284
8
39
61
1084
|
|
GAG
IILGLNKI
290
8
57
89
1085
|
|
GAG
ILGLNKIV
291
8
58
91
1086
|
|
GAG
GLNKIVRM
293
8
60
94
1087
|
|
GAG
IVRMYSPT
297
8
15
23
1088
|
|
GAG
IVRMYSPV
297
8
42
66
1089
|
|
GAG
RMYSPTSI
299
8
14
22
1090
|
|
GAG
RMYSPVSI
299
8
40
63
1091
|
|
GAG
YVDRFFKT
320
8
28
44
1092
|
|
GAG
YVDRFYKT
320
8
28
44
1093
|
|
GAG
KTLRAEQA
326
8
54
84
1094
|
|
GAG
TLRAEQAT
327
8
35
55
1095
|
|
GAG
SQEVKNWM
334
8
11
17
1096
|
|
GAG
TQDVKNWM
334
8
15
23
1097
|
|
GAG
TQEVKNWM
334
8
18
28
1098
|
|
GAG
WMTDTLLV
340
8
22
34
1099
|
|
GAG
WMTETLLV
340
8
37
58
1100
|
|
GAG
DTLLVQNA
343
8
22
34
1101
|
|
GAG
ETLLVQNA
343
8
37
58
1102
|
|
GAG
NANPDCKT
349
8
45
70
1103
|
|
GAG
ILKALGPA
357
8
16
25
1104
|
|
GAG
KALGPAAT
359
8
16
25
1105
|
|
GAG
ALGPAATL
360
8
16
25
1106
|
|
GAG
ALGPGATL
360
8
18
28
1107
|
|
GAG
PAATLEEM
363
8
16
25
1108
|
|
GAG
AATLEEMM
364
8
16
25
1109
|
|
GAG
GASLEEMM
364
8
10
16
1110
|
|
GAG
GATLEEMM
364
8
29
45
1111
|
|
GAG
ATLEEMMT
365
8
46
72
1112
|
|
GAG
SLEEMMTA
366
8
11
17
1113
|
|
GAG
TLEEMMTA
366
8
46
72
1114
|
|
GAG
MMTACQGV
370
8
60
94
1115
|
|
GAG
KARVLAEA
383
8
57
89
1116
|
|
GAG
LAEAMSQA
387
8
17
27
1117
|
|
GAG
LAEAMSQV
387
8
36
57
1118
|
|
GAG
SQVTNSAT
394
8
10
16
1119
|
|
GAG
IIIAKNCRA
433
8
18
28
1120
|
|
GAG
HIARNCRA
433
8
13
20
1121
|
|
GAG
HLARNCRA
433
8
21
33
1122
|
|
GAG
QANFLGKI
466
8
57
89
1123
|
|
GAG
GTRPGNYV
480
8
02
100
1124
|
|
GAG
LQNRPEPT
487
8
10
16
1125
|
|
GAG
LQSRPEPT
487
8
28
44
1126
|
|
GAG
ELYPLASL
543
8
14
22
1127
|
|
GAG
ELYPLTSL
543
8
11
17
1128
|
|
GAG
PLASLKSL
548
8
15
23
1129
|
|
GAG
PLTSLKSL
548
8
12
19
1130
|
|
GAG
PLTSLRSL
548
8
12
19
1131
|
|
GAG
SLFGNDPL
554
8
12
19
1132
|
|
GAG
SLFGSDPL
554
8
11
17
1133
|
|
GAG
VLSGGKLDA
7
9
15
23
1134
|
|
GAG
IIIVWASREL
34
9
21
33
1135
|
|
GAG
IILVWASREL
34
9
36
56
1136
|
|
GAG
ALNPGLLET
47
9
19
30
1137
|
|
GAG
AVNPGLLET
47
9
14
22
1138
|
|
GAG
ETSEGCRQI
54
9
16
25
1139
|
|
GAG
ILGQLQPSL
62
9
11
17
1140
|
|
GAG
GQLQPSLQT
64
9
11
17
1141
|
|
GAG
LQPALQTGT
66
9
14
22
1142
|
|
GAG
SLQTGSEEL
69
9
14
22
1143
|
|
GAG
ELRSLYNTV
76
9
15
23
1144
|
|
GAG
SLFNTVATL
79
9
16
25
0.0037
1145
|
|
GAG
SLYNTVATL
79
9
22
34
0.0053
0.0012
0.2000
0.0001
0.0004
1146
|
|
GAG
NTVATLYCV
82
9
41
64
1147
|
|
GAG
TLYCVIIQKI
86
9
12
19
1148
|
|
GAG
TLYCVIIQRI
86
9
15
23
1149
|
|
GAG
IIQRIEVKDT
91
9
10
16
1150
|
|
GAG
DVKDTKEAL
95
9
11
17
1151
|
|
GAG
EVKDTKEAL
95
9
20
31
1152
|
|
GAG
DTKEALDKI
98
9
32
50
1153
|
|
GAG
DTKEALEKI
98
9
10
16
1154
|
|
GAG
EQNKSKKKA
109
9
17
27
1155
|
|
GAG
KAQQAAADT
118
9
10
16
1156
|
|
GAG
SQVSQNYPI
146
9
22
44
1157
|
|
GAG
KVSQNYPIV
148
9
15
27
1158
|
|
GAG
QVSQNYPIV
148
9
27
48
0.0001
1159
|
|
GAG
IVQNAQGQM
155
9
21
33
1160
|
|
GAG
IVQNLQGQM
155
9
29
45
1161
|
|
GAG
VQNAQGQMV
156
9
14
22
1162
|
|
GAG
VQNLQGQMV
156
9
29
45
1163
|
|
GAG
AQGQMVIIQA
159
9
12
19
1164
|
|
GAG
LQGQMVIIQA
159
9
21
33
1165
|
|
GAG
IIQAISPRTL
165
9
29
45
1166
|
|
GAG
IIQALSPRTL
165
9
11
17
1167
|
|
GAG
AISPRTLNA
167
9
29
45
1168
|
|
GAG
ALSPRTLNA
167
9
10
16
1169
|
|
GAG
RTLNAWVKV
171
9
61
95
0.0012
1170
|
|
GAG
TLNAWVKVI
172
9
30
47
0.0032
1171
|
|
GAG
TLNAWVKVV
172
9
31
48
0.0005
1172
|
|
GAG
WVKVIEEKA
176
9
25
39
1173
|
|
GAG
WVKVVEEKA
176
9
28
44
1174
|
|
GAG
EVIPMFSAL
188
9
46
72
0.0001
1175
|
|
GAG
EVIPMFTAL
188
9
14
22
1176
|
|
GAG
FTALSEGAT
193
9
15
23
1177
|
|
GAG
GATPQDLNM
199
9
12
19
1178
|
|
GAG
GATPQDLNT
199
9
42
66
1179
|
|
GAG
ATPQDLNMM
200
9
12
19
1180
|
|
GAG
ATPQDLNTM
200
9
42
66
1181
|
|
GAG
DLNMMLNIV
204
9
12
19
1182
|
|
GAG
DLNTMLNTV
204
9
42
66
0.0001
1183
|
|
GAG
NIVGGHQAA
210
9
12
19
1184
|
|
GAG
NTVGGIIQAA
210
9
47
73
1185
|
|
GAG
IVGGHQAAM
211
9
12
19
1186
|
|
GAG
TVGGIIQAAM
211
9
47
73
1187
|
|
GAG
AAMQMLKDT
217
9
33
52
1188
|
|
GAG
AAMQMLKET
217
9
26
41
1189
|
|
GAG
AMQMLKDTI
218
9
33
52
1190
|
|
GAG
AMQMLKETI
218
9
26
41
1191
|
|
GAG
DIAGTTSTL
256
9
48
75
0.0001
1192
|
|
GAG
TTSTLQEQI
260
9
45
71
1193
|
|
GAG
TLQEQIAWM
263
9
12
19
1194
|
|
GAG
TLQEQIGWM
263
9
27
42
1195
|
|
GAG
LQEQIAWMT
264
9
14
22
1196
|
|
GAG
LQEQIGWMT
264
9
29
45
1197
|
|
GAG
MTNNPPIPV
271
9
20
31
0.0300
0.0006
0.3000
0.0023
3.3000
1198
|
|
GAG
MTSNPPIPV
271
9
16
25
1199
|
|
GAG
DIYKRWIIL
284
9
17
27
1200
|
|
GAG
EIYKRWIIL
284
9
37
58
0.0001
1201
|
|
GAG
WIILGLNKI
289
9
57
89
0.0091
1202
|
|
GAG
IILGLNKIV
290
9
57
89
0.0003
1203
|
|
GAG
KIVRMYSPT
296
9
15
23
1204
|
|
GAG
KIVRMYSPV
296
9
41
64
1205
|
|
GAG
RMYSPTSIL
299
9
14
22
0.0007
1206
|
|
GAG
RMYSPVSIL
299
9
40
63
1207
|
|
GAG
YVDRFFKTL
320
9
27
42
1208
|
|
GAG
YVDRFYKTL
320
9
28
44
0.0010
1209
|
|
GAG
KTLRAEQAT
326
9
34
53
1210
|
|
GAG
RAEQASQEV
329
9
12
19
1211
|
|
GAG
RAEQATQDV
329
9
15
23
1212
|
|
GAG
RAEQATQEV
329
9
27
42
1213
|
|
GAG
ATQDVKNWM
333
9
15
23
1214
|
|
GAG
ATQEVKNWM
333
9
18
28
1215
|
|
GAG
SQEVKNWMT
334
9
11
17
1216
|
|
GAG
TQDVKNWMT
334
9
15
23
1217
|
|
GAG
TQEVKNWMT
334
9
18
28
1218
|
|
GAG
DVKNWMTDT
336
9
12
19
1219
|
|
GAG
DVKNWMTET
336
9
12
19
1220
|
|
GAG
EVKNWMTET
336
9
25
39
1221
|
|
GAG
NANPDCKSI
349
9
11
17
1222
|
|
GAG
NANPDCKTI
349
9
45
70
1223
|
|
GAG
TILKALGPA
356
9
16
25
1224
|
|
GAG
ILKALGPAA
357
9
16
25
0.0001
1225
|
|
GAG
ILRALGPGA
357
9
18
28
1226
|
|
GAG
KALGPAATL
359
9
16
25
0.0001
1227
|
|
GAG
PAATLEEMM
363
9
16
25
1228
|
|
GAG
AATLEEMMT
364
9
16
25
1229
|
|
GAG
GASLEEMMT
364
9
10
16
1230
|
|
GAG
GATLEEMMT
364
9
28
44
1231
|
|
GAG
ATLEEMMTA
365
9
46
72
1232
|
|
GAG
EMMTACQGV
369
9
59
92
0.0006
1233
|
|
GAG
GVGGPGIIKA
376
9
37
58
1234
|
|
GAG
GVGGPSHKA
376
9
23
36
1235
|
|
GAG
KARVLAEAM
383
9
57
89
1236
|
|
GAG
VLAEAMSQA
386
9
16
25
1237
|
|
GAG
VLAEAMSQV
386
9
33
52
0.1100
1238
|
|
GAG
LAEAMSQVT
387
9
23
37
1239
|
|
GAG
AMSQVTNSA
390
9
11
17
1240
|
|
GAG
CTERQANFL
459
9
55
87
1241
|
|
GAG
RQANFLGKI
465
9
56
88
1242
|
|
GAG
FLQNRPEPT
486
9
10
16
1243
|
|
GAG
FLQSRPEPT
486
9
28
44
0.0110
0.0004
0.3100
0.0002
0.0130
1244
|
|
GAG
LQNRPEPTA
487
9
10
16
1245
|
|
GAG
LQSRPEPTA
487
9
28
44
1246
|
|
GAG
PAEPIAPPA
492
9
01
50
1247
|
|
GAG
KQEPIDKEL
531
9
12
19
1248
|
|
GAG
PIDKELYPL
534
9
12
19
1249
|
|
GAG
KQEPIDKEL
535
9
01
25
1250
|
|
GAG
KQETIDKDL
535
9
01
25
1251
|
|
GAG
PIDKELYPL
538
9
01
25
1252
|
|
GAG
TIDKDLYPL
538
9
01
25
1253
|
|
GAG
RASVLSGGEL
4
10
11
17
1254
|
|
GAG
RASVLSGGKL
4
10
28
44
1255
|
|
GAG
SVLSGGKLDA
6
10
15
23
1256
|
|
GAG
KLDAWEKIRL
12
10
16
25
1257
|
|
GAG
KLDKWEKIRL
12
10
10
16
1258
|
|
GAG
WASRELERFA
37
10
44
69
1259
|
|
GAG
FALNPGLLET
46
10
18
28
1260
|
|
GAG
FAVNPGLLET
46
10
14
22
1261
|
|
GAG
ETSEGCRQIL
54
10
14
22
1262
|
|
GAG
QILGQLQPSL
61
10
11
17
1263
|
|
GAG
QLQPALQIGT
65
10
14
22
1264
|
|
GAG
QTGSEELRSL
71
10
12
19
1265
|
|
GAG
ELRSLYNTVA
76
10
15
23
1266
|
|
GAG
ATLYCVIIQKI
85
10
12
19
1267
|
|
GAG
ATLYCVIIQRI
85
10
15
23
1268
|
|
GAG
RIEVKDTKEA
93
10
13
20
1269
|
|
GAG
GAAAATDSNI
123
10
01
50
1270
|
|
GAG
AAGTGNSSQV
130
10
01
50
1271
|
|
GAG
SQVSQNYPIV
146
10
22
44
1272
|
|
GAG
SQNYPIVQNA
150
10
22
34
1273
|
|
GAG
SQNYPIVQNL
150
10
30
47
1274
|
|
GAG
PIVQNAQGQM
154
10
21
33
1275
|
|
GAG
PIVQNLQGQM
154
10
29
45
1276
|
|
GAG
IVQNAQGQMV
155
10
14
22
1277
|
|
GAG
IVQNLQGQMV
155
10
29
45
1278
|
|
GAG
NAQGQMVIIQA
158
10
12
19
1279
|
|
GAG
NLQGQMVIIQA
158
10
21
33
1280
|
|
GAG
LQGQMVIIQAI
159
10
15
23
1281
|
|
GAG
MVIIQAISPRT
163
10
27
42
1282
|
|
GAG
QAISPRTLNA
166
10
29
45
1283
|
|
GAG
QALSPRTLNA
166
10
10
16
1284
|
|
GAG
RTLNAWVKVI
171
10
31
47
1285
|
|
GAG
RTLNAWVKVV
171
10
31
48
0.0003
1286
|
|
GAG
KAFSPEVIPM
183
10
50
78
1287
|
|
GAG
PMFSALSEGA
191
10
45
70
1288
|
|
GAG
PMFTALSEGA
191
10
15
23
1289
|
|
GAG
GATPQDLNMM
199
10
12
19
1290
|
|
GAG
GATPQDLNTM
199
10
42
66
1291
|
|
GAG
ATPQDLNMML
200
10
12
19
1292
|
|
GAG
ATPQDLNTML
200
10
42
66
1293
|
|
GAG
PQDLNMMLNI
202
10
11
17
1294
|
|
GAG
PQDLNTMLNT
202
10
43
67
1295
|
|
GAG
MLNIVGGIIQA
208
10
12
19
1296
|
|
GAG
MLNTVGGIIQA
208
10
47
73
0.0022
1297
|
|
GAG
NIVGGHQAAM
210
10
12
19
1298
|
|
GAG
NTVGGIIQAAM
210
10
47
73
1299
|
|
GAG
QAAMQMLKDT
216
10
33
52
1300
|
|
GAG
QAAMQMLKET
216
10
26
41
1301
|
|
GAG
AAMQMLKDTI
217
10
33
52
1302
|
|
GAG
AAMQMLKETI
217
10
26
41
1303
|
|
GAG
MLKDTINEEA
221
10
32
50
1304
|
|
GAG
MLKETINEEA
221
10
22
34
1305
|
|
GAG
AAEWDKLIIPV
230
10
34
53
1306
|
|
GAG
AAEWDRVIIPV
230
10
14
22
1307
|
|
GAG
RLHPVHAGPI
235
10
22
34
1308
|
|
GAG
RVIIPVHAGPI
235
10
14
22
1309
|
|
GAG
HAGPIAPGQM
240
10
18
28
1310
|
|
GAG
HAGPIPPGQM
240
10
17
27
1311
|
|
GAG
QMREPRGSDI
248
10
44
69
1312
|
|
GAG
GTTSTLQEQI
259
10
45
70
1313
|
|
GAG
TTSTLQEQIA
260
10
11
17
1314
|
|
GAG
STLQEQIAWM
262
10
12
19
1315
|
|
GAG
STLQEQIGWM
262
10
27
42
1316
|
|
GAG
TLQEQIAWMT
263
10
12
19
1317
|
|
GAG
TLQEQIGWMT
263
10
27
42
1318
|
|
GAG
WMTNNPPIPV
270
10
20
31
0.0510
0.0014
0.5900
0.0002
0.0180
1319
|
|
GAG
WMTSNPPIPV
270
10
16
25
1320
|
|
GAG
GANSIPVGDI
276
10
01
50
1321
|
|
GAG
PVGDIYKRWI
281
10
17
27
1322
|
|
GAG
PVGEIYKRWI
281
10
40
63
1323
|
|
GAG
WIILGLNKIV
289
10
57
89
0.0009
1324
|
|
GAG
ILGLNKIVRM
291
10
57
89
0.0010
1325
|
|
GAG
IVRMYSPTSI
297
10
14
22
1326
|
|
GAG
IVRMYSPVSI
297
10
40
63
1327
|
|
GAG
QASQEVKNWM
332
10
11
17
1328
|
|
GAG
QATQDVKNWM
332
10
15
23
1329
|
|
GAG
QATQEVKNWM
332
10
18
28
1330
|
|
GAG
ATQDVKNWMT
333
10
15
23
1331
|
|
GAG
ATQEVKNWMT
333
10
18
28
1332
|
|
GAG
DVKNWMTDTL
336
10
12
19
1333
|
|
GAG
DVKNWMTETL
336
10
11
17
1334
|
|
GAG
EVKNWMTETL
336
10
25
39
1335
|
|
GAG
MTDTLLVQNA
341
10
22
34
1336
|
|
GAG
MTETLLVQNA
341
10
36
56
1337
|
|
GAG
VQNANPDCKT
347
10
45
70
1338
|
|
GAG
NANPDCKSIL
349
10
11
17
1339
|
|
GAG
NANPDCKTIL
349
10
45
70
1340
|
|
GAG
KTILKALGPA
355
10
16
25
1341
|
|
GAG
TILKALGPAA
356
10
16
25
1342
|
|
GAG
TILRALGPGA
356
10
13
20
1343
|
|
GAG
ILKALGPAAT
357
10
16
25
1344
|
|
GAG
PAATLEEMMT
363
10
16
25
1345
|
|
GAG
AATLEEMMTA
364
10
16
25
1346
|
|
GAG
GASLEEMMTA
364
10
10
16
1347
|
|
GAG
GATLEIEMMTA
364
10
28
44
1348
|
|
GAG
RVLAEAMSQA
385
10
16
25
1349
|
|
GAG
RVLAEAMSQV
385
10
33
52
0.0058
1350
|
|
GAG
VLAEAMSQVT
386
10
20
31
1351
|
|
GAG
EAMSQVTNSA
389
10
11
17
1352
|
|
GAG
AMSQVTNSAT
390
10
10
16
1353
|
|
GAG
QMKDCIERQA
455
10
49
77
1354
|
|
GAG
FLQNRPEPTA
486
10
10
16
1355
|
|
GAG
FLQSRPEPTA
486
10
28
44
0.0013
1356
|
|
GAG
PAESFRFEET
511
10
02
67
1357
|
|
GAG
TTPSQKQEPI
522
10
09
45
1358
|
|
GAG
ETIDKDLYPL
537
10
01
25
1359
|
|
GAG
PIDKELYPLT
538
10
01
25
1360
|
|
GAG
RTENSLYPPL
538
10
01
25
1361
|
|
GAG
TIDKDLYPLA
538
10
01
25
1362
|
|
GAG
WASRELERFAL
37
11
22
34
1363
|
|
GAG
WASRELERFAV
37
11
17
27
1364
|
|
GAG
ELERFALNPGL
42
11
14
22
1365
|
|
GAG
ELERFAVNPGL
42
11
15
23
1366
|
|
GAG
LLETSEGCRQI
52
11
16
25
1367
|
|
GAG
RQILGQLQPSL
60
11
11
17
1368
|
|
GAG
LQTGSEELRSL
70
11
11
17
1369
|
|
GAG
ELRSLYNTVAT
76
11
13
20
1370
|
|
GAG
VATLYCVHQKI
84
11
12
19
1371
|
|
GAG
VATLYCVHQRI
84
11
15
23
1372
|
|
GAG
RIEVKDTKEAL
93
11
12
19
1373
|
|
GAG
PIVQNAQGQMV
154
11
14
22
1374
|
|
GAG
PIVQNLQGQMV
154
11
29
45
1375
|
|
GAG
NLQGQMVIIQAI
158
11
15
23
1376
|
|
GAG
QMVHQAISPRT
162
11
27
42
1377
|
|
GAG
MVHQAISPRTL
163
11
27
42
1378
|
|
GAG
IIQAISPRTLNA
165
11
29
45
1379
|
|
GAG
IIQALSPR1LNA
165
11
10
16
1380
|
|
GAG
AISPRTLNAWV
167
11
29
45
1381
|
|
GAG
ALSPRTLNAWV
167
11
10
16
1382
|
|
GAG
NAWVKVIEEKA
174
11
25
39
1383
|
|
GAG
NAWVKVVEEKA
174
11
27
42
1384
|
|
GAG
VIEEKAFSPEV
179
11
20
31
1385
|
|
GAG
VVEEKAFSPEV
179
11
28
44
1386
|
|
GAG
PMFSALSEGAT
191
11
44
69
1387
|
|
GAG
PMFTALSEGAT
191
11
15
23
1388
|
|
GAG
ALSEGATPQDL
195
11
58
91
1389
|
|
GAG
GATPQDLNMML
199
11
12
19
1390
|
|
GAG
GATPQDLNIML
199
11
42
66
1391
|
|
GAG
PQDLNNIMLNIV
202
11
11
17
1392
|
|
GAG
PQDLNTMLNTV
202
11
41
64
1393
|
|
GAG
MMLNIVGGIIQA
207
11
12
19
1394
|
|
GAG
TMLNTVGGIIQA
207
11
43
67
1395
|
|
GAG
MLNIVGGIIQAA
208
11
12
19
1396
|
|
GAG
MLNTVGGIIQAA
208
11
47
73
1397
|
|
GAG
IVGGIIQAAMQM
211
11
11
17
1398
|
|
GAG
TVGGIIQAAMQM
211
11
47
73
1399
|
|
GAG
HQAAMQMLKDT
215
11
33
52
1400
|
|
GAG
HQAAMQMLKET
215
11
26
41
1401
|
|
GAG
QAAMQMLKDTI
216
11
33
52
1402
|
|
GAG
QAAMQMLKETI
216
11
26
41
1403
|
|
GAG
QMLKDTINEEA
220
11
32
50
1404
|
|
GAG
QMLKETINEEA
220
11
22
34
1405
|
|
GAG
MLKDTINEEAA
221
11
32
50
1406
|
|
GAG
MLKETINEEAA
221
11
22
34
1407
|
|
GAG
EAAEWDRLIIPV
229
11
34
53
1408
|
|
GAG
EAAEWDRVHPV
229
11
14
22
1409
|
|
GAG
RLIIPVIIAGPIA
235
11
15
23
1410
|
|
GAG
GQMREPRGSDI
247
11
44
69
1411
|
|
GAG
QMREPRGSDIA
248
11
44
69
1412
|
|
GAG
GTTSTLQEQIA
259
11
11
17
1413
|
|
GAG
STLQEQIAWMT
262
11
12
19
1414
|
|
GAG
STLQEQIGWMT
262
11
27
42
1415
|
|
GAG
QIGWMTNNPPI
267
11
18
29
1416
|
|
GAG
QIGWMFSNPPI
267
11
10
16
1417
|
|
GAG
PVGDIYKRWII
281
11
17
27
1418
|
|
GAG
PVGEIYKRWII
281
11
39
61
1419
|
|
GAG
DIYKRWIILGL
284
11
17
27
1420
|
|
GAG
EIYKRWIILGL
284
11
37
58
1421
|
|
GAG
IILGLNKIVRM
290
11
56
88
1422
|
|
GAG
KIVRMYSPTSI
296
11
14
22
1423
|
|
GAG
KIVRMYSPVSI
296
11
39
61
1424
|
|
GAG
IVRMYSPTSIL
297
11
14
22
1425
|
|
GAG
IVRMYSPVSIL
297
11
40
63
1426
|
|
GAG
RMYSPTSILDI
299
11
13
20
1427
|
|
GAG
RMYSPVSILDI
299
11
38
59
1428
|
|
GAG
YVDRFFKTLRA
320
11
27
42
1429
|
|
GAG
YVDRFYKTLRA
320
11
28
44
1430
|
|
GAG
TLRAEQASQEV
327
11
12
19
1431
|
|
GAG
TLRAEQATQDV
327
11
11
7
1432
|
|
GAG
TLRAEQATQEV
327
11
24
38
1433
|
|
GAG
EQASQEVKNWM
331
11
11
17
1434
|
|
GAG
EQATQDVKNWM
331
11
15
23
1435
|
|
GAG
EQATQEVKNWM
331
11
18
28
1436
|
|
GAG
QASQEVKNWMT
332
11
11
17
1437
|
|
GAG
QATQDVKNWMT
332
11
15
23
1438
|
|
GAG
QATQEVKNWMT
332
11
18
28
1439
|
|
GAG
SQEVKNWMTET
334
11
11
17
1440
|
|
GAG
TQDVKNWMTDT
334
11
11
17
1441
|
|
GAG
TQEVKNWMTET
334
11
14
22
1442
|
|
GAG
DVKNWMTDTLL
336
11
12
19
1443
|
|
GAG
DVKNWMTETLL
336
11
11
17
1444
|
|
GAG
EVKNWMTETLL
336
11
25
39
1445
|
|
GAG
WMTDTLLVQNA
340
11
22
34
1446
|
|
GAG
WMTETLLVQNA
340
11
35
55
1447
|
|
GAG
LVQNANPDCKT
346
11
45
70
1448
|
|
GAG
VQNANPDCKSI
347
11
10
16
1449
|
|
GAG
VQNANPDCKTI
347
11
45
70
1450
|
|
GAG
KTILKALGPAA
355
11
16
25
1451
|
|
GAG
KTILRALGPGA
355
11
13
20
1452
|
|
GAG
TILKALGPAAT
356
11
16
25
1453
|
|
GAG
ILKALGPAATL
357
11
16
25
1454
|
|
GAG
ALGPAATLEEM
360
11
16
25
1455
|
|
GAG
ALGPGATLEEM
360
11
17
27
1456
|
|
GAG
PAATLEEMMTA
363
11
16
25
1457
|
|
GAG
CQGVGGPGHKA
374
11
36
56
1458
|
|
GAG
CQGVGGPSIIKA
374
11
23
36
1459
|
|
GAG
GVGGPGIIKARV
376
11
36
56
1460
|
|
GAG
GVGGIPSHKARV
376
11
19
30
1461
|
|
GAG
RVLAEAMSQVT
385
11
20
31
1462
|
|
GAG
EAMSQVTNSAT
389
11
10
16
1463
|
|
GAG
SAQQDLKGGYT
393
11
01
50
1464
|
|
GAG
TAQQDLKGGYT
393
11
01
50
1465
|
|
GAG
HQMKDCTERQA
454
11
49
77
1466
|
|
GAG
PAEPTAPPAEI
492
11
01
50
1467
|
|
GAG
PAESFRFEETT
511
11
02
67
1468
|
|
GAG
SQKQEPIDKEL
529
11
09
15
1469
|
|
GAG
ETIDKDLYPLA
537
11
01
25
1470
|
|
GAG
RTENSLYPPLT
538
11
01
25
1471
|
|
GAG
SLKSLFGNDPL
551
11
12
19
1472
|
|
NEF
RAQAEPAA
32
8
01
17
1473
|
|
NEF
AQAEPAAA
33
8
01
17
1474
|
|
NEF
PAADGVGA
41
8
IS
23
1475
|
|
NEF
PAAEGVGA
41
8
21
33
1476
|
|
NEF
AADGVGAV
42
8
11
18
1477
|
|
NEF
AAEGVGAA
42
8
10
16
1478
|
|
NEF
AAEGVGAV
42
8
17
28
1479
|
|
NEF
DLEKIIGAI
57
8
14
22
1480
|
|
NEF
GAITSSNT
62
8
32
50
1481
|
|
NEF
GALISSNT
62
8
10
16
1482
|
|
NEF
AITSSNTA
63
8
27
42
1483
|
|
NEF
ITSSNTAA
64
8
15
23
1484
|
|
NEF
AATNADCA
70
8
12
22
1485
|
|
NEF
EAQEEEEV
82
8
16
25
1486
|
|
NEF
PVRPQVPL
95
8
48
75
1487
|
|
NEF
PQVPLRPM
99
8
56
88
1488
|
|
NEF
QVPLRPMT
100
8
57
89
0.0001
1489
|
|
NEF
ALDLSHFL
111
8
11
17
1490
|
|
NEF
AVDLSIIFL
111
8
15
23
1491
|
|
NEF
FLKEKGGL
117
8
56
88
1492
|
|
NEF
SQKRQDIL
177
8
12
19
1493
|
|
NEF
QTEPAAVGV
32
9
01
17
1494
|
|
NEF
RAEPAADGV
32
9
01
17
1495
|
|
NEF
RAQAEPAAA
32
9
01
17
1496
|
|
NEF
RTEPAAVGV
32
9
01
17
1497
|
|
NEF
QAEPAAEGV
33
9
01
17
1498
|
|
NEF
QAPTAAKGV
33
9
01
17
1499
|
|
NEF
QAEPAAAGV
34
9
01
33
1500
|
|
NEF
PAADGVGAV
41
9
11
17
1501
|
|
NEF
PAAEGVGAV
41
9
12
19
1502
|
|
NEF
GVGAASQDL
45
9
11
17
1503
|
|
NEF
GVGAVSQDL
45
9
21
33
1504
|
|
NEF
GVGAVSRDL
45
9
17
27
0.0001
1505
|
|
NEF
DLEKIIGAIT
57
9
14
22
1506
|
|
NEF
GAITSSNTA
62
9
27
42
1507
|
|
NEF
AITSSNTAA
63
9
14
22
1508
|
|
NEF
ITSSNTAAT
64
9
13
20
1509
|
|
NEF
TAATNADCA
69
9
12
19
1510
|
|
NEF
ATNAECAWL
71
9
12
22
1511
|
|
NEF
NADCAWLEA
73
9
17
27
1512
|
|
NEF
PQVPLRPMT
99
9
56
88
1513
|
|
NEF
PLRPMTYKA
102
9
21
33
1514
|
|
NEF
MTYKGAFDL
106
9
12
19
1515
|
|
NEF
GAFDLSFFL
110
9
10
16
1516
|
|
NEF
RQDILDLWV
382
9
20
33
1517
|
|
NEF
RQEILDLWV
182
9
35
55
1518
|
|
NEF
ILDLWVYIIT
186
9
34
53
1519
|
|
NEF
ILDLWVYNT
186
9
19
30
1520
|
|
NEF
LTFGWCFKL
221
9
39
61
0.1400
0.1300
0.0022
0.0180
7.2000
1521
|
|
NEF
LVPVEIPREV
229
9
11
17
1522
|
|
NEF
KQAEPAAEGV
32
10
01
17
1523
|
|
NEF
RQAPTAAKGV
32
10
01
17
1524
|
|
NEF
AQAEPAAAGV
33
10
01
17
1525
|
|
NEF
GAITSSNTAA
62
10
14
22
1526
|
|
NEF
AITSSNTAAT
63
10
13
20
1527
|
|
NEF
NTAATNADCA
68
10
12
19
1528
|
|
NEF
AATNADCAWL
70
10
12
22
1529
|
|
NEF
WLEAQEEEEV
79
10
15
24
1530
|
|
NEF
EVGFPVRPQV
91
10
40
63
1531
|
|
NEF
PLRPMTYKAA
102
10
20
31
1532
|
|
NEF
PLRPMTYKGA
102
10
25
39
1533
|
|
NEF
PMTYKGAFDL
105
10
12
19
1534
|
|
NEF
LIYSKKRQEI
174
10
18
28
1535
|
|
NEF
SQKRQDILDL
177
10
12
19
1536
|
|
NEF
DILDLWVYIIT
185
10
12
19
1537
|
|
NEF
EILDLWVYIIT
185
10
22
34
1538
|
|
NEF
EILDLWVYNT
185
10
11
17
1539
|
|
NEF
WQNYTPGPGI
204
10
18
29
1540
|
|
NEF
WQNYTPGPGT
204
10
21
33
1541
|
|
NEF
WQNYTPGPGV
204
10
11
17
1542
|
|
NEF
PLTFGWCFKL
219
10
39
61
0.0350
0.0058
0.0021
0.0010
0.8400
1543
|
|
NEF
LIFGWCFKLV
221
10
35
55
0.0170
0.0880
0.0540
0.0640
6.5000
1544
|
|
NEF
KLVPVDPREV
228
10
11
17
1545
|
|
NEF
LLIIPICQIIGM
257
10
10
16
1546
|
|
NEF
LLIIPMSQIIGM
257
10
12
19
1547
|
|
NEF
QTEPAAVGVGA
32
11
01
17
1548
|
|
NEF
RAEPAADGVGA
32
11
01
17
1549
|
|
NEF
RAQAEPAAAGV
32
11
01
17
1550
|
|
NEF
RTEPAAVGVGA
32
11
01
17
1551
|
|
NEF
QAEPAAEGVGA
33
11
01
17
1552
|
|
NEF
QAPTAAKGVGA
33
11
01
17
1553
|
|
NEF
QAEPAAAGVGA
34
11
01
33
1554
|
|
NEF
AVSRDLEKIIGA
48
11
11
17
1555
|
|
NEF
GAITSSNTAAT
62
11
13
20
1556
|
|
NEF
ITSSNTAATNA
64
11
12
19
1557
|
|
NEF
TAATNADCAWL
69
11
12
19
1558
|
|
NEF
ATNADCAWLEA
71
11
12
22
1559
|
|
NEF
AQEEEEVGFPV
83
11
17
27
1560
|
|
NEF
PVRPQVPLRPM
95
11
47
73
1561
|
|
NEF
QVPLRPMTYKA
100
11
20
31
1562
|
|
NEF
FLKEKGGLDGL
117
11
26
41
1563
|
|
NEF
FLKEKGGLEGL
117
11
29
45
1564
|
|
NEF
GLIYSKKRQEI
173
11
18
28
1565
|
|
NEF
LIYSKKRQEIL
174
11
18
28
1566
|
|
NEF
YTPGP6IRYPL
207
11
16
25
1567
|
|
NEF
YTPGPCITRFPL
207
11
13
20
1568
|
|
NEF
PLTFGWCFKLV
219
11
35
55
1569
|
|
NEF
CLLHPMSQIIGM
256
11
10
16
1570
|
|
POL
LAFPQGEA
6
8
12
19
1571
|
|
POL
LAFPQGKA
6
8
12
19
1572
|
|
POL
LAFQQGEA
6
8
16
25
1573
|
|
POL
QTRANSPT
21
8
28
45
1574
|
|
POL
PTRRSLQV
30
8
14
22
I575
|
|
POL
QTRANSPT
35
8
01
33
1S76
|
|
POL
PTSRELQV
36
8
01
33
1577
|
|
POL
GADRQGIV
70
8
01
20
1578
|
|
POL
GTLNCPQI
80
8
01
33
1579
|
|
POL
PTFNFPQI
80
8
01
33
1580
|
|
POL
ITLWQRPL
90
8
47
73
1581
|
|
POL
TLWQRPLV
91
8
49
77
1582
|
|
POL
WQRPLVTI
93
8
21
33
1583
|
|
POL
WQRPLVTV
93
8
19
30
1584
|
|
POL
TIKIGGQL
99
8
17
27
1585
|
|
POL
TVKIGGQL
99
8
11
17
1586
|
|
POL
GQLIEALL
104
8
10
16
1587
|
|
POL
GQLKEALL
104
8
34
53
1588
|
|
POL
LIEALLDT
106
8
10
16
1589
|
|
POL
EALLDTGA
108
8
61
95
1590
|
|
POL
DTGADDTV
112
8
63
98
1591
|
|
POL
TVLEDINL
118
8
13
20
1592
|
|
POL
TVLEEINL
118
8
15
23
1593
|
|
POL
GIGGFIKV
136
8
64
100
1594
|
|
POL
KVRQYDQI
142
8
41
64
1595
|
|
POL
RQYDQILI
144
8
20
31
1596
|
|
POL
RQYDQIPI
144
8
13
20
1597
|
|
POL
EICGHKAI
152
8
19
30
1598
|
|
POL
EICGKKAI
152
8
24
38
1599
|
|
POL
KAIGTVLV
157
8
48
75
1600
|
|
POL
GTVLVGPT
160
8
60
94
1601
|
|
POL
VLVGPTPV
162
8
53
83
1602
|
|
POL
NIIGRNLL
170
8
26
41
1603
|
|
POL
NIIGRNML
170
8
31
48
1604
|
|
POL
IIGRNLLT
171
8
26
41
1605
|
|
POL
IIGRNMLT
171
8
30
47
1606
|
|
POL
LLTQIGCT
176
8
21
33
1607
|
|
POL
MLTQIGCT
176
8
18
28
1608
|
|
POL
MLTQLGCT
176
8
10
16
1609
|
|
POL
LTQIGCTL
177
8
42
66
1610
|
|
POL
LTQLGCTL
177
8
15
23
1611
|
|
POL
PISPIETV
187
8
57
89
1612
|
|
POL
PVKLKPGM
195
8
56
88
1613
|
|
POL
KVKQWPLT
207
8
49
77
1614
|
|
POL
LTEEKIKA
213
8
56
88
1615
|
|
POL
KIKALTEI
217
8
28
44
1616
|
|
POL
KIKALVEI
217
8
15
23
1617
|
|
POL
KALTEICT
219
8
12
19
1618
|
|
POL
KALVEICT
219
8
15
24
1619
|
|
POL
LVEICTEM
221
8
15
24
1620
|
|
POL
EMEKEGKI
229
8
42
66
1621
|
|
POL
AIKKKDST
251
8
59
92
1622
|
|
POL
STKWRKLV
257
8
59
92
1623
|
|
POL
KLVDFREL
262
8
63
98
1624
|
|
POL
RTQDPWEV
272
8
55
86
1625
|
|
POL
QLGIPHPA
280
8
56
89
1626
|
|
POL
GIPHPAGL
282
8
56
89
1627
|
|
POL
GLKKKKSV
288
8
52
81
1628
|
|
POL
TVLDVGDA
296
8
58
91
1629
|
|
POL
DAYESVPL
302
8
55
86
1630
|
|
POL
TAFYIPSI
317
8
37
58
1631
|
|
POL
TAFIIPSI
317
8
13
20
1632
|
|
POL
GIRYQYNV
330
8
52
81
1633
|
|
POL
PAIFQSSM
346
8
42
66
1634
|
|
POL
AIFQSSMT
347
8
39
61
1635
|
|
POL
FQSSMTKI
349
8
38
59
1636
|
|
POL
KQNPDIVI
362
8
14
22
1637
|
|
POL
DIVIYQYM
366
8
18
28
1638
|
|
POL
EIVIYQYM
366
8
24
38
1639
|
|
POL
DLYVGSDL
375
8
63
98
1640
|
|
POL
YVGSDLEI
377
8
58
91
1641
|
|
POL
IILLKWGFT
397
8
22
34
1642
|
|
POL
HLLRWGFT
397
8
25
39
1643
|
|
POL
LLKWGFTT
398
8
23
36
1644
|
|
POL
LLRWGFTT
398
8
24
38
1645
|
|
POL
IlQKEPPFL
410
8
62
97
1646
|
|
POL
FLWMGYEL
416
8
64
100
1647
|
|
POL
ELIIPDKWT
422
8
60
94
1648
|
|
POL
WTVQPIQL
428
8
28
44
1649
|
|
POL
WTVQPIVL
428
8
13
20
1650
|
|
POL
TVNDIQKL
442
8
62
97
1651
|
|
POL
IQKLVGKL
446
8
62
97
1652
|
|
POL
LVGKLNWA
449
8
61
95
1653
|
|
POL
KLNWASQI
452
8
61
95
1654
|
|
POL
QIYAGIKV
458
8
27
43
1655
|
|
POL
QIYPGIKV
458
8
27
43
1656
|
|
POL
KVKQLCKL
464
8
29
45
1657
|
|
POL
KVRQLCKL
464
8
19
30
1658
|
|
POL
KLLRGAKA
470
8
25
40
1659
|
|
POL
KLLRGTKA
470
8
24
38
1660
|
|
POL
LLRGAKAL
471
8
30
47
1661
|
|
POL
LLRGTKAL
471
8
24
38
1662
|
|
POL
GAKALTDI
474
8
25
39
1663
|
|
POL
GTKALTEV
474
8
19
30
1664
|
|
POL
ALTDIVPL
477
8
21
33
1665
|
|
POL
ALTEVIPL
477
8
16
25
1666
|
|
POL
LTDIVPLT
478
8
23
36
1667
|
|
POL
LTEVIPLT
478
8
16
25
1668
|
|
POL
IVPLTEEA
481
8
13
20
1669
|
|
POL
VIPLTEEA
481
8
11
17
1670
|
|
POL
PLTEEAEL
483
8
30
47
1671
|
|
POL
ELAENREI
491
8
57
89
1672
|
|
POL
LAENREIL
492
8
57
89
1673
|
|
POL
KQGQDQWT
523
8
15
23
1674
|
|
POL
KQGQGQWT
523
8
25
39
1675
|
|
POL
YQEPFKNL
534
8
43
67
1676
|
|
POL
NLKTGKYA
540
8
58
92
1677
|
|
POL
KTGKYAKM
542
8
19
30
1678
|
|
POL
KTGKYARM
542
8
13
21
1679
|
|
POL
RTAIITNDV
550
8
11
17
1680
|
|
POL
IINDVKQL
553
8
49
77
1681
|
|
POL
DVKQLTEA
556
8
33
52
1682
|
|
POL
LTEAVQKI
560
8
34
53
1683
|
|
POL
EAVQKIAT
562
8
11
17
1684
|
|
POL
KIATESIV
566
8
14
22
1685
|
|
POL
IATESIVI
567
8
14
22
1686
|
|
POL
SIVIWGKT
571
8
42
66
1687
|
|
POL
KLPIQKET
582
8
20
31
1688
|
|
POL
RLPIQKET
582
8
26
41
1689
|
|
POL
IQKETWEA
585
8
15
23
1690
|
|
POL
IQKETWET
585
8
27
42
1691
|
|
POL
ETWEAWWT
588
8
11
17
1692
|
|
POL
ETWETWWT
588
8
22
34
1693
|
|
POL
WIDYWQAT
594
8
15
23
1694
|
|
POL
WTEYWQAT
594
8
24
38
1695
|
|
POL
WIPEWEFV
602
8
52
84
1696
|
|
POL
FVNTPPLV
608
8
54
86
1697
|
|
POL
NTPPLVKL
610
8
57
89
1698
|
|
POL
LVKLWYQL
614
8
58
91
1699
|
|
POL
KLWYQLET
616
8
12
19
1700
|
|
POL
YQLEKDPI
619
8
14
22
1701
|
|
POL
YQLEKEPI
619
8
31
48
1702
|
|
POL
YQLETEPI
619
8
11
17
1703
|
|
POL
QLEKEPIV
620
8
16
25
1704
|
|
POL
ETFYVDGA
630
8
55
86
1705
|
|
POL
AANRETKL
637
8
30
47
1706
|
|
POL
KLGKAGYV
643
8
36
56
1707
|
|
POL
RQKVVSLT
655
8
19
30
1708
|
|
POL
KVVSLTET
657
8
11
17
1709
|
|
POL
VVSLTDTT
658
8
10
16
1710
|
|
POL
VVSLTETT
658
8
11
17
1711
|
|
POL
TTNQKTEL
664
8
55
86
1712
|
|
POL
NQKTELIIA
666
8
12
19
1713
|
|
POL
NQKIELQA
666
8
42
66
1714
|
|
POL
ELQAIIILA
670
8
16
25
1715
|
|
POL
ELQAIYLA
670
8
12
19
1716
|
|
POL
LQAIIILAL
671
8
16
25
1717
|
|
POL
LQAIYLAL
671
8
12
19
1718
|
|
POL
LALQDSGL
676
8
27
42
1719
|
|
POL
LQDSGLEV
678
8
27
42
1720
|
|
POL
LQDSGSEV
678
8
25
39
1721
|
|
POL
GLEVNIVT
682
8
26
41
1722
|
|
POL
IVTDSQYA
687
8
61
95
1723
|
|
POL
VTDSQYAL
688
8
59
92
1724
|
|
POL
SQYALGII
691
8
59
92
1725
|
|
POL
YALGIIQA
693
8
58
91
1726
|
|
POL
NQIIEQLI
711
8
24
38
1727
|
|
POL
SQIIEQLI
711
8
20
31
1728
|
|
POL
QLIKKEKV
716
8
28
44
1729
|
|
POL
WVPAIIKGI
727
8
63
98
1730
|
|
POL
GIGGNEQV
733
8
59
92
1731
|
|
POL
QVDKLVSA
739
8
16
25
1732
|
|
POL
SAGIRKVL
745
8
15
23
1733
|
|
POL
GIRKVLFL
747
8
SI
80
1734
|
|
POL
KVLFLDGI
750
8
50
78
1735
|
|
POL
FLDGIDKA
753
8
55
86
1736
|
|
POL
AMASDFNL
773
8
45
70
1737
|
|
POL
PIVAKEIV
782
8
26
41
1738
|
|
POL
PVVAKEIV
782
8
28
44
1739
|
|
POL
IVAKEIVA
783
8
26
41
1740
|
|
POL
VVAKEIVA
783
8
31
48
1741
|
|
POL
CQLKGEAM
795
8
53
83
1742
|
|
POL
QVDCSPGI
805
8
57
89
1743
|
|
POL
GIWQLDCT
811
8
59
92
1744
|
|
POL
WQLDCTIIL
813
8
61
95
1745
|
|
POL
CTIILEGKI
817
8
35
55
1746
|
|
POL
CTHLEGKV
817
8
26
41
1747
|
|
POL
IILEGKIIL
819
8
31
48
1748
|
|
POL
IILEGKVIL
819
8
23
36
1749
|
|
POL
IILVAVIIV
824
8
30
47
1750
|
|
POL
VILVAVIIV
824
8
24
38
1751
|
|
POL
ILVAVHVA
825
8
54
84
1752
|
|
POL
VASGYIEA
831
8
52
81
1753
|
|
POL
PAETGQET
842
8
58
91
1754
|
|
POL
GQETAYFI
846
8
31
48
1755
|
|
POL
GQETAYFL
846
8
26
41
1756
|
|
POL
TAYIILKL
849
8
32
50
1757
|
|
POL
TAYFLLKL
849
8
27
42
1758
|
|
POL
KLAGRWPV
855
8
59
92
1759
|
|
POL
FTSAAVKA
873
8
28
44
1760
|
|
POL
FTSTTVKA
873
8
14
22
1761
|
|
POL
AACWWAGI
880
8
32
50
1762
|
|
POL
GIKQEFGI
886
8
22
34
1763
|
|
POL
GIQQEFGI
886
8
11
17
1764
|
|
POL
SQGVVESM
899
8
53
83
1765
|
|
POL
DQAEIILKT
919
8
46
72
1766
|
|
POL
EQAEIILKT
919
8
13
20
1767
|
|
POL
QAEHLKTA
920
8
59
92
1768
|
|
POL
IILKTAVQM
923
8
57
89
1769
|
|
POL
KTAVQMAV
925
8
57
89
1770
|
|
POL
AVQMAVFI
927
8
60
94
1771
|
|
POL
RIIDIIAT
951
8
29
45
1772
|
|
POL
RIVDIIAT
951
8
12
19
1773
|
|
POL
IIASDIQT
955
8
15
23
1774
|
|
POL
IIATDIQT
955
8
41
64
1775
|
|
POL
LQKQIIKI
965
8
13
20
1776
|
|
POL
LQKQITKI
965
8
36
56
1777
|
|
POL
LLWKGEGA
993
8
62
97
1778
|
|
POL
VIQDNSDI
1003
8
37
58
1779
|
|
POL
VIQDNSEI
1003
8
12
19
1780
|
|
POL
KVVPRRKA
1011
8
52
81
1781
|
|
POL
KVVPRRKV
1011
8
11
17
1782
|
|
POL
QMAGDDCV
1027
8
44
69
1783
|
|
POL
MAGDDCVA
1028
8
44
69
1784
|
|
POL
NLAFPQGEA
5
9
10
16
1785
|
|
POL
NLAFQQGEA
5
9
16
25
1786
|
|
POL
EQTRANSPT
20
9
26
41
1787
|
|
POL
SQTRANSPT
34
9
01
33
1788
|
|
POL
QTRANSPTT
35
9
01
33
1789
|
|
POL
EAGADRQGT
64
9
10
16
1790
|
|
POL
GQRQGTVSL
69
9
01
17
1791
|
|
POL
GTTLNFPQI
79
9
01
17
1792
|
|
POL
AISLSLPQI
80
9
01
33
1793
|
|
POL
GTLNCPQIT
80
9
01
33
1794
|
|
POL
PTFNFPQIT
80
9
01
33
1795
|
|
POL
QITLWQRPL
89
9
47
73
1796
|
|
POL
ITLWQRPLV
90
9
47
73
1797
|
|
POL
TLWQRPLVT
91
9
39
61
0.0185
0.0002
0.0040
0.0002
0.0140
1798
|
|
POL
VTIKIGGQL
98
9
17
27
1799
|
|
POL
VTVKIGGQL
98
9
11
17
1800
|
|
POL
KIGGQLKEA
101
9
23
36
1801
|
|
POL
QLIEALLDT
105
9
10
16
1802
|
|
POL
QLKEALLDT
105
9
34
53
1803
|
|
POL
LLDTGADDT
110
9
63
98
1804
|
|
POL
DTGADDTVL
112
9
61
95
1805
|
|
POL
DTVLEDINL
117
9
13
20
1806
|
|
POL
DTVLEEINL
117
9
14
22
1807
|
|
POL
MIGGIGGFI
133
9
62
97
0.0025
1808
|
|
POL
KVRQYDQIL
142
9
21
33
0.0001
1809
|
|
POL
LIEICGIIKA
150
9
10
16
1810
|
|
POL
LIEICGKKA
150
9
13
20
1811
|
|
POL
TVLVGPTPV
161
9
53
83
0.0047
1812
|
|
POL
LVGPTPVNI
163
9
54
84
0.0110
0.0280
0.5200
0.0013
0.5900
1813
|
|
POL
PVNIIGRNL
168
9
26
41
0.0001
1814
|
|
POL
PVNIIGRNM
168
9
24
38
1815
|
|
POL
NIIGRNLLT
170
9
26
41
1816
|
|
POL
NIIGRNMLT
170
9
30
47
1817
|
|
POL
NLLIQIGCT
175
9
21
33
1818
|
|
POL
NMLTQIUCT
175
9
18
28
1819
|
|
POL
NMLTQLGCT
175
9
10
16
1820
|
|
POL
LLTQIGCTL
176
9
21
33
0.0002
1821
|
|
POL
MLTQIGCTL
176
9
18
28
1822
|
|
POL
MLTQLGCTL
176
9
10
16
1823
|
|
POL
TLNFPISPI
183
9
61
97
0.0660
0.0029
9.3000
0.0019
0.7000
1824
|
|
POL
PIETVPVKL
190
9
53
83
0.0001
1825
|
|
POL
PLTEEKIKA
212
9
54
84
1826
|
|
POL
LTEEKIKAL
213
9
56
88
1827
|
|
POL
ALVEICTEM
220
9
15
23
0.0230
0.0230
0.0710
0.0140
0.0140
1828
|
|
POL
FAIKKKDST
250
9
59
92
1829
|
|
POL
TQDFWEVQL
273
9
55
86
1830
|
|
POL
VQLGIPIIPA
279
9
54
84
1831
|
|
POL
GLKKKKSVT
288
9
49
77
1832
|
|
POL
VTVLDVGDA
295
9
57
89
1833
|
|
POL
DVGDAYFSV
299
9
54
84
0.0005
1834
|
|
POL
YTAFTIPSI
316
9
37
58
0.1900
0.7100
1.1000
0.5300
2.4000
1835
|
|
POL
YTAFTIPST
316
9
13
20
1836
|
|
POL
TIPSINNET
320
9
37
58
1837
|
|
POL
TIPSTNNET
320
9
14
22
1838
|
|
POL
SINNETPGI
323
9
32
50
1839
|
|
POL
STNNETPGI
323
9
11
17
1840
|
|
POL
GIRYQYNYL
330
9
52
81
0.0001
1841
|
|
POL
PQGWKGSPA
339
9
59
92
1842
|
|
POL
PAIFQSSMT
346
9
39
61
1843
|
|
POL
FQSSMTKIL
349
9
38
59
1844
|
|
POL
VIYQYMDDL
368
9
51
80
0.0004
1845
|
|
POL
YQYMDDLYV
370
9
61
95
1846
|
|
POL
DLEIGQIIRA
381
9
28
44
1847
|
|
POL
DLEIGQIIRT
381
9
21
33
1848
|
|
POL
EIGQIIRAKI
383
9
26
41
1849
|
|
POL
EIGQIIRTKI
383
9
21
33
1850
|
|
POL
KIEELREIIL
390
9
19
30
1851
|
|
POL
KIEELRQIIL
390
9
17
27
0.0001
1852
|
|
POL
HLLKWGFTT
397
9
22
34
1853
|
|
POL
HLLRWGFTT
397
9
24
38
1854
|
|
POL
ELHPDKWTV
422
9
60
94
0.0001
1855
|
|
POL
QLPEKDSWT
434
9
13
20
1856
|
|
POL
VLPEKDSWT
434
9
13
20
1857
|
|
POL
WTVNDIQKL
441
9
62
97
0.0001
1858
|
|
POL
TVNDIQKLV
442
9
61
95
0.0001
1859
|
|
POL
DIQKLVGKL
445
9
62
97
0.0001
1860
|
|
POL
KLVGKLNWA
448
9
61
95
0.0840
0.3400
1.7000
0.0930
0.0130
1861
|
|
POL
WASQIYAGI
455
9
27
42
0.0020
1862
|
|
POL
WASQIYPGI
455
9
29
45
1863
|
|
POL
SQIYAGIKV
457
9
27
42
1864
|
|
POL
SQIYPGIKV
457
9
27
42
1865
|
|
POL
YAGIKVKQL
460
9
18
28
1866
|
|
POL
KVKQLCKLL
464
9
28
44
1867
|
|
POL
KVRQLCKLL
464
9
19
30
1868
|
|
POL
QLCKLLRGA
467
9
25
39
1869
|
|
POL
QLCKLLRGT
467
9
21
33
1870
|
|
POL
KLLRGAKAL
470
9
25
40
1871
|
|
POL
KLLRGTKAL
470
9
24
38
0.0069
1872
|
|
POL
LLRGAKALT
471
9
30
47
1873
|
|
POL
LLRGTKALT
471
9
24
38
1874
|
|
POL
GAKALTDIV
474
9
24
38
1875
|
|
POL
GTKALTEVI
474
9
11
17
1876
|
|
POL
KALTDIVPL
476
9
21
33
1877
|
|
POL
KALTEVIPL
476
9
16
25
1878
|
|
POL
ALTDIVPLT
477
9
21
33
1879
|
|
POL
ALTIWIPLT
477
9
16
25
1880
|
|
POL
DIVPLTEEA
480
9
13
20
1881
|
|
POL
EVIPLTEEA
480
9
11
17
1882
|
|
POL
LTEEAELEL
484
9
37
58
1883
|
|
POL
ELAENREIL
491
9
57
89
0.0001
1884
|
|
POL
ILKEPVIIGV
498
9
41
64
0.0055
1885
|
|
POL
GQDQWIYQI
525
9
13
20
1886
|
|
POL
GQGQWTYQI
525
9
25
39
1887
|
|
POL
YAKMRTAlIT
546
9
10
16
1888
|
|
POL
YARMRGAIIT
546
9
13
20
1889
|
|
POL
IITNDVKQLT
553
9
43
67
1890
|
|
POL
DVKQLTEAV
556
9
33
52
0.0001
1891
|
|
POL
QLTEAVQKI
559
9
34
53
0.0007
1892
|
|
POL
LWAVQKIA
560
9
26
41
1893
|
|
POL
VQKIATESI
564
9
14
22
1894
|
|
POL
KIATESIVI
566
9
14
22
1895
|
|
POL
KTPKFKLPI
577
9
17
27
1896
|
|
POL
KTPKFRLPI
577
9
29
45
1897
|
|
POL
PIQKETWEA
584
9
15
23
1898
|
|
POL
PIQKETWET
584
9
27
42
1899
|
|
POL
PLVKLWYQL
613
9
54
84
0.0002
1900
|
|
POL
YQLEKEPIV
619
9
16
25
1901
|
|
POL
IVGAETFYV
626
9
28
44
0.0099
1902
|
|
POL
ETFYVDGAA
630
9
51
80
1903
|
|
POL
GAANRETKL
636
9
30
47
1904
|
|
POL
KLGKAGYVT
643
9
36
56
0.0002
1905
|
|
POL
VTDRGRQKV
650
9
30
47
1906
|
|
POL
KVVSLTETT
657
9
11
17
1907
|
|
POL
LTDTTNQKT
661
9
19
30
1908
|
|
POL
LTETTNQKT
661
9
25
39
1909
|
|
POL
DTTNQKTEL
663
9
26
41
1910
|
|
POL
ETTNQKTEL
663
9
29
45
1911
|
|
POL
NQKTELHAI
666
9
12
19
1912
|
|
POL
NQKTELQAI
666
9
42
66
1913
|
|
POL
KTELQAIIIL
668
9
15
23
1914
|
|
POL
KTELQAIYL
668
9
12
19
1915
|
|
POL
ELQAIIILAL
670
9
16
25
0.0001
1916
|
|
POL
ELQAIYLAL
670
9
12
19
1917
|
|
POL
IILALQDSGL
675
9
15
23
0.0005
1918
|
|
POL
ALQDSGLEV
677
9
27
42
0.0083
1919
|
|
POL
ALQDSGSEV
677
9
25
39
1920
|
|
POL
NIVTDSQYA
686
9
61
95
1921
|
|
POL
IVTDSQYAL
687
9
59
92
0.0024
1922
|
|
POL
LVNQIIEQL
709
9
19
30
1923
|
|
POL
LVSQIIEQL
709
9
19
30
1924
|
|
POL
EQLIKKEKV
715
9
28
44
1925
|
|
POL
LIKKEKVYL
717
9
35
55
0.0001
1926
|
|
POL
KVYLAWVPA
722
9
20
32
1927
|
|
POL
KVYLSWVPA
722
9
23
37
1928
|
|
POL
EQVDKLVSA
738
9
16
25
1929
|
|
POL
LVSAGIRKV
743
9
15
23
0.0001
1930
|
|
POL
LVSSGIRKV
743
9
26
41
1931
|
|
POL
RAMASDFNL
772
9
41
64
0.0230
0.0370
0.0004
0.0710
0.0130
1932
|
|
POL
PIVAKEIVA
782
9
25
39
1933
|
|
POL
PYVAKEIVA
782
9
28
44
1934
|
|
POL
VASCDKCQL
789
9
43
67
1935
|
|
POL
GQVDCSPGI
804
9
57
89
1936
|
|
POL
CTHLEGKII
817
9
35
55
1937
|
|
POL
CTIILEGKVI
817
9
26
41
1938
|
|
POL
HLEGKIILV
819
9
31
48
0.0010
1939
|
|
POL
lILEGKVILV
819
9
23
36
0.0006
1940
|
|
POL
KIILVAVHV
823
9
30
47
0.0002
1941
|
|
POL
KVILVAVHV
823
9
23
36
0.0001
1942
|
|
POL
IILVAVIIVA
824
9
30
47
1943
|
|
POL
VILVAVIIVA
824
9
23
36
1944
|
|
POL
AVIIVASGYI
828
9
53
83
1945
|
|
POL
IIVASGYIEA
830
9
52
81
1946
|
|
POL
YIEAEVIPA
835
9
53
83
1947
|
|
POL
EAEVIPAET
837
9
62
98
1948
|
|
POL
PAETGQETA
842
9
58
91
1949
|
|
POL
GQETAYFIL
846
9
31
48
1950
|
|
POL
GQETAYFLL
846
9
26
41
1951
|
|
POL
ETAYFILKL
848
9
31
48
1952
|
|
POL
ETAYFLLKL
848
9
27
42
1953
|
|
POL
TAYFILKLA
849
9
32
50
1954
|
|
POL
TAYFLLKLA
849
9
27
42
1955
|
|
POL
LAGRWPVKT
856
9
14
22
1956
|
|
POL
LAGRWPVKV
856
9
30
47
1957
|
|
POL
HTDNGSNFT
866
9
49
77
1958
|
|
POL
FTSAAVKAA
873
9
27
42
1959
|
|
POL
FTSTTVKAA
873
9
14
22
1960
|
|
POL
AVKAACWWA
877
9
32
50
1961
|
|
POL
TVKAACWWA
877
9
23
36
1962
|
|
POL
KAACWWAGI
879
9
31
49
0.0180
0.0040
0.1200
0.0230
0.0150
1963
|
|
POL
VVESMNKEL
902
9
48
75
1964
|
|
POL
SMNKELKKI
905
9
53
83
1965
|
|
POL
ELKKIIGQV
909
9
57
89
0.0001
1966
|
|
POL
IIGQVRDQA
913
9
44
69
1967
|
|
POL
IIGQVREQA
913
9
13
20
1968
|
|
POL
QVRDQAEHL
916
9
48
75
0.0001
1969
|
|
POL
QVREQAEIIL
916
9
13
20
1970
|
|
POL
DQAEIILKTA
919
9
46
72
1971
|
|
POL
EQAEIILKTA
919
9
13
20
1972
|
|
POL
QAEIILKTAV
920
9
59
92
1973
|
|
POL
IILKTAVQMA
923
9
57
89
0.0033
1974
|
|
POL
TAVQMAVFI
926
9
59
92
1975
|
|
POL
SAGERIIDI
947
9
41
64
1976
|
|
POL
SAGERIYDI
947
9
14
22
1977
|
|
POL
IIDIIASDI
952
9
12
19
1978
|
|
POL
IIDIIATDI
952
9
29
45
1979
|
|
POL
IVDIIATDI
952
9
12
19
1980
|
|
POL
DIIASDIQT
954
9
15
23
1981
|
|
POL
DIIATDIQT
954
9
40
63
1982
|
|
POL
ATDIQTKEL
957
9
35
55
1983
|
|
POL
QTKELQKQI
961
9
46
72
1984
|
|
POL
ELQKQIIKI
964
9
13
21
1985
|
|
POL
ELQKQITKI
964
9
34
54
1986
|
|
POL
IIKIQNFRV
969
9
12
19
1987
|
|
POL
ITKIQNFRV
969
9
36
57
1988
|
|
POL
PIWKGPAKL
985
9
36
56
1989
|
|
POL
PLWKGPAKL
985
9
19
30
1990
|
|
POL
KLLWKGEGA
992
9
60
94
0.0002
1991
|
|
POL
LLWKGEGAV
993
9
62
97
0.0230
1992
|
|
POL
VVIQDNSDI
1002
9
37
58
0.0001
1993
|
|
POL
VVIQDNSEI
1002
9
12
19
1994
|
|
POL
IQDNSDIKV
1004
9
38
59
1995
|
|
POL
IQDNSEIKV
1004
9
12
19
1996
|
|
POL
VVPRRKAKI
1012
9
51
80
1997
|
|
POL
VVPRRKVKI
1012
9
11
17
1998
|
|
POL
IIKDYGKQM
1020
9
11
17
1999
|
|
POL
IIRDYCKQM
1020
9
50
78
2000
|
|
POL
KQMAGDDCV
1026
9
44
69
2001
|
|
POL
QMAGDDCVA
1027
9
44
69
0.0001
2002
|
|
POL
KAREFSSEQT
12
10
10
16
2003
|
|
POL
RANSPTRREL
26
10
16
25
2004
|
|
POL
RANSPTSREL
26
10
10
16
2005
|
|
POL
STNSPTSREL
32
10
01
33
2006
|
|
POL
SQTRANSPTT
34
10
01
33
2007
|
|
POL
RANSPSSREL
35
10
01
33
2008
|
|
POL
RANSPTTREL
37
10
01
50
2009
|
|
POL
GAISLSLPQI
79
10
01
17
2010
|
|
POL
GTTLNFPQIT
79
10
01
17
2011
|
|
POL
AISLSLPQIT
80
10
01
33
2012
|
|
POL
GTLNCPQITL
80
10
01
33
2013
|
|
POL
PTFNFPQITL
80
10)
01
33
2014
|
|
POL
PQITLWQRPL
88
10
47
73
2015
|
|
POL
QITLWQRPLV
89
10
47
73
2016
|
|
POL
ITLWQRPLVT
90
10
37
58
2017
|
|
POL
TLWQRPLVTI
91
10
21
33
2018
|
|
POL
TLWQRPLVTV
91
10
18
28
2019
|
|
POL
WQRPLVTIKI
93
10
14
22
2020
|
|
POL
WQRPLVTVKI
93
10
12
19
2021
|
|
POL
LVTIKIGGQL
97
10
13
20
2022
|
|
POL
KIGGQLKEAL
101
10
23
36
0.0002
2023
|
|
POL
GQLIEALLDT
104
10
10
16
2024
|
|
POL
GQLKEALLDT
104
10
34
53
2025
|
|
POL
LIEALLDTGA
106
10
10
16
2026
|
|
POL
ALLDTGADDT
109
10
61
95
2027
|
|
POL
LLDTGADDTV
110
10
63
98
0.0005
2028
|
|
POL
GADDTVLEDI
114
10
15
23
2029
|
|
POL
GADDTVLEEI
114
10
18
28
2030
|
|
POL
GADDTVLEEM
114
10
11
17
2031
|
|
POL
NLPGKWKPKM
124
10
35
55
2032
|
|
POL
KMIGGIGGFI
132
10
62
97
0.0290
0.0790
2.1000
0.0048
0.0120
2033
|
|
POL
FIKVRQYDQI
140
10
41
64
2034
|
|
POL
KVRQYDQILI
142
10
20
31
2035
|
|
POL
KVRQYDQIPI
142
10
13
20
2036
|
|
POL
RQYDQILIEI
144
10
20
31
2037
|
|
POL
RQYDQIPIEI
144
10
12
19
2038
|
|
POL
ILIEICGKKA
149
10
13
20
2039
|
|
POL
LIECGIKAI
150
10
10
16
2040
|
|
POL
LIEICGKKAI
150
10
13
20
2041
|
|
POL
EICGIIKAIGT
152
10
19
30
2042
|
|
POL
EICGKKAIGT
152
10
24
38
2043
|
|
POL
AIGTVLVGPT
158
10
52
81
2044
|
|
POL
GTVLVGPTPV
160
10
53
83
2045
|
|
POL
VLVGPTPVNI
162
10
53
83
0.0025
2046
|
|
POL
LVGPTPVNII
163
10
52
81
0.0015
2047
|
|
POL
PVNIIGRNLL
168
10
26
41
0.0002
2048
|
|
POL
PVNIIGRNML
168
10
24
38
2049
|
|
POL
IIGRNLLIQI
171
10
21
33
2050
|
|
POL
IIGRNMLTQI
171
10
18
28
2051
|
|
POL
IIGRNMLTQL
171
10
11
17
2052
|
|
POL
NLLTQIGCTL
175
10
21
33
0.0007
2053
|
|
POL
NMLTQIGCTL
175
10
18
28
2054
|
|
POL
NMLTQLGCTL
175
10
10
16
2055
|
|
POL
QIGCTLNFPI
179
10
41
64
0.0025
2056
|
|
POL
QLGCTLNFPI
179
10
16
25
2057
|
|
POL
CTLNFPISPI
182
10
60
94
0.0340
0.1800
0.3300
0.4400
0.4000
2058
|
|
POL
PISPIETVPV
187
10
56
88
0.0002
2059
|
|
POL
TVPVKLKVGM
193
10
54
84
2060
|
|
POL
KQWPLTEEKI
209
10
56
88
2061
|
|
POL
PLTEEKIKAL
212
10
54
84
0.0002
2062
|
|
POL
LTEEKIKALT
213
10
37
58
2063
|
|
POL
TEEKIKALV
213
10
15
23
2064
|
|
POL
KIKALTEICT
217
10
12
19
2065
|
|
POL
KIKALVEICT
217
10
15
23
2066
|
|
POL
KALVEICTEM
219
10
15
24
2067
|
|
POL
CTEMEKEGKI
225
10
27
42
2068
|
|
POL
KIGPENPYNT
238
10
50
78
2069
|
|
POL
RIGPENPYNT
238
10
10
16
2070
|
|
POL
RTQDFWEVQL
272
10
53
83
2071
|
|
POL
EVQLCHPHPA
278
10
54
84
2072
|
|
POL
QLGIPHPAGL
280
10
56
89
0.0002
2073
|
|
POL
PAGLKKKKSV
286
10
50
78
2074
|
|
POL
GLKKKKSVTV
288
10
49
77
0.0002
2075
|
|
POL
SVTVLDVGDA
294
10
57
89
2076
|
|
POL
PLDKDFRKYT
308
10
19
30
2077
|
|
POL
FTIVSINNET
319
10
37
58
2078
|
|
POL
FTIPSTNNET
319
10
13
20
2079
|
|
POL
PQGWKGSPAI
339
10
59
92
2080
|
|
POL
AIFQSSMTKI
347
10
36
56
2081
|
|
POL
IVIYQYMDDL
367
10
42
66
0.0007
2082
|
|
POL
DLYVGSDLEI
375
10
58
91
0.0001
2083
|
|
POL
GQIIRAKIEEL
385
10
25
39
2084
|
|
POL
GQIIRTKIEEL
385
10
20
31
2085
|
|
POL
KIEELREHLL
390
10
19
30
2086
|
|
POL
KIEELRQIILL
390
10
17
27
0.0002
2087
|
|
POL
RQIILLRWGFT
395
10
12
19
2088
|
|
POL
IIQKEPPFLWM
410
10
62
97
2089
|
|
POL
IQLPEKDSWT
433
10
13
20
2090
|
|
POL
IVLPEKDSWT
433
10
13
20
2091
|
|
POL
QLPEKDSWTV
434
10
13
20
2092
|
|
POL
VLPEKDSWTV
434
10
13
20
0.0056
2093
|
|
POL
WTVNDIQKLV
441
10
61
95
0.0001
2094
|
|
POL
KLNWASQIYA
452
10
27
42
0.0230
0.0011
0.0250
0.0006
0.0130
2095
|
|
POL
GIKVKQLCKL
462
10
28
44
2096
|
|
POL
GIKVRQLCKL
462
10
18
28
2097
|
|
POL
KQLCKLLRGA
466
10
12
19
2098
|
|
POL
KQLCKLLRGT
466
10
14
22
2099
|
|
POL
RQLCKLLRGA
466
10
13
21
2100
|
|
POL
KLLRGAKALT
470
10
25
40
2101
|
|
POL
KLLRGTKALT
470
10
24
38
2102
|
|
POL
KALTDIVPLT
476
10
21
33
2103
|
|
POL
KALTEVIPLT
476
10
16
25
2104
|
|
POL
IVPLTEEAEL
481
10
13
20
2105
|
|
POL
VIPLTEEAEL
481
10
11
17
2106
|
|
POL
PLTEEAELEL
483
10
30
47
2107
|
|
POL
LTEEAELELA
484
10
36
56
2108
|
|
POL
ELELAENREI
489
10
53
83
2109
|
|
POL
EILKEPVIIGV
497
10
41
64
0.0007
2110
|
|
POL
GVYYDPSKDL
508
10
38
59
2111
|
|
POL
IQKQGQDQWT
521
10
12
19
2112
|
|
POL
IQKQGQGQWT
521
10
15
23
2113
|
|
POL
QIYQEPFKNL
532
10
40
63
0.0002
2114
|
|
POL
YQEPFKNLKT
534
10
43
67
2115
|
|
POL
NLKTGKYAKM
540
10
18
29
2116
|
|
POL
NLKTGKYARM
540
10
13
21
2117
|
|
POL
KTGKYAKMRT
542
10
10
16
2118
|
|
POL
RMRGAIITNDV
548
10
12
19
2119
|
|
POL
GAIITNDVKQL
551
10
19
30
2120
|
|
POL
SAIITNDVKQL
551
10
16
25
2121
|
|
POL
TAHTNDVKQL
551
10
11
17
2122
|
|
POL
KQLTEAVQKI
558
10
32
51
2123
|
|
POL
QLTEAVQKIA
559
10
26
41
2124
|
|
POL
LTEAVQKIAT
560
10
11
17
2125
|
|
POL
AVQKIATESI
563
10
10
16
2126
|
|
POL
VQKIATESIV
564
10
14
22
2127
|
|
POL
ETWWTDYWQA
591
10
10
16
2128
|
|
POL
WTDYWQATWI
594
10
14
22
2129
|
|
POL
WTEYWQATWI
594
10
24
38
2130
|
|
POL
ATWIPCWEFV
600
10
51
80
0.0013
2131
|
|
POL
WIPEWEFVNT
602
10
50
81
2132
|
|
POL
FVNTPPLVKL
608
10
54
86
0.0002
2133
|
|
POL
LVKLWYQLET
614
10
11
17
2134
|
|
POL
QLEKEPIVGA
620
10
16
25
2135
|
|
POL
PIVGAETFYV
625
10
28
44
0.0002
2136
|
|
POL
GAETFYVDGA
628
10
48
75
2137
|
|
POL
YVDGAANRET
633
10
45
70
2138
|
|
POL
ETKLGKAGYV
641
10
35
55
2139
|
|
POL
YVTDRGRQKV
649
10
29
45
0.0002
2140
|
|
POL
VTDRGRQKVV
650
10
28
44
2141
|
|
POL
RQKVVSLTET
655
10
10
16
2142
|
|
POL
SLTDTTNQKT
660
10
11
17
2143
|
|
POL
SLTETTNQKT
660
10
19
30
2144
|
|
POL
TTNQKIELIIA
664
10
12
19
2145
|
|
POL
TINQKTELQA
664
10
42
66
2146
|
|
POL
KTELQAIIILA
668
10
15
23
2147
|
|
POL
KTELQAIYLA
668
10
12
19
2148
|
|
POL
LALQDSGLEV
676
10
27
42
0.0006
2149
|
|
POL
LALQDSGSEV
676
10
25
39
2150
|
|
POL
LQDSGLEVNI
678
10
27
42
2151
|
|
POL
LQDSGSEVNI
678
10
25
39
2152
|
|
POL
NIVTDSQYAL
686
10
59
92
0.0004
2153
|
|
POL
VTDSQYALGI
688
10
58
91
2154
|
|
POL
SQYALGIIQA
691
10
58
91
2155
|
|
POL
AQPDKSESEL
700
10
36
56
2156
|
|
POL
ELVNQIIEQL
708
10
18
28
2157
|
|
POL
ELVSQIIEQL
708
10
19
30
2158
|
|
POL
LVNQIIEQLI
709
10
19
30
2159
|
|
POL
LVSQIIEQLI
709
10
19
30
2160
|
|
POL
QLIKKEKVYL
716
10
28
44
0.0006
2161
|
|
POL
LIKKEKVYLA
717
10
20
31
2162
|
|
POL
LAWVPAIIKGI
725
10
22
34
2163
|
|
POL
QVDKLVSAGI
739
10
15
23
2164
|
|
POL
QVDKLVSSGI
739
10
29
45
2165
|
|
POL
KLVSAGIRKV
742
10
15
23
0.0074
2166
|
|
POL
KLVSSGIRKV
742
10
26
41
2167
|
|
POL
LYSAGIRKYL
743
10
15
23
0.0002
2168
|
|
POL
LVSSGIRKVL
743
10
26
41
2169
|
|
POL
SAGIRKVLFL
745
10
15
23
2170
|
|
POL
VLFLDGIDKA
751
10
SI
80
0.0007
2171
|
|
POL
MASDINLPPI
774
10
22
34
2172
|
|
POL
MASDFNLPPV
774
10
25
39
0.0800
0.1900
0.1800
0.1100
2.200
2173
|
|
POL
NLPPIVAKEI
779
10
26
41
2174
|
|
POL
NLPPVVAKEI
779
10
27
42
0.0007
2175
|
|
POL
IVASCDKCQL
788
10
43
67
0.0006
2176
|
|
POL
GIWQLDCTHL
811
10
59
92
0.0003
2177
|
|
POL
CTHLEGKIIL
817
10
31
48
2178
|
|
POL
CTIILEGKVIL
817
10
23
36
2179
|
|
POL
IILEGKIILVA
819
10
31
48
2180
|
|
POL
HLEGKVILVA
819
10
23
36
2181
|
|
POL
KIILVAVHVA
823
10
30
47
2182
|
|
POL
KVILVAVIIVA
823
10
22
34
2183
|
|
POL
VAVIIVASGYI
827
10
53
83
2184
|
|
POL
VASGYIEAEV
831
10
52
81
2185
|
|
POL
VIPAETGQET
840
10
58
91
2186
|
|
POL
ETGQETAYFI
844
10
31
48
2187
|
|
POL
ETGQETAYFL
844
10
26
41
2188
|
|
POL
ETAYFILKLA
848
10
31
48
2189
|
|
POL
ETAYFLLKLA
848
10
27
42
2190
|
|
POL
ILKLAGRWPV
853
10
34
53
2191
|
|
POL
LLKLAGRWPV
853
10
25
39
0.0004
2192
|
|
POL
KLAGRWIPVKT
855
10
14
22
2193
|
|
POL
KLAGRWPVKV
855
10
30
47
2194
|
|
POL
LAGRWPVKTI
856
10
13
20
2195
|
|
POL
LAGRWPVKVI
856
10
22
34
2196
|
|
POL
AAVKAACWWA
876
10
28
44
2197
|
|
POL
TTVKAACWWA
876
10
14
22
2198
|
|
POL
WAGIKQEFGI
884
10
21
33
2199
|
|
POL
WAGIQQEFGI
884
10
11
17
2200
|
|
POL
PQSQGVVESM
897
10
53
83
2201
|
|
POL
GVVESMNKEL
901
10
48
75
2202
|
|
POL
SMNKELKKII
905
10
53
83
2203
|
|
POL
KIIGQVRDQA
912
10
43
67
2204
|
|
POL
KIIGQVREQA
912
10
13
20
2205
|
|
POL
GQVRDQAEIIL
915
10
44
69
2206
|
|
POL
GQVREQAEIIL
915
10
13
20
2207
|
|
POL
DQAEIILKTAV
919
10
46
72
2208
|
|
POL
EQAEIILKTAV
919
10
13
20
2209
|
|
POL
IILKTAVQMAV
923
10
57
89
0.0005
2210
|
|
POL
KTAVQMAVFI
925
10
56
88
0.0002
2211
|
|
POL
SAGERIIDII
947
10
41
64
2212
|
|
POL
SAGERIVDII
947
10
14
22
2213
|
|
POL
RIIDIIASDI
951
10
12
19
2214
|
|
POL
RIIDIIATDI
951
10
29
45
2215
|
|
POL
RIVDIIATDI
951
10
12
19
2216
|
|
POL
IASDIQTKEL
956
10
14
22
2217
|
|
POL
IATDIQTKEL
956
10
35
55
2218
|
|
POL
IQTKELQKQI
960
10
44
69
2219
|
|
POL
QTKELQKQII
961
10
10
16
2220
|
|
POL
QTKELQKQIT
961
10
32
50
2221
|
|
POL
QIIKIQNFRV
968
10
12
19
2222
|
|
POL
QITKIQNFRV
968
10
35
55
0.0002
2223
|
|
POL
PIWKGPAKLL
985
10
35
55
2224
|
|
POL
PLWKGPAKLL
985
10
18
28
2225
|
|
POL
KLLWKGEGAV
992
10
60
94
0.0006
2226
|
|
POL
LLWKGEGAVV
993
10
61
95
0.0360
2227
|
|
POL
AVVIQDNSDI
1000
10
37
58
2228
|
|
POL
AVVIQDNSEI
1000
10
12
19
2229
|
|
POL
VIQDNSEIKV
1003
10
37
58
0.0013
2230
|
|
POL
IQDNSDIKVV
1003
10
12
19
2231
|
|
POL
IQDNSDIKVV
1004
10
38
59
2232
|
|
POL
IQDNSEIKVV
1004
10
12
19
2233
|
|
POL
DIKVVPRRKA
1009
10
39
61
2234
|
|
POL
EIKVVPRRKA
1009
10
13
20
2235
|
|
POL
KVVPRRKAKI
1011
10
51
80
2236
|
|
POL
KVVPRRKVKI
1011
10
11
17
2237
|
|
POL
VVPRRKAKII
1012
10
50
78
2238
|
|
POL
VVPRRKVKII
1012
10
11
17
2239
|
|
POL
KIIKDYGKQM
1019
10
11
17
2240
|
|
POL
KIIRDYGKQM
1019
10
50
78
2241
|
|
POL
IIKDYGKQMA
1020
10
11
17
2242
|
|
POL
IIRDYGKQMA
1020
10
49
77
2243
|
|
POL
KQMAGDDCVA
1026
10
44
69
2244
|
|
POL
GAISLSLIPIT
79
11
01
17
2245
|
|
POL
AISLSLPQITL
80
11
01
33
2246
|
|
POL
PQITLWQRPLV
88
11
47
73
2247
|
|
POL
QITLWQRPLVT
89
11
37
58
2248
|
|
POL
ITLWQRPLVTI
90
11
19
30
2249
|
|
POL
ITLWQRPLVTV
90
11
18
28
2250
|
|
POL
PLVTIKIGGQL
96
11
13
20
2251
|
|
POL
TIKIGGQLKEA
99
11
17
27
2252
|
|
POL
KIGGQLKEALL
101
11
23
36
2253
|
|
POL
QLIEALLDTGA
105
11
10
16
2254
|
|
POL
QLKEAILDTGA
105
11
34
53
2255
|
|
POL
EALLDTGADDT
108
11
60
94
2256
|
|
POL
ALLDTGADDTV
109
11
61
95
2257
|
|
POL
LLDTGADDTVL
110
11
61
95
2258
|
|
POL
NLPGKWKPKMI
124
11
35
55
2259
|
|
POL
MIGGIGGFIKY
133
11
62
97
2260
|
|
POL
FIKVRQYDQIL
140
11
21
33
2261
|
|
POL
QILIEICGKKA
148
11
13
20
2262
|
|
POL
ILIEICGKKAI
149
11
13
20
2263
|
|
POL
EICGIIKAIGTV
152
11
19
30
2264
|
|
POL
EICGKKAIGTV
152
11
23
36
2265
|
|
POL
KAIGTVLVGPT
157
11
48
75
2266
|
|
POL
TVLVGPTPVNI
161
11
53
83
2267
|
|
POL
VLVGPTPVNII
162
11
51
80
2268
|
|
POL
PTPVNIIGRNL
166
11
26
41
2269
|
|
POL
PTPVNIIGRNM
166
11
24
38
2270
|
|
POL
PVNIIGRNLLT
168
11
26
41
2271
|
|
POL
PVNIIGRNMLT
168
11
23
36
2272
|
|
POL
NIIGRNLLTQI
170
11
21
33
2273
|
|
POL
NIIGRNMLTQI
170
11
18
28
2274
|
|
POL
NIIGRNMLTQL
170
11
11
17
2275
|
|
POL
TQIGCTLNFPI
178
11
41
64
2276
|
|
POL
TQLGCTLNFPI
178
11
15
23
2277
|
|
POL
TLNFPISPIET
183
11
54
86
2278
|
|
POL
ETVPVKLKPGM
192
11
51
80
2279
|
|
POL
KLKPGMDGPKV
197
11
47
73
2280
|
|
POL
PLTEEKIKALT
212
11
35
55
2281
|
|
POL
PLTEEKIKALV
212
11
15
23
2282
|
|
POL
EMEKEGKISKI
229
11
32
50
2283
|
|
POL
PIFAIKKKDST
248
11
22
34
2284
|
|
POL
PVFAIKKKDST
248
11
37
58
2285
|
|
POL
LVDFRELNKRI
263
11
60
94
2286
|
|
POL
TQDFWEVQLGI
273
11
55
86
2287
|
|
POL
VQLGIPIPAGL
279
11
54
84
2288
|
|
POL
PAGLKKKKSVT
286
11
47
73
2289
|
|
POL
GLKKKKSVTVL
288
11
49
77
2290
|
|
POL
VLDVGDAYFSV
297
11
53
83
0.0150
2291
|
|
POL
DVGDAYFSVPL
299
11
54
84
2292
|
|
POL
PLDKDFRKVTA
308
11
19
30
2293
|
|
POL
ETPGIRYQYNV
327
11
51
80
2294
|
|
POL
VLPQGWKGSPA
337
11
58
92
2295
|
|
POL
PAIFQSSMIKI
346
11
36
56
2296
|
|
POL
AIFQSSMTKIL
347
11
36
56
2297
|
|
POL
DIVIYQYMDDL
366
11
18
28
2298
|
|
POL
EIVIYQYMDDL
366
11
24
38
2299
|
|
POL
VIYQYMDDLYV
368
11
51
80
2300
|
|
POL
YMDDLYVGSDL
372
11
61
95
2301
|
|
POL
DLEIGQIIRAKI
381
11
26
41
2302
|
|
POL
DLEIGQIIRTKI
381
11
20
31
2303
|
|
POL
RAKIEELREIIL
388
11
13
20
2304
|
|
POL
RTKIEELRQIIL
388
11
14
22
2305
|
|
POL
RQIILLRWGFTT
395
11
12
19
2306
|
|
POL
PIQLPEKDSWT
432
11
13
20
2307
|
|
POL
PIVLPEKDSWT
432
11
13
20
2308
|
|
POL
IQLPEKDSWTV
433
11
13
20
2309
|
|
POL
IVLPEKDSWTV
433
11
13
20
2310
|
|
POL
IQKLVGKLNWA
446
11
61
95
2311
|
|
POL
LVGKLNWASQI
449
11
60
94
2312
|
|
POL
WASQIYAGIKV
455
11
26
41
2313
|
|
POL
WASQIYPGIKV
455
11
27
42
2314
|
|
POL
QIYAGIKVKQL
458
11
18
29
2315
|
|
POL
QIYPGIKVKQL
458
11
11
17
2316
|
|
POL
QIYPGIKVRQL
458
11
14
22
2317
|
|
POL
GIKVKQLCKLL
462
11
27
42
2318
|
|
POL
GIKVRQLCKLL
462
11
18
28
2319
|
|
POL
QLCKLLRGAKA
467
11
24
38
2320
|
|
POL
QLCKLLRGTKA
467
11
21
33
2321
|
|
POL
LLRGAKALTDI
471
11
22
34
2322
|
|
POL
LLRGTKALTEV
471
11
18
28
2323
|
|
POL
GAKALTDIVPL
474
11
17
27
2324
|
|
POL
GTKALTEVIPL
474
11
11
17
2325
|
|
POL
LTDIVPLTEEA
478
11
13
20
2326
|
|
POL
LTEVIPLTEEA
478
11
11
17
2327
|
|
POL
DIVPLTEEAEL
480
11
13
20
2328
|
|
POL
EVIPLTEEAEL
480
11
11
17
2329
|
|
POL
PLTEEAELELA
483
11
29
45
2330
|
|
POL
ELELAENREIL
489
11
53
83
2331
|
|
POL
GVYYDPSKDLI
508
11
31
48
2332
|
|
POL
EIQKQGQDQWT
520
11
12
19
2333
|
|
POL
EIQKQGQGQWT
520
11
15
23
2334
|
|
POL
KQGQDQWTYQI
523
11
13
20
2335
|
|
POL
KQGQGQWTYQI
523
11
25
39
2336
|
|
POL
YQIYQEPFKNL
531
11
40
63
2337
|
|
POL
KTGKYAKMRTA
542
11
10
16
2338
|
|
POL
KTGKYARMRGA
542
11
13
21
2339
|
|
POL
GAIITNDVKQLT
551
11
18
28
2340
|
|
POL
SAHTNDVKQLT
551
11
12
19
2341
|
|
POL
TAIITNDVKQLT
551
11
00
16
2342
|
|
POL
IITNDVKQLTEA
553
11
32
50
2343
|
|
POL
KQLTAVQKIA
558
11
24
38
2344
|
|
POL
QLTEAVQKIAT
559
11
11
17
2345
|
|
POL
EAVQKIATESI
562
11
10
16
2346
|
|
POL
AVQKIATESIV
563
11
10
16
2347
|
|
POL
VQKIATESIVI
564
11
14
22
2348
|
|
POL
ATESIVIWGKT
568
11
16
25
2349
|
|
POL
VIWGKTPKFKL
573
11
17
27
2350
|
|
POL
VIWGKTPKFRL
573
11
29
45
2351
|
|
POL
RLPIQKETWET
582
11
18
28
2352
|
|
POL
IQKETWEAWWT
585
11
11
17
2353
|
|
POL
IQKETWETWWT
585
11
21
33
2354
|
|
POL
ETWWTDYWQAT
591
11
10
16
2355
|
|
POL
QATWIPEWEFY
599
11
51
81
2356
|
|
POL
KLWYQLEKDPI
616
11
14
22
2357
|
|
POL
KLWYQLEKEPI
616
11
31
48
2358
|
|
POL
KLWYQLETEPI
616
11
11
17
2359
|
|
POL
YQLEKEPIVGA
619
11
16
25
2360
|
|
POL
GAETFYVDGAA
628
11
44
69
2361
|
|
POL
AANRETKLGKA
637
11
30
47
2362
|
|
POL
ETKLGKAGYVT
641
11
35
55
2363
|
|
POL
YVTDRGRQKVV
649
11
27
42
2364
|
|
POL
RQKVVSLTETT
655
11
10
16
2365
|
|
POL
LTDTTNQKTEL
661
11
19
30
2366
|
|
POL
LTETTNQKTEL
661
11
25
39
2367
|
|
POL
DTTNQKTELQA
663
11
25
39
2368
|
|
POL
ETTNQKTELHA
663
11
11
17
2369
|
|
POL
ETTNQKTELQA
663
11
17
27
2370
|
|
POL
TTNQKTELHAI
664
11
12
19
2371
|
|
POL
TTNQKTELQAI
664
11
42
66
2372
|
|
POL
NQKTELQAIHL
666
11
15
23
2373
|
|
POL
NQKTELQAIYL
666
11
12
19
2374
|
|
POL
KTELQAIHLAL
668
11
15
23
2375
|
|
POL
KTELQAIYLAL
668
11
12
19
2376
|
|
POL
AIHLALQDSGL
673
11
15
23
2377
|
|
POL
HLALQDSGLEV
673
11
15
23
2378
|
|
POL
ALQDSGLLVNI
677
11
27
42
2379
|
|
POL
ALQDSGSEVNI
677
11
25
39
2380
|
|
POL
LQDSGLEVNIV
678
11
27
42
2381
|
|
POL
LQDSGSEVNIV
678
11
25
39
2382
|
|
POL
EVNIVTDSQYA
684
11
59
92
2383
|
|
POL
IVTDSQYALGI
687
11
58
91
2384
|
|
POL
VTDSQYALGII
688
11
58
91
2385
|
|
POL
QAQPDKSESEL
699
11
36
56
2386
|
|
POL
AQPDKSESELV
700
11
36
56
2387
|
|
POL
ELVNQIIEQLI
708
11
18
28
2388
|
|
POL
ELVSQIIEQLI
708
11
19
30
2389
|
|
POL
IIEQLIKKEKV
713
11
28
44
2390
|
|
POL
EQLIKKEKVYL
715
11
28
44
2391
|
|
POL
QLIKKEKVYLA
716
11
19
30
2392
|
|
POL
YLAWVPAIIKGI
724
11
22
34
2393
|
|
POL
YLSWVPAIIKGI
724
11
37
58
2394
|
|
POL
GIGGNEQVDKL
733
11
58
91
2395
|
|
POL
EQVDKLVSAGI
738
11
15
23
2396
|
|
POL
EQVDKLVSSGI
738
11
29
45
2397
|
|
POL
KLVSAGIRKVL
742
11
15
23
2398
|
|
POL
KLVSSGIRKVL
742
11
26
41
2399
|
|
POL
GIRKVLFLDGI
747
11
49
77
2400
|
|
POL
KVLFLDGIDKA
750
11
48
75
2401
|
|
POL
AMASDFNLPPI
773
11
18
28
2402
|
|
POL
AMASDFNLPPV
773
11
25
39
2403
|
|
POL
MASDFNLPPIV
774
11
20
31
2404
|
|
POL
MASDFNLPPVV
774
11
25
39
2405
|
|
POL
NLPPIVAKEIV
779
11
26
41
2406
|
|
POL
NLPPVVAKEIV
779
11
27
42
2407
|
|
POL
EIVASCDKCQL
787
11
43
67
2408
|
|
POL
QLKGEAMIIGQV
796
11
53
83
2409
|
|
POL
QVDCSPGIWQL
805
11
56
88
2410
|
|
POL
QLDCTHLEGKI
814
11
33
52
2411
|
|
POL
QLDCTIILEGKV
814
11
26
41
2412
|
|
POL
CTHLEGKIILV
817
11
31
48
2413
|
|
POL
CTIILEGKVILV
817
11
23
36
2414
|
|
POL
HLEGKIILVAV
819
11
31
48
2415
|
|
POL
HLEGKVILVAV
819
11
23
36
2416
|
|
POL
LVAVHVASGYI
826
11
47
73
2417
|
|
POL
AVIIVASGYIEA
828
11
52
81
2418
|
|
POL
HVASGYIEAEV
830
11
52
81
2419
|
|
POL
VASGYIEAEVI
831
11
52
81
2420
|
|
POL
YIEAEVIPAET
835
11
53
83
2421
|
|
POL
EVIPAETGQET
839
11
58
91
2422
|
|
POL
VIPAETGQETA
840
11
58
91
2423
|
|
POL
ETGQETAYFIL
844
11
31
48
2424
|
|
POL
ETGQETAYFLL
844
11
26
41
2425
|
|
POL
GQETAYFILKL
846
11
31
48
2426
|
|
POL
GQETAYFLLKL
846
11
26
41
2427
|
|
POL
FILKLAGRWPV
852
11
32
50
2428
|
|
POL
FLLKLAGRWPV
852
11
25
39
2429
|
|
POL
KLAGRWPVKTI
855
11
13
20
2430
|
|
POL
KLAGRWPVKVI
855
11
22
34
2431
|
|
POL
TIIITDNGSNFT
864
11
13
20
2432
|
|
POL
VIIITDNGSNFT
864
11
23
36
2433
|
|
POL
IITDNGSNFTSA
866
11
33
52
2434
|
|
POL
IITDNGSNFTST
866
11
11
17
2435
|
|
POL
SAAVKAACWWA
875
11
28
44
2436
|
|
POL
STTVKAACWWA
875
11
14
22
2437
|
|
POL
AVKAACWWAGI
877
11
10
16
2438
|
|
POL
TVKAACWWAGI
877
11
20
31
2439
|
|
POL
GIPYNPQSQGV
892
11
63
98
2440
|
|
POL
QVRDQAEIILKT
916
11
43
67
2441
|
|
POL
QVREQAEIILKT
916
11
13
20
2442
|
|
POL
QAEIILKTAVQM
920
11
57
89
2443
|
|
POL
FIIINFKRKGGI
933
11
58
91
2444
|
|
POL
GIGGYSAGERI
942
11
57
89
2445
|
|
POL
SAGERIIDIIA
947
11
40
63
2446
|
|
POL
SAGERIVDIIA
947
11
14
22
2447
|
|
POL
IIDIASDIQT
952
11
12
19
2448
|
|
POL
IIDIIATDIQT
952
11
27
42
2449
|
|
POL
IVDIIATDIQT
952
11
12
19
2450
|
|
POL
IIASDIQTKEL
955
11
14
22
2451
|
|
POL
IIATDIQTKEL
955
11
34
53
2452
|
|
POL
DIQTKLLQKQI
959
11
44
69
2453
|
|
POL
IQTKELQKQII
960
11
10
16
2454
|
|
POL
IQTKELQKQIT
960
11
30
47
2455
|
|
POL
KQIIKIQNFRV
967
11
12
19
2456
|
|
POL
KQITKIQNFRV
967
11
34
54
2457
|
|
POL
RVYYRDSRDPI
976
11
34
53
2458
|
|
POL
RVYYRDSRDPL
976
11
14
22
2459
|
|
POL
PAKLLWKGEGA
990
11
59
92
2460
|
|
POL
KLLWKGEGAVV
992
11
59
92
2461
|
|
POL
LLWKGEGAVVI
993
11
59
92
2462
|
|
POL
GAVVIQDNSDI
999
11
37
58
2463
|
|
POL
GAVVIQDNSEI
999
11
12
19
2464
|
|
POL
VVIQDNSDIKV
1002
11
37
58
2465
|
|
POL
VVIQDNSEIKV
1002
11
12
19
2466
|
|
POL
VIQDNSDIKVV
1003
11
37
58
2467
|
|
POL
VIQDNSEIKVV
1003
11
12
19
2468
|
|
POL
KVVPRRKAKII
1011
11
50
78
2469
|
|
POL
KVVPRRKVKII
1011
11
11
17
2470
|
|
POL
KIIKDYGKQMA
1019
11
11
17
2471
|
|
POL
KIIRDYGKQMA
1019
11
49
77
2472
|
|
REV
LLKTVRLI
12
8
11
17
2473
|
|
REV
AVRIIKIL
17
8
13
20
2474
|
|
REV
RQRQIHSI
52
8
11
17
2475
|
|
REV
QLPPIERL
78
8
14
22
2476
|
|
REV
QLPPLERL
78
8
37
58
2477
|
|
REV
GTSGTQGV
94
8
21
33
2478
|
|
REV
GTQQSQGT
97
8
10
16
2479
|
|
REV
PQGTETGV
101
8
05
18
2480
|
|
REV
SQGTETGV
101
8
05
18
2481
|
|
REV
LVESPAVL
114
8
11
17
2482
|
|
REV
SISERILST
58
9
10
16
2483
|
|
REV
CLGRPAEPV
67
9
10
16
2484
|
|
REV
PAEPVPLQL
71
9
21
33
2485
|
|
REV
SAEPVPLQL
71
9
12
19
2486
|
|
REV
PVPLQLPPI
74
9
11
17
2487
|
|
REV
PVPLQLPPL
74
9
35
55
2488
|
|
REV
LQLPPIERL
77
9
11
17
2489
|
|
REV
LQLPPLERL
77
9
36
56
2490
|
|
REV
QLPPLERLT
78
9
18
28
2491
|
|
REV
TQGVGSPQI
98
9
11
18
2492
|
|
REV
RARQRQIIISI
50
10
10
16
2493
|
|
REV
PLQLPPIERL
76
10
11
17
2494
|
|
REV
PLQLPPLERL
76
10
34
53
2495
|
|
REV
LQLPPLERLT
77
10
17
27
2496
|
|
REV
QLPPLERLTL
78
10
18
28
0.0001
2497
|
|
REV
GTQGVGSPQI
97
10
11
18
2498
|
|
REV
PLQLPPLERLT
76
11
15
23
2499
|
|
REV
LQLPPLERLTL
77
11
17
27
2500
|
|
REV
GTSGTQQSQGT
94
11
10
16
2501
|
|
TAT
SQPKTACT
19
8
13
20
2502
|
|
TAT
FLNKGLGI
41
8
14
22
2503
|
|
TAT
SQPRGDPT
80
8
13
20
2504
|
|
TAT
KVERETET
97
8
12
19
2505
|
|
TAT
PTGPKESKKKV
88
11
12
19
2506
|
|
VIF
QVMIVWQV
6
8
43
67
2507
|
|
VIF
IVWQVDRM
9
8
59
92
2508
|
|
VIF
WQVDRMKI
11
8
13
20
2509
|
|
VIF
WQVDRMRI
11
8
48
75
2510
|
|
VIF
KIRTWNSL
17
8
12
19
2511
|
|
VIF
RIRTWKSL
17
8
15
23
2512
|
|
VIF
RIRTWNSL
17
8
15
23
2513
|
|
VIF
LVKIIIIMYI
24
8
19
30
2514
|
|
VIF
LVKIIIIMYV
24
8
21
33
2515
|
|
VIF
IIMYVSKKA
28
8
13
20
2516
|
|
VIF
KISSEVIII
50
8
15
23
2517
|
|
VIF
KVSSEVIII
50
8
20
31
2518
|
|
VIF
RISSEVIII
50
8
15
23
2519
|
|
VIF
PLGDARLV
58
8
11
17
2520
|
|
VIF
PLGEARLV
58
8
19
30
2521
|
|
VIF
VIKTYWGL
67
8
10
16
2522
|
|
VIF
VITTYWGL
67
8
22
34
2523
|
|
VIF
VVRTYWGL
67
8
10
16
2524
|
|
VIF
VVTTYWGL
67
8
11
17
2525
|
|
VIF
TTYWGLHT
69
8
24
38
2526
|
|
VIF
HLGHGVSI
83
8
25
39
2527
|
|
VIF
HLGQGVSI
83
8
26
41
2528
|
|
VIF
GVSIEWRL
87
8
18
28
2529
|
|
VIF
STQIDPDL
100
8
12
19
2530
|
|
VIF
STQVDPGL
100
8
11
17
2531
|
|
VIF
TQIDPDLA
101
8
12
19
2532
|
|
VIF
TQVDPDLA
101
8
11
17
2533
|
|
VIF
TQVDPGLA
101
8
16
25
2534
|
|
VIF
LADQLIIIL
107
8
25
39
2535
|
|
VIF
LADQLIIIM
107
8
17
27
2536
|
|
VIF
SAIRKAIL
123
8
35
55
2537
|
|
VIF
SAIRNAIL
123
8
12
19
2538
|
|
VIF
YQAGHNKV
140
8
38
59
2539
|
|
VIF
KVGSLQYL
146
8
52
81
2540
|
|
VIF
SLQYLALA
149
8
12
19
2541
|
|
VIF
SLQYLALT
149
8
31
48
2542
|
|
VIF
LQYLALAA
150
8
12
19
2543
|
|
VIF
LQYIALKA
150
8
11
17
2544
|
|
VIF
LQYLALTA
150
8
34
53
2545
|
|
VIF
YLALIALI
152
8
28
44
2546
|
|
VIF
ALIKPKKI
157
8
10
16
2547
|
|
VIF
PLPSVKKL
168
8
21
33
2548
|
|
VIF
PLPSVRKL
168
8
14
22
2549
|
|
VIF
WQVMIVWQV
5
9
43
67
2550
|
|
VIF
MIVWQVDRM
8
9
46
72
2551
|
|
VIF
QVDRMKIRT
12
9
12
19
2552
|
|
VIF
QVDRMRINT
12
9
10
16
2553
|
|
VIF
QVDRMRIRT
12
9
31
48
2554
|
|
VIF
KIRIWNSLV
17
9
12
19
2555
|
|
VIF
RIRTWKSLV
17
9
15
23
2556
|
|
VIF
RIRTWNSLV
17
9
15
23
2557
|
|
VIF
SLVKIIIIMYI
23
9
19
30
2558
|
|
VIF
SLVKIIIIMYV
23
9
21
33
2559
|
|
VIF
EVIIIFLGDA
54
9
24
38
2560
|
|
VIF
EVHIPLGEA
54
9
25
39
2561
|
|
VIF
HIPLCDARL
56
9
13
20
2562
|
|
VIF
IIIPLGEARL
56
9
20
31
2563
|
|
VIF
PLGEARLVI
58
9
10
16
2564
|
|
VIF
LVIKTYWGL
66
9
10
16
2565
|
|
VIF
LVITFYWGL
66
9
22
34
0.0031
2566
|
|
VIF
ITTYWGLIIT
68
9
16
25
2567
|
|
VIF
IITGERDWHL
75
9
21
33
2568
|
|
VIF
QTGERDWIIL
75
9
12
19
2569
|
|
VIF
STQIDPDLA
100
9
12
19
2570
|
|
VIF
STQVDPGLA
100
9
11
17
2571
|
|
VIF
DLADQLIHL
106
9
18
28
2572
|
|
VIF
GLADQLIHM
106
9
15
23
2573
|
|
VIF
KVGSLQYLA
146
9
52
81
2574
|
|
VIF
SLQYLALAA
149
9
12
19
2575
|
|
VIF
SLQYLALKA
149
9
11
17
2576
|
|
VIF
SLQYLALTA
149
9
31
48
2577
|
|
VIF
LQYLALAAL
150
9
12
19
2578
|
|
VIF
LQYLALKAL
150
9
11
17
2579
|
|
VIF
LQYLALTAL
150
9
33
52
2580
|
|
VIF
KIKPPLPSV
164
9
19
30
2581
|
|
VIF
KTKPPLPSV
164
9
12
19
2582
|
|
VIF
PLPSVKKLT
168
9
13
20
2583
|
|
VIF
VMIVWQVDRM
7
10
44
69
2584
|
|
VIF
IVWQVDRMKI
9
10
12
19
2585
|
|
VIF
IVWQVDRMRI
9
10
47
73
2586
|
|
VIF
WQVDRMKIRT
11
10
12
19
2587
|
|
VIF
WQVDRMRINT
11
10
10
16
2588
|
|
VIF
WQVDRMRIRT
11
10
31
48
2589
|
|
VIF
RMKIRFWNSL
15
10
12
19
2590
|
|
VIF
RMRIRTWKSL
15
10
15
23
2591
|
|
VIF
KMRIRTWNSL
15
10
15
23
2592
|
|
VIF
KISSEVHIPL
50
10
14
22
2593
|
|
VIF
KVSSPVIIIPL
50
10
19
30
2594
|
|
VIF
RISSEVIIIPL
50
10
13
20
2595
|
|
VIF
IIIPLGDARLV
56
10
10
16
2596
|
|
VIF
IIIPLGEARLV
56
10
19
30
2597
|
|
VIF
RLVITTYWGL
65
10
12
19
2598
|
|
VIF
VITTYWGLIIT
67
10
16
25
2599
|
|
VIF
LQTGERDWIIL
74
10
12
19
2600
|
|
VIF
QIDPDLADQL
102
10
10
16
2601
|
|
VIF
QVDPGLADQL
102
10
14
22
2602
|
|
VIF
IVSPRCEYQA
133
10
11
17
2603
|
|
VIF
QAGIINKVGSL
141
10
38
59
2604
|
|
VIF
KVGSLQYLAL
146
10
51
80
0.0008
2605
|
|
VIF
SLQYLALAAL
149
10
12
19
2606
|
|
VIF
SLQYLALKAL
149
10
11
17
2607
|
|
VIF
SLQYLALTAL
149
10
31
48
2608
|
|
VIF
LQYLALTALI
150
10
28
44
2609
|
|
VIF
KTKGHRGSHT
188
10
16
25
2610
|
|
VIF
QVMIVWQVDRM
6
11
43
67
2611
|
|
VIF
MIVWQVDRMRI
8
11
43
67
2612
|
|
VIF
RMKIRTWNSLV
15
11
12
19
2613
|
|
VIF
RMRIRTWKSLV
15
11
15
23
2614
|
|
VIF
RMRIRTWNSLV
15
11
15
23
2615
|
|
VIF
RTWKSLVKIIIIM
19
11
14
22
2616
|
|
VIF
RTWNSLVKIIHM
19
11
24
38
2617
|
|
VIF
EVHIPLGDARL
54
11
13
20
2618
|
|
VIF
EVHIPLGEARL
54
11
20
31
2619
|
|
VIF
HIPLGEARLVI
56
11
10
16
2620
|
|
VIF
LVITTYWGLHT
66
11
16
25
2621
|
|
VIF
GLHTGERDWHL
73
11
21
33
2622
|
|
VIF
GLQTGERDWHL
73
11
12
19
2623
|
|
VIF
TQIDPDLADQL
101
11
10
16
2624
|
|
VIF
TQVDPGLADQL
101
11
13
20
2625
|
|
VIF
QIDPDLADQLI
102
11
10
16
2626
|
|
VIF
QVDPGLADQLI
102
11
14
22
2627
|
|
VIF
YQAGHNKVGSL
140
11
38
59
2628
|
|
VIF
KVGSLQYLALA
146
11
12
19
2629
|
|
VIF
KVGSLQYLALT
146
11
28
44
2630
|
|
VIF
SLQYLALTALI
149
11
27
42
2631
|
|
VIF
LIKPKKIKPPL
158
11
10
16
2632
|
|
VIF
KTKGFIRGSIITM
188
11
15
23
2633
|
|
VPR
ALELLEEL
19
8
10
16
2634
|
|
VPR
TLELLEEL
19
8
44
69
2635
|
|
VPR
AVRIIFPRI
30
8
14
22
2636
|
|
VPR
ETYGDTWA
48
8
16
25
2637
|
|
VPR
ETYGDTWT
48
8
11
17
2638
|
|
VPR
DTWAGVEA
52
8
16
25
2639
|
|
VPR
DTWEGVEA
52
8
23
36
2640
|
|
VPR
WAGVEAII
54
8
16
25
2641
|
|
VPR
GVEAIIRI
56
8
34
53
2642
|
|
VPR
IIRILQQL
60
8
42
66
2643
|
|
VPR
ILQQLLFI
63
8
37
58
2644
|
|
VPR
LLFIHFRI
67
8
44
69
2645
|
|
VPR
LLFVIIFRI
67
8
12
19
2646
|
|
VPR
CQIISRIGI
77
8
45
70
2647
|
|
VPR
WALELLEEL
18
9
09
15
2648
|
|
VPR
WTLELLEEL
18
9
42
69
0.0035
2649
|
|
VPR
LLEELKNEA
22
9
17
27
2650
|
|
VPR
LLEELKSEA
22
9
16
25
2651
|
|
VPR
EAVRHFPRI
29
9
14
22
0.0001
2652
|
|
VPR
WLHGLGQHI
38
9
20
31
2653
|
|
VPR
HIYETYGDT
45
9
17
27
2654
|
|
VPR
IIIYNTYGDT
45
9
14
22
2655
|
|
VPR
YIYETYGDT
45
9
14
22
2656
|
|
VPR
DTWAGVEAI
52
9
16
25
2657
|
|
VPR
DTWEGVEAI
52
9
20
31
2658
|
|
VPR
GVEAIIRIL
56
9
34
53
2659
|
|
VPR
AIIRILQQL
59
9
39
61
0.0150
0.1900
0.2400
0.0960
0.0730
2660
|
|
VPR
IIRILQQLL
60
9
42
66
0.0004
2661
|
|
VPR
RILQQLLFI
62
9
36
56
0.2600
0.0028
0.0800
0.1000
0.0220
2662
|
|
VPR
QLLFIIIFRI
66
9
44
69
0.0530
0.0002
0.0004
0.0023
0.0840
2663
|
|
VPR
QLLFVHFRI
66
9
10
16
2664
|
|
VPR
RIGCQHSRI
74
9
47
73
2665
|
|
VPR
RIGCRIISRI
74
9
12
19
2666
|
|
VPR
CQHSRIGII
77
9
16
25
2667
|
|
VPR
CQHSRIGIT
77
9
14
22
2668
|
|
VPR
RQRRARNGA
90
9
13
20
2669
|
|
VPR
PQREPYNEWT
10
10
29
45
2670
|
|
VPR
ELLEELKNEA
21
10
16
25
2671
|
|
VPR
ELLEELKSEA
21
10
16
25
2672
|
|
VPR
LLEELKNEAV
22
10
17
27
2673
|
|
VPR
LLEELKSEAV
22
10
16
25
2674
|
|
VPR
AVRHFPRIWL
30
10
14
22
0.0002
2675
|
|
VPR
AVRHFPRPWL
30
10
34
S3
2676
|
|
VPR
ETYGDTWAGV
48
10
16
25
0.0009
2677
|
|
VPR
ETYGDTWTGV
48
10
11
17
2678
|
|
VPR
NTYGDTWEGV
48
10
16
25
2679
|
|
VPR
DTWAGVEAII
52
10
16
25
2680
|
|
VPR
DTWEGVEAII
52
10
19
30
2681
|
|
VPR
WAGVEAIIRI
54
10
15
23
2682
|
|
VPR
EAIIRILQQL
58
10
33
52
2683
|
|
VPR
AIIRILQQLL
59
10
39
61
0.0014
2684
|
|
VPR
QQLLFIHFRI
65
10
44
69
2685
|
|
VPR
QQLLFVIIFRI
65
10
10
16
2686
|
|
VPR
PQREPYNEWTL
10
11
29
45
2687
|
|
VPR
ELLEELKNEAV
21
11
16
25
2688
|
|
VPR
ELLEELKSEAV
21
11
16
25
2689
|
|
VPR
EAVRHIPRIWL
29
11
14
22
2690
|
|
VPR
EAVRHFPRPWL
29
11
34
53
2691
|
|
VPR
GQHIYETYGDT
43
11
17
27
2692
|
|
VPR
GQIIIYNTYGDT
43
11
13
20
2693
|
|
VPR
GQYIYETYGDT
43
11
13
20
2694
|
|
VPR
WAGVEAIIRIL
54
11
15
23
2695
|
|
VPR
EAIIRILQQLL
58
11
33
52
2696
|
|
VPR
IIRILQQLLFI
60
11
33
52
2697
|
|
VPR
LQQLLFIIIFRI
64
11
44
69
2698
|
|
VPR
LQQLLFVIIPRI
64
11
10
16
2699
|
|
VPR
RIGCQHSRIGI
74
11
45
70
2700
|
|
VPR
RIGCRIISRIGI
74
11
11
17
2701
|
|
VPR
#LPGRRGRNGA
85
11
01
50
2702
|
|
VPU
LAKVDYRI
5
8
01
25
2703
|
|
VPU
LAKVDYRL
5
8
01
25
2704
|
|
VPU
KVDYRIVI
7
8
01
33
2705
|
|
VPU
KVDYRLGV
7
8
01
33
2706
|
|
VPU
RIDYRLGV
7
8
01
33
2707
|
|
VPU
ILAIVALY
12
8
12
19
2708
|
|
VPU
LAIVALVV
13
8
12
20
2709
|
|
VPU
AIVALVVA
14
8
12
19
2710
|
|
VPU
IIAIVVWT
27
8
23
36
2711
|
|
VPU
IAIVVWTI
28
8
23
36
2712
|
|
VPU
AIVVWTTV
29
8
29
45
2713
|
|
VPU
VVWTIVFI
31
8
15
23
2714
|
|
VPU
KILRQRKI
45
8
15
23
2715
|
|
VPU
RQRKIDRL
48
8
20
31
2716
|
|
VPU
DQEELSAL
79
8
13
22
2717
|
|
VPU
GVEMGHHA
91
8
01
50
2718
|
|
VPU
LAKVDYRIV
5
9
01
25
2719
|
|
VPU
KVDYRIVIV
7
9
01
33
2720
|
|
VPU
ILAIVALVV
12
9
11
17
2721
|
|
VPU
LAIVALVVA
13
9
09
15
2722
|
|
VPU
IIAIVVWTI
27
9
23
36
2723
|
|
VPU
IAIVVWTIV
28
9
20
31
2724
|
|
VPU
IVVWTIVFI
30
9
15
23
2725
|
|
VPU
IVFIEYRKI
36
9
12
19
2726
|
|
VPU
RQRKIDRLI
48
9
17
27
2727
|
|
VPU
KIDRLIDRI
52
9
14
22
2728
|
|
VPU
LIDRIRERA
58
9
12
19
2729
|
|
VPU
DQEELSALV
79
9
11
18
2730
|
|
VPU
VTLLSSSKL
94
9
01
50
2731
|
|
VPU
LAKVDYRIVI
5
10
01
25
2732
|
|
VPU
LAKVDYRLGV
5
10
01
25
2733
|
|
VPU
KVDYRIVIVA
7
10
01
33
2734
|
|
VPU
KVDYRLGVGA
7
10
01
33
2735
|
|
VPU
RIDYRLGVGA
7
10
01
33
2736
|
|
VPU
IIAIVVWTIV
27
10
20
31
2737
|
|
VPU
AIVVWTIVFI
29
10
14
22
2738
|
|
VPU
ILRQRKIDRL
46
10
15
23
2739
|
|
VPU
LVTLLSSSKL
91
10
01
50
2740
|
|
VPU
LAKVDYRIVIV
5
11
01
25
2741
|
|
VPU
KVDYRLGVGAL
7
11
01
33
2742
|
|
VPU
RIDYRLGVGAL
7
11
01
33
2743
|
|
VPU
KILRQRKIDRL
45
11
15
23
2744
|
|
VPU
ILRQRKIDRLI
46
11
13
20
2745
|
|
TABLE IX
|
|
|
HIV A03 Super Motif Peptides with Binding lnformation
|
No.
Se-
Con-
|
of
quence
serv-
|
Pro-
Posi-
Amino
Fre-
ancy
SEQ
|
tein
Sequence
tion
Acids
quency
(%)
A*0301
A*1101
A*3101
A*3301
A*6801
ID NO
|
|
ENV
SLWDQSLK
123
8
47
75
2746
|
|
ENV
QSLKPCVK
127
8
48
75
2747
|
|
ENV
AITQACPK
244
8
14
22
2748
|
|
ENV
TITQACPK
244
8
11
17
2749
|
|
ENV
VITQACPK
244
8
17
27
2750
|
|
ENV
PAGFAILK
266
8
38
59
2751
|
|
ENV
PAGYAILK
266
8
15
23
2752
|
|
ENV
AILKCNDK
270
8
20
31
2753
|
|
ENV
ILKCNDKK
271
8
12
19
2754
|
|
ENV
SVEINCTR
340
8
13
20
2755
|
|
ENV
GTAGNSSR
375
8
01
33
2756
|
|
ENV
TTHSFNCR
432
8
12
19
2757
|
|
ENV
ITLPCRIK
483
8
26
41
2758
|
|
ENV
NMWQEVGK
494
8
15
23
2759
|
|
ENV
ITGLLLTR
520
8
37
58
2760
|
|
ENV
RSELYKYK
558
8
54
84
2761
|
|
ENV
PLGVAPTK
571
8
26
41
2762
|
|
ENV
PLGVAPTR
571
8
10
16
2763
|
|
ENV
GVAPTKAK
573
8
19
30
2764
|
|
ENV
VAPTKAKR
574
8
19
30
2765
|
|
ENV
VISTRTIIR
584
8
01
50
2766
|
|
ENV
STRTIIREK
586
8
01
50
2767
|
|
ENV
RVVEREKR
587
8
32
50
2768
|
|
ENV
RVVQREKR
587
8
17
27
0.0003
0.0001
2769
|
|
ENV
ITLTVQAR
621
8
32
50
2770
|
|
ENV
EAQQIILLK
646
8
12
19
2771
|
|
ENV
KLTVWGIK
653
8
13
20
2772
|
|
ENV
QLTVWGIK
653
8
44
69
2773
|
|
ENV
GIKQLQAR
658
8
49
77
2774
|
|
ENV
LAVERYLK
667
8
26
41
2775
|
|
ENV
LAVERYLR
667
8
11
17
2776
|
|
ENV
GIWGCSGK
680
8
52
81
2777
|
|
ENV
MTWMEWER
721
8
12
19
2778
|
|
ENV
ESQNQQEK
743
8
27
42
2779
|
|
ENV
AVLSIVNR
795
8
31
48
2780
|
|
ENV
LSIVNRVR
797
8
38
59
2781
|
|
ENV
ALAWDDLR
851
8
25
39
2782
|
|
ENV
RIVELLGR
878
8
22
34
2783
|
|
ENV
IVELLGRR
879
8
22
34
2784
|
|
ENV
RLGWEGLK
894
8
10
32
2785
|
|
ENV
AVAEGTDR
928
8
31
48
2786
|
|
ENV
RAILIIIPR
945
8
13
20
2787
|
|
ENV
AILHIPRR
946
8
13
20
2788
|
|
ENV
RIRQGLER
953
8
44
69
2789
|
|
ENV
TLFCASDAK
64
9
52
81
0.0930
0.5300
0.0017
0.0013
0.0420
2790
|
|
ENV
VTENFNMWK
102
9
31
48
2791
|
|
ENV
ISLWDQSLK
122
9
47
73
0.0048
0.0890
0.0017
0.0013
0.0021
2792
|
|
ENV
SAITQACPK
243
9
14
22
2793
|
|
ENV
STITQACPK
243
9
10
16
2794
|
|
ENV
SVITQACPK
243
9
17
27
2795
|
|
ENV
FAILKCNDK
269
9
14
22
0.0002
0.0002
0.0004
0.0015
0.0027
2796
|
|
ENV
AILKCNDKK
270
9
12
19
2797
|
|
ENV
TVQCTIIGIK
290
9
28
44
0.0021
0.0460 0.0042
0.0017
0.0190
2798
|
|
ENV
TVQCTIIGIR
290
9
23
36
0.0008
0.0008
0.0880
0.0330
0.0120
2799
|
|
ENV
LAEEEVVIR
312
9
12
19
0.0002
0.0002
0.0004
0.0007
0.0002
2800
|
|
ENV
CTRPNNNTR
345
9
28
44
2801
|
|
ENV
ITTIISFNCR
431
9
11
17
2802
|
|
ENV
NANITIPCR
478
9
01
50
2803
|
|
ENV
NITLPCRIK
482
9
11
17
2804
|
|
ENV
TITLPCRIK
482
9
14
22
2805
|
|
ENV
NITGLLLTR
519
9
35
55
0.0004
0.0001
2806
|
|
ENV
STNGTETFR
537
9
01
17
2807
|
|
ENV
ELYKYKVVK
560
9
32
50
2808
|
|
ENV
GVAPTKAKR
573
9
19
30
2809
|
|
ENV
VAPTKAKRR
574
9
17
27
0.0002
0.0002
0.0004
0.0006
0.0002
2810
|
|
ENV
KAKRRVVQR
579
9
13
20
0.0002
0.0002
0.0800
0.0095
0.0002
2811
|
|
ENV
IINIIITPHR
584
9
01
50
2812
|
|
ENV
ISTRTHREK
585
9
01
50
2813
|
|
ENV
NIIITPHREK
586
9
01
50
2814
|
|
ENV
STRTIIREKR
586
9
01
50
2815
|
|
ENV
SITLTVQAR
620
9
32
50
2816
|
|
ENV
QARYLAVER
663
9
33
52
0.0009
0.0003
0.0320
0.0320
0.0007
2817
|
|
ENV
VLAVERYLK
666
9
18
28
2818
|
|
ENV
VLAVERYLR
666
9
11
17
2819
|
|
ENV
NMTWMEWER
720
9
12
19
2820
|
|
ENV
ISNWLWYIK
770
9
11
17
2821
|
|
ENV
ITKWLWYIK
770
9
16
25
2822
|
|
ENV
ITNWLWYIK
770
9
15
23
2823
|
|
ENV
IVGGLIGLR
783
9
42
66
2824
|
|
ENV
FAVLSIVNR
794
9
31
48
2825
|
|
ENV
VLSIVNRVR
796
9
38
59
2826
|
|
ENV
GIEEEGGER
829
9
12
19
2827
|
|
ENV
LALAWDDLR
850
9
25
39
2828
|
|
ENV
NLCLFSYIIR
859
9
11
17
2829
|
|
ENV
SLCLFSYIIR
859
9
31
48
2830
|
|
ENV
CLFSYIIRLR
861
9
42
66
2831
|
|
ENV
RIVELLGRR
878
9
22
34
0.0550
0.0100
0.1300
0.0021
0.0180
2832
|
|
ENV
IAVAEGTDR
927
9
31
48
0.0004
0.0003
0.0003
0.0004
0.0030
2833
|
|
ENV
RAILIIIPRR
945
9
13
20
2834
|
|
ENV
ILHIPRRIR
947
9
13
20
2835
|
|
ENV
TVYYGVPVWK
48
10
41
64
3.8000
7.8000
2836
|
|
ENV
TTLFCASDAK
61
10
50
78
0.0920
0.2200
0.0019
0.0021
0.0570
2837
|
|
ENV
NVTENPNMWK
101
10
31
48
2838
|
|
ENV
IISLWDQSLK
121
10
38
59
0.0410
0.0540
0.0017
0.0020
0.0029
2839
|
|
ENV
TSAITQACPK
242
10
14
22
2840
|
|
ENV
TSVITQACPK
242
10
14
22
2841
|
|
ENV
CAPAGFAILK
264
10
29
45
2842
|
|
ENV
FAILKCNDKK
269
10
10
16
2843
|
|
ENV
STVQCTHGIK
289
10
28
44
2844
|
|
ENV
STVQCTHGIR
289
10
23
36
2845
|
|
ENV
SLAEEEVVIR
311
10
12
19
2846
|
|
ENV
CTRPNNNTRK
345
10
22
34
2847
|
|
ENV
ATGDIIGDIR
369
10
12
19
2848
|
|
ENV
EITTIISFNCR
430
10
11
17
2849
|
|
ENV
IINMWQEVGK
492
10
12
19
2850
|
|
ENV
GSENGTETFR
538
10
02
18
2851
|
|
ENV
PLGVAPTKAK
571
10
19
30
2852
|
|
ENV
GVAPTKAKRR
573
10
17
27
2853
|
|
ENV
VISTRTIIREK
584
10
01
50
2854
|
|
ENV
ISTRTIIREKR
585
10
01
50
2855
|
|
ENV
NIIITPIIREKR
586
10
01
50
2856
|
|
ENV
ASITLTVQAR
619
10
28
44
2857
|
|
ENV
IVQQQNNLLR
634
10
25
39
0.0024
0.0190
0.0130
0.0072
0.0035
2858
|
|
ENV
IVQQQSNLLR
634
10
26
41
2859
|
|
ENV
AIEAQQIILLK
644
10
12
19
2860
|
|
ENV
LLKLTVWGIK
651
10
13
20
2861
|
|
ENV
LLQLIVWGIK
651
10
34
53
0.0055
0.0110
2862
|
|
ENV
MLQLTVWGIK
651
10
10
16
2863
|
|
ENV
RVLAVERYLK
665
10
18
28
2864
|
|
ENV
RVLAVERYLR
665
10
10
16
2865
|
|
ENV
LLGIWGCSGK
678
10
50
78
0.1200
0.0120
0.0017
0.0020
0.0001
2866
|
|
ENV
MIVGGLICLR
782
10
36
56
2867
|
|
ENV
AVLSIVNRVR
795
10
31
48
2868
|
|
ENV
FLALAWDDLR
849
10
25
39
2869
|
|
ENV
RSLCLFSYIIR
858
10
31
48
2870
|
|
ENV
GLRLGWEGLK
892
10
10
32
2871
|
|
ENV
LLQYWSQELK
906
10
12
19
2872
|
|
ENV
AIAVAEGTDR
926
10
31
48
2873
|
|
ENV
AILIIIPRRIR
946
10
12
19
2874
|
|
ENV
PTRIRQGLER
951
10
12
19
2875
|
|
ENV
VTVYYGVPVWK
47
11
41
64
0.8600
4.1000
2876
|
|
ENV
KTTLFCASDAK
60
11
12
19
2877
|
|
ENV
TTTLFCASDAK
60
11
22
34
2878
|
|
ENV
DIISLWDQSLK
120
11
38
59
2879
|
|
ENV
NTSAITQACPK
241
11
14
22
2880
|
|
ENV
NISVITQACPK
241
11
13
20
2881
|
|
ENV
VSTVQCTHGIK
288
11
28
44
2882
|
|
ENV
VSTVQCTHGIR
288
11
23
36
2883
|
|
ENV
GSLAEEEVVIR
310
11
12
19
2884
|
|
ENV
YATGCIIGDIR
368
11
11
17
2885
|
|
ENV
KLREIRQFENK
405
11
01
25
2886
|
|
ENV
HTEGNITLQCR
478
11
01
50
2887
|
|
ENV
NANITIPCRIK
478
11
01
50
2888
|
|
ENV
QIINMWQEVGK
491
11
12
19
2889
|
|
ENV
SSNITGLLLTR
516
11
19
30
2890
|
|
ENV
NTETNKTETFR
537
11
01
17
2891
|
|
ENV
NTTGNTTETFR
537
11
01
17
2892
|
|
ENV
EIFRPGGGDMR
544
11
15
23
2893
|
|
ENV
ETFRPGGGDMR
544
11
20
31
2894
|
|
ENV
RSELYKYKVVK
558
11
29
45
2895
|
|
ENV
KIEPLGVAPTK
568
12
15
24
2896
|
|
ENV
PLGVAPTKAKR
571
11
19
30
2897
|
|
ENV
PTKAKRRVVQR
576
11
13
20
2898
|
|
ENV
KAKRRVVQREK
579
11
13
20
2899
|
|
ENV
IINIHTPIIREK
584
11
01
50
2900
|
|
ENV
VISTRTHREKR
584
11
01
50
2901
|
|
ENV
AASITLTVQAR
618
11
28
44
2902
|
|
ENV
GIVQQQNNLLR
633
11
25
39
2903
|
|
ENV
GIVQQQSNLLR
633
11
26
41
2904
|
|
ENV
HLLKLTVWGIK
650
11
13
20
2905
|
|
ENV
HLLQLTVWGIK
650
11
34
53
2906
|
|
ENV
TVWGIKQLQAR
655
11
48
75
2907
|
|
ENV
QLQARVLAVER
661
11
33
52
2908
|
|
ENV
QLLGIWGCSGK
677
11
50
78
2909
|
|
ENV
NVPWNSSWSNK
693
11
10
16
2910
|
|
ENV
LIEESQNQQEK
740
11
20
31
2911
|
|
ENV
IMIVGGLIGLR
781
11
34
54
2912
|
|
ENV
IIFAVLSIVNR
792
11
14
22
2913
|
|
ENV
IVFAVLSIVNR
792
11
17
27
2914
|
|
ENV
FAVLSIVNRVR
794
11
31
48
2915
|
|
ENV
GIEEEGGERDR
829
11
12
19
2916
|
|
ENV
NLCLFSYHRLR
859
11
11
17
2917
|
|
ENV
SLCLFSYIIRLR
859
11
31
48
2918
|
|
ENV
LLGRRGWEALK
882
11
09
IS
2919
|
|
ENV
NLLQYWSQELK
905
11
12
19
2920
|
|
ENV
IAIAVAEGTDR
925
11
10
16
2921
|
|
ENV
TAIAVAEGTDR
925
11
21
33
2922
|
|
ENV
RAILHIPRRIR
945
11
12
19
2923
|
|
GAG
GARASILR
2
8
10
16
2924
|
|
GAG
ASVLSGGK
5
8
29
45
2925
|
|
GAG
RLRPGGKK
20
8
49
77
2926
|
|
GAG
WASRELER
37
8
48
75
2927
|
|
GAG
QTGSEELR
71
8
12
19
2928
|
|
GAG
TLYCVHQK
86
8
12
19
2929
|
|
GAG
TLYCVHQR
86
8
I5
23
2930
|
|
GAG
RIEVKDTK
93
8
13
20
2931
|
|
GAC
DTKEALDK
98
8
36
56
0.0003
0.0001
2932
|
|
GAG
DTKEALEK
98
8
12
19
2933
|
|
GAG
KIEEEQNK
105
8
23
36
2934
|
|
GAG
PAAADKEK
123
8
01
50
2935
|
|
GAG
RTLNAWVK
171
8
63
98
0.0410
0.0560
2936
|
|
GAG
WVKVIEEK
176
8
29
45
2937
|
|
GAG
WVKVVEEK
176
8
31
48
0.0003
0.0001
2938
|
|
GAG
QAAMQMLK
216
8
61
95
2939
|
|
GAG
PIAPGQMR
243
8
19
30
2940
|
|
GAG
PIPPGQMR
243
8
17
27
2941
|
|
GAG
PVAPGQMR
243
8
10
16
2942
|
|
GAG
PVGDIYKR
281
8
18
28
2943
|
|
GAG
PVGEIYKR
281
8
40
63
0.0003
0.0001
2944
|
|
GAG
WIILGLNK
289
8
57
89
2945
|
|
GAG
PTSILDIR
303
8
12
19
2946
|
|
GAG
PVSILDIK
303
8
16
25
2947
|
|
GAG
PVSILDIR
303
8
25
39
2948
|
|
GAG
GVGGPGHK
376
8
37
58
0.0012
0.0018
2949
|
|
GAG
GVGGPSHK
376
8
23
36
2950
|
|
GAG
ASAQQDLK
392
8
01
50
2951
|
|
GAG
ATAQQDLK
392
8
01
50
2952
|
|
GAG
AAAIMMQK
400
8
04
19
2953
|
|
GAG
AAAIMMQK
405
8
01
25
2954
|
|
GAG
SATIMMQR
405
8
01
25
2955
|
|
GAG
YTAVFMQR
405
8
02
50
2956
|
|
GAG
MMQKSNFK
409
8
10
16
2957
|
|
GAG
MMQRGNFK
409
8
10
16
2958
|
|
GAG
MMQRGNPR
409
8
23
36
2959
|
|
GAG
QMKDCTER
455
8
49
77
2960
|
|
GAG
RASVLSGGK
4
9
29
45
2961
|
|
GAG
KLDAWEKIR
12
9
16
25
2962
|
|
GAG
KLDKWEKIR
12
9
10
16
2963
|
|
GAG
DAWEKIRLR
14
9
17
27
2964
|
|
GAG
KIRLRPGGK
18
9
44
69
2965
|
|
GAG
RLRPGGKKK
20
9
34
53
2966
|
|
GAG
LLETSEGCR
52
9
17
27
2967
|
|
GAG
ATLYCVIIQK
85
9
12
19
2968
|
|
GAG
ATLYCVIIQR
85
9
15
23
0.0150
0.7100
2969
|
|
GAG
MVHQAISPR
163
9
27
42
0.1800
0.0670
1.0000
2.1000
0.8400
2970
|
|
GAG
PIPYGEIYK
279
9
35
55
0.0002
0.0012
0.0006
0.0005
0.0003
2971
|
|
GAG
ILGLNKIVR
291
9
58
91
0.0008
0.0001
0.0032
0.0100
0.0004
2972
|
|
GAG
ILDIKQGPK
306
9
19
30
2973
|
|
GAG
ILDIRQGPK
306
9
42
66
0.0420
0.0048
0.0006
0.0006
0.0002
2974
|
|
GAG
NSATIMMQR
404
9
01
33
2975
|
|
GAG
IMMQKSNFK
408
9
10
16
2976
|
|
GAG
IMMQRGNFR
408
9
20
31
2977
|
|
GAG
IVKCFNCGK
422
9
13
20
2978
|
|
GAG
TIKCFNCGK
422
9
11
17
2979
|
|
GAG
TVKCFNCGK
422
9
11
17
2960
|
|
GAG
IAKNCRAPR
434
9
18
29
0.0009
0.0003
0.0330
0.0500
0.0039
2981
|
|
GAG
IARNCRAPR
434
9
13
21
2982
|
|
GAG
LARNCRAPR
434
9
20
32
2983
|
|
GAG
KIWPSHKGR
472
9
22
35
0.0770
0.0005
0.4400
0.0087
0.0001
2984
|
|
GAG
KIWPSNKGR
472
9
13
21
2985
|
|
GAG
KIWPSSKGR
472
9
10
16
2986
|
|
GAG
TAPPEESFR
496
9
15
23
2987
|
|
GAG
TAPPAESFR
508
9
02
67
2988
|
|
GAG
TAPPEESFR
508
9
01
33
2989
|
|
GAG
KIRLRPGGKK
18
10
44
69
1.9000
0.0010
0.0008
0.0005
0.0001
2990
|
|
GAG
KLKIIIVWASR
31
10
13
20
2991
|
|
GAG
RLKIILVWASR
31
10
17
27
2992
|
|
GAG
IVWASRELER
35
10
20
31
0.0099
0.0066
2993
|
|
GAG
LVWASRELER
35
10
26
41
2994
|
|
GAG
GLLETSEGCR
51
10
16
25
2995
|
|
GAG
VATLYCVIIQK
84
10
12
19
2996
|
|
GAG
VATLYCVIIQR
84
10
15
23
2997
|
|
GAG
KIEEEQNKSK
105
10
15
23
2998
|
|
GAG
QMVIIQAISPR
162
10
27
42
0.0260
0.0010
0.0740
0.1000
0.0430
2999
|
|
GAG
NAWVKVIEEK
174
10
29
45
3000
|
|
GAG
NAWVKVVEEK
174
10
30
47
0.0004
0.0002
3001
|
|
GAG
IAPGQMREPR
244
10
19
30
3002
|
|
GAG
PIPVGEIYKR
279
10
34
53
0.0003
0.0001
0.0009
0.0010
0.0005
3003
|
|
GAG
IILGLNKIVR
290
10
57
89
0.0003
0.0006
0.0110
0.0260
0.0073
3004
|
|
GAG
YSPTSILDIR
301
10
12
19
3005
|
|
GAG
YSPVSILDIK
301
10
16
25
3006
|
|
GAG
YSPVSILDIR
301
10
24
38
3007
|
|
GAG
SILDIKQGPK
305
10
18
28
3008
|
|
GAG
SILDIRQGPK
305
10
40
63
0.3100
0.7100
0.0017
0.0020
0.0060
3009
|
|
GAG
YVDRFFKILR
320
10
27
42
3010
|
|
GAG
YVDRIFYKTLR
320
10
28
44
0.0003
0.0006
3011
|
|
GAG
RAEQASQIWK
329
10
12
19
3112
|
|
GAG
RAEQATQDVK
329
10
15
23
3013
|
|
GAG
RAEQATQEVK
329
10
27
42
3014
|
|
GAG
LVQNANPDCK
346
10
59
92
0.0002
0.0110
3015
|
|
GAG
GVGGPGIIKAR
376
10
37
58
0.0003
0.0001
3016
|
|
GAG
GVGGPSIIKAR
376
10
22
34
3017
|
|
GAG
TIMMQRGNFR
407
10
12
21
3018
|
|
GAG
KTVKCFNCGK
421
10
08
16
3019
|
|
GAG
HIAKNCRAPR
433
10
18
28
3020
|
|
GAG
HIARNCRAPR
433
10
13
20
3021
|
|
GAG
HLARNCRAPR
433
10
20
31
3022
|
|
GAG
IAKNCRAPRK
434
10
16
25
3023
|
|
GAG
IARNCRAPRK
434
10
13
21
3024
|
|
GAG
LARNCRAPRK
434
10
20
32
3025
|
|
GAG
RAPRKKGCWK
439
10
51
80
3026
|
|
GAG
FLGKIWPSHK
469
10
23
36
0.0200
0.0013
3027
|
|
GAG
FLGKIWPSNK
469
10
13
20
3028
|
|
GAG
FLGKIWPSSK
469
10
10
16
3029
|
|
GAG
GTRPGNYVQK
480
10
01
50
3030
|
|
GAG
GTRPGNYVQR
480
10
01
50
3031
|
|
GAG
PTAPPEESFR
495
10
15
23
3032
|
|
GAG
PTAPPAESFR
507
10
02
67
3033
|
|
GAG
PTAPPPESFR
507
10
01
33
3034
|
|
GAG
ITSLPKQEQK
526
10
01
50
3035
|
|
GAG
PSQKQEPIDK
528
10
11
18
3036
|
|
GAG
GARASVLSGGK
2
11
29
46
3037
|
|
GAG
LSGGKLDAWEK
8
11
15
23
3038
|
|
GAG
KLDAWEKIRLR
12
11
16
25
3039
|
|
GAG
KLDKWEKIRLR
12
11
10
16
3040
|
|
GAG
KIRLRPGGKKK
18
11
30
47
3041
|
|
GAG
RLRPGGKKKYK
20
11
12
19
3042
|
|
GAG
RLRPGGKKKYR
20
11
19
30
3043
|
|
GAG
HIVWASRELER
34
11
20
31
3044
|
|
GAG
HLVWASRELER
34
11
26
41
3045
|
|
GAG
TVATLYCVIIQK
83
11
12
19
3046
|
|
GAG
TVATLYCVIIQR
83
11
14
22
3047
|
|
GAG
EVKDIKEALDK
95
11
13
20
3048
|
|
GAG
ALDKIEEEQNK
102
11
17
27
3049
|
|
GAG
KIEEEQNKSKK
105
11
15
23
3050
|
|
GAG
PAAADKEKDSK
123
11
01
50
3051
|
|
GAG
ISPRTLNAWVK
168
11
36
56
3052
|
|
GAG
LSPRTLNAWVK
168
11
17
27
3053
|
|
GAC
TINEEAAEWDR
225
11
53
83
3054
|
|
GAG
HAGPIAPGQMR
240
11
18
28
3055
|
|
GAG
IIAGPIPPGQMR
240
11
17
27
3056
|
|
GAG
PIAPGQMREPR
243
11
19
30
3057
|
|
GAG
PIPPGQMREPR
243
11
17
27
3058
|
|
GAG
WIILGLNKIVR
289
11
57
89
3059
|
|
GAG
TSILDIRQGPK
304
11
12
19
3060
|
|
GAG
VSILDIKQGPK
304
11
16
25
3061
|
|
GAG
VSILDIRQGPK
304
11
25
39
3062
|
|
GAG
DIKQGIKEPFR
308
11
19
30
3063
|
|
GAG
DIRQGPKEPFR
308
11
41
64
3064
|
|
GAG
LLVQNANPDCK
345
11
58
91
3065
|
|
GAG
NANPDCKTILK
349
11
27
42
3066
|
|
GAG
NANPDCKTILR
349
11
18
28
3067
|
|
GAG
AAIMMQKSNFK
406
11
06
15
3068
|
|
GAG
ATIMMQRGNFR
406
11
11
28
3069
|
|
GAG
MMQRGNFRNQR
409
11
15
23
3070
|
|
GAG
IIIAKNCRAPRK
433
11
16
25
3071
|
|
GAG
IIIARNCRAPRK
433
11
13
20
3072
|
|
GAG
IILARNCRAPRK
433
11
20
31
3073
|
|
GAG
IAKNCRAPRKK
434
11
14
22
3074
|
|
GAG
IARNCRAPRKK
434
11
13
21
3075
|
|
GAG
LARNCRAPRKK
434
11
19
30
3076
|
|
GAG
CTERQANFLGK
459
11
52
83
3077
|
|
GAG
EITSLPKQEQK
525
11
01
50
3078
|
|
NEF
AVSQDLDK
48
8
10
16
3079
|
|
NEF
AVSRDLEK
48
8
11
17
3080
|
|
NEF
PLRPMTFK
102
8
10
16
3081
|
|
NEF
PLRPMTYK
102
8
49
77
0.0010
0.0003
3082
|
|
NEF
LSFFLKEK
114
8
22
34
3083
|
|
NEF
LSHFLKEK
114
8
27
42
3084
|
|
NEF
GLIYSKKR
173
8
23
36
3085
|
|
NEF
YTPGPGIR
207
8
20
31
3086
|
|
NEF
YTPGPGTR
207
8
21
33
3087
|
|
NEF
YTPGPGVR
207
8
12
19
3088
|
|
NEF
LTFGWCFK
221
8
39
61
3089
|
|
NEF
KLVPVDPR
228
8
11
17
3090
|
|
NEF
ELHPEFYK
324
8
14
22
3091
|
|
NEF
ELHPEYYK
324
8
22
34
3092
|
|
NEF
GAVSQDLDK
47
9
10
16
3093
|
|
NEF
GAVSRDLEK
47
9
11
17
0.0002
0.0009
0.0004
0.0006
0.0001
3094
|
|
NEF
PVRPQVPLR
95
9
48
75
3095
|
|
NEF
AVDLSHFLK
111
9
14
22
0.0740
1.1000
0.0009
0.0008
0.0025
3096
|
|
NEF
DLSFFLKEK
113
9
22
34
3097
|
|
NEF
DLSIIFLKEK
113
9
27
42
3098
|
|
NEF
GLDGLIYSK
125
9
16
25
3099
|
|
NEF
GLEGLIYSK
125
9
10
16
3100
|
|
NEF
PLTFGWCFK
219
9
39
61
3101
|
|
NEF
AADGVGAVSR
42
10
09
15
3102
|
|
NEF
QVPLRPMTFK
100
10
10
16
3103
|
|
NEF
QVPLRPMTYK
100
10
46
72
0.6100
0.6300
0.0098
0.0130
0.0600
3104
|
|
NEF
GAFDLSFFLK
110
10
10
16
3105
|
|
NEF
GLDGLIYSKK
125
10
14
22
3106
|
|
NEF
GVGAVSQDLDK
45
11
10
16
3107
|
|
NEF
GVGAVSRDLEK
45
11
11
17
3108
|
|
NEF
AVDLSIIFLKEK
111
11
13
20
3109
|
|
NEF
GLDGLIYSKKR
125
11
14
22
3110
|
|
NEF
MARELIIPEYYK
321
11
10
16
3111
|
|
POL
RANSPTRR
26
8
16
25
3112
|
|
POL
RANSPTSR
26
8
17
27
3113
|
|
POL
STNSPTSR
32
8
01
33
3114
|
|
POL
RANSPSSR
35
8
01
33
3115
|
|
POL
RANSPTTR
37
8
01
50
3116
|
|
POL
ILIEICGK
149
11
14
22
3117
|
|
POL
LIEICGHK
150
8
10
16
3118
|
|
POL
LIEICGKK
150
8
14
22
3119
|
|
POL
PIETVPVK
190
8
53
83
3120
|
|
POL
ETVPVKLK
192
8
53
83
0.0049
0.0001
3121
|
|
POL
GMDGPKVK
201
8
51
80
0.0007
0.0004
3122
|
|
POL
PLTEEKIK
212
8
55
86
3123
|
|
POL
EICTEMEK
223
8
27
42
3124
|
|
POL
NTPIFAIK
246
8
24
38
3125
|
|
POL
NTPVFAIK
246
8
37
58
0.0003
0.0003
3126
|
|
POL
PIFAIKKK
248
8
25
39
3127
|
|
POL
PVFAIKKK
248
8
37
58
0.0003
0.0001
3128
|
|
POL
PAGLKKKK
286
8
52
81
3129
|
|
POL
PLDKDFRK
308
8
19
30
3130
|
|
POL
NVLPQGWK
336
8
63
100
0.0003
0.0012
3131
|
|
POL
KILEPFRK
355
8
23
36
3132
|
|
POL
DLEIGQIIR
381
8
52
81
3133
|
|
POL
EIGQIIRAK
383
8
27
42
3134
|
|
POL
EIGQIIRTK
383
8
22
34
3135
|
|
POL
RAKIEELR
388
8
26
41
3136
|
|
POL
RTKIEELR
388
8
22
34
3137
|
|
POL
ELREHLLK
393
8
17
27
3138
|
|
POL
ELRQHLLR
393
8
15
23
3139
|
|
POL
WTVNDIQK
441
8
62
97
0.0003
0.0001
3140
|
|
POL
DIQKLVGK
445
8
62
97
3141
|
|
POL
ELELAENR
489
8
53
83
3142
|
|
POL
GVYYDPSK
508
8
43
67
3143
|
|
POL
DLIAEIQK
516
8
28
44
3144
|
|
POL
QIYQEPFK
532
8
41
64
0.0010
0.0013
3145
|
|
POL
GAIITNDVK
551
8
19
30
3146
|
|
POL
SAIITNDVK
551
8
16
25
3147
|
|
POL
TAIITNDVK
551
8
11
17
3148
|
|
POL
QLTEAVQK
559
8
37
58
3149
|
|
POL
QLTEVVQK
559
8
11
17
3150
|
|
POL
ESIVIWGK
570
8
50
79
3151
|
|
POL
VIWGKTPK
573
8
48
75
3152
|
|
POL
KLWYQLEK
616
8
46
72
3153
|
|
POL
YVDGAANR
633
8
50
78
0.0003
0.0001
3154
|
|
POL
GAANRETK
636
8
45
70
3155
|
|
POL
KAGYVTDR
646
8
42
66
3156
|
|
POL
VTDRGRQK
650
8
40
63
0.0090
0.0065
3157
|
|
POL
LTDTTNQK
661
8
19
30
3158
|
|
POL
LTETTNQK
661
8
30
47
3159
|
|
POL
IIQAQPDK
697
8
40
63
3160
|
|
POL
IIQAQPDR
697
8
16
25
3161
|
|
POL
QIIEQLIK
712
8
37
58
3162
|
|
POL
IIEQLIKK
713
8
37
58
3163
|
|
POL
LAWVPAIIK
725
8
22
34
3164
|
|
POL
LSWVPAIIK
725
8
37
58
3165
|
|
POL
KLVSAGIR
742
8
16
25
3166
|
|
POL
KLVSSGIR
742
8
29
45
3167
|
|
POL
LVSAGIRK
743
8
16
25
0.0091
0.0054
3168
|
|
POL
LVSSGIRK
743
8
27
42
3169
|
|
POL
KAQEEIIEK
759
8
27
43
3170
|
|
POL
KAQEEIIER
759
8
16
25
3171
|
|
POL
NLPPIVAK
779
8
26
41
3172
|
|
POL
NLPPVVAK
779
8
27
42
3173
|
|
POL
EIVMICDK
787
8
45
70
3174
|
|
POL
ETAYFILK
848
8
31
48
3175
|
|
POL
ETAYFLLK
848
8
27
42
0.0037
0.0430
3176
|
|
POL
FILKLAGR
852
8
32
50
3177
|
|
POL
FLLKLAGR
852
8
25
39
3178
|
|
POL
LAGRWPVK
856
8
50
78
3179
|
|
POL
UVVESMNK
901
8
49
77
3180
|
|
POL
ESMNKELK
904
8
53
83
3181
|
|
POL
SMNKELKK
905
8
53
83
3182
|
|
POL
AVFIIINFK
931
8
62
97
0.0280
0.0380
3183
|
|
POL
FIIINFKRK
933
8
58
91
3184
|
|
POL
IASDIQTK
956
8
14
22
3185
|
|
POL
IATDIQTK
956
8
36
56
3186
|
|
POL
ELQKQIIK
964
8
13
21
3187
|
|
POL
ELQKQITK
964
8
35
56
3188
|
|
POL
IIKIQNFR
969
8
12
19
3189
|
|
POL
ITKIQNFR
969
8
36
57
3190
|
|
POL
RVYYRDSR
976
8
58
91
3191
|
|
POL
DSRDPIWK
981
8
35
55
3192
|
|
POL
DSRDILWK
981
8
14
22
3193
|
|
POL
PIWKGPAK
985
8
36
56
3194
|
|
POL
PLWKGPAK
985
8
19
30
3195
|
|
POL
DIKVVPRR
1009
8
48
75
3196
|
|
POL
EIKVVPRR
1009
8
16
25
3197
|
|
POL
VVPRRKAK
1012
8
52
81
0.0027
0.0001
3198
|
|
POL
VVPRRKVK
1012
8
11
17
3199
|
|
POL
KIIKDYGK
1019
8
11
17
3200
|
|
POL
KIIRDYGK
1019
8
50
78
3201
|
|
POL
LAFPQGEAR
6
9
12
19
3202
|
|
POL
LAFQQCEAR
6
9
16
25
3203
|
|
POL
QTRANSPTR
21
9
15
24
3204
|
|
POL
NSTNSPTSR
31
9
01
33
3205
|
|
POL
PTSRELQVR
36
9
01
33
3206
|
|
POL
PSSRELQVR
39
9
01
50
3207
|
|
POL
TIKIGGQLK
99
9
17
27
0.2700
0.0330
0.0010
0.0008
0.1100
3208
|
|
POL
DINLPGKWK
122
9
13
20
3209
|
|
POL
EINLPGKWK
122
9
12
19
3210
|
|
POL
NLPGKWKPK
124
9
36
56
3211
|
|
POL
GIGGFIKVK
136
9
11
17
3212
|
|
POL
GIGGFIKVR
136
9
53
83
0.0008
0.0005
0.0062
0.0120
0.0001
3213
|
|
POL
QILIEICGK
148
9
14
22
3214
|
|
POL
ILIEICGKK
149
9
14
22
3215
|
|
POL
PTPVNIIGR
166
9
54
84
0.0008
0.0001
0.0007
0.0120
0.0002
3216
|
|
POL
CTEMEKEGK
225
9
28
44
0.0002
0.0001
0.0006
0.0006
0.0002
3217
|
|
POL
NTPIFAIKK
246
9
24
38
3218
|
|
POL
NTPVFAIKK
246
9
37
58
00330
0.0600
0.0006
0.0006
1.7000
3219
|
|
POL
AIKKKDSTK
251
9
57
89
0.0017
0.0086
0.0018
0.0005
0.0001
3220
|
|
POL
LVDFRELNK
263
9
62
97
0.0110
0.0300
0.0006
0.0006
0.0002
3221
|
|
POL
GIPHPAGLK
282
9
56
89
0.2300
0.0650
0.0007
0.0005
0.0110
3222
|
|
POL
SVPLDKDFR
306
9
18
28
3223
|
|
POL
AIFQSSMTK
347
9
36
56
0.1000
0.9600
0.0076
0.0005
0.0230
3224
|
|
POL
MTKILEPFR
353
9
43
67
0.0008
0.0160
0.2200
0.4200
0.3100
3225
|
|
POL
TTPDKKHQK
404
9
57
89
0.0002
0.0042
0.0021
0.0029
0.0053
3226
|
|
POL
ASQIYAGIK
456
9
27
43
0.0013
0.3400
0.0005
0.0018
0.0001
3227
|
|
POL
ASQIYPGIK
456
9
28
44
3228
|
|
POL
QIYAGIKVK
458
9
20
32
3229
|
|
POL
QIYPGIKVK
458
9
12
19
3230
|
|
POL
QIYPGIKVR
458
9
14
22
3231
|
|
POL
GIKVKQLCK
462
9
28
44
3232
|
|
POL
GIKVRQLCK
462
9
19
30
3233
|
|
POL
LAENREILK
492
9
54
84
0.0002
0.0003
0.0004
0.0006
0.0001
3234
|
|
POL
NLKTGKYAK
540
9
28
44
3235
|
|
POL
NLKTGKYAR
540
9
29
46
0.0008
0.0001
0.0130
0.4400
0.0033
3236
|
|
POL
KTGKYAKMR
542
9
19
30
3237
|
|
POL
KTGKYARMR
542
9
13
21
3238
|
|
POL
RSAHTNDVK
550
9
10
16
3239
|
|
POL
IVIWGKTPK
572
9
48
75
0.0850
0.3700
0.9900
0.3000
0.0330
3240
|
|
POL
FVNTPPLVK
608
9
54
86
0.0020
0.0660
0.0009
0.0099
0.0380
3241
|
|
POL
YVTDRGRQK
649
9
39
61
0.0011
0.0010
0.0006
0.0006
0.0039
3242
|
|
POL
SLTDITNQK
660
9
11
17
3243
|
|
POL
SLTETTNQK
660
9
21
33
3244
|
|
POL
GIIQAQPDK
696
9
40
63
0.0009
0.0400
0.0006
0.0005
0.0003
3245
|
|
POL
GIIQAQPDR
696
9
16
25
3246
|
|
POL
QIIEQLIKK
712
9
37
58
0.0091
0.1600
0.0006
0.0005
0.0120
3247
|
|
POL
YLAWVPAIIK
724
9
22
34
0.0770
0.0570
0.0550
0.8800
4.0000
3248
|
|
POL
YLSWVPAIIK
724
9
37
58
3249
|
|
POL
KLVSAGIRK
742
9
16
25
0.1300
0.0770
0.0017
0.0020
0.0001
3250
|
|
POL
KLVSSGIRK
742
9
27
42
3251
|
|
POL
VLFLDGIDK
751
9
51
80
0.0380
0.0320
0.0006
0.0006
0.0004
3252
|
|
POL
ASCDKCQLK
790
9
43
67
0.0027
0.0140
0.0020
0.0009
0.0001
3253
|
|
POL
KLAGRWPVK
855
9
50
78
2.7000
0.0690
0.2100
0.0006
0.0002
3254
|
|
POL
AACWWAGIK
880
9
21
33
0.0130
0.0470
0.0023
0.0041
0.0014
3255
|
|
POL
ESMNKELKK
904
9
53
83
3256
|
|
POL
MAVFIIINFK
930
9
60
94
0.0170
0.3000
0.0480
0.0560
3.2000
3257
|
|
POL
AVFIIINFKR
931
9
62
97
0.1700
1.8000
3.5000
0.2700
1.9000
3258
|
|
POL
IIASDIQTK
955
9
14
22
3259
|
|
POL
IIATDIQTK
955
9
35
55
0.0250
0.0980
0.0007
0.0005
0.0002
3260
|
|
POL
DIQIKELQK
959
9
46
72
0.0009
0.0006
0.0006
0.0018
0.0001
3261
|
|
POL
QIIKIQNFR
968
9
12
19
3262
|
|
POL
QITKIQNFR
968
9
35
55
0.0021
0.0045
0.2400
0.0660
0.2600
3263
|
|
POL
VIQDNSDIK
1003
9
37
58
0.0009
0.0068
0.0006
0.0005
0.0001
3264
|
|
POL
VIQDNSEIK
1003
9
12
19
3265
|
|
POL
NSDIKVVPR
1007
9
40
63
3266
|
|
POL
NSEIKVVPR
1007
9
12
19
3267
|
|
POL
DIKVVPRRK
1009
9
48
75
0.0002
0.0001
0.0006
0.0069
0.0065
3268
|
|
POL
EIKVVPRRK
1009
9
15
23
3269
|
|
POL
KVVPRRKAK
1010
9
52
81
0.0290
0.0039
0.3100
0.0008
0.0002
3270
|
|
POL
KVVPRRKVK
1011
9
11
17
3271
|
|
POL
NLAFPQGEAR
5
10
10
16
3272
|
|
POL
NLAFQQGEAR
5
10
16
25
3273
|
|
POL
QTRANSPTRR
21
10
11
18
3274
|
|
POL
QTRANSPTSR
21
10
12
19
3275
|
|
POL
PSRANSPTSR
24
10
01
50
3276
|
|
POL
QTRANSPSSR
33
10
01
33
3277
|
|
POL
QTRANSPTTR
35
10
01
33
3278
|
|
POL
VTIKIGGQLK
98
10
17
27
0.0370
0.2100
0.0017
0.0025
0.0640
3279
|
|
POL
VLEDINLPGK
119
10
13
20
3280
|
|
POL
VLEEINLPGK
119
10
12
19
3281
|
|
POL
MIGGIGGFIK
133
10
62
97
0.0099
0.0550
0.0052
0.0012
0.3100
3282
|
|
POL
QILIEICGKK
148
10
14
22
3283
|
|
POL
ISPIETVPVK
188
10
53
83
0.0003
0.0310
0.0017
0.0025
0.0001
3284
|
|
POL
PIETVPVKLK
190
10
53
83
0.0002
0.0001
0.0009
0.0009
0.0003
3285
|
|
POL
KLKPGMDGPK
197
10
49
77
0.3900
0.0760
3286
|
|
POL
LVEICTEMEK
221
10
15
24
0.0002
0.0120
0.0001
0.0013
0.0024
3287
|
|
POL
EMEKEGKISK
229
10
33
52
0.0004
0.0001
0.0009
0.0009
0.0003
3288
|
|
POL
NTPIFAIKKK
246
10
24
38
3289
|
|
POL
NTPVFAIKKK
246
10
37
58
0.0006
0.0046
3290
|
|
POL
FAIKKKDSTK
250
10
57
89
0.0004
0.0002
3291
|
|
POL
KLVDFRELNK
262
10
62
97
0.5100
0.0900
3292
|
|
POL
LVDFRELNKR
263
10
60
94
3293
|
|
POL
GIPHPAGLKK
282
10
54
86
0.0110
0.1700
0.0009
0.0009
0.0007
3294
|
|
POL
DAYFSVPLDK
302
10
21
33
3295
|
|
POL
FSVPLDKDFR
305
10
18
28
3296
|
|
POL
SVPLDKIWRK
306
10
8
28
3297
|
|
POL
SINNETPGIR
323
10
32
50
3298
|
|
POL
STNNETPGIR
323
10
11
17
3299
|
|
POL
PAIFQSSMTK
346
10
36
56
0.0760
0.0830
0.0017
0.0025
0.0046
3300
|
|
POL
SMTKILEPFR
352
10
42
66
0.0004
0.0004
3301
|
|
POL
MTKILEPFRK
353
10
22
34
0.0150
0.0380
0.0150
0.0060
0.1100
3302
|
|
POL
GSDLEIGQHR
379
10
52
81
3303
|
|
POL
DLEIGQIIRAK
381
10
27
42
3304
|
|
POL
DLEIGQIIRTK
381
10
21
33
3305
|
|
POL
FTTPDKKIIQK
403
10
51
80
0.0002
0.0150
0.0010
0.0013
0.0273
3306
|
|
POL
WMGYELIIPDK
418
10
60
94
0.0005
0.0004
0.0009
0.0006
0.0003
3307
|
|
POL
TVQPIQLPEK
429
10
17
27
3308
|
|
POL
TVQPIVLPEK
429
10
13
20
0.1600
5.6000
3309
|
|
POL
DSWTVNDIQK
439
10
43
67
0.0007
0.002
3310
|
|
POL
ESWTVNDIQK
439
10
11
17
3311
|
|
POL
WASQIVAGIK
455
10
27
42
3312
|
|
POL
WASQIYPGIK
455
10
28
44
3313
|
|
POL
KVKQLCKLLR
464
10
27
42
3314
|
|
POL
KVRQLCKLLR
464
10
19
30
3315
|
|
POL
QLCKLLRGAK
467
10
25
39
3316
|
|
POL
QLCKLLRGTK
467
10
21
33
3317
|
|
POL
EAELELAENR
487
10
53
83
3318
|
|
POL
ELAENREILK
491
10
54
84
0.0002
0.0003
3319
|
|
POL
ATESIVIWGK
568
10
19
30
3320
|
|
POL
SIVIWGKTPK
571
10
42
66
3321
|
|
POL
VIWGKTPKFK
573
10
17
27
3322
|
|
POL
VIWGKTPKFR
573
10
29
45
3323
|
|
POL
LVKLWYQLEK
614
10
46
72
0.0560
0.0820
0.0075
0.0081
0.0097
3324
|
|
POL
AANRETKLGK
637
10
30
47
0.0007
0.0016
3325
|
|
POL
KAGYVIDRGR
646
10
39
61
3326
|
|
POL
VSLTDTTNQK
659
10
10
16
3327
|
|
POL
VSLTETTNQK
659
10
20
31
3328
|
|
POL
VSQIIEQLIK
710
10
19
30
0.0007
0.0370
0.0017
0.0025
0.0007
3329
|
|
POL
IIEQLIKKEK
713
10
30
47
0.0004
0.0003
0.0009
0.0008
0.0003
3330
|
|
POL
GIGGNEQVDK
733
10
58
91
0.0005
0.0001
0.0009
0.0009
0.0003
3331
|
|
POL
KVLFLDGIDK
750
10
48
75
0.3600
0.7800
3332
|
|
POL
VASCDKCQLK
789
10
43
67
0.0004
0.0004
3333
|
|
POL
QLDCTHLEGK
814
10
60
95
0.0010
0.0003
3334
|
|
POL
GSNFTSAAVK
870
10
26
41
3335
|
|
POL
GSNFTSTTVK
870
10
11
17
3336
|
|
POL
KAACWWAGIK
879
10
20
32
0.0300
0.0740
0.0017
0.00250
0.0002
3337
|
|
POL
VVESMNKELK
902
10
48
75
3338
|
|
POL
ELKKIIGQVR
909
10
56
88
3339
|
|
POL
QVRDQAEHLK
916
10
44
69
0.0089
0.0093
3340
|
|
POL
QVREQAEHLK
916
10
13
20
3341
|
|
POL
QMAVFIHNFK
929
10
60
94
0.6100
0.6400
0.0240
0.0083
0.0610
3342
|
|
POL
MAVFIHNFKR
930
10
60
94
0.0068
0.0083
3343
|
|
POL
AVFIHNFKRK
931
10
58
91
0.6600
0.8500
3344
|
|
POL
GIGGYSAGER
942
10
58
91
0.0003
0.0001
0.00010
0.0029
0.0003
3345
|
|
POL
DIIASDIQTK
954
10
14
22
3346
|
|
POL
DIIATDIQTK
954
10
34
53
0.0056
0.0130
0.0017
0.0025
0.0170
3347
|
|
POL
KIQNFRVYYR
971
10
52
81
0.0320
0.2100
6.6000
0.0850
0.0380
3348
|
|
POL
VVIQDNSDIK
1002
10
37
58
0.0005
0.0210
0.0010
0.0013
0.0018
3349
|
|
POL
VVIQDNSEIK
1002
10
12
19
3350
|
|
POL
NSDIKVVPRR
1007
10
40
63
0.0007
0.0001
3351
|
|
POL
NSEIKVVPRR
1007
10
12
19
3352
|
|
POL
KAKIIRDYGK
1017
10
41
64
0.0048
0.0018
3353
|
|
POL
MAGDDCVAGR
1028
10
24
38
3354
|
|
POL
MAGDLICVASR
1028
10
19
30
3355
|
|
POL
NSPTSRELQVR
34
11
01
33
3356
|
|
POL
NSPSSRELQVR
37
11
01
50
3357
|
|
POL
NSPTTRELQVR
39
11
01
50
3358
|
|
POL
FSFPQITLWQR
85
11
14
22
3359
|
|
POL
TLWQRPLVTIK
91
11
17
27
3360
|
|
POL
TLWQRPLVTVK
91
11
13
20
3361
|
|
POL
LVTIKIGGQLK
97
11
13
20
3362
|
|
POL
TVLEDINLPGK
118
11
13
20
3363
|
|
POL
TVLEEINLPGK
118
11
12
19
3364
|
|
POL
DINLPGKWKPK
122
11
13
20
3365
|
|
POL
EINLPGKWKPK
122
11
12
19
3166
|
|
POL
KMIGGIGGFIK
132
11
62
97
2.3000
0.7000
3367
|
|
POL
PISPIETVPVK
187
11
53
83
3368
|
|
POL
KVKQWPLTEEK
207
11
46
72
0.0750
0.0330
3369
|
|
POL
ALVEICTEMEK
220
11
15
23
3370
|
|
POL
EICTEMEKEGK
223
11
27
42
3371
|
|
POL
AIKKKDSTKWR
251
11
57
89
3372
|
|
POL
STKWRKLVDFR
257
11
58
91
3373
|
|
POL
KLVDFRELNKR
262
11
60
94
3374
|
|
POL
QLGIPIIPAGLK
280
11
56
89
3375
|
|
POL
GIPIIPAGLKKK
282
11
53
84
3376
|
|
POL
FSVPLDKDFRK
305
11
18
28
3377
|
|
POL
PSINNETPGIR
322
11
31
48
3378
|
|
POL
PSTNNETPGIR
322
11
11
17
3379
|
|
POL
SSMTKILEPFR
351
11
32
50
3380
|
|
POL
SMTKILEPFRK
352
11
22
34
3381
|
|
POL
KIEELREIILLK
390
11
13
20
3382
|
|
POL
KIEELRQIILLR
390
11
15
23
3383
|
|
POL
LLKWGFTTPDK
398
11
23
36
3384
|
|
POL
LLRWGFTTPDK
398
11
23
36
3385
|
|
POL
WTVQPIQLPEK
428
11
17
27
3386
|
|
POL
WTVQPIVLPEK
428
11
13
20
0.0011
0.0510
3387
|
|
POL
TVNDIQKLVGK
442
11
61
95
0.0400
0.1700
3388
|
|
POL
ASQIYAGIKVK
456
11
20
32
3389
|
|
POL
ASQIYPGIKVK
456
11
12
19
3390
|
|
POL
ASQIYPGIKVR
456
11
14
22
3391
|
|
POL
YAGIKVKQLCK
460
11
18
28
3392
|
|
POL
PVIIGVYYDPSK
505
11
39
61
3393
|
|
POL
PSKDLIAEIQK
513
11
25
39
3394
|
|
POL
WTYQIYQEPFK
529
11
40
63
0.9200
0.0540
3395
|
|
POL
QIYQEPPKNLK
532
11
40
63
0.2800
0.2900
3396
|
|
POL
NLKTGKYAKMR
540
11
15
29
3397
|
|
POL
NLKTGKYARMR
540
11
13
21
3398
|
|
POL
RMRGAHTNDVK
548
11
12
19
3399
|
|
POL
DVKQLTEAVQK
556
11
33
52
0.0048
0.0240
3400
|
|
POL
IATESIVIWGK
567
11
14
22
3401
|
|
POL
ESIVIWGKTPK
570
11
41
65
3402
|
|
POL
IVIWGKTPKFK
572
11
17
27
3403
|
|
POL
IVIWGKTPKFR
572
11
29
45
3404
|
|
POL
KTPKFKLPIQK
577
11
14
22
3405
|
|
POL
KTPKFRLPIQK
577
11
22
34
3406
|
|
POL
PLVKLWYQLEK
613
11
45
70
3407
|
|
POL
ETFYVDGAANR
630
11
43
67
3408
|
|
POL
YVDGAANRETK
633
11
44
69
3409
|
|
POL
GAANRETKLGK
636
11
30
47
3410
|
|
POL
KLGKAGYVTDR
643
11
24
38
3411
|
|
POL
VVSLTDTINQK
658
11
10
16
3412
|
|
POL
VVSLTEKTTNQK
658
11
11
17
3413
|
|
POL
ALGIIQAQPDK
694
11
39
61
3414
|
|
POL
ALGIIQAQPDR
694
11
15
23
3415
|
|
POL
LVNQIIEQLIK
709
11
15
23
3416
|
|
POL
LVSQIIEQLIK
709
11
15
28
3417
|
|
POL
VSQIIEQLIKK
710
11
19
30
3418
|
|
POL
QIIEQIIKKEK
712
11
30
47
3419
|
|
POL
KVYLAWVPAIIK
722
11
20
32
8.6000
2.3000
3420
|
|
POL
KVYLSWVPAIIK
722
11
23
37
3421
|
|
POL
QVDKLVSAGIR
739
11
15
23
3422
|
|
POL
QVDKLVSSGIR
739
11
29
45
3423
|
|
POL
GIDKAQEEHEK
756
11
25
39
3424
|
|
POL
GIDKAQEEHER
756
11
14
22
3425
|
|
POL
VAKEIVASCDK
784
11
45
71
3426
|
|
POL
IVASCDKCQLK
788
11
43
67
0.0970
0.1000
3427
|
|
POL
TAYFILKLAGR
849
11
31
48
3428
|
|
POL
TAYFLLKLAGR
849
11
24
38
3429
|
|
POL
ILKLAGRWPVK
853
11
30
47
3430
|
|
POL
LLKLAGRWPVK
853
11
20
31
3431
|
|
POL
QSQGVVESMNK
898
11
49
77
3432
|
|
POL
GVVESMNKELK
901
11
48
75
3433
|
|
POL
VVESMNKELKK
902
11
48
75
3434
|
|
POL
QMAVFIIINFKR
929
11
60
94
3435
|
|
POL
MAVFIIINFKRK
930
11
57
89
3436
|
|
POL
ASDIQTKELQK
957
11
11
17
3437
|
|
POL
ATDIQTKELQK
957
11
35
55
0.0051
0.1800
3438
|
|
POL
QTKELQKQIIK
961
11
10
16
3439
|
|
POL
QTKELQKQITK
961
11
32
50
0.0050
0.0100
3440
|
|
POL
AVVIQDNSDIK
1000
11
37
58
0.0004
0.0150
3441
|
|
POL
AVVIQDNSEIK
1000
11
12
19
3442
|
|
POL
NSDIKVVPRRK
1007
11
40
63
3443
|
|
POL
NSEIKVVPRRK
1007
11
11
17
3444
|
|
POL
DIKVVFRRKAK
1009
11
39
61
3445
|
|
POL
EIKVVPRRKAK
1009
11
13
20
3446
|
|
POL
VVPRRKAKIIR
1012
11
42
66
3447
|
|
POL
QMAGDDCVAGR
1027
11
24
38
3448
|
|
POL
QMAGDDCVASR
1027
11
19
30
3449
|
|
REV
DSDEELLK
7
8
12
19
3450
|
|
REV
QARKNRRR
40
8
17
27
3451
|
|
REV
QARRNRRR
40
8
38
59
3452
|
|
REV
RARQRQIR
50
8
12
19
3453
|
|
REV
ILSTCLGR
63
8
12
19
3454
|
|
REV
GTETGVGR
103
8
06
19
3455
|
|
REV
LLKTVRLIK
12
9
10
16
3456
|
|
REV
GTRQARKNR
36
9
15
23
3457
|
|
REV
GTRQARRNR
36
9
34
53
3458
|
|
REV
GTRQTRKNR
37
9
01
50
3459
|
|
REV
TTRQARRNR
37
9
01
50
3460
|
|
REV
QARKNRRRR
40
9
16
25
3461
|
|
REV
QARRNRRRR
40
9
38
59
3462
|
|
REV
RILSTCLGR
62
9
12
19
3463
|
|
REV
PLQLPPIER
76
9
11
17
3464
|
|
REV
PLQLPPLER
76
9
35
55
3465
|
|
REV
PSPEGTRQAR
31
10
13
20
3466
|
|
REV
GTRQARKNRR
36
10
15
23
3467
|
|
REV
GTRQARRNRR
36
10
34
53
3468
|
|
REV
TTRQARTNRR
37
10
01
50
3469
|
|
REV
TTRQARRNRR
37
10
01
50
3470
|
|
REV
RSGDSDEELLK
4
11
11
17
3471
|
|
REV
PSPEGTRQARR
31
11
13
20
3472
|
|
REV
GTRQARRNRRR
36
11
14
22
3473
|
|
REV
GTRQARRNRRR
36
11
34
53
3474
|
|
REV
GTRQTRKNRRR
37
11
01
50
3475
|
|
REV
TTRQARRNRRR
37
11
01
50
3476
|
|
REV
QARKNRRRRWR
40
11
16
25
3477
|
|
REV
QARRNRRRRWR
40
11
37
58
3478
|
|
REV
PVPLQLPPIER
74
11
11
17
3479
|
|
REV
PVPLQLPPLER
74
11
34
53
3480
|
|
TAT
GLGISYGR
45
8
55
87
3410
|
|
TAT
GISYGRKK
47
8
58
91
3482
|
|
TAT
ISYGRKKR
48
8
58
91
3483
|
|
TAT
PTGPKESK
88
8
20
31
3484
|
|
TAT
TACNNCYCK
23
9
17
27
3485
|
|
TAT
TACTNCYCK
23
9
10
16
3486
|
|
TAT
GLGISYGRK
45
9
55
87
0.0340
0.0006
0.0017
0.0020
0.0001
3487
|
|
TAT
GISYGRKKR
47
9
57
89
0.0008
0.0005
0.0018
0.0014
0.0001
3488
|
|
TAT
ISYGRKKRR
48
9
46
72
0.0008
0.0005
0.3900
0.1300
0.0032
3489
|
|
TAT
PTGPKESKK
88
9
18
28
3490
|
|
TAT
ESKKKVESK
93
9
12
19
3491
|
|
TAT
PVDPRLEPWK
3
10
11
17
0.0008
0.0001
3492
|
|
TAT
TACNNCYCKK
23
10
11
17
3493
|
|
TAT
GLGISYGRKK
45
10
55
87
3494
|
|
TAT
GISYGRKKRR
47
10
45
70
0.0003
0.0001
3495
|
|
TAT
PTGPKESKKK
88
10
12
19
3496
|
|
TAT
KAGPGGYPRR
101
10
01
50
3497
|
|
TAT
GLGISYGRKKR
45
11
54
86
3498
|
|
TAT
ISYGRKKRRQR
48
11
39
61
3499
|
|
TAT
KAGPGGYPRRK
101
11
01
50
3500
|
|
VIP
LIVWQVDR
8
8
10
16
3501
|
|
VIP
MIVWQVDR
8
8
46
72
3502
|
|
VIP
QVDRMKIR
12
8
13
20
3503
|
|
VIP
QVDRMRIR
12
8
34
53
3504
|
|
VIP
RMRINTWK
15
8
10
16
3505
|
|
VIP
RMRIRTWK
15
8
15
23
3506
|
|
VIP
RTWKSLVK
19
8
15
23
3507
|
|
VIP
RTWNSLVK
19
8
27
42
3508
|
|
VIP
HIPLGDAR
56
8
13
20
3509
|
|
VIP
HIPLGEAR
56
8
20
31
3510
|
|
VIP
GVSIEWRK
87
8
16
25
3511
|
|
VIP
VSIEWRLR
88
8
15
23
3512
|
|
VIP
SIEWRLRP
89
8
11
17
3513
|
|
VIP
FSDSAIRK
120
8
13
20
3514
|
|
VIP
FSESAIRK
120
8
14
22
3515
|
|
VIP
SLQYLALK
149
8
13
20
3516
|
|
VIP
LALTALIK
153
8
16
25
3517
|
|
VIP
LTALIKPK
155
8
13
20
3518
|
|
VIP
TALIKPKK
156
8
11
17
3519
|
|
VIP
LIKPKKIK
158
8
10
16
3520
|
|
VIP
LTEDRWNK
178
8
31
48
0.0003
0.0045
3521
|
|
VIP
LVEDRWNK
178
8
11
17
3522
|
|
VIP
VMIVWQVDR
7
9
44
69
0.0034
0.0220
4.8000
5.5000
0.0010
3523
|
|
VIP
IVWQVDRMK
9
9
12
19
3524
|
|
VIP
IVWQVDRMR
9
9
47
73
0.0008
0.0007
0.4500
0.5600
0.0048
3525
|
|
VIP
GVSIEWRLR
87
9
14
22
3526
|
|
VIP
VSIEWRLRR
88
9
11
17
3527
|
|
VIP
GSLQYLALK
148
9
13
20
3528
|
|
VIP
YLALTALIK
152
9
16
25
3529
|
|
VIP
ALTALIKPK
154
9
13
20
3530
|
|
VIP
LTALIKPKK
155
9
11
17
3531
|
|
VIP
ALIKPKKIK
157
9
10
16
3532
|
|
VIP
SVKKLTEDR
174
9
13
20
3533
|
|
VIP
KLTEERWNK
177
9
29
45
0.0130
0.2700
0.0680
0.0006
0.0002
3534
|
|
VIP
KLVEDRWNK
177
9
11
17
3535
|
|
VIP
QVMIVWQVDR
6
10
43
67
3536
|
|
VIP
MIVWQVDRMR
8
10
43
67
0.0062
0.0001
3537
|
|
VIP
KIRTWNSLVK
17
10
12
19
3538
|
|
VIP
RIRTWKSLVK
17
10
15
23
3539
|
|
VIP
RIRTWNSLVK
17
10
15
23
3540
|
|
VIP
LVKHHMYVSK
24
10
12
19
3541
|
|
VIP
EVHIPLGDAR
54
10
13
20
3542
|
|
VIP
EVHIPLGEAR
54
10
20
31
3543
|
|
VIP
GVSIEWRLRR
87
10
10
16
3544
|
|
VIP
LALTALIKPK
153
10
13
20
3545
|
|
VIP
ALTALIKPKK
154
10
33
17
3546
|
|
VIP
PSVKKLTEDR
173
10
13
20
3547
|
|
VIP
VMIVWQVDRMR
7
11
41
64
3548
|
|
VIP
IVWQVDRMKIR
9
11
12
19
3549
|
|
VIP
IVWQVDRMRIR
9
11
33
52
3550
|
|
VIP
QVDRMRINTWK
12
33
10
16
3551
|
|
VIP
QVDRMRIRTWK
12
11
14
22
3552
|
|
VIP
SLVKHHMYVSK
23
11
12
19
3553
|
|
VIP
LVKHHMYVSKK
24
11
12
19
3554
|
|
VIP
TTYWGLHTGER
69
11
22
34
3555
|
|
VIP
HLGHGVSIEWR
83
11
22
34
3556
|
|
VIP
HLGQGVSIEWR
83
11
25
39
3557
|
|
VIP
YLALTALIKPK
152
11
13
20
3558
|
|
VIP
LALTALIKPKK
153
11
11
17
3559
|
|
VIP
LTEDRWNKPQK
178
33
21
33
0.0390
0.0130
3560
|
|
VIP
LVEDRWNKPQK
178
11
10
16
3561
|
|
VPR
ELKNEAVR
25
8
17
27
3562
|
|
VPR
ELKSEAVR
25
8
16
25
3563
|
|
VPR
EAVRIIFPR
29
8
59
92
3564
|
|
VPR
QLLFIIIPR
66
8
44
69
3565
|
|
VPR
QLLFVIIFR
66
8
10
16
3566
|
|
VPR
RIGCQIISR
74
8
47
73
3567
|
|
VPR
RIGCRIISR
74
8
12
19
3568
|
|
VPR
IISRIGIIR
79
8
10
16
3569
|
|
VPR
IISRIGITR
79
8
33
17
3570
|
|
VPR
RIGITRQR
81
8
30
16
3571
|
|
VPR
#LPGRRGR
85
8
03
50
3572
|
|
VPR
NIRGRRVR
85
8
03
50
3573
|
|
VPR
RARNGASR
93
8
39
30
3574
|
|
VPR
ALELLEELK
39
9
30
16
3575
|
|
VPR
TLELLEELK
39
9
44
69
3576
|
|
VPR
WAGVEAIIR
54
9
16
25
3577
|
|
VPR
FIHFRIGCR
69
9
11
37
3578
|
|
VPR
RIGITRQRR
83
9
30
36
3579
|
|
VPR
QAPEDQGPQR
3
30
39
62
3580
|
|
VPR
WALELLEELK
18
10
09
35
3581
|
|
VPR
WTLELLEELK
18
10
42
69
3582
|
|
VPR
KSEAVRHPPR
27
30
34
22
3583
|
|
VPR
HSRIGITRQR
79
30
30
36
3584
|
|
VPR
LLEELKNEAVR
22
33
37
27
3585
|
|
VPR
LLEELKSEAVR
22
33
36
25
3586
|
|
VPR
DTWAGVEAIIR
52
33
36
25
3587
|
|
VPR
DTWEGVEAIIR
52
33
38
28
3588
|
|
VPR
ILQQLLFIHPR
63
11
35
55
3589
|
|
VPR
LLFIHFRIGCR
67
33
11
37
3590
|
|
VPR
HSRIGITRQRR
79
11
30
36
3591
|
|
VPU
TIVFIEYR
35
8
10
36
3592
|
|
VPU
IYFIEYRK
36
8
32
39
3593
|
|
VPU
LVQRKQDR
43
8
03
50
3594
|
|
VPU
KIDRLIDR
52
8
15
23
3595
|
|
VPU
LIDRIRER
58
8
14
22
3596
|
|
VPU
VTLLSSSK
94
8
01
50
3597
|
|
VPU
WTIVFIEYR
34
9
10
16
3598
|
|
VPU
LVQRKQDRR
43
9
01
50
3599
|
|
VPU
ILRQRKIDR
46
9
15
23
3600
|
|
VPU
RLIDRIRER
56
9
10
16
3601
|
|
VPU
LVTLLSSSK
91
9
01
50
3602
|
|
VPU
KILRQRKIDR
45
10
15
23
0.0039
0.0001
3603
|
|
VPU
KIDRLIDRIR
52
30
30
36
3604
|
|
VPU
VVWTIVFIEYR
31
11
30
16
3605
|
|
TABLE X
|
|
|
HIV A24 Super Motif Peptides with Binding Information
|
No. of
Sequence
Conservancy
|
Protein
Sequence
Position
Aminio Acids
Frequency
(%)
A*2401
SEQ ID NO
|
|
ENV
LILGLVII
21
8
09
15
3606
|
|
ENV
KLWVTVYY
44
8
11
17
3607
|
|
ENV
NLWVTVYY
44
8
35
56
3608
|
|
ENV
VYYGVPVW
49
8
55
86
3609
|
|
ENV
DTEVHNVW
75
8
19
30
3610
|
|
ENV
NVTENFNM
101
8
34
53
3611
|
|
ENV
VTENFNMW
102
8
34
53
3612
|
|
ENV
SLKPCVKL
128
8
55
86
3613
|
|
ENV
LTPLCVTL
135
8
54
84
3614
|
|
ENV
HYCAPAGF
262
8
27
42
3615
|
|
ENV
HYCTPAGF
262
8
11
17
3616
|
|
ENV
CTPAGFAI
264
8
10
16
3617
|
|
ENV
TVQCTHGI
290
8
51
80
3618
|
|
ENV
PVVSTQLL
300
8
60
94
3619
|
|
ENV
VVSTQLLL
301
8
60
94
3620
|
|
ENV
QLLLNGSL
305
8
57
89
3621
|
|
ENV
NTRKSIRI
351
8
10
16
3622
|
|
ENV
RIGPCQTF
357
8
11
17
3623
|
|
ENV
GIGPGQTF
360
8
01
33
3624
|
|
ENV
SIGSGQAF
360
8
01
33
3625
|
|
ENV
FYATGDII
367
8
12
19
3626
|
|
ENV
KLREIRQI
405
8
01
25
3627
|
|
ENV
SFNCGGEF
437
8
36
56
3628
|
|
ENV
SFNCRGLF
437
8
16
25
3629
|
|
ENV
FYCNTSGL
445
8
21
33
3630
|
|
ENV
IITEGNITL
478
8
01
50
3631
|
|
ENV
NITLPCRI
482
8
11
17
3632
|
|
ENV
TITLPCRI
482
8
14
22
3633
|
|
ENV
RIKQIINM
488
8
30
47
3634
|
|
ENV
RIKQIVNM
488
8
12
19
3635
|
|
ENV
QIRCSSNI
512
8
11
17
3636
|
|
ENV
STNGTETF
537
8
01
17
3637
|
|
ENV
KVVKIEPL
565
8
25
39
3638
|
|
ENV
AVGIGAVF
595
8
11
17
3639
|
|
ENV
STMGAASI
614
8
39
61
3640
|
|
ENV
LTVQARQL
623
8
38
59
3641
|
|
ENV
TVQARQLL
624
8
36
56
3642
|
|
ENV
IVQQQNNL
634
8
26
41
3643
|
|
ENV
IVQQQSNL
634
8
32
50
3644
|
|
ENV
AIEAQQHL
644
8
49
77
3645
|
|
ENV
HLLKLTVW
650
8
13
20
3646
|
|
ENV
HLLQLTVW
650
8
34
53
3647
|
|
ENV
HMLQLTVW
650
8
10
16
3648
|
|
ENV
TVWGIKQL
655
8
59
92
3649
|
|
ENV
RVLAVERY
665
8
33
52
3650
|
|
ENV
VLAVERYL
666
8
34
53
3651
|
|
ENV
RYLKDQQL
671
8
30
47
3652
|
|
ENV
RYLRDQQL
671
8
18
28
3653
|
|
ENV
YLKDQQLL
672
8
31
48
0.0001
3654
|
|
ENV
YLRDQQLL
672
8
18
28
3655
|
|
ENV
IWGCSGKL
681
8
48
75
3656
|
|
ENV
NVPWNSSW
693
8
13
20
3657
|
|
ENV
EIWDNMTW
716
8
13
20
3658
|
|
ENV
IWDNMTWM
717
8
11
17
3659
|
|
ENV
IWNNMTWM
717
8
17
27
3660
|
|
ENV
WMEWEREI
723
8
12
19
3661
|
|
ENV
DLLALDKW
754
8
21
33
3662
|
|
ENV
ELLELDKW
754
8
20
31
3663
|
|
ENV
ALDKWASL
757
8
11
17
3664
|
|
ENV
ELDKWASL
757
8
18
28
3665
|
|
ENV
KWASLWNW
760
8
26
41
3666
|
|
ENV
SLWNWFDI
763
8
17
27
3667
|
|
ENV
WFDITNWL
767
8
10
16
3668
|
|
ENV
DITNWLWY
769
8
10
16
3669
|
|
ENV
ITKWLWYI
770
8
16
25
3670
|
|
ENV
ITNWLWYI
770
8
19
30
3671
|
|
ENV
KWLWYIKI
772
8
19
30
3672
|
|
ENV
NWLWYIKI
772
8
25
39
3673
|
|
ENV
WLWYIKIF
773
8
50
78
3674
|
|
ENV
LWYIKIFI
774
8
49
77
3675
|
|
ENV
WYIKIFIM
775
8
43
67
3676
|
|
ENV
VIKIFIMI
776
8
43
67
3677
|
|
ENV
FIMIVGGL
780
8
44
69
3678
|
|
ENV
IMIYGGLI
781
8
35
56
3679
|
|
ENV
IYGGLIGL
783
8
42
66
3680
|
|
ENV
IVGGLVGL
783
8
10
16
3681
|
|
ENV
GLIGLRII
786
8
51
23
3682
|
|
ENV
LIGLRIIF
787
8
16
25
3683
|
|
ENV
LIGLRIVF
787
8
29
45
3684
|
|
ENV
IIFAVLSI
792
8
15
23
3685
|
|
ENV
IYFAYLSI
792
8
20
31
3686
|
|
ENV
PLSFQTLL
809
8
10
16
3687
|
|
ENV
SIRLVNGF
842
8
13
20
3688
|
|
ENV
SIRLVSGF
842
8
13
20
3689
|
|
ENV
LVNGFLAL
845
8
14
22
3690
|
|
ENV
LYSGFLAL
845
8
19
30
3691
|
|
ENV
AWDDLRSL
853
8
20
31
3692
|
|
ENV
DLRNLCLF
856
8
17
27
3693
|
|
ENV
DLRSLCLF
856
8
38
59
3694
|
|
ENV
CLFSYHRL
861
8
42
66
3695
|
|
ENV
SYIIRLRDF
864
8
18
28
3696
|
|
ENV
SYHRLRDL
864
8
23
36
3697
|
|
ENV
RLRDLLLI
867
8
13
20
3698
|
|
ENV
ELLGHSSL
881
8
09
15
3699
|
|
ENV
ELLGRRGW
881
8
23
37
3700
|
|
ENV
GWEALKYL
896
8
12
19
3701
|
|
ENV
GWEGLKYL
896
8
12
19
3702
|
|
ENV
YWWNLLQY
902
8
15
23
3703
|
|
ENV
WWNLLQYW
903
8
15
23
3704
|
|
ENV
SLLNATAI
920
8
14
22
3705
|
|
ENV
ILIIIPRRI
947
8
13
20
3706
|
|
ENV
PTRIRQGL
951
8
12
19
3707
|
|
ENV
TVYYGVPVW
48
9
55
86
3708
|
|
ENV
VWKEATTTL
55
9
22
34
0.0300
3709
|
|
ENV
PTDPNPQEI
89
9
25
39
3710
|
|
ENV
NVTENFNMW
101
9
34
53
3711
|
|
ENV
NFNMWKNDM
105
9
12
19
3712
|
|
ENV
NFNMWKNNM
105
9
18
28
3713
|
|
ENV
MVEQMIIEDI
113
9
23
36
3714
|
|
ENV
QMIIEDIISL
116
9
29
45
3715
|
|
ENV
IISLWDQSL
121
9
38
59
3716
|
|
ENV
VISLWDQSL
121
9
10
16
3717
|
|
ENV
KLTPLCVTL
134
9
52
81
3718
|
|
ENV
EIKNCSFNI
181
9
13
20
3719
|
|
ENV
LINCNTSAI
237
9
15
23
3720
|
|
ENV
KVSFEPIPI
252
9
30
47
3721
|
|
ENV
SFEPIPIIIY
254
9
31
48
3722
|
|
ENV
ILKCNDKKF
271
9
12
19
3723
|
|
ENV
STVQCTIIGI
289
9
51
80
3724
|
|
ENV
PVVSTQLLL
300
9
60
94
3725
|
|
ENV
SLAEEEVVI
311
9
13
20
3726
|
|
ENV
RIGPGQTFY
357
9
11
17
3727
|
|
ENV
GIGPGQTFY
360
9
01
33
3728
|
|
ENV
SIGSGQAFY
360
9
01
33
3729
|
|
ENV
ATGDIIGDI
369
9
12
19
3730
|
|
ENV
DIRQAIICNI
380
9
15
23
3731
|
|
ENV
DLEITTIISF
428
9
21
33
3732
|
|
ENV
SFNCGGEFF
437
9
35
55
3733
|
|
ENV
SFNCRGEFF
437
9
16
25
3734
|
|
ENV
FFYCNTSGL
444
9
21
33
3735
|
|
ENV
FYCNTSGLF
445
9
21
33
3736
|
|
ENV
TLPCRIKQI
484
9
26
41
3737
|
|
ENV
RIKQIINMW
488
9
30
47
3738
|
|
ENV
RIKQIVNMW
488
9
12
19
3739
|
|
ENV
MWQEVGKAM
495
9
15
23
3740
|
|
ENV
MWQRVGQAM
495
9
10
16
3741
|
|
ENV
IFRPGGGDM
545
9
17
27
3742
|
|
ENV
TFRPGGGDM
545
9
25
39
3743
|
|
ENV
NWRSELYKY
556
9
54
84
3744
|
|
ENV
LYKYKVVEI
561
9
13
20
3745
|
|
ENV
LYKYKVVKI
561
9
29
45
0.0200
3746
|
|
ENV
AVGIGAVFL
595
9
11
17
3747
|
|
ENV
GIGAVFLGF
598
9
11
18
3748
|
|
ENV
MLGAMFLGF
599
9
04
36
3749
|
|
ENV
TIGAMFLGF
S99
9
03
27
3750
|
|
ENV
FLGAAGSTM
608
9
55
86
3751
|
|
ENV
TMGAASITL
615
9
39
61
3752
|
|
ENV
TLTVQARQL
622
9
37
58
3753
|
|
ENV
LTVQARQLL
623
9
36
56
3754
|
|
ENV
GIVQQQNNL
633
9
26
41
3755
|
|
ENV
GIVQQQSNL
633
9
32
50
3756
|
|
ENV
IVQQQNNLL
634
9
26
41
3757
|
|
ENV
IVQQQSNLL
634
9
32
50
3758
|
|
ENV
AIEAQQNLL
644
9
48
75
3759
|
|
ENV
LLKLTVWGI
651
9
13
20
3760
|
|
ENV
LLQLTVWGI
651
9
34
53
3761
|
|
ENV
MLQLTVWGI
651
9
10
16
3762
|
|
ENV
LTVWGIKQL
654
9
59
92
3763
|
|
ENV
RYLAVERYL
665
9
33
52
3764
|
|
ENV
RYLKDQQLL
671
9
29
45
0.7600
3765
|
|
ENV
RYLRDQQLL
671
9
17
27
0.2300
3766
|
|
ENV
GIWGCSGKL
680
9
48
75
3767
|
|
ENV
IWGCSGKLI
681
9
48
75
0.0270
3768
|
|
ENV
LICTTAVPW
688
9
19
30
3769
|
|
ENV
LICTTNVPW
688
9
17
27
3770
|
|
ENV
LICTTTVPW
688
9
12
19
3771
|
|
ENV
IWMEWEREI
722
9
12
19
3772
|
|
ENV
EWEREIDNY
725
9
11
17
3773
|
|
ENV
ALDKWASLW
757
9
11
17
3774
|
|
ENV
ELDKWASLW
757
9
18
28
3775
|
|
ENV
KWASLWNWF
760
9
26
41
3776
|
|
ENV
WFDITNWLW
767
9
10
16
3777
|
|
ENV
DITNWLWYI
769
9
10
16
3778
|
|
ENV
KWLWYIKIP
772
9
16
25
3779
|
|
ENV
NWLWYIKIF
772
9
25
39
3780
|
|
ENV
WLWYIKIFI
773
9
49
77
3781
|
|
ENV
LWYIKIFIM
774
9
43
67
3782
|
|
ENV
WYIKIFIMI
775
9
43
67
3783
|
|
ENV
IFIMIVGGL
779
9
41
64
3784
|
|
ENV
FIMIVGGLI
780
9
35
55
3785
|
|
ENV
MIVGGLIGL
782
9
36
56
3786
|
|
ENV
GLIGLRIIF
786
9
15
23
3787
|
|
ENV
GLIGLRIVF
786
9
29
45
3788
|
|
ENV
GLRIIFAVL
789
9
17
27
3789
|
|
ENV
GLRIVFAVL
789
9
28
44
3790
|
|
ENV
RIIFAYLSI
791
9
14
22
3791
|
|
ENV
RIVFAVLSI
791
9
19
30
3792
|
|
ENV
IVNRVRQGY
799
9
38
59
3793
|
|
ENV
RVRQGYSPL
802
9
55
86
3794
|
|
ENV
SIRLVNGFL
842
9
11
17
3795
|
|
ENV
SIRLVSGFL
842
9
13
20
3796
|
|
ENV
RLVNGFLAL
844
9
12
19
3797
|
|
ENV
RLVSGFLAL
844
9
19
30
3798
|
|
ENV
FLALAWDDL
849
9
25
39
3799
|
|
ENV
SYHRLRDFI
864
9
13
20
3800
|
|
ENV
SYHRLRDLL
864
9
14
22
3801
|
|
ENV
LIAARTVEL
873
9
12
19
3802
|
|
ENV
SLKGLRLGW
889
9
11
39
3803
|
|
ENV
SLRGLQRGW
889
9
05
18
3804
|
|
ENV
GLRLGWEGL
892
9
10
32
3805
|
|
ENV
RLGWEGLKY
894
9
09
29
3806
|
|
ENV
KYWWNLLQY
901
9
14
22
3807
|
|
ENV
YWWNLLQYW
902
9
15
23
3808
|
|
ENV
LLQYWSQEL
906
9
16
25
3809
|
|
ENV
ELKNSAINL
913
9
10
16
3810
|
|
ENV
ELKNSAISL
913
9
10
16
3811
|
|
ENV
ELKNSAVSL
913
9
12
19
3812
|
|
ENV
AVAEGTDRI
928
9
16
25
3813
|
|
ENV
AILHIPRRI
946
9
12
19
3814
|
|
ENV
VTVYYGVPVW
47
10
55
86
3815
|
|
ENV
PVWKEATTTL
54
10
22
34
3816
|
|
ENV
VWKEATTTLF
55
10
22
34
0.2700
3817
|
|
ENV
LFCASDAKAY
65
10
42
66
3818
|
|
ENV
AYDTEVHNVW
73
10
18
28
3819
|
|
ENV
MWKNNMVEQ
108
10
35
55
3820
|
|
ENV
NMVEQMIIEDI
112
10
20
31
0.0004
3821
|
|
ENV
MVEQMIIEDII
113
10
23
36
3822
|
|
ENV
QMIIEDIISLW
116
10
29
45
3823
|
|
ENV
DIISLWDQSL
120
10
38
59
3824
|
|
ENV
DVISLWDQSL
120
10
10
16
3825
|
|
ENV
RLINCNISAI
236
10
15
24
3826
|
|
ENV
ITQACPKVSF
245
10
29
45
3827
|
|
ENV
PIHYCAPAGF
260
10
27
42
3828
|
|
ENV
PIIIYCTPAGF
260
10
10
16
3829
|
|
ENV
IIYCAPAGFAI
262
10
27
42
3830
|
|
ENV
IIYCTPAGFAI
262
10
10
16
3831
|
|
ENV
AILKCNDKKF
270
10
12
19
3832
|
|
ENV
GIKPVVSTQL
297
10
33
52
3833
|
|
ENV
GIRPVVSIQL
297
10
26
41
3834
|
|
ENV
STQLLLNGSL
303
10
57
89
3835
|
|
ENV
NTSPRSRVAY
376
10
01
33
3836
|
|
ENV
SFNCGGEFFY
437
10
35
55
3837
|
|
ENV
SFNCRGEFFY
437
10
16
25
3838
|
|
ENV
EFFYCNTSGL
443
10
21
33
3839
|
|
ENV
FFYCNTSGLF
444
10
21
33
3840
|
|
ENV
ITLPCRIKQI
483
10
25
39
3841
|
|
ENV
TLPCRIKQII
484
10
15
23
3842
|
|
ENV
NMWQEVGKA
494
10
15
23
0.0001
3843
|
|
ENV
MWQEVGKAM
495
10
15
23
3844
|
|
ENV
MWQRVGQAM
495
10
10
16
3845
|
|
ENV
NTETNKTETF
537
10
01
17
3846
|
|
ENV
NTTGNTTETF
537
10
01
17
3847
|
|
ENV
EIFRPGGGDM
544
10
17
27
3848
|
|
ENV
ETFRPGGGDM
544
10
21
33
3849
|
|
ENV
DMRDNWRSEL
552
10
37
38
3850
|
|
ENV
ELYKYKYVEI
560
10
13
21
3851
|
|
ENV
ELYKYKVVKI
560
10
29
46
3852
|
|
ENV
KYKVVKIEPL
563
10
25
39
3853
|
|
ENV
GIGAVFLGFL
598
10
11
18
3854
|
|
ENV
MLGAMFLGFL
599
10
04
36
3855
|
|
ENV
TIGAMFLGFL
599
10
03
27
3856
|
|
ENV
GFLGAAGSTM
606
10
55
86
3857
|
|
ENV
STMGAASITL
614
10
39
61
3858
|
|
ENV
ITLTVQARQL
621
10
27
42
3859
|
|
ENV
TLTVQARQLL
622
10
35
55
3860
|
|
ENV
GIVQQQNNLL
633
10
26
41
3861
|
|
ENV
GIVQQQSNLL
633
10
32
50
3862
|
|
ENV
HLLKLTVWGI
650
10
13
20
3863
|
|
ENV
HLLQLTVWGI
650
10
34
53
3864
|
|
ENV
KLTVWGIKQL
653
10
13
20
3865
|
|
ENV
QLTVWGIKQL
653
10
44
69
3866
|
|
ENV
GIKQLQARVL
658
10
40
63
3867
|
|
ENV
YLKDQQLLGI
672
10
27
42
3868
|
|
ENV
YLRDQQLLGI
672
10
18
28
3869
|
|
ENV
GIWGCSGKLI
680
10
48
75
3870
|
|
ENV
KLICTTAVPW
687
10
19
30
3871
|
|
ENV
KLICTTNVPW
687
10
17
27
3872
|
|
ENV
KLICTTTVPW
687
10
12
19
3873
|
|
ENV
TTNVPWNSS
691
10
11
17
3874
|
|
ENV
IWNNMTWME
717
10
10
16
3875
|
|
ENV
MTWMEWERE
721
10
12
19
3876
|
|
ENV
LLALDKWASL
755
10
11
17
3877
|
|
ENV
LLELDKWASL
755
10
18
28
3878
|
|
ENV
WFDITNWLW
767
10
10
16
3879
|
|
ENV
ITKWLWYIKI
770
10
15
23
3880
|
|
ENV
ITNWLWYIKI
770
10
14
22
3881
|
|
ENV
KWLWYIKIFI
772
10
16
25
3882
|
|
ENV
NWLWYIKIFI
772
10
25
39
3883
|
|
ENV
WLWYIKIFIM
773
10
43
67
3884
|
|
ENV
LWYIKIFIMI
774
10
43
67
3885
|
|
ENV
KIFIMIVGGL
778
10
38
59
3886
|
|
ENV
IFIMIVGGLI
779
10
33
52
3887
|
|
ENV
IMIVGGLIGL
781
10
34
54
3888
|
|
ENV
IVGGLIGLRI
783
10
42
66
3889
|
|
ENV
SIVNRVRQGY
798
10
36
56
3890
|
|
ENV
GYSPLSFQTL
806
10
29
45
3891
|
|
ENV
LVSGFLALAW
845
10
16
25
3892
|
|
ENV
GFLALAWDDL
848
10
25
39
3893
|
|
ENV
ALAWDDLRSL
851
10
19
30
3894
|
|
ENV
AWDDLRSLCL
853
10
20
31
3895
|
|
ENV
DLRNLCLFSY
856
10
16
25
3896
|
|
ENV
DLRSLCLFSY
856
10
35
55
3897
|
|
ENV
NLCLFSYHRL
859
10
11
17
3898
|
|
ENV
SLCLFSYHRL
859
10
31
48
3899
|
|
ENV
LFSYHRLRDP
862
10
18
28
3900
|
|
ENV
LFSYHRLRDL
862
10
22
34
3901
|
|
ENV
SYHRLRDFIL
864
10
13
20
3902
|
|
ENV
SYHRLRDLLL
864
10
12
19
3903
|
|
ENV
LIAARTVELL
873
10
11
17
3904
|
|
ENV
IVELLGRRGW
879
10
22
34
3905
|
|
ENV
LLGRRGWEAL
882
10
09
15
3906
|
|
ENV
RLGWEGLKYL
894
10
09
29
3907
|
|
ENV
KYWWNLLQY
901
10
14
22
3908
|
|
ENV
NLLQYWSQEL
905
10
16
25
3909
|
|
ENV
ELKNSAVSLL
913
10
10
16
3910
|
|
ENV
AVSLLNATAI
918
10
11
17
3911
|
|
ENV
AVAEGIDRII
928
10
15
23
3912
|
|
ENV
AVAEGTDRVI
928
10
14
22
3913
|
|
ENV
IIIPRRIRQGL
949
10
13
21
3914
|
|
ENV
NIPRRIRQGL
949
10
11
17
3915
|
|
ENV
RIRQGLERAL
953
10
34
53
3916
|
|
ENV
WVTVYYGVPV
46
11
55
86
3917
|
|
ENV
PVWKEATTTL
54
11
22
34
3918
|
|
ENV
TLFCASDAKA
64
11
40
63
3919
|
|
ENV
CVPTDPNPQEI
87
11
25
39
3920
|
|
ENV
PTDPNPQEVVL
89
11
12
19
3921
|
|
ENV
NMWKNNMVE
107
11
30
47
3922
|
|
ENV
NMVEQMIIEDII
112
11
20
31
3923
|
|
ENV
SLKPCVKLTPL
128
11
54
84
3924
|
|
ENV
CVKLTPLCVT
132
11
52
81
3925
|
|
ENV
VITQACPKVSF
244
11
14
22
3926
|
|
ENV
KYSFEPIPIIIY
252
11
28
44
3927
|
|
ENV
IIYCAPAGFAIL
262
11
27
42
3928
|
|
ENV
NVSTVQCTHGI
287
11
51
80
3929
|
|
ENV
GIKPVVSTQLL
297
11
33
52
3930
|
|
ENV
GIRPVVSTQLL
297
11
26
41
3931
|
|
ENV
PYATGDIIGDI
367
11
11
17
3932
|
|
ENV
GTAGNSSRAA
375
11
01
33
3933
|
|
ENV
TTIISFNCGGE
432
11
16
25
3934
|
|
ENV
TTIISFNCRGE
432
11
12
19
3935
|
|
ENV
VMIISFNCGGE
432
11
13
20
3936
|
|
ENV
EFFYCNTSGLF
443
11
21
33
3937
|
|
ENV
NITLPCRIKQI
482
11
11
17
3938
|
|
ENV
TITLPCRIKQI
482
11
13
20
3939
|
|
ENV
ITLPCRIKQII
483
11
15
23
3940
|
|
ENV
NMWQEVGKA
494
11
15
23
3941
|
|
ENV
EVGKAMYAPPI
498
11
18
28
3942
|
|
ENV
RVGQAMYAPP
498
11
10
16
3943
|
|
ENV
QIRCSSNITGL
512
11
11
17
3944
|
|
ENV
DMRDNWRSEL
552
11
37
58
3945
|
|
ENV
VVEREKRAVGI
588
11
11
17
3946
|
|
ENV
AVGIGAVFLGF
595
11
11
17
3947
|
|
ENV
SITLTVQARQL
620
11
27
42
3948
|
|
ENV
ITLTVQARQLL
621
11
27
42
3949
|
|
ENV
TVQARQLLSGI
624
11
36
56
3950
|
|
ENV
LLRAIEAQQHL
641
11
45
70
3951
|
|
ENV
AIEAQQHLLKL
644
11
12
19
3952
|
|
ENV
AIEAQQHLLQL
644
11
35
55
3953
|
|
ENV
AVERYLKDQQ
668
11
23
36
3954
|
|
ENV
AVERYLRDQQ
668
11
11
17
3955
|
|
ENV
RYLKDQQLLGI
671
11
25
39
3956
|
|
ENV
RYLRDQQLLGI
671
11
17
27
3957
|
|
ENV
YLKDQQLLGI
672
11
27
42
3958
|
|
ENV
YLRDQQLLGI
672
11
18
28
3959
|
|
ENV
LLGIWGCSGKL
678
11
46
72
3960
|
|
ENV
CTTNVPWNSS
690
11
11
17
3961
|
|
ENV
NMTWMEWER
720
11
12
19
3962
|
|
ENV
WMEWEREIDN
723
11
10
16
3963
|
|
ENV
ELLELDKWAS
754
11
15
23
3964
|
|
ENV
LLALDKWASL
755
11
11
17
3965
|
|
ENV
LLELDKWASL
755
11
18
28
3966
|
|
ENV
ALDKWASLW
757
11
10
16
3967
|
|
ENV
ELDKWASLWN
757
11
16
25
3968
|
|
ENV
KWASLWNWF
760
11
15
23
3969
|
|
ENV
WFDITNWLW
767
11
15
16
3970
|
|
ENV
ITKWLWVIKIF
770
11
12
19
3971
|
|
ENV
ITNWLWYIKIF
770
11
14
22
3972
|
|
ENV
KWLWYIKIFIM
772
11
15
23
3973
|
|
ENV
NWLWVIKIFIM
772
11
22
34
3974
|
|
ENV
WLWYIKIFIMI
773
11
43
67
3975
|
|
ENV
KIFIMIVGGLI
778
11
31
48
3976
|
|
ENV
FIMIVGGLIGL
780
11
34
53
3977
|
|
ENV
MIVGGLIGLRI
782
11
36
56
3978
|
|
ENV
IVGGLIGLRII
783
11
12
19
3979
|
|
ENV
LIGLRIIFAVL
787
11
15
23
3980
|
|
ENV
LIGLRIVFAVL
787
11
20
31
3981
|
|
ENV
GLRIIFAVLSI
789
11
14
22
3982
|
|
ENV
GLRIVFAVLSI
789
11
19
30
3983
|
|
ENV
RVRQGYSPLSF
802
11
47
73
3984
|
|
ENV
SIRLVSGFLAL
842
11
11
17
3985
|
|
ENV
RLVSGFLALA
844
11
16
25
3986
|
|
ENV
AWDDLRSLCL
853
11
20
31
3987
|
|
ENV
CLFSYIIRLRDF
861
11
18
28
3988
|
|
ENV
CLFSYIIRLRDL
861
11
20
31
3989
|
|
ENV
LFSYIIRLRDFI
862
11
13
20
3990
|
|
ENV
LFSYIIRLRDLL
862
11
13
20
3991
|
|
ENV
SYIIRLRDLLLI
864
11
10
16
3992
|
|
ENV
RIVELLGRRG
878
11
22
34
3993
|
|
ENV
ELLGRRGWEA
881
11
09
15
3994
|
|
ENV
GLRLGWEGLK
892
11
09
29
3995
|
|
ENV
RLGWEGLKYL
894
11
07
23
3996
|
|
ENV
YWGQELKNSA
909
11
12
19
3997
|
|
ENV
AIAVAEGTDRI
926
11
16
25
3998
|
|
ENV
RIRQGLERALL
953
11
33
52
3999
|
|
GAG
SVLSGGEL
6
8
11
17
4000
|
|
GAG
SVLSGGKL
6
8
28
44
4001
|
|
GAG
KLDAWEKI
12
8
I11
28
4002
|
|
GAG
KLDKWEKI
12
8
10
16
4003
|
|
GAG
IVWASREL
35
8
21
33
4004
|
|
GAG
LVWASREL
35
8
36
S6
4005
|
|
GAG
RFALNPGL
45
8
20
31
4006
|
|
GAG
RFAVNPGL
45
8
16
25
4007
|
|
GAG
GTEELRSL
73
8
12
19
4008
|
|
GAG
LFNTVATL
80
8
16
25
4009
|
|
GAG
LYNTVATL
80
8
22
34
4010
|
|
GAG
LYCVIIQKI
87
8
13
20
4011
|
|
GAG
LYCVIIQRI
87
8
18
28
4012
|
|
GAG
KVSQNYPI
148
8
15
27
4013
|
|
GAG
QVSQNYPI
148
8
27
48
4014
|
|
GAG
NYPIVQNL
152
8
31
48
4015
|
|
GAG
KVIEEKAF
178
8
24
38
4016
|
|
GAG
KVVIEEKAP
178
8
28
44
4017
|
|
GAG
VIPMFSAL
189
8
46
72
4018
|
|
GAG
VIPMFTAL
189
8
14
22
4019
|
|
GAG
ATPQDLNM
200
8
12
19
4020
|
|
GAG
DLNMMLNI
204
8
12
19
4021
|
|
GAG
TLQEQIAW
263
8
12
19
4022
|
|
GAG
TLQEQIGW
263
8
27
42
4023
|
|
GAG
WMTNNPPI
270
8
20
31
4024
|
|
GAG
WMISNPPI
270
8
16
25
4025
|
|
GAG
PIPVGDIY
279
8
11
17
4026
|
|
GAG
PIPVGEIY
279
8
35
55
4027
|
|
GAG
DIYKRWII
284
8
17
27
4028
|
|
GAG
EIYKRWII
284
8
39
61
4029
|
|
GAG
IYKRWIIL
285
8
54
84
4030
|
|
GAG
IILGLNKI
290
8
57
89
4031
|
|
GAG
GLNKIVRM
293
8
60
94
4032
|
|
GAG
RMYSPTSI
299
8
14
22
4033
|
|
GAG
RMYSPVSI
299
8
40
63
4034
|
|
GAG
MYSPTSIL
300
8
14
22
4035
|
|
GAG
MYSPVSIL
300
8
42
66
4036
|
|
GAG
ATQDVKNW
333
8
15
23
4037
|
|
GAG
ATQEVKNW
333
8
18
28
4038
|
|
GAG
NWMTDTLL
339
8
16
25
4039
|
|
GAG
NWMTETLL
339
8
36
56
4040
|
|
GAG
ALGPAATL
360
8
16
25
4041
|
|
GAG
ALGPGATL
360
8
18
28
4042
|
|
GAG
IMMQKSNF
408
8
11
17
4043
|
|
GAG
IMMQRGNF
408
8
27
42
4044
|
|
GAG
CTERQANP
459
8
55
87
4045
|
|
GAG
ETIDKDLY
537
8
01
25
4046
|
|
GAG
ELYPLASL
543
8
14
22
4047
|
|
GAG
ELYPLTSL
543
8
11
17
4048
|
|
GAG
PLASLKSL
548
8
15
23
4049
|
|
GAG
PLTSLKSL
548
8
12
19
4050
|
|
GAG
PLISLRSL
548
8
12
19
4051
|
|
GAG
LTSLKSLF
S49
8
13
20
4052
|
|
GAG
LTSLRSLF
549
8
12
19
4053
|
|
GAG
SLFGNDPL
554
8
12
19
4054
|
|
GAG
SLFGSDPL
554
8
11
17
4055
|
|
GAG
KYKLKIIIVW
29
9
10
16
4056
|
|
GAG
KYRLKIILVW
29
9
16
25
4057
|
|
GAG
IIIVWASREL
34
9
21
33
4058
|
|
GAG
IILVWASREL
34
9
36
56
4059
|
|
GAG
RFALNPGLL
45
9
20
31
4060
|
|
GAG
RFAVNPGLL
45
9
16
25
0.0100
4061
|
|
GAG
ETSEGCRQI
54
9
16
25
4062
|
|
GAG
ILGQLQPSL
62
9
11
17
4063
|
|
GAG
SLQTGSEEL
69
9
14
22
4064
|
|
GAG
SLFNTVATL
79
9
16
25
4065
|
|
GAG
SLYNTVATL
79
9
22
34
4066
|
|
GAG
LFNTVATLY
80
9
15
23
4067
|
|
GAG
LYNTYATLY
80
9
22
34
4068
|
|
GAG
TLYCVIIQKI
86
9
12
19
4069
|
|
GAG
TLYCVIIQRI
86
9
15
23
4070
|
|
GAG
DVKIYIKEAL
95
9
11
17
4071
|
|
GAG
EVKDTKEAL
95
9
20
31
4072
|
|
GAG
DTKEALDKI
98
9
32
50
4073
|
|
GAG
DIKEALEKI
98
9
10
16
4074
|
|
GAG
IVQNAQGQM
155
9
21
33
4075
|
|
GAG
IVQNLQGQM
155
9
29
45
4076
|
|
GAG
TLNAWVKVI
172
9
30
47
4077
|
|
GAG
AFSPEVIPM
184
9
50
78
4078
|
|
GAG
EVIPMFSAL
188
9
46
72
4079
|
|
GAG
EVIPMFTAL
188
9
14
22
4080
|
|
GAG
ATPQDLNMM
200
9
12
19
4081
|
|
GAG
ATPQDLNTM
200
9
42
66
4082
|
|
GAG
IVGGIIQAAM
211
9
12
19
4083
|
|
GAG
TVGGIIQAAM
211
9
47
73
4084
|
|
GAG
AMQMLKDTI
218
9
33
52
4085
|
|
GAG
AMQMLKETI
218
9
26
41
4086
|
|
GAG
TINEEAAEW
225
9
53
83
4087
|
|
GAG
DIAGTTSTL
256
9
48
75
4088
|
|
GAG
TTSTLQEQI
260
9
45
71
4089
|
|
GAG
STLQEQIAW
262
9
12
19
4090
|
|
GAG
STLQEQIGW
262
9
27
42
4091
|
|
GAG
TLQEQIAWM
263
9
12
19
4092
|
|
GAG
TLQEQIGWM
263
9
27
42
4093
|
|
GAG
GWMTNNPPI
269
9
18
28
0.0140
4094
|
|
GAG
GWMTSNPPI
269
9
10
16
4095
|
|
GAG
PVGDIYKRW
281
9
18
28
4096
|
|
GAG
PVGEIYKRW
281
9
40
63
4097
|
|
GAG
DIYKRWIIL
284
9
17
27
4098
|
|
GAG
EIYKRWIIL
284
9
37
58
4099
|
|
GAG
WIILGLNKI
289
9
57
89
4100
|
|
GAG
GLNKIVRMY
293
9
60
94
4101
|
|
GAG
RMYSPTSIL
299
9
14
22
4102
|
|
GAG
RMYSPVSIL
299
9
40
63
4103
|
|
GAG
PFRDYVDRF
316
9
63
98
4104
|
|
GAG
YVDRFFKTL
320
9
27
42
4105
|
|
GAG
YVDRFYKTL
320
9
28
44
4106
|
|
GAG
ATQDVKNWM
333
9
15
23
4107
|
|
GAG
AIQEVKNWM
333
9
18
28
4108
|
|
GAG
NIMMQRGNF
407
9
10
17
4109
|
|
GAG
NIMMQRGNI
407
9
13
22
4110
|
|
GAG
CTERQANFL
459
9
55
87
4111
|
|
GAG
PTAPPAESF
495
9
20
31
4112
|
|
GAG
PTAPPEESF
495
9
15
23
4113
|
|
GAG
PTAPPAESF
507
9
02
67
4114
|
|
GAG
PTAPPPESF
507
9
01
33
4115
|
|
GAG
PIDKELYPL
534
9
12
19
4116
|
|
GAG
PIDKELYPL
538
9
01
25
4117
|
|
GAG
TIDKDLYPL
538
9
01
25
4118
|
|
GAG
PLASLKSLF
548
9
15
23
4119
|
|
GAG
PLTSLKSLF
548
9
12
19
4120
|
|
GAG
PLTSLRSLF
548
9
12
19
4121
|
|
GAG
VLSGGKLDAW
7
10
15
23
4122
|
|
GAG
KLDAWEKIRL
12
10
16
25
4123
|
|
GAG
KLDKWEKIRL
12
10
10
16
4124
|
|
GAG
RLRPGGKKKY
20
10
34
53
4125
|
|
GAG
VWASRELERF
36
10
45
70
4126
|
|
GAG
ETSEGCRQIL
54
10
14
22
4127
|
|
GAG
QILGQLQPSL
61
10
11
17
4128
|
|
GAG
QTGSEELRSL
71
10
12
19
4129
|
|
GAG
SLPNTVATLY
79
10
15
23
4130
|
|
GAG
SLYNTVATLY
79
10
22
34
4131
|
|
GAG
ATLYCVIIQKI
85
10
12
19
4132
|
|
GAG
ATLYCVIIQRI
85
10
15
23
4133
|
|
GAG
PIVQNAQGQM
154
10
21
33
4134
|
|
GAG
PIVQNLQGQM
154
10
29
45
4135
|
|
GAG
AISPRTLNAW
167
10
29
45
4136
|
|
GAG
ALSPRTLNAW
167
10
10
16
4137
|
|
GAG
RTLNAWVKVI
171
10
30
47
4138
|
|
GAG
WVKVIEEKAF
176
10
24
38
4139
|
|
GAG
WVKVVEEKAF
176
10
28
44
4140
|
|
GAG
AFSPEVIPMF
184
10
50
78
0.0078
4141
|
|
GAG
ATPQDLNMML
200
10
12
19
4142
|
|
GAG
ATPQDLNTML
200
10
42
66
4143
|
|
GAG
NIVGGIIQAAM
210
10
12
19
4144
|
|
GAG
NTVGGIIQAAM
210
10
47
73
4145
|
|
GAG
DTINEEAAEW
224
10
31
48
4146
|
|
GAG
ETINEEAAEW
224
10
22
34
4147
|
|
GAG
RLIIPVIIAGPI
235
10
22
34
4148
|
|
GAG
RVIIPVIIAGPI
235
10
14
22
4149
|
|
GAG
QMREPRGSDI
248
10
44
69
4150
|
|
GAG
GTTSTLQEQI
259
10
45
70
4151
|
|
GAG
STLQEQIAWM
262
10
12
19
4152
|
|
GAG
STLQEQIGWM
262
10
27
42
4153
|
|
GAG
PVGDIYKRWI
281
10
17
27
4154
|
|
GAG
PVGEIYKRWI
281
10
40
63
4155
|
|
GAG
IYKRWIILGL
285
10
54
84
0.0140
4156
|
|
GAG
RWIILGLNKI
288
10
56
88
4157
|
|
GAG
ILGLNKIVRM
291
10
57
89
4158
|
|
GAG
IVRMYSPTSI
297
10
14
22
4159
|
|
GAG
IVRMYSPVSI
297
10
40
63
4160
|
|
GAG
MYSPTSILDI
300
10
13
20
4161
|
|
GAG
MYSPVSILDI
300
10
40
63
4162
|
|
GAG
DIKQGPKEPF
308
10
19
30
4163
|
|
GAG
DIRQGPKEPF
308
10
41
64
4164
|
|
GAG
PFRDYVDRFF
316
10
35
55
4165
|
|
GAG
PFRDYVDRFY
316
10
28
44
4166
|
|
GAG
DYVDRFFKTL
319
10
27
42
4167
|
|
GAG
DYVDRFYKTL
319
10
28
44
0.0010
4168
|
|
GAG
DVKNWMTDT
336
10
12
19
4169
|
|
GAG
DVKNWMTET
336
10
11
17
4170
|
|
GAG
EVKNWMTETL
336
10
25
39
4171
|
|
GAG
ATIMMQRGNF
406
10
11
28
4172
|
|
GAG
CFNCGKEGIII
425
10
27
42
4173
|
|
GAG
CINCGKEGIIL
425
10
27
42
4174
|
|
GAG
TTPSQKQEPI
522
10
09
45
4175
|
|
GAG
ETIDKDLYPL
537
10
01
25
4176
|
|
GAG
RTENSLYPPL
538
10
01
25
4177
|
|
GAG
LYPLASLKSL
544
10
09
17
4178
|
|
GAG
SVLSGGKLDA
6
11
15
23
4179
|
|
GAG
IVWASRELERF
35
11
19
30
4180
|
|
GAG
LVWASRELER
35
11
25
39
4181
|
|
GAG
ELERFALNPGL
42
11
14
22
4182
|
|
GAG
ELERFAVNPGL
42
11
15
23
4183
|
|
GAG
LLETSEGCRQI
52
11
16
25
4184
|
|
GAG
RIEVKDTKEAL
93
11
12
19
4185
|
|
GAG
NLQGQMVIIQA
158
11
15
23
4186
|
|
GAG
MVIIQAISPRTL
163
11
27
42
4187
|
|
GAG
AWVKVIEEKA
175
11
24
38
4188
|
|
GAG
AWVKVVEEKA
175
11
28
44
4189
|
|
GAG
ALSEGATPQDL
195
11
58
91
4190
|
|
GAG
IVGGIIQAAMQ
211
11
11
17
4191
|
|
GAG
TVGGIIQAAMQ
211
11
47
73
4192
|
|
GAG
TTSTLQEQIA
260
11
11
17
4193
|
|
GAG
TTSTLQEQIG
260
11
27
43
4194
|
|
GAG
QIGWMTNNPPI
267
11
18
29
4195
|
|
GAG
QIGWMISNPPI
267
11
10
16
4196
|
|
GAG
PIPVGEIYKRW
279
11
34
53
4197
|
|
GAG
PVGDIYKRWII
281
11
17
27
4198
|
|
GAG
PVGEIYKRWII
281
11
39
61
4199
|
|
GAG
DIYKRWIILGL
284
11
17
27
4200
|
|
GAG
EIYKRWIILGL
284
11
37
58
4201
|
|
GAG
IILGLNKIVRM
290
11
56
88
4202
|
|
GAG
ILGLNKIVRMY
291
11
57
89
4203
|
|
GAG
KIVRMYSPTSI
296
11
14
22
4204
|
|
GAG
KIVRMYSPVSI
296
11
39
61
4205
|
|
GAG
IVRMYSPTSIL
297
11
14
22
4206
|
|
GAG
IVRMYSPVSIL
297
11
40
63
4207
|
|
GAG
RMYSPTSILDI
299
11
13
20
4208
|
|
GAG
RMYSPVSILDI
299
11
18
59
4209
|
|
GAG
DVKNWMTDT
336
11
12
19
4210
|
|
GAG
DVKNWMTET
336
11
11
17
4211
|
|
GAG
EVKNWMTETL
336
11
25
39
4212
|
|
GAG
ILKALGPAATL
357
11
16
25
4213
|
|
GAG
ALGPAATLEE
360
11
16
25
4214
|
|
GAG
ALGPGATLEE
360
11
17
27
4215
|
|
GAG
ATAQQDLKGG
392
11
01
50
4216
|
|
GAG
CWKCGKEGIIQ
446
11
46
72
4217
|
|
GAG
PTAPPAESFGF
495
11
10
16
4218
|
|
GAG
PTAPPEESFRF
495
11
14
22
4219
|
|
GAG
PTAPPAESFRF
507
11
02
67
4220
|
|
GAG
PTAPPPESFRF
507
11
01
33
4221
|
|
GAG
LYPLASLKSLF
544
11
09
17
4222
|
|
GAG
SLKSLFGNDPL
551
11
12
19
4223
|
|
NEF
DLEKIIGAI
57
8
14
22
4224
|
|
NEF
ATNADCAW
71
8
12
22
4225
|
|
NEF
PVRPQVPL
95
8
48
75
4226
|
|
NEF
PMTYKGAF
105
8
12
19
4227
|
|
NEF
TYKGAFDL
107
8
12
19
4228
|
|
NEF
AFDLSFFL
111
11
18
28
4229
|
|
NEF
ALDLSIIFL
111
8
11
17
4230
|
|
NEF
AVDLSIIFL
111
8
15
23
4231
|
|
NEF
FLKEKGGL
117
8
56
88
4232
|
|
NEF
DILDLWVY
185
8
20
31
4233
|
|
NEF
EILDLWVY
185
8
33
52
4234
|
|
NEF
WVYIITQGF
191
8
13
20
4235
|
|
NEF
WVYIITQGY
191
8
21
33
4236
|
|
NEF
VYIITQGFF
192
8
13
20
4237
|
|
NEF
VYIITQGYF
192
8
21
33
4238
|
|
NEF
FFPDWQNY
199
8
17
27
4239
|
|
NEF
YFPDWQNY
199
8
36
56
4240
|
|
NEF
NYTPGPGI
206
8
20
31
4241
|
|
NEF
GIRYPLTF
213
8
13
20
4242
|
|
NEF
GTRFPLTF
213
8
13
20
4243
|
|
NEF
RFPLTFGW
216
8
20
32
4244
|
|
NEF
RYPLTFGW
216
8
27
43
4245
|
|
NEF
PLTFGWCF
219
8
43
67
4246
|
|
NEF
TFGWCFKL
222
8
40
63
4247
|
|
NEF
GVGAASQDL
45
9
11
17
4248
|
|
NEF
GVGAVSQDL
45
9
21
33
4249
|
|
NEF
GVGAVSRDL
45
9
17
27
4250
|
|
NEF
ATNADCAWL
71
9
12
22
4251
|
|
NEF
QVPLRPMTF
100
9
10
16
4252
|
|
NEF
QVPLRPMTY
100
9
46
72
4253
|
|
NEF
MTYKGAFDL
106
9
12
19
4254
|
|
NEF
FFLKEKGGL
116
9
26
41
4255
|
|
NEF
IIFLKEKGGL
116
9
29
45
4256
|
|
NEF
IYSKKRQEI
175
9
18
29
4257
|
|
NEF
LWVYIITQGF
190
9
13
20
4258
|
|
NEF
LWVYIIIQGY
190
9
21
33
4259
|
|
NEF
WVYIITQGFF
191
9
13
20
4260
|
|
NEF
WVYIITQGYF
191
9
21
33
4261
|
|
NEF
FITQGFFPDW
194
9
14
22
4262
|
|
NEF
IITQGYFPDW
194
9
25
39
4263
|
|
NEF
NTQGYFPDW
194
9
12
19
4264
|
|
NEF
CFFPDWQNY
198
9
17
27
4265
|
|
NEF
GYFPDWQNY
198
9
36
56
0.0002
4266
|
|
NEF
YTPGPGIRY
207
9
17
27
4267
|
|
NEF
YTPGPGTRF
207
9
13
20
4268
|
|
NEF
LTFGWCFKL
221
9
39
61
4269
|
|
NEF
KWSKSSIVGW
4
10
20
31
4270
|
|
NEF
GFPVRPQVPL
93
10
48
75
4271
|
|
NEF
PMTYKGAFDL
105
10
12
19
4272
|
|
NEF
SFFLKEKGGL
115
10
22
34
4273
|
|
NEF
LIYSKKRQEI
174
10
18
28
4274
|
|
NEF
IYSKKRQEIL
175
10
18
29
4275
|
|
NEF
DLWVYIITQGF
188
10
13
20
4276
|
|
NEF
DLWVYIITQGY
188
10
21
33
4277
|
|
NEF
LWVYIITQGFF
190
10
13
20
4278
|
|
NEF
LWVYIIIQGYF
190
10
21
33
4279
|
|
NEF
NYTPGPGIRY
206
10
17
27
4280
|
|
NEF
NYTPGPGTRF
206
10
13
20
4281
|
|
NEF
GIRYPLTFGW
213
10
13
20
4282
|
|
NEF
GTRFPLTFGW
213
10
12
19
4283
|
|
NEF
RPPLTFGWCF
216
10
17
27
4284
|
|
NEF
RYPLTFGWCF
216
10
21
33
4285
|
|
NEF
PLTFGWCFKL
219
10
39
61
4286
|
|
NEF
LLHPICQHGM
257
10
10
16
4287
|
|
NEF
LLHPMSQHGM
257
10
12
19
4288
|
|
NEF
FIMARELHPEY
320
10
10
16
4289
|
|
NEF
NTAATNADCA
68
11
12
19
4290
|
|
NEF
PVRPQVPLRP
95
11
47
73
4291
|
|
NEF
PLRPMTYKGA
102
11
12
19
4292
|
|
NEF
FLKEKGGLDGL
117
11
26
41
4293
|
|
NEF
FLKEKGGLEGL
117
11
29
45
4294
|
|
NEF
GLIYSKKRQEI
173
11
18
28
4295
|
|
NEF
LIYSKKRQEIL
174
11
18
28
4296
|
|
NEF
DLWVYHTQGF
188
11
13
20
4297
|
|
NEF
DLWVYHTQGY
188
11
21
33
4298
|
|
NEF
VYHTQGFFPD
192
11
13
20
4299
|
|
NEF
VYHTQGYFPD
192
11
21
33
4300
|
|
NEF
DWQNYTPGPG
203
11
18
28
4301
|
|
NEF
YTPGPGIRYPL
207
11
16
25
4302
|
|
NEF
YTPGPGTRFPL
207
11
13
20
4303
|
|
NEF
CLLHPMSQIIG
256
11
10
16
4304
|
|
NEF
HMARELHPEY
320
11
10
16
4305
|
|
POL
FFREDLAF
1
8
15
23
4306
|
|
POL
FFRENLAF
1
8
41
64
4307
|
|
POL
GTLNCVQI
80
8
01
33
4308
|
|
POL
PTFNFPQI
80
8
01
33
4309
|
|
POL
NFVQITLW
86
8
22
34
4310
|
|
POL
SFVQITLW
86
8
23
36
4311
|
|
POL
ITLWQRVL
90
8
47
73
4312
|
|
POL
TIKIGGQL
99
8
17
27
4313
|
|
POL
TVKIGGQL
99
8
11
17
4314
|
|
POL
TVLEDINL
118
8
13
20
4315
|
|
POL
TVLEEINL
118
8
15
23
4316
|
|
POL
DINLVGKW
122
8
13
20
4317
|
|
POL
EINLVGKW
122
8
12
19
4318
|
|
POL
MIGGIGCW
133
8
62
97
4319
|
|
POL
GFIKVRQY
139
8
53
83
4320
|
|
POL
KVRQYDQI
142
8
41
64
4321
|
|
POL
EICGIIKAI
152
8
19
30
4322
|
|
POL
EICGKKAI
152
8
24
38
4323
|
|
POL
NIIGRNLL
170
8
26
41
4324
|
|
POL
NIIGRNML
170
8
31
48
4325
|
|
POL
LTQIGCTL
177
8
42
66
4326
|
|
POL
LTQLGCTL
177
8
15
23
4327
|
|
POL
QIGCTLNF
179
8
41
64
4328
|
|
POL
QLGCTLNF
179
8
16
25
4329
|
|
POL
PVKLKPGM
195
8
56
88
4330
|
|
POL
KIKALTEI
217
8
28
44
4331
|
|
POL
KIKALVEI
217
8
15
23
4332
|
|
POL
LVEICTEM
221
8
15
24
4333
|
|
POL
EMEKEGKI
229
8
42
66
4334
|
|
POL
KIGVENVY
238
8
51
80
4335
|
|
POL
RIGVENVY
238
8
11
17
4336
|
|
POL
KWRKLVDF
259
8
59
92
4337
|
|
POL
KLVDFREL
262
8
63
98
4338
|
|
POL
FWEVQLGI
276
8
57
89
4339
|
|
POL
GIVHVAGL
282
8
56
89
4340
|
|
POL
VLDVGDAY
297
8
60
94
4341
|
|
POL
SVVLDKDF
306
8
18
28
4342
|
|
POL
DFRKYTAF
312
8
42
66
4343
|
|
POL
GWKGSVAI
341
8
59
92
4344
|
|
POL
MTKILEPF
353
8
44
69
4345
|
|
POL
DIVIYQYM
366
8
18
28
4346
|
|
POL
EIYIYQYM
366
8
24
38
4347
|
|
POL
IYQYMDDL
369
8
61
95
4348
|
|
POL
DLYVGSDL
375
8
63
98
4349
|
|
POL
YVGSDLEI
377
8
58
91
4350
|
|
POL
FLWMGYEL
416
8
64
100
4351
|
|
POL
WTVQVIQL
428
8
28
44
4352
|
|
POL
WTVQVIVL
428
8
13
20
4353
|
|
POL
QLVEKDSW
434
8
13
20
4354
|
|
POL
VLPEKDSW
434
8
13
20
4355
|
|
POL
TVNDIQKL
442
8
62
97
4356
|
|
POL
KLVGKLNW
448
8
62
97
4357
|
|
POL
KLNWASQI
452
8
61
95
4358
|
|
POL
KVKQLCKL
464
8
29
45
4359
|
|
POL
KVRQLCKL
464
8
19
30
4360
|
|
POL
LLRGAKAL
471
8
30
47
4361
|
|
POL
LLRGTKAL
471
8
24
38
4362
|
|
POL
ALTDIVPL
477
8
21
33
4363
|
|
POL
ALTEVIPL
477
8
16
25
4364
|
|
POL
PLTEEAEL
483
8
30
47
4365
|
|
POL
ELAENREI
491
8
57
89
4366
|
|
POL
YYDPSKDL
510
8
43
67
4367
|
|
POL
KTGKYAKM
542
8
19
30
4368
|
|
POL
KTGKYARM
542
8
13
21
4369
|
|
POL
IITNDVKQL
553
8
49
77
4370
|
|
POL
LTEAVQKI
560
8
34
53
4371
|
|
POL
ATESIVIW
568
8
19
30
4372
|
|
POL
IWGKIPKF
574
8
11
17
4373
|
|
POL
IWGKTPKF
574
8
48
75
4374
|
|
POL
ETWWTDYW
591
8
10
16
4375
|
|
POL
DYWQATWI
596
8
20
31
4376
|
|
POL
EYWQATWI
596
8
37
58
4377
|
|
POL
TWIPEWEF
601
8
52
81
4378
|
|
POL
EFVNTPPL
607
8
54
84
4379
|
|
POL
NTPPLVKL
610
8
57
89
4380
|
|
POL
LVKLWYQL
614
8
58
91
4381
|
|
POL
PIVGAETP
625
8
28
44
4382
|
|
POL
IVGAETFY
626
8
28
44
4383
|
|
POL
TTNQKTEL
664
8
55
86
4384
|
|
POL
KTELQAIY
668
8
12
19
4385
|
|
POL
NIVTDSQY
686
8
62
97
4386
|
|
POL
VTDSQYAL
688
8
59
92
4387
|
|
POL
LIKKEKVY
717
8
35
55
4388
|
|
POL
WVPAHKGI
727
8
63
98
4389
|
|
POL
GIRKVLFL
747
8
51
80
4390
|
|
POL
KVLFLDGI
750
8
50
78
4391
|
|
POL
AMASDFNL
773
8
45
70
4392
|
|
POL
QVDCSPGI
805
8
57
89
4393
|
|
POL
CTHLEGKI
817
8
35
55
4394
|
|
POL
IILEGKIIL
819
8
31
48
4395
|
|
POL
IILEGKVIL
819
8
23
36
4396
|
|
POL
AVIIVASGY
828
8
59
92
4397
|
|
POL
GYIEAEVI
834
8
54
84
4398
|
|
POL
ETGQETAY
844
8
59
92
4399
|
|
POL
ILKLAGRW
853
8
34
53
4400
|
|
POL
LLKLAGRW
853
8
25
39
4401
|
|
POL
HTDNGSNF
866
8
51
80
4402
|
|
POL
TTVKAACW
876
8
15
23
4403
|
|
POL
AVKAACWW
877
8
32
50
4404
|
|
POL
TVKAACWW
877
8
24
38
4405
|
|
POL
GIKQEFGI
886
8
22
34
4406
|
|
POL
GIQQEFGI
886
8
11
17
4407
|
|
POL
IILKTAVQM
923
8
57
89
4408
|
|
POL
AVQMAVPI
927
8
60
94
4409
|
|
POL
NFKRKGGI
936
8
60
94
4410
|
|
POL
GYSAGERI
945
8
57
89
4411
|
|
POL
QIIKIQNF
968
8
12
19
4412
|
|
POL
QITKIQNF
968
8
35
55
4413
|
|
POL
KIQNFRVY
971
8
52
81
4414
|
|
POL
IWKGPAKL
986
8
36
56
4415
|
|
POL
LWKGPAKL
986
8
19
30
4416
|
|
POL
VIQDNSDI
1003
8
37
58
4417
|
|
POL
VIQDNSEI
1003
8
12
19
4418
|
|
POL
PTRRELQVW
30
9
13
20
4419
|
|
POL
GTTLNFPQI
79
9
01
17
4420
|
|
POL
AISLSLPQI
80
9
01
33
4421
|
|
POL
SFSFPQIPL
84
9
14
22
4422
|
|
POL
QTTLWQRPL
89
9
47
73
4423
|
|
POL
LWQRPLVTI
92
9
21
33
0.0190
4424
|
|
POL
VTIKIGGQL
98
9
17
27
4425
|
|
POL
VTVKIGGQL
98
9
11
17
4426
|
|
POL
DTGADDTVL
112
9
61
95
4427
|
|
POL
DTVLEDINL
117
9
13
20
4428
|
|
POL
DTVLEEINL
117
9
14
22
4429
|
|
POL
KMIGGIGGF
132
9
62
97
0.0011
4430
|
|
POL
MIGGIGGFI
133
9
62
97
4431
|
|
POL
KVRQYDQIL
142
9
21
33
4432
|
|
POL
QYDQILIEI
145
9
27
42
4433
|
|
POL
QYDQIPIEI
145
9
12
19
4434
|
|
POL
LVGPTPVNI
163
9
54
84
4435
|
|
POL
PVNIIGRNL
168
9
26
41
4436
|
|
POL
PVNIIGRNM
168
9
24
38
4437
|
|
POL
LLTQIGCTL
176
9
21
33
4438
|
|
POL
MLTQIGCTL
176
9
18
28
4439
|
|
POL
MLTQLGCTL
176
9
10
16
4440
|
|
POL
TLNFPISPI
183
9
61
97
4441
|
|
POL
PIETVPVKL
190
9
53
83
4442
|
|
POL
QWPLTEEKI
210
9
56
88
4443
|
|
POL
LTEEKIKAL
213
9
56
88
4444
|
|
POL
ALVEICTEM
220
9
15
23
4445
|
|
POL
PYNTPIFAI
244
9
24
38
4446
|
|
POL
PYNTPVFAI
244
9
37
58
0.0310
4447
|
|
POL
ELNKRTQDF
268
9
57
89
4448
|
|
POL
DFWEVQLGI
275
9
56
88
4449
|
|
POL
TVLDVGDAY
296
9
57
89
4450
|
|
POL
VLDVGDAYF
297
9
60
94
4451
|
|
POL
PLDKDFRKY
308
9
19
30
4452
|
|
POL
YTAFTIPSI
316
9
37
S8
4453
|
|
POL
SINNETPGI
323
9
32
50
4454
|
|
POL
STNNETPGI
323
9
11
17
4455
|
|
POL
ETPGIRYQY
327
9
52
81
4456
|
|
POL
GIRYQYNVL
330
9
52
81
4457
|
|
POL
QYNVLPQGW
334
9
63
98
0.0036
4458
|
|
POL
GWKGSPAIF
341
9
59
92
4459
|
|
POL
IFQSSMTKI
348
9
38
59
0.0029
4460
|
|
POL
SMTKILEPF
352
9
43
67
0.0110
4461
|
|
POL
PFRKQNPDI
359
9
16
25
4462
|
|
POL
VIYQYMDDL
368
9
51
80
4463
|
|
POL
IYQYMDDLY
369
9
61
95
0.0130
4464
|
|
POL
LYVGSDLEI
376
9
58
91
4465
|
|
POL
EIGQIIRAKI
383
9
26
41
4466
|
|
POL
EIGQIIRTKI
383
9
21
33
4467
|
|
POL
KIEELREIIL
390
9
19
30
4468
|
|
POL
KIEELRQIIL
390
9
17
27
4469
|
|
POL
ELREIILLKW
393
9
17
27
4470
|
|
POL
ELRQIILLRW
393
9
15
23
4471
|
|
POL
PFLWMGYEL
415
9
64
100
4472
|
|
POL
GYELIIPDKW
420
9
60
94
0.0001
4473
|
|
POL
KWIVQPIQL
427
9
28
44
4474
|
|
POL
KWTVQPIVL
427
9
12
19
4475
|
|
POL
IVLPEKDSW
433
9
13
20
4476
|
|
POL
WIVNDIQKL
441
9
62
97
4477
|
|
POL
DIQKLVGKL
445
9
62
97
4478
|
|
POL
KLNWASQIY
452
9
60
94
4479
|
|
POL
KVKQLCKLL
464
9
28
44
4480
|
|
POL
KVRQLCKLL
464
9
19
30
4481
|
|
POL
KLLRGAKAL
470
9
25
40
4482
|
|
POL
KLLRGTKAL
470
9
24
38
4483
|
|
POL
GTKALTEVI
474
9
11
17
4484
|
|
POL
LTEEAELEL
484
9
37
58
4485
|
|
POL
ELAENREIL
491
9
57
89
4486
|
|
POL
VYYDPSKDL
509
9
39
61
0.0004
4487
|
|
POL
YYDPSKDLI
510
9
35
55
4488
|
|
POL
TYQIYQEPF
530
9
42
66
0.3000
4489
|
|
POL
IYQEPIKNL
533
9
40
63
0.0520
4490
|
|
POL
QLTEAVQKI
559
9
34
53
4491
|
|
POL
KIATESIVI
566
9
14
22
4492
|
|
POL
VIWGKTPKF
573
9
47
73
4493
|
|
POL
KTPKFKLPI
577
9
17
27
4494
|
|
POL
KTPKFRLPI
577
9
29
45
4495
|
|
POL
KLPIQKETW
582
9
20
31
4496
|
|
POL
RLPIQKETW
582
9
26
41
4497
|
|
POL
TWETWWTDY
589
9
10
16
4498
|
|
POL
TWETWWTEY
589
9
10
16
4499
|
|
POL
WTDYWQATW
594
9
14
22
4500
|
|
POL
WTEYWQATW
S94
9
24
38
4501
|
|
POL
ATWIPEWEF
600
9
52
81
4502
|
|
POL
NTPPLVKLW
610
9
57
89
4503
|
|
POL
PLVKLWYQL
613
9
54
84
4504
|
|
POL
WYQLEKDPI
618
9
14
22
4505
|
|
POL
WYQLEKEPI
618
9
31
48
0.0001
4506
|
|
POL
WYQLETEPI
618
9
11
17
4507
|
|
POL
PIVGAETFY
625
9
28
44
4508
|
|
POL
ETKLCKACY
641
9
35
55
4509
|
|
POL
DTTNQKTEL
663
9
26
41
4510
|
|
POL
ETTNQKTEL
663
9
29
45
4511
|
|
POL
KTELQAIIIL
668
9
15
23
4512
|
|
POL
KTCLQAIYL
668
9
12
19
4513
|
|
POL
ELQAIIILAL
670
9
16
25
4514
|
|
POL
ELQAIYLAL
670
9
12
19
4515
|
|
POL
IILALQDSGL
675
9
15
23
4516
|
|
POL
IVTDSQYAL
687
9
59
92
4517
|
|
POL
LVNQIIEQL
709
9
19
30
4518
|
|
POL
LVSQIIEQL
709
9
19
30
4519
|
|
POL
QLIKKEKVY
716
9
28
44
4520
|
|
POL
LIKKEKVYL
717
9
35
55
4521
|
|
POL
AWVPAIIKGI
726
9
22
34
4522
|
|
POL
SWVPAIIKGI
726
9
37
58
4523
|
|
POL
KYIISNWRAM
766
9
28
44
4524
|
|
POL
RYIISNWRAM
766
9
11
17
4525
|
|
POL
NWRAMASDF
770
9
43
67
0.0016
4526
|
|
POL
QVDCSPGIW
805
9
57
89
4527
|
|
POL
IWQLDCTIIL
812
9
59
92
0.0095
4528
|
|
POL
CTIILEGKII
817
9
35
55
4529
|
|
POL
CTIILEGKVI
817
9
26
41
4530
|
|
POL
AVIIVASGYI
828
9
53
83
4531
|
|
POL
ETGQETAYF
844
9
57
89
4532
|
|
POL
ETAYFILKL
848
9
31
48
4533
|
|
POL
ETAYFLLKL
848
9
27
42
4534
|
|
POL
FILKLAGRW
852
9
32
50
4535
|
|
POL
FLLKLAGRW
852
9
25
39
4536
|
|
POL
STTVKAACW
875
9
15
23
4537
|
|
POL
TTVKAACWW
876
9
15
23
4538
|
|
POL
WWAGIKQEF
883
9
21
33
0.0120
4539
|
|
POL
WWAGIQQEF
883
9
11
17
4540
|
|
POL
VVESMNKEL
902
9
48
75
4541
|
|
POL
SMNKELKKI
905
9
53
83
4542
|
|
POL
QVRDQAEHL
916
9
48
75
4543
|
|
POL
QVREQAEIIL
916
9
13
20
4544
|
|
POL
KTAVQMAVF
925
9
57
89
4545
|
|
POL
QMAVFIIINF
929
9
60
94
0.0190
4546
|
|
POL
GYSAGERII
945
9
41
64
4547
|
|
POL
IIDIIASDI
952
9
12
19
4548
|
|
POL
IIDIIATDI
952
9
29
45
4549
|
|
POL
IVDIIATDI
952
9
12
19
4550
|
|
POL
ATDIQTKEL
957
9
35
55
4551
|
|
POL
QTKELQKQI
961
9
46
72
4552
|
|
POL
ELQKQIIKI
964
9
13
21
4553
|
|
POL
ELQKQITKI
964
9
34
S4
4554
|
|
POL
KIQNFRVYY
971
9
52
81
4555
|
|
POL
YYRDSRDPI
978
9
34
53
4556
|
|
POL
YYRDSRDPL
978
9
14
22
4557
|
|
POL
PIWKGPAKL
985
9
36
56
4558
|
|
POL
PLWKGPAKL
985
9
19
30
4559
|
|
POL
IWKGPAKLL
986
9
35
55
4560
|
|
POL
LWKGPAKLL
986
9
18
28
4561
|
|
POL
VVIQDNSDI
1002
9
37
58
4562
|
|
POL
VVIQDNSEI
1002
9
12
19
4563
|
|
POL
VVPRRKAKI
1012
9
51
80
4564
|
|
POL
VVPRRKVKI
1012
9
11
17
4565
|
|
POL
IIKDYGKQM
1020
9
11
17
4566
|
|
POL
IIRDYGKQM
1020
9
50
78
4567
|
|
POL
AFPQGEAREF
7
10
10
16
4568
|
|
POL
STNSPTSREL
32
10
01
33
4569
|
|
POL
GTLNCPQITL
80
10
01
33
4570
|
|
POL
PTFNFPQIIL
80
10
01
33
4571
|
|
POL
SFSFPQITLW
84
10
13
20
4572
|
|
POL
TLWQRPLVTI
91
10
21
33
4573
|
|
POL
LVTIKIGGQL
97
10
13
20
4574
|
|
POL
KIGCQLKEAL
101
10
23
36
4575
|
|
POL
NLPGKWKPKM
124
10
35
55
4576
|
|
POL
KWKPKMIGGI
128
10
42
66
4577
|
|
POL
RWKPKMIGGI
128
10
17
27
4578
|
|
POL
KMIGGIGGFI
132
10
62
97
0.0001
4579
|
|
POL
FIKVRQYDQI
140
10
41
64
4580
|
|
POL
KVRQYDQILI
142
10
20
31
4581
|
|
POL
KVRQYDQIPI
142
10
13
20
4582
|
|
POL
LIEICGIIKAI
150
10
10
16
4583
|
|
POL
LIEICGKKAI
150
10
13
20
4584
|
|
POL
VLVGPTPVNI
162
10
53
83
4585
|
|
POL
LVGPIPVNLL
163
10
52
81
4586
|
|
POL
PVNIIGRNLL
168
10
26
41
4587
|
|
POL
PVNIIGRNML
168
10
24
38
4588
|
|
POL
IIGRNLLIQI
171
10
21
33
4589
|
|
POL
IIGRNMLTQI
171
10
18
28
4590
|
|
POL
IIGRNMLTQL
171
10
11
17
4591
|
|
POL
NLLTQIGCTL
175
10
21
33
4592
|
|
POL
NMLTQIGCTL
175
10
18
28
4593
|
|
POL
NMLTQLGCTL
175
10
10
16
4594
|
|
POL
LTQIGCTLNF
177
10
41
64
4595
|
|
POL
LTQLGCTLNF
177
10
15
23
4596
|
|
POL
QIGCTLNFPI
179
10
41
64
4597
|
|
POL
QLGCTLNFPI
179
10
16
25
4598
|
|
POL
CTLNFPISPI
182
10
60
94
4599
|
|
POL
TVPVKLKPGM
193
10
54
84
4600
|
|
POL
GMDGPKVKQ
201
10
51
80
4601
|
|
POL
PLTEEKIKAL
212
10
54
84
4602
|
|
POL
CTEMEKEGKI
225
10
27
42
4603
|
|
POL
AIKKKDSTKW
251
10
57
89
4604
|
|
POL
STKWRKLVDF
257
10
58
91
4605
|
|
POL
ELNKRTQDFW
268
10
57
89
4606
|
|
POL
RTQDFWEVQL
272
10
53
83
4607
|
|
POL
QLGIPIIPAGL
280
10
56
89
4608
|
|
POL
VTVLDVGDAY
295
10
56
88
4609
|
|
POL
TVLDVCDAYF
296
10
57
89
4610
|
|
POL
YFSVPLDKDF
304
10
18
29
4611
|
|
POL
DFRKYTAFTI
312
10
42
66
4612
|
|
POL
KYTAFTIPSI
315
10
37
58
4613
|
|
POL
AIFQSSMTKI
347
10
36
56
4614
|
|
POL
IFQSSMTKIL
348
10
38
59
0.0002
4615
|
|
POL
IVIYQYMDDL
367
10
42
66
4616
|
|
POL
VIYQYMDDLY
368
10
51
80
4617
|
|
POL
DLYVGSDLEI
375
10
58
91
4618
|
|
POL
KIEELREIILL
390
10
19
30
4619
|
|
POL
KIEELRQIILL
390
10
17
27
4620
|
|
POL
PIQLPEKDSW
432
10
13
20
4621
|
|
POL
PIVLPEKDSW
432
10
13
20
4622
|
|
POL
SWTVNDIQKL
440
10
54
84
4623
|
|
POL
NWASQIYAGI
454
10
27
42
4624
|
|
POL
NWASQIYPGI
454
10
29
45
4625
|
|
POL
IYAGIKVKQL
459
10
18
28
4626
|
|
POL
IYPGIKVKQL
459
10
11
17
4627
|
|
POL
IYPGIKVRQL
459
10
15
23
4628
|
|
POL
GIKVKQLCKL
462
10
28
44
4629
|
|
POL
GIKVRQLCKL
462
10
18
28
4630
|
|
POL
IVPLTEEAEL
481
10
13
20
4631
|
|
POL
VIPLTEEAEL
481
10
11
17
4632
|
|
POL
PLTEEAELEL
483
10
30
47
4633
|
|
POL
ELELAENREI
489
10
53
83
4634
|
|
POL
ILKEPVIIGVY
498
10
40
63
4635
|
|
POL
GVYYDPSKDL
508
10
38
59
4636
|
|
POL
VYYDPSKDLI
509
10
31
48
0.0150
4637
|
|
POL
EIQKQGQDQW
520
10
13
20
4638
|
|
POL
EIQKQGQGQW
520
10
15
23
4639
|
|
POL
WTYQIYQEPF
529
10
42
66
4640
|
|
POL
QIYQEPFKNL
532
10
40
63
4641
|
|
POL
PFKNLKTGKY
537
10
45
70
4642
|
|
POL
NLKTGKYAKM
540
10
18
29
4643
|
|
POL
NLKTGKYARM
540
10
13
21
4644
|
|
POL
AVQKIATESI
563
10
10
16
4645
|
|
POL
KIATESIVIW
566
10
14
22
4646
|
|
POL
IVIWGKTPKF
572
10
47
73
4647
|
|
POL
IWGKTPKFKL
574
10
17
27
4648
|
|
POL
IWGKTPKFRL
574
10
30
47
4649
|
|
POL
PIQKETWEAW
584
10
15
23
4650
|
|
POL
PIQKETWETW
584
10
27
42
4651
|
|
POL
ETWETWWTD
588
10
10
16
4652
|
|
POL
ETWETWWTE
588
10
10
16
4653
|
|
POL
TWETWWTDY
589
10
10
16
4654
|
|
POL
WWTDYWQAT
593
10
14
22
4655
|
|
POL
WWTEYWQAT
593
10
23
36
4656
|
|
POL
WTDYWQATW
594
10
14
22
4657
|
|
POL
WTEYWQATW
594
10
24
38
4658
|
|
POL
YWQATWIPE
597
10
52
81
0.0660
4659
|
|
POL
EWEFVNTPPL
605
10
50
78
4660
|
|
POL
FVNTPPLVKL
608
10
54
86
4661
|
|
POL
NTPPLVKLWY
610
10
57
89
4662
|
|
POL
LWYQLEKDPI
617
10
14
22
4663
|
|
POL
LWYQLEKEPI
617
10
31
48
4664
|
|
POL
LWYQLETEPI
617
10
11
17
4665
|
|
POL
EVNIVTDSQY
684
10
59
92
4666
|
|
POL
NIVTDSQYAL
686
10
59
92
4667
|
|
POL
VTDSQYALGI
688
10
58
91
4668
|
|
POL
ELVNQIIEQL
708
10
18
28
4669
|
|
POL
ELVSQIIEQL
708
10
19
30
4670
|
|
POL
LVNQIIEQLI
709
10
19
30
4671
|
|
POL
LVSQIIEQLI
709
10
19
30
4672
|
|
POL
QLIKKEKVYL
716
10
28
44
4673
|
|
POL
QVDKLVSAGI
739
10
15
23
4674
|
|
POL
QVDKLVSSGI
739
10
29
45
4675
|
|
POL
LVSAGIRKVL
743
10
15
23
4676
|
|
POL
LVSSGIRKVL
743
10
26
41
4677
|
|
POL
NLPPIVAKCI
779
10
26
41
4678
|
|
POL
NLPPVVAKEI
779
10
27
42
4679
|
|
POL
IVASCDKCQL
788
10
43
67
4680
|
|
POL
GIWQLDCTHL
811
10
59
92
4681
|
|
POL
CTIILEGKIIL
817
10
31
48
4682
|
|
POL
CTIILEGKVIL
817
10
23
36
4683
|
|
POL
LYAVIIVASGY
826
10
53
83
4684
|
|
POL
ETGQETAYFI
844
10
31
48
4685
|
|
POL
EIGQETAYFL
844
10
26
41
4686
|
|
POL
YFILKLAGRW
851
10
31
48
4687
|
|
POL
YPLLKLAGRW
851
10
25
39
4688
|
|
POL
TIIITDNGSNF
864
10
14
22
4689
|
|
POL
VIIITDNGSNF
864
10
24
38
4690
|
|
POL
STTVKAACW
875
10
15
23
4691
|
|
POL
CWWAGIKQEF
882
10
21
33
4692
|
|
POL
CWWAGIQQEF
882
10
11
17
4693
|
|
POL
GIKQEFGIPY
886
10
22
34
4694
|
|
POL
GIQQEFGIPY
886
10
11
17
4695
|
|
POL
GVVESMNKEL
901
10
48
75
4696
|
|
POL
SMNKELKKII
905
10
53
83
4697
|
|
POL
KTAVQMAVFI
925
10
56
88
4698
|
|
POL
RIIDIIASDI
951
10
12
19
4699
|
|
POL
RIIDIIATDI
951
10
29
4S
4700
|
|
POL
RIVDIIATDI
951
10
12
19
4701
|
|
POL
QTKELQKQII
961
10
10
16
4702
|
|
POL
IIKIQNFRVY
969
10
12
19
4703
|
|
POL
ITKIQNFRVY
969
10
36
57
4704
|
|
POL
VYYRDSRDPI
977
10
34
53
4705
|
|
POL
VYYRDSRDPL
977
10
14
22
4706
|
|
POL
YYRDSRDPIW
978
10
34
53
4707
|
|
POL
YYRDSRDPLW
978
10
14
22
4708
|
|
POL
PIWKGPAKLL
985
10
35
55
4709
|
|
POL
PLWKGPAKLL
985
10
18
28
4710
|
|
POL
IWKGPAKLLW
986
10
35
55
4711
|
|
POL
LWKGPAKLLW
986
10
18
28
4712
|
|
POL
LWKGEGAVVI
994
10
59
92
4713
|
|
POL
AVVIQDNSDI
1000
10
37
58
4714
|
|
POL
AVVIQDNSEI
1000
10
12
19
4715
|
|
POL
KVVPRRKAKI
1011
10
51
80
4716
|
|
POL
KVVPRRKVKI
1011
10
11
17
4717
|
|
POL
VVPRRKAKII
1012
10
50
78
4718
|
|
POL
VVPRRKVKII
1012
10
11
17
4719
|
|
POL
KIIKDYGKQM
1019
10
11
17
4720
|
|
POL
KIIRDYGKQM
1019
10
50
78
4721
|
|
POL
LGTILNFPQITF
79
11
01
17
4722
|
|
POL
AISLSLPQITL
80
11
01
33
4723
|
|
POL
GTLNCPQITL
80
11
01
33
4724
|
|
POL
PTFNFPQITLW
80
11
01
33
4725
|
|
POL
ITLWQRPLVTI
90
11
19
30
4726
|
|
POL
LWQRPLVIIKI
92
11
14
22
4727
|
|
POL
LWQRPLVTVK
92
11
12
19
4728
|
|
POL
PLVTIKIGGQL
96
11
13
20
4729
|
|
POL
KIGGQLKEALL
101
11
23
36
4730
|
|
POL
LLDTGADDTV
110
11
61
95
4731
|
|
POL
VLEDINLPGKW
119
11
13
20
4732
|
|
POL
VLEDINLPGKW
119
11
12
19
4733
|
|
POL
NLPGKWKPKM
124
11
35
55
4734
|
|
POL
GIGGFIKVRQY
136
11
53
83
4735
|
|
POL
GFIKVRQYDQI
139
11
41
64
4736
|
|
POL
FIKVRQYDQIL
140
11
21
33
4737
|
|
POL
ILIDICGKKAI
149
11
13
20
4738
|
|
POL
TVLVGPTPVNI
161
11
53
83
4739
|
|
POL
VLVGPTPVNII
162
11
51
80
4740
|
|
POL
PTPVNIIGRNL
166
11
26
41
4741
|
|
POL
PTPVNIIGRNM
166
11
24
38
4742
|
|
POL
NIIGRNLLTQI
170
11
21
33
4743
|
|
POL
NIIGRNMLTQI
170
11
18
28
4744
|
|
POL
NIIGRNMLIQL
170
11
11
17
4745
|
|
POL
LLIQIGCTLNF
176
11
21
33
4746
|
|
POL
MLTQIGCTLNF
176
11
17
27
4747
|
|
POL
MLTQLGCTLN
176
11
10
16
4748
|
|
POL
ETVPVKLKPG
192
11
51
80
4749
|
|
POL
EMEKEGKISKI
229
11
32
50
4750
|
|
POL
KISKIGPENPY
235
11
41
64
4751
|
|
POL
KISRIGPENPY
235
11
11
17
4752
|
|
POL
KWRKLVDFRE
259
11
59
92
4753
|
|
POL
GLKKKKSVTV
288
11
49
77
4754
|
|
POL
SVTVLDVGDA
294
11
56
88
4755
|
|
POL
VTVLDVGDAY
295
11
56
88
4756
|
|
POL
DVGDAYFSVP
299
11
54
84
4757
|
|
POL
AYFSVPLDKDF
303
11
18
28
4758
|
|
POL
SVPLDKDFRK
306
11
18
28
4759
|
|
POL
SINNETPGIRY
323
11
32
50
4760
|
|
POL
STNNETPGIRY
323
11
11
17
4761
|
|
POL
RYQYNVLPQG
332
11
63
98
4762
|
|
POL
AWQSSMTKIL
347
11
36
56
4763
|
|
POL
PFRKQNPDIVI
359
11
14
22
4764
|
|
POL
DIVIYQYMDDL
366
11
18
28
4765
|
|
POL
EIVIYQYMDDL
366
11
24
38
4766
|
|
POL
IVIYQYMDDLY
367
11
42
66
4767
|
|
POL
YMDDLYVGSD
372
11
61
95
4768
|
|
POL
DLEIGQIIRAKI
381
11
26
41
4769
|
|
POL
DLEIGQIIRTKI
381
11
20
31
4770
|
|
POL
RTKIEELRQIIL
388
11
14
22
4771
|
|
POL
ELREIILLKWG
393
11
14
22
4772
|
|
POL
ELRQIILLRWG
393
11
12
39
4773
|
|
POL
WMGYELIIPDK
418
11
60
94
4774
|
|
POL
DIQKLVGKLN
445
11
62
97
4775
|
|
POL
LVGKLNWASQ
449
11
60
94
4776
|
|
POL
QIYAGIKVKQL
458
11
18
29
4777
|
|
POL
QIYPGIKVKQL
458
11
11
17
4778
|
|
POL
QIYPGIKVRQL
458
11
14
22
4779
|
|
POL
GIKVKQLCKLL
462
11
27
42
4780
|
|
POL
GIKVRQLCKLL
462
11
18
28
4781
|
|
POL
LLRGAKALTDI
473
11
22
34
4782
|
|
POL
GTKALTEVIPL
474
11
11
17
4783
|
|
POL
DIVPLTEEAEL
480
11
13
20
4784
|
|
POL
EVIPLTEEAEL
480
11
11
17
4785
|
|
POL
ELELAENREIL
489
11
53
83
4786
|
|
POL
EILKEPVIIGVY
497
11
40
63
4787
|
|
POL
ILKEPVIIGVYY
498
11
38
59
4788
|
|
POL
GVYYDPSKDLI
508
11
31
48
4789
|
|
POL
QWTYQIYQEP
528
11
42
66
4790
|
|
POL
SIVIWGKTPKF
571
11
41
64
4791
|
|
POL
VIWGKTPKFK
573
11
17
27
4792
|
|
POL
VIWGKTPKPR
573
11
29
45
4793
|
|
POL
KFKLPIQKETW
580
11
20
31
4794
|
|
POL
KFRLPIQKETW
580
11
26
41
4795
|
|
POL
PIQKETWEAW
584
11
15
23
4796
|
|
POL
PIQKETWETW
584
11
27
42
4797
|
|
POL
ETWETWWTD
588
11
10
16
4798
|
|
POL
TWWTDYWQA
592
11
10
16
4799
|
|
POL
TWWTEYWQA
592
11
12
19
4800
|
|
POL
WWTDYWQAT
593
11
14
22
4801
|
|
POL
WWTEYWQAT
593
11
23
36
4802
|
|
POL
DYWQATWIPE
596
11
19
30
4803
|
|
POL
EYWQATWIPE
596
11
33
52
4804
|
|
POL
EFVNTPPLVKL
607
11
54
84
4805
|
|
POL
FVNTPPLVKL
608
11
54
86
4806
|
|
POL
KLWYQLEKDPI
616
11
14
22
4807
|
|
POL
KLWYQLEKEPI
616
11
31
48
4808
|
|
POL
KLWYQLETEPI
616
11
11
17
4809
|
|
POL
LTDTTNQKTE
661
11
19
30
4810
|
|
POL
LTETTNQKTE
661
11
25
39
4811
|
|
POL
TTNQKTELIIAI
664
11
12
19
4812
|
|
POL
TTNQKTELQAI
664
11
42
66
4813
|
|
POL
KTELQAIIILAL
668
11
15
23
4814
|
|
POL
KTELQAIYLAL
668
11
12
19
4815
|
|
POL
AIIILALQDSGL
673
11
15
23
4816
|
|
POL
ALQDSGLEVNI
677
11
27
42
4817
|
|
POL
ALQDSGSEVNI
677
11
25
39
4818
|
|
POL
IVTDSQYALGI
687
11
58
91
4819
|
|
POL
VTDSQYALGII
688
11
58
91
4820
|
|
POL
ELVNQIIEQLI
708
11
18
28
4821
|
|
POL
ELVSQIIEQLI
708
11
19
30
4822
|
|
POL
LIKKIEKVYLA
717
11
20
31
4823
|
|
POL
LIKKEKVYLSW
717
11
3
20
4824
|
|
POL
YLAWVPAIIKG
724
11
22
34
4825
|
|
POL
YLSWVPAIIKG
724
11
37
58
4826
|
|
POL
GIGGNCQVDKL
733
11
58
91
4827
|
|
POL
KLVSAGIRKVL
742
11
15
23
4828
|
|
POL
KLVSSGIRKVL
742
11
26
41
4829
|
|
POL
LVSAGIRKVLF
743
11
15
23
4830
|
|
POL
LVSSGIRKVLF
743
11
26
41
4831
|
|
POL
IRKVLFLDGI
747
11
49
77
4832
|
|
POL
NWRAMASDF
770
11
41
64
4833
|
|
POL
AMASDFNLPPI
773
11
18
28
4834
|
|
POL
EIVASCDKCQL
787
11
43
67
4835
|
|
POL
QVDCSPGIWQ
805
11
56
88
4836
|
|
POL
QLDCTIILEGKI
814
11
33
52
4837
|
|
POL
ILVAVHVASGY
825
11
53
83
4838
|
|
POL
LYAVIIVASGYI
826
11
47
73
4839
|
|
POL
ETGQETAYFIL
844
11
31
48
4840
|
|
POL
ETGQETAYFLL
844
11
26
41
4841
|
|
POL
AYFILKLAGR
850
11
31
48
4842
|
|
POL
AYFLLKLAGR
850
11
25
39
4843
|
|
POL
KLAGRWPVKT
855
11
13
20
4844
|
|
POL
KLAGRWPVKV
855
11
22
34
4845
|
|
POL
KVIIITDNGSNF
863
11
21
33
4846
|
|
POL
FTSAAVKAAC
873
11
27
42
4847
|
|
POL
FTSTTVKAAC
873
11
14
22
4848
|
|
POL
AVKAACWWA
877
11
10
16
4849
|
|
POL
TVKAACWWA
877
11
20
31
4850
|
|
POL
WWAGIKQEFG
883
11
21
33
4851
|
|
POL
WWAGIQQEFG
883
11
11
17
4852
|
|
POL
HLKTAVQMAV
923
11
57
89
4853
|
|
POL
AVQMAVFIHN
927
11
60
94
4854
|
|
POL
FIHNFKRKGGI
933
11
58
91
4855
|
|
POL
NFKRKGGIGGY
936
11
59
92
4856
|
|
POL
GIGGYSAGERI
942
11
57
89
4857
|
|
POL
GYSAGERIIDI
945
11
40
63
4858
|
|
POL
GYSAGERIVDI
945
11
14
22
4859
|
|
POL
IIASDIQTKEL
955
11
14
22
4860
|
|
POL
IIATDIQTKEL
955
11
34
53
4861
|
|
POL
DIQTKELQKQI
959
11
44
69
4862
|
|
POL
QIIKIQNFRVY
968
11
12
19
4863
|
|
POL
QITKIQNFRVY
968
11
35
55
4864
|
|
POL
IIKIQNFRVYY
969
11
12
19
4865
|
|
POL
ITKIQNFRVYY
969
11
36
57
4866
|
|
POL
RVYYRDSRDPI
976
11
34
53
4867
|
|
POL
RVYYRDSRDP
976
11
14
22
4868
|
|
POL
VYYRDSRDPI
977
11
34
53
4869
|
|
POL
VYYRDSRDPL
977
11
14
22
4870
|
|
POL
PIWKGPAKLL
985
11
35
55
4871
|
|
POL
PLWKGPAKLL
985
11
18
28
4872
|
|
POL
LLWKGEGAVV
993
11
59
92
4873
|
|
POL
KVVPRRKAKII
1011
11
50
78
4874
|
|
POL
KVVPRRKVKII
1011
11
11
17
4875
|
|
REV
LLKTVRLI
12
8
11
17
4876
|
|
REV
AVRIIKIL
17
8
13
20
4877
|
|
REV
ILYQSNPY
23
8
27
42
4878
|
|
REV
QLPPIERL
78
8
14
22
4879
|
|
REV
QLPPLERL
78
8
37
58
4880
|
|
REV
LVESPAVL
114
8
11
17
4881
|
|
REV
AVRIIKILY
17
9
13
20
4882
|
|
REV
KILYQSNPY
22
9
26
41
4883
|
|
REV
RWRARQRQI
48
9
35
55
4884
|
|
REV
RWRERQRQI
48
9
11
17
4885
|
|
REV
PVPLQLPPI
74
9
11
17
4886
|
|
REV
PVPLQLPPL
74
9
35
55
4887
|
|
REV
PLQLPPIERL
76
10
11
17
4888
|
|
REV
PLQLPPLERL
76
10
34
53
4889
|
|
REV
QLPPLERLTL
78
10
18
28
4890
|
|
REV
GTQGVGSPQI
97
10
11
18
4891
|
|
REV
IIKILYQSNPY
20
11
18
28
4892
|
|
TAT
CYCKKCCF
28
8
11
17
4893
|
|
TAT
CYCKKCCY
28
8
11
17
4894
|
|
TAT
CFIICQVCF
34
8
11
17
4895
|
|
TAT
FLNKGLGI
41
8
14
22
4896
|
|
TAT
PVDPNLEPW
3
9
20
31
4897
|
|
TAT
PVDPRLEPW
3
9
14
22
4898
|
|
TAT
CFLNKGLGI
40
9
14
22
4899
|
|
TAT
FLNKGLGISY
41
10
14
22
4900
|
|
TAT
CFLNKGLGISY
40
11
14
22
4901
|
|
VIP
RWQVLIVW
4
8
10
16
4902
|
|
VIP
RWQVMIVW
4
8
43
67
4903
|
|
VIP
IVWQVDRM
9
8
59
92
4904
|
|
VIP
KIRTWNSL
17
8
12
19
4905
|
|
VIP
RIRTWKSL
17
8
15
23
4906
|
|
VIP
RIRTWNSL
17
8
15
23
4907
|
|
VIP
SLYKIIIIMY
23
8
44
69
4908
|
|
VIP
LVKIIIIMYI
24
8
19
30
4909
|
|
VIP
GWPYRIIIIY
37
8
20
31
4910
|
|
VIP
KISSEVIII
50
8
15
23
4911
|
|
VIP
KVSSIEVIII
50
8
20
31
4912
|
|
VIP
RISSEVIII
50
8
15
23
4913
|
|
VIP
RLVITTYW
65
8
12
19
4914
|
|
VIP
VIKTYWGL
67
8
10
16
4915
|
|
VIP
VIITYWGL
67
8
22
34
4916
|
|
VIP
VVRTYWGL
67
8
10
16
4917
|
|
VIP
VVYIYWGL
67
8
11
17
4918
|
|
VIP
IILGIIGVSI
83
8
25
39
4919
|
|
VIP
IILCAQGVSI
83
8
26
41
4920
|
|
VIP
GVSIEWRL
87
8
18
28
4921
|
|
VIP
STQIDPDL
100
8
12
19
4922
|
|
VIP
STQVDPGL
100
8
11
11
4923
|
|
VIP
QLIIILYYP
110
8
14
22
4924
|
|
VIP
QLIIIMIIYF
110
8
14
22
4925
|
|
VIP
IILYYPDCP
113
8
16
25
4926
|
|
VIP
IIMIIYPDCP
113
8
15
23
4927
|
|
VIP
IVSPRCEY
133
8
14
22
4928
|
|
VIP
KVGSLQYL
146
8
52
81
4929
|
|
VIP
QYLALAAL
151
8
12
19
4930
|
|
VIP
QYLALKAL
151
8
11
17
4931
|
|
VIP
QYLALTAL
151
8
33
52
4932
|
|
VIP
YLALTALI
152
8
28
44
4933
|
|
VIP
ALIKPKKI
157
8
10
16
4934
|
|
VIP
PLPSVKKL
168
8
21
33
4935
|
|
VIP
PLPSVRKL
168
8
14
22
4936
|
|
VIP
MIVWQVDRM
8
9
46
72
4937
|
|
VIP
VWQVDRMKI
10
9
13
20
4938
|
|
VIP
VWQVDRMRI
10
9
48
75
4939
|
|
VIP
SLYKIIIIMYI
23
9
19
30
4940
|
|
VIP
IIIPLGDARL
56
9
13
20
4941
|
|
VIP
IIIPLGEARL
56
9
20
31
4942
|
|
VIP
PLGEARLVI
58
9
10
16
4943
|
|
VIP
LVIKTYWGL
66
9
10
16
4944
|
|
VIP
LVITTYWGL
66
9
22
34
4945
|
|
VIP
GLIITGERDW
73
9
22
34
4946
|
|
VIP
GLQTGERDW
73
9
12
19
4947
|
|
VIP
IITGERDWIIL
75
9
21
33
4948
|
|
VIP
QTGERDWIIL
75
9
12
19
4949
|
|
VIP
SIEWRLRRY
89
9
11
17
4950
|
|
VIP
DLADQLIIIL
106
9
18
28
4951
|
|
VIP
GLADQLIIIM
106
9
15
23
4952
|
|
VIP
QYLALTALI
151
9
28
44
4953
|
|
VIP
VMIVWQVDR
7
10
44
69
4954
|
|
VIP
IVWQVDRMKI
9
10
12
19
4955
|
|
VIP
IVWQVDRMRI
9
10
47
73
4956
|
|
VIP
QVDRMKIRTW
12
10
12
19
4957
|
|
VIP
QVDRMRINTW
12
10
10
16
4958
|
|
VIP
QVDRMRIRTW
12
10
31
48
4959
|
|
VIP
RMKIRTWNSL
15
10
12
19
4960
|
|
VIP
RMRIRTWKSL
15
10
15
23
4961
|
|
VIP
RMRIRTWNSL
15
10
15
23
4962
|
|
VIP
TWKSLVKIIII
20
10
16
25
4963
|
|
VIP
TWNSLVKIIII
20
10
25
39
4964
|
|
VIP
KISSEVHIPL
50
10
14
22
4965
|
|
VIP
KVSSEVHIPL
50
10
19
30
4966
|
|
VIP
RISSEVIIIPL
50
10
13
20
4967
|
|
VIP
RLVITTYWGL
65
10
12
19
4968
|
|
VIP
DWHLGIIGVSI
81
10
21
33
4969
|
|
VIP
DWHLGQGVSI
81
10
18
28
4970
|
|
VIP
IILGIIGYSIEW
83
10
25
39
4971
|
|
VIP
IILGQGVSIEW
83
10
26
41
4972
|
|
VIP
RYSIQVDPGL
98
10
10
16
4973
|
|
VIP
QIDPDLADQL
102
10
10
16
4974
|
|
VIP
QVDPGLADQL
102
10
14
22
4975
|
|
VIP
LIIILYYPDCF
111
10
16
25
4976
|
|
VIP
LIIIMIIYPDCF
111
10
15
23
4977
|
|
VIP
YFDCPSESAI
116
10
28
44
4978
|
|
VIP
KVGSLQYLAL
146
10
51
80
4979
|
|
VIP
SLQYLALAAL
149
10
12
19
4980
|
|
VIP
SLQYLALKAL
149
10
11
17
4981
|
|
VIP
SLQYLALTAL
149
10
31
48
4982
|
|
VIP
SVKKLTEDRW
174
10
13
20
4983
|
|
VIP
QVMIVWQVDR
6
11
43
67
4984
|
|
VIP
MIVWQVDRM
8
11
43
67
4985
|
|
VIP
RTWKSLVKIIII
19
11
14
22
4986
|
|
VIP
RIWNSLVKIIII
19
11
24
38
4987
|
|
VIP
TWKSLVKIIII
20
11
16
25
4988
|
|
VIP
TWNSLVKIIII
20
11
22
34
4989
|
|
VIP
EVIIIPLGDARL
54
11
13
20
4990
|
|
VIP
EVIIIPLGEARL
54
11
20
31
4991
|
|
VIP
IIIPLGEARLVI
56
11
10
16
4992
|
|
VIP
YWGLIITGERD
71
11
22
34
4993
|
|
VIP
YWGLQTGERD
71
11
12
19
4994
|
|
VIP
GLIITGERDWH
73
11
21
33
4995
|
|
VIP
GLQTGERDWH
73
11
12
19
4996
|
|
VIP
GVSIEWRLRR
87
11
10
16
4997
|
|
VIP
QIDPDLADQLI
102
11
10
16
4998
|
|
VIP
QVDPGLADQLI
102
11
14
22
4999
|
|
VIP
GLADQLIIIMH
106
11
11
17
5000
|
|
VIP
QLIIILYYPDCF
110
11
13
20
5001
|
|
VIP
QLIIIMHYPDCP
110
11
14
22
5002
|
|
VIP
YYPDCFSESAI
115
11
20
31
5003
|
|
VIP
CFSDSAIRKAI
119
11
10
16
5004
|
|
VIP
CPSESAIRKAI
119
11
12
19
5005
|
|
VIP
CPSESAIRNAI
119
11
12
19
5006
|
|
VIP
SLQYLALTALI
149
11
27
42
5007
|
|
VIP
LIKPKKIKPPL
158
11
10
16
5008
|
|
VIP
KTKGIIRGSIIT
188
11
15
23
5009
|
|
VPR
ALELLEEL
19
8
10
16
5010
|
|
VPR
TLELLEEL
19
8
44
69
5011
|
|
VPR
AVRIIFPRI
30
8
14
22
5012
|
|
VPR
WLIIGLGQY
38
8
11
17
5013
|
|
VPR
TWAGVEAI
53
8
16
25
5014
|
|
VPR
TWEGVEAI
53
8
20
31
5015
|
|
VPR
GVEAIIRI
56
8
34
53
5016
|
|
VPR
IIRILQQL
60
8
42
66
5017
|
|
VPR
RILQQLLP
62
8
45
70
5018
|
|
VPR
ILQQLLFI
63
8
37
58
5019
|
|
VPR
LLFIIIFRI
67
8
44
69
5020
|
|
VPR
LLFVIIPRI
67
8
12
19
5021
|
|
VPR
PYNLWILEL
14
9
3)1
47
0.1400
5022
|
|
VPR
WTLELLEEL
18
9
42
69
5023
|
|
VPR
AVRIIFPRIW
30
9
14
22
5024
|
|
VPR
AVRIIFPRPW
30
9
34
53
5025
|
|
VPR
PWLIIGLGQY
37
9
11
17
5026
|
|
VPR
WLIIGLGQIII
38
9
20
31
5027
|
|
VPR
IYETYGDTW
46
9
31
48
0.0580
5028
|
|
VPR
IYNTYGDTW
46
9
18
28
5029
|
|
VPR
DTWAGVEAI
52
9
16
25
5030
|
|
VPR
DTWEGVEAI
52
9
20
31
5031
|
|
VPR
TWAGVEAII
53
9
16
25
5032
|
|
VPR
TWEGVEAII
53
9
19
30
5033
|
|
VPR
GVEAIIRIL
56
9
34
53
5034
|
|
VPR
AIIRILQQL
59
9
39
61
5035
|
|
VPR
IIRILQQLL
60
9
42
66
5036
|
|
VPR
RILQQLLFI
62
9
36
56
5037
|
|
VPR
QLLFIIIPRI
66
9
44
69
5038
|
|
VPR
QLLFVIIFRI
66
9
10
16
5039
|
|
VPR
RIGCQIISRI
74
9
47
73
5040
|
|
VPR
RIGCRIISRI
74
9
12
19
5041
|
|
VPR
PYNEFTLELL
14
10
30
47
5042
|
|
VPR
EWTLELLEEL
17
10
40
63
5043
|
|
VPR
ELKNEAVRHP
25
10
17
27
5044
|
|
VPR
ELKSEAVRHF
25
10
15
23
5045
|
|
VPR
AVRIIFPRIWL
30
10
14
22
5046
|
|
VPR
AVRIIFPRPWL
30
10
34
53
5047
|
|
VPR
HFPRIWLHSL
33
10
10
16
5048
|
|
VPR
HFPRPWLHGL
33
10
24
38
5049
|
|
VPR
PWLIIGLGQHI
37
10
12
19
5050
|
|
VPR
WLHGLGQIIIY
38
10
20
31
5051
|
|
VPR
HIYETYCDTW
45
10
17
27
5052
|
|
VPR
HIYNTYGDTW
45
10
14
22
5053
|
|
VPR
YIYETYGDTW
45
10
14
22
5054
|
|
VPR
DTWAGVEAII
52
10
16
25
5055
|
|
VPR
DTWEGVEAII
52
10
19
30
5056
|
|
VPR
AIIRILQQLL
59
10
39
61
5057
|
|
VPR
IIRILQQLLF
60
10
41
64
5058
|
|
VPR
ILQQLLFIIIF
63
10
35
55
5059
|
|
VPR
PWLHCLGQHI
37
11
12
19
5060
|
|
VPR
QYIYETYGDT
44
11
14
22
5061
|
|
VPR
TWAGVEAIIRI
53
11
15
23
5062
|
|
VPR
TWEGVEAIIRI
53
11
14
22
5063
|
|
VPR
AIIRILQQLLF
59
11
38
59
5064
|
|
VPR
IIRILQQLLFI
60
11
33
52
5065
|
|
VPR
RILQQLLFIIIF
62
11
34
53
5066
|
|
VPR
IIFRIGCQIISRI
71
11
44
69
5067
|
|
VPR
HFRIGCRIISRI
71
11
11
17
5068
|
|
VPR
RIGCQIISRIGI
74
11
45
70
5069
|
|
VPR
RIGCRIISRIGI
74
11
11
17
5070
|
|
VPU
KVDYRIVI
7
8
01
33
5071
|
|
VPU
LIIAIVVW
26
8
10
16
5072
|
|
VPU
IVVWTIVF
30
8
15
23
5073
|
|
VPU
VVWTIVFI
31
8
15
23
5074
|
|
VPU
WTIVFIEY
34
8
12
19
5075
|
|
VPU
VFIEYRKI
37
8
12
19
5076
|
|
VPU
KILRQRKI
45
8
15
23
5077
|
|
VPU
EMGIIIIAPW
89
8
11
17
5078
|
|
VPU
NYELAYGAL
5
9
01
25
5079
|
|
VPU
DYKLGVGAL
10
9
02
29
5080
|
|
VPU
DYRLGVGAL
10
9
03
43
5081
|
|
VPU
IIAIVVWTI
27
9
23
36
5082
|
|
VPU
AIVVWTIVF
29
9
14
22
5083
|
|
VPU
IVVWTIVFI
30
9
15
23
5084
|
|
VPU
VWTIVFIEY
33
9
12
19
5085
|
|
VPU
IVFIEYRKI
36
9
12
19
5086
|
|
VPU
KIDRLIDRI
52
9
14
22
5087
|
|
VPU
VTLLSSSKL
94
9
01
50
5088
|
|
VPU
NYELAVGALI
5
10
01
25
5089
|
|
VPU
DYKLGVGALI
10
10
02
29
5090
|
|
VPU
DYRLGVGALI
10
10
03
43
5091
|
|
VPU
AIVVWTIVFI
29
10
14
22
5092
|
|
VPU
VVWTIVFIEY
31
10
12
19
5093
|
|
VPU
ILRQRKIDRL
46
10
15
23
5094
|
|
VPU
GVEMGIIIIAP
91
10
01
511
5095
|
|
VPU
LVTLLSSSKL
91
10
01
511
5096
|
|
VPU
KYDYRIVIVAF
7
11
01
33
5097
|
|
VPU
KVDYRLGVGA
7
11
01
33
5098
|
|
VPU
RIDYRLGVGAL
7
11
01
33
5099
|
|
VPU
IVVWTIVFIEY
30
11
12
19
5100
|
|
VPU
EYRKILRQRKI
41
11
13
21
5101
|
|
VPU
KILRQRKIDRL
45
11
15
23
5102
|
|
VPU
ILRQRKIDRLI
46
11
13
20
5103
|
|
VPU
RIKEIRDDSDY
64
11
01
50
5104
|
|
VPU
RIREIRDDSDY
64
11
01
50
5105
|
|
TABLE XI
|
|
|
HIV B07 Super Motif Peptides with Binding Information
|
No. of
Sequence
Conservancy
|
Protein
Sequence
Position
Amino Acids
Frequency
(%)
B*0702
SEQ ID NO.
|
|
ENV
DPNPQEVV
91
8
13
20
5106
|
|
ENV
APAGFAIL
265
8
29
45
5107
|
|
ENV
KPVVSTQL
299
8
34
53
5108
|
|
ENV
RPVVSTQL
299
8
26
41
5109
|
|
ENV
GPCGQTFYA
362
8
11
17
5110
|
|
ENV
LPCRIKQI
485
8
31
48
5111
|
|
ENV
SPLSFQTL
808
8
30
47
5112
|
|
ENV
GPDRPEGI
822
8
15
23
5113
|
|
ENV
EPDRPERI
823
8
01
33
5114
|
|
ENV
PPDRPLGI
823
8
01
33
5115
|
|
ENV
DPNPQEVVL
91
9
12
19
0.0002
5116
|
|
ENV
KPCVKLTPL
130
9
55
86
0.4100
5117
|
|
ENV
CPKVSFEPI
250
9
30
47
0.0550
5118
|
|
ENV
DPIPIIIYCA
256
9
12
19
5119
|
|
ENV
EPIPIIIYCA
256
9
26
41
0.0001
5120
|
|
ENV
IPIIIYCAPA
259
9
36
56
0.0130
5121
|
|
ENV
IPIIIYCTPA
259
9
18
28
5122
|
|
ENV
GPCKNVSTV
283
9
15
23
5123
|
|
ENV
GPCTNVSTV
283
9
11
17
0.0019
5124
|
|
ENV
KPVVSTQLL
299
9
34
53
0.0012
5125
|
|
ENV
RPVVSTQLL
299
9
26
41
0.0084
5126
|
|
ENV
DPEIVMIISF
428
9
14
22
0.0001
5127
|
|
ENV
LPCRIKQII
485
9
20
31
0.0011
5128
|
|
ENV
LPCRIKQIV
485
9
10
16
5129
|
|
ENV
APTKAKRRV
575
9
22
34
0.0082
5130
|
|
ENV
SPLSFQTLL
808
9
10
16
5131
|
|
ENV
IPRRIRQGF
950
9
10
16
5132
|
|
ENV
IPRRIRQGL
950
9
24
38
5133
|
|
ENV
IPTRIRQGL
950
9
11
17
5134
|
|
ENV
VPTDPNPQEI
88
10
25
39
5135
|
|
ENV
VPIDPNPQEV
88
10
21
33
0.0008
5136
|
|
ENV
KPVVSTQLLL
299
10
34
53
5137
|
|
ENV
RPVVSTQLLL
299
10
26
41
0.0038
5138
|
|
ENV
RPNNNTRKSI
347
0
17
27
5139
|
|
ENV
EPLGVAPTKA
570
10
21
33
0.0005
5140
|
|
ENV
APTKAKRRVV
575
10
22
34
0.1200
5141
|
|
ENV
VPVWKEATTT
53
11
22
34
0.0022
5142
|
|
ENV
VPIDPNPQEV
88
11
13
20
5143
|
|
ENV
KPCVKLTPLC
130
11
54
84
0.0004
5144
|
|
ENV
CPKVSFEPIPI
250
11
30
47
5145
|
|
ENV
DPIPIHYCAPA
256
11
10
16
5146
|
|
ENV
EPIPIHYCAPA
256
11
24
38
5147
|
|
ENV
EPIPIIIYCTPA
256
11
10
16
5148
|
|
ENV
IPIHYCAPAGF
239
11
26
41
5149
|
|
ENV
IPIHYCTPAGF
259
11
10
16
5150
|
|
ENV
LPCRIKQIINM
485
11
18
28
5151
|
|
ENV
RPGGGDMRDN
547
11
38
59
5152
|
|
GAG
RPGGKKKY
22
8
35
55
5153
|
|
GAG
NTGLLETA
49
8
15
23
5154
|
|
GAG
SPRTLNAW
169
8
57
89
0.0036
5155
|
|
GAG
SPEVIPMF
186
8
55
86
0.0012
5156
|
|
GAG
TPQDLNMM
201
8
12
19
5157
|
|
GAG
TPQDLNTM
201
8
42
66
0.0001
5158
|
|
GAG
HPVIIAGPI
237
8
38
59
0.0012
5159
|
|
GAG
GPIAPGQM
242
8
19
30
0.0005
5160
|
|
GAG
GPIPPGQM
242
8
17
27
5161
|
|
GAG
GPVAPGQM
242
8
10
16
5162
|
|
GAG
EPRGSDIA
251
8
56
88
0.0001
5163
|
|
GAG
PPIPVGDI
278
8
10
16
5164
|
|
GAG
PPIPVGEI
278
8
35
55
0.0001
5165
|
|
GAG
SPTSILDI
302
8
13
20
5166
|
|
GAG
SPVSILDI
302
8
40
63
5167
|
|
GAG
NPDCKSIL
351
8
11
17
5168
|
|
GAG
NPDCKTIL
351
8
46
72
0.0003
5169
|
|
GAG
GPGIIKARV
379
8
36
56
0.0002
5170
|
|
GAG
GPSIIKARV
379
8
19
30
5171
|
|
GAG
APRKKGCW
440
8
55
86
0.0004
5172
|
|
GAG
PPAESFGF
498
8
10
16
5173
|
|
GAG
PPEESFRF
498
8
15
23
5174
|
|
GAG
PPAESFRF
510
8
02
67
5175
|
|
GAG
PPPESFRF
510
8
01
33
5176
|
|
GAG
EPIDKELY
533
8
12
19
5177
|
|
GAG
EPIDKELY
537
8
01
25
5178
|
|
GAG
SPRTLNAWV
169
9
57
89
0.5500
5179
|
|
GAG
TPQDLNMML
201
9
12
19
5180
|
|
GAG
TPQDLNTML
201
9
42
66
0.0008
5181
|
|
GAG
IIPVIIAGPIA
237
9
19
30
0.0590
5182
|
|
GAG
NPPIPVGDI
277
9
10
16
5183
|
|
GAG
NPPIPVGEI
277
9
34
54
0.0002
5184
|
|
GAG
PPIPVGDIY
278
9
10
16
5185
|
|
GAG
PPIPVGEIY
278
9
35
55
0.0002
5186
|
|
GAG
GPKEPFRDY
312
9
63
98
0.0002
5187
|
|
GAG
GPAATLEEM
362
9
16
25
0.0014
5188
|
|
GAG
GPGATLEEM
362
9
18
28
5189
|
|
GAG
GPGHKARVL
379
9
35
55
0.0290
5190
|
|
GAG
GPSHKARVL
379
9
19
30
5191
|
|
GAG
RPEPTAPPA
490
9
30
47
0.0014
5192
|
|
GAG
APPAESFGF
497
9
10
16
5193
|
|
GAG
APPEESFRF
497
9
15
23
0.0046
5194
|
|
GAG
RPEPTAPPA
504
9
01
50
0.0014
5195
|
|
GAG
APPAESFRF
509
9
02
67
5196
|
|
GAG
APPPESFRF
509
9
01
33
5197
|
|
GAG
TPSQKQEPI
527
9
10
17
5(98
|
|
GAG
YPLASLKSL
545
9
08
17
5199
|
|
GAG
YPLASLRSL
545
9
07
15
0.9900
5200
|
|
GAG
PPLASLKSL
546
9
04
24
5201
|
|
GAG
EPLTALRSL
547
9
01
33
5202
|
|
GAG
PPLASLKSL
547
9
01
33
5203
|
|
GAG
PPLISLKSL
547
9
01
33
5204
|
|
GAG
RPGGKKKYKL
22
10
10
16
5205
|
|
GAG
RPGGKKKYRL
22
10
16
25
5206
|
|
GAG
SPEVIPMFSA
186
10
41
64
0.0002
5207
|
|
GAG
SPEVIPMFTA
186
10
13
20
5208
|
|
GAG
NPPIPVGDIY
277
10
10
16
5209
|
|
GAG
NPPIPVGEIY
277
10
34
54
0.0002
5210
|
|
GAG
IPVGDIYKRW
280
10
11
17
5211
|
|
GAG
IPVGEIYKRW
280
10
34
53
0.0002
5212
|
|
GAG
GPKEPFRDYV
312
10
63
98
0.0002
5213
|
|
GAG
EPFRDYVDRP
315
10
63
98
0.00012
5214
|
|
GAG
NPDCKTILKA
351
10
28
44
0.0002
5215
|
|
GAG
NPDCKTILRA
351
10
18
28
5216
|
|
GAG
GPAATLEEMM
362
10
16
25
0.0020
5217
|
|
GAG
GPGATLEEMM
362
10
18
28
5218
|
|
GAG
GPGIIKARVLA
379
10
35
55
0.0002
5219
|
|
GAG
GPSIIKARVLA
379
10
19
30
5220
|
|
GAG
PPAEPTAPPA
491
10
01
50
5221
|
|
GAG
EPTAPPACSF
494
10
20
31
5222
|
|
GAG
EPTAPPEESF
494
10
15
23
0.0002
5223
|
|
GAG
EPTAPPAESF
506
10
01
50
5224
|
|
GAG
EPIAPPPESF
506
10
01
50
5225
|
|
GAG
PPESFRFEEA
511
10
01
33
5226
|
|
GAG
EPIDKELYPL
533
10
12
19
0.0029
5227
|
|
GAG
EPIDKELYPL
537
10
01
25
0.0019
5228
|
|
GAG
YPLASIKSLF
545
10
08
17
5229
|
|
GAG
YPLASLRSLF
545
10
07
15
0.0140
5230
|
|
GAG
PPLASLKSLP
546
10
04
24
5231
|
|
GAG
EPLTALRSLF
547
10
01
33
5232
|
|
GAG
PPLASLKSLF
547
10
01
33
5233
|
|
GAG
PPLISLKSLF
547
10
01
33
5234
|
|
GAG
QPSLQTGSEEL
67
11
13
20
5235
|
|
GAG
YPIVQNAQGQ
253
11
20
31
5236
|
|
GAG
YPIVQNLQGQ
153
11
29
45
5237
|
|
GAG
SPRTLNAWYK
169
11
55
86
0.0076
5238
|
|
GAG
SPEVIPMFSAL
186
11
41
64
0.0003
5239
|
|
GAG
SPEVIPMFTAL
186
11
13
20
5240)
|
|
GAG
IPMFSALSIEGA
190
11
45
70
0.0004
5241
|
|
GAG
IPMFTALSEGA
290
11
15
23
5242
|
|
GAG
TPQDLNMMLN
201
11
11
17
5243
|
|
GAG
IPVGDIYKRWI
280
11
10
16
5244
|
|
GAG
IPVGEIYKRWI
280
11
34
53
0.0001
5245
|
|
GAG
EPFRDYVDRFF
325
11
35
55
5246
|
|
GAG
EPFREYVIIRF
325
11
28
44
0.0001
5247
|
|
GAG
NPDCKTILKAL
352
11
28
44
0.0001
5248
|
|
GAG
NPDCKTILRAL
352
11
28
28
5249
|
|
GAG
WPSHKGRPGN
474
11
23
36
5250
|
|
GAG
WPSNKGRPGN
474
11
24
22
5251
|
|
GAG
WPSSKGRPGN
474
11
11
17
5252
|
|
GAG
PPPESFRFEEA
520
11
02
33
5253
|
|
NEF
APTAAKGV
34
8
01
33
5254
|
|
NEF
VPLRPMTF
101
8
20
16
5255
|
|
NEF
VPLRPMTY
101
8
46
73
0.0001
5256
|
|
NEF
RPMTYKAA
104
8
23
36
5257
|
|
NEF
RPMTYKGA
104
8
25
39
5258
|
|
NEF
TPGPGIRY
208
8
17
27
5259
|
|
NEF
TPGPGTRF
208
8
13
20
5260
|
|
NEF
GPGIRYPL
210
8
17
27
5261
|
|
NEF
GPGTRFPL
210
8
13
20
5262
|
|
NEF
VPVD)PREV
230
8
11
17
5263
|
|
NEF
IIPICQIIGM
259
8
10)
16
5264
|
|
NEF
IIPMSQIIGM
259
8
12
19
5265
|
|
NEF
EPAADGVGA
40
9
05
19
0.0001
5266
|
|
NEF
PPAAEGVGA
40
9
04
IS
5267
|
|
NEF
FPVRPQVPL
94
9
48
75
0.7600
5268
|
|
NEF
RPQVPLRPM
98
9
47
73
1.7000
5269
|
|
NEF
RPMTYKGAF
104
9
12
19
5270
|
|
NEF
FPLTFGWCF
217
9
17
27
5271
|
|
NEF
YPLTFGWCF
217
9
24
38
5272
|
|
NEF
APTAAKGVGA
34
10
01
33
5273
|
|
NEF
IEPAADGVGAV
40
10
04
15
5274
|
|
NEF
VPLRPMTYKA
101
10
20
32
0.0001
5275
|
|
NEF
TPGPGIRYPL
208
10
16
25
5276
|
|
NEF
TPGPGTRFPL
208
10
13
20
5277
|
|
NEF
GPGIRYPLTF
210
10
13
20
5278
|
|
NEF
GPGIRFPLTF
210
10
13
20
5279
|
|
NEF
APTAAKGVGA
34
11
01
33
5280
|
|
NEF
RPQVPLRPMT
98
11
10
16
5281
|
|
NEF
RPQVPLRPMT
98
11
36
56
5282
|
|
NEF
VPLRPMTYKA
101
11
19
30
5283
|
|
NEF
VPLRPMTYKG
101
11
23
37
5284
|
|
NEF
RPMTYKGAFD
104
11
12
19
5285
|
|
NEF
FPLTFGWCFK
217
11
17
27
5286
|
|
NEF
YPLTFGWCFK
217
11
20
31
5287
|
|
POL
EPGEDREL
69
8
01
17
5288
|
|
POL
GPERALSV
70
8
01
20
5289
|
|
POL
RPLVTIKI
95
8
14
22
5290
|
|
POL
RPLVTVKI
95
8
12
19
5291
|
|
POL
KPKMIGGI
130
8
60
94
0.0023
5292
|
|
POL
GPTPVNII
165
8
54
84
0.0001
5293
|
|
POL
SPIETVPV
189
8
56
88
0.0021
5294
|
|
POL
WPLTEEKI
211
8
56
88
0.0001
5295
|
|
POL
NPYNTPIF
243
8
24
38
5296
|
|
POL
NPYNTPVF
243
8
38
59
0.0008
5297
|
|
POL
TPGIRYQY
328
8
52
81
0.0001
5298
|
|
POL
PPFLWMGY
414
8
64
100
0.0001
5299
|
|
POL
EPVIIGVYY
504
8
41
64
0.0001
5S300
|
|
POL
DPSKDLIA
512
8
34
53
5301
|
|
POL
TPKFKLPI
S78
8
17
27
5302
|
|
POL
TPKFRLPI
578
8
30
47
5303
|
|
POL
LPIQKETW
583
8
47
73
0.0001
5304
|
|
POL
TPPLVKLW
611
8
57
89
0.0001
5305
|
|
POL
PPLVKLWY
612
8
57
89
0.0001
5306
|
|
POL
PPIVAKEI
781
8
27
42
5307
|
|
POL
PPVVAKEI
781
8
29
45
0.0001
5308
|
|
POL
NPQSQGVV
896
8
59
92
0.0001
5309
|
|
POL
DPIWKGPA
984
8
37
58
5310
|
|
POL
DPLWKGPA
984
8
15
23
5311
|
|
POL
VPRRKAKI
1013
8
51
80
0.0018
5312
|
|
POL
VPRRKVKI
1013
8
11
17
5313
|
|
POL
FPQGEAREF
8
9
10
16
5314
|
|
POL
SPTRRELQV
29
9
14
22
0.0210
5315
|
|
POL
SPTSRELQV
35
9
01
33
5316
|
|
POL
SPSSRELQV
38
9
01
50
5317
|
|
POL
VPTNFPQI
79
9
01
17
5318
|
|
POL
LPGKWKPKM
125
9
39
61
5319
|
|
POL
LPGRWKPKM
125
9
16
25
0.0038
5320
|
|
POL
FPISPIETV
186
9
56
88
0.0016
5321
|
|
POL
VPVKLKPGM
194
9
56
88
0.0003
5322
|
|
POL
KPGMDGPKV
199
9
51
80
0.0002
5323
|
|
POL
GPKVKQWPL
205
9
51
80
0.0150
5324
|
|
POL
NPYNTPIFA
243
9
24
38
5325
|
|
POL
NPYNTPVFA
243
9
37
58
0.0002
5326
|
|
POL
SPAIFQSSM
345
9
42
66
0.4100
5327
|
|
POL
NPDIVIYQY
364
9
17
27
0.0001
5328
|
|
POL
NPEIVIYQY
364
9
23
36
5329
|
|
POL
EPPFLWMGY
413
9
63
98
0.0001
5330
|
|
POL
LPEKDSWTV
435
9
40
63
0.0001
5331
|
|
POL
YPGIKVKQL
460
9
11
17
5332
|
|
POL
YPGIKVRQL
460
9
15
23
5333
|
|
POL
IPLTEEAEL
482
9
11
17
5334
|
|
POL
VPLTEEAEL
482
9
19
30
5335
|
|
POL
TPPLVKLWY
611
9
57
89
0.0001
5336
|
|
POL
EPIVGAEIP
624
9
21
33
0.0001
5337
|
|
POL
QPDKSESEL
701
9
37
58
0.0006
5338
|
|
POL
LPPIVAKEI
780
9
27
42
5339
|
|
POL
LPPVVAKEI
780
9
28
44
0.0006
5340
|
|
POL
PPIVAKEIV
781
9
26
41
5341
|
|
POL
PPVVAKEIV
781
9
28
44
0.0001
5342
|
|
POL
VPRRKAKII
1013
9
50
78
0.4800
5343
|
|
POL
VPRRKVKII
1013
9
11
17
5344
|
|
POL
SPTRKELQVW
29
10
13
20
0.0025
5345
|
|
POL
EPGEDRELSV
69
10
01
17
5346
|
|
POL
GPERALSVCL
70
10
01
20
5347
|
|
POL
LPGKWKPKMI
125
10
39
61
5348
|
|
POL
LPGRWKPKMI
125
10
15
23
0.0002
5349
|
|
POL
TPVNIIGRNL
167
10
26
41
0.0003
5350
|
|
POL
TPVNIIGRNM
167
10
24
30
5351
|
|
POL
SPIETVPVKL
189
10
53
83
0.0028
5352
|
|
POL
WPLTEEKIKA
211
10
54
84
0.0018
5353
|
|
POL
GPENPYNTPI
240
10
24
38
5354
|
|
POL
GPENPYNTPV
240
10
38
59
0.0002
5355
|
|
POL
NPYNTPIFAI
243
10
24
38
5356
|
|
POL
NPYNTPVFAI
243
10
37
58
0.0034
5357
|
|
POL
VPLDKDFRKY
307
10
18
28
0.0002
5358
|
|
POL
TPGIRYQYNV
328
10
51
80
0.0004
5359
|
|
POL
LPQGWKGSPA
338
10
58
92
0.0120
5360
|
|
POL
EPFRKQNPDI
358
10
16
25
0.0002
5361
|
|
POL
NPDIVIYQYM
364
10
17
27
0.0005
5362
|
|
POL
NPEIVIYQYM
364
10
23
36
5363
|
|
POL
PPFLWMGYEL
414
10
64
100
0.0002
5364
|
|
POL
IIPDKWTVQPI
424
10
53
83
0.0012
5365
|
|
POL
DPSKDLIAEI
512
10
26
41
0.0002
5366
|
|
POL
LPIQKETWEA
583
10
15
23
5367
|
|
POL
PPLVKLWYQL
612
10
53
83
0.0002
5368
|
|
POL
EPIVGAETFY
624
10
21
33
0.0002
5369
|
|
POL
QPDKSESEIV
701
10
37
58
0.0002
5370
|
|
POL
LPPIVAKEIV
780
10
26
41
5371
|
|
POL
LPPVVAKEIV
780
10
27
42
0.0002
5372
|
|
POL
PPIVAKEIVA
781
10
25
39
5373
|
|
POL
PPVVAKEIVA
781
10
28
44
0.0066
5374
|
|
POL
IPAETGQETA
841
10
58
91
0.0002
5375
|
|
POL
IPYNPQSQGV
893
10)
63
98
0.0023
5376
|
|
POL
DPIWKGPAKL
984
10
35
55
5377
|
|
POL
DPLWKGPAKL
984
10
15
23
0.0001
5378
|
|
POL
VPTFNFPQITL
79
11
01
17
5379
|
|
POL
FPQITLWQRPL
87
11
40
63
5380
|
|
POL
KPKMIGGIGGF
130
11
60
94
0.0004
5381
|
|
POL
TPVNIIGRNLL
167
11
26
41
0.0002
5382
|
|
POL
TPVNIIGRNML
167
11
24
38
5383
|
|
POL
FPISPIETVPV
186
11
55
86
0.0067
5384
|
|
POL
WPLTEEKIKAL
211
11
54
84
0.0001
5385
|
|
POL
GPENPYNTPIF
240
11
24
38
5386
|
|
POL
GPENPYNTPVF
240
11
38
59
0.0001
5387
|
|
POL
HPAGLKKKKS
285
11
50
78
0.0001
5388
|
|
POL
IPSINNETPGI
321
11
31
48
5389
|
|
POL
IPSTNNETPGI
321
11
11
17
5390
|
|
POL
TPGIRYQYNVL
328
11
51
80
0.0015
5391
|
|
POL
LPQGWKGSPAI
338
11
58
92
0.0002
5392
|
|
POL
EPFRKQNPDIV
358
11
14
22
5393
|
|
POL
EPPFLWMGYE
413
11
63
98
0.0001
5394
|
|
POL
IIPDKWTVQPI
424
11
12
19
5395
|
|
POL
QPIQLPEKDSW
431
11
13
20
5396
|
|
POL
QPIVLPEKDSW
431
11
13
20
5397
|
|
POL
IPLTEEAELEL
482
11
11
17
5398
|
|
POL
VPLTEEAELEL
482
11
19
30
5399
|
|
POL
EPFKNLKTGK
536
11
45
70
0.0001
5400
|
|
POL
LPIQKETWEA
583
11
15
23
5401
|
|
POL
LPIQKETWET
583
11
27
42
5402
|
|
POL
TPPLVKLWYQ
611
11
53
83
0.0001
5403
|
|
POL
EPIVGAETFYV
624
11
21
33
5404
|
|
POL
LPPIVAKEIVA
780
11
25
39
5405
|
|
POL
LPPVVAKEIVA
780
11
27
42
0.0001
5406
|
|
POL
IPAETGQETAY
841
11
58
91
0.0001
5407
|
|
POL
IPYNPQSQGVV
893
11
59
92
0.0120
5408
|
|
POL
NPQSQGVVES
896
11
53
83
0.0001
5409
|
|
POL
DPIWKGPAKLL
984
11
34
53
5410
|
|
POL
DPLWKGPAKL
984
11
14
22
5411
|
|
REV
SPEGTRQA
33
8
13
20
5412
|
|
REV
RPAEPVPL
70
8
20
31
5413
|
|
REV
VPLQLPPI
75
8
11
17
5414
|
|
REV
VPLQLPPL
75
8
36
56
0.0490
5415
|
|
REV
PPLERLTL
80
8
19
30
0.0001
5416
|
|
REV
LPPLERLTL
79
9
19
30
0.3100
5417
|
|
REV
QPQGTETGV
100
9
05
18
5418
|
|
REV
PPSPEGTRQA
30
10
12
19
5419
|
|
REV
RPAEPVPLQL
70
10
20
31
5420
|
|
REV
EPVPLQLPPI
73
10
11
17
5421
|
|
REV
EPVPLQLPPL
73
10
34
53
0.0023
5422
|
|
REV
TPPSPEGTRQA
29
11
12
19
5423
|
|
REV
VPLQLPPIERL
75
11
11
17
5424
|
|
REV
VPLQLPPLERL
75
11
34
53
0.0001
5425
|
|
TAT
IIPGSQPKTA
16
9
26
41
0.0007
5426
|
|
TAT
IIPGSQPRTA
16
9
10
16
5427
|
|
TAT
GPKESKKKV
90
9
13
20
5428
|
|
TAT
EPVDPNLEPW
2
10
14
22
5429
|
|
TAT
EPVDPRLEPW
2
10
13
20
0.0001
5430
|
|
VIF
IIPKISSEV
48
8
13
20
5431
|
|
VIF
IIPKVSSEV
48
8
19
30
5432
|
|
VIF
IIPRISSEV
48
8
13
20
5433
|
|
VIF
IPLGDARL
57
8
14
22
5434
|
|
VIF
IPLGEARL
57
8
20
31
5435
|
|
VIF
DPDLADQL
104
8
19
30
5436
|
|
VIF
DPGLADQL
104
8
19
30
5437
|
|
VIF
SPRCEYQA
135
8
21
33
0.0008
5438
|
|
VIF
IPLGDARLV
57
9
11
17
5439
|
|
VIF
IPLGIEARLV
57
9
19
30
5440
|
|
VIF
DPDLADQLI
104
9
19
30
0.0002
5441
|
|
VIF
DPGLADQLI
104
9
19
30
5442
|
|
VIF
KPKKIKPPL
160
9
10
16
5443
|
|
VIF
PPLPSVKKL
167
9
21
33
5444
|
|
VIF
PPLPSVRKL
167
9
14
22
5445
|
|
VIF
IIPKISSEVHI
48
10
13
20
5446
|
|
VIF
IIPKVSSEVHI
48
10
19
30
5447
|
|
VIF
IIPRISSEVHI
48
10
13
20
0.0330
5448
|
|
VIF
IPLGEARLVI
57
10
10
16
5449
|
|
VIF
KPPLPSVKKL
166
10
20
31
5450
|
|
VIF
DPDLADQLIIIL
104
11
18
28
5451
|
|
VPR
EPYNEWTL
13
8
30
47
5452
|
|
VPR
FPRIWLHSL
34
9
10
16
5453
|
|
VPR
PPRPWLIIGL
34
9
24
38
5454
|
|
VPR
GPQREPYNEW
9
10
37
58
0.0001
5455
|
|
VPR
EPYNEWTLEL
13
10
29
45
00054
5456
|
|
VPR
RPWLIIGLGQY
36
10
10
16
5457
|
|
VPR
EPYNEWTLEL
13
11
29
45
5458
|
|
VPR
RPWLHGLGQII
36
11
12
19
5459
|
|
VPU
APWDVDDL
99
8
12
19
5460
|
|
TABLE XII
|
|
|
HIV B27 Super Motif Peptides
|
No. of
Sequence
Conservancy
|
Protein
Sequence
Position
Amino Acids
Frequency
(%)
SEQ ID NO.
|
|
ENV
KKLWTLYL
9
8
01
50
5461
|
|
ENV
RKSWSLYI
9
8
01
50
5462
|
|
ENV
WRWGTLFL
15
8
01
50
5463
|
|
ENV
WRWGTMLL
15
8
01
50
5464
|
|
ENV
EKLWVTVY
43
8
09
15
5465
|
|
ENV
WKEATTTL
56
8
23
36
5466
|
|
ENV
MIIEDIISL
117
8
29
45
5467
|
|
ENV
IKNCSFNI
182
8
13
20
5468
|
|
ENV
PKVSFEPI
251
8
30
47
5469
|
|
ENV
LKCNDKKF
272
8
13
20
5470
|
|
ENV
AKTIIVQL
330
8
14
22
5471
|
|
ENV
QRGPGRAF
360
8
01
33
5472
|
|
ENV
KKKKTCIYI
374
8
01
50
5473
|
|
ENV
IRQAIICNI
381
8
17
27
5474
|
|
ENV
IKQIINMW
489
8
33
52
5475
|
|
ENV
IKQIVNMW
489
8
13
21
5476
|
|
ENV
QRVGQAMY
497
8
11
17
5477
|
|
ENV
FRPGGGDM
546
8
43
67
5478
|
|
ENV
WRSELYKY
557
8
54
84
5479
|
|
ENV
YKYKVVEI
562
8
13
20
5480
|
|
ENV
YKYKVVKI
562
8
29
45
5481
|
|
ENV
AIlQLLSGI
627
8
38
59
5482
|
|
ENV
VRQLLSGI
627
8
10
16
5483
|
|
ENV
LKLTVWGI
652
8
13
20
5484
|
|
ENV
EKNIQDLL
749
8
17
27
5485
|
|
ENV
EKNEQELL
749
8
18
28
5486
|
|
ENV
LRIIFAVL
790
8
17
27
5487
|
|
ENV
LRIVFAVL
790
8
28
44
5488
|
|
ENV
VRQGYSPL
803
8
56
88
5489
|
|
ENV
IRLVNGFL
843
8
11
17
5490
|
|
ENV
IRLVSGFL
843
8
13
20
5491
|
|
ENV
YHRLRDFI
865
8
13
20
5492
|
|
ENV
YIIRLRDLL
865
8
15
23
5493
|
|
ENV
IIRLRDFIL
866
8
13
20
5494
|
|
ENV
IIRLRDLLL
866
8
13
20
5495
|
|
ENV
GRRGWEAL
884
8
09
15
5496
|
|
ENV
LKGLRLGW
890
8
12
40
5497
|
|
ENV
LRGLQRGW
890
8
05
17
5498
|
|
ENV
LRLGWEGL
893
8
10
32
5499
|
|
ENV
LKYLWNLL
900
8
14
22
5500
|
|
ENV
LKYWWNLL
900
8
14
22
5501
|
|
ENV
LKNSAINL
914
8
10
16
5502
|
|
ENV
LKNSAISL
914
8
10
16
5503
|
|
ENV
LKNSAVSL
914
8
13
20
5504
|
|
ENV
PRRIRQGF
951
8
11
17
5505
|
|
ENV
PRRIRQGL
951
8
26
41
5506
|
|
ENV
GKDLWVTVY
42
9
01
33
5507
|
|
ENV
EKLWVTVYY
43
9
09
15
5508
|
|
ENV
WKEATTTLF
56
9
23
36
5509
|
|
ENV
WKNNMVEQM
109
9
35
55
5510
|
|
ENV
MIIEDIISLW
117
9
29
45
5511
|
|
ENV
GKNEINDTY
218
9
01
20
5512
|
|
ENV
IIIYCAPAGF
261
9
27
42
5513
|
|
ENV
IIIYCTPAGF
261
9
10
16
5514
|
|
ENV
IKPVVSTQL
298
9
33
52
5515
|
|
ENV
IRPVVSTQL
298
9
26
41
5516
|
|
ENV
CRIKQIINM
487
9
30
47
5517
|
|
ENV
CRIKQIVNM
487
9
12
19
5518
|
|
ENV
GKAMYAPPI
501
9
23
36
5519
|
|
ENV
GRAMYAPPI
501
9
12
19
5520
|
|
ENV
MRDNWRSEL
553
9
40
63
5521
|
|
ENV
YKVVKIEPL
564
9
25
39
5522
|
|
ENV
EREKRAVGI
590
9
11
17
5523
|
|
ENV
QIILLKLTVW
649
9
13
20
5524
|
|
ENV
QIILLQLTVW
649
9
34
53
5525
|
|
ENV
QIIMLQLTVW
649
9
10
16
5526
|
|
ENV
IKQLQARVL
659
9
40
63
5527
|
|
ENV
ARVLAVERY
664
9
33
52
5528
|
|
ENV
ERYLKDQQL
670
9
30
47
5529
|
|
ENV
ERYLRDQQL
670
9
18
28
5530
|
|
ENV
LKDQQLLGI
673
9
27
42
5531
|
|
ENV
LRDQQLLGI
673
9
19
30
5532
|
|
ENV
DKWASLWNW
759
9
26
41
5533
|
|
ENV
TKWLWYIKI
771
9
15
23
5534
|
|
ENV
LRNLCLFSY
857
9
16
25
5535
|
|
ENV
LRSLCLFSY
857
9
35
55
5536
|
|
ENV
YIIRLRDFIL
865
9
13
20
5537
|
|
ENV
YIIRLRDLLL
865
9
13
20
5538
|
|
ENV
IIRLRDLLLI
866
9
11
17
5539
|
|
ENV
LKNSAVSLL
914
9
11
17
5540
|
|
ENV
IRQGLERAL
954
9
34
53
5541
|
|
ENV
KKLWTLYLAM
9
10
01
50
5542
|
|
ENV
RKSWSLYIAM
9
10
01
50
5543
|
|
ENV
WRWGTLFLGM
15
10
01
50
5544
|
|
ENV
WRWGTMLLGM
15
10
01
50
5545
|
|
ENV
GKDLWVIVYY
42
10
01
33
5546
|
|
ENV
LKPCVKLTPL
129
10
55
86
5547
|
|
ENV
VKLTPLCVIL
133
10
52
81
5548
|
|
ENV
PKVSFEPIPI
251
10
30
47
5549
|
|
ENV
IKPVVSTQLL
298
10
33
52
5550
|
|
ENV
IRPVVSTQLL
298
10
26
41
5551
|
|
ENV
MIISFNCGGEF
433
10
13
20
5552
|
|
ENV
THSFNCGGEF
433
10
22
34
5553
|
|
ENV
THSFNCRGEF
433
10
13
20
5554
|
|
ENV
CRIKQIINMW
487
10
30
47
5555
|
|
ENV
CRIKQIVNMW
487
10
12
19
5556
|
|
ENV
IRCSSNITGL
513
10
12
19
5557
|
|
ENV
MRDNWRSELY
553
10
40
63
5558
|
|
ENV
KRAVGIGAVF
393
10
11
17
5559
|
|
ENV
LRAIEAQQIIL
642
10
45
70
5560
|
|
ENV
ARVLAVERYL
664
0
33
52
5561
|
|
ENV
ERYLKDQQLL
670
10
29
45
5562
|
|
ENV
ERYLRDQQLL
670
10
17
27
5563
|
|
ENV
LKDQQLLGIW
673
10
27
42
5564
|
|
ENV
LRDQQLLGIW
673
10
19
30
5565
|
|
ENV
EKNEQDLLAL
749
10
17
27
5566
|
|
ENV
EKNEQELLEL
749
10
13
20
5567
|
|
ENV
DKWASLWNWF
759
10
26
41
5568
|
|
ENV
TKWLWYIKIF
771
10
12
19
5569
|
|
ENV
LRIIFAVLSI
790
10
14
22
5570
|
|
ENV
LRIVFAVLSI
790
10
19
30
5571
|
|
ENV
NRVRQGYSPL
801
10
52
81
5572
|
|
ENV
VRQGYSPLSF
803
10
48
75
5573
|
|
ENV
PRGPDRPEGI
820
10
12
19
5574
|
|
ENV
IRLVSGFLAL
843
10
11
17
5575
|
|
ENV
YIIRLRDLLLI
865
10
11
17
5576
|
|
ENV
LRLGWEGLKY
893
10
09
29
5577
|
|
ENV
LKYWWNLLQY
900
10
14
22
5578
|
|
ENV
IRQGLERALL
954
10
33
52
5579
|
|
ENV
WRWGTLFLGML
15
11
01
50
5580
|
|
ENV
WRWGTMLLGML
15
11
01
50
5581
|
|
ENV
YRLINCNTSAI
235
11
15
24
5582
|
|
ENV
IIIYCAPAGFAI
261
11
27
42
5583
|
|
ENV
IKPVVSTQLLL
298
11
33
52
5584
|
|
ENV
IRPVVSTQLLL
298
11
26
41
5585
|
|
ENV
TRPNNNTRKSI
346
11
12
19
5586
|
|
ENV
QRGPGRAFVTI
360
11
01
33
5587
|
|
ENV
MHSFNCGGEFF
433
11
13
20
5588
|
|
ENV
THSFNCGGEFF
433
11
21
33
5589
|
|
ENV
THSFNCRGEFF
433
11
13
20
5590
|
|
ENV
IRCSSNITGLL
513
11
10
16
5591
|
|
ENV
YKYKVVKIEPL
562
11
25
39
5592
|
|
ENV
EKRAVGIGAVF
592
11
10
16
5593
|
|
ENV
KRAVGIGAVFL
593
11
11
17
5594
|
|
ENV
LRAIEAQQHLL
642
11
44
69
5595
|
|
ENV
QHLLKLTVWGI
649
11
13
20
5596
|
|
ENV
QHLLQLTVWGI
649
11
34
53
5597
|
|
ENV
LKLTVWGIKQL
652
11
13
20
5598
|
|
ENV
GKLICTTAVPW
686
11
19
30
5599
|
|
ENV
GKLICTTNVPW
686
11
17
27
5600
|
|
ENV
GKLICTTTVPW
686
11
12
19
5601
|
|
ENV
TKWLWYIKIFI
771
11
12
19
5602
|
|
ENV
IKIFIMIVGGL
777
11
38
59
5603
|
|
ENV
LKGLRLGWEGL
890
11
08
27
5604
|
|
ENV
LRLGWEGLKYL
893
11
09
29
5605
|
|
ENV
LKYWWNLLQYW
900
11
14
22
5606
|
|
ENV
LHIPRRIRQGL
948
11
12
19
5607
|
|
ENV
RRIRQGLERAL
952
11
16
25
5608
|
|
ENV
TRIRQGLERAL
952
11
11
17
5609
|
|
GAG
DKWEKIRL
14
8
18
28
5610
|
|
GAG
KKYKLKIII
28
8
10
16
5611
|
|
GAG
KKYRLKIIL
28
8
16
25
5612
|
|
GAG
YKLKIIIVW
30
8
13
20
5613
|
|
GAG
YRLKIILVW
30
8
17
27
5614
|
|
GAG
CRQILGQL
59
8
15
23
5615
|
|
GAG
IKDTKEAL
96
8
10
16
5616
|
|
GAG
VKDTKEAL
96
8
33
52
5617
|
|
GAG
VRDTKEAL
96
8
10
16
5618
|
|
GAG
TKEALDKI
99
8
33
52
5619
|
|
GAG
TKEALEKI
99
8
10
16
5620
|
|
GAG
GIIQAAMQM
214
8
61
95
5621
|
|
GAG
KRWIILGL
287
8
55
86
5622
|
|
GAG
PKEPFRDY
313
8
63
98
5623
|
|
GAG
FRDYVDRF
317
8
64
100
5624
|
|
GAG
CKTILKAL
354
8
28
44
5625
|
|
GAG
CKTILIIAL
354
8
18
28
5626
|
|
GAG
ARVLAEAM
384
8
57
89
5627
|
|
GAG
IIKGRPGNF
477
8
23
37
5628
|
|
GAG
NKGRPGNF
477
8
14
23
5629
|
|
GAG
SKGRPGNF
477
8
11
18
5630
|
|
GAG
LKDKEPPL
535
8
01
25
5631
|
|
GAG
ERTENSLY
537
8
01
25
5632
|
|
GAG
EKEEKGLY
538
8
01
25
5633
|
|
GAG
GKLDAWEKI
11
9
17
27
5634
|
|
GAG
LRPGGKKKY
21
9
35
55
5635
|
|
GAG
KKKYRLKHL
27
9
13
20
5636
|
|
GAG
SRELERFAL
39
9
22
34
5637
|
|
GAG
ERFALNPGL
44
9
15
23
5638
|
|
GAG
ERFAVNPGL
44
9
15
23
5639
|
|
GAG
VKVIEEKAF
177
9
24
38
5640
|
|
GAG
VKVVEEKAF
177
9
28
44
5641
|
|
GAG
EKAFSPEVI
182
9
48
75
5642
|
|
GAG
GIIQAAMQML
214
9
61
95
5643
|
|
GAG
LIIPVHAGPI
236
9
22
34
5644
|
|
GAG
VIIPVIIAGPI
236
9
14
22
5645
|
|
GAG
MREPRGSDI
249
9
44
69
5646
|
|
GAG
YKRWIILGL
286
9
55
86
5647
|
|
GAG
VRMYSPTSI
298
9
14
22
5648
|
|
GAG
VRMYSPVSI
298
9
40
63
5649
|
|
GAG
IKQGPKEPF
309
9
20
31
5650
|
|
GAG
IRQGPKEPF
309
9
42
66
5651
|
|
GAG
FRDYVDRFF
317
9
35
55
5652
|
|
GAG
FRDYVDRFY
317
9
29
45
5653
|
|
GAG
VKNWMTDTL
337
9
16
25
5654
|
|
GAG
VKNWMTETL
337
9
36
56
5655
|
|
GAG
SHKGRPGNF
476
9
23
37
5656
|
|
GAG
HKGRPGNFL
477
9
23
37
5657
|
|
GAG
NKGRPGNFL
477
9
09
15
5658
|
|
GAG
RKEPTAPPL
492
9
01
50
5659
|
|
GAG
DKDKELYPL
536
9
01
25
5660
|
|
GAG
GKKKYRLKIIL
25
10
12
19
5661
|
|
GAG
KKYKLKIIIVW
28
10
10
16
5662
|
|
GAG
KKYRLKIILVW
28
10
16
25
5663
|
|
GAG
KIIIYWASREL
33
10
21
33
5664
|
|
GAG
KIILVWASREL
33
10
36
56
5665
|
|
GAG
ERFALNPGLL
44
10
15
23
5666
|
|
GAG
ERFAVNPGLL
44
10
15
23
5667
|
|
GAG
VIIQAISPRTL
164
10
27
42
5668
|
|
GAG
VIIQALSPRTL
164
10
11
17
5669
|
|
GAG
VRMYSPTSIL
298
10
14
22
5670
|
|
GAG
VRMYSPVSIL
298
10
40
63
5671
|
|
GAG
VKNWMTDTLL
337
10
16
25
5672
|
|
GAG
VKNWMTETLL
337
10
36
56
5673
|
|
GAG
LKALGPAAIL
358
10
16
25
5674
|
|
GAG
IIKARVLAEAM
382
10
57
89
5675
|
|
GAG
CRAPRKKGCW
438
10
53
83
5676
|
|
GAG
WKCGKEGIIQM
447
10
46
72
5677
|
|
GAG
ERQANFLGKI
464
10
54
84
5678
|
|
GAG
SIIKGRPGNFL
476
10
23
37
5679
|
|
GAG
TRKEPTAPPL
491
10
01
50
5680
|
|
GAG
QKQEPIDKEL
530
10
12
19
5681
|
|
GAG
EKEEKGLYPL
538
10
01
25
5682
|
|
GAG
DKELYPLASL
541
10
13
21
5683
|
|
GAG
DKELYPLTSL
541
10
10
16
5684
|
|
GAG
LKSLFGNDPL
552
10
12
19
5685
|
|
GAG
ARASVLSGGEL
3
11
11
17
5686
|
|
GAG
ARASVLSGGKL
3
11
28
44
5687
|
|
GAG
GKLDAWEKIRL
11
11
16
25
5688
|
|
GAG
IRLRPGGKKKY
19
11
33
52
5689
|
|
GAG
LRPGGKKKYKL
21
11
10
16
5690
|
|
GAG
LRPGGKKKYRL
21
11
16
25
5691
|
|
GAG
KKKYRLKHLVW
27
11
13
20
5692
|
|
GAG
LKHIVWASREL
32
11
21
33
5693
|
|
GAG
LKHLVWASREL
32
11
22
34
5694
|
|
GAG
LRSLYNTVATL
77
11
13
20
5695
|
|
GAG
VKDTKEALDKI
96
11
16
25
5696
|
|
GAG
PRTLNAWVKVI
170
11
30
48
5697
|
|
GAG
EKAFSPEVIFM
182
11
48
75
5698
|
|
GAG
DRLHPVIIAGPI
234
11
22
34
5699
|
|
GAG
DRVHPVIIAGPl
234
11
14
22
5700
|
|
GAG
VIIAGPIAPGQM
239
11
17
27
5701
|
|
GAG
VIIAGPIPPGQM
239
11
17
27
5702
|
|
GAG
KRWIILGLNKI
287
11
55
86
5703
|
|
GAG
GIIKARVLAEAM
381
11
35
55
5704
|
|
GAG
SHKARVLAEAM
381
11
19
30
5705
|
|
GAG
MKDCTERQANF
456
11
50
78
5706
|
|
GAG
ERQANFLGKIW
464
11
54
84
5707
|
|
GAG
QKQEPIDKELY
530
11
12
19
5708
|
|
GAG
LKDKEPPLASL
535
11
01
25
5709
|
|
GAG
ERTENSLYPPL
537
11
01
25
5710
|
|
NEF
GKWSKSSI
3
8
18
28
5711
|
|
NEF
SKSSIVGW
6
8
20
31
5712
|
|
NEF
EKGGLDGL
121
8
26
41
5713
|
|
NEF
EKGGLEGL
121
8
34
53
5714
|
|
NEF
SKKRQEIL
177
8
25
39
5715
|
|
NEF
KRQDILDL
181
8
18
28
5716
|
|
NEF
KRQEILDL
181
8
32
50
5717
|
|
NEF
ARELIIPEF
322
8
11
17
5718
|
|
NEF
ARELIIPEY
322
8
24
38
5719
|
|
NEF
EKGGLDGLI
121
9
23
36
5720
|
|
NEF
EKGGLEGLI
121
9
27
42
5721
|
|
NEF
KKRQEILDL
179
9
25
39
5722
|
|
NEF
QKRQDILDL
179
9
12
19
5723
|
|
NEF
KRQDILDLW
181
9
18
28
5724
|
|
NEF
KRQEILDLW
181
9
32
50
5725
|
|
NEF
IRYPLTFIW
214
9
13
20
5726
|
|
NEF
TRFPLTFGW
214
9
12
19
5727
|
|
NEF
LIIPICQIIGM
258
9
10
16
5728
|
|
NEF
LIIPMSQIIGM
258
9
12
19
5729
|
|
NEF
ARELIIPEFY
322
9
11
17
5730
|
|
NEF
ARELIIPEYY
322
9
21
33
5731
|
|
NEF
SRDLEKIAGAI
50
10
14
22
5732
|
|
NEF
VRPQVPLRPM
97
10
47
73
5733
|
|
NEF
LRPMTYKGAF
103
10
12
19
5734
|
|
NEF
SIIFLKEKGGL
115
10
29
45
5735
|
|
NEF
LKEKGGLDGL
118
10
26
42
5736
|
|
NEF
LKEKGGLEGL
118
10
29
47
5737
|
|
NEF
EKGGLDGLIY
121
10
21
33
5738
|
|
NEF
EKGGLEGLIV
121
10
19
30
5739
|
|
NEF
SKKRQEILDL
177
10
25
39
5740
|
|
NEF
KKRQEILDLW
179
10
25
39
5741
|
|
NEF
QKRQDILDLW
179
10
12
19
5742
|
|
NEF
YIITQGFFPDW
193
10
14
22
5743
|
|
NEF
YIITQGYFPDW
193
10
25
39
5744
|
|
NEF
GKWSKSSIVGW
3
11
18
28
5745
|
|
NEF
LKEKGGLDGLI
118
11
23
37
5746
|
|
NEF
LKEKGGLEGLI
118
11
24
39
5747
|
|
NEF
SKKRQEILDLW
177
11
25
39
5748
|
|
NEF
KRQDILDLWVY
181
11
16
25
5749
|
|
NEF
KRQEILDLWVY
181
11
29
45
5750
|
|
NEF
TRFPLTFGWCF
214
11
10
16
5751
|
|
POL
TRRELQVW
43
8
13
20
5752
|
|
POL
GKWKPKMI
127
8
41
64
5753
|
|
POL
GRWKPKMI
127
8
16
25
5754
|
|
POL
VRQYDQIL
143
8
21
33
5755
|
|
POL
HKAIGTVL
156
8
20
31
5756
|
|
POL
KKAIGTVL
156
8
29
45
5757
|
|
POL
GRNLLTQI
173
8
21
33
5758
|
|
POL
GRNMLTQI
173
8
19
30
5759
|
|
POL
GRNMLTQL
173
8
11
17
5760
|
|
POL
PKVKQWPL
206
8
51
80
5761
|
|
POL
KKKDSTKW
253
8
57
89
5762
|
|
POL
NKRTQDFW
270
8
57
89
5763
|
|
POL
KKKSVTVL
291
8
50
78
5764
|
|
POL
RKYTAFTI
314
8
62
97
5765
|
|
POL
IRYQYNVL
331
8
53
83
5766
|
|
POL
WKGSPAIF
342
8
59
92
5767
|
|
POL
FRKQNPDI
360
8
16
25
5768
|
|
POL
IIRAKIEEL
387
8
26
41
5769
|
|
POL
IIRTKIEEL
387
8
22
34
5770
|
|
POL
LREIILLKW
394
8
17
27
5771
|
|
POL
LRQIILLRW
394
8
15
23
5772
|
|
POL
EIILLKWGF
396
8
4
22
5773
|
|
POL
QIILLRWGF
396
8
12
19
5774
|
|
POL
KIIQKEPPF
409
8
62
97
5775
|
|
POL
QKEPPFLW
411
8
63
98
5776
|
|
POL
DKWTVQPI
426
8
54
84
5777
|
|
POL
VKQLCKLL
465
8
28
44
5778
|
|
POL
VRQLCKLL
465
8
19
30
5779
|
|
POL
TKALITEVI
475
8
11
17
5780
|
|
POL
SKDLIAEI
514
8
27
42
5781
|
|
POL
QKQGQDQW
522
8
16
25
5782
|
|
POL
QKQGQGQW
522
8
24
38
5783
|
|
POL
QKIATESI
565
8
14
22
5784
|
|
POL
GKTPKFKL
576
8
17
27
5785
|
|
POL
GKTPKFRL
576
8
30
47
5786
|
|
POL
QKETWEAW
586
8
15
23
5787
|
|
POL
QKETWETW
586
8
27
42
5788
|
|
POL
TKIGKAGY
642
8
10
16
5789
|
|
POL
TKLGKAGY
642
8
36
56
5790
|
|
POL
GRQKVVSL
654
8
24
38
5791
|
|
POL
QKTELHAI
667
8
12
19
5792
|
|
POL
QKTELQAI
667
8
42
66
5793
|
|
POL
IKKEKVYL
718
8
35
55
5794
|
|
POL
DKLVSAGI
741
8
16
25
5795
|
|
POL
DKLVSSGI
741
8
29
45
5796
|
|
POL
YHNNWRAM
767
8
10
16
5797
|
|
POL
YHSNWRAM
767
8
39
61
5798
|
|
POL
WRAMASDF
771
8
43
67
5799
|
|
POL
THLEGKII
818
8
35
55
5800
|
|
POL
THLEGKVI
818
8
26
41
5801
|
|
POL
VIIVASGYI
829
8
53
83
5802
|
|
POL
GRWPVKTI
858
8
13
21
5803
|
|
POL
GRWPVKVI
858
8
22
35
5804
|
|
POL
NKELKKII
907
8
57
89
5805
|
|
POL
VRDQAEIIL
917
8
48
75
5806
|
|
POL
VREQAEIIL
917
8
13
20
5807
|
|
POL
RKGGIGGY
939
8
59
92
5808
|
|
POL
TKELQKQI
962
8
47
75
5809
|
|
POL
YRDSRDPI
979
8
35
55
5810
|
|
POL
YRDSRDPL
979
8
14
22
5811
|
|
POL
WKGPAKLL
987
8
59
92
5812
|
|
POL
PRRKAKII
1014
8
50
78
5813
|
|
POL
PRRKVKII
1014
8
11
17
5814
|
|
POL
IKDYGKQM
1021
8
11
17
5815
|
|
POL
IRDYGKQM
1021
8
50
78
5816
|
|
POL
QRPLVTIKI
94
9
14
22
5817
|
|
POL
QRPLVTVKI
94
9
12
19
5818
|
|
POL
WKPKMIGGI
129
9
60
94
5819
|
|
POL
IKVRQYDQI
141
9
41
64
5820
|
|
POL
VRQYDQILI
143
9
20
31
5821
|
|
POL
VRQYDQIPI
143
9
13
20
5822
|
|
POL
GIIKAIGTVL
155
9
20
31
5823
|
|
POL
GKKAIGTVL
155
9
29
45
5824
|
|
POL
EKIKALTEI
216
9
28
44
5825
|
|
POL
EKIKALVEI
216
9
15
23
5826
|
|
POL
EKEGKISKI
231
9
36
56
5827
|
|
POL
SKIGPENPY
237
9
42
66
5828
|
|
POL
SRIGPENPY
237
9
11
17
5829
|
|
POL
IKKKDSTKW
252
9
57
89
5830
|
|
POL
TKWRKLVDF
258
9
59
92
5831
|
|
POL
RKLVDFREL
261
9
63
98
5832
|
|
POL
KKKKSVTVL
290
9
50
78
5833
|
|
POL
FRKYTAFTI
313
9
61
97
5834
|
|
POL
RKQNPDIVI
361
9
14
22
5835
|
|
POL
QIIRAKIEEL
386
9
26
41
5836
|
|
POL
QIIRTKIEEL
386
9
22
34
5837
|
|
POL
KKIIQKEPPF
408
9
60
94
5838
|
|
POL
KIIQKEPPFL
409
9
62
97
5839
|
|
POL
QKEPPFLWM
411
9
63
98
5840
|
|
POL
QKLVGKLNW
447
9
62
97
5841
|
|
POL
GKINWASQI
451
9
61
95
5842
|
|
POL
IKVKQICKL
463
9
29
45
5843
|
|
POL
IKVRQLCKI
463
9
18
28
5844
|
|
POL
LKEPVIIGVY
502
9
41
64
5845
|
|
POL
FKNLKTGKY
538
9
45
70
5846
|
|
POL
YKNLKTGKY
538
9
10
16
5847
|
|
POL
LKTGKYAKM
541
9
19
30
5848
|
|
POL
LKTGKYARM
541
9
13
20
5849
|
|
POL
AHTNDVKQL
552
9
46
72
5850
|
|
POL
QKETWEAWW
586
9
15
23
5851
|
|
POL
QKETWETWW
586
9
27
42
5852
|
|
POL
QKTEIQAIY
667
9
12
19
5853
|
|
POL
KKEKVYIAW
719
9
20
32
5854
|
|
POL
KKEKVYISW
719
9
13
21
5855
|
|
POL
RKVIFIDGI
749
9
50
78
5856
|
|
POL
DHEKYHSNW
763
9
10
16
5857
|
|
POL
EHEKYHSNW
763
9
20
31
5858
|
|
POL
EHERYHSNW
763
9
13
20
5859
|
|
POL
THLEGKIIL
818
9
31
48
5860
|
|
POL
THLEGKVIL
818
9
23
36
5861
|
|
POL
IHTDNGSNF
865
9
42
66
5862
|
|
POL
IKQEFGSPY
887
9
26
45
5863
|
|
POL
EHLKTAVQM
922
9
57
89
5864
|
|
POL
KRKGGIGGY
938
9
59
92
5865
|
|
POL
TKELQKQSI
962
9
50
56
5866
|
|
POL
SKSQNFRVY
970
9
52
59
5867
|
|
POL
TKIQNFRVY
970
9
37
58
5868
|
|
POL
YRDSRDPIW
979
9
35
55
5869
|
|
POL
YRDSRDPLW
979
9
54
22
5870
|
|
POL
WKGPAKLLW
987
9
59
92
5875
|
|
POL
WKGEGAVVS
995
9
65
95
5872
|
|
POL
RKAKIIRDY
1016
9
45
64
5873
|
|
POL
PKMSGGSGGF
131
10
62
97
5874
|
|
POL
SKYRQYDQIL
141
10
25
33
5875
|
|
POL
KKDSTKWRKL
254
10
58
95
5876
|
|
POL
WRKLVDFREL
260
10
63
98
5877
|
|
POL
LKKKKSVIVL
289
10
49
78
5878
|
|
POL
DKDFRKYTAF
350
10
58
28
5879
|
|
POL
FRKQNPDIVI
360
10
14
22
5880
|
|
POL
RKQNPDSVSY
365
10
54
22
5885
|
|
POL
AKIEELREIIL
389
10
53
20
5882
|
|
POL
TKIEELRQIIL
389
10
54
22
5883
|
|
POL
LREIILLKWGF
394
10
54
22
5884
|
|
POL
LRQSSLLRWGF
394
10
52
59
5885
|
|
POL
DKKISQKEPPF
407
10
60
94
5886
|
|
POL
KKHQKEPPFL
408
10
60
94
5887
|
|
POL
KHQKEPPFLW
409
10
62
97
5888
|
|
POL
DKWTVQPSQL
426
10
28
44
5889
|
|
POL
DKWSVQPSVL
426
10
52
59
5890
|
|
POL
EKDSWTVNDS
437
10
45
64
5895
|
|
POL
GKLNWASQSY
455
10
60
94
5892
|
|
POL
SKVKQLCKLL
463
10
28
44
5893
|
|
POL
SKVRQLCKLL
463
10
58
28
5894
|
|
POL
CKLLRGAKAL
469
10
25
39
5895
|
|
POL
CKLLRGTKAL
469
10
24
38
5896
|
|
POL
LRGAKALTDI
472
10
22
34
5897
|
|
POL
AKALTDIVPL
475
10
57
27
5898
|
|
POL
TKALTEVSPL
475
10
55
57
5899
|
|
POL
LKEPVHGVYY
502
10
39
65
5900
|
|
POL
QKQGQDQWTY
522
10
55
23
5901
|
|
POL
QKQGQGQWTY
522
10
24
38
5902
|
|
POL
QKIATESIVI
565
10
54
22
5903
|
|
POL
GKTPKFKLPI
576
10
57
27
5904
|
|
POL
GKTPKFRLPI
576
10
29
45
5905
|
|
POL
FKLPIQKETW
585
10
20
32
5906
|
|
POL
FRLPIQKETW
585
10
26
45
5907
|
|
POL
DRGRQKVVSL
652
10
58
28
5908
|
|
POL
QKTELQAIHL
667
10
55
23
5909
|
|
POL
QKTELQAIYL
667
10
52
59
5905
|
|
POL
IHLALQDSGL
674
10
15
23
5911
|
|
POL
IKKEKVYLAW
718
10
20
31
5912
|
|
POL
IKKEKVYLSW
718
10
13
20
5913
|
|
POL
IRKVLFLDGI
748
10
49
77
5914
|
|
POL
DKAQEEHEKY
758
10
25
39
5915
|
|
POL
DKAQEEIERY
758
10
15
23
5916
|
|
POL
EKYIISNWRAM
765
10
28
44
5917
|
|
POL
ERYIISNWRAM
765
10
10
16
5918
|
|
POL
WRAMASDFNL
771
10
41
64
5919
|
|
POL
DKCQLKGEAM
793
10
44
69
5920
|
|
POL
VKAACWWAGI
878
10
31
48
5921
|
|
POL
LKTAVQMAVF
924
10
57
89
5922
|
|
POL
IIINFKRKGGI
934
10
58
91
5923
|
|
POL
FKRKGGIGGY
937
10
59
92
5924
|
|
POL
QKQIIKIQNF
966
10
12
19
5925
|
|
POL
QKQITKIQNF
966
10
34
53
5926
|
|
POL
IKIQNFRVYY
970
10
12
19
5927
|
|
POL
TKIQNFRVYY
970
10
37
58
5928
|
|
POL
RRKAKIIRDY
1015
10
41
64
5929
|
|
POL
TRANSPTRREL
22
11
11
17
5930
|
|
POL
ERAIISPATREL
25
11
01
50
5931
|
|
POL
SRANSVTSRDL
25
11
01
50
5932
|
|
POL
TRANSVSSREL
34
11
01
33
5933
|
|
POL
TRANSVTTREL
36
11
01
33
5934
|
|
POL
IKIGGQLKEAL
100
11
19
30
5935
|
|
POL
GKWKVKMIGGI
127
11
41
64
5936
|
|
POL
GRWKVKMIGGI
127
11
16
25
5937
|
|
POL
VKMIGGIGGFI
131
11
62
97
5938
|
|
POL
IKVRQYDQILI
141
11
20
31
5939
|
|
POL
IKVRQYDQIVI
141
11
13
20
5940
|
|
POL
VRQYDQILIEI
143
11
20
31
5941
|
|
POL
VRQYDQIVIEI
143
11
12
19
5942
|
|
POL
VKQWVLTEEKI
208
11
52
81
5943
|
|
POL
IKALVEICTEM
218
11
15
23
5944
|
|
POL
KKKDSTKWRKL
253
11
57
89
5945
|
|
POL
FRELNKRTQDF
266
11
57
89
5946
|
|
POL
KRTQDFWEVQL
271
11
52
81
5947
|
|
POL
RKYTAFTIPSI
314
11
37
58
5948
|
|
POL
FRKQNVDIVIY
360
11
14
22
5949
|
|
POL
AKIEELREHLL
389
11
13
20
5950
|
|
POL
TKIEELRQIILL
389
11
14
22
5951
|
|
POL
DKKIIQKEVVFL
407
11
60
94
5952
|
|
POL
KKIIQKEVVFLW
408
11
60
94
5953
|
|
POL
KIIQKEVVFLWM
409
11
62
97
5954
|
|
POL
QKEVVFLWMGY
411
11
63
98
5955
|
|
POL
LHVDKWTVQPI
423
11
53
83
5956
|
|
POL
LRGTKALTEVI
472
11
11
17
5957
|
|
POL
VKQLTEAVQKI
557
11
30
47
5958
|
|
POL
QKIATESIVIW
565
11
14
22
5959
|
|
POL
EKEVIVGAETF
622
11
16
25
5960
|
|
POL
NRETKLGKAGY
639
11
28
44
5961
|
|
POL
DKSESELVNQI
703
11
18
28
5962
|
|
POL
DKSESELVSQI
703
11
19
30
5963
|
|
POL
MHGQVDCSPGI
802
11
52
81
5964
|
|
POL
LKTAVQMAVFI
924
11
56
88
5965
|
|
POL
ERIIDIIASDI
950
11
12
19
5966
|
|
POL
ERIIDIIATDI
950
11
29
45
5967
|
|
POL
ERIVDIIATDI
950
11
11
17
5968
|
|
POL
TKELQKQIIKI
962
11
10
16
5969
|
|
POL
TKELQKQITKI
962
11
31
49
5970
|
|
POL
IKVVPRRKAKI
1010
11
51
80
5971
|
|
POL
IKVVPRRKVKI
1010
11
11
17
5972
|
|
POL
PRRKAKIIRDY
1014
11
41
64
5973
|
|
POL
AKIIRDYGKQM
1018
11
42
66
5974
|
|
REV
VRIIKILY
18
8
18
28
5975
|
|
REV
RKNRRRRW
42
8
21
33
5976
|
|
REV
RRNRRRRW
42
8
40
63
5977
|
|
REV
WRARQRQI
49
8
36
56
5978
|
|
REV
WRERQRQI
49
8
11
17
5979
|
|
REV
ERILSTCL
61
8
11
17
5980
|
|
REV
ARKNRRRRW
41
9
18
28
5981
|
|
REV
ARRNRRRRW
41
9
39
61
5982
|
|
REV
ARQRQIIISI
51
9
10
16
5983
|
|
REV
GRPAEPVPL
69
9
20
31
5984
|
|
REV
GRSAEPVPL
69
9
12
19
5985
|
|
REV
GRSGDSDEEL
3
10
17
27
5986
|
|
REV
IKILYQSNPY
21
10
25
39
5987
|
|
REV
RRWRARQRQI
47
10
34
53
5988
|
|
REV
RRWRERQRQI
47
10
11
17
5989
|
|
REV
GRSGDSDEELL
3
11
16
25
5990
|
|
REV
RRRWRARQRQI
46
11
34
53
5991
|
|
REV
RRRWRERQRQI
46
11
11
17
5992
|
|
REV
WRARQRQIIISI
49
11
10
16
5993
|
|
REV
GRPAEPVPLQL
69
11
20
31
5994
|
|
REV
GRSAEPVPLQL
69
11
12
19
5995
|
|
TAT
KKGLGISY
43
8
15
23
5996
|
|
TAT
NKGLGISY
43
8
14
22
5997
|
|
TAT
TKGLGISY
43
8
19
30
5998
|
|
VIF
DRMKIRTW
14
8
12
19
5999
|
|
VIF
DRMRINTW
14
8
10
16
6000
|
|
VIF
DRMRIRTW
14
8
32
50
6001
|
|
VIF
ARLVITTY
64
8
11
17
6002
|
|
VIF
LHTGERDW
74
8
22
34
6003
|
|
VIF
GHGVSIEW
85
8
31
48
6004
|
|
VIF
GHNKVGSL
143
8
47
73
6005
|
|
VIF
NKVGSLQY
145
8
47
73
6006
|
|
VIF
PKKIKPPL
161
8
19
30
6007
|
|
VIF
KKLTEDRW
176
8
13
21
6008
|
|
VIF
GHRGSIITM
191
8
25
39
6009
|
|
VIF
NRWQVLIVW
3
9
10
16
6010
|
|
VIF
NRWQVMIVW
3
9
42
66
6011
|
|
VIF
MKIRTWNSL
16
9
12
19
6012
|
|
VIF
MKIRTWKSL
16
9
15
23
6013
|
|
VIF
MRIRTWNSL
16
9
15
23
6014
|
|
VIF
WKSLVKHHM
21
9
18
28
6015
|
|
VIF
WKSLVKYHM
21
9
10
16
6016
|
|
VIF
PKISSLVIII
49
9
15
23
6017
|
|
VIF
PKVSSEVIII
49
9
20
31
6018
|
|
VIF
PRISSEVIII
49
9
15
23
6019
|
|
VIF
ARLVITTYW
64
9
11
17
6020
|
|
VIF
WIILGIIGVSI
82
9
23
36
6021
|
|
VIF
WIILGQGVSI
82
9
26
41
6022
|
|
VIF
IIILYYFDCP
112
9
16
25
6023
|
|
VIF
IIIMIIYFDCP
112
9
15
23
6024
|
|
VIF
NKVGSLQYL
145
9
47
75
6025
|
|
VIF
VKKLTEDRW
175
9
13
20
6026
|
|
VIF
WKSLVKIIIIMY
21
10
18
28
6027
|
|
VIF
AKGWFYRIIIIY
35
10
10
16
6028
|
|
VIF
VIIIPLGDARL
55
10
13
20
6029
|
|
VIF
VIIIPLGEARL
55
10
20
31
6030
|
|
VIF
LIITGERDWIIL
74
10
21
33
6031
|
|
VIF
GIIGVSIEWRL
85
10
15
23
6032
|
|
VIF
GIINKVGSLQY
143
10
47
73
6033
|
|
VIF
IKPKKIKPPL
159
10
10
16
6034
|
|
VIF
TKGIIRGSHTM
189
10
18
29
6035
|
|
VIF
DRMKIRTWNSL
14
11
12
19
6036
|
|
VIF
DRMRIRTWKSL
14
11
15
23
6037
|
|
VIF
DRMRIRTWNSL
14
11
15
23
6038
|
|
VIF
WKSLVKHIIMYI
21
11
11
17
6039
|
|
VIF
RIIPKVSSEVHI
47
11
16
25
6040
|
|
VIF
PKISSEVIIIPL
49
11
14
22
6041
|
|
VIF
PKVSSEVIIIPL
49
11
19
30
6042
|
|
VIF
PRISSEVIIIPL
49
11
13
20
6043
|
|
VIF
ARLVITTYWGL
64
11
11
17
6044
|
|
VIF
WIILGIIGVSIEW
82
11
23
36
6045
|
|
VIF
WIILGQGVSIEW
82
11
26
41
6046
|
|
VIF
GIINKVGSLQYL
143
11
47
73
6047
|
|
VIF
NKVGSLQYLAL
145
11
46
73
6048
|
|
VPR
QREPYNEW
11
8
38
59
6049
|
|
VPR
VRHPPRIW
31
8
14
22
6050
|
|
VPR
VRHPPRPW
31
8
34
53
6051
|
|
VPR
RHPPRIWL
32
8
14
22
6052
|
|
VPR
RHPPRPWL
32
8
34
53
6053
|
|
VPR
PRIWLHSL
35
8
10
16
6054
|
|
VPR
PRPWLHGL
35
8
24
38
6055
|
|
VPR
LHGLGQHI
39
8
20
31
6056
|
|
VPR
IRILQQLL
61
8
45
70
6057
|
|
VPR
CRHSRIGI
77
8
11
17
6058
|
|
VPR
QHSRIGII
78
8
16
25
6059
|
|
VPR
LKNEAVRHF
26
9
18
28
6060
|
|
VPR
LKQEAVRHF
26
9
11
57
6065
|
|
VPR
LKSEAVRHF
26
9
15
23
6062
|
|
VPR
VRIIFPKIWL
35
9
14
22
6063
|
|
VPR
VRIIFPRPWL
35
9
34
53
6064
|
|
VPR
LIIGLGQIIIY
39
9
20
31
6065
|
|
VPR
IRILQQLLF
65
9
44
69
6066
|
|
VPR
QREPYNEWTL
11
10
30
47
6067
|
|
VPR
IRILQQLLFI
61
10
36
56
6068
|
|
VPR
FRIGCQIISRI
73
10
44
69
6069
|
|
VPR
FRIGCRIISRI
73
10
12
19
6070
|
|
VPR
RIIFPRIWLIISL
32
11
10
16
6071
|
|
VPR
RIIFPRPWLIIGL
32
11
24
38
6072
|
|
VPR
PRPWLHGLGQY
35
11
10
16
6073
|
|
VPR
QIIIYETYGDTW
44
11
17
27
6074
|
|
VPR
QIIIYNTYGDTW
44
11
13
20
6075
|
|
VPU
QRKIDRLI
49
8
21
33
6076
|
|
VPU
AKVDYRIVI
6
9
01
33
6077
|
|
VPU
RKILRQRKI
44
9
13
21
6078
|
|
VPU
LRQRKIDRL
47
9
17
27
6079
|
|
VPU
YRKILRQRKI
42
10
13
21
6080
|
|
VPU
#KKLLKQKKI
43
10
01
50
6081
|
|
VPU
LRQRKIDRLI
47
10
15
24
6082
|
|
VPU
RKIDRLIDRI
51
10
12
19
6083
|
|
VPU
QRKIDRLIDRI
49
11
12
19
6084
|
|
TABLE XIII
|
|
|
HIV B58 Super Motif Peptides
|
No. of
Sequence
Conservancy
|
Protein
Sequence
Position
Amino Acids
Frequency
(%)
SEQ ID NO.
|
|
ENV
NTSPRSRV
376
8
01
33
6085
|
|
ENV
NTSPRSRVAY
376
10
01
33
6086
|
|
ENV
TAGNSSRAAY
376
10
01
33
6087
|
|
ENV
TSNSSNSSTPI
160
11
01
33
6088
|
|
ENV
GTAGNSSRAAY
375
11
01
33
6089
|
|
ENV
IITEGNITL
478
8
01
50
6090
|
|
ENV
NANITIPCRI
478
10
01
50
6091
|
|
ENV
STRTIIREKRAV
586
11
01
50
6092
|
|
ENV
DSSNSTGNY
218
9
01
20
6093
|
|
ENV
SINGTETF
537
8
01
17
6094
|
|
ENV
NTETNKTETF
537
10
01
17
6095
|
|
ENV
NTTGNTTETF
537
10
01
17
6096
|
|
ENV
GSENGTETF
538
9
02
18
6097
|
|
ENV
NTRKSIRI
351
8
10
16
6098
|
|
ENV
SSLKGLRL
886
8
10
16
6099
|
|
ENV
SSLKGLRLGW
886
10
10
16
6100
|
|
ENV
CTPAGFAI
264
8
10
16
6101
|
|
ENV
QSSGGDPEI
423
9
10
16
6102
|
|
ENV
QSSGGDPEIV
423
10
10
16
6103
|
|
ENV
WSQELKNSAV
910
10
10
16
6104
|
|
ENV
FAILKCNDKKF
269
11
10
16
6105
|
|
ENV
RAVGIGAVF
594
9
11
17
6106
|
|
ENV
RAVGIGAVFL
594
10
11
17
6107
|
|
ENV
AARTVELL
876
8
11
17
6108
|
|
ENV
GTDRVIEV
932
8
11
17
6109
|
|
ENV
LALDKWASL
756
9
11
17
6110
|
|
ENV
IAARTVELL
874
9
11
17
6111
|
|
ENV
VSLLNATAI
919
9
11
17
6112
|
|
ENV
YATGDIIGDI
368
10
11
17
6113
|
|
ENV
TTNVPWNSSW
691
10
11
17
6114
|
|
ENV
LALDKWASLW
756
10
11
17
6115
|
|
ENV
ISNWLWYIKI
770
10
11
17
6116
|
|
ENV
RSIRLVNGFL
841
10
11
17
6117
|
|
ENV
CTTNVPWNSSW
690
11
11
17
6118
|
|
ENV
ISNWLWYIKIF
770
11
11
17
6119
|
|
ENV
SAVSLLNATAI
917
11
11
17
6120
|
|
ENV
VSLLNATAIAV
919
11
11
17
6121
|
|
ENV
RAVGIGAV
594
8
12
19
6122
|
|
ENV
EAQQIILLKL
646
9
12
19
6123
|
|
ENV
EAQQIILLKLTV
646
11
12
19
6124
|
|
ENV
RAMYAPPI
502
8
12
19
6125
|
|
ENV
GALFLGFL
601
8
12
19
6126
|
|
ENV
IAARTVEL
874
8
12
19
6127
|
|
ENV
PTRIRQGL
951
8
12
19
6128
|
|
ENV
ATGDIIGDI
369
9
12
19
6129
|
|
ENV
RSIRLVNGF
841
9
12
19
6130
|
|
ENV
MTWMEWEREI
721
10
12
19
6131
|
|
ENV
RAILHIPRRI
945
10
12
19
6132
|
|
ENV
PTDPNPQEVVL
89
11
12
19
6133
|
|
ENV
TSVITQACPKV
242
11
12
19
6134
|
|
ENV
GTCPCKNVSTV
281
11
12
19
6135
|
|
ENV
TTIISFNCRGEF
432
11
12
19
6136
|
|
ENV
CSGKLICTTTV
684
11
12
19
6137
|
|
ENV
ITKWLWYIKIF
770
11
12
19
6138
|
|
ENV
FSYHRLRDLLL
863
11
12
19
6139
|
|
ENV
LAEEEVVI
312
8
13
20
6140
|
|
ENV
GAMFLGFL
601
8
13
20
6141
|
|
ENV
RSIRLVSGF
841
9
13
20
6142
|
|
ENV
PTDPNPQEVV
89
10
13
20
6143
|
|
ENV
SAITQACPKV
243
10
13
20
6144
|
|
ENV
GSLAEEEVVI
310
10
13
20
6145
|
|
ENV
SSGGDPEIVM
424
10
13
20
6146
|
|
ENV
RSIRLVSGFL
841
10
13
20
6147
|
|
ENV
FSYIIRLRDFI
863
10
13
20
6148
|
|
ENV
TSAITQACPKV
242
11
13
20
6149
|
|
ENV
FSYIIRLRDFIL
863
11
13
20
6150
|
|
ENV
NAKTIIVQL
329
9
14
22
6151
|
|
ENV
QAMYAPPI
502
8
14
22
6152
|
|
ENV
ISNWLWYI
770
8
14
22
6153
|
|
ENV
GSLAEEEVV
310
9
14
22
6154
|
|
ENV
ITNWLWYIKI
770
10
14
22
6155
|
|
ENV
FSYIIRLRDLL
863
10
14
22
6156
|
|
ENV
IAVAEGIDRV
927
10
14
22
6157
|
|
ENV
ITNWLWYIKIF
770
11
14
22
6158
|
|
ENV
IAVAEGTDRVI
927
11
14
22
6159
|
|
ENV
ITKWLWYIKI
770
10
15
23
6160
|
|
ENV
ITLPCRIKQII
483
11
15
23
6161
|
|
ENV
IAVAEGTDRII
927
11
15
23
6162
|
|
ENV
GSLAEEEV
310
8
16
25
6163
|
|
ENV
SSGGDLEI
424
8
16
25
6164
|
|
ENV
ITKWLWYI
770
8
16
25
6165
|
|
ENV
VAEGTDRV
929
8
16
25
6166
|
|
ENV
HSFNCRGEF
434
9
16
25
6167
|
|
ENV
VSGFLALAW
846
9
16
25
6168
|
|
ENV
VAEGTDRVI
929
9
16
25
6169
|
|
ENV
IISFNCRGEFF
434
10
16
25
6170
|
|
ENV
IAVAEGTDRI
927
10
16
25
6171
|
|
ENV
TTHSFNCGGEF
432
11
16
25
6172
|
|
ENV
IISFNCRGEFFY
434
11
16
25
6173
|
|
ENV
GTCPCKNV
281
8
17
27
6174
|
|
ENV
DAKAYDTEV
70
9
17
27
6175
|
|
ENV
ASLWNWFDI
762
9
17
27
6176
|
|
ENV
KAYDTEVIINV
72
10
17
27
6177
|
|
ENV
VAPTKAKRRV
574
10
17
27
6178
|
|
ENV
WASLWNWFDI
761
10
17
27
6179
|
|
ENV
ASDAKAYDTEV
68
11
17
27
6180
|
|
ENV
KAYDTEVIINVW
72
11
17
27
6181
|
|
ENV
VAPTKAKRRVV
574
11
17
27
6182
|
|
ENV
CSGKLICTTNV
684
11
17
27
6183
|
|
ENV
SSGGDPEIV
424
9
18
28
6184
|
|
ENV
FSYIIRLRDF
863
9
18
28
6185
|
|
ENV
VAEGTDRII
929
9
18
28
6186
|
|
ENV
DTEVIINVW
75
8
19
30
6187
|
|
ENV
SSNITGLL
516
8
19
30
6188
|
|
ENV
ITNWLWYI
770
8
19
30
6189
|
|
ENV
VAEGTDRI
929
8
19
30
6190
|
|
ENV
CSSNIIGLL
515
9
19
30
6191
|
|
ENV
SSNITGLLL
516
9
19
30
6192
|
|
ENV
CSSNITGLLL
515
10
19
30
6193
|
|
ENV
CSGKLICTTAV
684
11
19
30
6194
|
|
ENV
LALAWDDLRSL
850
11
19
30
6195
|
|
ENV
LAWDDLRSL
852
9
20
31
6196
|
|
ENV
LAWDDLRSLCL
852
11
20
31
6197
|
|
ENV
CSSNITGL
515
8
21
33
6198
|
|
ENV
PTDPNPQEV
89
9
21
33
6199
|
|
ENV
ETFRPGGGDM
544
10
21
33
6200
|
|
ENV
PTKAKRRV
576
8
22
34
6201
|
|
ENV
GAVFLGFL
601
8
22
34
6202
|
|
ENV
PTKAKKRVV
576
9
22
34
6203
|
|
ENV
KAMYAPPI
502
8
23
36
6204
|
|
ENV
FSYIIRLRDL
863
9
23
36
6205
|
|
ENV
SSGGDPEI
424
8
24
38
6206
|
|
ENV
LALAWDDL
850
8
25
39
6207
|
|
ENV
PTDPNPQEI
89
9
25
39
6208
|
|
ENV
ITLPCRIKQI
483
10
25
39
6209
|
|
ENV
LSGIVQQQNNL
631
11
25
39
6210
|
|
ENV
CTIIGIRPV
294
8
26
41
6211
|
|
ENV
QSNLLRAI
638
8
26
41
6212
|
|
ENV
CTIIGIRPYV
294
9
26
41
6213
|
|
ENV
ITLTVQARQL
621
10
27
42
6214
|
|
ENV
ITLTVQARQLL
621
11
27
42
6215
|
|
ENV
VSFEPIPIHY
253
10
28
44
6216
|
|
ENV
YSPLSFQTL
807
9
29
46
6217
|
|
ENV
CAPAGFAI
264
8
29
45
6218
|
|
ENV
CAPAGFAIL
264
9
29
45
6219
|
|
ENV
ITQACPKVSF
245
10
29
45
6220
|
|
ENV
VSFEPIPI
253
8
30
47
6221
|
|
ENV
WASLWNWF
761
8
30
47
6222
|
|
ENV
QACPKVSFEPI
248
11
30
47
6223
|
|
ENV
FAYLSIVNRY
794
10
31
48
6224
|
|
ENV
RSLCLFSYIIRL
858
11
31
48
6225
|
|
ENV
CTHGIKPVY
294
9
32
50
6226
|
|
ENV
LSGIVQQQSNL
631
11
32
50
6227
|
|
ENV
CTHGIKPY
294
8
33
52
6228
|
|
ENV
QARYLAVERY
663
10
33
52
6229
|
|
ENV
QARYLAYERYL
663
11
33
52
6230
|
|
ENV
EAQQHLLQLTV
646
11
34
54
6231
|
|
ENV
VTENFNMW
102
8
34
53
6232
|
|
ENV
AAGSTMGAASI
611
11
34
53
6233
|
|
ENV
LSIYNRVRQGY
797
11
34
53
6234
|
|
ENV
EAQQIILLQL
646
9
35
56
6235
|
|
ENV
RSLCLFSY
858
8
35
55
6236
|
|
ENV
IISFNCGGIEFF
434
10
35
55
6237
|
|
ENV
IISFNCGGEFFY
434
11
35
55
6238
|
|
ENV
AASITLTV
618
8
36
56
6239
|
|
ENV
IISFNCGGFW
434
9
36
56
6240
|
|
ENV
GAASITLTV
617
9
36
56
6241
|
|
ENV
LTVQARQLL
623
9
36
56
6242
|
|
ENV
ITQACPKV
245
8
37
58
6243
|
|
ENV
LTVQARQL
623
8
38
59
6244
|
|
ENV
QARQLLSGI
626
9
38
59
6245
|
|
ENV
QARQLLSGIV
626
10
38
59
6246
|
|
ENV
STMGAASI
614
8
39
61
6247
|
|
ENV
GSTMGAASI
613
9
39
61
6248
|
|
ENV
STMGAASITL
614
10
39
61
6249
|
|
ENV
GSTMGAASITL
613
11
39
61
6250
|
|
ENV
QACPKVSF
248
8
40
63
6251
|
|
ENV
CASDAKAY
67
8
42
66
6252
|
|
ENV
RAIEAQQIILL
643
10
44
69
6253
|
|
ENV
RAIEAQQIIL
643
9
45
70
6254
|
|
ENV
ISLWDQSL
122
8
48
75
6255
|
|
ENV
QSLKPCVKL
127
9
48
75
6256
|
|
ENV
RSELYKYKVV
558
10
49
77
6257
|
|
ENV
RSELYKYKV
558
9
50
78
6258
|
|
ENV
STVQCTIIGI
289
9
51
80
6259
|
|
ENV
VSTVQCTFIGI
288
10
51
80
6260
|
|
ENV
LTPLCVTL
135
8
54
84
6261
|
|
ENV
VTVYYGVPV
47
9
55
86
6262
|
|
ENV
VTVYYGVPVW
47
10
55
86
6263
|
|
ENV
STQLLLNGSL
303
10
57
89
6264
|
|
ENV
VSTQLLLNGSL
302
11
57
89
6265
|
|
ENV
LTVWGIKQL
654
9
59
92
6266
|
|
GAG
TAPPPESF
508
8
01
33
6267
|
|
GAG
ETIDKDLY
537
8
01
25
6268
|
|
GAG
PTAPPPESF
507
9
01
33
6269
|
|
GAG
TAPPPESFRF
508
10
01
33
6270
|
|
GAG
ETIDKDLYPL
537
10
01
25
6271
|
|
GAG
RTENSLYPPL
538
10
01
25
6272
|
|
GAG
AAAIMMQKSNF
405
11
01
25
6273
|
|
GAG
SATIMMQRGNF
405
11
01
25
6274
|
|
GAG
PTAPPPESFRF
507
11
01
33
6275
|
|
GAG
GAAAATDSNI
123
10
01
50
6276
|
|
GAG
AADKGVSQNY
130
10
01
50
6277
|
|
GAG
AAGTGNSSQV
130
10
01
50
6278
|
|
GAG
GANSIPVGDI
276
10
01
50
6279
|
|
GAG
SAQQDLKGGY
393
10
01
50
6280
|
|
GAG
TAQQDLKGGY
393
10
01
50
6281
|
|
GAG
GANSIPVGDIY
276
11
01
50
6282
|
|
GAG
ASAQQDLKGGY
392
11
01
50
6283
|
|
GAG
ATAQQDLKGGY
392
11
01
50
6284
|
|
GAG
PAEPTAPPAEI
492
11
01
50
6285
|
|
GAG
TAPPAESF
508
8
02
67
6286
|
|
GAG
PTAPPAESF
507
9
02
67
6287
|
|
GAG
TAPPAESFRF
508
10
02
67
6288
|
|
GAG
PTAPPAESFRF
507
11
02
67
6289
|
|
GAG
GTRPGNYV
480
8
02
00
6290
|
|
GAG
AADKGKVSQNY
129
11
02
18
6291
|
|
GAG
AADGKVSQNY
129
10
04
36
6292
|
|
GAG
AAIMMQKSNF
406
10
06
15
6293
|
|
GAG
TTPSQKQEPI
522
10
09
45
6294
|
|
GAG
GASLEEMM
364
8
10
16
6295
|
|
GAG
DTKEALEKI
98
9
10
16
6296
|
|
GAG
TAPPAESFGF
496
10
10
16
6297
|
|
GAG
QALSPRTLNAW
166
11
10
16
6298
|
|
GAG
PTAPPAESFGF
495
11
10
16
6299
|
|
GAG
AIIMMQRGNF
406
10
11
28
6300
|
|
GAG
PSQKQEPI
528
8
11
18
6301
|
|
GAG
SSKGRPGNF
476
9
11
18
6302
|
|
GAG
TTSTLQEQIAW
260
11
11
17
6303
|
|
GAG
QALSPRTL
166
8
11
17
6304
|
|
GAG
ASQEVKNW
333
8
11
17
6305
|
|
GAG
ASVLSGGEL
5
9
11
17
6306
|
|
GAG
QASQEVKNW
332
9
11
17
6307
|
|
GAG
ASQEVKNWM
333
9
11
17
6308
|
|
GAG
NANPDCKSI
349
9
11
17
6309
|
|
GAG
RASVLSGGEL
4
10
11
17
6310
|
|
GAG
QASQEVKNWM
332
10
11
17
6311
|
|
GAG
NANPDCKSIL
349
10
11
17
6312
|
|
GAG
PSSKGRPGNF
475
10
11
17
6313
|
|
GAG
QTGSEELRSL
71
10
12
19
6314
|
|
GAG
GSEELKSL
73
8
12
19
6315
|
|
GAG
GIEELRSL
73
8
12
19
6316
|
|
GAG
ATPQDLNM
200
8
12
19
6317
|
|
GAG
LTSLRSLF
549
8
12
19
6318
|
|
GAG
GSEELRSLY
73
9
12
19
6319
|
|
GAG
GATPQDLNM
199
9
12
19
6320
|
|
GAG
ATPQDLNMM
200
9
12
19
6321
|
|
GAG
STLQEQIAW
262
9
12
19
6322
|
|
GAG
RAEQASQEV
329
9
12
19
6323
|
|
GAG
KSLIGNDPL
553
9
12
19
6324
|
|
GAG
ATLYCVHQKI
85
10
12
19
6325
|
|
GAG
GATPQDLNMM
199
10
12
19
6326
|
|
GAG
ATPQDLNMML
200
10
12
19
6327
|
|
GAG
TSTLQEQIAW
261
10
12
19
6328
|
|
GAG
STLQEQIAWM
262
10
12
19
6329
|
|
GAG
VATLYCVIIQKI
84
11
12
19
6330
|
|
GAG
GATPQDLNMML
199
11
12
19
6331
|
|
GAG
TSTLQEQIAWM
261
11
12
19
6332
|
|
GAG
TSNPPIPVGEI
272
11
12
19
6333
|
|
GAG
LTSLKSLF
549
8
13
20
6334
|
|
GAG
YSPTSILDI
301
9
13
20
6335
|
|
GAG
PSLQTGSEEL
68
10
13
20
6336
|
|
GAG
NSSQVSQNY
144
9
14
31
6337
|
|
GAG
NSSQVSQNYPI
144
11
14
31
6338
|
|
GAG
TSEGCRQIL
55
9
14
22
6339
|
|
GAG
ETSEGCRQIL
54
10
14
22
6340
|
|
GAG
AAEWDRVHPV
230
10
14
22
6341
|
|
GAG
PSNKGRPGNF
475
10
14
22
6342
|
|
GAG
TAPPEESFRF
496
10
14
22
6343
|
|
GAG
EAAEWDRVIIPV
229
11
14
22
6344
|
|
GAG
PTAPPEESFRP
495
11
14
22
6345
|
|
GAG
SSQVSQNY
145
8
15
31
6346
|
|
GAG
SSQVSQNYPI
145
10
15
31
6347
|
|
GAG
SSQVSQNYPIV
145
11
15
31
6348
|
|
GAG
RSLYNTVATL
78
10
15
24
6349
|
|
GAG
RSLYNTVATLY
78
11
15
24
6350
|
|
GAG
EAAEWDRV
229
8
15
23
6351
|
|
GAG
ATQDVKNW
333
8
15
23
6352
|
|
GAG
TAPPEESF
496
8
15
23
6353
|
|
GAG
LASLKSLF
549
8
15
23
6354
|
|
GAG
RAEQATQDV
329
9
15
23
6355
|
|
GAG
QAIQDVKNW
332
9
15
23
6356
|
|
GAG
AIQDVKNWM
333
9
15
23
6357
|
|
GAG
PTAPPEESF
495
9
15
23
6358
|
|
GAG
ATLYCVIIQRI
85
10
15
23
6359
|
|
GAG
QATQDVKNWM
332
10
15
23
6360
|
|
GAG
VATLYCVIIQRI
84
11
15
23
6361
|
|
GAG
FAVNPGLL
46
8
16
25
6362
|
|
GAG
TSEGCRQI
55
8
16
25
6363
|
|
GAG
GSEELRSL
73
8
16
25
6364
|
|
GAG
TSNPPIPV
272
8
16
25
6365
|
|
GAG
PAATLEEM
363
8
16
25
6366
|
|
GAG
AATLEEMM
364
8
16
25
6367
|
|
GAG
LSGGKLDAW
8
9
16
25
6368
|
|
GAG
ETSEGCRQI
54
9
16
25
6369
|
|
GAG
MTSNPPIPV
271
9
16
25
6370
|
|
GAG
KALGPAATL
359
9
16
25
6371
|
|
GAG
PAATLEEMM
363
9
16
25
6372
|
|
GAG
DAWEKIRL
14
8
17
27
6373
|
|
GAG
LSPRTLNAW
168
9
17
27
6374
|
|
GAG
ASRELERFAV
38
10
17
27
6375
|
|
GAG
LSPRTLNAWV
168
10
17
27
6376
|
|
GAG
HAGPIPPGQM
240
10
17
27
6377
|
|
GAG
WASRELERFAY
37
11
17
27
6378
|
|
GAG
ATQEVKNW
333
8
18
28
6379
|
|
GAG
QATQEVKNW
332
9
18
28
6380
|
|
GAG
ATQEVKNWM
333
9
18
28
6381
|
|
GAG
HAGPIAPGQM
240
10
18
28
6382
|
|
GAG
QATQEVKNWM
332
10
18
28
6383
|
|
GAG
PSHKARVL
380
8
19
30
6384
|
|
GAG
TAPPAESF
496
8
20
31
6385
|
|
GAG
MTNNPPIPV
271
9
20
31
6386
|
|
GAG
PTAPPAESF
495
9
20
31
6387
|
|
GAG
FALNPGLL
46
8
22
34
6388
|
|
GAG
ASRELERFAL
38
10
22
34
6389
|
|
GAG
ETINEEAAEW
224
10
22
34
6390
|
|
GAG
WASRELERFAL
37
11
22
34
6391
|
|
GAG
PSIIKGRPGNF
475
10
23
36
6392
|
|
GAG
PSIIKGRPGNFL
475
11
23
36
6393
|
|
GAG
AAMQMLKETI
217
10
26
41
6394
|
|
GAG
QAAMQMLKETI
216
11
26
41
6395
|
|
GAG
TTSTLQEQIGW
260
11
27
43
6396
|
|
GAG
STLQEQIGW
262
9
27
42
6397
|
|
GAG
RAEQATQEV
329
9
27
42
6398
|
|
GAG
TSTLQEQIGW
261
10
27
42
6399
|
|
GAG
STLQEQIGWM
262
10
27
42
6400
|
|
GAG
TSTLQEQIGWM
261
11
27
42
6401
|
|
GAG
VSQNYPIVQNL
149
11
28
48
6402
|
|
GAG
ASVLSGGKL
5
9
28
44
6403
|
|
GAG
RASVLSGGKL
4
10
28
44
6404
|
|
GAG
QAISPRTL
166
8
29
45
6405
|
|
GAG
GATLEEMM
364
8
29
45
6406
|
|
GAG
QAISPRTLNAW
166
11
29
45
6407
|
|
GAG
RTLNAWVKVI
171
10
30
47
6408
|
|
GAG
RTLNAWVKVV
171
10
31
48
6409
|
|
GAG
DTINEEAAEW
224
10
31
48
6410
|
|
GAG
DTKEALDKI
98
9
32
50
6411
|
|
GAG
AAMQMLKDTI
217
10
33
52
6412
|
|
GAG
QAAMQMLKDTI
216
11
33
52
6413
|
|
GAG
AAEWDRLIIPV
230
10
34
53
6414
|
|
GAG
EAAEWDRLIIPV
229
11
34
53
6415
|
|
GAG
LAEAMSQV
387
8
36
57
6416
|
|
GAG
ISPRTLNAW
168
9
36
56
6417
|
|
GAG
ISPRTLNAWV
168
10
36
56
6418
|
|
GAG
EAAEWDRL
229
8
39
61
6419
|
|
GAG
YSPVSILDI
301
9
40
63
6420
|
|
GAG
NTVATLYCV
82
9
41
64
6421
|
|
GAG
ATPQDLNIM
200
9
42
66
6422
|
|
GAG
GATPQDLNTM
199
10
42
66
6423
|
|
GAG
ATPQDLNTML
200
10
42
66
6424
|
|
GAG
GATPQDLNTML
199
11
42
66
6425
|
|
GAG
TTSTLQEQI
260
9
45
71
6426
|
|
GAG
NANPDCKTI
349
9
45
70
6427
|
|
GAG
GTTSTLQEQI
259
10
45
70
6428
|
|
GAG
NANPDCKTIL
349
10
45
70
6429
|
|
GAG
ASRELERF
38
8
46
72
6430
|
|
GAG
WASRELERF
37
9
46
72
6431
|
|
GAG
TSTLQEQI
261
8
47
73
6432
|
|
GAG
NTVGGIIQAAM
210
10
47
73
6433
|
|
GAG
GSDIAGTTSTL
254
11
47
73
6434
|
|
GAG
VSQNYPIV
149
8
48
83
6435
|
|
GAG
IAGTTSTL
257
8
48
75
6436
|
|
GAG
KAFSPEVI
183
8
50
78
6437
|
|
GAG
KAFSPEVIFM
183
10
50
78
6438
|
|
GAG
KAFSPEVIFMF
183
11
50
78
6439
|
|
GAG
RAPRKKGCW
439
9
53
83
6440
|
|
GAG
FSPEVIFM
185
8
54
84
6441
|
|
GAG
ISPEVIFMF
185
9
54
84
6442
|
|
GAG
CTERQANF
459
8
55
87
6443
|
|
GAG
CTERQANFL
459
9
55
87
6444
|
|
GAG
QANFLGKI
466
8
57
89
6445
|
|
GAG
KARVLAEAM
383
9
57
89
6446
|
|
GAG
QANFLGKIW
466
9
57
89
6447
|
|
GAG
LSEGATPQDL
196
10
58
91
6448
|
|
GAG
RTLNAWVKV
171
9
61
95
6449
|
|
NEF
QAIEPAAAGV
34
9
01
33
6450
|
|
NEF
QTEPAAVGV
32
9
01
17
6451
|
|
NEF
RAEPAADGV
32
9
01
17
6452
|
|
NEF
RTEPAAVGV
32
9
01
17
6453
|
|
NEF
QAEPAAEGV
33
9
01
17
6454
|
|
NEF
QAPTAAKGV
33
9
01
17
6455
|
|
NEF
RAQAEPAAAGV
32
11
01
17
6456
|
|
NEF
GAFDLSPF
110
8
10
16
6457
|
|
NEF
GAFDLSFFL
110
9
10
16
6458
|
|
NEF
MARELIIPEY
321
9
10
16
6459
|
|
NEF
MARELIIPEYY
321
10
10
16
6460
|
|
NEF
AADGVGAV
42
8
11
18
6461
|
|
NEF
PAADGVGAV
41
9
11
17
6462
|
|
NEF
VSRDLEKIIGAI
49
11
11
17
6463
|
|
NEF
ATNADCAW
71
8
12
22
6464
|
|
NEF
AATNADCAW
70
9
12
22
6465
|
|
NEF
ATNADCAWL
71
9
12
22
6466
|
|
NEF
AATNADCAWL
70
10
12
22
6467
|
|
NEF
PAAEGVGAV
41
9
12
19
6468
|
|
NEF
MTYKGAFDL
106
9
12
19
6469
|
|
NEF
NIQGYFPDW
194
9
12
19
6470
|
|
NEF
TAATNADCAW
69
10
12
19
6471
|
|
NEF
GTRFPLTFGW
213
10
12
19
6472
|
|
NEF
NTAATNADCAW
68
11
12
19
6473
|
|
NEF
TAATNADCAWL
69
11
12
19
6474
|
|
NEF
GTRFPLTF
213
8
13
20
6475
|
|
NEF
YTPGPGTRF
207
9
13
20
6476
|
|
NEF
YTPGPGTRFPL
207
11
13
20
6477
|
|
NEF
HTQGFFPDW
194
9
14
22
6478
|
|
NEF
EAQEEEEV
82
8
16
25
6479
|
|
NEF
EAQEEEEVGF
82
10
16
25
6480
|
|
NEF
YTPGPGTRYPL
207
11
16
25
6481
|
|
NEF
AAEGVGAV
42
8
17
28
6482
|
|
NEF
YTPGPGIRY
207
9
17
27
6483
|
|
NEF
WSKSSIVGW
5
9
20
31
6484
|
|
NEF
YSKKRQEI
176
8
22
34
6485
|
|
NEF
YSKKRQEIL
176
9
22
34
6486
|
|
NEF
LSFFLKEKGGI
114
11
22
34
6487
|
|
NEF
YSKKRQEILDL
176
11
22
34
6488
|
|
NEF
IITQGYFPDW
194
9
25
39
6489
|
|
NEF
LSIIFLKEKGGL
114
11
27
42
6490
|
|
NEF
LTFGWCFKLV
221
10
35
55
6491
|
|
NEF
LTFGWCFKL
221
9
39
61
6492
|
|
POL
NSPTSREL
34
8
01
33
6493
|
|
POL
PTSRELQV
36
8
01
33
6494
|
|
POL
GTLNCPQI
80
8
01
33
6495
|
|
POL
PTFNFPQI
80
8
01
33
6496
|
|
POL
STNSPTSREL
32
10
01
33
6497
|
|
POL
NSPTSRELQV
34
10
01
33
6498
|
|
POL
RANSPSSREL
35
10
01
33
6499
|
|
POL
GTLNCPQITL
80
10
01
33
6500
|
|
POL
PTPNFPQITL
80
10
01
33
6501
|
|
POL
NSTNSPTSREL
31
11
01
33
6502
|
|
POL
GTLNCPQITLW
80
11
01
33
6503
|
|
POL
PTFNFPQITLW
80
11
01
33
6504
|
|
POL
NSPSSREL
37
8
01
50
6505
|
|
POL
NSPTTREL
39
8
01
50
6506
|
|
POL
PSSRELQV
39
8
01
50
6507
|
|
POL
NSPSSRELQV
37
10
01
50
6508
|
|
POL
RANSPTTREL
37
10
01
50
6509
|
|
POL
NSPTTRELQV
39
10
01
50
6510
|
|
POL
GADRQGIV
70
8
01
20
6511
|
|
POL
GSGRAVPI
70
8
01
20
6512
|
|
POL
GADRQGIVSF
70
10
01
20
6513
|
|
POL
GSGRAVPICL
70
10
01
20
6514
|
|
POL
GTTLNFPQI
79
9
01
17
6515
|
|
POL
GAISLSLPQI
79
10
01
17
6516
|
|
POL
GTTLNPPQITF
79
11
01
17
6517
|
|
POL
PSLSFPQI
79
8
02
33
6518
|
|
POL
PSLSFPQIIL
79
10
02
33
6519
|
|
POL
PSLSFPQIILW
79
11
02
33
6520
|
|
POL
SSFSFPQI
82
8
03
30
6521
|
|
POL
SSFSFPQITL
82
10
03
30
6522
|
|
POL
SSFSFPQITLW
82
11
03
30
6523
|
|
POL
VSFSFPQITLW
78
11
07
15
6524
|
|
POL
VSFSFPQI
78
8
08
17
6525
|
|
POL
VSFSFPQITL
78
10
08
17
6526
|
|
POL
ETWWTDYW
591
8
10
16
6527
|
|
POL
RANSPTSREL
26
10
10
16
6528
|
|
POL
ETWETWWTDY
588
10
10
16
6529
|
|
POL
ETWETWWTEY
588
10
10
16
6530
|
|
POL
QTKELQKQII
961
10
10
16
6531
|
|
POL
LAFPQGEAREF
6
11
10
16
6532
|
|
POL
RSAIITNDVKQL
550
11
10
16
6533
|
|
POL
EAVQKIATESI
562
11
10
16
6534
|
|
POL
ETWETWWTDYW
588
11
10
16
6535
|
|
POL
RTAHTNDV
550
8
11
17
6536
|
|
POL
WAGIQQEF
884
8
11
17
6537
|
|
POL
VTVKIGGQL
98
9
11
17
6538
|
|
POL
STNNETPGI
323
9
11
17
6539
|
|
POL
GTKALTEVI
474
9
11
17
6540
|
|
POL
GSNFTSTTV
870
9
11
17
6541
|
|
POL
GADDTVLEEM
114
10
11
17
6542
|
|
POL
ISRIGPENPY
236
30
11
17
6543
|
|
POL
PSTNNETPGI
322
10
11
17
6544
|
|
POL
TAIITNDVKQL
551
10
11
17
6545
|
|
POL
WAGIQQEFGI
884
10
11
17
6546
|
|
POL
STNNETPGIRY
323
11
11
17
6547
|
|
POL
ESWTVNDIQKL
439
11
11
17
6548
|
|
POL
GTKALTEVIFL
474
11
11
17
6549
|
|
POL
ESWTVNDI
439
8
12
19
6550
|
|
POL
KTELQAIY
668
8
12
19
6551
|
|
POL
KTELQAIYL
668
9
12
19
6552
|
|
POL
NSPTRRELQVW
28
11
12
19
6553
|
|
POL
TTNQKTELIIAI
664
11
12
19
6554
|
|
POL
KTELQAIYLAL
668
11
12
19
6555
|
|
POL
GAVVIQINSEI
999
11
12
19
6556
|
|
POL
KTGKYARM
542
8
13
21
6557
|
|
POL
WTVQPIVL
428
8
13
20
6558
|
|
POL
PTRRELQVW
30
9
13
20
6559
|
|
POL
DTVLEDINL
117
9
13
20
6560
|
|
POL
NSPTRRELQV
28
10
13
20
6561
|
|
POL
LAGRWPVKTI
856
10
13
20
6562
|
|
POL
RAKIEELREIIL
388
11
13
20
6563
|
|
POL
IATESIVI
567
8
14
22
6564
|
|
POL
IATESIVIW
567
9
14
22
6565
|
|
POL
NSPTSREL
28
8
14
22
6566
|
|
POL
PTRRELQV
30
8
14
22
6567
|
|
POL
FSFPQITLW
85
9
14
22
6568
|
|
POL
DTVLEEINL
117
9
14
22
6569
|
|
POL
WTDYWQATW
594
9
14
22
6570
|
|
POL
SAGERIVDI
947
9
14
22
6571
|
|
POL
ASDIQTKEL
957
9
14
22
6572
|
|
POL
WTDYWQAIWI
594
10
14
22
6573
|
|
POL
TSTTVKAACW
874
10
14
22
6574
|
|
POL
YSAGERIVDI
946
10
14
22
6575
|
|
POL
SAGERIYDII
947
10
14
22
6576
|
|
POL
IASDIQTKEL
956
10
14
22
6577
|
|
POL
RTKIEELRQIIL
388
11
14
22
6578
|
|
POL
FTSTTVKAACW
873
11
14
22
6579
|
|
POL
TSTTVKAACWW
874
11
14
22
6580
|
|
POL
YSAGERIVDII
946
11
14
22
6581
|
|
POL
KALVEICTEM
219
10
15
24
6582
|
|
POL
FSFPQITL
85
8
15
23
6583
|
|
POL
LTQLGCTL
377
8
15
23
6584
|
|
POL
RSAIITNDV
550
8
15
23
6585
|
|
POL
VSAGIRKV
744
8
15
23
6586
|
|
POL
SAGIRKVL
745
8
15
23
6587
|
|
POL
ITVKAACW
876
8
15
23
6588
|
|
POL
KTELQAIIIL
668
9
15
23
6589
|
|
POL
VSAGIRKVL
744
9
15
23
6590
|
|
POL
SAGIRKVLF
745
9
15
23
6591
|
|
POL
STTVKAACW
875
9
15
23
6592
|
|
POL
TTVKAACWW
876
9
15
23
6593
|
|
POL
GADDTVLEDI
114
10
15
23
6594
|
|
POL
LTQLGCTLNF
177
10
15
23
6595
|
|
POL
LTEEKIKALV
213
10
15
23
6596
|
|
POL
VSAGIRKVLF
744
10
15
23
6597
|
|
POL
SAGIRKVLFL
745
10
15
23
6598
|
|
POL
STTVKAACWW
875
10
15
23
6599
|
|
POL
KTELQAIIILAL
668
11
15
23
6600
|
|
POL
VSAGIRKVLFL
744
11
15
23
6601
|
|
POL
KAQEEIIERY
759
9
16
25
6602
|
|
POL
YSAGERIV
946
8
16
25
6603
|
|
POL
KALTEVIFL
476
9
16
25
6604
|
|
POL
RANSPTRREL
26
10
16
25
6605
|
|
POL
SAIITNDVKQL
551
10
16
25
6606
|
|
POL
NSPIRREL
28
8
17
27
6607
|
|
POL
VTIKIGGQL
98
9
17
27
6608
|
|
POL
KTPKFKLPI
577
9
17
27
6609
|
|
POL
GAKALTDIYPL
474
11
17
27
6610
|
|
POL
FSVPLDKDF
305
9
18
28
6611
|
|
POL
YAGIKVKQL
460
9
18
28
6612
|
|
POL
GADDTVLEELI
114
10
18
28
6613
|
|
POL
ITLWQRPLVTV
90
11
18
28
6614
|
|
POL
KIGKYAKM
542
8
19
30
6615
|
|
POL
GTKALTEV
474
8
19
30
6616
|
|
POL
ATESIVIW
568
8
19
30
6617
|
|
POL
GAIITNDVKQL
551
10
19
30
6618
|
|
POL
KSESELVNQI
704
10
19
30
6619
|
|
POL
KSESELVSQI
704
10
19
30
6620
|
|
POL
ITLWQRPLVTI
90
11
19
30
6621
|
|
POL
LTDTTNQKTEL
661
11
19
30
6622
|
|
POL
KSESELVNQII
704
11
19
30
6623
|
|
POL
KSESELVSQII
704
11
19
30
6624
|
|
POL
VSQIIEQL
710
8
20
31
6625
|
|
POL
VSQIIEQLI
710
9
20
31
6626
|
|
POL
MASDFNLPPIV
774
11
20
31
6627
|
|
POL
ESELVSQI
706
8
21
33
6628
|
|
POL
WAGIKQEF
884
8
21
33
6629
|
|
POL
KALTDIVPL
476
9
21
33
6630
|
|
POL
ESELVSQII
706
9
21
33
6631
|
|
POL
ASDFNLPPIV
775
10
21
33
6632
|
|
POL
WAGIKQEFGI
884
10
21
33
6633
|
|
POL
LAWVPAIIKGI
725
10
22
34
6634
|
|
POL
MASDFNLPPI
774
10
22
34
6635
|
|
POL
LAGRWPVKVI
856
10
22
34
6636
|
|
POL
ASDFNLPPI
775
9
23
36
6637
|
|
POL
CTIILEGKVIL
817
10
23
36
6638
|
|
POL
CTIILEGKVILV
817
11
23
36
6639
|
|
POL
GAKALTDIV
474
9
24
38
6640
|
|
POL
WTEYWQATW
594
9
24
38
6641
|
|
POL
WTEYWQATWI
594
10
24
38
6642
|
|
POL
PTPVNIIGRNM
166
11
24
38
6643
|
|
POL
GAKALTDI
474
8
25
39
6644
|
|
POL
DSGSEVNI
680
8
25
39
6645
|
|
POL
DSGSEVNIV
680
9
25
39
6646
|
|
POL
ASCWNLPPV
775
9
25
39
6647
|
|
POL
LALQDSGSEV
676
10
25
39
6648
|
|
POL
SSGIRKVLFL
745
10
25
39
6649
|
|
POL
MASDFNLPPV
774
10
25
39
6650
|
|
POL
ASDFNLPPV
775
10
25
39
6651
|
|
POL
LTETTNQKTEL
661
11
25
39
6652
|
|
POL
VSSGIRKVLFL
744
11
25
39
6653
|
|
POL
MASDFNLPPVV
774
11
25
39
6654
|
|
POL
ASQIYAGIKV
456
10
26
41
6655
|
|
POL
VSSGIRKV
744
8
26
41
6656
|
|
POL
SSGIRKVL
745
8
26
41
6657
|
|
POL
CTIILEGKV
817
8
26
41
6658
|
|
POL
PSKDLIAEI
513
9
26
41
6659
|
|
POL
DTTNQKTEL
663
9
26
41
6660
|
|
POL
VSSGIRKVL
744
9
26
41
6661
|
|
POL
SSGIRKVLF
745
9
26
41
6662
|
|
POL
CTIILEGKVI
817
9
26
41
6663
|
|
POL
GSNFTSAAV
870
9
26
41
6664
|
|
POL
VSSGIRKVLI
744
10
26
41
6665
|
|
POL
ETGQETAYFL
844
10
26
41
6666
|
|
POL
PTPVNIIGRNL
166
11
26
41
6667
|
|
POL
WASQIYAGIKV
455
11
26
41
6668
|
|
POL
ETGQETAYFLL
844
11
26
41
6669
|
|
POL
ASQIVAGI
456
8
27
43
6670
|
|
POL
KAQEEIIEKY
759
9
27
43
6671
|
|
POL
ASQIYPGIKV
456
10
27
43
6672
|
|
POL
LALQDSGL
676
8
27
42
6673
|
|
POL
ESELVNQI
706
8
27
42
6674
|
|
POL
TAYFLLKL
849
8
27
42
6675
|
|
POL
WASQIYAGI
455
9
27
42
6676
|
|
POL
ESELVNQI
706
9
27
42
6677
|
|
POL
ETAYFLLKL
848
9
27
42
6678
|
|
POL
CTEMEKEGKI
225
10
27
42
6679
|
|
POL
LALQDSGLEV
676
10
27
42
6680
|
|
POL
TSAAVKAACW
874
10
27
42
6681
|
|
POL
WASQIYPGIKV
455
11
27
42
6682
|
|
POL
FTSAAVKAACW
873
11
27
42
6683
|
|
POL
TSAAVKAACWW
874
11
27
42
6684
|
|
POL
WTVQPIQL
428
8
28
44
6685
|
|
POL
DSGLEVNI
680
8
28
44
6686
|
|
POL
AAVKAACW
816
8
28
44
6687
|
|
POL
DSGLEVNIV
680
9
28
44
6688
|
|
POL
SAAVKAACW
875
9
28
44
6689
|
|
POL
AAVKAACWW
876
9
28
44
6690
|
|
POL
VTDRGRQKVV
650
10
28
44
6691
|
|
POL
SAAVKAACWW
875
10
28
44
6692
|
|
POL
ASQIYPGI
456
8
29
46
6693
|
|
POL
WASQIYPGI
455
9
29
45
6694
|
|
POL
KTPKPRLPI
577
9
29
45
6695
|
|
POL
ETTNQKTEL
663
9
29
45
6696
|
|
POL
AANRETKL
637
8
30
47
6697
|
|
POL
GAANRETKL
636
9
30
47
6698
|
|
POL
VTDRGRQKV
650
9
30
47
6699
|
|
POL
LAGRWPVKV
856
9
30
47
6700
|
|
POL
KAACWWAGI
879
9
31
49
6701
|
|
POL
ETAYFILKL
848
9
31
48
6702
|
|
POL
PSINNETPGI
322
10
31
48
6703
|
|
POL
CTIILEGKIIL
817
10
31
48
6704
|
|
POL
ETGQETAYFI
844
10
31
48
6705
|
|
POL
CTHLEGKIILV
817
11
31
48
6706
|
|
POL
ETGQETAYFIL
844
11
31
48
6707
|
|
POL
TAYFILKL
849
8
32
50
6708
|
|
POL
AACWWAGI
880
8
32
50
6709
|
|
POL
IISNWRAMASDF
768
11
32
50
6710
|
|
POL
SSMTKILEPF
351
10
33
52
6711
|
|
POL
QSSMTKILEPF
350
11
33
52
6712
|
|
POL
LTEAVQKI
560
8
34
53
6713
|
|
POL
CTIILEGKI
817
8
35
55
6714
|
|
POL
ETKLGKAGY
641
9
35
55
6715
|
|
POL
CTIILEGKII
817
9
35
55
6716
|
|
POL
ATDIQTKEL
957
9
35
55
6717
|
|
POL
ETKLGKAGYV
641
10
35
55
6718
|
|
POL
IATDIQTKEL
956
10
35
55
6719
|
|
POL
ITKIQNFRV
969
9
36
57
6720
|
|
POL
ITKIQNFRVY
969
10
36
57
6721
|
|
POL
ITKIQNFRVYY
969
11
36
57
6722
|
|
POL
PAIFQSSMTKI
346
11
36
56
6723
|
|
POL
QAQPDKSESEL
699
11
36
56
6724
|
|
POL
TAFTIPSI
317
8
37
58
6725
|
|
POL
YTAFTIPSI
316
9
37
58
6726
|
|
POL
LTEEAELEL
484
9
37
58
6727
|
|
POL
LSWVPAIIKGI
725
10
37
58
6728
|
|
POL
GAVVIQDNSDI
999
11
37
58
6729
|
|
POL
QSSMTKIL
350
8
38
59
6730
|
|
POL
KAKIIRDY
1017
8
41
64
6731
|
|
POL
RAMASDFNL
772
9
41
64
6732
|
|
POL
SAGERIIDI
947
9
41
64
6733
|
|
POL
LTQIGCTLNF
177
10
41
64
6734
|
|
POL
YSAGERIIDI
946
10
41
64
6735
|
|
POL
SAGERIIDII
947
10
41
64
6736
|
|
POL
YSAGERIIDII
946
11
41
64
6737
|
|
POL
LTQIGCTL
177
8
42
66
6738
|
|
POL
PAIFQSSM
346
8
42
66
6739
|
|
POL
YSAGERII
946
8
42
66
6740
|
|
POL
ISKIGPENPY
236
10
42
66
6741
|
|
POL
GSPAIFQSSM
344
10
42
66
6742
|
|
POL
WTYQIYQEPF
529
10
42
66
6743
|
|
POL
TTNQKTELQAI
664
11
42
66
6744
|
|
POL
DSWTVNDI
439
8
43
67
6745
|
|
POL
ASCDKCQL
790
8
43
67
6746
|
|
POL
VASCDKCQL
789
9
43
67
6747
|
|
POL
DSWTVNDIQKL
439
11
43
67
6748
|
|
POL
MTKILEPF
353
8
44
69
6749
|
|
POL
QPKELQKQI
961
9
46
72
6750
|
|
POL
ITLWQRPL
90
8
47
73
6751
|
|
POL
ITLWQRPLV
90
9
47
73
6752
|
|
POL
KAIGTVLV
157
8
48
75
6753
|
|
POL
IITNDVKQL
553
8
49
77
6754
|
|
POL
PAGLKKKKSV
286
10
50
78
6755
|
|
POL
QATWIPEWLFV
599
11
51
81
6756
|
|
POL
KSVTVLDV
293
8
51
80
6757
|
|
POL
IITDNGSNF
866
8
51
80
6758
|
|
POL
ATWIPEWEFV
600
10
51
80
6759
|
|
POL
ETVPVKLKPGM
192
11
51
80
6760
|
|
POL
ETPGIRYQYNV
327
11
51
80
6761
|
|
POL
QATWIPEWEF
599
10
52
83
6762
|
|
POL
ETPGIRYQY
327
9
52
81
6763
|
|
POL
ATWIPEWEF
600
9
52
81
6764
|
|
POL
VASGYIEAEV
831
10
52
81
6765
|
|
POL
VASGYIEAEVI
831
11
52
81
6766
|
|
POL
ASGYIEAEV
832
9
53
83
6767
|
|
POL
QSQGVVESM
898
9
53
83
6768
|
|
POL
GTVLVGPTPV
160
10
53
83
6769
|
|
POL
RTQDFWEVQL
272
10
53
83
6770
|
|
POL
VAVIIVASGYI
827
10
53
83
6771
|
|
POL
ASGYIEAEVI
832
10
53
83
6772
|
|
POL
ESMNKELKKI
904
10
53
83
6773
|
|
POL
ISPIETVPVKL
188
11
53
83
6774
|
|
POL
ESMNKELKKII
904
11
53
83
6775
|
|
POL
QATWIPEW
599
8
54
86
6776
|
|
POL
RTQDFWEV
272
8
55
86
6777
|
|
POL
DAYFSVPL
302
8
55
86
6778
|
|
POL
TTNQKTEL
664
8
55
86
6779
|
|
POL
ISPIETYPY
188
9
56
88
6780
|
|
POL
LTEEKIKAL
213
9
56
88
6781
|
|
POL
VTVLDVGDAY
295
10
56
88
6782
|
|
POL
KTAVQMAVFI
925
10
S6
88
6783
|
|
POL
VTVLDVGDAYF
295
11
56
88
6784
|
|
POL
PAETGQETAYF
842
11
56
88
6785
|
|
POL
LAENREIL
492
8
57
89
6786
|
|
POL
NTPPLVKL
610
8
57
89
6787
|
|
POL
CSPGIWQL
808
8
57
89
6788
|
|
POL
KTAVQMAV
925
8
57
89
6789
|
|
POL
NTPPLVKLW
610
9
57
89
6790
|
|
POL
ETGQETAYF
844
9
57
89
6791
|
|
POL
KTAVQMAVF
925
9
57
89
6792
|
|
POL
NTPPLVKLWY
610
10
57
89
6793
|
|
POL
FAIKKKDSTKW
250
11
57
89
6794
|
|
POL
QAEIILKTAVQM
920
11
57
89
6795
|
|
POL
STKWRKLVDI
257
10
58
91
6796
|
|
POL
VTDSQYALGI
688
10
58
91
6797
|
|
POL
PAETGQETAY
842
10
58
91
6798
|
|
POL
DSTKWRKLVDF
256
11
58
91
6799
|
|
POL
VTDSQYALGII
688
11
58
91
6800
|
|
POL
DSTKWRKL
256
8
59
92
6801
|
|
POL
STKWRKLV
257
8
59
92
6802
|
|
POL
VTDSQYAL
688
8
59
92
6803
|
|
POL
DSQYALGI
690
8
59
92
6804
|
|
POL
ETGQETAY
844
8
59
92
6805
|
|
POL
DSTKWRKLV
256
9
59
92
6806
|
|
POL
DSQYALGII
690
9
59
92
6807
|
|
POL
VAVIIVASGY
827
9
59
92
6808
|
|
POL
QAEIILKTAV
920
9
59
92
6809
|
|
POL
TAVQMAVFI
926
9
59
92
6810
|
|
POL
MAVFIIINF
930
8
60
94
6811
|
|
POL
CTLNPPISPI
182
10
60
94
6812
|
|
POL
TAVQMAVP
926
8
61
95
6813
|
|
POL
DTGADDTVL
112
9
61
95
6814
|
|
POL
WTVNDIQKLV
441
10
61
95
6815
|
|
POL
WTVNDIQKL
441
9
62
97
6816
|
|
POL
DTGADDTV
112
8
63
98
6817
|
|
REV
RARQRQIIISI
50
10
10
16
6818
|
|
REV
GTQGVGSPQI
97
10
11
18
6819
|
|
REV
RSAEPVPL
70
8
12
19
6820
|
|
REV
SAEPVPLQL
71
9
12
19
6821
|
|
REV
RSAEPVPLQL
70
10
12
19
6822
|
|
REV
RSGDSDEELL
4
10
16
25
6823
|
|
REV
QARKNRRRRW
40
10
16
25
6824
|
|
REV
RSGDSDEEL
4
9
17
27
6825
|
|
REV
GTSGTQGV
94
8
21
33
6826
|
|
REV
PAEPVPLQL
71
9
21
33
6827
|
|
REV
QARRNRRRRW
40
10
38
59
6828
|
|
TAT
PTGPKESKKKV
88
11
12
19
6829
|
|
VIF
KSLVKYHM
22
8
10
16
6830
|
|
VIF
FSDSAIRKAI
120
10
10
16
6831
|
|
VIF
YSTQIDPDL
99
9
11
17
6832
|
|
VIF
YSTQVDPGL
99
9
11
17
6833
|
|
VIF
STQVDPGL
100
8
11
17
6834
|
|
VIF
KSLVKIIIIMYI
22
10
11
17
6835
|
|
VIF
VSIEWRLRRY
88
10
11
17
6836
|
|
VIF
PSESAIRKAIL
120
11
11
17
6837
|
|
VIF
GSLQYLALKAL
148
11
11
17
6838
|
|
VIF
STQIDPDL
100
8
12
19
6839
|
|
VIF
ESAIRNAI
122
8
12
19
6840
|
|
VIF
SAIRNAIL
123
8
12
19
6841
|
|
VIF
QTGERDWIIL
75
9
12
19
6842
|
|
VIF
ESAIRNAIL
122
9
12
19
6843
|
|
VIF
KTKPPLPSV
164
9
12
19
6844
|
|
VIF
PSESAIRKAI
120
10
12
19
6845
|
|
VIF
PSESAIRNAI
120
10
12
19
6846
|
|
VIF
PSESAIRNAIL
120
11
12
19
6847
|
|
VIF
GSLQYLALAAL
148
11
12
19
6848
|
|
VIF
LADQLIIIMIIY
107
10
13
20
6849
|
|
VIF
ESRIIPKVSSIW
45
11
13
20
6850
|
|
VIF
LADQLIIIMIIYF
107
11
13
20
6851
|
|
VIF
PSVKKLTEDRW
173
11
13
20
6852
|
|
VIF
NSLVKIIIIMYV
22
10
14
22
6853
|
|
VIF
LADQLIIILYY
107
10
14
22
6854
|
|
VIF
RIWKSLVKIIIIM
19
11
14
22
6855
|
|
VIF
LADQLIIILYYF
107
11
14
22
6856
|
|
VIF
LADQLIIILY
107
9
15
23
6857
|
|
VIF
KTKGIIRGSIITM
188
11
15
23
6858
|
|
VIF
ESAIRKAIL
122
9
16
25
6859
|
|
VIF
LADQLIIIM
107
8
17
27
6860
|
|
VIF
ESAIRKAI
122
8
17
27
6861
|
|
VIF
KSLVKIIIIM
22
8
18
28
6862
|
|
VIF
KSLVKIIIIMY
22
9
18
28
6863
|
|
VIF
DSAIRKAIL
122
9
19
30
6864
|
|
VIF
DSAIRKAI
122
8
20
31
6865
|
|
VIF
HTGERDWIIL
75
9
21
33
6866
|
|
VIF
NSLVKHHMY
22
9
24
38
6867
|
|
VIF
RTWNSLVKIIIIM
19
11
24
38
6868
|
|
VIF
LADQLIIIL
107
8
25
39
6869
|
|
VIF
NSLVKIIIIM
22
8
27
42
6870
|
|
VIF
ISSEVIIIPL
51
9
27
42
6871
|
|
VIF
VSSEVHIPL
51
9
27
42
6872
|
|
VIF
GSLQYLALTAL
148
11
31
48
6873
|
|
VIF
SAIRKAIL
123
8
35
55
6874
|
|
VIF
QAGIINKVGSL
141
10
38
59
6875
|
|
VIF
SSEVIIIPL
52
8
55
86
6876
|
|
VIF
GSLQYLAL
148
8
58
91
6877
|
|
VPR
WALELLEEL
18
9
09
15
6878
|
|
VPR
ETYGDTWTGV
48
10
11
17
6879
|
|
VPR
EAVRIIPPRI
29
9
14
22
6880
|
|
VPR
EAVRIIPPRIW
29
10
14
22
6881
|
|
VPR
EAVRIIFPRIWL
29
11
14
22
6882
|
|
VPR
KSEAVRIIP
27
5
15
23
6883
|
|
VPR
WAGVEAIIRI
54
10
15
23
6884
|
|
VPR
WAGVEAIIRIL
54
11
15
23
6885
|
|
VPR
WAGVEAII
54
8
16
25
6886
|
|
VPR
DTWAGVEAI
52
9
16
25
6887
|
|
VPR
ETYGDTWAGV
48
10
16
25
6888
|
|
VPR
NTYGDTWEGV
48
10
16
25
6889
|
|
VPR
DTWAGVEAII
52
10
16
25
6890
|
|
VPR
DTWEGVEAII
52
10
19
30
6891
|
|
VPR
DTWEGVEAI
52
9
20
31
6892
|
|
VPR
EAIIRILQQL
58
10
33
52
6893
|
|
VPR
EAIIRILQQLL
58
11
33
52
6894
|
|
VPR
EAVRIIFPRPW
29
10
34
53
6895
|
|
VPR
EAVRIIFPRPWL
29
11
34
53
6896
|
|
VPR
WTLELLEEL
18
9
42
69
6897
|
|
VPU
LAKYDYRI
5
8
01
25
6898
|
|
VPU
LAKVDYRL
5
8
01
25
6899
|
|
VPU
LAKVDYRIV
5
9
01
25
6900
|
|
VPU
LAKVDYRIVI
5
10
01
25
6901
|
|
VPU
LAKVDYRLGV
5
10
01
25
6902
|
|
VPU
LAKVDYRIVIV
5
11
01
25
6903
|
|
VPU
VTLLSSSKL
94
9
01
50
6904
|
|
VPU
LAIVALVV
13
8
12
20
6905
|
|
VPU
WTIVFIEY
34
8
12
19
6906
|
|
VPU
ESEGDQEEL
73
9
13
20
6907
|
|
VPU
ESEGDTEEL
75
9
13
20
6908
|
|
VPU
IAIVVWTIV
28
9
20
31
6909
|
|
VPU
IAIVVWTI
28
8
23
36
6910
|
|
TABLE XIV
|
|
|
HIV B62 Super Motif Peptides
|
Se-
|
No. of
quence
Conser-
SEQ
|
Pro-
Posi-
Amino
Fre-
vancy
ID
|
tein
Sequence
tion
Acids
quency
(%)
NO.
|
|
ENV
GIGPGQTF
360
8
01
33
6911
|
|
ENV
SIGSGQAF
360
8
01
33
6912
|
|
ENV
KLREIRQF
405
8
01
25
6913
|
|
ENV
EPDRPERI
823
8
01
33
6914
|
|
ENV
PPDRPEGI
823
8
01
33
6915
|
|
ENV
GIGPGQTFY
360
9
01
33
6916
|
|
ENV
SIGSGQAFY
360
9
01
33
6917
|
|
ENV
SIGSGQAFYV
360
10
01
33
6918
|
|
ENV
KQLYATVY
34
8
01
50
6919
|
|
ENV
QLYATVYAGV
34
10
01
50
6920
|
|
ENV
KQLYATVYSGV
34
11
01
50
6921
|
|
ENV
TIGAMFLGF
599
9
03
27
6922
|
|
ENV
MLGAMFLGF
599
9
04
36
6923
|
|
ENV
SLRGLQRGW
889
9
05
18
6924
|
|
ENV
RLGWEGLKYLW
894
11
07
23
6925
|
|
ENV
RLGWEGLKY
894
9
09
29
6926
|
|
ENV
GLRLGWEGLKY
892
11
09
29
6927
|
|
ENV
LILGLVII
21
8
09
15
6928
|
|
ENV
IPRRIRQGF
950
9
10
16
6929
|
|
ENV
ALFYKLDV
202
8
10
16
6930
|
|
ENV
IIMLQLTVW
650
8
10
16
6931
|
|
ENV
DITNWLWY
769
8
10
16
6932
|
|
ENV
DIRQAIICNV
380
9
10
16
6933
|
|
ENV
LPCRIKQIV
485
9
10
16
6934
|
|
ENV
MLQLTVWGI
651
9
10
16
6935
|
|
ENV
DITNWLWYI
769
9
10
16
6936
|
|
ENV
SQELKNSAV
911
9
10
16
6937
|
|
ENV
PIIIYCTPAGF
260
10
10
16
6938
|
|
ENV
TLPCRIKQIV
484
10
10
16
6939
|
|
ENV
IPIIIYCTPAGF
259
11
10
16
6940
|
|
ENV
RVGQAMYAPPI
498
11
10
16
6941
|
|
ENV
WMEWEREIDNY
723
11
10
16
6942
|
|
ENV
ALDKWASLWNW
757
11
10
16
6943
|
|
ENV
SLKGLRLGW
889
9
11
39
6944
|
|
ENV
GIGAVFLGF
598
9
11
18
6945
|
|
ENV
KLWVTVYY
44
8
11
17
6946
|
|
ENV
AVGIGAVF
595
8
11
17
6947
|
|
ENV
KLWVTVYYGV
44
10
11
17
6948
|
|
ENV
AVGIGAVFLGF
595
11
11
17
6949
|
|
ENV
RIGPGQTF
357
8
11
17
6950
|
|
ENV
NITLPCRI
482
8
11
17
6951
|
|
ENV
WQRVGQAM
496
8
11
17
6952
|
|
ENV
QIRCSSNI
512
8
11
17
6953
|
|
ENV
ALFYRLDVV
202
9
11
17
6954
|
|
ENV
GPCTNVSTV
283
9
11
17
6955
|
|
ENV
RIGPGQTFY
357
9
11
17
6956
|
|
ENV
WQRVGQAMY
496
9
11
17
6957
|
|
ENV
GQIRCSSNI
511
9
11
17
6958
|
|
ENV
ALDKWASLW
757
9
11
17
6959
|
|
ENV
AVSLLNATAI
918
10
11
17
6960
|
|
ENV
NITLPCRIKQI
482
11
11
17
6961
|
|
ENV
VVEREKRAVGI
588
11
11
17
6962
|
|
ENV
LLALDKWASLW
755
11
11
17
6963
|
|
ENV
NMWKNDMV
107
8
12
19
6964
|
|
ENV
ALFYRLDV
202
8
12
19
6965
|
|
ENV
RIKQIVNM
488
8
12
19
6966
|
|
ENV
KLICTTTV
687
8
12
19
6967
|
|
ENV
WMEWEREI
723
8
12
19
6968
|
|
ENV
ILKCNDKKF
271
9
12
19
6969
|
|
ENV
RIKQIVNMW
488
9
12
19
6970
|
|
ENV
LICTTTVPW
688
9
12
19
6971
|
|
ENV
GQELKNSAI
911
9
12
19
6972
|
|
ENV
AILIIIPRRI
946
9
12
19
6973
|
|
ENV
AILKCNDKKF
270
10
12
19
6974
|
|
ENV
KLICTTTVPW
687
10
12
19
6975
|
|
ENV
NMTWMEWEREI
720
11
12
19
6976
|
|
ENV
IVGGLIGRII
783
11
12
19
6977
|
|
ENV
ELYKYKVVEI
560
10
13
21
6978
|
|
ENV
DPNPQEVV
91
8
13
20
6979
|
|
ENV
HLLKLTVW
650
8
13
20
6980
|
|
ENV
NVPWNSSW
693
8
13
20
6981
|
|
ENV
EIWDNMTW
716
8
13
20
6982
|
|
ENV
SIRLVNGF
842
8
13
20
6983
|
|
ENV
SIRLYSGF
842
8
13
20
6984
|
|
ENV
RLRDLLLI
867
8
13
20
6985
|
|
ENV
ILIIIPRRI
947
8
13
20
6986
|
|
ENV
EIKNCSFNI
181
9
13
20
6987
|
|
ENV
AITQACPKV
244
9
13
20
6988
|
|
ENV
SLAEEEVVI
311
9
13
20
6989
|
|
ENV
QQHLLKLTV
648
9
13
20
6990
|
|
ENV
LLKLTVWGI
651
9
13
20
6991
|
|
ENV
AQQIILLKLTV
647
10
13
20
6992
|
|
ENV
QQHLLKLTVW
648
10
13
20
6993
|
|
ENV
HLLKLTVWGI
650
10
13
20
6994
|
|
ENV
EQELLELDKW
752
10
13
20
6995
|
|
ENV
VPTDPNPQEVV
88
11
13
20
6996
|
|
ENV
VMHSFNCGGEF
432
11
13
20
6997
|
|
ENV
TITLPCRIKQI
482
11
13
20
6998
|
|
ENV
AQQHLLKLTVW
647
11
13
20
6999
|
|
ENV
SLAEEEVV
311
8
14
22
7000
|
|
ENV
TITLPCRI
482
8
14
22
7001
|
|
ENV
SLLNATAI
920
8
14
22
7002
|
|
ENV
DPEIVMIISF
428
9
14
22
7003
|
|
ENV
GQAMYAPPI
501
9
14
22
7004
|
|
ENV
RIIFAVLSI
791
9
14
22
7005
|
|
ENV
AVAEGTDRV
928
9
14
22
7006
|
|
ENV
EQDLLALDKW
752
10
14
22
7007
|
|
ENV
RIIFAVLSIV
791
10
14
22
7008
|
|
ENV
SLLNATAIAV
920
10
14
22
7009
|
|
ENV
AVAEGTDRVI
928
10
14
22
7010
|
|
ENV
VITQACPKVSF
244
11
14
22
7011
|
|
ENV
GLRIIFAVLSI
789
11
14
22
7012
|
|
ENV
AIAVAEGTDRV
926
11
14
22
7013
|
|
ENV
RLINCNTSAI
236
10
15
24
7014
|
|
ENV
GLIGLRII
786
8
15
23
7015
|
|
ENV
IIFAVLSI
792
8
15
23
7016
|
|
ENV
GPDRPEGI
822
8
15
23
7017
|
|
ENV
LINCNTSAI
237
9
15
23
7018
|
|
ENV
VITQACPKV
244
9
15
23
7019
|
|
ENV
GPCKNVSTV
283
9
15
23
7020
|
|
ENV
DIRQAHCNI
380
9
15
23
7021
|
|
ENV
GLIGLRIIF
786
9
15
23
7022
|
|
ENV
IIFAVLSIV
792
9
15
23
7023
|
|
ENV
LLNATAIAV
921
9
15
23
7024
|
|
ENV
SVITQACPKV
243
10
15
23
7025
|
|
ENV
TLPCRIKQII
484
10
15
23
7026
|
|
ENV
NMWQEVGKAM
494
10
15
23
7027
|
|
ENV
AVAEGTDRII
928
10
15
23
7028
|
|
ENV
NMWQEVGKAMY
494
11
15
23
7029
|
|
ENV
GLIGLRIIFAV
786
11
15
23
7030
|
|
ENV
LIGLRIIF
787
8
16
25
7031
|
|
ENV
VVQREKRAV
588
9
16
25
7032
|
|
ENV
AVAEGTDRI
928
9
16
25
7033
|
|
ENV
RVVQREKRAV
587
10
16
25
7034
|
|
ENV
LIGLRIIFAV
787
10
16
25
7035
|
|
ENV
LVSGFLALAW
845
10
16
25
7036
|
|
ENV
DLRNLCLFSY
856
10
16
25
7037
|
|
ENV
LLNGSLAEEEV
307
11
16
25
7038
|
|
ENV
ELDKWASLWNW
757
11
16
25
7039
|
|
ENV
RLVSGFLALAW
844
11
16
25
7040
|
|
ENV
AIAVAEGTDRI
926
11
16
25
7041
|
|
ENV
VQREKRAV
589
8
17
27
7042
|
|
ENV
IINMWQEV
492
8
17
27
7043
|
|
ENV
KLICTTNV
687
8
17
27
7044
|
|
ENV
SLWNWFDI
763
8
17
27
7045
|
|
ENV
DLRNLCLF
856
8
17
27
7046
|
|
ENV
QIINMWQEV
491
9
17
27
7047
|
|
ENV
LICTTNVPW
688
9
17
27
7048
|
|
ENV
RPNNNTRKSI
347
10
17
27
7049
|
|
ENV
KQIINMWQEV
490
10
17
27
7050
|
|
ENV
EIFRPGGGDM
544
10
17
27
7051
|
|
ENV
KLICTTNVPW
687
10
17
27
7052
|
|
ENV
RIVFAVLSIV
791
10
17
27
7053
|
|
ENV
GVAPTKAKRRV
573
11
17
27
7054
|
|
ENV
WQEVGKAM
496
8
18
28
7055
|
|
ENV
GLRIIFAV
789
8
18
28
7056
|
|
ENV
WQEVGKAMY
496
9
18
28
7057
|
|
ENV
ELDKWASLW
757
9
18
28
7058
|
|
ENV
IVFAVLSIV
792
9
18
28
7059
|
|
ENV
YLRDQQLLGI
672
10
18
28
7060
|
|
ENV
LPCRIKQIINM
485
11
18
28
7061
|
|
ENV
EVGKAMYAPPI
498
11
18
28
7062
|
|
ENV
YLRDQQLLGIW
672
11
18
28
7063
|
|
ENV
LLELDKWASLW
755
11
18
28
7064
|
|
ENV
CLFSYHRLRDF
861
11
18
28
7065
|
|
ENV
KLICTTAV
687
8
19
30
7066
|
|
ENV
LICTTAVPW
688
9
19
30
7067
|
|
ENV
RIVFAVLSI
791
9
19
30
7068
|
|
ENV
KLICTTAVPW
687
10
19
30
7069
|
|
ENV
GLRIVFAVLSI
789
11
19
30
7070
|
|
ENV
ELLELDKW
754
8
20
31
7071
|
|
ENV
IVFAVLSI
792
8
20
31
7072
|
|
ENV
LPCRIKQII
485
9
20
31
7073
|
|
ENV
NMVEQMIIEDI
112
10
20
31
7074
|
|
ENV
NMVEQMIIEDII
112
11
20
31
7075
|
|
ENV
DLLALDKW
754
8
21
33
7076
|
|
ENV
DLEITTIISF
428
9
21
33
7077
|
|
ENV
VPTDPNPQEV
88
10
21
33
7078
|
|
ENV
LIGLRIVFAV
781
10
21
33
7079
|
|
ENV
CVPTDPNPQEV
87
11
21
33
7080
|
|
ENV
GLIGLRIVFAV
786
11
21
33
7081
|
|
ENV
APTKAKRRV
575
9
22
34
7082
|
|
ENV
APTKAKRRVV
575
10
22
34
7083
|
|
ENV
IVELLGRRGW
879
10
22
34
7084
|
|
ENV
PVWKEATTTLF
54
11
22
34
7085
|
|
ENV
EQMIIEDIISLW
115
11
22
34
7086
|
|
ENV
TVQCTIIGIRPV
290
11
22
34
7087
|
|
ENV
RIVELLGRRGW
878
11
22
34
7088
|
|
ENV
ELLGRRGW
881
8
23
37
7089
|
|
ENV
MVEQMIIEDI
113
9
23
36
7090
|
|
ENV
VVKIEPLGV
566
9
23
36
7091
|
|
ENV
MVEQMIIEDII
113
10
23
36
7092
|
|
ENV
KVVKIEPLGV
565
10
23
36
7093
|
|
ENV
EQMHEDII
115
8
24
38
7094
|
|
ENV
VVEREKRAV
588
9
25
39
7095
|
|
ENV
VPTDPNPQEI
88
10
25
39
7096
|
|
ENV
VQCTHGIRPV
292
10
25
39
7097
|
|
ENV
RVVEREKRAV
587
10
25
39
7098
|
|
ENV
QQQNNLLRAI
636
10
25
39
7099
|
|
ENV
CVPTDPNPQEI
87
11
25
39
7100
|
|
ENV
VQCTHGIRPVV
292
11
25
39
7101
|
|
ENV
VQQQNNLLRAI
635
11
25
39
7102
|
|
ENV
TLPCRIKQI
484
9
26
41
7103
|
|
ENV
QQNNLLRAI
637
9
26
41
7104
|
|
ENV
QQSNLLRAI
637
9
26
41
7105
|
|
ENV
QQQSNLLRAI
636
10
26
41
7106
|
|
ENV
IPIHYCAPAGF
259
11
26
41
7107
|
|
ENV
VQQQSNLLRAI
635
11
26
41
7108
|
|
ENV
PIIIYCAPAGF
260
10
27
42
7109
|
|
ENV
YLKDQQLLGI
672
10
27
42
7110
|
|
ENV
YLKDQQLLGIW
672
11
27
42
7111
|
|
ENV
KVSFEPIPIHY
252
11
28
44
7112
|
|
ENV
TVQCTIIGIKPV
290
11
28
44
7113
|
|
ENV
ELYKYKVVKI
560
10
29
46
7114
|
|
ENV
LIGLRIVF
787
8
29
45
7115
|
|
ENV
GLRIVFAV
789
8
29
45
7116
|
|
ENV
GLIGLRIVF
786
9
29
45
7117
|
|
ENV
QMHEDIISLW
116
10
29
45
7118
|
|
ENV
RIKQIINM
488
8
30
47
7119
|
|
ENV
TQACPKVSF
247
9
30
47
7120
|
|
ENV
CPKVSFEPI
250
9
30
47
7121
|
|
ENV
KVSFEPIPI
252
9
30
47
7122
|
|
ENV
RIKQIINMW
488
9
30
47
7123
|
|
ENV
NMWKNNMVEQM
107
11
30
47
7124
|
|
ENV
CPKVSFEPIPI
250
11
30
47
7125
|
|
ENV
IVGGLIGLRIV
783
11
30
47
7126
|
|
ENV
LPCRIKQI
485
8
31
48
7127
|
|
ENV
AVLSIVNRV
795
9
31
48
7128
|
|
ENV
VQCTIIGIKPVV
292
11
31
48
7129
|
|
ENV
KIFIMIVGGLI
778
11
31
48
7130
|
|
ENV
GLIGLRIV
786
8
32
50
7131
|
|
ENV
VQCTIIGIKPV
292
10
32
50
7132
|
|
ENV
LQARVLAV
662
8
33
52
7133
|
|
ENV
RVLAVERY
665
8
33
52
7134
|
|
ENV
QLQARVLAV
661
9
33
52
7135
|
|
ENV
KQLQARVLAV
660
10
33
52
7136
|
|
ENV
LQARVLAVERY
662
11
33
52
7137
|
|
ENV
NLWVTVYYGV
44
10
34
54
7138
|
|
ENV
NVTENFNM
101
8
34
53
7139
|
|
ENV
NMWKNNMV
107
8
34
53
7140
|
|
ENV
HLLQLTVW
650
8
34
53
7141
|
|
ENV
NVTENFNMW
101
9
34
53
7142
|
|
ENV
QQHLLQLTV
648
9
34
53
7143
|
|
ENV
LLQLTVWGI
651
9
34
53
7144
|
|
ENV
AQQHLLQLTV
647
10
34
53
7145
|
|
ENV
QQHLLQLTVW
648
10
34
53
7146
|
|
ENV
IILLQLTVWGI
650
10
34
53
7147
|
|
ENV
AQQHLLQLTVW
647
11
34
53
7148
|
|
ENV
NLWVTVYY
44
8
35
56
7149
|
|
ENV
IMIVGGLI
781
8
35
56
7150
|
|
ENV
FIMIVGGLI
780
9
35
55
7151
|
|
ENV
DLRSLCLFSY
856
10
35
55
7152
|
|
ENV
VQARQLLSGI
625
10
36
56
7153
|
|
ENV
SIVNRVRQGY
798
10
36
56
7154
|
|
ENV
TMGAASITLTV
615
11
36
56
7155
|
|
ENV
TVQARQLLSGI
624
11
36
56
7156
|
|
ENV
VQARQLLSGIV
625
11
36
56
7157
|
|
ENV
MIVGGLIGLRI
782
11
36
56
7158
|
|
ENV
DMRDNWRSELY
552
11
37
58
7159
|
|
ENV
VLSIVNRV
796
8
38
59
7160
|
|
ENV
DLRSLCLF
856
8
38
59
7161
|
|
ENV
IVNRVRQGY
799
9
38
59
7162
|
|
ENV
RPGGGDMRDNW
547
11
38
59
7163
|
|
ENV
YIKIFIMIV
776
9
39
61
7164
|
|
ENV
GIKQLQARV
658
9
40
63
7165
|
|
ENV
TLFCASDAKAY
64
11
40
63
7166
|
|
ENV
IVGGLIGLRI
783
10
42
66
7167
|
|
ENV
YIKIFIMI
776
8
43
67
7168
|
|
ENV
WLWYIKIFIM
773
10
43
67
7169
|
|
ENV
WLWYIKIFIMI
773
11
43
67
7170
|
|
ENV
LQLTVWGI
652
8
44
69
7171
|
|
ENV
SLWDQSLKPCV
123
11
47
75
7172
|
|
ENV
RVRQGYSPLSF
802
11
47
73
7173
|
|
ENV
RQGYSPLSF
804
9
48
75
7174
|
|
ENV
GIWGCSGKLI
680
10
48
75
7175
|
|
ENV
RQLLSGIV
628
8
49
77
7176
|
|
ENV
NVWATIIACV
80
9
49
77
7177
|
|
ENV
WLWYIKIFI
773
9
49
77
7178
|
|
ENV
DQSLKPCV
126
8
50
78
7179
|
|
ENV
WLWYIKIF
773
8
50
78
7180
|
|
ENV
TVQCTIIGI
290
8
51
80
7181
|
|
ENV
DQQLLGIW
675
8
51
80
7182
|
|
ENV
NVSTVQCTIIGI
287
11
51
80
7183
|
|
ENV
KPCVKLTPLCV
130
11
54
84
7184
|
|
ENV
TVYYGVPV
48
8
55
86
7185
|
|
ENV
TVYYGVPVW
48
9
55
86
7186
|
|
ENV
CVKLTPLCV
132
9
55
86
7187
|
|
ENV
FLGAAGSTM
608
9
55
86
7188
|
|
ENV
WVTVYYGVPV
46
10
55
86
7189
|
|
ENV
WVTVYYGVPVW
46
11
55
86
7190
|
|
ENV
ELYKYKVV
560
8
56
89
7191
|
|
ENV
WVTVYYGV
46
8
58
91
7192
|
|
GAG
PPPESFRF
510
8
01
33
7193
|
|
GAG
EPIDKELY
537
8
01
25
7194
|
|
GAG
APPPESFRF
509
9
01
33
7195
|
|
GAG
KQEPIDKELY
535
10
01
25
7196
|
|
GAG
KQETIDKDLY
535
10
01
25
7197
|
|
GAG
EPLTALRSLF
547
10
01
33
7198
|
|
GAG
PPLASLKSLF
547
10
01
33
7199
|
|
GAG
PPLISLKSLF
547
10
01
33
7200
|
|
GAG
EPTAPPAESF
506
10
01
50
7201
|
|
GAG
EPTAPPPESF
506
10
01
50
7202
|
|
GAG
PPAESFRF
510
8
02
67
7203
|
|
GAG
APPAESFRF
509
9
02
67
7204
|
|
GAG
PPLASLKSLF
546
10
04
24
7205
|
|
GAG
YPLASLRSLF
545
10
07
15
7206
|
|
GAG
YPLASLKSLF
545
10
08
17
7207
|
|
GAG
NIMMQRGNF
407
9
10
17
7208
|
|
GAG
TPSQKQEPI
527
9
10
17
7209
|
|
GAG
NPPIPVGDI
277
9
10
16
7210
|
|
GAG
NPPIPVGDIY
277
10
10
16
7211
|
|
GAG
QIGWMTSNPPI
267
11
10
16
7212
|
|
GAG
KLDKWEKI
12
8
10
16
7213
|
|
GAG
GPVAPGQM
242
8
10
16
7214
|
|
GAG
PPIPVGDI
278
8
10
16
7215
|
|
GAG
PPAESFGF
498
8
10
16
7216
|
|
GAG
PPIPVGDIY
278
9
10
16
7217
|
|
GAG
APPAESFGF
497
9
10
16
7218
|
|
GAG
ALSPRTLNAW
167
10
10
16
7219
|
|
GAG
ALSPRTLNAWV
167
11
10
16
7220
|
|
GAG
IPVGDIYKRWI
280
11
10
16
7221
|
|
GAG
VQNANPDCKSI
347
11
10
16
7222
|
|
GAG
PIPVGDIY
279
8
11
17
7223
|
|
GAG
SQEVKNWM
334
8
11
17
7224
|
|
GAG
IMMQKSNF
408
8
11
17
7225
|
|
GAG
PQDLNMMLNI
202
10
11
17
7226
|
|
GAG
IPVGDIYKRW
280
10
11
17
7227
|
|
GAG
EQASQEVKNW
331
10
11
17
7228
|
|
GAG
TPQDLNMMLNI
201
11
11
17
7229
|
|
GAG
PQDLNMMLNIV
202
11
11
17
7230
|
|
GAG
IVGGIIQAAMQM
211
11
11
17
7231
|
|
GAG
TLRAEQATQDV
327
11
11
17
7232
|
|
GAG
EQASQEVKNWM
331
11
11
17
7233
|
|
GAG
WPSSKGRPGNF
474
11
11
17
7234
|
|
GAG
EPIDKELY
533
8
12
19
7235
|
|
GAG
KQEPIDKELY
531
10
12
19
7236
|
|
GAG
TPQDLNMM
201
8
12
19
7237
|
|
GAG
DLNMMLNI
204
8
12
19
7238
|
|
GAG
TLQEQIAW
263
8
12
19
7239
|
|
GAG
TLYCVIIQKI
86
9
12
19
7240
|
|
GAG
DLNMMLNIV
204
9
12
19
7241
|
|
GAG
IVGGHQAAM
211
9
12
19
7242
|
|
GAG
TLQEQIAWM
263
9
12
19
7243
|
|
GAG
PLTSLKSLF
548
9
12
19
7244
|
|
GAG
PLTSLRSLF
548
9
12
19
7245
|
|
GAG
NIVGGHQAAM
210
10
12
19
7246
|
|
GAG
TLRAEQASQEV
327
11
12
19
7247
|
|
GAG
TIMMQRGNF
407
9
13
22
7248
|
|
GAG
SPTSILDI
302
8
13
20
7249
|
|
GAG
RMYSPTSILDI
299
11
13
20
7250
|
|
GAG
LQEQIAWM
264
8
14
22
7251
|
|
GAG
RMYSPTSI
299
8
14
22
7252
|
|
GAG
VQNAQGQMV
156
9
14
22
7253
|
|
GAG
IVQNAQGQMV
155
10
14
22
7254
|
|
GAG
RVHPVHAGPI
235
10
14
22
7255
|
|
GAG
IVRMYSPTSI
297
10
14
22
7256
|
|
GAG
PIVQNAQGQMV
154
11
14
22
7257
|
|
GAG
KIVRMYSPTSI
296
11
14
22
7258
|
|
GAG
WPSNKGRPGNF
474
11
14
22
7259
|
|
GAG
KVSQNYPI
148
8
15
27
7260
|
|
GAG
KVSQNYPIV
148
9
15
27
7261
|
|
GAG
TQDVKNWM
334
8
15
23
7262
|
|
GAG
PPEESFRF
498
8
15
23
7263
|
|
GAG
ELRSLYNTV
76
9
15
23
7264
|
|
GAG
TLYCVIIQRI
86
9
15
23
7265
|
|
GAG
APPEESFRF
497
9
15
23
7266
|
|
GAG
PLASLKSLF
548
9
15
23
7267
|
|
GAG
VLSGGKLDAW
7
10
15
23
7268
|
|
GAG
SLFNTVATLY
79
10
15
23
7269
|
|
GAG
LQGQMVIIQAI
159
10
15
23
7270
|
|
GAG
EQATQDVKNW
331
10
15
23
7271
|
|
GAG
EPTAPPEESF
494
10
15
23
7272
|
|
GAG
SVLSGGKLDAW
6
11
15
23
7273
|
|
GAG
NLQGQMVIIQAI
158
11
15
23
7274
|
|
GAG
EQATQDVKNWM
331
11
15
23
7275
|
|
GAG
WMTSNPPI
270
8
16
25
7276
|
|
GAG
GPAATLEEM
362
9
16
25
7277
|
|
GAG
WMTSNPPIPV
270
10
16
25
7278
|
|
GAG
GPAATLEEMM
362
10
16
25
7279
|
|
GAG
LLETSEGCRQI
52
11
16
25
7280
|
|
GAG
ALGPAATLEEM
360
11
16
25
7281
|
|
GAG
GPIPPGQM
242
8
17
27
7282
|
|
GAG
DIYKRWII
284
8
17
27
7283
|
|
GAG
PVGDIYKRWI
281
10
17
27
7284
|
|
GAG
PVGDIYKRWII
281
11
17
27
7285
|
|
GAG
ALGPGATLEEM
360
11
17
27
7286
|
|
GAG
QIGWMTNNPPI
267
11
18
29
7287
|
|
GAG
KLDAWEKI
12
8
18
28
7288
|
|
GAG
TQEVKNWM
334
8
18
28
7289
|
|
GAG
PVGDIYKRW
281
9
18
28
7290
|
|
GAG
GPGATLEEM
362
9
18
28
7291
|
|
GAG
EQATQEVKNW
331
10
18
28
7292
|
|
GAG
GPGATLEEMM
362
10
18
28
7293
|
|
GAG
EQATQEVKNWM
331
11
18
28
7294
|
|
GAG
GPIAPGQM
242
8
19
30
7295
|
|
GAG
GPSHKARV
379
8
19
30
7296
|
|
GAG
DIKQGPKEPF
308
10
19
30
7297
|
|
GAG
IVWASRELERF
35
11
19
30
7298
|
|
GAG
GVGGPSHKARV
376
11
19
30
7299
|
|
GAG
WMTNNPPI
270
8
20
31
7300
|
|
GAG
WMTNNPPIPV
270
10
20
31
7301
|
|
GAG
EPTAPPAESF
494
10
20
31
7302
|
|
GAG
YPIVQNAQGQM
153
11
20
31
7303
|
|
GAG
VIEEKAFSPEV
179
11
20
31
7304
|
|
GAG
VQNAQGQM
156
8
21
33
7305
|
|
GAG
KQGPKEPF
310
8
21
33
7306
|
|
GAG
IVQNAQGQM
155
9
21
33
7307
|
|
GAG
PIVQNAQGQM
154
10
21
33
7308
|
|
GAG
KQGPKEPFRDY
310
11
21
33
7309
|
|
GAG
SQVSQNYPI
146
9
22
44
7310
|
|
GAG
SQVSQNYPIV
146
10
22
44
7311
|
|
GAG
WMTDTLLV
340
8
22
34
7312
|
|
GAG
SLYNTVATLY
79
10
22
34
7313
|
|
GAG
RLIIPVHAGPI
235
10
22
34
7314
|
|
GAG
WPSHKGRPGNF
474
11
23
36
7315
|
|
GAG
KVIEEKAF
178
8
24
38
7316
|
|
GAG
WVKVIEEKAF
176
10
24
38
7317
|
|
GAG
TLRAEQATQEV
327
11
24
38
7318
|
|
GAG
LVWASRELERF
35
11
25
39
7319
|
|
GAG
MQMLKETI
219
8
26
41
7320
|
|
GAG
AMQMLKETI
218
9
26
41
7321
|
|
GAG
QVSQNYPI
148
8
27
48
7322
|
|
GAG
QVSQNYPIV
148
9
27
48
7323
|
|
GAG
TLQEQIGW
263
8
27
42
7324
|
|
GAG
IMMQRGNF
408
8
27
42
7325
|
|
GAG
TLQEQIGWM
263
9
27
42
7326
|
|
GAG
GQMVIIQAI
161
8
28
44
7327
|
|
GAG
KVVEEKAF
178
8
28
44
7328
|
|
GAG
WVKVVEEKAF
176
10
28
44
7329
|
|
GAG
VVEEKAFSPEV
179
11
28
44
7330
|
|
GAG
EPFRDYVDRFY
315
11
28
44
7331
|
|
GAG
VQNLQGQM
156
8
29
45
7332
|
|
GAG
LQEQIGWM
264
8
29
45
7333
|
|
GAG
IVQNLQGQM
155
9
29
45
7334
|
|
GAG
VQNLQGQMV
156
9
29
45
7335
|
|
GAG
PIVQNLQGQM
154
10
29
45
7336
|
|
GAG
IVQNLQGQMV
155
10
29
45
7337
|
|
GAG
AISPRTLNAW
167
10
29
45
7338
|
|
GAG
YPIVQNLQGQM
153
11
29
45
7339
|
|
GAG
PIVQNLQGQMV
154
11
29
45
7340
|
|
GAG
AISPRTLNAWV
167
11
29
45
7341
|
|
GAG
TLNAWVKVI
172
9
30
47
7342
|
|
GAG
TLNAWVKVV
172
9
31
48
7343
|
|
GAG
MQMLKDTI
219
8
33
52
7344
|
|
GAG
AMQMLKDTI
218
9
33
52
7345
|
|
GAG
VLAEAMSQV
386
9
33
52
7346
|
|
GAG
RVLAEAMSQV
385
10
33
52
7347
|
|
GAG
NPPIPVGEI
277
9
34
54
7348
|
|
GAG
NPPIPVGEIY
277
10
34
54
7349
|
|
GAG
RLRPGGKKKY
20
10
34
53
7350
|
|
GAG
IPVGEIYKRW
280
10
34
53
7351
|
|
GAG
PIPVGEIYKRW
279
11
34
53
7352
|
|
GAG
IPVGEIYKRWI
280
11
34
53
7353
|
|
GAG
RPGGKKKY
22
8
35
55
7354
|
|
GAG
PPIPVGEI
278
8
35
55
7355
|
|
GAG
PIPVGEIY
279
8
35
55
7356
|
|
GAG
PPIPVGEIY
278
9
35
55
7357
|
|
GAG
EPFRDYVDRFF
315
11
35
55
7358
|
|
GAG
GPGHKARV
379
8
36
56
7359
|
|
GAG
GVGGPGIIKARV
376
11
36
56
7360
|
|
GAG
WMTETLLV
340
8
37
58
7361
|
|
GAG
HPVHAGPI
237
8
38
59
7362
|
|
GAG
RMYSPVSILDI
299
11
38
59
7363
|
|
GAG
EIYKRWII
284
8
39
61
7364
|
|
GAG
PVGEIYKRWII
281
11
39
61
7365
|
|
GAG
KIVRMYSPVSI
296
11
39
61
7366
|
|
GAG
RMYSPVSI
299
8
40
63
7367
|
|
GAG
SPYSILDI
302
8
40
63
7368
|
|
GAG
PVGEIYKRW
281
9
40
63
7369
|
|
GAG
PVGEIYKRWI
281
10
40
63
7370
|
|
GAG
IVRMYSPVSI
297
10
40
63
7371
|
|
GAG
TVATLYCV
83
8
41
64
7372
|
|
GAG
KIVRMYSPV
296
9
41
64
7373
|
|
GAG
DIRQGPKEPF
308
10
41
64
7374
|
|
GAG
PQDLNTMLNTV
202
11
41
64
7375
|
|
GAG
TPQDLNTM
201
8
42
66
7376
|
|
GAG
IVRMYSPV
297
8
42
66
7377
|
|
GAG
RQGPKEPF
310
8
42
66
7378
|
|
GAG
DLNTMLNTV
204
9
42
66
7379
|
|
GAG
RQGPKEPFRDY
310
11
42
66
7380
|
|
GAG
QMREPRGSDI
248
10
44
69
7381
|
|
GAG
GQMREPRGSDI
247
11
44
69
7382
|
|
GAG
VQNANPDCKTI
347
11
45
70
7383
|
|
GAG
TVGGHQAAM
211
9
47
73
7384
|
|
GAG
TVGGHQAAMQM
211
11
47
73
7385
|
|
GAG
TINEEAAEW
225
9
53
83
7386
|
|
GAG
SPEVIPMF
186
8
55
86
7387
|
|
GAG
APRKKGCW
440
8
55
86
7388
|
|
GAG
SPRTLNAWVKV
169
11
55
86
7389
|
|
GAG
RQANFLGKI
465
9
56
88
7390
|
|
GAG
RQANFLGKIW
465
10
56
88
7391
|
|
GAG
IILGLNKIVRM
290
11
56
88
7392
|
|
GAG
SPRTLNAW
169
8
57
89
7393
|
|
GAG
IILGLNKI
290
8
57
89
7394
|
|
GAG
SPRTLNAWV
169
9
57
89
7395
|
|
GAG
WIILGLNKI
289
9
57
89
7396
|
|
GAG
IILGLNKIV
290
9
57
89
7397
|
|
GAG
WIILGLNKIV
289
10
57
89
7398
|
|
GAG
ILGLNKIVRM
291
10
57
89
7399
|
|
GAG
ILGLNKIVRMY
291
11
57
89
7400
|
|
GAG
ILGLNKIV
291
8
58
91
7401
|
|
GAG
EMMTACQGV
369
9
59
92
7402
|
|
GAG
GLNKIVRM
293
8
60
94
7403
|
|
GAG
MMTACQGV
370
8
60
94
7404
|
|
GAG
GLNKIVRMY
293
9
60
94
7405
|
|
GAG
TLNAWVKV
172
8
61
95
7406
|
|
GAG
GPKEPFRDY
312
9
63
98
7407
|
|
GAG
GPKEPFRDYV
312
10
63
98
7408
|
|
GAG
EPFRDYVDRF
315
10
63
98
7409
|
|
NEF
APTAAKGV
34
8
01
33
7410
|
|
NEF
APTAAKGVGAV
34
11
01
33
7411
|
|
NEF
KQAEPAAEGV
32
10
01
17
7412
|
|
NEF
RQAPTAAKGV
32
10
01
17
7413
|
|
NEF
AQAEPAAAGV
33
10
01
17
7414
|
|
NEF
EPAADGVGAV
40
10
04
15
7415
|
|
NEF
VPLRPMTF
101
8
10
16
7416
|
|
NEF
IIPICQIIGM
259
8
10
16
7417
|
|
NEF
QVPLRPMTF
100
9
10
16
7418
|
|
NEF
PQVPLRPMTF
99
10
10
16
7419
|
|
NEF
LLIIPICQHGM
257
10
10
16
7420
|
|
NEF
IIMARELHPEY
320
10
10
16
7421
|
|
NEF
RPQVPLRPMTF
98
11
10
16
7422
|
|
NEF
CLLHPMSQIIGM
256
11
10
16
7423
|
|
NEF
IIMARELIIPEYY
320
11
10
16
7424
|
|
NEF
WQNYTPGPGV
204
10
11
17
7425
|
|
NEF
VPVDPREV
230
8
11
17
7426
|
|
NEF
LVPVDPREV
229
9
11
17
7427
|
|
NEF
KLVPVDPREV
228
10
11
17
7428
|
|
NEF
PMTYKGAF
105
8
12
19
7429
|
|
NEF
HPMSQIIGM
259
8
12
19
7430
|
|
NEF
RPMTYKGAF
104
9
12
19
7431
|
|
NEF
LLIIPMSQIIGM
257
10
12
19
7432
|
|
NEF
PLRPMTYKGAF
102
11
12
19
7433
|
|
NEF
SQKRQDILDLW
177
11
12
19
7434
|
|
NEF
WVYHTQGF
191
8
13
20
7435
|
|
NEF
TPGPGTRF
208
8
13
20
7436
|
|
NEF
GIRYPLTF
213
8
13
20
7437
|
|
NEF
WVYHTQGFF
191
9
13
20
7438
|
|
NEF
DLWVYIITQGF
188
10
13
20
7439
|
|
NEF
GPGIRYPLTF
210
10
13
20
7440
|
|
NEF
GPGTRFPLTF
210
10
13
20
7441
|
|
NEF
GIRYPLTFGW
213
10
13
20
7442
|
|
NEF
DLWVYHTQGFF
188
11
13
20
7443
|
|
NEF
DLEKHGAI
57
8
14
22
7444
|
|
NEF
WLEAQEEEEV
79
10
15
24
7445
|
|
NEF
AQEEEEVGF
83
9
17
27
7446
|
|
NEF
AQEEEEVGFPV
83
11
17
27
7447
|
|
NEF
TPGPGIRY
208
8
17
27
7448
|
|
NEF
FPLTFGWCF
217
9
17
27
7449
|
|
NEF
TQGFFPDWQNY
195
11
17
27
7450
|
|
NEF
WQNYTPGPGI
204
10
18
29
7451
|
|
NEF
LIYSKKRQEI
174
10
18
28
7452
|
|
NEF
GLIYSKKRQEI
173
11
18
28
7453
|
|
NEF
DILDLWVY
185
8
20
31
7454
|
|
NEF
RQDILDLWV
182
9
20
31
7455
|
|
NEF
RQDILDLWVY
182
10
20
31
7456
|
|
NEF
WVYHTQGY
191
8
21
33
7457
|
|
NEF
WVYHTQGYF
191
9
21
33
7458
|
|
NEF
DLWVYIITQGY
188
10
21
33
7459
|
|
NEF
DLWVYHTQGYF
188
11
21
33
7460
|
|
NEF
TQGFFPDW
195
8
22
34
7461
|
|
NEF
YPLTFGWCF
217
9
24
38
7462
|
|
NEF
RQDILDLW
182
8
25
39
7463
|
|
NEF
RQEILDLWVY
182
10
32
50
7464
|
|
NEF
EILDLWVY
185
8
33
52
7465
|
|
NEF
RQEILDLWV
182
9
35
55
7466
|
|
NEF
PLTFGWCFKLV
219
11
35
55
7467
|
|
NEF
RPQVPLRPMTY
98
11
36
56
7468
|
|
NEF
TQGYFPDWQNY
195
11
36
56
7469
|
|
NEF
RQEILDLW
182
8
37
58
7470
|
|
NEF
TQGYFPDW
195
8
37
58
7471
|
|
NEF
EVGFPVRPQV
91
10
40
63
7472
|
|
NEF
PLTFGWCF
219
8
43
67
7473
|
|
NEF
PQVPLRPMTY
99
10
45
70
7474
|
|
NEF
VPLRPMTY
101
8
46
73
7475
|
|
NEF
QVPLRPMTY
100
9
46
72
7476
|
|
NEF
RPQVPLRPM
98
9
47
73
7477
|
|
NEF
PVRPQVPLRPM
95
11
47
73
7478
|
|
NEF
PQVPLRPM
99
8
56
88
7479
|
|
POL
SPTSRELQV
35
9
01
33
7480
|
|
POL
AISLSLPQI
80
9
01
33
7481
|
|
POL
SPSSRELQV
38
9
01
50
7482
|
|
POL
GPERALSV
70
8
01
20
7483
|
|
POL
VPTFNFPQI
79
9
01
17
7484
|
|
POL
EPGEDRELSV
69
10
01
17
7485
|
|
POL
GQRQGTVSLSF
69
11
01
17
7486
|
|
POL
PQGEAREF
9
8
10
16
7487
|
|
POL
FPQGEAREF
8
9
10
16
7488
|
|
POL
LIEICGHKAI
150
10
10
16
7489
|
|
POL
AVQKIATESI
563
10
10
16
7490
|
|
POL
MLTQLGCTLNF
176
11
10
16
7491
|
|
POL
AVQKIATESIV
563
11
10
16
7492
|
|
POL
AVKAACWWAGI
877
11
10
16
7493
|
|
POL
IQTKELQKQII
960
11
10
16
7494
|
|
POL
RIGPENPY
238
8
11
17
7495
|
|
POL
YQLETEPI
619
8
11
17
7496
|
|
POL
AQEDHEKY
760
8
11
17
7497
|
|
POL
GIQQEFGI
886
8
11
17
7498
|
|
POL
KVVPRRKV
1011
8
11
17
7499
|
|
POL
VPRRKVKI
1013
8
11
17
7500
|
|
POL
VVPRRKVKI
1012
9
11
17
7501
|
|
POL
VPRRKVKII
1013
9
11
17
7502
|
|
POL
IIKDYGKQM
1020
9
11
17
7503
|
|
POL
GIQQEFGIPY
886
10
11
17
7504
|
|
POL
KVVPRRKVKI
1011
10
11
17
7505
|
|
POL
VVPRRKVKII
1012
10
11
17
7506
|
|
POL
KIIKDYGKQM
1019
10
11
17
7507
|
|
POL
KISRIGPENPY
235
11
11
17
7508
|
|
POL
IPSTNNETPGI
321
11
11
17
7509
|
|
POL
KLWYQLETEPI
616
11
11
17
7510
|
|
POL
KVVPRRKVKII
1011
11
11
17
7511
|
|
POL
KQIIKIQNF
967
9
12
19
7512
|
|
POL
IIKIQNFRV
969
9
12
19
7513
|
|
POL
IIKIQNFRVY
969
10
12
19
7514
|
|
POL
KQIIKIQNFRV
967
11
12
19
7515
|
|
POL
IIKIQNFRVYY
969
11
12
19
7516
|
|
POL
RPLVTVKI
95
8
12
19
7517
|
|
POL
EINLPGKW
122
8
12
19
7518
|
|
POL
QIIKIQNF
968
8
12
19
7519
|
|
POL
VIQDNSEI
1003
8
12
19
7520
|
|
POL
RQIILLRWGF
395
9
12
19
7521
|
|
POL
NQKTELIIAI
666
9
12
19
7522
|
|
POL
IIDIIASDI
952
9
12
19
7523
|
|
POL
IVDIIATDI
952
9
12
19
7524
|
|
POL
VVIQDNSEI
1002
9
12
19
7525
|
|
POL
IQDNSEIKV
1004
9
12
19
7526
|
|
POL
WQRPLVTVKI
93
10
12
19
7527
|
|
POL
RQYDQIPIEI
144
10
12
19
7528
|
|
POL
GQDQWTYQIY
525
10
12
19
7529
|
|
POL
RMRGAIITNDV
548
10
12
19
7530
|
|
POL
NQKTELQAIY
666
10
12
19
7531
|
|
POL
RIIDIIASDI
951
10
12
19
7532
|
|
POL
RIVDIIATDI
951
10
12
19
7533
|
|
POL
QIIKIQNFRV
968
10
12
19
7534
|
|
POL
AVVIQDNSEI
1000
10
12
19
7535
|
|
POL
VIQDNSEIKV
1003
10
12
19
7536
|
|
POL
IQDNSEIKVV
1004
10
12
19
7537
|
|
POL
VLEEINLPGKW
119
11
12
19
7538
|
|
POL
ELRQHLLRWGF
393
11
12
19
7539
|
|
POL
IIPDKWTVQPIV
424
11
12
19
7540
|
|
POL
IQKQGQDQWTY
521
11
12
19
7541
|
|
POL
LQKQIIKIQNF
965
11
12
19
7542
|
|
POL
QIIKIQNFRVY
968
11
12
19
7543
|
|
POL
VVIQDNSEIKV
1002
11
12
19
7544
|
|
POL
VIQDNSEIKVV
1003
11
12
19
7545
|
|
POL
ELQKQIIKI
964
9
13
21
7546
|
|
POL
NLKTGKYARM
540
10
13
21
7547
|
|
POL
DINLPGKW
122
8
13
20
7548
|
|
POL
RQYDQIPI
144
8
13
20
7549
|
|
POL
QLPEKDSW
434
8
13
20
7550
|
|
POL
VLPEKDSW
434
8
13
20
7551
|
|
POL
LQKQIIKI
965
8
13
20
7552
|
|
POL
IQLPEKDSW
433
9
13
20
7553
|
|
POL
IVLPEKDSW
433
9
13
20
7554
|
|
POL
IQKQGQDQW
521
9
13
20
7555
|
|
POL
GQDQWTYQI
525
9
13
20
7556
|
|
POL
SPTRRELQVW
29
10
13
20
7557
|
|
POL
KVRQYDQIPI
142
10
13
20
7558
|
|
POL
LIEICGKKAI
150
10
13
20
7559
|
|
POL
PIQLPEKDSW
432
10
13
20
7560
|
|
POL
PIVLPEKDSW
432
10
13
20
7561
|
|
POL
QLPEKDSWTV
434
10
13
20
7562
|
|
POL
VLPEKDSWTV
434
10
13
20
7563
|
|
POL
EIQKQGQDQW
520
10
13
20
7564
|
|
POL
EQAEIILKTAV
919
10
13
20
7565
|
|
POL
VLEDINLPGKW
119
11
13
20
7566
|
|
POL
ILIEICGKKAI
149
11
13
20
7567
|
|
POL
QPIQLPEKDSW
431
11
13
20
7568
|
|
POL
QPIVLPEKDSW
431
11
13
20
7569
|
|
POL
IQLPEKDSWTV
433
11
13
20
7570
|
|
POL
IVLPEKDSWTV
433
11
13
20
7571
|
|
POL
KQGQDQWTYQI
523
11
13
20
7572
|
|
POL
LIKKEKVYLSW
717
11
13
20
7573
|
|
POL
KLAGRWPVKTI
855
11
13
20
7574
|
|
POL
RPLVTIKI
95
8
14
22
7575
|
|
POL
KQNPDIVI
362
8
14
22
7576
|
|
POL
KIATESIV
566
8
14
22
7577
|
|
POL
YQLEKDPI
619
8
14
22
7578
|
|
POL
SPTRRELQV
29
9
14
22
7579
|
|
POL
KQNPDIVIY
362
9
14
22
7580
|
|
POL
VQKIATESI
564
9
14
22
7581
|
|
POL
KIATESIVI
566
9
14
22
7582
|
|
POL
WQRPLVTIKI
93
10
14
22
7583
|
|
POL
VQKIATESIV
564
10
14
22
7584
|
|
POL
KIATESIVIW
566
10
14
22
7585
|
|
POL
TIHTDNGSNF
864
10
14
22
7586
|
|
POL
EPFRKQNPDIV
358
11
14
22
7587
|
|
POL
KQNPDIVIYQY
362
11
14
22
7588
|
|
POL
ELREHLLKWGF
393
11
14
22
7589
|
|
POL
VQKIATESIVI
564
11
14
22
7590
|
|
POL
KLWYQLEKDPI
616
11
14
22
7591
|
|
POL
LVEICTEM
221
8
15
24
7592
|
|
POL
KIKALVEI
217
8
15
23
7593
|
|
POL
TQLGCTLNF
178
9
15
23
7594
|
|
POL
ALVEICTEM
220
9
15
23
7595
|
|
POL
ELRQHLLRW
393
9
15
23
7596
|
|
POL
IQKQGQGQW
521
9
15
23
7597
|
|
POL
KQGQDQWTY
523
9
15
23
7598
|
|
POL
IQKETWEAW
585
9
15
23
7599
|
|
POL
LVSAGIRKV
743
9
15
23
7600
|
|
POL
LPGRWKPKMI
125
10
15
23
7601
|
|
POL
EIQKQGQGQW
520
10
15
23
7602
|
|
POL
PIQKETWEAW
584
10
15
23
7603
|
|
POL
IQKETWEAWW
585
10
15
23
7604
|
|
POL
QVDKLVSAGI
739
10
15
23
7605
|
|
POL
KLVSAGIRKV
742
10
15
23
7606
|
|
POL
TQLGCTLNFPI
178
11
15
23
7607
|
|
POL
PLTEEKIKALV
212
11
15
23
7608
|
|
POL
IQKQGQGQWTY
521
11
15
23
7609
|
|
POL
LPIQKETWEAW
583
11
15
23
7610
|
|
POL
PIQKETWEAWW
584
11
15
23
7611
|
|
POL
HLALQDSGLEV
675
11
15
23
7612
|
|
POL
EQVDKLVSAGI
738
11
15
23
7613
|
|
POL
LVSAGIRKVLF
743
11
15
23
7614
|
|
POL
QLGCTLNF
179
8
16
25
7615
|
|
POL
QLEKEPIV
620
8
16
25
7616
|
|
POL
AQEEHERY
760
8
16
25
7617
|
|
POL
LPGRWKPKM
125
9
16
25
7618
|
|
POL
YQLEKEPIV
619
9
16
25
7619
|
|
POL
IQQEFGIPY
887
9
16
25
7620
|
|
POL
QLGCTLNFPI
179
10
16
25
7621
|
|
POL
EPFRKQNPDI
358
10
16
25
7622
|
|
POL
TPKFKLPI
578
8
17
27
7623
|
|
POL
NPDIVIYQY
364
9
17
27
7624
|
|
POL
ELREIILLKW
393
9
17
27
7625
|
|
POL
NPDIVIYQYM
364
10
17
27
7626
|
|
POL
MLTQIGCTLNF
176
11
17
27
7627
|
|
POL
NLKTGKYAKM
540
10
18
29
7628
|
|
POL
SVPLDKDF
306
8
18
28
7629
|
|
POL
DIVIYQYM
366
8
18
28
7630
|
|
POL
TLWQRPLVTV
91
10
18
28
7631
|
|
POL
IIGRNMLTQI
171
10
18
28
7632
|
|
POL
VPLDKDFRKY
307
10
18
28
7633
|
|
POL
NIIGRNMLTQI
170
11
18
28
7634
|
|
POL
SVPLDKDFRKY
306
11
18
28
7635
|
|
POL
LLRGTKALTEV
471
11
18
28
7636
|
|
POL
ELVNQIIEQLI
708
11
18
28
7637
|
|
POL
AMASDFNLPPI
773
11
18
28
7638
|
|
POL
PLWKGPAKLLW
985
11
18
28
7639
|
|
POL
PLDKDFRKY
308
9
19
30
7640
|
|
POL
WQRPLVTV
93
8
19
30
7641
|
|
POL
EICGHKAI
152
8
19
30
7642
|
|
POL
LVNQIIEQLI
709
10
19
30
7643
|
|
POL
LVSQIIEQLI
709
10
19
30
7644
|
|
POL
EICGIIKAIGTV
152
11
19
30
7645
|
|
POL
ELVSQIIEQLI
708
11
19
30
7646
|
|
POL
QQEFGIPY
888
8
20
32
7647
|
|
POL
RQYDQILI
144
8
20
31
7648
|
|
POL
SQIIEQLI
711
8
20
31
7649
|
|
POL
KLPIQKETW
582
9
20
31
7650
|
|
POL
KVRQYDQILI
142
10
20
31
7651
|
|
POL
RQYDQILIEI
144
10
20
31
7652
|
|
POL
DLEIGQHRTKI
381
11
20
31
7653
|
|
POL
LIKKEKVYLAW
717
11
20
31
7654
|
|
POL
TVKAACWWAGI
877
11
20
31
7655
|
|
POL
KVIHTDNGSNF
863
11
21
33
7656
|
|
POL
WQRPLVTI
93
8
21
33
7657
|
|
POL
EIGQHRTKI
383
9
21
33
7658
|
|
POL
EPIVGAETF
624
9
21
33
7659
|
|
POL
TLWQRPLVTI
91
10
21
33
7660
|
|
POL
IIGRNLLTQI
171
10
21
33
7661
|
|
POL
EPIVGAETFY
624
10
21
33
7662
|
|
POL
NIIGRNLLTQI
170
11
21
33
7663
|
|
POL
LLTQIGCTLNF
176
11
21
33
7664
|
|
POL
EPIVGAETFYV
624
11
21
33
7665
|
|
POL
DQWTYQIY
527
8
22
34
7666
|
|
POL
GIKQEFGI
886
8
22
34
7667
|
|
POL
GIKQEFGIPY
886
10
22
34
7668
|
|
POL
LLRGAKALTDI
471
11
22
34
7669
|
|
POL
YLAWVPAIIKGI
724
11
22
34
7670
|
|
POL
KLAGRWPVKVI
855
11
22
34
7671
|
|
POL
NPEIVIYQY
364
9
23
36
7672
|
|
POL
IILEGKVILV
819
9
23
36
7673
|
|
POL
KVILVAVIIV
823
9
23
36
7674
|
|
POL
NPEIVIYQYM
364
10
23
36
7675
|
|
POL
EICGKKAIGTV
152
11
23
36
7676
|
|
POL
IILEGKVILVAV
819
11
23
36
7677
|
|
POL
EICGKKAI
152
8
24
38
7678
|
|
POL
NPYNTPIF
243
8
24
38
7679
|
|
POL
EIVIYQYM
366
8
24
38
7680
|
|
POL
NQIIEQLI
711
8
24
38
7681
|
|
POL
VILVAVIIV
824
8
24
38
7682
|
|
POL
TVKAACWW
877
8
24
38
7683
|
|
POL
PVNIIGRNM
168
9
24
38
7684
|
|
POL
TPVNIIGRNM
167
10
24
38
7685
|
|
POL
GPENPYNTPI
240
10
24
38
7686
|
|
POL
NPYNTPIFAI
243
10
24
38
7687
|
|
POL
GQGQWTYQIY
525
10
24
38
7688
|
|
POL
VIHTDNGSNF
864
10
24
38
7689
|
|
POL
GPENPYNTPIF
240
11
24
38
7690
|
|
POL
LQDSGSEV
678
8
25
39
7691
|
|
POL
LLKLAGRW
853
8
25
39
7692
|
|
POL
KQGQGQWTY
523
9
25
39
7693
|
|
POL
GQGQWTYQI
525
9
25
39
7694
|
|
POL
ALQDSGSEV
677
9
25
39
7695
|
|
POL
FLLKLAGRW
852
9
25
39
7696
|
|
POL
LQDSGSEVNI
678
10
25
39
7697
|
|
POL
LLKLAGRWPV
853
10
25
39
7698
|
|
POL
KQGQGQWTYQI
523
11
25
39
7699
|
|
POL
ALQDSGSEVNI
677
11
25
39
7700
|
|
POL
LQDSGSEVNIV
678
11
25
39
7701
|
|
POL
AMASDFNLPPV
773
11
25
39
7702
|
|
POL
FLLKLAGRWPV
852
11
25
39
7703
|
|
POL
QLDCTHLEGKV
814
11
26
41
7704
|
|
POL
PIVAKEIV
782
8
26
41
7705
|
|
POL
EIGQHRAKI
383
9
26
41
7706
|
|
POL
RLPIQKETW
582
9
26
41
7707
|
|
POL
LVSSGIRKV
743
9
26
41
7708
|
|
POL
PPIVAKEIV
781
9
26
41
7709
|
|
POL
DPSKDLIAEI
512
10
26
41
7710
|
|
POL
KLVSSGIRKV
742
10
26
41
7711
|
|
POL
NLPPIVAKEI
779
10
26
41
7712
|
|
POL
LPPIVAKEIV
780
10
26
41
7713
|
|
POL
DLEIGQHRAKI
381
11
26
41
7714
|
|
POL
LVSSGIRKVLF
743
11
26
41
7715
|
|
POL
NLPPIVAKEIV
779
11
26
41
7716
|
|
POL
QIYAGIKV
458
8
27
43
7717
|
|
POL
QIYPGIKV
458
8
27
43
7718
|
|
POL
LQDSGLEV
678
8
27
42
7719
|
|
POL
AQEEHEKY
760
8
27
42
7720
|
|
POL
PPIVAKEI
781
8
27
42
7721
|
|
POL
SQIYAGIKV
457
9
27
42
7722
|
|
POL
SQIYPGIKV
457
9
27
42
7723
|
|
POL
IQKETWETW
585
9
27
42
7724
|
|
POL
ALQDSGLEV
677
9
27
42
7725
|
|
POL
LPPIVAKEI
780
9
27
42
7726
|
|
POL
PIQKETWETW
584
10
27
42
7727
|
|
POL
IQKETWETWW
585
10
27
42
7728
|
|
POL
LQDSGLEVNI
678
10
27
42
7729
|
|
POL
NLPPVVAKEI
779
10
27
42
7730
|
|
POL
LPPVVAKEIV
780
10
27
42
7731
|
|
POL
LPIQKETWETW
583
11
27
42
7732
|
|
POL
PIQKETWETWW
584
11
27
42
7733
|
|
POL
YVTDRGRQKVV
649
11
27
42
7734
|
|
POL
ALQDSGLEVNI
677
11
27
42
7735
|
|
POL
LQDSGLEVNIV
678
11
27
42
7736
|
|
POL
NLPPVVAKEIV
779
11
27
42
7737
|
|
POL
KQEFGIPY
888
8
28
44
7738
|
|
POL
KIKALTEI
217
8
28
44
7739
|
|
POL
PIVGAETF
625
8
28
44
7740
|
|
POL
IVGAETFY
626
8
28
44
7741
|
|
POL
QLIKKEKV
716
8
28
44
7742
|
|
POL
PVVAKEIV
782
8
28
44
7743
|
|
POL
PIVGAETFY
625
9
28
44
7744
|
|
POL
IVGAETFYV
626
9
28
44
7745
|
|
POL
EQLIKKEKV
715
9
28
44
7746
|
|
POL
QLIKKEKVY
716
9
28
44
7747
|
|
POL
LPPVVAKEI
780
9
28
44
7748
|
|
POL
PPVVAKEIV
781
9
28
44
7749
|
|
POL
PIVGAETFYV
625
10
28
44
7750
|
|
POL
EQLIKKEKVY
715
10
28
44
7751
|
|
POL
IIEQLIKKEKV
713
11
28
44
7752
|
|
POL
PPVVAKEI
781
8
29
45
7753
|
|
POL
IIDIIATDI
952
9
29
45
7754
|
|
POL
YVTDRGRQKV
649
10
29
45
7755
|
|
POL
QVDKLVSSGI
739
10
29
45
7756
|
|
POL
RIIDIIATDI
951
10
29
45
7757
|
|
POL
EQVDKLVSSGI
738
11
29
45
7758
|
|
POL
TPKFRLPI
578
8
30
47
7759
|
|
POL
IILVAVIIV
824
8
30
47
7760
|
|
POL
KIILVAVIIV
823
9
30
47
7761
|
|
POL
KLAGRWPVKV
855
10
30
47
7762
|
|
POL
GQWTYQIY
527
8
31
48
7763
|
|
POL
YQLEKEPI
619
8
31
48
7764
|
|
POL
GQETAYFI
846
8
31
48
7765
|
|
POL
HLEGKIILV
819
9
31
48
7766
|
|
POL
IPSINNETPGI
321
11
31
48
7767
|
|
POL
GVYYDPSKDLI
508
11
31
48
7768
|
|
POL
KLWYQLEKEPI
616
11
31
48
7769
|
|
POL
HLEGKIILVAV
819
11
31
48
7770
|
|
POL
KQLTEAVQKI
558
10
32
51
7771
|
|
POL
AVKAACWW
877
8
32
50
7772
|
|
POL
SINNETPGI
323
9
32
50
7773
|
|
POL
FILKLAGRW
852
9
32
50
7774
|
|
POL
EMEKEGKISKI
229
11
32
50
7775
|
|
POL
SINNETPGIRY
323
11
32
50
7776
|
|
POL
FILKLAGRWPV
852
11
32
50
7777
|
|
POL
QLDCTIILEGKI
814
11
33
52
7778
|
|
POL
DVKQLTEAV
556
9
33
52
7779
|
|
POL
ELQKQITKI
964
9
34
54
7780
|
|
POL
KQITKIQNF
967
9
34
54
7781
|
|
POL
KQITKIQNFRV
967
11
34
54
7782
|
|
POL
ILKLAGRW
853
8
34
53
7783
|
|
POL
QLTEAVQKI
559
9
34
53
7784
|
|
POL
ILKLAGRWPV
853
10
34
53
7785
|
|
POL
LQKQITKIQNF
965
11
34
53
7786
|
|
POL
RVYYRDSRDPI
976
11
34
53
7787
|
|
POL
LIKKEKVY
717
8
35
55
7788
|
|
POL
QITKIQNF
968
8
35
55
7789
|
|
POL
NLPGKWKPKM
124
10
35
55
7790
|
|
POL
QITKIQNFRV
968
10
35
55
7791
|
|
POL
NLPGKWKPKMI
124
11
35
55
7792
|
|
POL
QITKIQNFRVY
968
11
35
55
7793
|
|
POL
PIWKGPAKLLW
985
11
35
55
7794
|
|
POL
KLGKAGYV
643
8
36
56
7795
|
|
POL
LQKQITKI
965
8
36
56
7796
|
|
POL
AIFQSSMTKI
347
10
36
56
7797
|
|
POL
AQPDKSESELV
700
11
36
56
7798
|
|
POL
VIQDNSDI
1003
8
37
58
7799
|
|
POL
VVIQDNSDI
1002
9
37
58
7800
|
|
POL
NPYNTPVFAI
243
10
37
58
7801
|
|
POL
QPDKSESELV
701
10
37
58
7802
|
|
POL
AVVIQDNSDI
1000
10
37
58
7803
|
|
POL
VIQDNSDIKV
1003
10
37
38
7804
|
|
POL
YLSWVPAHKGI
724
11
37
58
7805
|
|
POL
VVIQDNSDIKV
1002
11
37
58
7806
|
|
POL
VIQDNSDIKVV
1003
11
37
58
7807
|
|
POL
NPYNTPVF
243
8
38
59
7808
|
|
POL
FQSSMTKI
349
8
38
59
7809
|
|
POL
IQDNSDIKV
1004
9
38
59
7810
|
|
POL
GPENPYNTPV
240
10
38
59
7811
|
|
POL
IQDNSDIKVV
1004
10
38
59
7812
|
|
POL
GPENPYNTPVF
240
11
38
59
7813
|
|
POL
ILKEPVHGVYY
498
11
38
59
7814
|
|
POL
LPGKWKPKM
125
9
39
61
7815
|
|
POL
LPGKWKPKMI
125
10
39
61
7816
|
|
POL
LPEKDSWTV
435
9
40
63
7817
|
|
POL
ILKEPVHGVY
498
10
40
63
7818
|
|
POL
EILKEPVHGVY
497
11
40
63
7819
|
|
POL
KVRQYDQI
142
8
41
64
7820
|
|
POL
QIGCTLNF
179
8
41
64
7821
|
|
POL
EPVHGVYY
504
8
41
64
7822
|
|
POL
TQIGCTLNF
178
9
41
64
7823
|
|
POL
ILKEPVHGV
498
9
41
64
7824
|
|
POL
FIKVRQYDQI
140
10
41
64
7825
|
|
POL
QIGCTLNFPI
179
10
41
64
7826
|
|
POL
EILKEPVIIGV
497
10
41
64
7827
|
|
POL
TQIGCTLNFPI
178
11
41
64
7828
|
|
POL
KISKIGPENPY
235
11
41
64
7829
|
|
POL
SIVIWGKTPKF
571
11
41
64
7830
|
|
POL
EMEKEGKI
229
8
42
66
7831
|
|
POL
SPAIFQSSM
345
9
42
66
7832
|
|
POL
NQKTELQAI
666
9
42
66
7833
|
|
POL
IVIYQYMDDLY
367
11
42
66
7834
|
|
POL
YQIYQEPF
531
8
43
67
7835
|
|
POL
SMTKILEPF
352
9
43
67
7836
|
|
POL
QMAGDDCV
1027
8
44
69
7837
|
|
POL
KQMAGDDCV
1026
9
44
69
7838
|
|
POL
IQTKELQKQI
960
10
44
69
7839
|
|
POL
DIQTKELQKQI
959
11
44
69
7840
|
|
POL
EPFKNLKTGKY
536
11
45
70
7841
|
|
POL
DQAEHLKTAV
919
10
46
72
7842
|
|
POL
LPIQKETW
583
8
47
73
7843
|
|
POL
VIWGKTPKF
573
9
47
73
7844
|
|
POL
QITLWQRPLV
89
10
47
73
7845
|
|
POL
IVIWGKTPKF
572
10
47
73
7846
|
|
POL
PQITLWQRPLV
88
11
47
73
7847
|
|
POL
KLKPGMDGPKV
197
11
47
73
7848
|
|
POL
LVAVHVASGYI
826
11
47
73
7849
|
|
POL
TLWQRPLV
91
8
49
77
7850
|
|
POL
GLKKKKSVTV
288
10
49
77
7851
|
|
POL
GIRKVLFLDGI
747
11
49
77
7852
|
|
POL
KVLFLDGI
750
8
50
78
7853
|
|
POL
VPRRKAKII
1013
9
50
78
7854
|
|
POL
IIRDYGKQM
1020
9
50
78
7855
|
|
POL
VVPRRKAKII
1012
10
50
78
7856
|
|
POL
KIIRDYGKQM
1019
10
50
78
7857
|
|
POL
HPAGLKKKKSV
285
11
50
78
7858
|
|
POL
KVVPRRKAKII
1011
11
50
78
7859
|
|
POL
KIGPENPY
238
8
51
80
7860
|
|
POL
VPRRKAKI
1013
8
51
80
7861
|
|
POL
KPGMDGPKV
199
9
51
80
7862
|
|
POL
VVPRRKAKI
1012
9
51
80
7863
|
|
POL
GMDGPKVKQW
201
10
51
80
7864
|
|
POL
TPGIRYQYNV
328
10
51
80
7865
|
|
POL
VIYQYMDDLY
368
10
51
80
7866
|
|
POL
KVVPRRKAKI
1011
10
51
80
7867
|
|
POL
VLVGPTPVNII
162
11
51
80
7868
|
|
POL
VIYQYMDDLYV
368
11
51
80
7869
|
|
POL
WIPEWEFV
602
8
52
84
7870
|
|
POL
IQNFRVYY
972
8
52
84
7871
|
|
POL
GLKKKKSV
288
8
52
81
7872
|
|
POL
TPGIRYQY
328
8
52
81
7873
|
|
POL
GIRYQYNV
330
8
52
81
7874
|
|
POL
KIQNFRVY
971
8
52
81
7875
|
|
POL
KIQNFRVYY
971
9
52
81
7876
|
|
POL
LVGPTPVNII
163
10
52
81
7877
|
|
POL
WQATWIPEWEF
598
11
52
81
7878
|
|
POL
HVASGYIEAEV
830
11
52
81
7879
|
|
POL
VLVGPTPV
162
8
53
83
7880
|
|
POL
CQLKGEAM
795
8
53
83
7881
|
|
POL
SQGVVESM
899
8
53
83
7882
|
|
POL
TVLVGPTPV
161
9
53
83
7883
|
|
POL
AVHVASGYI
828
9
53
83
7884
|
|
POL
SMNKELKKI
905
9
53
83
7885
|
|
POL
VLVGPTPVNI
162
10
53
83
7886
|
|
POL
HPDKWTVQPI
424
10
53
83
7887
|
|
POL
ELELAENREI
489
10
53
83
7888
|
|
POL
LVAVHVASGY
826
10
53
83
7889
|
|
POL
PQSQGVVESM
897
10
53
83
7890
|
|
POL
SMNKELKKII
905
10
53
83
7891
|
|
POL
GIGGFIKVRQY
136
11
53
83
7892
|
|
POL
TVLVGPTPVNI
161
11
53
83
7893
|
|
POL
VLDVGDAYFSV
297
11
53
83
7894
|
|
POL
QLKGEAMHGQV
796
11
53
83
7895
|
|
POL
ILVAVHVASGY
825
11
53
83
7896
|
|
POL
NPQSQGVVESM
896
11
53
83
7897
|
|
POL
FVNTPPLV
608
8
54
86
7898
|
|
POL
FVNTPPLVKLW
608
11
54
86
7899
|
|
POL
GPTPVNII
165
8
54
84
7900
|
|
POL
LVGPTPVNI
163
9
54
84
7901
|
|
POL
DVGDAYFSV
299
9
54
84
7902
|
|
POL
WQATWIPEW
598
9
54
84
7903
|
|
POL
TVPVKLKPGM
193
10
54
84
7904
|
|
POL
FPISIETVPV
186
11
55
86
7905
|
|
POL
TQDFWEVQLGI
273
11
55
86
7906
|
|
POL
SPIETVPV
189
8
56
88
7907
|
|
POL
PVKLKPGM
195
8
56
88
7908
|
|
POL
WPLTEEKI
211
8
56
88
7909
|
|
POL
FPISPIETV
186
9
56
88
7910
|
|
POL
VPVKLKPGM
194
9
56
88
7911
|
|
POL
PISPIETVPV
187
10
56
88
7912
|
|
POL
KQWPLTEEKI
209
10
56
88
7913
|
|
POL
SVTVLDVGDAY
294
11
56
88
7914
|
|
POL
PISPIETV
187
8
57
89
7915
|
|
POL
ELAENREI
491
8
57
89
7916
|
|
POL
TPPLVKLW
611
8
57
89
7917
|
|
POL
PPLVKLWY
612
8
57
89
7918
|
|
POL
QVDCSPGI
805
8
57
89
7919
|
|
POL
HLKTAVQM
923
8
57
89
7920
|
|
POL
ELNKRTQDF
268
9
57
89
7921
|
|
POL
TVLDVGDAY
296
9
57
89
7922
|
|
POL
TPPLVKLWY
611
9
57
89
7923
|
|
POL
GQVDCSPGI
804
9
57
89
7924
|
|
POL
QVDCSPGIW
805
9
57
89
7925
|
|
POL
ELKKIIGQV
909
9
57
89
7926
|
|
POL
AIKKKDSTKW
251
10
57
89
7927
|
|
POL
ELNKRTQDFW
268
10
57
89
7928
|
|
POL
TVLDVGDAYF
296
10
57
89
7929
|
|
POL
GQVDCSPGIW
804
10
57
89
7930
|
|
POL
IILKTAVQMAV
923
10
57
89
7931
|
|
POL
IILKIAVQMAVF
923
11
57
89
7932
|
|
POL
GIGGYSAGERI
942
11
57
89
7933
|
|
POL
LPQGWKGSPAI
338
11
58
92
7934
|
|
POL
YVGSDLEI
377
8
58
91
7935
|
|
POL
DLYVGSDLEI
375
10
58
91
7936
|
|
POL
IVTDSQYALGI
687
11
58
91
7937
|
|
POL
IPAETGQETAY
841
11
58
91
7938
|
|
POL
FIHNFKRKGGI
933
11
58
91
7939
|
|
POL
SQYALGII
691
8
59
92
7940
|
|
POL
GIGGNEQV
733
8
59
92
7941
|
|
POL
AVIIVASGY
828
8
59
92
7942
|
|
POL
KLAGRWPV
855
8
59
92
7943
|
|
POL
NPQSQGVV
896
8
59
92
7944
|
|
POL
PQGWKGSPAI
339
10
59
92
7945
|
|
POL
EVNIVTDSQY
684
10
59
92
7946
|
|
POL
PQGWKGSPAIF
339
11
59
92
7947
|
|
POL
IPYNPQSQGVV
893
11
59
92
7948
|
|
POL
KLLWKGEGAVV
992
11
59
92
7949
|
|
POL
LLWKGEGAVVI
993
11
59
92
7950
|
|
POL
KPKMIGGI
130
8
60
94
7951
|
|
POL
VLDVGDAY
297
8
60
94
7952
|
|
POL
AVQMAVFI
927
8
60
94
7953
|
|
POL
VLDVGDAYF
297
9
60
94
7954
|
|
POL
ELHPDKWTV
422
9
60
94
7955
|
|
POL
KLNWASQIY
452
9
60
94
7956
|
|
POL
QMAVFIHNF
929
9
60
94
7957
|
|
POL
VQMAVFIHNF
928
10
60
94
7958
|
|
POL
KLLWKGEGAV
992
10
60
94
7959
|
|
POL
KPKMIGGIGGF
130
11
60
94
7960
|
|
POL
WMGYELHPDKW
418
11
60
94
7961
|
|
POL
LVGKLNWASQI
449
11
60
94
7962
|
|
POL
AVQMAVFIIINF
927
11
60
94
7963
|
|
POL
TLNFPISPI
183
9
61
97
7964
|
|
POL
YQYMDDLY
370
8
61
95
7965
|
|
POL
KLNWASQI
452
8
61
95
7966
|
|
POL
YQYMDDLYV
370
9
61
95
7967
|
|
POL
TVNDIQKLV
442
9
61
95
7968
|
|
POL
LLWKGEGAVV
993
10
61
95
7969
|
|
POL
ALLDTGADDTV
109
11
61
95
7970
|
|
POL
MIGGIGGF
133
8
62
97
7971
|
|
POL
KLVGKLNW
448
8
62
97
7972
|
|
POL
NIVTDSQY
686
8
62
97
7973
|
|
POL
KMIGGIGGF
132
9
62
97
7974
|
|
POL
MIGGIGGFI
133
9
62
97
7975
|
|
POL
IIQKEPPFLW
410
9
62
97
7976
|
|
POL
LLWKGEGAV
993
9
62
97
7977
|
|
POL
KMIGGIGGFI
132
10
62
97
7978
|
|
POL
HQKEPPFLWM
410
10
62
97
7979
|
|
POL
IQKLVGKLNW
446
10
62
97
7980
|
|
POL
MIGGIGGFIKV
133
11
62
97
7981
|
|
POL
DIQKLVGKLNW
445
11
62
97
7982
|
|
POL
WVPAHKGI
727
8
63
98
7983
|
|
POL
EPPFLWMGY
413
9
63
98
7984
|
|
POL
LLDTGADDTV
110
10
63
98
7985
|
|
POL
YQYNVLPQGW
333
10
63
98
7986
|
|
POL
IPYNPQSQGV
893
10
63
98
7987
|
|
POL
GIPYNPQSQGV
892
11
63
98
7988
|
|
POL
GIGGFIKV
136
8
64
100
7989
|
|
POL
PPFLWMGY
414
8
64
100
7990
|
|
REV
PQGTETGV
101
8
05
18
7991
|
|
REV
SQGTETGV
101
8
05
18
7992
|
|
REV
QPQGTETGV
100
9
05
18
7993
|
|
REV
CLGRPAEPV
67
9
10
16
7994
|
|
REV
TQGVGSPQI
98
9
11
18
7995
|
|
REV
LLKTVRLI
12
8
11
17
7996
|
|
REV
RQRQIHSI
52
8
11
17
7997
|
|
REV
VPLQLPPI
75
8
11
17
7998
|
|
REV
PVPLQLPPI
74
9
11
17
7999
|
|
REV
EPVPLQLPPI
73
10
11
17
8000
|
|
REV
AVRIIKILY
17
9
13
20
8001
|
|
REV
RQARKNRRRRW
39
11
16
25
8002
|
|
REV
IIKILYQSNPY
20
11
18
28
8003
|
|
REV
KILYQSNPY
22
9
26
41
8004
|
|
REV
ILYQSNPY
23
8
27
42
8005
|
|
REV
RQARRNRRRRW
39
11
38
59
8006
|
|
TAT
GPKESKKKV
90
9
13
20
8007
|
|
TAT
EPVDPRLEPW
2
10
13
20
8008
|
|
TAT
FLNKGLGI
41
8
14
22
8009
|
|
TAT
PVDPRLEPW
3
9
14
22
8010
|
|
TAT
EPVDPNLEPW
2
10
14
22
8011
|
|
TAT
FLNKGLGISY
41
10
14
22
8012
|
|
TAT
PVDPNLEPW
3
9
20
31
8013
|
|
VIF
ALIKPKKI
157
8
10
16
8014
|
|
VIF
PLGEARLVI
58
9
10
16
8015
|
|
VIF
QVDRMRINTW
12
10
10
16
8016
|
|
VIF
HIPLGDARLV
56
10
10
16
8017
|
|
VIF
IPLGEARLVI
57
10
10
16
8018
|
|
VIF
WQVDRMRINTW
11
11
10
16
8019
|
|
VIF
IIIPLGEARLVI
56
11
10
16
8020
|
|
VIF
GVSIEWRLRRY
87
11
10
16
8021
|
|
VIF
QIDPDLADQLI
102
11
10
16
8022
|
|
VIF
PLGDARLV
58
8
11
17
8023
|
|
VIF
IPLGDARLV
57
9
11
17
8024
|
|
VIF
SIEWRLRRY
89
9
11
17
8025
|
|
VIF
GLADQLIIIMIIY
106
11
11
17
8026
|
|
VIF
RLVITTYW
65
8
12
19
8027
|
|
VIF
LQTGERDW
74
8
12
19
8028
|
|
VIF
KIRTWNSLV
17
9
12
19
8029
|
|
VIF
GLQTGERDW
73
9
12
19
8030
|
|
VIF
IVWQVDRMKI
9
10
12
19
8031
|
|
VIF
QVDRMKIRTW
12
10
12
19
8032
|
|
VIF
WQVDRMKIRTW
11
11
12
19
8033
|
|
VIF
RMKIRTWNSLV
15
11
12
19
8034
|
|
VIF
WQVDRMKI
11
8
13
20
8035
|
|
VIF
HPKISSEV
48
8
13
20
8036
|
|
VIF
HPRISSEV
48
8
13
20
8037
|
|
VIF
DQLIHMIIY
109
8
13
20
8038
|
|
VIF
DQLIIIMIIYF
109
9
13
20
8039
|
|
VIF
IIPKISSEVHI
48
10
13
20
8040
|
|
VIF
IIPRISSEVIII
48
10
13
20
8041
|
|
VIF
SVKKLTEDRW
174
10
13
20
8042
|
|
VIF
QLIHLYYFDCF
110
11
13
20
8043
|
|
VIF
DQLIIILYY
109
8
14
22
8044
|
|
VIF
QLIIILYYF
110
8
14
22
8045
|
|
VIF
QLIIIMIIYF
110
8
14
22
8046
|
|
VIF
IVSPRCEY
133
8
14
22
8047
|
|
VIF
DQLIHLYYF
109
9
14
22
8048
|
|
VIF
QVDPGLADQLI
102
11
14
22
8049
|
|
VIF
QLIHMIIFPDCF
110
11
14
22
8050
|
|
VIF
KISSEVIII
50
8
15
23
8051
|
|
VIF
RISSEVIII
50
8
15
23
8052
|
|
VIF
HMIIYFDCF
113
8
15
23
8053
|
|
VIF
RIRTWKSLV
17
9
15
23
8054
|
|
VIF
RIRTWNSLV
17
9
15
23
8055
|
|
VIF
GLADQLIHM
106
9
15
23
8056
|
|
VIF
LIHMHYFDCF
111
10
15
23
8057
|
|
VIF
RMRIRTWKSLV
15
11
15
23
8058
|
|
VIF
RMRIRTWNSLV
15
11
15
23
8059
|
|
VIF
HLYYPDCF
113
8
16
25
8060
|
|
VIF
LIHLYYFDCF
111
10
16
25
8061
|
|
VIF
LVKIIIIMYI
24
8
19
30
8062
|
|
VIF
IIPKVSSEV
48
8
19
30
8063
|
|
VIF
PLGEARLV
58
8
19
30
8064
|
|
VIF
SLVKHIIMYI
23
9
19
30
8065
|
|
VIF
IPLGEARLV
57
9
19
30
8066
|
|
VIF
DPDLADQLI
104
9
19
30
8067
|
|
VIF
DPGLADQLI
104
9
19
30
8068
|
|
VIF
KIKPPLPSV
164
9
19
30
8069
|
|
VIF
IIPKYSSEVIII
48
10
19
30
8070
|
|
VIF
HIPLGEARLV
56
10
19
30
8071
|
|
VIF
KYSSEVIII
50
8
20
31
8072
|
|
VIF
LVKIIIIMYV
24
8
21
33
8073
|
|
VIF
SLVKIIIIMYV
23
9
21
33
8074
|
|
VIF
GLIITGERDW
73
9
22
34
8075
|
|
VIF
IILGIIGVSI
83
8
25
39
8076
|
|
VIF
IILGIIGVSIEW
83
10
25
39
8077
|
|
VIF
IILGQGVSI
83
8
26
41
8078
|
|
VIF
GQGVSIEW
85
8
26
41
8079
|
|
VIF
IILGQGVSIEW
83
10
26
41
8080
|
|
VIF
SLQYLALTALI
149
11
27
42
8081
|
|
VIF
YLALTALI
152
8
28
44
8082
|
|
VIF
LQYLALTALI
150
10
28
44
8083
|
|
VIF
QVDRMRIRTW
12
10
31
48
8084
|
|
VIF
WQVDRMRIRTW
11
11
31
48
8085
|
|
VIF
YQAGIINKV
140
8
38
59
8086
|
|
VIF
QVMIVWQV
6
8
43
67
8087
|
|
VIF
WQVMIVWQV
5
9
43
67
8088
|
|
VIF
QVMIVWQVDRM
6
11
43
67
8089
|
|
VIF
MIVWQVDRMRI
8
11
43
67
8090
|
|
VIF
SLVKHIIMY
23
8
44
69
8091
|
|
VIF
VMIVWQVDRM
7
10
44
69
8092
|
|
VIF
MIVWQVDRM
8
9
46
72
8093
|
|
VIF
IVWQVDRMRI
9
10
47
73
8094
|
|
VIF
WQVDRMRI
11
8
48
75
8095
|
|
VIF
IVWQVDRM
9
8
59
92
8096
|
|
VPR
RPWLHGLGQY
36
10
10
16
8097
|
|
VPR
QQLLPVHF
65
8
10
16
8098
|
|
VPR
LQQLLFVHF
64
9
10
16
8099
|
|
VPR
QLLFVHFRI
66
9
10
16
8100
|
|
VPR
QQLLFVHFRI
65
10
10
16
8101
|
|
VPR
LQQLLFVHFRI
64
11
10
16
8102
|
|
VPR
KQEAVRHF
27
8
11
17
8103
|
|
VPR
WLHGLGQY
38
8
11
17
8104
|
|
VPR
RIGCRHSRIGI
74
11
11
17
8105
|
|
VPR
RPWLHGLGQHI
36
11
12
19
8106
|
|
VPR
LLFVHFRI
67
8
12
19
8107
|
|
VPR
RIGCRHSRI
74
9
12
19
8108
|
|
VPR
GQHIYNTY
43
8
13
20
8109
|
|
VPR
AVRHFPRI
30
8
14
22
8110
|
|
VPR
GQYIYETY
43
8
14
22
8111
|
|
VPR
AVRHFPRIW
30
9
14
22
8112
|
|
VPR
HIYNTYGDTW
45
10
14
22
8113
|
|
VPR
YIYETYGDTW
45
10
14
22
8114
|
|
VPR
ELKSEAVRHF
25
10
15
23
8115
|
|
VPR
CQHSRIGII
77
9
16
25
8116
|
|
VPR
LLEELKSEAV
22
10
16
25
8117
|
|
VPR
ELLEELKNEAV
21
11
16
25
8118
|
|
VPR
ELLEELKSEAV
21
11
16
25
8119
|
|
VPR
GQIIIYETY
43
8
17
27
8120
|
|
VPR
LLEELKNEAV
22
10
17
27
8121
|
|
VPR
ELKNEAVRHF
25
10
17
27
8122
|
|
VPR
HIYETYGDTW
45
10
17
27
8123
|
|
VPR
WLIIGLGQIII
38
9
20
31
8124
|
|
VPR
WLIIGLGQIIIY
38
10
20
31
8125
|
|
VPR
IIRILQQLLFI
60
11
33
52
8126
|
|
VPR
GVEAIIRI
56
8
34
53
8127
|
|
VPR
AVRIIFPRPW
30
9
34
53
8128
|
|
VPR
RILQQLLFIIIF
62
11
34
53
8129
|
|
VPR
ILQQLLFIIIF
63
10
35
55
8130
|
|
VPR
RILQQLLFI
62
9
36
56
8131
|
|
VPR
ILQQLLFI
63
8
37
58
8132
|
|
VPR
PQREPYNEW
10
9
37
58
8133
|
|
VPR
GPQREPYNEW
9
10
37
58
8134
|
|
VPR
AIIRILQQLLF
59
11
38
59
8135
|
|
VPR
DQGPQREPY
7
9
41
64
8136
|
|
VPR
IIRILQQLLF
60
10
41
64
8137
|
|
VPR
QQLLFIHF
65
8
44
69
8138
|
|
VPR
LLFIHFRI
67
8
44
69
8139
|
|
VPR
LQQLLFIHF
64
9
44
69
8140
|
|
VPR
QLLFIHFRI
66
9
44
69
8141
|
|
VPR
QQLLFIIIFRI
65
10
44
69
8142
|
|
VPR
LQQLLFIIIFRI
64
11
44
69
8143
|
|
VPR
RILQQLLF
62
8
45
70
8144
|
|
VPR
CQHSRIGI
77
8
45
70
8145
|
|
VPR
RIGCQHSRIGI
74
11
45
70
8146
|
|
VPR
RIGCQHSRI
74
9
47
73
8147
|
|
VPU
KVDYRIVI
7
8
01
33
8148
|
|
VPU
KVDYRLGV
7
8
01
33
8149
|
|
VPU
RIDYRLGV
7
8
01
33
8150
|
|
VPU
KVDYRIVIV
7
9
01
33
8151
|
|
VPU
KVDYRIVIVAF
7
11
01
33
8152
|
|
VPU
GVEMGHHAPW
91
10
01
50
8153
|
|
VPU
RIKEIRDDSDY
64
11
01
50
8154
|
|
VPU
RIREIRDDSDY
64
11
01
50
8155
|
|
VPU
LIIAIVVW
26
8
10
16
8156
|
|
VPU
DQEELSALV
79
9
11
18
8157
|
|
VPU
ILAIVALVV
12
9
11
17
8158
|
|
VPU
EMGHHAPW
89
8
11
17
8159
|
|
VPU
ILAIVALV
12
8
12
19
8160
|
|
VPU
IVFIEYRKI
36
9
12
19
8161
|
|
VPU
VVWTIVFIEY
31
10
12
19
8162
|
|
VPU
IVVWTIVFIEY
30
11
12
19
8163
|
|
VPU
ILRQRKIDRLI
46
11
13
20
8164
|
|
VPU
AIVVWTIVF
29
9
14
22
8165
|
|
VPU
KIDRLIDRI
52
9
14
22
8166
|
|
VPU
AIVVWTIVFI
29
10
14
22
8167
|
|
VPU
IVVWTIVF
30
8
15
23
8168
|
|
VPU
VVWTIVFI
31
8
15
23
8169
|
|
VPU
KILRQRKI
45
8
15
23
8170
|
|
VPU
IVVWTIVFI
30
9
15
23
8171
|
|
VPU
RQRKIDRLI
48
9
17
27
8172
|
|
VPU
IIAIVVWTIV
27
10
20
31
8173
|
|
VPU
IIAIVVWTI
27
9
23
36
8174
|
|
VPU
AIVVWTIV
29
8
29
45
8175
|
|
TABLE XV
|
|
|
HIV A01 Motif Peptides with Binding Information
|
Con-
|
Se-
ser-
|
Po-
No. of
quence
van-
SEQ
|
Pro-
si-
Amino
Fre-
cy
ID
|
tein
Sequence
tion
Acids
quency
(%)
A*0101
NO.
|
|
ENV
IGSGQAFY
361
8
01
25
8176
|
|
ENV
GKDLWVTVY
42
9
01
33
8177
|
|
ENV
GKDLWVTVYY
42
10
01
33
8178
|
|
ENV
NTSPRSRVAY
376
10
01
33
8179
|
|
ENV
GTAGNSSRAA
375
11
01
33
8180
|
|
ENV
DSSNSTGNY
218
9
01
20
8181
|
|
ENV
TNSSYTNDTY
458
10
01
17
8182
|
|
ENV
WFDITNWLW
767
10
10
16
8183
|
|
ENV
WMEWEREIDN
723
11
10
16
8184
|
|
ENV
EWERLIDNY
725
9
11
17
8185
|
|
ENV
NMWQEVGKA
494
11
15
23
8186
|
|
ENV
IISFNCRGEFFY
434
11
16
25
8187
|
|
ENV
WQEVGKAMY
496
9
18
28
8188
|
|
ENV
VSFEPIPIIIY
253
10
28
44
8189
|
|
ENV
KVSFEPIPIIIY
252
11
28
44
8190
|
|
ENV
SFEPIPIIIY
254
9
31
48
8191
|
|
ENV
LQARVLAVER
662
11
33
52
8192
|
|
ENV
LSIVNRVRQGY
797
11
34
53
8193
|
|
ENV
RSLCLFSY
858
8
35
55
8194
|
|
ENV
LRSLCLFSY
857
9
35
55
8195
|
|
ENV
IISFNCGGEFFY
434
11
35
55
8196
|
|
ENV
DMRDNWRSEL
552
11
37
58
8197
|
|
ENV
MRDNWRSELY
553
10
40
63
0.0010
8198
|
|
ENV
CASDAKAY
67
8
42
66
8199
|
|
ENV
FCASDAKAY
66
9
42
66
8200
|
|
ENV
WRSELYKY
557
8
54
84
8201
|
|
GAG
ETIDKDLY
537
8
01
25
8202
|
|
GAG
EKEEKGLY
538
8
01
25
8203
|
|
GAG
KQEPIDKELY
535
10
01
25
8204
|
|
GAG
KQETIDKDLY
535
10
01
25
8205
|
|
GAG
AADKGVSQNY
130
10
01
50
8206
|
|
GAG
ASAQQDLKGG
392
11
01
50
8207
|
|
GAG
ATAQQDLKGG
392
11
01
50
8208
|
|
GAG
AADKGKVSQN
129
11
02
18
8209
|
|
GAG
EADGKVSQNY
129
10
04
36
8210
|
|
GAG
GNSSQVSQNY
140
10
12
23
8211
|
|
GAG
KQEPIDKELY
531
10
12
19
8212
|
|
GAG
SEELRSLY
74
8
12
19
8213
|
|
GAG
GSEELRSLY
73
9
12
19
8214
|
|
GAG
TGSEELRSLY
72
10
12
19
8215
|
|
GAG
NSSQVSQNY
144
9
14
31
8216
|
|
GAG
SSQVSQNY
145
8
15
31
8217
|
|
GAG
RSLYNTVATL
78
11
15
24
8218
|
|
GAG
FRDYVDRFY
317
9
29
45
0.0900
8219
|
|
GAG
PKEPFRDY
313
8
63
98
8220
|
|
NEF
IIMARELIIPEY
320
10
10
16
8221
|
|
NEF
IIMARELIIPEY
320
11
10
16
8222
|
|
NEF
ARELIIPEFY
322
9
11
17
8223
|
|
NEF
YTPGPGIRY
207
9
17
27
8224
|
|
NEF
RQDILDLWVY
182
10
20
31
8225
|
|
NEF
ARELHPEVY
322
9
21
33
8226
|
|
NEF
ARELHPEY
322
8
24
38
8227
|
|
NEF
RQEILDLWVY
182
10
32
50
8228
|
|
POL
TWETWWTDY
589
9
10
16
8229
|
|
POL
TWETWWTEY
589
9
10
16
8230
|
|
POL
ETWETWWTD
588
10
10
16
8231
|
|
POL
ETWETWWTE
588
10
10
16
8232
|
|
POL
AQEDHEKY
760
8
11
17
8233
|
|
POL
ISRIGPENPY
236
10
11
17
8234
|
|
POL
KISRIGPENPY
235
11
11
17
8235
|
|
POL
STNNETPGIRY
323
11
11
17
8236
|
|
POL
KTELQAIY
668
8
12
19
8237
|
|
POL
GQDQWTYQIY
525
10
12
19
8238
|
|
POL
DKAQEEHERY
758
10
15
23
8239
|
|
POL
AQEEIIERY
760
8
16
25
8240
|
|
POL
NPDIVIYQY
364
9
17
27
0.0011
8241
|
|
POL
PLDKDFRKY
308
9
19
30
8242
|
|
POL
QQEFGIPY
888
8
20
32
8243
|
|
POL
NPEIVIYQY
364
9
23
36
8244
|
|
POL
DKAQEEIIEKY
758
10
25
39
8245
|
|
POL
AQEEIIEKY
760
8
27
42
8246
|
|
POL
KQEFGIPY
888
8
28
44
8247
|
|
POL
NRETKLGKAG
639
11
28
44
8248
|
|
POL
ETKLGKAGY
641
9
35
55
0.0010
8249
|
|
POL
ITKIQNFRVY
969
10
36
57
0.0010
8250
|
|
POL
ITKIQNFRVYY
969
11
36
57
0.0110
8251
|
|
POL
LKEPVHGVYY
502
10
39
61
0.0010
8252
|
|
POL
LKEPVHGVY
502
9
41
64
0.0007
8253
|
|
POL
RKAKIIRDY
1016
9
41
64
8254
|
|
POL
KISKIGPENPY
235
11
41
64
8255
|
|
POL
ISKIGPENPY
236
10
42
66
0.0130
8256
|
|
POL
NNETPGIRY
325
9
51
80
0.0007
8257
|
|
POL
NNETPGIRYQY
325
11
51
80
0.0004
8258
|
|
POL
ETPGIRYQY
327
9
52
81
0.0052
8259
|
|
POL
LVAVIIVASGY
826
10
53
83
0.0390
8260
|
|
POL
VTVLDVGDAY
295
10
56
88
0.2800
8261
|
|
POL
NTPPLVKLWY
610
10
57
89
0.0041
8262
|
|
POL
PAETGQETAY
842
10
58
91
0.0130
8263
|
|
POL
IPAETGQETAY
841
11
58
91
8264
|
|
POL
IETGQETAY
844
8
59
92
8265
|
|
POL
VLDVGDAY
297
8
60
94
8266
|
|
POL
QKEPPFLWMG
411
11
63
98
0.0004
8267
|
|
VIF
GVSIEWRLRR
87
11
10
16
8268
|
|
VIF
SIEWRLRRY
89
9
11
17
8269
|
|
VIF
VSIEWRLRRY
88
10
11
17
8270
|
|
VIF
GLADQLIHMH
106
11
11
17
8271
|
|
VIF
LADQLIHMHY
107
10
13
20
8272
|
|
VIF
IVSPRCEY
133
8
14
22
8273
|
|
VIF
LADQLIHLYY
107
10
14
22
8274
|
|
VIF
LADQLIIILY
107
9
15
23
8275
|
|
VIF
KSLVKHIIMY
22
9
18
28
8276
|
|
VIF
WKSLVKIIIIM
21
10
18
28
8277
|
|
VIF
NSLVKIIHMY
22
9
24
38
8278
|
|
VIF
WNSLVKHIIM
21
10
24
38
8279
|
|
VPR
PEDQGPQREPY
5
11
37
58
8280
|
|
VPU
WTIVFIEY
34
8
12
19
8281
|
|
TABLE XVI
|
|
|
+UZ,/37 HIV A03 Motif Peptides with Binding Information
|
No. of
SEQ
|
Amino
Sequence
Conservancy
ID
|
Protein
Sequence
Position
Acids
Frequency
(%)
A0301
NO.
|
|
ENV
GIGPGQTF
360
8
01
33
8282
|
|
ENV
SIGSGQAF
360
8
01
33
8283
|
|
ENV
IGPGQTFY
361
8
01
25
8284
|
|
ENV
IGSGQAFY
361
8
01
25
8285
|
|
ENV
GTAGNSSR
375
8
01
33
8286
|
|
ENV
TAGNSSRA
376
8
01
33
8287
|
|
ENV
KLREIRQF
405
8
01
25
8288
|
|
ENV
ADNLWVTVY
42
9
01
33
8289
|
|
ENV
GIGPGQTFY
360
9
01
33
8290
|
|
ENV
SIGSGQAFY
360
9
01
33
8291
|
|
ENV
IGPGQTFYA
361
9
01
25
8292
|
|
ENV
GTAGNSSRA
375
9
01
33
8293
|
|
ENV
NTSPRSRVA
376
9
01
33
8294
|
|
ENV
TAGNSSRAA
376
9
01
33
8295
|
|
ENV
ADNLWVTVYY
42
10
01
33
8296
|
|
ENV
EGKNEINDTY
217
10
01
33
8297
|
|
ENV
GIGPGQTFYA
360
10
01
33
8298
|
|
ENV
GTAGNSSRAA
375
10
01
33
8299
|
|
ENV
NTSPRSRVAY
376
10
01
33
8300
|
|
ENV
TAGNSSRAAY
376
10
01
33
8301
|
|
ENV
FGLGALFLGF
597
10
01
33
8302
|
|
ENV
VGLGAVFLGF
597
10
01
33
8303
|
|
ENV
GTAGNSSRAA
375
11
01
33
8304
|
|
ENV
KLREIRQFENK
405
11
01
25
8305
|
|
ENV
QLYATVYA
34
8
01
50
8306
|
|
ENV
IINIHTPH
584
8
01
50
8307
|
|
ENV
VISTRTHR
584
8
01
50
8308
|
|
ENV
STRTHREK
586
8
01
50
8309
|
|
ENV
NANITIPCR
478
9
01
50
8310
|
|
ENV
IINIHTPIIR
584
9
01
50
8311
|
|
ENV
ISTRTIIREK
585
9
01
50
8312
|
|
ENV
NIIITPHREK
586
9
01
50
8313
|
|
ENV
STRTHREKR
586
9
01
50
8314
|
|
ENV
VISTRTIIREK
584
10
01
50
8315
|
|
ENV
ISTRTIIREKR
585
10
01
50
8316
|
|
ENV
NIHTPHREKR
586
10
01
50
8317
|
|
ENV
STRTHREKRA
586
10
01
50
8318
|
|
ENV
IITEGNITLQCR
478
11
01
50
8319
|
|
ENV
NANITIPCRIK
478
11
01
50
8320
|
|
ENV
IINIHTPHREK
584
11
01
50
8321
|
|
ENV
VISTRTHREKR
584
11
01
50
8322
|
|
ENV
ISTRTHREKRA
585
11
01
50
8323
|
|
ENV
NIHTPHREKRA
586
11
01
50
8324
|
|
ENV
VTSTGNSA
161
8
01
20
8325
|
|
ENV
DSSNSTGNY
218
9
01
20
8326
|
|
ENV
STNGTETF
537
8
01
17
8327
|
|
ENV
STNGTETFR
537
9
01
17
8328
|
|
ENV
NDTENNTEIF
537
10
01
17
8329
|
|
ENV
NTETNKTETF
537
10
01
17
8330
|
|
ENV
NTTGNTTETF
537
10
01
17
8331
|
|
ENV
NDTENNTEIFR
537
11
01
17
8332
|
|
ENV
NTETNKTETF
537
11
01
17
8333
|
|
ENV
NTTGNTTETF
537
11
01
17
8334
|
|
ENV
NGSENGTETF
537
10
02
33
8335
|
|
ENV
NGSENGTETF
537
11
02
33
8336
|
|
ENV
GSENGTETF
538
9
02
18
8337
|
|
ENV
GSENGTETFR
538
10
02
18
8338
|
|
ENV
TIGAMFLGF
599
9
03
27
8339
|
|
ENV
NDTITLPCR
477
9
03
20
8340
|
|
ENV
NDTITLPCRIK
477
11
03
20
8341
|
|
ENV
MLGAMFLGF
599
9
04
36
8342
|
|
ENV
RGWEALKY
895
8
06
19
8343
|
|
ENV
KGLRLGWEGL
891
11
08
27
8344
|
|
ENV
LGWEGLKY
895
8
09
29
8345
|
|
ENV
RLGWEGLKY
894
9
09
29
8346
|
|
ENV
GLRLGWEGLK
892
11
09
29
8347
|
|
ENV
LGRRGWEALK
883
10
09
15
8348
|
|
ENV
LLGRRGWEAL
882
11
09
15
8349
|
|
ENV
EIIGDIRQA
372
9
09
15
8350
|
|
ENV
LILGLVIICSA
21
11
09
15
8351
|
|
ENV
TGEIIGDIRQA
370
11
09
15
8352
|
|
ENV
RLGWEGLK
894
8
10
32
8353
|
|
ENV
GLRLGWEGLK
892
10
10
32
8354
|
|
ENV
LGRRGWEA
883
8
10
16
8355
|
|
ENV
LLGRRGWEA
882
9
10
16
8356
|
|
ENV
DIIGDIRQAH
372
10
10
16
8357
|
|
ENV
ELLGRRGWEA
881
10
10
16
8358
|
|
ENV
TGDIIGDIRQA
370
11
10
16
8359
|
|
ENV
GLVIICSA
28
8
10
16
8360
|
|
ENV
RVGQAMYA
498
8
10
16
8361
|
|
ENV
PLGVAPTR
571
8
10
16
8362
|
|
ENV
LGVAPTRA
572
8
10
16
8363
|
|
ENV
DITNWLWY
769
8
10
16
8364
|
|
ENV
RDFILIAA
869
8
10
16
8365
|
|
ENV
DFILIAAR
870
8
10
16
8366
|
|
ENV
DTIAIAVA
923
8
10
16
8367
|
|
ENV
LGLVIICSA
27
9
10
16
8368
|
|
ENV
STITQACPK
243
9
10
16
8369
|
|
ENV
IGPGQTFYA
358
9
10
16
8370
|
|
ENV
FDITNWLWY
768
9
10
16
8371
|
|
ENV
RDFILIAAR
869
9
10
16
8372
|
|
ENV
NSAVSLLNA
916
9
10
16
8373
|
|
ENV
ILGLVIICSA
26
10
10
16
8374
|
|
ENV
LLGMLMICSA
26
10
10
16
8375
|
|
ENV
PIHYCTPAGF
260
10
10
16
8376
|
|
ENV
FAILKCNDKK
269
10
10
16
8377
|
|
ENV
RIGPGQTFYA
357
10
10
16
8378
|
|
ENV
MLQLTVWGIK
651
10
10
16
8379
|
|
ENV
RVLAVERYLR
665
10
10
16
8380
|
|
ENV
WFDITNWLW
767
10
10
16
8381
|
|
ENV
EGIEEEGGER
828
10
10
16
8382
|
|
ENV
PIIIYCTPAGFA
260
11
10
16
8383
|
|
ENV
GFAILKCNDKK
268
11
10
16
8384
|
|
ENV
FAILKCNDKKF
269
11
10
16
8385
|
|
ENV
GDIIGDIRQAH
371
11
10
16
8386
|
|
ENV
NVPWNSSWSN
693
11
10
16
8387
|
|
ENV
WMEWEREIDN
723
11
10
16
8388
|
|
ENV
NSAVSLLNAT
916
11
10
16
8389
|
|
ENV
IAIAVAEGTDR
925
11
10
16
8390
|
|
ENV
RGWEALKY
886
8
11
18
8391
|
|
ENV
GIGAVFLGF
598
9
11
18
8392
|
|
ENV
KLWVTVYY
44
8
11
17
8393
|
|
ENV
AVGIGAVF
595
8
11
17
8394
|
|
ENV
RAVGIGAVF
594
9
11
17
8395
|
|
ENV
AVGIGAVFLGF
595
11
11
17
8396
|
|
ENV
TITQACPK
244
8
11
17
8397
|
|
ENV
YCTPAGFA
263
8
11
17
8398
|
|
ENV
RIGPGQTF
357
8
11
17
8399
|
|
ENV
IGPGQTFY
358
8
11
17
8400
|
|
ENV
LFLGFLGA
603
8
11
17
8401
|
|
ENV
LAVERYLR
667
8
11
17
8402
|
|
ENV
NLCLFSYII
859
8
11
17
8403
|
|
ENV
SAVSLLNA
917
8
11
17
8404
|
|
ENV
VSLLNATA
919
8
11
17
8405
|
|
ENV
LGMLMICSA
27
9
11
17
8406
|
|
ENV
RIGPGQTFY
357
9
11
17
8407
|
|
ENV
ITTHSFNCR
431
9
11
17
8408
|
|
ENV
NITLPCRIK
482
9
11
17
8409
|
|
ENV
ALFLGFLGA
602
9
11
17
8410
|
|
ENV
LFLGFLGAA
603
9
11
17
8411
|
|
ENV
VLAVERYLR
666
9
11
17
8412
|
|
ENV
ISNWLWYIK
770
9
11
17
8413
|
|
ENV
NLCLFSYIIR
859
9
11
17
8414
|
|
ENV
AVSLLNATA
918
9
11
17
8415
|
|
ENV
GDIIGDIRQA
371
10
11
17
8416
|
|
ENV
EITTHSFNCR
430
10
11
17
8417
|
|
ENV
VGIGAVFLGF
596
10
11
17
8418
|
|
ENV
GALFLGFLGA
601
10
11
17
8419
|
|
ENV
ALFLGFLGAA
602
10
11
17
8420
|
|
ENV
SAVSLLNATA
917
10
11
17
8421
|
|
ENV
VSLLNATAIA
919
10
11
17
8422
|
|
ENV
YATGDIIGDIR
368
11
11
17
8423
|
|
ENV
GALFLGFLGAA
601
11
11
17
8424
|
|
ENV
ISNWLWYIKIF
770
11
11
17
8425
|
|
ENV
DLRNLCLFSYH
856
11
11
17
8426
|
|
ENV
NLCLFSYHRLR
859
11
11
17
8427
|
|
ENV
AVSLLNATAIA
918
11
11
17
8428
|
|
ENV
PTRIRQGLERA
951
11
11
17
8429
|
|
ENV
TGDIIGDIR
370
9
12
19
8430
|
|
ENV
DIIGDIRQA
372
9
12
19
8431
|
|
ENV
EAQQIILLK
646
8
12
19
8432
|
|
ENV
GMLMICSA
28
8
12
19
8433
|
|
ENV
ILKCNDKK
271
8
12
19
8434
|
|
ENV
TTHSFNCR
432
8
12
19
8435
|
|
ENV
IGAVFLGF
600
8
12
19
8436
|
|
ENV
MTWMEWER
721
8
12
19
8437
|
|
ENV
GGERDRDR
834
8
12
19
8438
|
|
ENV
AILKCNDKK
270
9
12
19
8439
|
|
ENV
ILKCNDKKF
271
9
12
19
8440
|
|
ENV
LAEEEVVIR
312
9
12
19
0.0002
8441
|
|
ENV
AMFLGFLGA
602
9
12
19
8442
|
|
ENV
NMTWMEWER
720
9
12
19
8443
|
|
ENV
GIEEEGGER
829
9
12
19
8444
|
|
ENV
EGGERDRDR
833
9
12
19
8445
|
|
ENV
RSIRLVNGF
841
9
12
19
8446
|
|
ENV
WGQELKNSA
910
9
12
19
8447
|
|
ENV
WSQELKNSA
910
9
12
19
8448
|
|
ENV
KTTLFCASDA
60
10
12
19
8449
|
|
ENV
AILKCNDKKF
270
10
12
19
8450
|
|
ENV
SLAEEEVVIR
311
10
12
19
8451
|
|
ENV
ATGDIIGDIR
369
10
12
19
8452
|
|
ENV
IINMWQEVGK
492
10
12
19
8453
|
|
ENV
GAMFLGFLGA
601
10
12
19
8454
|
|
ENV
AMFLGFLGAA
602
10
12
19
8455
|
|
ENV
AIEAQQHLLK
644
10
12
19
8456
|
|
ENV
QDLLALDKWA
753
10
12
19
8457
|
|
ENV
SIRLVSGFLA
842
10
12
19
8458
|
|
ENV
LLQYWSQELK
906
10
12
19
8459
|
|
ENV
AILHIPRRIR
946
10
12
19
8460
|
|
ENV
PTRIRQGLER
951
10
12
19
8461
|
|
ENV
KTTLFCASDA
60
11
12
19
8462
|
|
ENV
GSLAEEEVVIR
310
11
12
19
8463
|
|
ENV
TTIISFNCRGE
432
11
12
19
8464
|
|
ENV
QIINMWQEVG
491
11
12
19
8465
|
|
ENV
IINMWQEVGK
492
11
12
19
8466
|
|
ENV
GAMFLGFLGA
601
11
12
19
8467
|
|
ENV
ITKWLWYIKIF
770
11
12
19
8468
|
|
ENV
GIEEEGGERDR
829
11
12
19
8469
|
|
ENV
RSIRLVSGFLA
841
11
12
19
8470
|
|
ENV
NLLQYWSQEL
905
11
12
19
8471
|
|
ENV
RAILHIPRRIR
945
11
12
19
8472
|
|
ENV
NTSVITQA
241
8
13
20
8473
|
|
ENV
SVEINCTR
340
8
13
20
8474
|
|
ENV
GDIIGDIR
371
8
13
20
8475
|
|
ENV
MFLGFLGA
603
8
13
20
8476
|
|
ENV
KLTVWGIK
653
8
13
20
8477
|
|
ENV
SIRLVNGF
842
8
13
20
8478
|
|
ENV
SIRLVSGF
842
8
13
20
8479
|
|
ENV
RLVNGFLA
844
8
13
20
8480
|
|
ENV
RAILHIPR
945
8
13
20
8481
|
|
ENV
AILIIIPRR
946
8
13
20
8482
|
|
ENV
KAKRRVVQR
579
9
13
20
0.0002
8483
|
|
ENV
MFLGFLGAA
603
9
13
20
8484
|
|
ENV
RSIRLVSGF
841
9
13
20
8485
|
|
ENV
RAILIIIPRR
945
9
13
20
8486
|
|
ENV
ILIIIPRRIR
947
9
13
20
8487
|
|
ENV
SGGDPEIVMH
425
10
13
20
8488
|
|
ENV
LLKLTVWGIK
651
10
13
20
8489
|
|
ENV
NTSVITQACPK
241
11
13
20
8490
|
|
ENV
CTNVSTVQCT
285
11
13
20
8491
|
|
ENV
SSGGDLEITTH
424
11
13
20
8492
|
|
ENV
SSGGDPEIVMII
424
11
13
20
8493
|
|
ENV
VMHSFNCGGE
432
11
13
20
8494
|
|
ENV
PTKAKRRVVQ
576
11
13
20
8495
|
|
ENV
KAKRRVVQRE
579
11
13
20
8496
|
|
ENV
IILLKLTVWGI
650
11
13
20
8497
|
|
ENV
VGGLIGLRIIF
784
11
13
20
8498
|
|
ENV
SLLNATAIAVA
920
11
13
20
8499
|
|
ENV
TGEIIGDIR
370
9
14
23
8500
|
|
ENV
NTSAITQA
241
8
14
22
8501
|
|
ENV
AITQACPK
244
8
14
22
8502
|
|
ENV
GDPEIVMII
427
8
14
22
8503
|
|
ENV
QDLLALDK
753
8
14
22
8504
|
|
ENV
NATAIAVA
923
8
14
22
8505
|
|
ENV
SAITQACPK
243
9
14
22
8506
|
|
ENV
FAILKCNDK
269
9
14
22
0.0002
8507
|
|
ENV
GGDPEIVMH
426
9
14
22
8508
|
|
ENV
TITLPCRIK
482
9
14
22
8509
|
|
ENV
SLLNATAIA
920
9
14
22
8510
|
|
ENV
NCNTSAITQA
239
10
14
22
8511
|
|
ENV
TSAITQACPK
242
10
14
22
8512
|
|
ENV
TSVITQACPK
242
10
14
22
8513
|
|
ENV
GFAILKCNDK
268
10
14
22
8514
|
|
ENV
GDPEIVMHSF
427
10
14
22
8515
|
|
ENV
IFAVLSIVNR
793
10
14
22
8516
|
|
ENV
LLNATAIAVA
921
10
14
22
8517
|
|
ENV
NTSAITQACPK
241
11
14
22
8518
|
|
ENV
VITQACPKVSF
244
11
14
22
8519
|
|
ENV
AGFAILKCNDK
267
11
14
22
8520
|
|
ENV
GGDPEIVMIISF
426
11
14
22
8521
|
|
ENV
ITNWLWYIKIF
770
11
14
22
8522
|
|
ENV
IIFAVLSIVNR
792
11
14
22
8523
|
|
ENV
KIEPLGVAPTK
568
11
15
24
8524
|
|
ENV
FDPIPIHY
255
8
15
23
8S25
|
|
ENV
PAGYAILK
266
8
15
23
8526
|
|
ENV
NMWQEVGK
494
8
15
23
8527
|
|
ENV
LLNATAIA
921
8
15
23
8528
|
|
ENV
NMWQEVGKA
494
9
15
23
8529
|
|
ENV
DLLALDKWA
754
9
15
23
8530
|
|
ENV
ITNWLWYIK
770
9
15
23
8531
|
|
ENV
GLIGLRIIF
786
9
15
23
8532
|
|
ENV
DDLRNLCLF
855
9
15
23
8533
|
|
ENV
SGGDLEITTH
425
10
15
23
8534
|
|
ENV
IFRPGGGDMR
545
10
15
23
8535
|
|
ENV
GGLIGLRIIF
785
10
15
23
8536
|
|
ENV
GLICLRIIFA
786
10
15
23
8537
|
|
ENV
WDDLRNLCLF
854
10
15
23
8538
|
|
ENV
NMWQEVGKA
494
11
15
23
8539
|
|
ENV
EIFRPGGGDMR
544
11
15
23
8540
|
|
ENV
GGLIGLRIIFA
785
11
15
23
8541
|
|
ENV
DDLRNLCLFSY
855
11
15
23
8542
|
|
ENV
SFNCRGEF
437
8
16
25
8543
|
|
ENV
LIGLRIIF
787
8
16
25
8544
|
|
ENV
VSGFLALA
846
8
16
25
8545
|
|
ENV
HSFNCRGEF
434
9
16
25
8546
|
|
ENV
SFNCRGEFF
437
9
16
25
8547
|
|
ENV
ITKWLWYIK
770
9
16
25
8548
|
|
ENV
LIGLRIIFA
787
9
16
25
8549
|
|
ENV
LVSGFLALA
845
9
16
25
8550
|
|
ENV
IISFNCRGEFE
434
10
16
25
8551
|
|
ENV
SFNCRGEFFY
437
10
16
25
8552
|
|
ENV
RLVSGFLALA
844
10
16
25
8553
|
|
ENV
DLRNLCLFSY
856
10
16
25
8554
|
|
ENV
TTIISFNCGGE
432
11
16
25
8555
|
|
ENV
IISFNCRGEFFY
434
11
16
25
8556
|
|
ENV
RLINCNTSA
236
9
17
27
8557
|
|
ENV
KAYDTEVH
72
8
17
27
8558
|
|
ENV
LINCNTSA
237
8
17
27
8559
|
|
ENV
VITQACPK
244
8
17
27
8560
|
|
ENV
RVVQREKR
587
8
17
27
0.0003
8561
|
|
ENV
VVQREKRA
588
8
17
27
8562
|
|
ENV
IGLRIIFA
788
8
17
27
8563
|
|
ENV
DLRNLCLF
856
8
17
27
8564
|
|
ENV
SVITQACPK
243
9
17
27
8565
|
|
ENV
VAPTKAKRR
574
9
17
27
0.0002
8566
|
|
ENV
RVVQREKRA
587
9
17
27
8567
|
|
ENV
DAKAYDTEVII
70
10
17
27
8568
|
|
ENV
YDTEVIINVWA
74
10
17
27
8569
|
|
ENV
GVAPTKAKRR
573
10
17
27
8570
|
|
ENV
VFAVLSIVNR
793
10
17
27
8571
|
|
ENV
SDAKAYDTEV
69
11
17
27
8572
|
|
ENV
DTEVHNVWAT
75
11
17
27
8573
|
|
ENV
NCTRPNNNTR
344
11
17
27
8574
|
|
ENV
LGVAPTKAKR
S72
11
17
27
8575
|
|
ENV
IVFAVLSIVNR
792
11
17
27
8576
|
|
ENV
PIHYCTPA
260
8
18
28
8577
|
|
ENV
EVGKAMYA
498
8
18
28
8578
|
|
ENV
DTEVIINVWA
75
9
18
28
8579
|
|
ENV
VLAVERYLK
666
9
18
28
8580
|
|
ENV
ELLELDKWA
754
9
18
28
8581
|
|
ENV
FSYIIRLRDF
863
9
18
28
8582
|
|
ENV
PIPIIIYCTPA
258
10
18
28
8583
|
|
ENV
RVLAVERYLK
665
10
18
28
8584
|
|
ENV
LFSYHRLRDF
862
10
18
28
8585
|
|
ENV
CLFSYHRLRDF
861
11
18
28
8586
|
|
ENV
NCRGEFFY
439
8
19
30
8587
|
|
ENV
GVAPTKAK
573
8
19
30
8588
|
|
ENV
VAPTKAKR
574
8
19
30
8589
|
|
ENV
VFLGFLGA
603
8
19
30
8590
|
|
ENV
LLALDKWA
755
8
19
30
8591
|
|
ENV
LGVAPTKAK
572
9
19
30
8592
|
|
ENV
GVAPTKAKR
573
9
19
30
8593
|
|
ENV
AVFLGFLGA
602
9
19
30
8594
|
|
ENV
VFLGFLGAA
603
9
19
30
8595
|
|
ENV
SGKLICTTA
685
9
19
30
8596
|
|
ENV
PLGVAPTKAK
571
10
19
30
8597
|
|
ENV
LGVAPTKAKR
572
10
19
30
8598
|
|
ENV
GAVFLGFLGA
601
10
19
30
8599
|
|
ENV
AVFLGFLGAA
602
10
19
30
8600
|
|
ENV
CSGKLICTTA
684
10
19
30
8601
|
|
ENV
SSNITGLLLTR
516
11
19
30
8602
|
|
ENV
PLGVAPTKAK
571
11
19
30
8603
|
|
ENV
GAVFLGFLGA
601
11
19
30
8604
|
|
ENV
GCSGKLICTTA
683
11
19
30
8605
|
|
ENV
AILKCNDK
270
8
20
31
8606
|
|
ENV
RLVSGFLA
844
8
20
31
8607
|
|
ENV
ETFRPGGGDM
544
11
20
31
8608
|
|
ENV
LIEESQNQQEK
740
11
20
31
8609
|
|
ENV
GDLEITTII
427
8
21
33
8610
|
|
ENV
YCNTSGLF
446
8
21
33
8611
|
|
ENV
LLELDKWA
755
8
21
33
8612
|
|
ENV
GGDLEITTH
426
9
21
33
8613
|
|
ENV
DLEITTHSF
428
9
21
33
8614
|
|
ENV
LIGLRIVFA
787
9
21
33
8615
|
|
ENV
GDLEITTIISF
427
10
21
33
8616
|
|
ENV
FFYCNTSGLF
444
10
21
33
8617
|
|
ENV
GLIGLRIVFA
786
10
21
33
8618
|
|
ENV
SFEPIPIIIYCA
254
11
21
33
8619
|
|
ENV
GGDLEITTHSF
426
11
21
33
8620
|
|
ENV
EFFYCNTSGLF
443
11
21
33
8621
|
|
ENV
GGLIGLRIVFA
785
11
21
33
8622
|
|
ENV
TAIAVAEGTDR
925
11
21
33
8623
|
|
ENV
IGLRIVFA
788
8
22
34
8624
|
|
ENV
RIVELLGR
878
8
22
34
8625
|
|
ENV
IVELLGRR
879
8
22
34
8626
|
|
ENV
RIVELLGRR
878
9
22
34
0.0550
8627
|
|
ENV
NCTRPNNNTR
344
10
22
34
8628
|
|
ENV
CTRPNNNTRK
345
10
22
34
8629
|
|
ENV
PVWKEATTTL
54
11
22
34
8630
|
|
ENV
TTTLFCASDA
60
11
22
34
8631
|
|
ENV
KIEPLGVA
568
8
23
37
8632
|
|
ENV
LGVAPTKA
572
8
23
36
8633
|
|
ENV
TVQCTIIGIR
290
9
23
36
0.0008
8634
|
|
ENV
PLGVAPTKA
571
9
23
36
8635
|
|
ENV
STVQCTHGIR
289
10
23
36
8636
|
|
ENV
VVKIEPLGVA
566
10
23
36
8637
|
|
ENV
QSNLLRAIEA
638
10
23
36
8638
|
|
ENV
ATTTLFCASD
59
11
23
36
8639
|
|
ENV
VSTVQCTIIGIR
288
11
23
36
8640
|
|
ENV
KVVKIEPLGVA
565
11
23
36
8641
|
|
ENV
ATTTLFCA
59
8
24
38
8642
|
|
ENV
EATTTLFCA
58
9
24
38
8643
|
|
ENV
TTTLFCASDA
60
10
24
38
8644
|
|
ENV
TFRPGGGDMR
545
10
24
38
8645
|
|
ENV
ALAWDDLR
851
8
25
39
8646
|
|
ENV
LALAWDDLR
850
9
25
39
8647
|
|
ENV
IVQQQNNLLR
634
10
25
39
0.0024
8648
|
|
ENV
FLALAWDDLR
849
10
25
39
8649
|
|
ENV
GIVQQQNNLLR
633
11
25
39
8650
|
|
ENV
IVQQQNNLLRA
634
11
25
39
8651
|
|
ENV
GFLALAWDDL
848
11
25
39
8652
|
|
ENV
ITLPCRIK
483
8
26
41
8653
|
|
ENV
PLGVAPTK
571
8
26
41
8654
|
|
ENV
LAVERYLK
667
8
26
41
8655
|
|
ENV
IVQQQSNLLR
634
10
26
41
8656
|
|
ENV
GIVQQQSNLLR
633
11
26
41
8657
|
|
ENV
IVQQQSNLLRA
634
11
26
41
8658
|
|
ENV
LDKWASLWN
758
11
26
41
8659
|
|
ENV
IIGDIRQAH
377
9
27
44
8660
|
|
ENV
ESQNQQEK
743
8
27
42
8661
|
|
ENV
PIIIYCAPAGF
260
10
27
42
8662
|
|
ENV
PIIIYCAPAGFA
260
11
27
42
8663
|
|
ENV
VGGLIGLRIVF
784
11
27
42
8664
|
|
ENV
IGDIRQAII
378
8
28
44
8665
|
|
ENV
YCAPAGFA
263
8
28
44
8666
|
|
ENV
TVQCTIIGIK
290
9
28
44
0.0021
8667
|
|
ENV
CTRPNNNTR
345
9
28
44
8668
|
|
ENV
ASITLTVQA
619
9
28
44
8669
|
|
ENV
VSFEPIPIIIY
253
10
28
44
8670
|
|
ENV
STVQCTIIGIK
289
10
28
44
8671
|
|
ENV
AASITLTVQA
618
10
28
44
8672
|
|
ENV
ASITLTVQAR
619
10
28
44
8673
|
|
ENV
KVSFEPIPIHY
252
11
28
44
8674
|
|
ENV
YCAPAGFAILK
263
11
28
44
8675
|
|
ENV
VSTVQCTHGIK
288
11
28
44
8676
|
|
ENV
GAASITLTVQA
617
11
28
44
8677
|
|
ENV
AASITLTVQAR
618
11
28
44
8678
|
|
ENV
LIGLRIVF
787
8
29
45
8679
|
|
ENV
VSFEPIPIH
253
9
29
45
8680
|
|
ENV
GLIGLRIVF
786
9
29
45
8681
|
|
ENV
ITQACPKVSF
245
10
29
45
8682
|
|
ENV
KVSFEPIPIII
252
10
29
45
8683
|
|
ENV
CAPAGFAILK
264
30
29
45
8684
|
|
ENV
GGLIGLRIVF
785
30
29
45
8685
|
|
ENV
RSELYKYKVV
558
11
29
45
8686
|
|
ENV
IIGDIRQA
377
8
30
49
8687
|
|
ENV
WASLWNWF
761
8
30
47
8688
|
|
ENV
AVLSIVNR
795
8
31
48
8689
|
|
ENV
AVAEGTDR
928
8
31
48
8690
|
|
ENV
VTENFNMWK
102
9
31
48
8691
|
|
ENV
SPEPIPIIIY
254
9
31
48
8692
|
|
ENV
FAVLSIVNR
794
9
31
48
8693
|
|
ENV
SLCLFSYIIR
859
9
31
48
8694
|
|
ENV
IAVAEGTDR
927
9
31
48
0.0004
8695
|
|
ENV
NVTENFNMW
101
10
31
48
8696
|
|
ENV
AVLSIVNRVR
795
10
31
48
8697
|
|
ENV
RSLCLFSYIIR
858
10
31
48
8698
|
|
ENV
AIAVAEGTDR
926
10
31
48
8699
|
|
ENV
FAVLSIVNRVR
794
11
31
48
8700
|
|
ENV
DDLRSLCLFSY
855
11
31
48
8701
|
|
ENV
SLCLFSYIIRLR
859
11
31
48
8702
|
|
ENV
ELYKYKVVK
560
9
32
51
8703
|
|
ENV
RVVEREKR
587
8
32
50
8704
|
|
ENV
VVEREKRA
588
8
32
50
8705
|
|
ENV
SITLTVQA
620
8
32
50
8706
|
|
ENV
ITLTVQAR
623
8
32
50
8707
|
|
ENV
SLCLFSYH
859
8
32
50
8708
|
|
ENV
RVVEREKRA
587
9
32
50
8709
|
|
ENV
SITLTVQAR
620
9
32
50
8710
|
|
ENV
RSLCLFSYII
858
9
32
50
8711
|
|
ENV
DLRSLCLFSYH
856
11
32
50
8712
|
|
ENV
SFEPIPIII
254
8
33
52
8713
|
|
ENV
RVLAVERY
665
8
33
52
8714
|
|
ENV
QARVLAVER
663
9
33
52
0.0009
8715
|
|
ENV
DDLRSLCLF
855
9
33
52
8716
|
|
ENV
QARVLAVERY
663
10
33
52
8717
|
|
ENV
WDDLRSLCLF
854
10
33
52
8718
|
|
ENV
QLQARVLAVE
661
11
33
52
8719
|
|
ENV
IMIVGGLIGLR
781
11
34
54
8720
|
|
ENV
GVPVWKEA
52
8
34
53
8721
|
|
ENV
YGVPVWKEA
51
9
34
53
8722
|
|
ENV
RIRQGLERA
953
9
34
53
8723
|
|
ENV
LLQLTVWGIK
651
10
34
53
0.0055
8724
|
|
ENV
IILLQLTVWGI
650
11
34
53
8725
|
|
ENV
LSIVNRVRQGY
797
11
34
53
8726
|
|
ENV
NLWVTVYY
44
8
35
56
8727
|
|
ENV
NCGGEFFY
439
8
35
55
8728
|
|
ENV
RSLCLFSY
858
8
35
55
8729
|
|
ENV
EVHNVWATH
77
9
35
55
8730
|
|
ENV
SFNCGGEFF
437
9
35
55
8731
|
|
ENV
NITGLLLTR
519
9
35
55
0.0004
8732
|
|
ENV
EVIINVWATIIA
77
10
35
55
8733
|
|
ENV
IISFNCGGEFF
434
10
35
55
8734
|
|
ENV
SFNCGGEFFY
437
10
35
55
8735
|
|
ENV
DLRSLCLFSY
856
10
35
55
8736
|
|
ENV
IISFNCGGEFFY
434
11
35
55
8737
|
|
ENV
SFNCGGEF
437
8
36
56
8738
|
|
ENV
IISFNCGGEF
434
9
36
56
8739
|
|
ENV
PIPIIIYCAPA
258
10
36
56
8740
|
|
ENV
GGGDMRDNW
549
10
36
56
8741
|
|
ENV
MIVGGLIGLR
782
10
36
56
8742
|
|
ENV
SIVNRVRQGY
798
10
36
56
0.0008
8743
|
|
ENV
PGGGDMRDN
548
11
36
56
8744
|
|
ENV
PIIIYCAPA
260
8
37
58
8745
|
|
ENV
ITGLLLTR
520
8
37
58
8746
|
|
ENV
DMRDNWRSEL
552
11
37
58
8747
|
|
ENV
PAGFAILK
266
8
38
59
8748
|
|
ENV
LSIVNRVR
797
8
38
59
8749
|
|
ENV
DLRSLCLF
856
8
38
59
8750
|
|
ENV
VLSIVNRVR
796
9
38
59
8751
|
|
ENV
IVNRVRQGY
799
9
38
59
8752
|
|
ENV
IISLWDQSLK
121
10
38
59
0.0410
8753
|
|
ENV
DIISLWDQSLK
120
11
38
59
8754
|
|
ENV
GDMRDNWR
551
8
39
61
8755
|
|
ENV
GGDMRDNWR
550
9
39
61
8756
|
|
ENV
QACPKVSF
248
8
40
63
8757
|
|
ENV
PIPIHYCA
258
8
40
63
8758
|
|
ENV
RDNWRSELY
554
9
40
63
0.0003
8759
|
|
ENV
RDNWRSELYK
554
10
40
63
0.0008
8760
|
|
ENV
TLFCASDAKA
64
11
40
63
8761
|
|
ENV
RDNWRSELYK
554
11
40
63
8762
|
|
ENV
GIKQLQARVLA
658
11
40
63
8763
|
|
ENV
QLQARVLA
661
8
41
64
8764
|
|
ENV
TVYYGVPVWK
48
10
41
64
3.8000
8765
|
|
ENV
VTVYYGVPVW
47
11
41
64
0.8600
8766
|
|
ENV
CASDAKAY
67
8
42
66
8767
|
|
ENV
LCLFSYIIR
860
8
42
66
8768
|
|
ENV
FCASDAKAY
66
9
42
66
8769
|
|
ENV
IVGGLIGLR
783
9
42
66
8770
|
|
ENV
CLFSYIIRLR
861
9
42
66
8771
|
|
ENV
LFCASDAKAY
65
10
42
66
0.0004
8772
|
|
ENV
GAAGSTMGAA
610
10
42
66
8773
|
|
ENV
LCLFSYHRLR
860
10
42
66
8774
|
|
ENV
LGAAGSTMGA
609
11
42
66
8775
|
|
ENV
VGGLIGLR
784
8
43
67
8776
|
|
ENV
QLTVWGIK
653
8
44
69
8777
|
|
ENV
LFSYHRLR
862
8
44
69
8778
|
|
ENV
RIRQGLER
953
8
44
69
8779
|
|
ENV
TTLFCASDAK
61
11
44
69
8780
|
|
ENV
AAGSTMGAA
611
9
45
70
8781
|
|
ENV
TLFCASDAKA
64
10
46
72
8782
|
|
ENV
SLWDQSLK
123
8
47
75
8783
|
|
ENV
ISLWDQSLK
122
9
47
73
0.0048
8784
|
|
ENV
WDQSLKPCVK
125
10
47
73
8785
|
|
ENV
RVRQGYSPLSF
802
11
47
73
8786
|
|
ENV
QSLKPCVK
127
8
48
75
8787
|
|
ENV
FLGFLGAA
604
8
48
75
8788
|
|
ENV
QGYSPLSF
805
8
48
75
8789
|
|
ENV
TVWGIKQLQA
655
11
48
75
8790
|
|
ENV
GIKQLQAR
658
8
49
77
8791
|
|
ENV
WGIKQLQAR
657
9
49
77
0.0004
8792
|
|
ENV
TVWGIKQLQA
655
10
49
77
8793
|
|
ENV
LTVWGIKQLQ
654
11
49
77
8794
|
|
ENV
FCASDAKA
66
8
50
78
8795
|
|
ENV
AGSTMGAA
612
8
50
78
8796
|
|
ENV
WLWYIKIF
773
8
50
78
8797
|
|
ENV
LFCASDAKA
65
9
50
78
8798
|
|
ENV
LGIWGCSGK
679
9
50
78
0.0097
8799
|
|
ENV
TTLFCASDAK
61
10
50
78
0.0920
8800
|
|
ENV
LLGIWGCSGK
678
10
50
78
0.1200
8801
|
|
ENV
NLLRAIEAQQII
640
11
50
78
8802
|
|
ENV
QLLGIWGCSG
677
11
50
78
8803
|
|
ENV
VSTVQCTII
288
8
51
80
8804
|
|
ENV
NLLRAIEA
640
8
51
80
8805
|
|
ENV
RAIEAQQH
643
8
51
80
8806
|
|
ENV
WGIKQLQA
657
8
51
80
8807
|
|
ENV
NVSTVQCTII
287
9
51
80
8808
|
|
ENV
LLRAIEAQQH
641
10
51
80
8809
|
|
ENV
GIWGCSGK
680
8
52
81
8810
|
|
ENV
TTLFCASDA
61
9
52
81
8811
|
|
ENV
TLFCASDAK
64
9
52
81
0.0930
8812
|
|
ENV
TLFCASDA
64
8
54
84
8813
|
|
ENV
RSELYKYK
558
8
54
84
8814
|
|
ENV
LLLNGSLA
306
8
55
86
8815
|
|
ENV
QLLLNGSLA
305
9
55
86
8816
|
|
ENV
GAAGSTMGA
610
9
55
86
8817
|
|
ENV
LGAAGSTMGA
609
10
55
86
8818
|
|
ENV
STQLLLNGSLA
303
11
55
86
8819
|
|
ENV
FLGAAGSTMG
608
11
55
86
8820
|
|
ENV
LFCASDAK
65
8
57
89
8821
|
|
ENV
AAGSTMGA
611
8
58
91
8822
|
|
GAG
EDTSARQA
133
8
01
33
8823
|
|
GAG
AAAIMMQK
405
8
01
25
8824
|
|
GAG
SATIMMQR
405
8
01
25
8825
|
|
GAG
TAPPPESF
S08
8
01
33
8826
|
|
GAG
KDKDKELY
535
8
01
25
8827
|
|
GAG
ETIDKDLY
537
8
01
25
8828
|
|
GAG
NSATIMMQR
404
9
01
33
8829
|
|
GAG
PTAPPPESF
507
9
01
33
8830
|
|
GAG
TAPPPESFR
508
9
01
33
8831
|
|
GAG
NGKQANFLGK
461
10
01
25
8832
|
|
GAG
NGRQANFLGK
461
10
01
25
8833
|
|
GAG
PTAPPPESFR
507
10
01
33
8834
|
|
GAG
TAPPPESFRF
508
10
01
33
8835
|
|
GAG
TIDKDLYPLA
538
10
01
25
8836
|
|
GAG
AAAIMMQKSN
405
11
01
25
8837
|
|
GAG
SATIMMQRGN
405
11
01
25
8838
|
|
GAG
NGKQANFLGK
461
11
01
25
8839
|
|
GAG
NGRQANFLGK
461
11
01
25
8840
|
|
GAG
PTAPPPESFRF
507
11
01
33
8841
|
|
GAG
KDKDKELYPL
535
11
01
25
8842
|
|
GAG
ETIDKDLYPLA
537
11
01
25
8843
|
|
GAG
PAAADKEK
123
8
01
50
8844
|
|
GAG
ASAQQDLK
392
8
01
50
8845
|
|
GAG
ATAQQDLK
392
8
01
50
8846
|
|
GAG
PAEPTAPPA
492
9
01
50
8847
|
|
GAG
AADKGVSQNY
130
10
01
50
8848
|
|
GAG
SAQQDLKGGY
393
10
01
50
8849
|
|
GAG
TAQQDLKGGY
393
10
01
50
8850
|
|
GAG
GTRPGNYVQK
480
10
01
50
8851
|
|
GAG
GTRPGNYVQR
480
10
01
50
8852
|
|
GAG
ITSLPKQEQK
526
10
01
50
8853
|
|
GAG
PAAADKEKDS
123
11
01
50
8854
|
|
GAG
GANSIPVGDIY
276
11
01
50
8855
|
|
GAG
ASAQQDLKGG
392
11
01
50
8856
|
|
GAG
ATAQQDLKGG
392
11
01
50
8857
|
|
GAG
EITSLPKQEQK
525
11
01
50
8858
|
|
GAG
YTAVFMQR
405
8
02
50
8859
|
|
GAG
TAPPAESF
508
8
02
67
8860
|
|
GAG
PTAPPAESF
507
9
02
67
8861
|
|
GAG
TAPPAESFR
508
9
02
67
8862
|
|
GAG
PTAPPAESFR
507
10
02
67
8863
|
|
GAG
TAPPAESFRF
508
10
02
67
8864
|
|
GAG
PTAPPAESFRF
507
11
02
67
8865
|
|
GAG
EGRQANFLGK
462
10
02
100
8866
|
|
GAG
AADKGKVSQN
129
11
02
18
8867
|
|
GAG
EADGKVSQNY
129
10
04
36
8868
|
|
GAG
AAAIMMQK
400
8
04
19
8869
|
|
GAG
AAIMMQKSNF
406
10
06
15
8870
|
|
GAG
AAIMMQKSNF
406
11
06
15
8871
|
|
GAG
KTVKCFNCGK
421
10
08
16
8872
|
|
GAG
NIMMQRGNF
407
9
10
17
8873
|
|
GAG
GARASILR
2
8
10
16
8874
|
|
GAG
PGNFPQSR
483
8
10
16
8875
|
|
GAG
MGARASILR
1
9
10
16
8876
|
|
GAG
KIWPSSKGR
472
9
10
16
8877
|
|
GAG
TGNSSQVSQN
139
11
10
16
8878
|
|
GAG
NFLGKIWPSSK
468
11
10
16
8879
|
|
GAG
NFLQNRPEPTA
485
11
10
16
8880
|
|
GAG
PVAPGQMR
243
8
10
16
8881
|
|
GAG
MMQKSNFK
409
8
10
16
8882
|
|
GAG
MMQRGNFK
409
8
10
16
8883
|
|
GAG
KLDKWEKIR
12
9
10
16
8884
|
|
GAG
GGKKKYKLK
24
9
10
16
0.0001
8885
|
|
GAG
RDTKEALDK
97
9
10
16
8886
|
|
GAG
ALSPRTLNA
167
9
10
16
8887
|
|
GAG
IMMQKSNFK
408
9
10
16
8888
|
|
GAG
LGKIWPSSK
470
9
10
16
8889
|
|
GAG
PGGKKKYKLK
23
10
10
16
8890
|
|
GAG
GGKKKYKLKII
24
10
10
16
8891
|
|
GAG
QALSPRTLNA
166
10
10
16
8892
|
|
GAG
AGPVAPGQMR
241
10
10
16
8893
|
|
GAG
GASLEEMMTA
364
10
10
16
8894
|
|
GAG
FLGKIWPSSK
469
10
10
16
8895
|
|
GAG
FLQNRPEPTA
486
10
10
16
8896
|
|
GAG
TAPPAESFGF
496
10
10
16
8897
|
|
GAG
KLDKWEKIRL
12
11
10
16
8898
|
|
GAG
PGGKKKYKLK
23
11
10
16
8899
|
|
GAG
LGKIWPSSKGR
470
11
10
16
8900
|
|
GAG
PTAPPAESFGF
495
11
10
16
8901
|
|
GAG
ATIMMQRGNF
406
10
11
28
8902
|
|
GAG
ATIMMQRGNF
406
11
11
28
8903
|
|
GAG
PSQKQEPIDK
528
10
11
18
8904
|
|
GAG
SSKGRPGNF
476
9
11
18
8905
|
|
GAG
TTSTLQEQIA
260
10
11
17
8906
|
|
GAG
DVKDTKEA
95
8
11
17
8907
|
|
GAG
PIPVGDIY
279
8
11
17
8908
|
|
GAG
SLEEMMTA
366
8
11
17
8909
|
|
GAG
MSQVTNSA
391
8
11
17
8910
|
|
GAG
IMMQKSNF
408
8
11
17
8911
|
|
GAG
IDVKDTKEA
94
9
11
17
8912
|
|
GAG
ASLEEMMTA
365
9
11
17
8913
|
|
GAG
AMSQVTNSA
390
9
11
17
8914
|
|
GAG
TIKCFNCGK
422
9
11
17
8915
|
|
GAG
TVKCFNCGK
422
9
11
17
8916
|
|
GAG
EAMSQVTNSA
389
10
11
17
8917
|
|
GAG
PSSKGRPGNF
475
10
11
17
8918
|
|
GAG
GTTSTLQEQIA
259
11
11
17
8919
|
|
GAG
TIMMQRGNFR
407
10
12
21
8920
|
|
GAG
QTGSEELR
71
8
12
19
8921
|
|
GAG
KSKKKAQQAA
112
10
12
19
8922
|
|
GAG
KSKKKAQQAA
112
11
12
19
8923
|
|
GAG
PGGKKKYK
23
8
12
19
8924
|
|
GAG
TLYCVHQK
86
8
12
19
8925
|
|
GAG
DTKEALEK
98
8
12
19
8926
|
|
GAG
MLNIVGGII
208
8
12
19
8927
|
|
GAG
NIVGGIIQA
210
8
12
19
8928
|
|
GAG
IVGGIIQAA
211
8
12
19
8929
|
|
GAG
STLQEQIA
262
8
12
19
8930
|
|
GAG
PTSILDIR
303
8
12
19
8931
|
|
GAG
LTSLRSLF
549
8
12
19
8932
|
|
GAG
GSEELRSLY
73
9
12
19
8933
|
|
GAG
ATLYCYIIQK
85
9
12
19
8934
|
|
GAG
KDTKEALEK
97
9
12
19
8935
|
|
GAG
MMLNIVGGH
207
9
12
19
8936
|
|
GAG
NIVGGIIQAA
210
9
12
19
8937
|
|
GAG
TSTLQEQIA
261
9
12
19
8938
|
|
GAG
PLTSLKSLF
548
9
12
19
8939
|
|
GAG
PLTSLRSLF
548
9
12
19
8940
|
|
GAG
TGSEELRSLY
72
10
12
19
8941
|
|
GAG
VATLYCVHQK
84
10
12
19
8942
|
|
GAG
NAQGQMVHQA
158
10
12
19
8943
|
|
GAG
NMMLNIVGGII
206
10
12
19
8944
|
|
GAG
MLNIVGGIIQA
208
10
12
19
8945
|
|
GAG
YSPTSILDIR
301
10
12
19
8946
|
|
GAG
RAEQASQEVK
329
10
12
19
8947
|
|
GAG
RLRPGGKKKY
20
11
12
19
8948
|
|
GAG
TVATLYCVHQ
83
11
12
19
8949
|
|
GAG
MMLNIVGGIIQ
207
11
12
19
8950
|
|
GAG
MLNIVGGIIQA
208
11
12
19
8951
|
|
GAG
TSILDIRQGPK
304
11
12
19
8952
|
|
GAG
TIMMQRGNF
407
9
13
22
8953
|
|
GAG
PGNFLQNR
483
8
13
21
8954
|
|
GAG
IARNCRAPR
434
9
13
21
8955
|
|
GAG
KIWPSNKGR
472
9
13
21
8956
|
|
GAG
NCGKEGHIAR
427
10
13
21
8957
|
|
GAG
IARNCRAPRK
434
10
13
21
8958
|
|
GAG
IARNCRAPRKK
434
11
13
21
8959
|
|
GAG
NFLGKIWPSNK
468
11
13
21
8960
|
|
GAG
KGRPGNFLQN
478
11
13
21
8961
|
|
GAG
KLKIIIVWA
31
8
13
20
8962
|
|
GAG
RIEVKDTK
93
8
13
20
8963
|
|
GAG
HIARNCRA
433
8
13
20
8964
|
|
GAG
LTSLKSLF
549
8
13
20
8965
|
|
GAG
IVKCFNCGK
422
9
13
20
8966
|
|
GAG
CGKEGIIIAR
428
9
13
20
8967
|
|
GAG
EGHIARNCR
431
9
13
20
8968
|
|
GAG
LGKIWPSNK
470
9
13
20
8969
|
|
GAG
KLKIIIVWASR
31
10
13
20
8970
|
|
GAG
RIEVKDTKEA
93
10
13
20
8971
|
|
GAG
TILRALGPGA
356
10
13
20
8972
|
|
GAG
EGHIARNCRA
431
10
13
20
8973
|
|
GAG
HIARNCRAPR
433
10
13
20
8974
|
|
GAG
FLGKIWPSNK
469
10
13
20
8975
|
|
GAG
EVKDTKEALD
95
11
13
20
8976
|
|
GAG
FSPEVIPMFTA
185
11
13
20
8977
|
|
GAG
AAEWDRVHPV
230
11
13
20
8978
|
|
GAG
KTILRALGPGA
355
11
13
20
8979
|
|
GAG
HIARNCRAPRK
433
11
13
20
8980
|
|
GAG
LGKIWPSNKG
470
11
13
20
8981
|
|
GAG
NSSQVSQNY
144
9
14
31
8982
|
|
GAG
KSKKKAQQA
112
9
14
22
8983
|
|
GAG
NCGKEGIIIAK
427
10
14
22
8984
|
|
GAG
IAKNCRAPRKK
434
11
14
22
8985
|
|
GAG
EVIPMFTA
188
8
14
22
8986
|
|
GAG
RGNFRNQRK
412
9
14
22
8987
|
|
GAG
CGKEGIIIAK
428
9
14
22
8988
|
|
GAG
EGIIIAKNCR
431
9
14
22
8989
|
|
GAG
EGIIIAKNCRA
431
10
14
22
8990
|
|
GAG
PSNKGRPGNF
475
10
14
22
8991
|
|
GAG
TAPPEESFRF
496
10
14
22
8992
|
|
GAG
TVATLYCVIIQ
83
11
I4
22
8993
|
|
GAG
IVQNAQGQMV
155
11
14
22
8994
|
|
GAG
PTAPPEESFRF
495
11
14
22
8995
|
|
GAG
SSQVSQNY
145
8
15
31
8996
|
|
GAG
VSQNYPIVQNA
149
11
15
26
8997
|
|
GAG
RSLYNTVATL
78
11
15
24
8998
|
|
GAG
TLYCVIIQR
86
8
15
23
8999
|
|
GAG
FTALSEGA
193
8
15
23
9000
|
|
GAG
AAEWDRVII
230
8
15
23
9001
|
|
GAG
WDRVIIPVII
233
8
15
23
9002
|
|
GAG
RGNFRNQR
412
8
15
23
9003
|
|
GAG
TAPPEESF
496
8
15
23
9004
|
|
GAG
LASLKSLF
549
8
15
23
9005
|
|
GAG
VLSGGKLDA
7
9
15
23
9006
|
|
GAG
LFNTVATLY
80
9
15
23
9007
|
|
GAG
ATLYCVIIQR
85
9
15
23
0.0150
9008
|
|
GAG
MFTALSEGA
192
9
15
23
9009
|
|
GAG
EAAEWDRVII
229
9
15
23
9010
|
|
GAG
WDRVIIPVIIA
233
9
15
23
9011
|
|
GAG
PTAPPEESF
495
9
15
23
9012
|
|
GAG
TAPPEESFR
496
9
15
23
9013
|
|
GAG
PLASLKSLF
548
9
15
23
9014
|
|
GAG
SVLSGGKLDA
6
10
15
23
9015
|
|
GAG
SGGKLDAWEK
9
10
15
23
9016
|
|
GAG
ELRSLYNTVA
76
10
15
23
9017
|
|
GAG
SLFNTVATLY
79
10
15
23
9018
|
|
GAG
VATLYCVHQR
84
10
15
23
9019
|
|
GAG
KIEELQNKSK
105
10
15
23
9020
|
|
GAG
PMFTALSEGA
191
10
15
23
9021
|
|
GAG
RAEQATQDVK
329
10
15
23
9022
|
|
GAG
PTAPPEESFR
495
10
15
23
9023
|
|
GAG
ASVLSGGKLD
5
11
15
23
9024
|
|
GAG
LSGGKLDAWE
8
11
15
23
9025
|
|
GAG
PGLLETSEGCR
50
11
15
23
9026
|
|
GAG
KIEEEQNKSKK
105
11
15
23
9027
|
|
GAG
RLIIPVHAGPIA
235
11
15
23
9028
|
|
GAG
MMQRGNFRN
409
11
15
23
9029
|
|
GAG
IAKNCRAPRK
434
10
16
25
9030
|
|
GAG
LSGGKLDA
8
8
16
25
9031
|
|
GAG
LDAWEKIR
13
8
16
25
9032
|
|
GAG
NAQGQMVII
158
8
16
25
9033
|
|
GAG
PVSILDIK
303
8
16
25
9034
|
|
GAG
ILKALGPA
357
8
16
25
9035
|
|
GAG
KLDAWEKIR
12
9
16
25
9036
|
|
GAG
GGKKKYRLK
24
9
16
25
9037
|
|
GAG
TILKALGPA
356
9
16
25
9038
|
|
GAG
ILKALGPAA
357
9
16
25
0.0003
9039
|
|
GAG
VLAEAMSQA
386
9
16
25
9040
|
|
GAG
LDAWEKIRLR
13
10
16
25
9041
|
|
GAG
PGGKKKYRLK
23
10
16
25
9042
|
|
GAG
GGKKKYRLKII
24
10
16
25
9043
|
|
GAG
GLLETSEGCR
51
10
16
25
9044
|
|
GAG
YSPVSILDIK
301
10
16
25
9045
|
|
GAG
KTILKALGPA
355
10
16
25
0.0045
9046
|
|
GAG
TILKALGPAA
356
10
16
25
9047
|
|
GAG
AATLEEMMTA
364
10
16
25
9048
|
|
GAG
RVLAEAMSQA
385
10
16
25
9049
|
|
GAG
GGKLDAWEKI
10
11
16
25
9050
|
|
GAG
KLDAWEKIRL
12
11
16
25
9051
|
|
GAG
PGGKKKYRLK
23
11
16
25
9052
|
|
GAG
VSILDIKQGPK
304
11
16
25
9053
|
|
GAG
KTILKALGPAA
355
11
16
25
9054
|
|
GAG
PAATLEEMMT
363
11
16
25
9055
|
|
GAG
HIAKNCRAPRK
433
11
16
25
9056
|
|
GAG
LAEAMSQA
387
8
17
27
9057
|
|
GAG
RLKHLVWA
31
8
17
27
9058
|
|
GAG
LSPRTLNA
168
8
17
27
9059
|
|
GAG
PIPPGQMR
243
8
17
27
9060
|
|
GAG
GGKLDAWEK
10
9
17
27
9061
|
|
GAG
DAWEKIRLR
14
9
17
27
9062
|
|
GAG
LLETSEGCR
52
9
17
27
9063
|
|
GAG
RLKHLVWASR
31
10
17
27
9064
|
|
GAG
LDKIEEEQNK
103
10
17
27
9065
|
|
GAG
AGPIPPGQMR
241
10
17
27
9066
|
|
GAG
ALDKIEEEQNK
102
11
17
27
9067
|
|
GAG
LSPRTLNAWV
168
11
17
27
9068
|
|
GAG
HAGPIPPGQMR
240
11
17
27
9069
|
|
GAG
PIPPGQMREPR
243
11
17
27
9070
|
|
GAG
PGATLEEMMT
363
11
17
27
9071
|
|
GAG
RSLYNTVA
78
8
18
29
9072
|
|
GAG
IAKNCRAPR
434
9
18
29
0.0009
9073
|
|
GAG
LDKWEKIR
13
8
18
28
9074
|
|
GAG
PVGDIYKR
281
8
18
28
9075
|
|
GAG
PDCKTILR
352
8
18
28
9076
|
|
GAG
DCKTILRA
353
8
18
28
9077
|
|
GAG
IIIAKNCRA
433
8
18
28
9078
|
|
GAG
PDCKTILRA
352
9
18
28
9079
|
|
GAG
ILRALGPGA
357
9
18
28
9080
|
|
GAG
LDKWEKIRLR
13
10
18
28
9081
|
|
GAG
SILDIKQGPK
305
10
18
28
9082
|
|
GAG
IIIAKNCRAPR
433
10
18
28
9083
|
|
GAG
IIAGPIAPGQM
240
11
18
28
9084
|
|
GAG
NANPDCKTILR
349
11
18
28
9085
|
|
GAG
LARNCRAPRK
434
11
19
30
9086
|
|
GAG
PVIIAGPIA
238
8
19
30
9087
|
|
GAG
PIAPGQMR
243
8
19
30
9088
|
|
GAG
LDIKQGPK
307
8
19
30
9089
|
|
GAG
ILDIKQGPK
306
9
19
30
9090
|
|
GAG
PSIIKARVLA
380
9
19
30
9091
|
|
GAG
AGPIAPGQMR
241
10
19
30
9092
|
|
GAG
IAPGQMREPR
244
10
19
30
9093
|
|
GAG
DIKQGPKEPF
308
10
19
30
9094
|
|
GAG
RLRPGGKKKY
20
11
19
30
9095
|
|
GAG
IVWASRELERF
35
11
19
30
9096
|
|
GAG
PIAPGQMREPR
243
11
19
30
9097
|
|
GAG
LDIKQGPKEPF
307
11
19
30
9098
|
|
GAG
DIKQGPKEPFR
308
11
19
30
9099
|
|
GAG
GGPSIIKARVL
378
11
19
30
9100
|
|
GAG
PSIIKARVLAE
380
11
19
30
9101
|
|
GAG
LARNCRAPR
434
9
20
32
9102
|
|
GAG
LARNCRAPRK
434
10
20
32
9103
|
|
GAG
PGGKKKYR
23
8
20
31
9104
|
|
GAG
TAPPAESF
496
8
20
31
9105
|
|
GAG
IMMQRGNFR
408
9
20
31
9106
|
|
GAG
PTAPPAESF
495
9
20
31
9107
|
|
GAG
IVWASRELER
35
10
20
31
0.0099
9108
|
|
GAG
HLARNCRAPR
433
10
20
31
9109
|
|
GAG
HIVWASRELER
34
11
20
31
9110
|
|
GAG
IILARNCRAPR
433
11
20
31
9111
|
|
GAG
IILARNCRA
433
8
21
33
9112
|
|
GAG
EGIILARNCR
431
9
21
33
9113
|
|
GAG
NLQGQMVHQA
158
10
21
33
9114
|
|
GAG
EGHLARNCRA
431
10
21
33
9115
|
|
GAG
QSRPEPTAPPA
488
11
21
33
9116
|
|
GAG
KIWPSIIKGR
472
9
22
35
0.0770
9117
|
|
GAG
EVKDTKEA
95
8
22
34
9118
|
|
GAG
ETINEEAA
224
8
22
34
9119
|
|
GAG
DTLLVQNA
343
8
22
34
9120
|
|
GAG
GGPSIIKAR
378
8
22
34
9121
|
|
GAG
TDTLLVQNA
342
9
22
34
9122
|
|
GAG
VGGPSHKAR
377
9
22
34
9123
|
|
GAG
SLYNTYATLY
79
10
22
34
9124
|
|
GAG
MLKETINEEA
221
10
22
34
9125
|
|
GAG
MTDTLLVQNA
341
10
22
34
9126
|
|
GAG
GVGGPSHKAR
376
10
22
34
9127
|
|
GAG
QMLKETINEEA
220
11
22
34
9128
|
|
GAG
MLKETINEEAA
221
11
22
34
9129
|
|
GAG
WMTDTLLVQ
340
11
22
34
9130
|
|
GAG
QGVGGPSHKA
375
11
22
34
9131
|
|
GAG
LGKIWPSIIKG
470
11
22
34
9132
|
|
GAG
NFLGKIWPSHK
468
11
23
37
9133
|
|
GAG
KIEEEQNK
105
8
23
36
9134
|
|
GAG
QGVGGPSII
375
8
23
36
9135
|
|
GAG
GVGGPSIIK
376
8
23
36
9136
|
|
GAG
VGGPSIIKA
377
8
23
36
9137
|
|
GAG
MMQRGNFR
409
8
23
36
9138
|
|
GAG
QGVGGPSIIK
375
9
23
36
9139
|
|
GAG
GVGGPSIIKA
376
9
23
36
9140
|
|
GAG
LGKIWPSIIK
470
9
23
36
9141
|
|
GAG
ACQGVGGPSII
373
10
23
36
9142
|
|
GAG
QGVGGPSIIKA
375
10
23
36
9143
|
|
GAG
FLGKIWPSIIK
469
10
23
36
0.0200
9144
|
|
GAG
PSIIKGRPGNF
475
10
23
36
9145
|
|
GAG
TACQGVGGPS
372
11
23
36
9146
|
|
GAG
ACQGVGGPSII
373
11
23
36
9147
|
|
GAG
NCGKEGIILAR
427
10
24
38
9148
|
|
GAG
KVIEEKAF
178
8
24
38
9149
|
|
GAG
CGKEGIILAR
428
9
24
38
9150
|
|
GAG
WVKVIEEKAF
176
10
24
38
9151
|
|
GAG
YSPVSILDIR
301
10
24
38
9152
|
|
GAG
NFLGKIWPSII
468
10
25
40
9153
|
|
GAG
PVSILDIR
303
8
25
39
9154
|
|
GAG
LGKIWIPSII
470
8
25
39
9155
|
|
GAG
KDTKEALDK
97
9
25
39
9156
|
|
GAG
WVKVIEEKA
176
9
25
39
9157
|
|
GAG
FLGKIWPSII
469
9
25
39
9158
|
|
GAG
LYWASRELER
35
11
25
39
9159
|
|
GAG
NAWVKVIEEK
174
11
25
39
9160
|
|
GAG
VSILDIRQGPK
304
11
25
39
9161
|
|
GAG
LVWASRELER
35
10
26
41
9162
|
|
GAG
HLVWASRELE
34
11
26
41
9163
|
|
GAG
CFNCGKEGIIIA
425
11
26
41
9164
|
|
GAG
NCGKEGIIIA
427
9
27
43
9165
|
|
GAG
NCGKEGIILA
427
9
27
43
9166
|
|
GAG
RFFKTLRA
323
8
27
42
9167
|
|
GAG
IMMQRGNF
408
8
27
42
9168
|
|
GAG
CGKEGHIA
428
8
27
42
9169
|
|
GAG
CGKEGIILA
428
8
27
42
9170
|
|
GAG
MVIIQAISPR
163
9
27
42
0.1800
9171
|
|
GAG
VDRFFKTLR
321
9
27
42
9172
|
|
GAG
QMVIIQAISPR
162
10
27
42
0.0260
9173
|
|
GAG
YVDRFFKTLR
320
10
27
42
9174
|
|
GAG
VDRFFKTLRA
321
10
27
42
9175
|
|
GAG
FFKTLRAEQA
324
10
27
42
9176
|
|
GAG
RAEQATQEVK
329
10
27
42
9177
|
|
GAG
NAWVKVVEEK
174
11
27
42
9178
|
|
GAG
YVDRFFKTLR
320
11
27
42
9179
|
|
GAG
RFFKTLRAEQ
323
11
27
42
9180
|
|
GAG
RFYKTLRAEQ
323
11
27
42
9181
|
|
GAG
NANPDCKTILK
349
11
27
42
9182
|
|
GAG
CFNCGKEGHL
425
11
27
42
9183
|
|
GAG
KGRPGNFLQS
478
11
28
44
9184
|
|
GAG
NFLQSRPEPTA
485
11
28
44
9185
|
|
GAG
KVVEEKAF
178
8
28
44
9186
|
|
GAG
RFYKTLRA
323
8
28
44
9187
|
|
GAG
PDCKTILK
352
8
28
44
9188
|
|
GAG
DCKTILKA
353
8
28
44
9189
|
|
GAG
WVKVVEEKA
176
9
28
44
9190
|
|
GAG
VDRFYKTLR
321
9
28
44
9191
|
|
GAG
PDCKTILKA
352
9
28
44
9192
|
|
GAG
WVKVVEEKAF
176
10
28
44
9193
|
|
GAG
PFRDYVDRFY
316
10
28
44
9194
|
|
GAG
YVDRFYKTLR
320
10
28
44
0.0003
9195
|
|
GAG
VDRFYKTLRA
321
10
28
44
9196
|
|
GAG
GATLEEMMTA
364
10
28
44
9197
|
|
GAG
FLQSRPEPTA
486
10
28
44
0.0005
9198
|
|
GAG
PFRDYVDRFY
316
11
28
44
9199
|
|
GAG
YVDRFYKTLR
320
11
28
44
9200
|
|
GAG
GARASVLSGG
2
11
29
46
9201
|
|
GAG
ASVLSGGK
5
8
29
45
9202
|
|
GAG
NLQGQMVII
158
8
29
45
9203
|
|
GAG
WVKVIEEK
176
8
29
45
9204
|
|
GAG
WDRLHPVH
233
8
29
45
9205
|
|
GAG
RDYVDRFY
318
8
29
45
9206
|
|
GAG
RASVLSGGK
4
9
29
45
9207
|
|
GAG
AISPRTLNA
167
9
29
45
0.0050
9208
|
|
GAG
WDRLHPVHA
233
9
29
45
9209
|
|
GAG
RDYVDRFYK
318
9
29
45
0.0007
9210
|
|
GAG
QAISPRTLNA
166
10
29
45
9211
|
|
GAG
NAWVKVIEEK
174
10
29
45
9212
|
|
GAG
IVQNLQGQMV
155
11
29
45
9213
|
|
GAG
AAEWDRLHPV
230
11
29
45
9214
|
|
GAG
PGNFLQSR
483
8
30
48
9215
|
|
GAG
NAWVKVVEEK
174
10
30
47
0.0004
9216
|
|
GAG
KIRLRPGGKKK
18
11
30
47
9217
|
|
GAG
WVKVVEEK
176
8
31
48
0.0003
9218
|
|
GAG
MLKDTINEEA
221
10
32
50
9219
|
|
GAG
QMLKDTINEEA
220
11
32
50
9220
|
|
GAG
MLKDTINEEAA
221
11
32
50
9221
|
|
GAG
KDTINEEA
223
8
33
52
9222
|
|
GAG
DTINEEAA
224
8
33
52
9223
|
|
GAG
KDTINEEAA
223
9
33
52
9224
|
|
GAG
RDYVDRFFK
318
9
33
52
9225
|
|
GAG
PFRDYVDRFF
316
11
33
52
9226
|
|
GAG
RLRPGGKKK
20
9
34
53
9227
|
|
GAG
RLRPGGKKKY
20
10
34
53
9228
|
|
GAG
PIPVGEIYKR
279
10
34
53
0.0003
9229
|
|
GAG
PIPVGEIY
279
8
35
55
9230
|
|
GAG
RDYVDRFF
318
8
35
55
9231
|
|
GAG
PIPVGEIYK
279
9
35
55
0.0002
9232
|
|
GAG
PGIIKARVLA
380
9
35
55
9233
|
|
GAG
PFRDYVDRFF
316
10
35
55
9234
|
|
GAG
WMTETLLVQN
340
11
35
55
9235
|
|
GAG
GGPGIIKARVL
378
11
35
55
9236
|
|
GAG
PGIIKARVLAE
380
11
35
55
9237
|
|
GAG
DTKEALDK
98
8
36
56
0.0003
9238
|
|
GAG
ISPRTLNA
168
8
36
56
9239
|
|
GAG
QGVGGPGII
375
8
36
56
9240
|
|
GAG
QSRPEPTA
488
8
36
56
9241
|
|
GAG
QGVGGPGIIK
375
9
36
56
0.0004
9242
|
|
GAG
MTETLLVQNA
341
10
36
56
9243
|
|
GAG
ACQGVGGPGII
373
10
36
56
9244
|
|
GAG
QGVGGPGIIKA
375
10
36
56
9245
|
|
GAG
ISPRTLNAWV
168
11
36
56
9246
|
|
GAG
TACQGVGGPG
372
11
36
56
0.0001
9247
|
|
GAG
ACQGVGGPGII
373
11
36
56
9248
|
|
GAG
QGVGCPGIIKA
375
11
36
56
9249
|
|
GAG
QGQMVIIQA
160
8
37
58
9250
|
|
GAG
ETLLVQNA
343
8
37
58
9251
|
|
GAG
GVGGPGIIK
376
8
37
58
0.0012
9252
|
|
GAG
VGGPGIIKA
377
8
37
58
9253
|
|
GAG
GGPGIIKAR
378
8
37
58
9254
|
|
GAG
GVGGPGIIKA
376
9
37
58
9255
|
|
GAG
VGGPGIIKAR
377
9
37
58
9256
|
|
GAG
GVGGPGIIKAR
376
10
37
58
0.0003
9257
|
|
GAG
AAEWDRLII
230
8
39
61
9258
|
|
GAG
EAAEWDRLII
229
9
39
61
9259
|
|
GAG
PVGEIYKR
281
8
40
63
0.0003
9260
|
|
GAG
TVATLYCVH
83
9
40
63
9261
|
|
GAG
NTVATLYCVH
82
10
40
63
9262
|
|
GAG
SILDIRQGPK
305
10
40
63
0.3100
9263
|
|
GAG
FSPEVIPMFSA
185
11
40
63
9264
|
|
GAG
DIRQGPKEPF
308
10
41
64
9265
|
|
GAG
LDIRQGPKEPF
307
11
41
64
9266
|
|
GAG
DIRQGPKEPFR
308
11
41
64
9267
|
|
GAG
VATLYCVH
84
8
42
66
9268
|
|
GAG
LDIRQGPK
307
8
42
66
9269
|
|
GAG
ILDIRQGPK
306
9
42
66
0.0420
9270
|
|
GAG
NTMLNTVGGH
206
10
42
66
9271
|
|
GAG
TMLNTVGGII
207
9
43
67
9272
|
|
GAG
TMLNTVGGHQ
207
11
43
67
9273
|
|
GAG
KGCWKCGK
444
8
44
69
9274
|
|
GAG
KIRLRPGGK
18
9
44
69
9275
|
|
GAG
ASRELERFA
38
9
44
69
9276
|
|
GAG
KIRLRPGGKK
18
10
44
69
1.9000
9277
|
|
GAG
WASRELERFA
37
10
44
69
9278
|
|
GAG
QMREPRGSDIA
248
11
44
69
9279
|
|
GAG
KGCWKCGKEG
444
11
44
69
9280
|
|
GAG
FSALSEGA
193
8
45
70
9281
|
|
GAG
PGQMREPR
246
8
45
70
9282
|
|
GAG
MFSALSEGA
192
9
45
70
9283
|
|
GAG
CGKEGIIQMK
449
9
45
70
9284
|
|
GAG
PMFSALSEGA
191
10
45
70
9285
|
|
GAG
KCGKEGHQMK
448
10
45
70
9286
|
|
GAG
ASRELERF
38
8
46
72
9287
|
|
GAG
EVIPMFSA
188
8
46
72
9288
|
|
GAG
TLEEMMTA
366
8
46
72
9289
|
|
GAG
WASRELERF
37
9
46
72
9290
|
|
GAG
ATLEEMMTA
365
9
46
72
0.0003
9291
|
|
GAG
MLNTVGGII
208
8
47
73
9292
|
|
GAG
NTVGGIIQA
210
8
47
73
9293
|
|
GAG
TVGGIIQAA
211
8
47
73
9294
|
|
GAG
NTVGGIIQAA
210
9
47
73
9295
|
|
GAG
MLNTVGGIIQA
208
10
47
73
0.0005
9296
|
|
GAG
MLNTVGGIIQA
208
11
47
73
9297
|
|
GAG
WASRELER
37
8
48
75
9298
|
|
GAG
GCWKCGKEGII
445
10
48
75
9299
|
|
GAG
RLRPGGKK
20
8
49
77
9300
|
|
GAG
QMKDCTER
455
8
49
77
9301
|
|
GAG
QMKDCTERQA
455
10
49
77
9302
|
|
GAG
EGIIQMKDCTE
452
11
49
77
9303
|
|
GAG
AFSPEVIPMF
184
10
50
78
0.0007
9304
|
|
GAG
KAFSPEVIPMF
183
11
50
78
9305
|
|
GAG
RAPRKKGCWK
439
10
51
80
9306
|
|
GAG
KDCTERQA
457
8
52
83
9307
|
|
GAG
KDCTERQANF
457
10
52
83
9308
|
|
GAG
CTERQANFLG
459
11
52
83
9309
|
|
GAG
DCTERQANF
458
9
52
81
9310
|
|
GAG
NCRAPRKK
437
8
53
84
9311
|
|
GAG
TINEEAAEWD
225
11
53
83
9312
|
|
GAG
KTLRAEQA
326
8
54
84
9313
|
|
GAG
FSPEVIPMF
185
9
54
84
9314
|
|
GAG
CTERQANF
459
8
55
87
9315
|
|
GAG
WIILGLNK
289
8
57
89
9316
|
|
GAG
KARVLAEA
383
8
57
89
9317
|
|
GAG
CFNCGKEGH
425
9
57
89
9318
|
|
GAG
IILGLNKIVR
290
10
57
89
0.0003
9319
|
|
GAG
KCFNCGKEGII
424
10
57
89
9320
|
|
GAG
WIILGLNKIVR
289
11
57
89
9321
|
|
GAG
ILGLNKIVRMY
291
11
57
89
9322
|
|
GAG
ILGLNKIVR
291
9
58
91
0.0008
9323
|
|
GAG
LGLNKIVRMY
292
10
58
91
0.0004
9324
|
|
GAG
LLVQNANPDC
345
11
58
91
9325
|
|
GAG
LGLNKIVR
292
8
59
92
9326
|
|
GAG
LVQNANPDCK
346
10
59
92
0.0002
9327
|
|
GAG
GLNKIVRMY
293
9
60
94
0.0100
9328
|
|
GAG
QAAMQMLK
216
8
61
95
9329
|
|
GAG
GGIIQAAMQM
213
11
61
95
9330
|
|
GAG
RTLNAWVK
171
8
63
98
0.0410
9331
|
|
GAG
QGPKEPFR
311
8
63
98
9332
|
|
GAG
PFRDYVDR
316
8
63
98
9333
|
|
GAG
PFRDYVDRF
316
9
63
98
9334
|
|
GAG
QGPKEPFRDY
311
10
63
98
0.0004
9335
|
|
NEF
QAEPAAAGVG
34
11
01
33
9336
|
|
NEF
RAQAEPAA
32
8
01
17
9337
|
|
NEF
RAQAEPAAA
32
9
01
17
9338
|
|
NEF
QTEPAAVGVG
32
11
01
17
9339
|
|
NEF
RAEPAADGVG
32
11
01
17
9340
|
|
NEF
RTEPAAVGVG
32
11
01
17
9341
|
|
NEF
QAEPAAEGVG
33
11
01
17
9342
|
|
NEF
QAPTAAKGVG
33
11
01
17
9343
|
|
NEF
AADGVGAVSR
42
10
09
15
9344
|
|
NEF
SSIVGWPA
8
8
09
15
9345
|
|
NEF
VGWPAIRER
11
9
10
17
9346
|
|
NEF
AAEGVGAA
42
8
10
16
9347
|
|
NEF
FDSRLAFII
310
8
10
16
9348
|
|
NEF
FDSRLAFIIII
310
9
10
16
9349
|
|
NEF
DSRLAFIIII
311
8
10
16
9350
|
|
NEF
AVSQDLDK
48
8
10
16
9351
|
|
NEF
PLRPMTFK
102
8
10
16
9352
|
|
NEF
KGAFDLSF
109
8
10
16
9353
|
|
NEF
GAFDLSFF
110
8
10
16
9354
|
|
NEF
GAVSQDLDK
47
9
10
16
9355
|
|
NEF
QVPLRPMTF
100
9
10
16
9356
|
|
NEF
KGAFDLSFF
109
9
10
16
9357
|
|
NEF
GLEGLIYSK
125
9
10
16
9358
|
|
NEF
MARELHPEY
321
9
10
16
9359
|
|
NEF
VGAVSQDLDK
46
10
10
16
9360
|
|
NEF
QVPLRPMTFK
100
10
10
16
9361
|
|
NEF
GAFDLSFFLK
110
10
10
16
9362
|
|
NEF
GGLEGLIYSK
124
10
10
16
9363
|
|
NEF
CFKLVPVDPR
226
10
10
16
9364
|
|
NEF
HMARELHPEY
320
10
10
16
9365
|
|
NEF
MARELHPEVY
321
10
10
16
9366
|
|
NEF
GVGAVSQDLD
45
11
10
16
9367
|
|
NEF
KGAFDLSFFLK
109
11
10
16
9368
|
|
NEF
KGGLEGLIYSK
122
11
10
16
9369
|
|
NEF
WCFKLVPVDP
225
11
10
16
9370
|
|
NEF
HMARELHPEY
320
11
10
16
9371
|
|
NEF
MARELHPEYY
321
11
10
16
9372
|
|
NEF
AVSRDLEK
48
8
11
17
9373
|
|
NEF
VSRDLEKH
49
8
11
17
9374
|
|
NEF
KLVPVDPR
228
8
11
17
9375
|
|
NEF
GAVSRDLEK
47
9
11
17
0.0002
9376
|
|
NEF
AVSRDLEKH
48
9
11
17
9377
|
|
NEF
VGAVSRDLEK
46
10
11
17
9378
|
|
NEF
GAVSRDLEKH
47
10
11
17
9379
|
|
NEF
VSRDLEKHGA
49
10
11
17
9380
|
|
NEF
NSLLHPICQH
255
10
11
17
9381
|
|
NEF
GVGAVSRDLE
45
11
11
17
9382
|
|
NEF
VGAVSRDLEK
46
11
11
17
9383
|
|
NEF
AVSRDLEKIIG
48
11
11
17
9384
|
|
NEF
AATNADCA
70
8
12
22
9385
|
|
NEF
ATNADCAWLE
71
11
12
22
9386
|
|
NEF
EGENNCLLII
251
9
12
19
9387
|
|
NEF
PMTYKGAF
105
8
12
19
9388
|
|
NEF
YTPGPGVR
207
8
12
19
9389
|
|
NEF
TAATNADCA
69
9
12
19
9390
|
|
NEF
DILDLWVYII
185
9
12
19
9391
|
|
NEF
NTAATNADCA
68
10
12
19
9392
|
|
NEF
QDILDLWVYII
184
10
12
19
9393
|
|
NEF
ITSSNTAATNA
64
11
12
19
9394
|
|
NEF
PLRPMTYKGA
102
11
12
19
9395
|
|
NEF
PGIRYPLTF
211
9
13
21
9396
|
|
NEF
PGTRFPLTF
211
9
13
21
9397
|
|
NEF
EGENNSLLII
251
9
13
21
9398
|
|
NEF
WVYIITQGF
191
8
13
20
9399
|
|
NEF
GIRYPLTF
213
8
13
20
9400
|
|
NEF
GTRFPLTF
213
8
13
20
9401
|
|
NEF
SSNTAATNA
66
9
13
20
9402
|
|
NEF
WVYIITQGFF
191
9
13
20
9403
|
|
NEF
YTPGPGTRF
207
9
13
20
9404
|
|
NEF
TSSNTAATNA
65
10
13
20
9405
|
|
NEF
VDLSIIFLKEK
112
10
13
20
9406
|
|
NEF
DLWVYIITQGF
188
10
13
20
9407
|
|
NEF
AVDLSIIFLKEK
111
11
13
20
9408
|
|
NEF
LDLWVYIITQG
187
11
13
20
9409
|
|
NEF
DLWVYIITQGF
188
11
13
20
9410
|
|
NEF
PGPGIRYPLTF
209
11
13
20
9411
|
|
NEF
PGPGTRFPLTF
209
11
13
20
9412
|
|
NEF
VDLSIIFLK
112
8
14
22
9413
|
|
NEF
DGLIYSKK
172
8
14
22
9414
|
|
NEF
ELIIPEFYK
324
8
14
22
9415
|
|
NEF
AITSSNTAA
63
9
14
22
0.0003
9416
|
|
NEF
AVDLSIIFLK
111
9
14
22
0.0740
9417
|
|
NEF
LDGLIYSKK
171
9
14
22
9418
|
|
NEF
DGLIYSKKR
172
9
14
22
9419
|
|
NEF
SLLIIPICQH
256
9
14
22
9420
|
|
NEF
GAITSSNTAA
62
10
14
22
9421
|
|
NEF
GLDGLIYSKK
125
10
14
22
9422
|
|
NEF
LDGLIYSKKR
171
10
14
22
9423
|
|
NEF
HGAITSSNTAA
61
11
14
22
9424
|
|
NEF
GGLDGLIYSKK
124
11
14
22
9425
|
|
NEF
GLDGLIYSKKR
125
11
14
22
9426
|
|
NEF
PAADGVGA
41
11
15
23
9427
|
|
NEF
ITSSNTAA
64
8
15
23
9428
|
|
NEF
CLLHPMSQII
256
9
15
23
9429
|
|
NEF
NCLLIIPMSQH
255
10
15
23
9430
|
|
NEF
EAQEEEEVGF
82
10
16
25
9431
|
|
NEF
RDLEKIIGA
51
8
16
25
9432
|
|
NEF
LDGLIYSK
171
8
16
25
9433
|
|
NEF
GLDGLIYSK
125
9
16
25
9434
|
|
NEF
GGLDGLIYSK
124
10
16
25
9435
|
|
NEF
KGGLDGLIYSK
122
11
16
25
9436
|
|
NEF
RFPLTFGWCF
216
10
17
27
9437
|
|
NEF
RFPLTFGWCF
216
11
17
27
9438
|
|
NEF
ADCAWLEA
74
8
17
27
9439
|
|
NEF
FFPDWQNY
199
8
17
27
9440
|
|
NEF
LLIIPMSQII
257
8
17
27
9441
|
|
NEF
NADCAWLEA
73
9
17
27
9442
|
|
NEF
GFFPDWQNY
198
9
17
27
9443
|
|
NEF
YTPGPGIRY
207
9
17
27
9444
|
|
NEF
FDLSFFLKEK
112
10
17
27
9445
|
|
NEF
QGFFPDWQNY
196
10
17
27
9446
|
|
NEF
AFDLSFFLKEK
111
11
17
27
9447
|
|
NEF
FDLSFFLK
112
8
18
28
9448
|
|
NEF
LLIIPICQII
257
8
8
28
9449
|
|
NEF
AFDLSFFLK
111
9
18
28
9450
|
|
NEF
GGLEGLIY
124
8
19
30
9451
|
|
NEF
KGGLEGLIY
122
9
19
30
9452
|
|
NEF
DILDLWVY
185
8
20
31
9453
|
|
NEF
YTPGPGIR
207
8
20
31
9454
|
|
NEF
QDILDLWVY
184
9
20
31
9455
|
|
NEF
PLRPMTYKAA
102
10
20
31
9456
|
|
NEF
QVPLRPMTYK
100
11
20
31
9457
|
|
NEF
PAAEGVGA
41
8
21
33
9458
|
|
NEF
GGLDGLIY
124
8
21
33
9459
|
|
NEF
WVYHTQGY
191
8
21
33
9460
|
|
NEF
YTPGPGTR
207
8
21
33
9461
|
|
NEF
PLRPMTYKA
102
9
21
33
9462
|
|
NEF
KGGLDGLIY
122
9
21
33
9463
|
|
NEF
WVYIITQGYF
191
9
21
33
9464
|
|
NEF
DLWVYIITQGY
188
10
21
33
9465
|
|
NEF
LDLWVYIITQG
187
11
21
33
9466
|
|
NEF
DLWVYHTQGY
188
11
21
33
9467
|
|
NEF
LSFFLKEK
114
8
22
34
9468
|
|
NEF
ELIIPEYYK
324
8
22
34
9469
|
|
NEF
DLSFFLKEK
113
9
22
34
9470
|
|
NEF
EILDLWVYH
185
9
22
34
9471
|
|
NEF
GLIYSKKR
173
8
23
36
9472
|
|
NEF
PLRPMTYKGA
102
10
25
39
9473
|
|
NEF
AITSSNTA
63
8
27
42
9474
|
|
NEF
LSHFLKEK
114
8
27
42
9475
|
|
NEF
GAITSSNTA
62
9
27
42
9476
|
|
NEF
DLSHFLKEK
113
9
27
42
9477
|
|
NEF
HGAITSSNTA
61
10
27
42
9478
|
|
NEF
EILDLWVY
185
8
33
52
9479
|
|
NEF
ILDLWVYII
186
8
34
53
9480
|
|
NEF
YFPDWQNY
199
8
36
S6
9481
|
|
NEF
QGYFPDWQNY
196
10
36
56
0.0004
9482
|
|
NEF
LTFGWCFK
221
8
39
61
9483
|
|
NEF
PLTFGWCFK
219
9
39
61
9484
|
|
NEF
PLTFGWCF
219
8
43
67
9485
|
|
NEF
QVPLRPMTY
100
9
46
72
9486
|
|
NEF
QVPLRPMTYK
100
10
46
72
0.6100
9487
|
|
NEF
PVRPQVPLR
95
9
48
75
9488
|
|
NEF
CFPVRPQVPLR
93
11
48
75
9489
|
|
NEF
PLRPMTYK
102
8
49
77
0.0010
9490
|
|
POL
STNSPTSR
32
8
01
33
9491
|
|
POL
RANSPSSR
35
8
01
33
9492
|
|
POL
NSTNSPTSR
31
9
01
33
9493
|
|
POL
PTSRELQVR
36
9
01
33
9494
|
|
POL
QTRANSPSSR
33
10
01
33
9495
|
|
POL
QTRANSPTTR
35
10
01
33
9496
|
|
POL
NSPTSRELQVR
34
11
01
33
9497
|
|
POL
RANSPITR
37
8
01
50
9498
|
|
POL
PSSRELQVR
39
9
01
50
9499
|
|
POL
PSRANSPTSR
24
10
01
50
9500
|
|
POL
NSPSSRELQVR
37
11
01
50
9501
|
|
POL
NSPTTRELQV
39
11
01
50
9502
|
|
POL
ADRQGIVSF
71
9
01
20
9503
|
|
POL
DDRQGPVSF
71
9
01
20
9504
|
|
POL
GADRQGIVSF
70
10
01
20
9505
|
|
POL
GDDRQGPVSF
70
10
01
20
9506
|
|
POL
ADRQGIVSFNF
71
11
01
20
9507
|
|
POL
DDRQGPVSFSF
71
11
01
20
9508
|
|
POL
AGADRQGIVSF
69
11
01
17
9509
|
|
POL
AGDDRQGPVS
69
11
01
17
9510
|
|
POL
GTTLNFPQITF
79
11
01
17
9511
|
|
POL
NLAFPQGEA
5
9
10
16
9512
|
|
POL
NLAFPQGEAR
5
10
10
16
9513
|
|
POL
KTGKYAKMRT
542
11
10
16
9514
|
|
POL
ILIEICGII
149
8
10
16
9515
|
|
POL
LIEICGIIK
150
8
10
16
9516
|
|
POL
YAKMRTAII
546
8
10
16
9517
|
|
POL
LIEICGHKA
150
9
10
16
9518
|
|
POL
RSAHTNDVK
550
9
10
16
9519
|
|
POL
AFPQGEAREF
7
10
10
16
9520
|
|
POL
LIEALLDTGA
106
10
10
16
9521
|
|
POL
TGKYAKMRTA
543
10
10
16
9522
|
|
POL
ETWETWWTD
588
10
10
16
9523
|
|
POL
ETWETWWTE
588
10
10
16
9524
|
|
POL
ETWWTDYWQ
591
10
10
16
9525
|
|
POL
VSLTDTTNQK
659
10
10
16
9526
|
|
POL
LAFPQGEAREF
6
11
10
16
9527
|
|
POL
QLIEALLDTGA
105
11
10
16
9528
|
|
POL
MLTQLGCTLN
176
11
10
16
9529
|
|
POL
TGKYAKMRTA
543
11
10
16
9530
|
|
POL
VVSLTDTTNQ
658
11
10
16
9531
|
|
POL
QTKELQKQIIK
961
11
10
16
9532
|
|
POL
QTRANSPTRR
21
10
11
18
9533
|
|
POL
LDGIDKAQEDII
754
11
11
17
9534
|
|
POL
IGGFIKVK
137
8
11
17
9535
|
|
POL
RIGPENPY
238
8
11
17
9536
|
|
POL
VIPLTEEA
481
8
11
17
9537
|
|
POL
TAHTNDVK
551
8
11
17
9538
|
|
POL
QLTEVVQK
559
8
11
17
9539
|
|
POL
IDKAQEDII
757
8
11
17
9540
|
|
POL
WAGIQQEF
884
8
11
17
9541
|
|
POL
VVPRRKVK
1012
8
11
17
9542
|
|
POL
KIIKDYGK
1019
8
11
17
9543
|
|
POL
GIGGFIKVK
136
9
11
17
9544
|
|
POL
EVIPLTEEA
480
9
11
17
9545
|
|
POL
SLTDTTNQK
660
9
11
17
9546
|
|
POL
GIDKAQEDII
756
9
11
17
9547
|
|
POL
KVVPRRKVK
1011
9
11
17
9548
|
|
POL
GGIGGFIKVK
135
10
11
17
9549
|
|
POL
ISRIGPENPY
236
10
11
17
9550
|
|
POL
STNNETPGIR
323
10
11
17
9551
|
|
POL
ESWTVNDIQK
439
10
11
17
9552
|
|
POL
ETTNQKTELII
663
10
11
17
9553
|
|
POL
DGIDKAQEDH
755
10
11
17
9554
|
|
POL
GSNFTSTTVK
870
10
11
17
9555
|
|
POL
GIQQEFGIPY
886
10
11
17
9556
|
|
POL
SDIQIKELQK
958
10
11
17
9557
|
|
POL
IIKDYGKQMA
1020
10
11
17
9558
|
|
POL
IGGIGGFIKVK
134
11
11
17
9559
|
|
POL
KISRIGPENPY
235
11
11
17
9560
|
|
POL
PSTNNETPGIR
322
11
11
17
9561
|
|
POL
STNNETPGIRY
323
11
11
17
9562
|
|
POL
LTEVIPLTEEA
478
11
11
17
9563
|
|
POL
VVSLTETTNQ
658
11
11
17
9564
|
|
POL
ETTNQKTELII
663
11
11
17
9565
|
|
POL
NGSNFTSTTV
869
11
11
17
9566
|
|
POL
GSNFTSTTVK
870
11
11
17
9567
|
|
POL
ACWWAGIQQE
881
11
11
17
9568
|
|
POL
AGIQQEFGIPY
885
11
11
17
9569
|
|
POL
IDIIASDIQTK
953
11
11
17
9570
|
|
POL
VDIIATDIQTK
953
11
11
17
9571
|
|
POL
ASDIQTKELQK
957
11
11
17
9572
|
|
POL
NSEIKVVPRRK
1007
11
11
17
9573
|
|
POL
KIIKDYGKQMA
1019
11
11
17
9574
|
|
POL
NSLSEAGA
60
8
12
20
9575
|
|
POL
QTRANSPTSR
21
10
12
19
9576
|
|
POL
IIKIQNFR
969
8
12
19
9577
|
|
POL
QIYPGIKVK
458
9
12
19
9578
|
|
POL
QDQWTYQIY
526
9
12
19
9579
|
|
POL
IIKIQNFRVY
969
10
12
19
9580
|
|
POL
ASQIYPGIKVK
456
11
12
19
9581
|
|
POL
IIKIQNFRVYY
969
11
12
19
9582
|
|
POL
LAFPQGEA
6
8
12
19
9583
|
|
POL
LAFPQGKA
6
8
12
19
9584
|
|
POL
AFPQGEAR
7
8
12
19
9585
|
|
POL
KTELQAIY
668
8
12
19
9586
|
|
POL
ELQAIYLA
670
8
12
19
9587
|
|
POL
QIIKIQNF
968
8
12
19
9588
|
|
POL
KDYGKQMA
1022
8
12
19
9589
|
|
POL
LAFPQGEAR
6
9
12
19
9590
|
|
POL
EINLPGKWK
122
9
12
19
9591
|
|
POL
TTNQKIELII
664
9
12
19
9592
|
|
POL
QIIKIQNFR
968
9
12
19
9593
|
|
POL
VIQDNSEIK
1003
9
12
19
9594
|
|
POL
NSEIKVVPR
1007
9
12
19
9595
|
|
POL
VLEEINLPGK
119
10
12
19
9596
|
|
POL
TTNQKTELIIA
664
10
12
19
9597
|
|
POL
KTELQAIYLA
668
10
12
19
9598
|
|
POL
VVIQDNSEIK
1002
10
12
19
9599
|
|
POL
NSEIKVVPRR
1007
10
12
19
9600
|
|
POL
TVLEEINLPGK
118
11
12
19
9601
|
|
POL
EINLPGKWKPK
122
11
12
19
9602
|
|
POL
ELRQIILLRWG
393
11
12
19
9603
|
|
POL
QGQDQWTYQI
524
11
12
19
9604
|
|
POL
RMRGAIITNDV
548
11
12
19
9605
|
|
POL
QIIKIQNFRVY
968
11
12
19
9606
|
|
POL
AVVIQDNSEIK
1000
11
12
19
9607
|
|
POL
QDNSEIKVVPR
1005
11
12
19
9608
|
|
POL
ELQKQIIK
964
8
13
21
9609
|
|
POL
EFSSEQTRA
16
9
13
21
9610
|
|
POL
KTGKYARMR
542
9
13
21
9611
|
|
POL
NLKTGKYARM
540
11
13
21
9612
|
|
POL
KTGKYARMRG
542
11
13
21
9613
|
|
POL
EDINLPGK
121
8
13
20
9614
|
|
POL
IVPLTEEA
481
8
13
20
9615
|
|
POL
TGKYARMR
543
8
13
20
9616
|
|
POL
YARMRGAH
546
8
13
20
9617
|
|
POL
IGQVREQA
914
8
13
20
9618
|
|
POL
QVREQAEII
916
8
13
20
9619
|
|
POL
DINLPGKWK
122
9
13
20
9620
|
|
POL
LIEICGKKA
150
9
13
20
9621
|
|
POL
DIVPLTEEA
480
9
13
20
9622
|
|
POL
IIGQVREQA
913
9
13
20
9623
|
|
POL
VLEDINLPGK
119
10
13
20
9624
|
|
POL
EDINLPGKWK
121
10
13
20
9625
|
|
POL
ILIEICGKKA
149
10
13
20
9626
|
|
POL
RAKILELREH
388
10
13
20
9627
|
|
POL
TVQPIVLPEK
429
10
13
20
0.1600
9628
|
|
POL
TDIVPLTEEA
479
10
13
20
9629
|
|
POL
TGKYARMRGA
543
10
13
20
9630
|
|
POL
AGRWPVKTIII
857
10
13
20
9631
|
|
POL
KIIGQVREQA
912
10
13
20
9632
|
|
POL
IGQVREQAEH
914
10
13
20
9633
|
|
POL
QVREQAEIILK
916
10
13
20
9634
|
|
POL
EIKVVPRRKA
1009
10
13
20
9635
|
|
POL
TLWQRVLVTV
91
11
13
20
9636
|
|
POL
LVTIKIGGQLK
97
11
13
20
9637
|
|
POL
TVLEDINLPGK
118
11
13
20
9638
|
|
POL
DINLPGKWKP
122
11
13
20
9639
|
|
POL
QILIEICGKKA
148
11
13
20
9640
|
|
POL
KIEELRIEIILLK
390
11
13
20
9641
|
|
POL
WTVQVIPLPEK
428
11
13
20
0.0011
9642
|
|
POL
LTDIVPLTEEA
478
11
13
20
9643
|
|
POL
TGKYARMRGA
543
11
13
20
9644
|
|
POL
LAGRWPVKTI
856
11
13
20
9645
|
|
POL
IIGQVREQAEII
913
11
13
20
9646
|
|
POL
DSRDPLWKGP
981
11
13
20
9647
|
|
POL
EIKVVPRRKAK
1009
11
13
20
9648
|
|
POL
EFSSEQTR
16
8
14
22
9649
|
|
POL
QIYPGIKVR
458
9
14
22
9650
|
|
POL
ASQIYVGIKVR
456
11
14
22
9651
|
|
POL
IATESIVIWGK
567
11
14
22
9652
|
|
POL
ILIEICGK
149
8
14
22
9653
|
|
POL
LIEICGKK
150
8
14
22
9654
|
|
POL
NFTSTTVK
872
8
14
22
9655
|
|
POL
FTSTTVKA
873
8
14
22
9656
|
|
POL
TSTTVKAA
874
8
14
22
9657
|
|
POL
IASDIQTK
956
8
14
22
9658
|
|
POL
DSRDPLWK
981
8
14
22
9659
|
|
POL
QILIEICGK
148
9
14
22
9660
|
|
POL
ILIEICGKK
149
9
14
22
9661
|
|
POL
NFTSTTVKA
872
9
14
22
9662
|
|
POL
FTSTTVKAA
873
9
14
22
0.0003
9663
|
|
POL
IIASDIQTK
955
9
14
22
9664
|
|
POL
RDSRDPLWK
980
9
I4
22
9665
|
|
POL
RDPLWKGPA
983
9
4
22
9666
|
|
POL
QILIEICGKK
148
10
14
22
9667
|
|
POL
RTKIEELRQH
388
10
14
22
9668
|
|
POL
PGIKVRQLCK
461
10
14
22
9669
|
|
POL
TIHTDNGSNF
864
10
14
22
9670
|
|
POL
NFTSTTVKAA
872
10
14
22
9671
|
|
POL
TTVKAACWW
876
10
14
22
0.0006
9672
|
|
POL
AGERIVDIIA
948
10
14
22
9673
|
|
POL
DIIASDIQTK
954
10
14
22
9674
|
|
POL
RDPLWKGPAK
983
10
14
22
9675
|
|
POL
FSFPQITLWQR
85
11
14
22
9676
|
|
POL
YDQILIEICGK
146
11
14
22
9677
|
|
POL
ELREIILLKWG
393
11
14
22
9678
|
|
POL
KTPKFKLPIQK
577
11
14
22
9679
|
|
POL
GIDKAQEEHER
756
11
14
22
9680
|
|
POL
STTVKAACW
875
11
14
22
9681
|
|
POL
SAGERIVDIIA
947
11
14
22
9682
|
|
POL
QTRANSPTR
21
9
15
24
9683
|
|
POL
LVEICTEMEK
221
10
15
24
0.0002
9684
|
|
POL
FFRLDLAF
1
8
15
23
9685
|
|
POL
FSSEQTRA
17
8
15
23
9686
|
|
POL
ELRQIILLR
393
8
15
23
9687
|
|
POL
QGQDQWTY
524
8
15
23
9688
|
|
POL
KTELQAIII
668
8
15
23
9689
|
|
POL
AGIRKVLF
746
8
15
23
9690
|
|
POL
PIQKETWEA
584
9
15
23
9691
|
|
POL
SAGIRKVLF
745
9
15
23
9692
|
|
POL
EIKVVPRRK
1009
9
15
23
9693
|
|
POL
LTQLGCTLNF
177
10
15
23
9694
|
|
POL
KTELQAIIILA
668
10
15
23
9695
|
|
POL
LGIIQAQPDR
695
10
15
23
9696
|
|
POL
VDKLVSAGIR
740
10
15
23
9697
|
|
POL
VSAGIRKVLF
744
10
15
23
9698
|
|
POL
IDKAQEEIIER
757
10
15
23
9699
|
|
POL
ALVEICTEMEK
220
11
15
23
9700
|
|
POL
KIEELRQIILLR
390
11
15
23
9701
|
|
POL
ALGIIQAQPDR
694
11
15
23
9702
|
|
POL
LVNQIIEQLIK
709
11
15
23
9703
|
|
POL
QVDKLVSAGIR
739
11
15
23
9704
|
|
POL
VDKLVSAGIRK
740
11
15
23
9705
|
|
POL
LVSAGIRKVLF
743
11
15
23
9706
|
|
POL
IDKAQEEHERY
757
11
15
23
9707
|
|
POL
KAQEEHER
759
8
16
25
9708
|
|
POL
NLAFQQGEA
5
9
16
25
9709
|
|
POL
KAQEEHERY
759
9
16
25
9710
|
|
POL
NLAFQQGEAR
5
10
16
25
9711
|
|
POL
KAQEEHERYII
759
10
16
25
9712
|
|
POL
LAFQQGEA
6
8
16
25
9713
|
|
POL
AFQQGEAR
7
8
16
25
9714
|
|
POL
RANSPTRR
26
8
16
25
9715
|
|
POL
QLGCTLNF
179
8
16
25
9716
|
|
POL
SAIITNDVK
551
8
16
25
9717
|
|
POL
ELQAIHLA
670
8
16
25
9718
|
|
POL
IIQAQPDR
697
8
16
25
9719
|
|
POL
QVDKLVSA
739
8
16
25
9720
|
|
POL
KLVSAGIR
742
8
16
25
9721
|
|
POL
LVSAGIRK
743
8
16
25
0.0091
9722
|
|
POL
EIKVVPRR
1009
8
16
25
9723
|
|
POL
LAFQQGEAR
6
9
16
25
9724
|
|
POL
GIIQAQPDR
696
9
16
25
9725
|
|
POL
KLVSAGIRK
742
9
16
25
0.1300
9726
|
|
POL
QLEKEPIVGA
620
10
16
25
9727
|
|
POL
RANSPTSR
26
8
17
27
9728
|
|
POL
KIEELRQII
390
8
17
27
9729
|
|
POL
ELREHLLK
393
8
17
27
9730
|
|
POL
WGKTPKFK
575
8
17
27
9731
|
|
POL
TIKIGGQLK
99
9
17
27
0.2700
9732
|
|
POL
VTIKIGGQLK
98
10
17
27
0.0370
9733
|
|
POL
TVQPIQLPEK
429
10
17
27
9734
|
|
POL
VIWGKTPKFK
573
10
17
27
9735
|
|
POL
TLWQRPLVTI
91
11
17
27
9736
|
|
POL
TIKIGGQLKEA
99
11
17
27
9737
|
|
POL
MLTQIGCTLNF
176
11
17
27
9738
|
|
POL
WTVQPIQLPEK
428
11
17
27
9739
|
|
POL
IVIWGKTPKFK
572
11
17
27
9740
|
|
POL
ETTNQKTELQ
663
11
17
27
9741
|
|
POL
KDFRKYTAF
311
9
18
29
9742
|
|
POL
YFSVPLDKDF
304
10
18
29
9743
|
|
POL
YFSVPLDKDFR
304
11
18
29
9744
|
|
POL
NLKTGKYAKM
540
11
18
29
9745
|
|
POL
SVPLDKDF
306
8
18
28
9746
|
|
POL
PDIVIYQY
365
8
18
28
9747
|
|
POL
FSVPLDKDF
305
9
18
28
9748
|
|
POL
SVPLDKDFR
306
9
18
28
9749
|
|
POL
FSVPLDKDFR
305
10
18
28
9750
|
|
POL
SVPLDKDFRK
306
10
18
28
9751
|
|
POL
AGIKVKQLCK
461
10
18
28
9752
|
|
POL
FSVPLDKDFRK
305
11
18
28
9753
|
|
POL
SVPLDKDFRK
306
11
18
28
9754
|
|
POL
LDKDFRKYTA
309
11
18
28
9755
|
|
POL
YAGIKVKQLCK
460
11
18
28
9756
|
|
POL
LVSQIIEQLIK
709
11
18
28
9757
|
|
POL
PLDKDFRK
308
8
19
30
9758
|
|
POL
KDFRKYTA
311
8
19
30
9759
|
|
POL
PLDKDFRKY
308
9
19
30
9760
|
|
POL
KTGKYAKMR
542
9
19
30
9761
|
|
POL
PLDKDFRKYT
308
11
19
30
9762
|
|
POL
LDKDFRKY
309
8
19
30
9763
|
|
POL
KIEELREII
390
8
19
30
9764
|
|
POL
TGKYAKMR
543
8
19
30
9765
|
|
POL
GAIITNDVK
551
8
19
30
9766
|
|
POL
LTDTTNQK
661
8
19
30
9767
|
|
POL
PLWKGPAK
985
8
19
30
9768
|
|
POL
GIKVRQLCK
462
9
19
30
9769
|
|
POL
RGAHTNDVK
550
9
19
30
9770
|
|
POL
LDKDFRKYTA
309
10
19
30
9771
|
|
POL
KVRQLCKLLR
464
10
19
30
9772
|
|
POL
ATESIVIWGK
568
10
19
30
9773
|
|
POL
VSQIIEQLIK
710
10
19
30
0.0007
9774
|
|
POL
MAGDDCVASR
1028
10
19
30
9775
|
|
POL
VSQIIEQLIKK
710
11
19
30
9776
|
|
POL
QLIKKEKVYLA
716
11
19
30
9777
|
|
POL
QMAGDDCVAS
1027
11
19
30
9778
|
|
POL
QIYAGIKVK
458
9
20
32
9779
|
|
POL
KVYLAWVPA
722
9
20
32
0.0750
9780
|
|
POL
KVYLAWVPAH
722
10
20
32
0.0280
9781
|
|
POL
KAACWWAGIK
879
10
20
32
0.0300
9782
|
|
POL
ASQIYAGIKVK
456
11
20
32
9783
|
|
POL
KVYLAWVPAII
722
11
20
32
8.6000
9784
|
|
POL
KFKLPIQK
580
8
20
31
9785
|
|
POL
GDDCVASR
1030
8
20
31
9786
|
|
POL
AGDDCVASR
1029
9
20
31
9787
|
|
POL
VSLTETTNQK
659
10
20
31
9788
|
|
POL
LIKKEKVYLA
717
10
20
31
9789
|
|
POL
LLKLAGRWPV
853
11
20
31
9790
|
|
POL
YFSVPLDK
304
8
21
33
9791
|
|
POL
KVIIITDNGSNF
863
11
21
33
9792
|
|
POL
ACWWAGIK
881
8
21
33
9793
|
|
POL
WAGIKQEF
884
8
21
33
9794
|
|
POL
SLTETTNQK
660
9
21
33
9795
|
|
POL
AACWWAGIK
880
9
21
33
0.0130
9796
|
|
POL
DAYFSVPLDK
302
10
21
33
9797
|
|
POL
DLEIGQIIRTK
381
10
21
33
9798
|
|
POL
QLCKLLRGTK
467
10
21
33
9799
|
|
POL
SDFNLPPIVA
776
10
21
33
9800
|
|
POL
LLTQIGCTLNF
176
11
21
33
9801
|
|
POL
IFAIKKKDSTK
249
11
21
33
9802
|
|
POL
GDAYFSVPLD
301
11
21
33
9803
|
|
POL
SDLEIGQIIRTK
380
11
21
33
9804
|
|
POL
QLCKLLRGTK
467
11
21
33
9805
|
|
POL
ASDFNLPPIVA
775
11
21
33
9806
|
|
POL
SDFNLPPIVAK
776
11
21
33
9807
|
|
POL
ACWWAGIKQE
881
11
21
33
9808
|
|
POL
AGIKQEFGIPY
885
11
21
33
9809
|
|
POL
EDFRKYTA
311
8
22
35
9810
|
|
POL
EDFRKYTAF
311
9
22
35
9811
|
|
POL
EIGQIIRTK
383
8
22
34
9812
|
|
POL
RTKIEELR
388
8
22
34
9813
|
|
POL
YLAWVPAH
724
8
22
34
9814
|
|
POL
LAWVPAHK
725
8
22
34
9815
|
|
POL
YLAWVPAIIK
724
9
22
34
0.0770
9816
|
|
POL
NFPQITLWQR
86
10
22
34
9817
|
|
POL
MTKILEPFRK
353
10
22
34
0.0150
9818
|
|
POL
KVILVAVHVA
823
10
22
34
9819
|
|
POL
AGRWPVKVIH
857
10
22
34
9820
|
|
POL
GIKQEFGIPY
886
10
22
34
0.0002
9821
|
|
POL
SMTKILEPFRK
352
11
22
34
9822
|
|
POL
KTPKFRLPIQK
577
11
22
34
9823
|
|
POL
LAGRWPVKVI
856
11
22
34
9824
|
|
POL
KVYLSWVPA
722
9
23
37
9825
|
|
POL
KVYLSWVPAII
722
10
23
37
9826
|
|
POL
KVYLSWVPAII
722
11
23
37
9827
|
|
POL
KILEPFRK
355
8
23
36
9828
|
|
POL
EGKVILVA
821
8
23
36
9829
|
|
POL
KVILVAVH
823
8
23
36
9830
|
|
POL
KIGGQLKEA
101
9
23
36
9831
|
|
POL
DFNLPPIVA
777
9
23
36
9832
|
|
POL
VILVAVIIVA
824
9
23
36
9833
|
|
POL
TVKAACWWA
877
9
23
36
9834
|
|
POL
SFPQITLWQR
86
10
23
36
9835
|
|
POL
DFNLPPIVAK
777
10
23
36
9836
|
|
POL
IILEGKVILVA
819
10
23
36
9837
|
|
POL
EGKVILVAVH
821
10
23
36
9838
|
|
POL
LLKWGFTTPD
398
11
23
36
9839
|
|
POL
LLRWGFTTPD
398
11
23
36
9840
|
|
POL
IDIIATDIQTK
953
11
23
36
9841
|
|
POL
KLLRGTKA
470
8
24
38
9842
|
|
POL
NTPIFAIK
246
8
24
38
9843
|
|
POL
GDDCVAGR
1030
8
24
38
9844
|
|
POL
NTPIFAIKK
246
9
24
38
9845
|
|
POL
LCKLLRGTK
468
9
24
38
0.0004
9846
|
|
POL
AGDDCVAGR
1029
9
24
38
9847
|
|
POL
NTPIFAIKKK
246
10
24
38
9848
|
|
POL
LCKLLRGTKA
468
10
24
38
9849
|
|
POL
VIIITDNGSNF
864
10
24
38
9850
|
|
POL
MAGDDCVAGR
1028
10
24
38
9851
|
|
POL
QLCKLLRGAK
467
11
24
38
9852
|
|
POL
QGQGQWTYQI
524
11
24
38
9853
|
|
POL
KLGKAGYVTD
643
11
24
38
9854
|
|
POL
TAYFLLKLAG
849
11
24
38
9855
|
|
POL
QMAGDDCVAG
1027
11
24
38
9856
|
|
POL
KLLRGAKA
470
8
25
40
9857
|
|
POL
QGQWTYQIY
526
9
25
40
0.0004
9858
|
|
POL
IGGQLKEA
102
8
25
39
9859
|
|
POL
PIFAIKKK
248
8
25
39
9860
|
|
POL
QGQGQWTY
524
8
25
39
9861
|
|
POL
FLLKLAGR
852
8
25
39
9862
|
|
POL
QLCKLLRGA
467
9
25
39
9863
|
|
POL
PIVAKEIVA
782
9
25
39
9864
|
|
POL
YFLLKLAGR
851
9
25
39
9865
|
|
POL
QLCKLLRGAK
467
10
25
39
9866
|
|
POL
LCKLLRGAKA
468
10
25
39
9867
|
|
POL
LGKAGYVTDR
644
10
25
39
9868
|
|
POL
IDKAQEEIIEK
757
10
25
39
9869
|
|
POL
SDFNLPPVVA
776
10
25
39
9870
|
|
POL
PSKDLIAEIQK
513
11
25
39
9871
|
|
POL
DTTNQKTELQ
663
11
25
39
9872
|
|
POL
GIDKAQEEHEK
756
11
25
39
9873
|
|
POL
IDKAQEEIIEKY
757
11
25
39
9874
|
|
POL
ASDFNLPPVVA
775
11
25
39
9875
|
|
POL
SDFNLPPVVAK
776
11
25
39
9876
|
|
POL
RAKIEELR
388
8
26
41
9877
|
|
POL
LCKLLRGA
468
8
26
41
9878
|
|
POL
KFRLPIQK
580
8
26
41
9879
|
|
POL
NLPPIVAK
779
8
26
41
9880
|
|
POL
IVAKEIVA
783
8
26
41
9881
|
|
POL
LCKLLRGAK
468
9
26
41
9882
|
|
POL
LTEAVQKIA
560
9
26
41
9883
|
|
POL
SSGIRKVLF
745
9
26
41
9884
|
|
POL
DFNLPPVVA
777
9
26
41
9885
|
|
POL
QLTEAVQKIA
559
10
26
41
9886
|
|
POL
VSSGIRKVLF
744
10
26
41
9887
|
|
POL
DFNLPPVVAK
777
10
26
41
9888
|
|
POL
GSNFTSAAVK
870
10
26
41
9889
|
|
POL
LVSSGIRKVLF
743
11
26
41
9890
|
|
POL
TGQETAYFLL
845
11
26
41
9891
|
|
POL
NGSNFTSAAV
869
11
26
41
9892
|
|
POL
GSNFTSAAVK
870
11
26
41
9893
|
|
POL
KAQEEIIEK
759
8
27
43
9894
|
|
POL
ASQIYAGIK
456
9
27
43
0.0013
9895
|
|
POL
KAQEEIIEKY
759
9
27
43
9896
|
|
POL
KAQEEIIEKYII
759
10
27
43
9897
|
|
POL
EICTEMEK
223
8
27
42
9898
|
|
POL
EIGQIIRAK
383
8
27
42
9899
|
|
POL
LVSSGIRK
743
8
27
42
9900
|
|
POL
SGIRKVLF
746
8
27
42
9901
|
|
POL
NLPPVVAK
779
8
27
42
9902
|
|
POL
ETAYFLLK
848
8
27
42
0.0037
9903
|
|
POL
TSAAVKAA
874
8
27
42
9904
|
|
POL
KLVSSGIRK
742
9
27
42
9905
|
|
POL
TAYFLLKLA
849
9
27
42
0.0027
9906
|
|
POL
FTSAAVKAA
873
9
27
42
9907
|
|
POL
DLEIGQIIRAK
381
10
27
42
9908
|
|
POL
KLNWASQIYA
452
10
27
42
0.0052
9909
|
|
POL
WASQIYAGIK
455
10
27
42
9910
|
|
POL
KVKQLCKLLR
464
10
27
42
9911
|
|
POL
ETAYFLLKLA
848
10
27
42
9912
|
|
POL
NFTSAAVKAA
872
10
27
42
9913
|
|
POL
EICTEMEKEGK
223
11
27
42
9914
|
|
POL
SDLEIGQIIRAK
380
11
27
42
9915
|
|
POL
VDKLVSSGIRK
740
11
27
42
9916
|
|
POL
ASQIYPGIK
456
9
28
44
9917
|
|
POL
KDLIAEIQK
515
9
28
44
9918
|
|
POL
NLKTGKYAK
540
9
28
44
9919
|
|
POL
DLIAEIQK
516
8
28
44
9920
|
|
POL
PIVGAETF
625
8
28
44
9921
|
|
POL
IVGAETFY
626
8
28
44
9922
|
|
POL
GSNFTSAA
870
8
28
44
9923
|
|
POL
NFTSAAVK
872
8
28
44
9924
|
|
POL
FTSAAVKA
873
8
28
44
9925
|
|
POL
CTEMEKEGK
225
9
28
44
0.0002
9926
|
|
POL
DLEIGQIIRA
381
9
28
44
9927
|
|
POL
GIKVKQLCK
462
9
28
44
9928
|
|
POL
PIVGAETFY
625
9
28
44
9929
|
|
POL
QLIKKEKVY
716
9
28
44
9930
|
|
POL
PYVAKEIVA
782
9
28
44
9931
|
|
POL
NGSNFTSAA
869
9
28
44
9932
|
|
POL
NFTSAAVKA
872
9
28
44
9933
|
|
POL
ICTEMEKEGK
224
10
28
44
9934
|
|
POL
SDLEIGQIIRA
380
10
28
44
9935
|
|
POL
WASQIYPGIK
455
10
28
44
9936
|
|
POL
AAVKAACWW
876
10
28
44
9937
|
|
POL
GSDLEIGQIIRA
379
11
28
44
9938
|
|
POL
VGAEIFYVDG
627
11
28
44
9939
|
|
POL
TDNGSNFTSA
867
11
28
44
9940
|
|
POL
SAAVKAACW
875
11
28
44
9941
|
|
POL
NLKTGKYAR
540
9
29
46
0.0008
9942
|
|
POL
KLVSSGIR
742
8
29
45
9943
|
|
POL
VIWGKTPKFR
573
10
29
45
9944
|
|
POL
VDKLVSSGIR
740
10
29
45
9945
|
|
POL
PLTEAELELA
483
11
29
45
9946
|
|
POL
IVIWGKTPKFR
572
11
29
45
9947
|
|
POL
QVDKLVSSGIR
739
11
29
45
9948
|
|
POL
WGKTPKFR
575
8
30
47
9949
|
|
POL
LTETTNQK
661
8
30
47
9950
|
|
POL
IILVAVIIVA
824
9
30
47
9951
|
|
POL
AANRETKLGK
637
10
30
47
0.0007
9952
|
|
POL
IIEQLIKKEK
713
10
30
47
0.0004
9953
|
|
POL
KIILVAVIIVA
823
10
30
47
9954
|
|
POL
GAANRETKLG
636
11
30
47
9955
|
|
POL
AANRETKLGK
637
11
30
47
9956
|
|
POL
QIIEQLIKKEK
712
11
30
47
9957
|
|
POL
ILKLAGRWPV
853
11
30
47
9958
|
|
POL
VVAKEIVA
783
8
31
48
9959
|
|
POL
EGKIILVA
821
8
31
48
9960
|
|
POL
KIILYAVII
823
8
31
48
9961
|
|
POL
ETAYFILK
848
8
31
48
9962
|
|
POL
YFILKLAGR
851
9
31
48
9963
|
|
POL
HLEGKIILVA
819
10
31
48
9964
|
|
POL
EGKIILVAVII
821
10
31
48
9965
|
|
POL
ETAYFILKLA
848
10
31
48
9966
|
|
POL
PSINNETPGIR
322
11
31
48
9967
|
|
POL
TGQETAYFILK
845
11
31
48
9968
|
|
POL
TAYFILKLAGR
849
11
31
48
9969
|
|
POL
FILKLAGR
852
8
32
50
9970
|
|
POL
NDVKQLTEA
555
9
32
50
9971
|
|
POL
TAYFILKLA
849
9
32
50
9972
|
|
POL
AVKAACWWA
877
9
32
50
9973
|
|
POL
SINNETPGIR
323
10
32
50
9974
|
|
POL
SINNETPGIRY
323
11
32
50
9975
|
|
POL
SSMTKILEPFR
351
11
32
50
9976
|
|
POL
HTNDVKQLTE
553
11
32
50
9977
|
|
POL
IISNWRAMAS
768
11
32
50
9978
|
|
POL
QTKELQKQITK
961
11
32
50
0.0050
9979
|
|
POL
DVKQLTEA
556
8
33
52
9980
|
|
POL
NGSNFTSA
869
8
33
52
9981
|
|
POL
EMEKEGKISK
229
10
33
52
0.0004
9982
|
|
POL
SSMTKILEPF
351
10
33
52
0.0004
9983
|
|
POL
TDNGSNFTSA
867
10
33
52
9984
|
|
POL
QSSMTKILEPF
350
11
33
52
9985
|
|
POL
DVKQLTEAVQ
556
11
33
52
0.0048
9986
|
|
POL
IITDNGSNFTS
866
11
33
52
9987
|
|
POL
YDPSKDLIA
511
9
34
53
9988
|
|
POL
DIIATDIQTK
954
10
34
53
0.0056
9989
|
|
POL
QLKEALLDTG
105
11
34
53
9990
|
|
POL
ELQKQITK
964
8
35
56
9991
|
|
POL
LIKKEKVY
717
8
35
55
9992
|
|
POL
QITKIQNF
968
8
35
55
9993
|
|
POL
DSRDPIWK
981
8
35
55
9994
|
|
POL
ETKLGKAGY
641
9
35
55
9995
|
|
POL
IIATDIQTK
955
9
35
55
0.0250
9996
|
|
POL
QITKIQNFR
968
9
35
55
0.0021
9997
|
|
POL
RDSRDPIWK
980
9
35
55
9998
|
|
POL
TDIQTKELQK
958
10
35
55
0.0007
9999
|
|
POL
RDPIWKGPAK
983
10
35
55
10000
|
|
POL
ATDIQTKELQK
957
11
35
55
0.0051
10001
|
|
POL
QITKIQNFRVY
968
11
35
55
10002
|
|
POL
DSRDPIWKGP
981
11
35
55
10003
|
|
POL
SDIKVVPRRKA
1008
11
35
55
10004
|
|
POL
ITKIQNFR
969
11
36
57
10005
|
|
POL
ITKIQNFRVY
969
10
36
57
0.0016
10006
|
|
POL
ITKIQNFRVYY
969
11
36
57
10007
|
|
POL
IATDIQTK
956
8
36
56
10008
|
|
POL
PIWKGPAK
985
8
36
56
10009
|
|
POL
NLPGKWKPK
124
9
36
56
10010
|
|
POL
AIFQSSMTK
347
9
36
56
1.1000
10011
|
|
POL
PAIFQSSMTK
346
10
36
56
0.0760
10012
|
|
POL
LTEEAELELA
484
10
36
56
10013
|
|
POL
VFAIKKKDSTK
249
11
36
56
10014
|
|
POL
NTPVFAIK
246
8
37
58
0.0003
10015
|
|
POL
PVFAIKKK
248
8
37
58
0.0003
10016
|
|
POL
QLTEAVQK
559
8
37
58
10017
|
|
POL
QIIEQLIK
712
8
37
58
10018
|
|
POL
IIEQLIKK
713
8
37
58
10019
|
|
POL
YLSWVPAII
724
8
37
58
10020
|
|
POL
LSWVPAIIK
725
8
37
58
10021
|
|
POL
NTPVFAIKK
246
9
37
58
0.0330
10022
|
|
POL
QIIEQLIKK
712
9
37
58
0.0091
10023
|
|
POL
YLSWVPAIIK
724
9
37
58
10024
|
|
POL
RDPIWKGPA
983
9
37
58
10025
|
|
POL
VIQDNSDIK
1003
9
37
58
0.0009
10026
|
|
POL
NTPVFAIKKK
246
10
37
58
0.0006
10027
|
|
POL
VVIQDNSDIK
1002
10
37
58
0.0005
10028
|
|
POL
AVVIQDNSDIK
1000
11
37
58
0.0004
10029
|
|
POL
IFQSSMTK
348
8
38
59
0.0055
10030
|
|
POL
ILKEPVIIGVYY
498
11
38
59
10031
|
|
POL
LDGIDKAQEEII
754
11
39
62
10032
|
|
POL
IISNWRAMA
768
8
39
61
10033
|
|
POL
AGYVIDRGR
647
9
39
61
10034
|
|
POL
YVTDRGRQK
649
9
39
61
0.0011
10035
|
|
POL
KAGYVTDRGR
646
10
39
61
10036
|
|
POL
LGIIQAQVDK
695
10
39
61
0.0007
10037
|
|
POL
DGIDKAQEEII
755
10
39
61
10038
|
|
POL
DIKVVVRRKA
1009
10
39
61
10039
|
|
POL
VVIIGVYYDPS
505
11
39
61
10040
|
|
POL
AGYVTDRGRQ
647
11
39
61
10041
|
|
POL
ALGIIQAQPDK
694
11
39
61
10042
|
|
POL
DIKVVPRRKAK
1009
11
39
61
10043
|
|
POL
VTDRGRQK
650
8
40
63
0.0090
10044
|
|
POL
IIQAQPDK
697
8
40
63
10045
|
|
POL
GIIQAQVDK
696
9
40
63
0.0009
10046
|
|
POL
GIDKAQEEII
756
9
40
63
10047
|
|
POL
NSDIKVVVR
1007
9
40
63
10048
|
|
POL
ILKEPVHGVY
498
10
40
63
10049
|
|
POL
NSDIKVVPRR
1007
10
40
63
0.0007
10050
|
|
POL
EILKEPVIIGVY
497
11
40
63
10051
|
|
POL
WTYQIYQEPF
529
11
40
63
0.9200
10052
|
|
POL
QIYQIEPFKNLK
532
11
40
63
0.2800
10053
|
|
POL
SAGERIIDIIA
947
11
40
63
10054
|
|
POL
QDNSDIKVVPR
1005
11
40
63
10055
|
|
POL
NSDIKVVPRRK
1007
11
40
63
10056
|
|
POL
ESIVIWGKTPK
570
11
41
65
10057
|
|
POL
FFRENLAF
1
8
41
64
10058
|
|
POL
QIGCTLNF
179
8
41
64
10059
|
|
POL
QIYQEPFK
532
8
41
64
0.0010
10060
|
|
POL
IDKAQEIEII
757
8
41
64
10061
|
|
POL
KAKIIRDY
1017
8
41
64
10062
|
|
POL
LTQIGCTLNF
177
10
41
64
0.0081
10063
|
|
POL
AGERIIDIIA
948
10
41
64
10064
|
|
POL
KAKIIRDYGK
1017
10
41
64
0.0048
10065
|
|
POL
KISKIGPENPY
235
11
41
64
10066
|
|
POL
SIVIWGKTPKF
571
11
41
64
10067
|
|
POL
DFRKYTAF
312
8
42
66
10068
|
|
POL
KAGYVTDR
646
8
42
66
10069
|
|
POL
ISKIGPENPY
236
10
42
66
10070
|
|
POL
SMTKILEPFR
352
10
42
66
0.0004
10071
|
|
POL
WTYQIYQEPF
529
10
42
66
10072
|
|
POL
SIVIWGKTPK
571
10
42
66
10073
|
|
POL
TTNQKTELQA
664
10
42
66
0.0004
10074
|
|
POL
IVIYQYMDDLY
367
11
42
66
10075
|
|
POL
VVPRRKAKIIR
1012
11
42
66
10076
|
|
POL
GVYYDPSK
508
8
43
67
10077
|
|
POL
SCDKCQLK
791
8
43
67
10078
|
|
POL
SMTKILEPF
352
9
43
67
0.0004
10079
|
|
POL
MTKILEPFR
353
9
43
67
0.0008
10080
|
|
POL
HGVYYDPSK
507
9
43
67
0.0004
10081
|
|
POL
ASCDKCQLK
790
9
43
67
0.0027
10082
|
|
POL
DSWTVNDIQK
439
10
43
67
0.0007
10083
|
|
POL
TFYVDGAANR
631
10
43
67
0.0003
10084
|
|
POL
VASCDKCQLK
789
10
43
67
0.0004
10085
|
|
POL
KIIGQVRDQA
912
10
43
67
10086
|
|
POL
KDSWTVNDIQ
438
11
43
67
10087
|
|
POL
ETFYVDGAAN
630
11
43
67
10088
|
|
POL
IVASCDKCQLK
788
11
43
67
0.0970
10089
|
|
POL
SCDKCQLKGE
791
11
43
67
10090
|
|
POL
MIKILEPF
353
8
44
69
10091
|
|
POL
IGQVRDQA
914
8
44
69
10092
|
|
POL
SDIKVVPR
1008
8
44
69
10093
|
|
POL
MAGDDCVA
1028
8
44
69
10094
|
|
POL
IIGQVRDQA
913
9
44
69
10095
|
|
POL
SDIKVVPRR
1008
9
44
69
0.0002
10096
|
|
POL
QMAGDDCVA
1027
9
44
69
0.0003
10097
|
|
POL
VDGAANRETK
634
10
44
69
10098
|
|
POL
IGQVRDQAEH
914
10
44
69
10099
|
|
POL
QVRDQAEIILK
916
10
44
69
0.0089
10100
|
|
POL
SDIKVVPRRK
1008
10
44
69
0.0004
10101
|
|
POL
PFKNLKTGKY
537
11
44
69
10102
|
|
POL
GAETFYVDGA
628
11
44
69
10103
|
|
POL
YVDGAANRET
633
11
44
69
10104
|
|
POL
IIGQVRDQAEII
913
11
44
69
10105
|
|
POL
VAKEIVASCDK
784
11
45
71
10106
|
|
POL
GAANRETK
636
8
45
70
10107
|
|
POL
EIVASCDK
787
8
45
70
10108
|
|
POL
DGAANRETK
635
9
45
70
10109
|
|
POL
PFKNLKTGKY
537
10
45
70
0.0004
10110
|
|
POL
RDQAEIILKTA
918
10
45
70
10111
|
|
POL
PLVKLWYQLE
613
11
45
70
10112
|
|
POL
EILKEPVII
497
8
46
72
10113
|
|
POL
KLWYQLEK
616
8
46
72
10114
|
|
POL
RDQAEIILK
918
8
46
72
10115
|
|
POL
PFKNLKTGK
537
9
46
72
10116
|
|
POL
DIQTKELQK
959
9
46
72
0.0009
10117
|
|
POL
LVKLWYQLEK
614
10
46
72
0.0560
10118
|
|
POL
KVKQWPLTEE
207
11
46
72
0.0750
10119
|
|
POL
VIWGKTPKF
573
9
47
73
10120
|
|
POL
IVIWGKIPKF
572
10
47
73
10121
|
|
POL
VIWGKTPK
573
8
48
75
10122
|
|
POL
QVRDQAEH
916
8
48
75
10123
|
|
POL
DIKVVPRR
1009
8
48
75
10124
|
|
POL
IVIWGKTPK
572
9
48
75
0.0850
10125
|
|
POL
DIKVVPRRK
1009
9
48
75
0.0002
10126
|
|
POL
GAETFYVDGA
628
10
48
75
10127
|
|
POL
KVLFLDGIDK
750
10
48
75
0.3600
10128
|
|
POL
CDKCQLKGEA
792
10
48
75
10129
|
|
POL
KCQLKGEAMH
794
10
48
75
10130
|
|
POL
VVESMNKELK
902
10
48
75
10131
|
|
POL
KVLFLDGIDKA
750
11
48
75
10132
|
|
POL
GVVESMNKEL
901
11
48
75
10133
|
|
POL
VVESMNKELK
902
11
48
75
10134
|
|
POL
GVVESMNK
901
8
49
77
10135
|
|
POL
RDYGKQMA
1022
8
49
77
10136
|
|
POL
QGVVESMNK
900
9
49
77
10137
|
|
POL
KLKPGMDGPK
197
10
49
77
0.3900
10138
|
|
POL
IIRDYGKQMA
1020
10
49
77
10139
|
|
POL
QSQGVVESMN
898
11
49
77
10140
|
|
POL
KIIRDYGKQMA
1019
11
49
77
10141
|
|
POL
ESIVIWGK
570
8
50
79
111142
|
|
POL
YVDGAANR
633
8
50
78
0.0003
10143
|
|
POL
LAGRWPVK
856
8
50
78
10144
|
|
POL
KIIRDYGK
1019
8
50
78
10145
|
|
POL
KLAGRWPVK
855
9
50
78
2.7000
10146
|
|
POL
GMDGPKVK
201
11
51
80
0.0007
10147
|
|
POL
KIGPENPY
238
8
51
80
10148
|
|
POL
FTTPDKKII
403
8
51
80
10149
|
|
POL
TFYVDGAA
631
8
51
80
10150
|
|
POL
IITDNGSNF
866
8
51
80
10151
|
|
POL
PGMDGPKVK
200
9
51
80
0.0004
10152
|
|
POL
GFTTPDKKII
402
9
51
80
10153
|
|
POL
ETFYVDGAA
630
9
51
80
10154
|
|
POL
VLFLDGIDK
751
9
51
80
0.0380
10155
|
|
POL
VIYQYMDDLY
368
10
51
80
0.0007
10156
|
|
POL
WGFTTPDKKH
401
10
51
80
10157
|
|
POL
FTTPDKKHQK
403
10
51
80
0.0002
10158
|
|
POL
VLFLDGIDKA
751
10
51
80
0.0004
10159
|
|
POL
KSVTVLDVGD
293
11
51
80
10160
|
|
POL
GFTTPDKKIIQ
402
11
51
80
10161
|
|
POL
QATWIPEWEF
599
10
52
83
0.0004
10162
|
|
POL
PAGLKKKK
286
8
52
81
10163
|
|
POL
SDLEIGQH
380
8
52
81
10164
|
|
POL
DLEIGQHR
381
8
52
81
10165
|
|
POL
WGFTTPDK
401
8
52
81
10166
|
|
POL
GFTTPDKK
402
8
52
81
10167
|
|
POL
KCQLKGEA
794
8
52
81
10168
|
|
POL
VASGYIEA
831
8
52
81
10169
|
|
POL
KIQNFRVY
971
8
52
81
10170
|
|
POL
KVVPRRKA
1011
8
52
81
10171
|
|
POL
VVPRRKAK
1012
8
52
81
0.0027
10172
|
|
POL
ETPGIRYQY
327
9
52
81
10173
|
|
POL
GSDLEIGQH
379
9
52
81
10174
|
|
POL
SDLEIGQHR
380
9
52
81
0.0003
10175
|
|
POL
WGFTTPDKK
401
9
52
81
0.0004
10176
|
|
POL
ATWIPEWEF
600
9
52
81
10177
|
|
POL
IIVASGYIEA
830
9
52
81
0.0003
10178
|
|
POL
KIQNFRVYY
971
9
52
81
0.1200
10179
|
|
POL
KVVPRRKAK
1011
9
52
81
0.0290
10180
|
|
POL
VGSDLEIGQH
378
10
52
81
10181
|
|
POL
GSDLEIGQIIR
379
10
52
81
10182
|
|
POL
KIQNFRVYYR
971
10
52
81
0.0320
10183
|
|
POL
NFRVYYRDSR
974
10
52
81
10184
|
|
POL
IGGIGGFIKVR
134
11
52
81
10185
|
|
POL
VGPTPVNIIGR
164
11
52
81
10186
|
|
POL
YVGSDLEIGQII
377
11
52
81
10187
|
|
POL
VGSDLEIGQIIR
378
11
52
81
10188
|
|
POL
AVIIVASGYIEA
828
11
52
81
10189
|
|
POL
SGYIEAEVIPA
833
11
52
81
10190
|
|
POL
GIPIIPAGLKKK
282
11
53
84
10191
|
|
POL
IGGFIKVR
137
8
53
83
10192
|
|
POL
GFIKVRQY
139
8
53
83
10193
|
|
POL
PIETVPVK
190
8
53
83
10194
|
|
POL
ETVPVKLK
192
8
53
83
0.0049
10195
|
|
POL
ELELAENR
489
8
53
83
10196
|
|
POL
QLKGEAMII
796
8
53
83
10197
|
|
POL
ESMNKELK
904
8
53
83
10198
|
|
POL
SMNKELKK
905
8
53
83
10199
|
|
POL
GIGGFIKVR
136
9
53
83
0.0008
10200
|
|
POL
GGFIKVRQY
138
9
53
83
0.0004
10201
|
|
POL
YIEAEVIPA
835
9
53
83
0.0003
10202
|
|
POL
ESMNKELKK
904
9
53
83
10203
|
|
POL
GGIGGFIKVR
135
10
53
83
0.0004
10204
|
|
POL
IGGFIKVRQY
137
10
53
83
0.0004
10205
|
|
POL
ISPIETVPVK
188
10
53
83
0.0003
10206
|
|
POL
PIETVPVKLK
190
10
53
83
0.0002
10207
|
|
POL
EAELELAENR
487
10
53
83
10208
|
|
POL
LYAVIIVASGY
826
10
53
83
10209
|
|
POL
GIGGFIKVRQY
136
11
53
83
10210
|
|
POL
PISPIETVPVK
187
11
53
83
10211
|
|
POL
ILVAVHVASGY
825
11
53
83
10212
|
|
POL
FVNTPPLVK
608
9
54
86
0.0120
10213
|
|
POL
GIPIIPAGLKK
282
10
54
86
0.0110
10214
|
|
POL
LGIPHPAGLKK
281
11
54
86
10215
|
|
POL
ILVAVIIVA
825
8
54
84
10216
|
|
POL
PTPVNIIGR
166
9
54
84
0.0008
10217
|
|
POL
PLTEEKIKA
212
9
54
84
10218
|
|
POL
LAENREILK
492
9
54
84
0.0002
10219
|
|
POL
EVQLGIPIIPA
278
10
54
84
10220
|
|
POL
ELAENREILK
491
10
54
84
0.0002
10221
|
|
POL
IEFVNTPPLVK
607
10
54
84
10222
|
|
POL
PLTEEKIK
212
8
55
86
10223
|
|
POL
ETFYVDGA
630
8
55
86
10224
|
|
POL
LFLDGIDK
752
8
55
86
10225
|
|
POL
FLDGIDKA
753
8
55
86
10226
|
|
POL
LFLDGIDKA
752
9
55
86
10227
|
|
POL
QLGIPIIPA
280
8
56
89
10228
|
|
POL
GIPHPAGLK
282
9
56
89
0.2300
10229
|
|
POL
KGGIGGYSA
940
9
56
89
10230
|
|
POL
LGIPHPAGLK
281
10
56
89
0.0370
10231
|
|
POL
QLGIPHPAGLK
280
11
56
89
10232
|
|
POL
LTEEKIKA
213
8
56
88
10233
|
|
POL
VTVLDVGDAY
295
10
56
88
0.0001
10234
|
|
POL
ELKKIIGQVR
909
10
56
88
10235
|
|
POL
DFWEVQLGIPII
275
11
56
88
10236
|
|
POL
SVTVLDVGDA
294
11
56
88
10237
|
|
POL
VTVLDVGDAY
295
11
56
88
10238
|
|
POL
PAETGQETAY
842
11
56
88
10239
|
|
POL
KTAVQMAVFI
925
11
56
88
10240
|
|
POL
TGQETAYF
845
8
57
89
10241
|
|
POL
AIKKKDSTK
251
9
57
89
0.0017
10242
|
|
POL
ELNKRTQDF
268
9
57
89
10243
|
|
POL
VTVLDVGDA
295
9
57
89
10244
|
|
POL
TVLDVGDAY
296
9
57
89
0.0002
10245
|
|
POL
TTPDKKIIQK
404
9
57
89
0.0002
10246
|
|
POL
ETGQETAYF
844
9
57
89
10247
|
|
POL
IILKTAVQMA
923
9
57
89
0.0003
10248
|
|
POL
KTAVQMAVF
925
9
57
89
0.0003
10249
|
|
POL
FAIKKKDSTK
250
10
57
89
0.0004
10250
|
|
POL
SVTVLDVGDA
294
10
57
89
10251
|
|
POL
TVLDVGDAYF
296
10
57
89
0.0004
10252
|
|
POL
NTPPLVKLWY
610
10
57
89
0.0002
10253
|
|
POL
AIKKKDSTKW
251
11
57
89
10254
|
|
POL
IILKTAVQMAV
923
11
57
89
10255
|
|
POL
MAVFIIINFKR
930
11
57
89
10256
|
|
POL
GGIGGYSAGER
941
11
57
89
10257
|
|
POL
NLKTGKYA
540
8
58
92
10258
|
|
POL
VLPQGWKGSP
337
11
58
92
10259
|
|
POL
KDSTKWRK
255
8
58
91
10260
|
|
POL
EVQLGIPII
278
8
58
91
10261
|
|
POL
TVLDVGDA
296
8
58
91
10262
|
|
POL
YALGIIQA
693
8
58
91
10263
|
|
POL
GGNEQVDK
735
8
58
91
10264
|
|
POL
FIHNFKRK
933
8
58
91
10265
|
|
POL
GGYSAGER
944
8
58
91
10266
|
|
POL
RVYYRDSR
976
8
58
91
10267
|
|
POL
IGGNEQVDK
734
9
58
91
0.0004
10268
|
|
POL
PAETGQETA
842
9
58
91
10269
|
|
POL
VFIHNFKRK
932
9
58
91
0.0004
10270
|
|
POL
IGGYSAGER
943
9
58
91
0.0004
10271
|
|
POL
STKWRKLVDF
257
10
58
91
0.0003
111272
|
|
POL
GIGGNEQVDK
733
10
58
91
0.0005
10273
|
|
POL
PAETGQETAY
842
10
58
91
10274
|
|
POL
AVFIHNFKRK
931
10
58
91
0.6600
10275
|
|
POL
GIGGYSAGER
942
10
58
91
0.0003
10276
|
|
POL
DSTKWRKLVD
256
11
58
91
10277
|
|
POL
STKWRKLVDF
257
11
58
91
10278
|
|
POL
DSQYALGIIQA
690
11
58
91
10279
|
|
POL
KGIGGNEQVDK
732
11
58
91
10280
|
|
POL
VIPAETGQETA
840
11
58
91
10281
|
|
POL
QGWKGSPA
340
8
59
92
10282
|
|
POL
AVIIVASGY
828
8
59
92
10283
|
|
POL
ETGQETAY
844
8
59
92
10284
|
|
POL
QAFIILKTA
920
8
59
92
10285
|
|
POL
GGIGGYSA
941
8
59
92
10286
|
|
POL
GIWQLDCTII
811
9
59
92
10287
|
|
POL
VAVIIVASGY
827
9
59
92
0.0004
10288
|
|
POL
KGPAKLLWK
988
9
59
92
0.0021
10289
|
|
POL
QGWKGSPAIF
340
10
59
92
0.0004
10290
|
|
POL
EVNIVTDSQY
684
10
59
92
10291
|
|
POL
PGIWQLDCTII
810
10
59
92
10292
|
|
POL
TAVQMAVFIII
926
10
59
92
0.0004
10293
|
|
POL
VGKLNWASQI
450
11
59
92
10294
|
|
POL
EVNIVTDSQYA
684
11
59
92
10295
|
|
POL
NFKRKGGIGGY
936
11
59
92
10296
|
|
POL
PAKLLWKGEG
990
11
59
92
10297
|
|
POL
QLDCTIILEGK
814
10
60
95
0.0010
10298
|
|
POL
DFRELNKR
265
8
60
94
10299
|
|
POL
VLDVGDAY
297
8
60
94
10300
|
|
POL
MAVFIIINF
930
8
60
94
10301
|
|
POL
VDFRELNKR
264
9
60
94
10302
|
|
POL
VLDVGDAYF
297
9
60
94
10303
|
|
POL
MGYELIIPDK
419
9
60
94
0.0640
10304
|
|
POL
KLNWASQIY
452
9
60
94
0.1200
10305
|
|
POL
AVQMAVFIII
927
9
60
94
10306
|
|
POL
QMAVFIHNF
929
9
60
94
0.0010
10307
|
|
POL
MAVFIHNFK
930
9
60
94
0.0170
10308
|
|
POL
KLLWKGEGA
992
9
60
94
0.0003
10309
|
|
POL
LVDFRELNKR
263
10
60
94
10310
|
|
POL
WMGYELHPDK
418
10
60
94
0.0005
10311
|
|
POL
QMAVFIIINFK
929
10
60
94
0.6100
10312
|
|
POL
MAVFIIINFKR
930
10
60
94
0.0068
10313
|
|
POL
KLVDFRELNK
262
11
60
94
10314
|
|
POL
PDKKHQKEPPF
406
11
60
94
10315
|
|
POL
AVQMAVFIHN
927
11
60
94
10316
|
|
POL
QMAVFIHNFK
929
11
60
94
10317
|
|
POL
EALLDTGA
108
8
61
95
10318
|
|
POL
LDVGDAYF
298
8
61
95
10319
|
|
POL
LVGKLNWA
449
8
61
95
10320
|
|
POL
IVTDSQYA
687
8
61
95
10321
|
|
POL
TAVQMAVF
926
8
61
95
10322
|
|
POL
NDIQKLVGK
444
9
61
95
10323
|
|
POL
KLVGKLNWA
448
9
61
95
0.0003
10324
|
|
POL
NIVTDSQYA
686
9
61
95
10325
|
|
POL
LDCTIILEGK
815
9
61
95
10326
|
|
POL
TVNDIQKLVGK
442
11
61
95
0.0400
10327
|
|
POL
MIGGIGGF
133
8
62
97
10328
|
|
POL
VDFRELNK
264
8
62
97
10329
|
|
POL
WTVNDIQK
441
8
62
97
0.0003
10330
|
|
POL
DIQKLVGK
445
8
62
97
10331
|
|
POL
NIVTDSQY
686
8
62
97
10332
|
|
POL
DCIIILEGK
816
8
62
97
10333
|
|
POL
AVFIIINFK
931
8
62
97
0.0280
10334
|
|
POL
VFIHNFKR
932
8
62
97
10335
|
|
POL
LLWKGEGA
993
8
62
97
10336
|
|
POL
KMIGGIGGF
132
9
62
97
0.0004
10337
|
|
POL
LVDFRELNK
263
9
62
97
0.0110
10338
|
|
POL
AVFIIINFKR
931
9
62
97
0.1700
10339
|
|
POL
MIGGIGGFIK
133
10
62
97
0.0099
10340
|
|
POL
KLVDFRELNK
262
10
62
97
0.5100
10341
|
|
POL
KMIGGIGGFIK
132
11
62
97
2.3000
10342
|
|
POL
NVLPQGWK
336
8
63
100
0.0003
10343
|
|
POL
IGGIGGFIK
134
9
63
98
0.0004
10344
|
|
POL
GGIGGFIK
135
8
64
100
10345
|
|
POL
FLWMGYELII
416
9
64
100
10346
|
|
POL
PFLWMGYELII
415
10
64
100
10347
|
|
REV
GTRQTRKNR
37
9
01
50
10348
|
|
REV
TTRQARRNR
37
9
01
50
10349
|
|
REV
GTRQTRKNRR
37
10
01
50
10350
|
|
REV
TTRQARRNRR
37
10
01
50
10351
|
|
REV
GTRQTRKNRR
37
11
01
50
10352
|
|
REV
TTRQARRNRR
37
11
01
50
10353
|
|
REV
GTETGVGR
103
8
06
19
10354
|
|
REV
QGTETGVGR
102
9
06
19
10355
|
|
REV
LLKTVRLIK
12
9
10
16
10356
|
|
REV
GDSDEELLK
6
9
11
17
10357
|
|
REV
PLQLPPIER
76
9
11
17
10358
|
|
REV
SGDSDEELLK
5
10
11
17
10359
|
|
REV
RSGDSDEELLK
4
11
11
17
10360
|
|
REV
PVPLQLPPIER
74
11
11
17
10361
|
|
REV
RARQRQIR
50
8
12
19
10362
|
|
REV
DSDEELLK
7
8
12
19
10363
|
|
REV
ILSTCLGR
63
8
12
19
10364
|
|
REV
RILSTCLGR
62
9
12
19
10365
|
|
REV
AVRIIKILY
17
9
13
20
10366
|
|
REV
PSPEGTRQA
31
9
13
20
10367
|
|
REV
QLPPLERLH
78
9
13
20
10368
|
|
REV
PSPEGTRQAR
31
10
13
20
10369
|
|
REV
PSPEGTRQAR
31
11
13
20
10370
|
|
REV
PLQLPPLERLH
76
11
13
20
10371
|
|
REV
GTRQARKNRR
36
11
14
22
10372
|
|
REV
RARQRQIII
50
8
15
24
10373
|
|
REV
GTRQARKNR
36
9
15
23
10374
|
|
REV
GTRQARKNRR
36
10
15
23
10375
|
|
REV
QARKNRRRR
40
9
16
25
10376
|
|
REV
QARKNRRRR
40
11
16
25
10377
|
|
REV
QARKNRRR
40
8
17
27
10378
|
|
REV
IIKILYQSNPY
20
11
18
28
10379
|
|
REV
KILYQSNPY
22
9
26
41
10380
|
|
REV
ILYQSNPY
23
8
27
42
10381
|
|
REV
EGTRQARR
35
8
27
42
10382
|
|
REV
EGTRQARRNR
35
10
27
42
10383
|
|
REV
EGTRQARRNR
35
11
27
42
10384
|
|
REV
GTRQARRNR
36
9
34
53
10385
|
|
REV
GTRQARRNRR
36
10
34
53
10386
|
|
REV
GTRQARRNRR
36
11
34
53
10387
|
|
REV
PVPLQLPPLER
74
11
34
53
10388
|
|
REV
PLQLPPLER
76
9
35
55
10389
|
|
REV
QARRNRRRR
40
11
37
58
10390
|
|
REV
QARRNRRR
40
8
38
59
10391
|
|
REV
QARRNRRRR
40
9
38
59
10392
|
|
TAT
PGGYPRRK
104
8
01
50
10393
|
|
TAT
AGPGGYPRR
102
9
01
50
10394
|
|
TAT
TGPSGQPCH
102
9
01
50
10395
|
|
TAT
ETGPSGQPCII
101
10
01
50
10396
|
|
TAT
KAGPGGYPRR
101
10
01
50
10397
|
|
TAT
AGPGGYPRRK
102
10
01
50
10398
|
|
TAT
KAGPGGYPRR
101
11
01
50
10399
|
|
TAT
GGYPRRKGSC
105
11
01
50
10400
|
|
TAT
PGSQPRTA
17
8
10
16
10401
|
|
TAT
ACTNCYCK
24
8
10
16
10402
|
|
TAT
TACTNCYCK
23
9
10
16
10403
|
|
TAT
YCKKCCFII
29
8
11
17
10404
|
|
TAT
YCKKCCYII
29
8
11
17
10405
|
|
TAT
CFIICQVCF
34
8
11
17
10406
|
|
TAT
VDPRLEPWK
4
9
11
17
10407
|
|
TAT
ACNNCYCKK
24
9
11
17
10408
|
|
TAT
CCFHCQVCF
33
9
11
17
10409
|
|
TAT
PVDPRLEPWK
3
10
11
17
0.0005
10410
|
|
TAT
VDPRLEPWKH
4
10
11
17
10411
|
|
TAT
TACNNCYCKK
23
10
11
17
10412
|
|
TAT
PVDPRLEPWK
3
11
11
17
10413
|
|
TAT
RGDPTGPKES
84
11
11
17
10414
|
|
TAT
GDPTGPKESK
85
11
11
17
10415
|
|
TAT
ESKKKVESK
93
9
12
19
10416
|
|
TAT
GDPTGPKESK
85
10
12
19
10417
|
|
TAT
PTGPKESKKK
88
10
12
19
10418
|
|
TAT
TGPKESKKK
89
9
13
20
10419
|
|
TAT
FLNKGLGISY
41
10
14
22
10420
|
|
TAT
PVDPNLEPWN
3
11
14
22
10421
|
|
TAT
CFLNKGLGISY
40
11
14
22
10422
|
|
TAT
RGDPTGPK
84
8
16
25
10423
|
|
TAT
VDPNLEPWNH
4
10
16
25
10424
|
|
TAT
ACNNCYCK
24
8
17
27
10425
|
|
TAT
TACNNCYCK
23
9
17
27
10426
|
|
TAT
PTGPKESKK
88
9
18
28
10427
|
|
TAT
TGPKESKK
89
8
19
30
10428
|
|
TAT
PTGPKESK
88
8
20
31
10429
|
|
TAT
YGRKKRRQRR
50
11
22
34
10430
|
|
TAT
PGSQPKTA
17
8
26
41
10431
|
|
TAT
YGRKKRRQRR
50
10
38
59
10432
|
|
TAT
ISYGRKKRRQR
48
11
39
61
10433
|
|
TAT
YGRKKRRQR
50
9
41
64
10434
|
|
TAT
GISYGRKKRR
47
10
45
70
0.0003
10435
|
|
TAT
LGISYGRKKRR
46
11
45
70
10436
|
|
TAT
ISYGRKKRR
48
9
46
72
0.0008
10437
|
|
TAT
GLGISYGRKKR
45
11
54
86
10438
|
|
TAT
GLGISYGR
45
8
55
87
10439
|
|
TAT
GLGISYGRK
45
9
55
87
0.0340
10440
|
|
TAT
GLGISYGRKK
45
10
55
87
10441
|
|
TAT
KGLGISYGR
44
9
55
86
0.0006
10442
|
|
TAT
KGLGISYGRK
44
10
55
86
0.0100
10443
|
|
TAT
KGLGISYGRKK
44
11
55
86
10444
|
|
TAT
GISYGRKKR
47
9
57
89
0.0008
10445
|
|
TAT
LGISYGRKKR
46
10
57
89
10446
|
|
TAT
LGISYGRK
46
8
58
91
10447
|
|
TAT
GISYGRKK
47
8
58
91
10448
|
|
TAT
ISYGRKKR
48
8
58
91
10449
|
|
TAT
LGISYGRKK
46
9
58
91
0.0004
10450
|
|
VIF
LIVWQVDR
8
8
10
16
10451
|
|
VIF
RMRINTWK
15
8
10
16
10452
|
|
VIF
LIKPKKIK
158
8
10
16
10453
|
|
VIF
KGWFYRIIIIY
36
9
10
16
10154
|
|
VIF
ALIKPKKIK
157
9
10
16
10455
|
|
VIF
VDRMRINTWK
13
10
10
16
10456
|
|
VIF
GVSIEWRLRR
87
10
10
16
10457
|
|
VIF
QVDRMRINTW
12
11
10
16
10458
|
|
VIF
RLVITTYWGL
65
11
10
16
10459
|
|
VIF
QTGERDWHLG
75
11
10
16
10460
|
|
VIF
GVSIEWRLRR
87
11
10
16
10461
|
|
VIF
IDPDLADQLIII
103
11
10
16
10462
|
|
VIF
LVEDRWNKPQ
178
11
10
16
10463
|
|
VIF
YSTQIDPDLA
99
10
11
17
10464
|
|
VIF
YSTQVDPGLA
99
10
11
17
10465
|
|
VIF
SIEWKLRR
89
8
11
17
10466
|
|
VIF
TALIKPKK
156
8
11
17
10467
|
|
VIF
LVEDRWNK
178
8
11
17
10468
|
|
VIF
VSIEWRLRR
88
9
11
17
10469
|
|
VIF
SIEWRLRRY
89
9
11
17
10470
|
|
VIF
STQVDPGLA
100
9
11
17
10471
|
|
VIF
SLQYLALKA
149
9
11
17
10472
|
|
VIF
LTALIKPKK
155
9
11
17
10473
|
|
VIF
KLVEDRWNK
177
9
11
17
10474
|
|
VIF
VSIEWRLRRY
88
10
11
17
10475
|
|
VIF
GLADQLIHMH
106
10
11
17
10476
|
|
VIF
IVSPRCEYQA
133
10
11
17
10477
|
|
VIF
GSLQYLALKA
148
10
11
17
10478
|
|
VIF
ALTALIKPKK
154
10
11
17
10479
|
|
VIF
PGLADQLIHMH
105
11
11
17
10480
|
|
VIF
GLADQLIHMH
106
11
11
17
10481
|
|
VIF
VGSLQYLALK
147
11
11
17
10482
|
|
VIF
LALTALIKPKK
153
11
11
17
10483
|
|
VIF
WPYRIIHYESR
38
11
12
19
10484
|
|
VIF
KGWFYRIIII
36
8
12
19
10485
|
|
VIF
WGLQTGER
72
8
12
19
10486
|
|
VIF
QTGERDWH
75
8
12
19
10487
|
|
VIF
SDSAIRKA
121
8
12
19
10488
|
|
VIF
SLQYLALA
149
8
12
19
10489
|
|
VIF
IVWQVDRMK
9
9
12
19
10490
|
|
VIF
STQIDPDLA
100
9
12
19
10491
|
|
VIF
FSDSAIRKA
120
9
12
19
10492
|
|
VIF
FSESAIRNA
120
9
12
19
10493
|
|
VIF
GSLQYLALA
148
9
12
19
10494
|
|
VIF
SLQYLALAA
149
9
12
19
10495
|
|
VIF
KIRTWNSLVK
17
10
12
19
10496
|
|
VIF
LVKIIIIMYVSK
24
10
12
19
10497
|
|
VIF
GLQTGERDWII
73
10
12
19
10498
|
|
VIF
TGERDWIILGII
77
10
12
19
10499
|
|
VIF
IIGVSIEWRLR
86
10
12
19
10500
|
|
VIF
CFSDSAIRKA
119
10
12
19
10501
|
|
VIF
CFSLSAIRNA
119
10
12
19
10502
|
|
VIF
VGSLQYLALA
147
10
12
19
10503
|
|
VIF
GSLQYLALAA
148
10
12
19
10504
|
|
VIF
IVWQVDRMKI
9
11
12
19
10505
|
|
VIF
KIRTWNSLVK
17
11
12
19
10506
|
|
VIF
SLVKIIIIMYVS
23
11
12
19
10507
|
|
VIF
LVKHIIMYVSK
24
11
12
19
10508
|
|
VIF
WGLQTGERD
72
11
12
19
10509
|
|
VIF
DCFSESAIRKA
118
11
12
19
10510
|
|
VIF
DCFSESAIRNA
118
11
12
19
10511
|
|
VIF
KVGSLQYLAL
146
11
12
19
10512
|
|
VIF
VGSLQYLALA
147
11
12
19
10513
|
|
VIF
WFYRIIHYESR
38
10
13
21
10514
|
|
VIF
QVDRMKIR
12
8
13
20
10515
|
|
VIF
IIMYVSKKA
28
8
13
20
10516
|
|
VIF
HIPLGDAR
56
8
13
20
10517
|
|
VIF
ADQLIHMH
108
8
13
20
10518
|
|
VIF
CPSDSAIR
119
8
13
20
10519
|
|
VIF
PSDSAIRK
120
8
13
20
10520
|
|
VIF
SLQYLALK
149
8
13
20
10521
|
|
VIF
LTALIKPK
155
8
13
20
10522
|
|
VIF
LADQLIHMH
107
9
13
20
10523
|
|
VIF
ADQLIHMHY
108
9
13
20
10524
|
|
VIF
CFSDSAIRK
119
9
13
20
10525
|
|
VIF
PSESAIRKA
120
9
13
20
10526
|
|
VIF
GSLQYLALK
148
9
13
20
10527
|
|
VIF
ALTALIKPK
154
9
13
20
10528
|
|
VIF
SVKKLTEDR
174
9
13
20
10529
|
|
VIF
EVHIPLGDAR
54
10
13
20
10530
|
|
VIF
LADQLIHMHY
107
10
13
20
10531
|
|
VIF
ADQLIIIMIIYF
108
10
13
20
10532
|
|
VIF
DCPSESAIRK
118
10
13
20
10533
|
|
VIF
CPSESAIRKA
119
10
13
20
10534
|
|
VIF
VGSLQYLALK
147
10
13
20
10535
|
|
VIF
LALTALIKPK
153
10
13
20
10536
|
|
VIF
PSVKKLTEDR
173
10
13
20
10537
|
|
VIF
LADQLIIIMHYF
107
11
13
20
10538
|
|
VIF
QLIIILYYPDCF
110
11
13
20
10539
|
|
VIF
FDCFSESAIRK
117
11
13
20
10540
|
|
VIF
YLALTALIKPK
152
11
13
20
10541
|
|
VIF
QLIIILYYF
110
8
14
22
10542
|
|
VIF
QLIIIMIIYF
110
8
14
22
10543
|
|
VIF
FSESAIRK
120
8
14
22
10544
|
|
VIF
IVSPRCEY
133
8
14
22
10545
|
|
VIF
GVSIEWRLR
87
9
14
22
10546
|
|
VIF
ADQLIIILYY
108
9
14
22
10547
|
|
VIF
CFSESAIRK
119
9
14
22
10548
|
|
VIF
VDRMRIRTWK
13
10
14
22
10549
|
|
VIF
LADQLIHLYY
107
10
14
22
10550
|
|
VIF
ADQLIIILYYF
108
10
14
22
10551
|
|
VIF
RCDYQAGIINK
137
10
14
22
10552
|
|
VIF
QVDRMRIRTW
12
11
14
22
10553
|
|
VIF
RIRTWNSLVK
17
11
14
22
10554
|
|
VIF
LADQLIHLYYF
107
11
14
22
10555
|
|
VIF
QLIIIMIIYFDCF
110
11
14
22
10556
|
|
VIF
RMRIRTWK
15
8
15
23
10557
|
|
VIF
RTWKSLVK
19
8
15
23
10558
|
|
VIF
VSIEWRLR
88
8
15
23
10559
|
|
VIF
ADQLIIILY
108
8
15
23
10560
|
|
VIF
IIMIIYFDCF
113
8
15
23
10561
|
|
VIF
RTWKSLVKII
19
9
15
23
10562
|
|
VIF
QGVSIEWRK
86
9
15
23
10563
|
|
VIF
LADQLIHLY
107
9
15
23
10564
|
|
VIF
AIRKAILGH
124
9
15
23
10565
|
|
VIF
CDYQAGHNK
138
9
15
23
10566
|
|
VIF
RIRTWKSLVK
17
10
15
23
10567
|
|
VIF
RIRTWNSLVK
17
10
15
23
10568
|
|
VIF
RTWKSLVKHH
19
10
15
23
10569
|
|
VIF
LIIIMIIYFDCF
111
10
15
23
10570
|
|
VIF
SAIRKAILGII
123
10
15
23
10571
|
|
VIF
RIRTWKSLVK
17
11
15
23
10572
|
|
VIF
LGQGVSIEWR
84
11
15
23
10573
|
|
VIF
VDPGLADQLIII
103
11
15
23
10574
|
|
VIF
ITTYWGLH
68
8
16
25
10575
|
|
VIF
GVSIEWRK
87
8
16
25
10576
|
|
VIF
IILYYFDCF
113
8
16
25
10577
|
|
VIF
RCDYQAGH
137
8
16
25
10578
|
|
VIF
LALTALIK
153
8
16
25
10579
|
|
VIF
VITTYWGLH
67
9
16
25
10580
|
|
VIF
YLALTALIK
152
9
16
25
10581
|
|
VIF
KTKGHRGSH
188
9
16
25
0.0004
10582
|
|
VIF
LVITTYWGLH
66
10
16
25
10583
|
|
VIF
LIIILYYFDCF
111
10
16
25
10584
|
|
VIF
EDRWNKPQKT
180
11
17
27
10585
|
|
VIF
KSLVKHHMY
22
9
18
28
10586
|
|
VIF
EDRWNKPQKT
180
11
18
28
10587
|
|
VIF
RCEYQAGIINK
137
10
19
30
10588
|
|
VIF
IIIPLGEAR
56
8
20
31
10589
|
|
VIF
EVIIIPLGEAR
54
10
20
31
10590
|
|
VIF
IITGERDWH
75
8
21
33
10591
|
|
VIF
DLADQLIII
106
8
21
33
10592
|
|
VIF
PDLADQLIII
105
9
21
33
10593
|
|
VIF
VSPRCEYQA
134
9
21
33
10594
|
|
VIF
GLHTGERDWH
73
10
21
33
10595
|
|
VIF
WGLIITGERD
72
11
21
33
10596
|
|
VIF
VSPRCEYQAG
134
11
21
33
10597
|
|
VIF
LTEDRWNKPQ
178
11
21
33
0.0390
10598
|
|
VIF
GSIITMNGH
194
8
22
34
10599
|
|
VIF
RGSHTMNGH
193
9
22
34
10600
|
|
VIF
TTYWGLHTGE
69
11
22
34
10601
|
|
VIF
HLGIIGVSIEW
83
11
22
34
10602
|
|
VIF
SSEVIIIPLGDA
52
11
23
36
10603
|
|
VIF
NSLVKIIIIMY
22
9
24
38
10604
|
|
VIF
EVIIIPLGDA
54
9
24
38
10605
|
|
VIF
QGVSIEWR
86
8
25
39
10606
|
|
VIF
EVHIPLGIEA
54
9
25
39
10607
|
|
VIF
LGQGVSIEWR
84
10
25
39
10608
|
|
VIF
SSEVHIPLGEA
52
11
25
39
10609
|
|
VIF
IILGQGVSIEW
83
11
25
39
10610
|
|
VIF
RCEYQAGII
137
8
26
41
10611
|
|
VIF
RTWNSLVKH
19
9
26
41
10612
|
|
VIF
RTWNSLVKHH
19
10
26
41
10613
|
|
VIF
RTWNSLVK
19
8
27
42
10614
|
|
VIF
IIGVSIEWR
86
8
27
42
10615
|
|
VIF
GLADQLIII
106
8
27
42
10616
|
|
VIF
PGLADQLIH
105
9
27
42
10617
|
|
VIF
LGHGVSIEWR
84
10
27
42
10618
|
|
VIF
YFDCFSESAIR
116
11
27
42
10619
|
|
VIF
WGLHTGER
72
8
28
44
10620
|
|
VIF
YPDCFSESA
116
9
28
44
10621
|
|
VIF
DCFSESAIR
118
9
28
44
10622
|
|
VIF
FDCFSESAIR
117
10
28
44
10623
|
|
VIF
FDCFSESA
117
8
29
45
10624
|
|
VIF
CFSESAIR
119
8
29
4S
10625
|
|
VIF
KLTEDRWNK
177
9
29
45
0.0130
10626
|
|
VIF
VGSLQYLALT
147
11
30
47
10627
|
|
VIF
LTEDRWNK
178
8
31
48
0.0003
10628
|
|
VIF
SLQYLALTA
149
9
31
48
10629
|
|
VIF
GSLQYLALTA
148
10
31
48
10630
|
|
VIF
IVWQVDRMRI
9
11
33
S2
10631
|
|
VIF
QVDRMRIR
32
8
34
53
10632
|
|
VIF
EDRWNKPQK
180
9
39
61
10633
|
|
VIF
VMIVWQVDR
7
11
41
64
10634
|
|
VIF
QVMIVWQVDR
6
10
43
67
10635
|
|
VIF
MIVWQVDRM
8
10
43
67
0.0062
10636
|
|
VIF
AGIINKVGSLQ
142
11
43
67
10637
|
|
VIF
SLYKIIIIMY
23
8
44
69
10638
|
|
VIF
VMIVWQVDR
7
9
44
69
0.0034
10639
|
|
VIF
MIVWQVDR
8
8
46
72
10640
|
|
VIF
IVWQVDRMR
9
9
47
73
0.0008
10641
|
|
VIF
KVGSLQYLA
146
9
52
81
0.0036
10642
|
|
VIF
VGSLQYLA
147
8
58
91
10643
|
|
VPR
LPGRRGR
85
8
01
50
10644
|
|
VPR
NIRGRRVR
85
8
01
50
10645
|
|
VPR
#LPGRRGRNG
85
11
01
50
10646
|
|
VPR
WALELLEELK
18
10
09
15
10647
|
|
VPR
QLLFVIIFR
66
8
10
16
10648
|
|
VPR
HSRIGIIR
79
8
10
16
10649
|
|
VPR
RIGITRQR
81
8
10
16
10650
|
|
VPR
IGITRQRR
82
8
10
16
10651
|
|
VPR
ALELLEELK
19
9
10
16
10652
|
|
VPR
RIGITRQRR
81
9
10
16
10653
|
|
VPR
IISRIGITRQR
79
10
10
16
10654
|
|
VPR
HSRIGITRQRR
79
11
10
16
10655
|
|
VPR
WLHGLGQY
38
8
11
17
10656
|
|
VPR
HFRIGCRH
71
8
11
17
10657
|
|
VPR
HSRIGITR
79
8
11
17
10658
|
|
VPR
FIHFRIGCR
69
9
11
17
10659
|
|
VPR
LPIIIFRIGCR
68
10
11
17
10660
|
|
VPR
PIIIFRIGCRH
69
10
11
17
10661
|
|
VPR
PVIIFRIGCQII
69
10
11
17
10662
|
|
VPR
HFRIGCRIISR
71
10
11
17
10663
|
|
VPR
LLPIIIFRIGCR
67
11
11
37
10664
|
|
VPR
LFIHFRIGCRII
68
11
11
17
10665
|
|
VPR
LFVIIFRIGCQII
68
11
11
17
10666
|
|
VPR
RIGCRIISR
74
8
12
19
10667
|
|
VPR
LGQHIYNTY
42
9
13
20
10668
|
|
VPR
LGQYIYETY
42
9
13
20
10669
|
|
VPR
HFPRIWLH
33
8
14
22
10670
|
|
VPR
KSEAVRHFPR
27
10
14
22
10671
|
|
VPR
AVRHFPRIWL
30
11
14
22
10672
|
|
VPR
KSEAVRHF
27
8
15
23
10673
|
|
VPR
ELKSEAVRHF
25
10
15
23
10674
|
|
VPR
ELKSEAVR
25
8
16
25
10675
|
|
VPR
ETYGDTWA
48
8
16
25
10676
|
|
VPR
DTWAGVEA
52
8
16
25
10677
|
|
VPR
AGVEAIIR
55
8
16
25
10678
|
|
VPR
LLEELKSEA
22
9
16
25
10679
|
|
VPR
ELKSEAVRH
25
9
16
25
10680
|
|
VPR
GDTWAGVEA
51
9
16
25
10681
|
|
VPR
WAGVEAIIR
54
9
16
25
10682
|
|
VPR
ELLEELKNEA
21
10
16
25
10683
|
|
VPR
ELLEELKSEA
21
10
16
25
10684
|
|
VPR
YGDTWAGVEA
50
10
16
25
10685
|
|
VPR
LLIEELKSEAVR
22
11
16
25
10686
|
|
VPR
DTWAGVEAIIR
52
11
16
25
10687
|
|
VPR
ELKNEAVR
25
8
17
27
10688
|
|
VPR
LLEELKNEA
22
9
17
27
10689
|
|
VPR
ELKNEAVRH
25
9
17
27
10690
|
|
VPR
LGQIIIYETY
42
9
17
27
10691
|
|
VPR
ELKNEAVRIIF
25
10
17
27
10692
|
|
VPR
LLELLKNIEAVR
22
11
17
27
10693
|
|
VPR
EGVEAIIR
55
8
18
28
10694
|
|
VPR
DTWEGVEAIIR
52
11
18
28
10695
|
|
VPR
RARNGASR
93
8
19
30
10696
|
|
VPR
WLHCLGQII
38
8
20
31
10697
|
|
VPR
IIGLGQIIIY
40
8
20
31
10698
|
|
VPR
WLIIGLGQIIIY
38
10
20
31
10699
|
|
VPR
DTWEGVEA
52
8
23
36
10700
|
|
VPR
GDTWEGVEA
51
9
23
36
10701
|
|
VPR
YGDTWIEGVEA
50
10
23
36
10702
|
|
VPR
LFIIIFRIGCQII
68
11
29
45
10703
|
|
VPR
FIIIFRIGCQII
69
10
30
47
10704
|
|
VPR
IIFPRPWLH
33
8
31
49
10705
|
|
VPR
AVRHFPRPWL
30
11
31
48
10706
|
|
VPR
RILQQLLFIIIF
62
11
34
53
10707
|
|
VPR
ILQQLLFIIIF
63
10
35
55
0.0130
10708
|
|
VPR
ILQQLLFIIIFR
63
11
35
55
10709
|
|
VPR
RILQQLLFIII
62
10
36
56
10710
|
|
VPR
ILQQLLFIII
63
9
37
58
10711
|
|
VPR
EDQGPQREPY
6
10
37
58
10712
|
|
VPR
AIIRILQQLLF
59
11
38
59
10713
|
|
VPR
QAPEDQGPQR
3
10
39
62
10714
|
|
VPR
IIRILQQLLF
60
10
41
64
10715
|
|
VPR
WTLELLEELK
18
10
42
69
10716
|
|
VPR
QGPQREPY
8
8
43
68
10717
|
|
VPR
QLLFIIIFR
66
8
44
69
10718
|
|
VPR
HFRIGCQII
71
8
44
69
10719
|
|
VPR
TLELLEELK
19
9
44
69
10720
|
|
VPR
HFRIGCQIISR
71
10
44
69
10721
|
|
VPR
RILQQLLF
62
8
45
70
10722
|
|
VPR
RIGCQHSR
74
8
47
73
10723
|
|
VPR
EAVRIIFPR
29
8
59
92
10724
|
|
VPU
IDYRLGVGA
9
9
01
33
10725
|
|
VPU
VOYRIVIVA
9
9
01
33
10726
|
|
VPU
VDYRLGVGA
9
9
01
33
10727
|
|
VPU
KVDYRIVIVA
7
10
01
33
10728
|
|
VPU
KVDYRLGVGA
7
10
01
33
10729
|
|
VPU
RIDYRLGVGA
7
10
01
33
10730
|
|
VPU
VDYRIVIVAF
9
10
01
33
10731
|
|
VPU
KVDYRIVIVAF
7
11
01
33
10732
|
|
VPU
LVQRKQDR
43
8
01
50
10733
|
|
VPU
GVEMGHHA
91
8
01
50
10734
|
|
VPU
VTLLSSSK
94
8
01
50
10735
|
|
VPU
LVQRKQDKR
43
9
01
50
10736
|
|
VPU
LVTLLSSSK
91
9
01
50
10737
|
|
VPU
RIKEIRDDSDY
64
11
01
50
10738
|
|
VPU
RIREIRDDSDY
64
11
01
50
10739
|
|
VPU
LAIVALVVA
13
9
09
15
10740
|
|
VPU
WTIVFIEYR
34
9
10
16
10741
|
|
VPU
TIVFIEYR
35
8
10
16
10742
|
|
VPU
IDRLIDRIR
54
9
10
16
10743
|
|
VPU
RLIDRIRER
56
9
10
16
10744
|
|
VPU
KIDRLIORIR
52
10
10
16
10745
|
|
VPU
VVWTIVFIEYR
31
11
10
16
10746
|
|
VPU
ESEGDQEELSA
75
11
10
16
10747
|
|
VPU
EGDQEELSA
77
9
11
17
10748
|
|
VPU
WTIVFIEY
34
8
12
19
10749
|
|
VPU
AIVALYVA
14
8
12
19
10750
|
|
VPU
IVFIEVRK
36
8
12
19
10751
|
|
VPU
IDRIRERA
59
8
12
19
10752
|
|
VPU
LIDRIRIERA
58
9
12
19
10753
|
|
VPU
VVWTIVFIEY
31
10
12
19
10754
|
|
VPU
IVVWTIVFIEY
30
11
12
19
10755
|
|
VPU
GDQEELSA
78
8
14
22
10756
|
|
VPU
LIDRIRER
58
8
14
22
10757
|
|
VPU
AIVVWTIVF
29
9
14
22
10758
|
|
VPU
IVVWTIVF
30
8
15
23
10759
|
|
VPU
KIDRLIDR
52
8
15
23
10760
|
|
VPU
ILRQRKIDR
46
9
15
23
10761
|
|
VPU
KILRQRKIDR
45
10
15
23
0.0039
10762
|
|
TABLE XVII
|
|
|
HIV A11 Motif Peptides with Binding Information
|
No. of
SEQ
|
Amino
Sequence
Conservancy
ID
|
Protein
Sequence
Position
Acids
Frequency
(%)
A*1101
NO.
|
|
ENV
IGPGQTFY
361
8
01
25
10763
|
|
ENV
IGSGQAFY
361
8
01
25
10764
|
|
ENV
GTAGNSSR
375
8
01
33
10765
|
|
ENV
NNTSPRSR
375
8
01
33
10766
|
|
ENV
ADNLWVTVY
42
9
01
33
10767
|
|
ENV
GIGPGQTFY
360
9
01
33
10768
|
|
ENV
SIGSGQAFY
360
9
01
33
10769
|
|
ENV
ADNLWVTVYY
42
10
01
33
10770
|
|
ENV
EGKNEINDTY
217
10
01
33
10771
|
|
ENV
NTSPRSRVAY
376
10
01
33
10772
|
|
ENV
TAGNSSRAAY
376
10
01
33
10773
|
|
ENV
GTAGNSSRAA
375
11
01
33
10774
|
|
ENV
NNTSPRSRVA
375
11
01
33
10775
|
|
ENV
KLREIRQFENK
405
11
01
25
10776
|
|
ENV
KNNTETNK
535
8
01
50
10777
|
|
ENV
IINIIITPII
584
8
01
50
10778
|
|
ENV
VISTRTIIR
584
8
01
50
10779
|
|
ENV
INIIITPHR
585
8
01
50
10780
|
|
ENV
STRTIIREK
586
8
01
50
10781
|
|
ENV
SNNTSPRSR
374
9
01
50
10782
|
|
ENV
NANITIPCR
478
9
01
50
10783
|
|
ENV
IINHTPIIR
584
9
01
50
10784
|
|
ENV
ISTRTIIREK
585
9
01
50
10785
|
|
ENV
NIIITPIIREK
586
9
01
50
10786
|
|
ENV
STRTIIREKR
586
9
01
50
10787
|
|
ENV
VISTRTIIREK
584
10
01
50
10788
|
|
ENV
INIHTPIIREK
585
10
01
50
10789
|
|
ENV
ISTRTHREKR
585
10
01
50
10790
|
|
ENV
NIIITPIIREKR
586
10
01
50
10791
|
|
ENV
IITIEGNITLQCR
478
11
01
50
10792
|
|
ENV
NANITIPCRIK
478
11
01
50
10793
|
|
ENV
GNSTNGTETF
535
11
01
50
10794
|
|
ENV
IINIIITPHREK
584
11
01
50
10795
|
|
ENV
VISTRTHREKR
584
11
01
50
10796
|
|
ENV
INIHTPHREKR
585
11
01
50
10797
|
|
ENV
DSSNSTGNY
218
9
01
20
10798
|
|
ENV
STNGTETFR
537
9
01
17
10799
|
|
ENV
TNSSYTNDTY
458
10
01
17
10800
|
|
ENV
NDTENNTEIFR
537
11
01
17
10801
|
|
ENV
NTETNKTETF
537
11
01
17
10802
|
|
ENV
NTTGNTTETF
537
11
01
17
10803
|
|
ENV
NGSENGTETF
537
11
02
33
10804
|
|
ENV
GSENGTETFR
538
10
02
18
10805
|
|
ENV
NDTITLPCR
477
9
03
20
10806
|
|
ENV
NDTITLPCRIK
477
11
03
20
10807
|
|
ENV
RGWEALKY
895
8
06
19
10808
|
|
ENV
KGLRLGWEGL
891
11
08
27
10809
|
|
ENV
LGWEGLKY
895
8
09
29
10810
|
|
ENV
RLGWEGLKY
894
9
09
29
10811
|
|
ENV
GLRLGWEGLK
892
11
09
29
10812
|
|
ENV
LGRRGWEALK
883
10
09
15
10813
|
|
ENV
LLGRRGWEAL
882
11
09
15
10814
|
|
ENV
RLGWEGLK
894
8
10
32
10815
|
|
ENV
GLRLGWEGLK
892
10
10
32
10816
|
|
ENV
ENLWVTVY
43
8
10
17
10817
|
|
ENV
ENLWVTVYY
43
9
10
17
10818
|
|
ENV
DIIGDIRQAII
372
10
10
16
10819
|
|
ENV
NNTRKSIR
350
8
10
16
10820
|
|
ENV
PLGVAPTR
571
8
10
16
10821
|
|
ENV
DITNWLWY
769
8
10
16
10822
|
|
ENV
DFILIAAR
870
8
10
16
10823
|
|
ENV
STITQACPK
243
9
10
16
10824
|
|
ENV
FDITNWLWY
768
9
10
16
10825
|
|
ENV
RDFILIAAR
869
9
10
16
10826
|
|
ENV
FAILKCNDKK
269
10
10
16
10827
|
|
ENV
MLQLTVWGIK
651
10
10
16
10828
|
|
ENV
RVLAVEKYLR
665
10
10
16
10829
|
|
ENV
WFDITNWLW
767
10
10
16
10830
|
|
ENV
EGIEEEGGER
828
10
10
16
10831
|
|
ENV
GFAILKCNDKK
268
11
10
16
10832
|
|
ENV
GDIIGDIRQAII
371
11
10
11
10833
|
|
ENV
NVPWNSSWSN
693
11
10
16
10834
|
|
ENV
WMEWEREIDN
723
11
10
16
10835
|
|
ENV
IAIAVALGTDR
925
11
10
16
10836
|
|
ENV
RGWEALKY
886
8
11
18
10837
|
|
ENV
KLWVTVYY
44
8
11
17
10838
|
|
ENV
WNSSWSNR
696
8
11
17
10839
|
|
ENV
TITQACPK
244
8
11
17
10840
|
|
ENV
IGPGQTFY
358
8
11
17
10841
|
|
ENV
LAVERYLR
667
8
11
17
10842
|
|
ENV
SNWLWYIK
771
8
11
17
10843
|
|
ENV
NLCLFSYII
859
8
11
17
10844
|
|
ENV
RIGPGQTFY
357
9
11
17
10845
|
|
ENV
ITTHSFNCR
431
9
11
17
10846
|
|
ENV
NITLPCRIK
482
9
11
17
10847
|
|
ENV
VLAVERYLR
666
9
11
17
10848
|
|
ENV
ISNWLWYIK
770
9
11
17
10849
|
|
ENV
RNLCLFSYII
858
9
11
17
10850
|
|
ENV
NLCLFSYHR
859
9
11
17
10851
|
|
ENV
EITTHSFNCR
430
10
11
17
10852
|
|
ENV
RNLCLFSYHR
858
10
11
17
10853
|
|
ENV
YATGDIIGDIR
368
11
11
17
10854
|
|
ENV
DLRNLCLFSYII
856
11
11
17
10855
|
|
ENV
NLCLFSYHRLR
859
11
11
17
10856
|
|
ENV
GNLWVTVY
43
8
12
20
10857
|
|
ENV
GNLWVTVYY
43
9
12
20
10858
|
|
ENV
TGDIIGDIR
370
9
12
19
10859
|
|
ENV
EAQQIILLK
646
8
12
19
10860
|
|
ENV
ILKCNDKK
271
8
12
19
10861
|
|
ENV
TTIISFNCR
432
8
12
19
10862
|
|
ENV
MTWMEWER
721
8
12
19
10863
|
|
ENV
GGERDRDR
834
8
12
19
10864
|
|
ENV
AILKCNDKK
270
9
12
19
10865
|
|
ENV
LAEEEVVIR
312
9
12
19
0.0002
10866
|
|
ENV
INMWQEVGK
493
9
12
19
10867
|
|
ENV
NMTWMEWER
720
9
12
19
10868
|
|
ENV
GIEEEGGER
829
9
12
19
10869
|
|
ENV
EGGERDRDR
833
9
12
19
10870
|
|
ENV
SLAEEEVVIR
311
10
12
19
10871
|
|
ENV
ATGDIIGDIR
369
10
12
19
10872
|
|
ENV
IINMWQEVGK
492
10
12
19
10873
|
|
ENV
AIEAQQHLLK
644
10
12
19
10874
|
|
ENV
LLQYWSQELK
906
10
12
19
10875
|
|
ENV
AILIIIPRRIR
946
10
12
19
10876
|
|
ENV
PTRIRQGLER
951
10
12
19
10877
|
|
ENV
KTTLFCASDA
60
11
12
19
10878
|
|
ENV
GSLAEEEVVIR
310
11
12
19
10879
|
|
ENV
QIINMWQEVG
491
11
12
19
10880
|
|
ENV
KNEQELLELDK
750
11
12
19
10881
|
|
ENV
GIEEEGGERDR
829
11
12
19
10882
|
|
ENV
NLLQYWSQEL
905
11
12
19
10883
|
|
ENV
RAILIIIPRRIR
945
11
12
19
10884
|
|
ENV
SVEINCTR
340
8
13
20
10885
|
|
ENV
GDIIGDIR
371
8
13
20
10886
|
|
ENV
KLTVWGIK
653
8
13
20
10887
|
|
ENV
RAILIIIPR
945
8
13
20
10888
|
|
ENV
AILIIIPRR
946
8
13
20
10889
|
|
ENV
KAKRRVVQR
579
9
13
20
0.0002
10890
|
|
ENV
RAILHIPRR
945
9
13
20
10891
|
|
ENV
ILIIIPRRIR
947
9
13
20
10892
|
|
ENV
TNVSTVQCTH
286
10
13
20
10893
|
|
ENV
SGGDPEIVMH
425
10
13
20
10894
|
|
ENV
LLKLTVWGIK
651
10
13
20
10895
|
|
ENV
NTSVITQACPK
241
11
13
20
10896
|
|
ENV
CTNVSTVQCT
285
11
13
20
10897
|
|
ENV
SSGGDLEITTII
424
11
13
20
10898
|
|
ENV
SSGGDPEIVMH
424
11
13
20
10899
|
|
ENV
PTKAKRRVVQ
576
11
13
20
10900
|
|
ENV
KAKRRVVQRE
579
11
13
20
10901
|
|
ENV
HLLKLTVWGI
650
11
13
20
10902
|
|
ENV
KNEQDLLALD
750
11
13
20
10903
|
|
ENV
TGEIIGDIR
370
9
14
23
10904
|
|
ENV
AITQACPK
244
8
14
22
10905
|
|
ENV
GDPEIVMH
427
8
14
22
10906
|
|
ENV
QDLLALDK
753
8
14
22
10907
|
|
ENV
SAITQACPK
243
9
14
22
10908
|
|
ENV
FAILKCNDK
269
9
14
22
0.0002
10909
|
|
ENV
GGDPEIVMH
426
9
14
22
10910
|
|
ENV
TITLPCRIK
482
9
14
22
10911
|
|
ENV
TSAITQACPK
242
10
14
22
10912
|
|
ENV
TSVITQACPK
242
10
14
22
10913
|
|
ENV
GFAILKCNDK
268
10
14
22
10914
|
|
ENV
IFAVLSIVNR
793
10
14
22
10915
|
|
ENV
NTSAITQACPK
241
11
14
22
10916
|
|
ENV
AGFAILKCNDK
267
11
14
22
10917
|
|
ENV
IIFAVLSIVNR
792
11
14
22
10918
|
|
ENV
KIEPLGVAPTK
568
11
15
24
10919
|
|
ENV
FDPIPIHY
255
8
15
23
10920
|
|
ENV
PAGYAILK
266
8
15
23
10921
|
|
ENV
NMWQEVGK
494
8
15
23
10922
|
|
ENV
TNWLWYIK
771
8
15
23
10923
|
|
ENV
ITNWLWYIK
770
9
15
23
10924
|
|
ENV
SGGDLEITTII
425
10
15
23
10925
|
|
ENV
IFRPGGGDMR
545
10
15
23
10926
|
|
ENV
NMWQEVGKA
494
11
15
23
10927
|
|
ENV
EIFRPGGGDMR
544
11
15
23
10928
|
|
ENV
DDLRNLCLFSY
855
11
15
23
10929
|
|
ENV
FNGTGPCK
279
8
16
25
10930
|
|
ENV
RNLCLFSY
858
8
16
25
10931
|
|
ENV
ITKWLWYIK
770
9
16
25
10932
|
|
ENV
SFNCRGEFFY
437
10
16
25
10933
|
|
ENV
DLRNLCLFSY
856
10
16
25
10934
|
|
ENV
IISFNCRGEFFY
434
11
16
25
10935
|
|
ENV
WNASWSNK
696
8
17
27
10936
|
|
ENV
KAYDTEVII
72
8
17
27
10937
|
|
ENV
VITQACPK
244
8
17
27
10938
|
|
ENV
RVVQREKR
587
8
17
27
0.0001
10939
|
|
ENV
SVITQACPK
243
9
17
27
10940
|
|
ENV
VAPTKAKRR
574
9
17
27
0.0002
10941
|
|
ENV
DAKAYDTEVH
70
10
17
27
10942
|
|
ENY
GVAPTKAKRR
573
10
17
27
10943
|
|
ENV
VFAVLSIVNR
793
10
17
27
10944
|
|
ENV
SDAKAYDTEV
69
11
17
27
10945
|
|
ENV
DTEVIINVWAT
75
11
17
27
10946
|
|
ENV
NCTRPNNNTR
344
11
17
27
10947
|
|
ENV
LGVAPTKAKR
572
11
17
27
10948
|
|
ENV
IVFAVLSIVNR
792
11
17
27
10949
|
|
ENV
WNSSWSNK
696
8
18
29
10950
|
|
ENV
ENVTENFNMW
100
11
18
29
10951
|
|
ENV
VLAVERYLK
666
9
18
28
10952
|
|
ENV
RVLAVERYLK
665
10
18
28
10953
|
|
ENV
NCRGEFFY
439
8
19
30
10954
|
|
ENV
GVAPTKAK
573
8
19
30
10955
|
|
ENV
VAPTKAKR
574
8
19
30
10956
|
|
ENV
FNCRGEFFY
438
9
19
30
10957
|
|
ENV
LGVAPTKAK
572
9
19
30
10958
|
|
ENV
GVAPTKAKR
573
9
19
30
10959
|
|
ENV
PLGVAPTKAK
571
10
19
30
10960
|
|
ENV
LGVAPTKAKR
572
10
19
30
10961
|
|
ENV
SSNITGLLLTR
516
11
19
30
10962
|
|
ENV
PLGVAPTKAK
571
11
19
30
10963
|
|
ENV
AILKCNDK
270
8
20
31
10964
|
|
ENV
ETFRPGGGDM
544
11
20
31
10965
|
|
ENV
LIEESQNQQEK
740
11
20
31
10966
|
|
ENV
GDLEITTII
427
8
21
33
10967
|
|
ENV
GGDLEITTH
426
9
21
33
10968
|
|
ENV
TAIAVAEGTDR
925
11
21
33
10969
|
|
ENV
RIVELLGR
878
8
22
34
10970
|
|
ENV
IVELLGRR
879
8
22
34
10971
|
|
ENV
RIVELLGRR
878
9
22
34
0.0100
10972
|
|
ENV
NCTRPNNNTR
344
10
22
34
10973
|
|
ENV
CTRPNNNTRK
345
10
22
34
10974
|
|
ENV
TTTLFCASDA
60
11
22
34
10975
|
|
ENV
INCTRPNNNTR
343
11
22
34
10976
|
|
ENV
TVQCTIIGIR
290
9
23
36
0.0008
10977
|
|
ENV
STVQCTIIGIR
289
10
23
36
10978
|
|
ENV
VSTVQCTIIGIR
288
11
23
36
10979
|
|
ENV
TFRPGGGDMR
545
10
24
38
10980
|
|
ENV
ALAWDDLR
851
8
25
39
10981
|
|
ENV
LALAWDDLR
850
9
25
39
10982
|
|
ENV
KNVSTVQCTII
286
10
25
39
10983
|
|
ENV
IVQQQNNLLR
634
10
25
39
0.0190
10984
|
|
ENV
FLALAWDDLR
849
10
25
39
10985
|
|
ENV
GIVQQQNNLLR
633
11
25
39
10986
|
|
ENV
GFLALAWDDL
848
11
25
39
10987
|
|
ENV
ITLPCRIK
483
8
26
41
10988
|
|
ENV
PLGVAPTK
571
8
26
41
10989
|
|
ENV
LAVERYLK
667
8
26
41
10990
|
|
ENV
KNNMVEQMH
110
9
26
41
10991
|
|
ENV
IVQQQSNLLR
634
10
26
41
10992
|
|
ENV
GIVQQQSNLLR
633
11
26
41
10993
|
|
ENV
IIGDIRQAH
377
9
27
44
10994
|
|
ENV
ESQNQQEK
743
8
27
42
10995
|
|
ENV
IGDIRQAII
378
8
28
44
10996
|
|
ENV
NNMVEQMII
111
8
28
44
10997
|
|
ENV
TYQCTIIGIK
290
9
28
44
0.0460
10998
|
|
ENV
CTRPNNNTR
345
9
28
44
10999
|
|
ENV
YSFEPIPIHY
253
10
28
44
11000
|
|
ENV
STYQCTIIGIK
289
10
28
44
11001
|
|
ENV
ASITLTVQAR
619
10
28
44
11002
|
|
ENV
KYSFEPIPIHY
252
11
28
44
11003
|
|
ENV
YCAPAGFAILK
263
11
28
44
11004
|
|
ENV
YSTVQCTHGIK
288
11
28
44
11005
|
|
ENV
AASITLTVQAR
618
11
28
44
11006
|
|
ENV
YSFEPIPIII
253
9
29
45
11007
|
|
ENV
KVSFEPIPIH
252
10
29
45
11008
|
|
ENV
CAPAGFAILK
264
10
29
45
11009
|
|
ENV
RSELYKYKVV
558
11
29
45
11010
|
|
ENV
AYLSIVNR
795
8
31
48
11011
|
|
ENV
AYAEGTDR
928
8
31
48
11012
|
|
ENV
VTENFNMWK
102
9
31
48
11013
|
|
ENV
SFEPIPIIIY
254
9
31
48
11014
|
|
ENV
FAVLSIVNR
794
9
31
48
11015
|
|
ENV
SLCLFSYIIR
859
9
31
48
11016
|
|
ENV
IAVAEGTDR
927
9
31
48
0.0003
11017
|
|
ENV
NVTENFNMW
101
10
31
48
11018
|
|
ENV
AVLSIVNRVR
795
10
31
48
11019
|
|
ENV
RSLCLFSYHR
858
10
31
48
11020
|
|
ENV
AIAVAEGTDR
926
10
31
48
11021
|
|
ENV
FAVLSIVNRVR
794
11
31
48
11022
|
|
ENV
DDLRSLCLFSY
855
11
31
48
11023
|
|
ENV
SLCLFSYHRLR
859
11
31
48
11024
|
|
ENV
ELYKYKVVK
560
9
32
51
11025
|
|
ENV
RVVEREKR
587
8
32
50
11026
|
|
ENV
ITLTVQAR
621
8
32
50
11027
|
|
ENV
SLCLFSYII
859
8
32
50
11028
|
|
ENV
SITLTVQAR
620
9
32
50
11029
|
|
ENV
RSLCLFSYII
858
9
32
50
11030
|
|
ENV
DLRSLCLFSYII
856
11
32
50
11031
|
|
ENV
SFEPIPIII
254
8
33
52
11032
|
|
ENV
RVLAVERY
665
8
33
52
11033
|
|
ENV
QARVLAVER
663
9
33
52
0.0003
11034
|
|
ENV
QARVLAVERY
663
10
33
52
11035
|
|
ENV
QLQARVLAVE
661
11
33
52
11036
|
|
ENV
IMIVGGLIGLR
781
11
34
54
11037
|
|
ENV
LLQLTVWGIK
651
10
34
53
0.0110
11038
|
|
ENV
IILLQLTVWGI
650
11
34
53
11039
|
|
ENV
LSIVNRVRQGY
797
11
34
53
11040
|
|
ENV
NLWVTVYY
44
8
35
56
11041
|
|
ENV
NCGGIWFY
439
8
35
55
11042
|
|
ENV
RSLCLFSY
858
8
35
55
11043
|
|
ENV
EVIINVWATII
77
9
35
55
11044
|
|
ENV
FNCGGEFFY
438
9
35
55
11045
|
|
ENV
NITGLLLTR
519
9
35
55
0.0001
11046
|
|
ENV
SFNCGGEFFY
437
10
35
55
11047
|
|
ENV
SNITGLLLTR
517
10
35
55
0.0014
11048
|
|
ENV
DLRSLCLFSY
856
10
35
55
11049
|
|
ENV
HSFNCGGEFFY
434
11
35
55
11050
|
|
ENV
GGGDMRDNW
549
10
36
56
11051
|
|
ENV
MIVGGLIGLR
782
10
36
56
11052
|
|
ENV
SIVNRVRQGY
798
10
36
56
0.0008
11053
|
|
ENV
PGGGDMRDN
548
11
36
56
11054
|
|
ENV
ITGLLLTR
520
8
37
58
11055
|
|
ENV
DMRDNWRSEL
552
11
37
58
11056
|
|
ENV
PAGFAILK
266
8
38
59
11057
|
|
ENV
LSIVNRVR
797
8
38
59
11058
|
|
ENV
VLSIVNRVR
796
9
38
59
11059
|
|
ENV
IVNRVRQGY
799
9
38
59
11060
|
|
ENV
IISLWDQSLK
121
10
38
59
0.0540
11061
|
|
ENV
DIISLWDQSLK
120
11
38
59
11062
|
|
ENV
GDMRDNWR
551
8
39
61
11063
|
|
ENV
GGDMRDNWR
550
9
39
61
11064
|
|
ENV
RDNWRSELY
554
9
40
63
0.0001
11065
|
|
ENV
RDNWRSELYK
554
10
40
63
0.0028
11066
|
|
ENV
TLFCASDAKA
64
11
40
63
11067
|
|
ENV
RDNWRSELYK
554
11
40
63
11068
|
|
ENV
TVYYGVPVWK
48
10
41
64
7.8000
11069
|
|
ENV
VTVYYGVPVW
47
11
41
64
4.1000
11070
|
|
ENV
CASDAKAY
67
8
42
66
11071
|
|
ENV
LCLFSYIIR
860
8
42
66
11072
|
|
ENV
FCASDAKAY
66
9
42
66
11073
|
|
ENV
IVGGLIGLR
783
9
42
66
11074
|
|
ENV
CLFSYIIRLR
861
9
42
66
11075
|
|
ENV
LFCASDAKAY
65
10
42
66
0.0002
11076
|
|
ENV
LCLFSYIIRLR
860
10
42
66
11077
|
|
ENV
VGGLIGLR
784
8
43
67
11078
|
|
ENV
QLTVWGIK
653
8
44
69
11079
|
|
ENV
LFSYIIRLR
862
8
44
69
11080
|
|
ENV
RIRQGLER
953
8
44
69
11081
|
|
ENV
VNRVRQGY
800
8
45
71
11082
|
|
ENV
SLWDQSLK
123
8
47
75
11083
|
|
ENV
ISLWDQSLK
122
9
47
73
0.0890
11084
|
|
ENV
WDQSLKPCVK
125
10
47
73
11085
|
|
ENV
QSLKPCVK
127
8
48
75
11086
|
|
ENV
TVWGIKQLQA
655
11
48
75
11087
|
|
ENV
DNWRSELY
555
8
49
77
11088
|
|
ENV
GIKQLQAR
658
8
49
77
11089
|
|
ENV
DNWRSELYK
555
9
49
77
0.0014
11090
|
|
ENV
WGIKQLQAR
657
9
49
77
0.0001
11091
|
|
ENV
DNWRSELYKY
555
10
49
77
0.0001
11092
|
|
ENV
DNWRSELYKY
555
11
49
77
11093
|
|
ENV
LGIWGCSGK
679
9
50
78
0.0023
11094
|
|
ENV
TTLFCASDAK
61
10
50
78
0.2200
11095
|
|
ENV
LLGIWGCSGK
678
10
50
78
0.0120
11096
|
|
ENV
NLLRAIEAQQH
640
11
50
78
11097
|
|
ENV
QLLGIWGCSG
677
11
50
78
11098
|
|
ENV
VSTVQCTH
288
8
51
80
11099
|
|
ENV
RAIEAQQH
643
8
51
80
11100
|
|
ENV
NVSTVQCTH
287
9
51
80
11101
|
|
ENV
LLRAIEAQQH
641
10
51
80
11102
|
|
ENV
GIWGCSGK
680
8
52
81
11103
|
|
ENV
TLFCASDAK
64
9
52
81
0.5300
11104
|
|
ENV
RSELYKYK
558
8
54
84
11105
|
|
ENV
LFCASDAK
65
8
57
89
11106
|
|
GAG
AAAIMMQK
405
8
01
25
11107
|
|
GAG
SATIMMQR
405
8
01
25
11108
|
|
GAG
KDKDKELY
535
8
01
25
11109
|
|
GAG
ETIDKDLY
537
8
01
25
11110
|
|
GAG
NSATIMMQR
404
9
01
33
11111
|
|
GAG
TAPPPESFR
508
9
01
33
11112
|
|
GAG
NGKQANFLGK
461
10
01
25
11113
|
|
GAG
NGRQANFLGK
461
10
01
25
11114
|
|
GAG
PTAPPPESFR
507
10
01
33
11115
|
|
GAG
NGKQANFLGK
461
11
01
25
11116
|
|
GAG
NGRQANFLGK
461
11
01
25
11117
|
|
GAG
PAAADKEK
123
8
01
50
11118
|
|
GAG
ASAQQDLK
392
8
01
50
11119
|
|
GAG
ATAQQDLK
392
8
01
50
11120
|
|
GAG
AADKGVSQNY
130
10
01
50
11121
|
|
GAG
SAQQDLKGGY
393
10
01
50
11122
|
|
GAG
TAQQDLKGGY
393
10
01
50
11123
|
|
GAG
GTRPGNYVQK
480
10
01
50
11124
|
|
GAG
GTRPGNYVQR
480
10
01
50
11125
|
|
GAG
ITSLPKQEQK
526
10
01
50
11126
|
|
GAG
PAAADKEKDS
123
11
01
50
11127
|
|
GAG
GANSIPVGDIY
276
11
01
50
11128
|
|
GAG
PNQPIPVGDIY
276
11
01
50
11129
|
|
GAG
ASAQQDLKGG
392
11
01
50
11130
|
|
GAG
ATAQQDLKGG
392
11
01
50
11131
|
|
GAG
EITSLPKQEQK
525
11
01
50
11132
|
|
GAG
YTAVFMQR
405
8
02
50
11133
|
|
GAG
TAPPAESFR
508
9
02
67
11134
|
|
GAG
PTAPPAESFR
507
10
02
67
11135
|
|
GAG
EGRQANFLGK
462
10
02
100
11136
|
|
GAG
AADKGKVSQN
129
11
02
18
11137
|
|
GAG
EADGKVSQNY
129
10
04
36
11138
|
|
GAG
AAAIMMQK
400
8
04
19
11139
|
|
GAG
AAIMMQKSNF
406
11
06
15
11140
|
|
GAG
KTVKCFNCGK
421
10
08
16
11141
|
|
GAG
GARASILR
2
8
10
16
11142
|
|
GAG
PGNFPQSR
483
8
10
16
11143
|
|
GAG
MGARASILR
1
9
10
16
11144
|
|
GAG
KIWPSSKGR
472
9
10
16
11145
|
|
GAG
TGNSSQVSQN
139
11
10
16
11146
|
|
GAG
NFLGKIWPSSK
468
11
10
16
11147
|
|
GAG
PVAPGQMR
243
8
10
16
11148
|
|
GAG
MMQKSNFK
409
8
10
16
11149
|
|
GAG
MMQRGNFK
409
8
10
16
11150
|
|
GAG
KLDKWEKIR
12
9
10
16
11151
|
|
GAG
GGKKKYKLK
24
9
10
16
0.0001
11152
|
|
GAG
RDTKEALDK
97
9
10
16
11153
|
|
GAG
IMMQKSNFK
408
9
10
16
11154
|
|
GAG
LGKIWPSSK
470
9
10
16
11155
|
|
GAG
PGGKKKYKLK
23
10
10
16
11156
|
|
GAG
GGKKKYKLKH
24
10
10
16
11157
|
|
GAG
AGPVAPGQMR
241
10
10
16
11158
|
|
GAG
FLGKIWPSSK
469
10
10
16
11159
|
|
GAG
KLDKWEKIRL
12
11
10
16
11160
|
|
GAG
PGGKKKYKLK
23
11
10
16
11161
|
|
GAG
LGKIWPSSKGR
470
11
10
16
11162
|
|
GAG
ATIMMQRGNF
406
11
11
28
11163
|
|
GAG
PSQKQEPIDK
528
10
11
18
11164
|
|
GAG
PIPVGDIY
279
8
11
17
11165
|
|
GAG
TIKCFNCGK
422
9
11
17
11166
|
|
GAG
TVKCFNCGK
422
9
11
17
11167
|
|
GAG
GNSSQVSQNY
140
10
12
23
11168
|
|
GAG
TIMMQRGNFR
407
10
12
21
11169
|
|
GAG
QTGSEELR
71
8
12
19
11170
|
|
GAG
FNCGKEGIIIAR
426
11
12
19
11171
|
|
GAG
PGGKKKYK
23
8
12
19
11172
|
|
GAG
TLYCVIIQK
86
8
12
19
11173
|
|
GAG
DTKEALEK
98
8
12
19
11174
|
|
GAG
MLNIVGGH
208
8
12
19
11175
|
|
GAG
PTSILDIR
303
8
12
19
11176
|
|
GAG
GSEELRSLY
73
9
12
19
11177
|
|
GAG
ATLYCVIIQK
85
9
12
19
11178
|
|
GAG
KDTKEALEK
97
9
12
19
11179
|
|
GAG
MMLNIVGGII
207
9
12
19
11180
|
|
GAG
TGSEELRSLY
72
10
12
19
11181
|
|
GAG
VATLYCVIIQK
84
10
12
19
11182
|
|
GAG
NMMLNIVGGII
206
10
12
19
11183
|
|
GAG
YSPTSILDIR
301
10
12
19
11184
|
|
GAG
RAEQASQEVK
329
10
12
19
11185
|
|
GAG
RLRPGGKKKY
20
11
12
19
11186
|
|
GAG
TVATLYCVIIQ
83
11
12
19
11187
|
|
GAG
LNMMLNIVGG
205
11
12
19
11188
|
|
GAG
SNPPIPVGEIY
273
11
12
19
11189
|
|
GAG
TSILDIRQGPK
304
11
12
19
11190
|
|
GAG
PGNFLQNR
483
8
13
21
11191
|
|
GAG
IARNCRAPR
434
9
13
21
11192
|
|
GAG
KIWPSNKGR
472
9
13
21
11193
|
|
GAG
NCGKEGIIIAR
427
10
13
21
11194
|
|
GAG
IARNCRAPRK
434
10
13
21
11195
|
|
GAG
IARNCRAPRKK
434
11
13
21
11196
|
|
GAG
NFLGKIWPSNK
468
11
13
21
11197
|
|
GAG
KGRPGNFLQN
478
11
13
21
11198
|
|
GAG
RIEVKDTK
93
8
13
20
11199
|
|
GAG
IVKCFNCGK
422
9
13
20
11200
|
|
GAG
CGKEGHIAR
428
9
13
20
11201
|
|
GAG
EGHIARNCR
431
9
13
20
11202
|
|
GAG
LGKIWPSNK
470
9
13
20
11203
|
|
GAG
KLKHIVWASR
31
10
13
20
11204
|
|
GAG
HIARNCRAPR
433
10
13
20
11205
|
|
GAG
FLGKIWPSNK
469
10
13
20
11206
|
|
GAG
EVKDTKEALD
95
11
13
20
11207
|
|
GAG
AAEWDRVHPV
230
11
13
20
11208
|
|
GAG
HIARNCRAPRK
433
11
13
20
11209
|
|
GAG
LGKIWPSNKG
470
11
13
20
11210
|
|
GAG
NSSQVSQNY
144
9
14
31
11211
|
|
GAG
NCGKEGIIIAK
427
10
14
22
11212
|
|
GAG
FNCGKEGIIIAK
426
11
14
22
11213
|
|
GAG
IAKNCRAPRKK
434
11
14
22
11214
|
|
GAG
QNAQGQMVII
157
9
14
22
11215
|
|
GAG
RGNFRNQRK
412
9
14
22
11216
|
|
GAG
CGKEGIIIAK
428
9
14
22
11217
|
|
GAG
EGIIIAKNCR
431
9
14
22
11218
|
|
GAG
FNTVATLYCV
81
11
14
22
11219
|
|
GAG
TVATLYCVIIQ
83
11
14
22
11220
|
|
GAG
IVQNAQGQMV
155
11
14
22
11221
|
|
GAG
SSQVSQNY
145
8
15
31
11222
|
|
GAG
RSLYNTVATL
78
11
15
24
11223
|
|
GAG
FNTVATLY
81
8
15
23
11224
|
|
GAG
TLYCVIIQR
86
8
15
23
11225
|
|
GAG
AAEWDRVII
230
8
15
23
11226
|
|
GAG
WDRVIIPVII
233
8
15
23
11227
|
|
GAG
RGNFRNQR
412
8
15
23
11228
|
|
GAG
LFNTVATLY
80
9
15
23
11229
|
|
GAG
ATLYCVIIQR
85
9
15
23
0.7100
11230
|
|
GAG
EAAEWDRVH
229
9
15
23
11231
|
|
GAG
TAPPEESFR
496
9
15
23
11232
|
|
GAG
SGGKLDAWEK
9
10
15
23
11233
|
|
GAG
SLFNTVATLY
79
10
15
23
11234
|
|
GAG
VATLYCVIIQR
84
10
15
23
11235
|
|
GAG
KIEEEQNKSK
105
10
15
23
11236
|
|
GAG
RAEQATQDVK
329
10
15
23
11237
|
|
GAG
PTAPPEESFR
495
10
15
23
11238
|
|
GAG
LSGGKLDAWE
8
11
15
23
11239
|
|
GAG
PGLLETSEGCR
50
11
15
23
11240
|
|
GAG
KIEEEQNKSKK
105
11
15
23
11241
|
|
GAG
MMQRGNFRN
409
11
15
23
11242
|
|
GAG
IAKNCRAPRK
434
10
16
25
11243
|
|
GAG
LDAWEKIR
13
8
16
25
11244
|
|
GAG
NAQGQMVH
158
8
16
25
11245
|
|
GAG
PVSILDIK
303
8
16
25
11246
|
|
GAG
GNFRNQRK
413
8
16
25
11247
|
|
GAG
KLDAWEKIR
12
9
16
25
11248
|
|
GAG
GGKKKYRLK
24
9
16
25
11249
|
|
GAG
LDAWEKIRLR
13
10
16
25
11250
|
|
GAG
PGGKKKYRLK
23
10
16
25
11251
|
|
GAG
GGKKKYRLKH
24
10
16
25
11252
|
|
GAG
GLLETSEGCR
51
10
16
25
11253
|
|
GAG
YSPVSILDIK
301
10
16
25
11254
|
|
GAG
GGKLDAWEKI
10
11
16
25
11255
|
|
GAG
KLDAWEKIRL
12
11
16
25
11256
|
|
GAG
PGGKKKYRLK
23
11
16
25
11257
|
|
GAG
VSILDIKQGPK
304
11
16
25
11258
|
|
GAG
HIAKNCRAPRK
433
11
16
25
11259
|
|
GAG
PIPPGQMR
243
8
17
27
11260
|
|
GAG
GGKLDAWEK
10
9
17
27
11261
|
|
GAG
DAWEKIRLR
14
9
17
27
11262
|
|
GAG
LLETSEGCR
52
9
17
27
11263
|
|
GAG
RLKHLVWASR
31
10
17
27
11264
|
|
GAG
LDKIEEEQNK
103
10
17
27
11265
|
|
GAG
AGPIPPGQMR
241
10
17
27
11266
|
|
GAG
ALDKIEEEQNK
102
11
17
27
11267
|
|
GAG
LSPRTLNAWV
168
11
17
27
11268
|
|
GAG
IIAGPIPPGQMR
240
11
17
27
11269
|
|
GAG
PIPPGQMREPR
243
11
17
27
11270
|
|
GAG
IAKNCRAPR
434
9
18
29
0.0003
11271
|
|
GAG
LDKWEKIR
13
8
18
28
11272
|
|
GAG
PVGDIYKR
281
8
18
28
11273
|
|
GAG
PDCKTILR
352
8
18
28
11274
|
|
GAG
LDKWEKIRLR
13
10
18
28
11275
|
|
GAG
SILDIKQGPK
305
10
18
28
11276
|
|
GAG
ANPDCKTILR
350
10
18
28
11277
|
|
GAG
IIIAKNCRAPR
433
10
18
28
11278
|
|
GAG
IIAGPIAPGQM
240
11
18
28
11279
|
|
GAG
NNPPIPVGEIY
273
11
18
28
11280
|
|
GAG
NANPDCKTILR
349
11
18
28
11281
|
|
GAG
LARNCRAPRK
434
11
19
30
11282
|
|
GAG
PIAPGQMR
243
8
19
30
11283
|
|
GAG
LDIKQGPK
307
8
19
30
11284
|
|
GAG
ILDIKQGPK
306
9
19
30
11285
|
|
GAG
AGPIAPGQMR
241
10
19
30
11286
|
|
GAG
IAPGQMREPR
244
10
19
30
11287
|
|
GAG
RLRPGGKKKY
20
11
19
30
11288
|
|
GAG
PIAPGQMREPR
243
11
19
30
11289
|
|
GAG
DIKQGPKEPFR
308
11
19
30
11290
|
|
GAG
LARNCRAPR
434
9
20
32
11291
|
|
GAG
LARNCRAPRK
434
10
20
32
11292
|
|
GAG
PGGKKKYR
23
8
20
31
11293
|
|
GAG
IMMQRGNFR
408
9
20
31
11294
|
|
GAG
KNCRAPRKK
436
9
20
31
11295
|
|
GAG
IVWASRELER
35
10
20
31
0.0066
11296
|
|
GAG
IILARNCRAPR
433
10
20
31
11297
|
|
GAG
HIVWASRELER
34
11
20
31
11298
|
|
GAG
IILARNCRAPR
433
11
20
31
11299
|
|
GAG
EGIILARNCR
431
9
21
33
11300
|
|
GAG
KIWPSHKGR
472
9
22
35
0.0005
11301
|
|
GAG
GGPSHKAR
378
8
22
34
11302
|
|
GAG
KNCRAPRK
436
8
22
34
11303
|
|
GAG
VGGPSHKAR
377
9
22
34
11304
|
|
GAG
SLYNTVATLY
79
10
22
34
11305
|
|
GAG
GVGGPSIIKAR
376
10
22
34
11306
|
|
GAG
QGVGGPSHKA
375
11
22
34
11307
|
|
GAG
LGKIWPSHKG
470
11
22
34
11308
|
|
GAG
NFLGKIWPSHK
468
11
23
37
11309
|
|
GAG
YNTVATLY
81
8
23
36
11310
|
|
GAG
KIEEEQNK
105
8
23
36
11311
|
|
GAG
QGVGGPSH
375
8
23
36
11312
|
|
GAG
GVGGPSIIK
376
8
23
36
11313
|
|
GAG
MMQRGNFR
409
8
23
36
11314
|
|
GAG
QGVGGPSIIK
375
9
23
36
11315
|
|
GAG
LGKIWPSIIK
470
9
23
36
11316
|
|
GAG
ACQGVGGPSH
373
10
23
36
11317
|
|
GAG
FLGKIWPSIIK
469
10
23
36
0.0013
11318
|
|
GAG
YNTVATLYCV
81
11
23
36
11319
|
|
GAG
TACQGVGGPS
372
11
23
36
11320
|
|
GAG
ACQGVGGPSII
373
11
23
36
11321
|
|
GAG
NCGKEGIILAR
427
10
24
38
11322
|
|
GAG
FNCGKEGIILA
426
11
24
38
11323
|
|
GAG
CGKEGIILAR
428
9
24
38
11324
|
|
GAG
YSPVSILDIR
301
10
24
38
11325
|
|
GAG
NFLGKIWPSH
468
10
25
40
11326
|
|
GAG
PVSILDIR
303
8
25
39
11327
|
|
GAG
LGKIWPSII
470
8
25
39
11328
|
|
GAG
KDTKEALDK
97
9
25
39
11329
|
|
GAG
FLGKIWPSII
469
9
25
39
11330
|
|
GAG
VSILDIRQGPK
304
11
25
39
11331
|
|
GAG
ANFLGKIWPSII
467
11
25
39
11332
|
|
GAG
LVWASRELER
35
10
26
41
11333
|
|
GAG
IILYWASRELE
34
11
26
41
11334
|
|
GAG
MVIIQAISPR
163
9
27
42
0.0670
11335
|
|
GAG
VDRFFKTLR
321
9
27
42
11336
|
|
GAG
QMVHQAISPR
162
10
27
42
0.0010
11337
|
|
GAG
YVDRFFKTLR
320
10
27
42
11338
|
|
GAG
RAEQATQEVK
329
10
27
42
11339
|
|
GAG
ANPDCKTILK
350
10
27
42
0.0002
11340
|
|
GAG
NANPDCKTILK
349
11
27
42
11341
|
|
GAG
KGRPGNFLQS
478
11
28
44
11342
|
|
GAG
PDCKTILK
352
8
28
44
11343
|
|
GAG
VDRFYKTLR
321
9
28
44
11344
|
|
GAG
PFRDYVDRFY
316
10
28
44
11345
|
|
GAG
YVDRFYKTLR
320
10
28
44
0.0006
11346
|
|
GAG
PFRDYVDRFY
316
11
28
44
11347
|
|
GAG
GARASVLSGG
2
11
29
46
11348
|
|
GAG
ASVLSGGK
5
8
29
45
11349
|
|
GAG
NLQGQMVH
158
8
29
45
11350
|
|
GAG
WVKVIEEK
176
8
29
45
11351
|
|
GAG
WDRLIIPVH
233
8
29
45
11352
|
|
GAG
RDYVDRFY
318
8
29
45
11353
|
|
GAG
RASVLSGGK
4
9
29
45
11354
|
|
GAG
QNLQGQMVH
157
9
29
45
11355
|
|
GAG
RDYVDRFYK
318
9
29
45
0.0400
11356
|
|
GAG
NAWVKVIEEK
174
10
29
45
11357
|
|
GAG
IVQNLQGQMV
155
11
29
45
11358
|
|
GAG
LNAWVKVIEE
173
11
29
45
11359
|
|
GAG
AAEWDRLIIPV
230
11
29
45
11360
|
|
GAG
PGNFLQSR
483
8
30
48
11361
|
|
GAG
NAWVKVVEEK
174
10
30
47
0.0002
11362
|
|
GAG
KIRLRPGGKKK
18
11
30
47
11363
|
|
GAG
LNAWVKVVEE
173
11
30
47
11364
|
|
GAG
WVKVVEEK
176
8
31
48
0.0001
11365
|
|
GAG
RDYVDRFFK
318
9
33
52
11366
|
|
GAG
RNCRAPRKK
436
9
33
52
11367
|
|
GAG
PFRDYVDRFF
316
11
33
52
11368
|
|
GAG
RNCRAPRK
436
8
34
53
11369
|
|
GAG
RLRPGGKKK
20
9
34
53
11370
|
|
GAG
RLRPGGKKKY
20
10
34
53
11371
|
|
GAG
PIPVGEIYKR
279
10
34
53
0.0001
11372
|
|
GAG
PIPVGEIY
279
8
35
55
11373
|
|
GAG
PIPYGEIYK
279
9
35
55
0.0012
11374
|
|
GAG
DTKEALDK
98
8
36
56
0.0001
11375
|
|
GAG
QGVGGPGH
375
8
36
56
11376
|
|
GAG
QGVGGPGIIK
375
9
36
56
0.0001
11377
|
|
GAG
ACQGVGGPGII
373
10
36
56
11378
|
|
GAG
ISPRTLNAWV
168
11
36
56
11379
|
|
GAG
TACQGVGGPG
372
11
36
56
0.0001
11380
|
|
GAG
ACQGVGGPGII
373
11
36
56
11381
|
|
GAG
QGVGGPGIIKA
375
11
36
56
11382
|
|
GAG
GVGGPGIIK
376
8
37
58
0.0018
11383
|
|
GAG
GGPGIIKAR
378
8
37
58
11384
|
|
GAG
VGGPGIIKAR
377
9
37
58
11385
|
|
GAG
GVGGPGHKAR
376
10
37
58
0.0001
11386
|
|
GAG
AAEWDRLII
230
8
39
61
11387
|
|
GAG
EAAEWDRLH
229
9
39
61
11388
|
|
GAG
PVGEIYKR
281
8
40
63
0.0001
11389
|
|
GAG
TVATLYCVH
83
9
40
63
11390
|
|
GAG
NTVATLYCVII
82
10
40
63
11391
|
|
GAG
SILDIRQGPK
305
10
40
63
0.7100
11392
|
|
GAG
DIRQGPKEPFR
308
11
41
64
11393
|
|
GAG
VATLYCVH
84
8
42
66
11394
|
|
GAG
LDIRQGPK
307
8
42
66
11395
|
|
GAG
ILDIRQGPK
306
9
42
66
0.0048
11396
|
|
GAG
NTMLNTVGGII
206
10
42
66
11397
|
|
GAG
LNTMLNTVGG
205
11
42
66
11398
|
|
GAG
TMLNTVGGH
207
9
43
67
11399
|
|
GAG
KGCWKCGK
444
8
44
69
11400
|
|
GAG
KIRLRPGGK
18
9
44
69
11401
|
|
GAG
KIRLRPGGKK
18
10
44
69
0.0010
11402
|
|
GAG
KGCWKCGKEG
444
11
44
69
11403
|
|
GAG
PGQMREPR
246
8
45
70
11404
|
|
GAG
CGKEGHQMK
449
9
45
70
11405
|
|
GAG
KCGKEGHQMK
448
10
45
70
11406
|
|
GAG
MLNTVGGH
208
8
47
73
11407
|
|
GAG
WASRELER
37
8
48
75
11408
|
|
GAG
GCWKCGKEGH
445
10
48
75
11409
|
|
GAG
RLRPGGKK
20
8
49
77
11410
|
|
GAG
QMKDCTER
455
8
49
77
11411
|
|
GAG
EGHQMKDCTE
452
11
49
77
11412
|
|
GAG
RAPRKKGCWK
439
10
51
80
11413
|
|
GAG
CTERQANFLG
459
11
52
83
11414
|
|
GAG
NCRAPRKK
437
8
53
84
11415
|
|
GAG
TINEEAAEWD
225
11
53
83
11416
|
|
GAG
INEEAAEWDR
226
10
55
86
11417
|
|
GAG
FNCGKEGII
426
8
57
90
11418
|
|
GAG
WIILGLNK
289
8
57
89
11419
|
|
GAG
CFNCGKEGH
425
9
57
89
11420
|
|
GAG
IILGLNKIVR
290
10
57
89
0.0006
11421
|
|
GAG
KCFNCGKEGII
424
10
57
89
11422
|
|
GAG
WIILGLNKIVR
289
11
57
89
11423
|
|
GAG
ILGLNKIVRMY
291
11
57
89
11424
|
|
GAG
ILGLNKIVR
291
9
58
91
0.0001
11425
|
|
GAG
LGLNKIVRMY
292
10
58
91
0.0002
11426
|
|
GAG
LLVQNANPDC
345
11
58
91
11427
|
|
GAG
LGLNKIVR
292
8
59
92
11428
|
|
GAG
LVQNANPDCK
346
10
59
92
0.0110
11429
|
|
GAG
LNKIVRMY
294
8
60
94
11430
|
|
GAG
GLNKIVRMY
293
9
60
94
0.0002
11431
|
|
GAG
QAAMQMLK
216
8
61
95
11432
|
|
GAG
QNANPDCK
348
8
61
95
11433
|
|
GAG
GGIIQAAMQM
213
11
61
95
11434
|
|
GAG
RTLNAWVK
171
8
63
98
0.0560
11435
|
|
GAG
QGPKEPFR
311
8
63
98
11436
|
|
GAG
PFRDYVDR
316
8
63
98
11437
|
|
GAG
QGPKEPFRDY
311
10
63
98
0.0002
11438
|
|
NEF
AADGVGAVSR
42
10
09
15
11439
|
|
NEF
ANEGENNSLLII
249
11
09
15
11440
|
|
NEF
VGWPAIRER
11
9
10
17
11441
|
|
NEF
FDSRLAFII
310
8
10
16
11442
|
|
NEF
FDSRLAFIIII
310
9
10
16
11443
|
|
NEF
DSRLAFIIII
311
8
10
16
11444
|
|
NEF
AVSQDLDK
48
8
10
16
11445
|
|
NEF
PLRPMTFK
102
8
10
16
11446
|
|
NEF
GAVSQDLDK
47
9
10
16
11447
|
|
NEF
GLEGLIYSK
125
9
10
16
11448
|
|
NEF
MARELHPEY
321
9
10
16
11449
|
|
NEF
VGAVSQDLDK
46
10
10
16
11450
|
|
NEF
QVPLRPMTFK
100
10
10
16
11451
|
|
NEF
GAFDLSFFLK
110
10
10
16
11452
|
|
NEF
GGLEGLIYSK
124
10
10
16
11453
|
|
NEF
CFKLVPVDPR
226
10
10
16
11454
|
|
NEF
HMARELHPEY
320
10
10
16
11455
|
|
NEF
MARELHPEYY
321
10
10
16
11456
|
|
NEF
GVGAVSQDLD
45
11
10
16
11457
|
|
NEF
KGAFDLSFFLK
109
11
10
16
11458
|
|
NEF
KGGLEGLIYSK
122
11
10
16
11459
|
|
NEF
WCFKLVPVDP
225
11
10
16
11460
|
|
NEF
NNSLLHPICQII
254
11
10
16
11461
|
|
NEF
HMARELHPEY
320
11
10
16
11462
|
|
NEF
MARELIIPEYY
321
11
10
16
11463
|
|
NEF
ANEGENNCLL
249
11
11
18
11464
|
|
NEF
AVSRDLEK
48
8
11
17
11465
|
|
NEF
VSRDLEKII
49
8
11
17
11466
|
|
NEF
KLVPVDPR
228
8
11
17
11467
|
|
NEF
GAVSRDLEK
47
9
11
17
0.0009
11468
|
|
NEF
AVSRDLEKII
48
9
11
17
11469
|
|
NEF
VGAVSRDLEK
46
10
11
17
11470
|
|
NEF
GAVSRDLEKH
47
10
11
17
11471
|
|
NEF
QNYTPGPGVR
205
10
11
17
11472
|
|
NEF
NSLLIIPICQII
255
10
11
17
11473
|
|
NEF
GVGAVSRDLE
45
11
11
17
11474
|
|
NEF
VGAVSRDLEK
46
11
11
17
11475
|
|
NEF
EGENNCLLII
251
9
12
19
11476
|
|
NEF
YTPGPGVR
207
8
12
19
11477
|
|
NEF
DILDLWVYII
185
9
12
19
11478
|
|
NEF
QDILDLWVYII
184
10
12
19
11479
|
|
NEF
EGENNSLLII
251
9
13
21
11480
|
|
NEF
VDLSIIFLKEK
112
10
13
20
11481
|
|
NEF
AVDLSIIFLKEK
111
11
13
20
11482
|
|
NEF
VDLSIIFLK
112
8
14
22
11483
|
|
NEF
DGLIYSKK
172
8
14
22
11484
|
|
NEF
ELHPEFYK
324
8
14
22
11485
|
|
NEF
AVDLSIIFLK
111
9
14
22
1.1000
11486
|
|
NEF
LDGLIYSKK
171
9
14
22
11487
|
|
NEF
DGLIYSKKR
172
9
14
22
11488
|
|
NEF
SLLHPICQH
256
9
14
22
11489
|
|
NEF
GLDGLIYSKK
125
10
14
22
11490
|
|
NEF
LDGLIYSKKR
171
10
14
22
11491
|
|
NEF
GGLDGLIYSKK
124
11
14
22
11492
|
|
NEF
GLDGLIYSKKR
125
11
14
22
11493
|
|
NEF
NNCLLIIPMSQ
254
11
14
22
11494
|
|
NEF
CLLHPMSQH
256
9
15
23
11495
|
|
NEF
NCLLHPMSQII
255
10
15
23
11496
|
|
NEF
QNYTPGPGIRY
205
11
15
23
11497
|
|
NEF
LDGLIYSK
171
8
16
25
11498
|
|
NEF
GLDGLIYSK
125
9
16
25
11499
|
|
NEF
GGLDGLIYSK
124
10
16
25
11500
|
|
NEF
KGGLDGLIYSK
122
11
16
25
11501
|
|
NEF
RFPLTFGWCF
216
11
17
27
11502
|
|
NEF
FFPDWQNY
199
8
17
27
11503
|
|
NEF
LLHPMSQII
257
8
17
27
11504
|
|
NEF
GFFPDWQNY
198
9
17
27
11505
|
|
NEF
YTPGPGIRY
207
9
17
27
11506
|
|
NEF
FDLSFFLKEK
112
10
17
27
11507
|
|
NEF
QGFFPDWQNY
196
10
17
27
11508
|
|
NEF
AFDLSFFLKEK
111
11
17
27
11509
|
|
NEF
FDLSFFLK
112
8
18
28
11510
|
|
NEF
LLIIPICQII
257
8
18
28
11511
|
|
NEF
AFDLSFFLK
111
9
18
28
11512
|
|
NEF
QNYTPGPGIR
205
10
18
28
11513
|
|
NEF
GGLEGLIY
124
8
19
30
11514
|
|
NEF
KGGLEGLIY
122
9
19
30
11515
|
|
NEF
DILDLWVY
185
8
20
31
11516
|
|
NEF
YTPGPGIR
207
8
20
31
11517
|
|
NEF
QDILDLWVY
184
9
20
31
11518
|
|
NEF
QNYTPGPGTR
205
10
20
31
11519
|
|
NEF
GGLDGLIY
124
8
21
33
11520
|
|
NEF
WVYIITQGY
191
8
21
33
11521
|
|
NEF
YTPGPGTR
207
8
21
33
11522
|
|
NEF
KGGLDGLIY
122
9
21
33
11523
|
|
NEF
DLWVYIITQGY
188
10
21
33
11524
|
|
NEF
LDLWVYIITQG
187
11
21
33
11525
|
|
NEF
LSFFLKEK
114
8
22
34
11526
|
|
NEF
ELIIPEYYK
324
8
22
34
11527
|
|
NEF
DLSFFLKEK
113
9
22
34
11528
|
|
NEF
EILDLWVYH
185
9
22
34
11529
|
|
NEF
GLIYSKKR
173
8
23
36
11530
|
|
NEF
LSIIFLKEK
114
8
27
42
11531
|
|
NEF
DLSIIFLKEK
113
9
27
42
11532
|
|
NEF
EILDLWVY
185
8
33
52
11533
|
|
NEF
ILDLWVYII
186
8
34
53
11534
|
|
NEF
YFPDWQNY
199
8
36
56
11535
|
|
NEF
QGYFPDWQNY
196
10
36
56
0.0017
11536
|
|
NEF
LTFGWCFK
221
8
39
61
11537
|
|
NEF
PLTFGWCFK
219
9
39
61
11538
|
|
NEF
QVPLRPMTY
100
9
46
72
11539
|
|
NEF
QVPLRPMTYK
100
10
46
72
0.6300
11540
|
|
NEF
PVRPQVPLR
95
9
48
75
11541
|
|
NEF
GFPVRPQVPLR
93
11
48
75
11542
|
|
NEF
PLRPMTYK
102
8
49
77
0.0003
11543
|
|
POL
STNSPTSR
32
8
01
33
11544
|
|
POL
RANSPSSR
35
8
01
33
11545
|
|
POL
NSTNSPTSR
31
9
01
33
11546
|
|
POL
PTSRELQVR
36
9
01
33
11547
|
|
POL
QTRANSPSSR
33
10
01
33
11548
|
|
POL
QTRANSPTTR
35
10
01
33
11549
|
|
POL
NSPTSRELQVR
34
11
01
33
11550
|
|
POL
RANSPTTR
37
8
01
50
11551
|
|
POL
PSSRELQVR
39
9
01
50
11552
|
|
POL
PSRANSPTSR
24
10
01
50
11553
|
|
POL
NSPSSRELQVR
37
11
01
50
11554
|
|
POL
NSPTTRELQV
39
11
01
50
11555
|
|
POL
NNSLSEAGAD
55
11
05
25
11556
|
|
POL
NLAFPQGEAR
5
10
10
16
11557
|
|
POL
ILIEICGII
149
8
10
16
11558
|
|
POL
LIEICGIIK
150
8
10
16
11559
|
|
POL
YAKMRTAII
546
8
10
16
11560
|
|
POL
RSAHTNDVK
550
9
10
16
11561
|
|
POL
ETWETWWTD
588
10
10
16
11562
|
|
POL
ETWETWWTE
588
10
10
16
11563
|
|
POL
VSLTDTTNQK
659
10
10
16
11564
|
|
POL
ENLAFPQGEAR
4
11
10
16
11565
|
|
POL
TGKYAKMRTA
543
11
10
16
11566
|
|
POL
VVSLTDTTNQ
658
11
10
16
11567
|
|
POL
QTKELQKQIIK
961
11
10
16
11568
|
|
POL
QTRANSPTRR
21
10
11
18
11569
|
|
POL
TNNETPGIR
324
9
11
17
11570
|
|
POL
TNNETPGIRY
324
10
11
17
11571
|
|
POL
LDGIDKAQEDII
754
11
11
17
11572
|
|
POL
IGGFIKVK
137
8
11
17
11573
|
|
POL
RIGPENPY
238
8
11
17
11574
|
|
POL
TAIITNDVK
551
8
11
17
11575
|
|
POL
QLTEVVQK
559
8
11
17
11576
|
|
POL
IDKAQEDH
757
8
11
17
11577
|
|
POL
VVPRRKVK
1012
8
11
17
11578
|
|
POL
KIIKDYGK
1019
8
11
17
11579
|
|
POL
GIGGFIKVK
136
9
11
17
11580
|
|
POL
SLTDTTNQK
660
9
11
17
11581
|
|
POL
GIDKAQEDII
756
9
11
17
11582
|
|
POL
SNFTSTTVK
871
9
11
17
11583
|
|
POL
KVVPRRKVK
1011
9
11
17
11584
|
|
POL
GGIGGFIKVK
135
10
11
17
11585
|
|
POL
ISRIGPENPY
236
10
11
17
11586
|
|
POL
STNNETPGIR
323
10
11
17
11587
|
|
POL
ESWTVNDIQK
439
10
11
17
11588
|
|
POL
ETTNQKTELH
663
10
11
17
11589
|
|
POL
DGIDKAQEDH
755
10
11
17
11590
|
|
POL
GSNFTSTTVK
870
10
11
17
11591
|
|
POL
GIQQEFGIPY
886
10
11
17
11592
|
|
POL
SDIQTKELQK
958
10
11
17
11593
|
|
POL
FNFPQITLWQR
85
11
11
17
11594
|
|
POL
IGGIGGFIKVK
134
11
11
17
11595
|
|
POL
KISRIGPENPY
235
11
11
17
11596
|
|
POL
PSTNNETPGIR
322
11
11
17
11597
|
|
POL
STNNETPGIRY
323
11
11
17
11598
|
|
POL
VVSLTETTNQ
658
11
11
17
11599
|
|
POL
NGSNFTSTTV
869
11
11
17
11600
|
|
POL
AGIQQEFGIPY
885
11
11
17
11601
|
|
POL
IDIIASDIQTK
953
11
11
17
11602
|
|
POL
VDIIATDIQTK
953
11
11
17
11603
|
|
POL
ASDIQTKELQK
957
11
11
17
11604
|
|
POL
NSEIKVVPRRK
1007
11
11
17
11605
|
|
POL
QTRANSPTSR
21
10
12
19
11606
|
|
POL
IIKIQNFR
969
8
12
19
11607
|
|
POL
QIYPGIKVK
458
9
12
19
11608
|
|
POL
QDQWTYQIY
526
9
12
19
11609
|
|
POL
IIKIQNFRVY
969
10
12
19
11610
|
|
POL
ASQIYPGIKVK
456
11
12
19
11611
|
|
POL
IIKIQNFRVYY
969
11
12
19
11612
|
|
POL
AFPQGEAR
7
8
12
19
11613
|
|
POL
TNQKTELII
665
8
12
19
11614
|
|
POL
KTELQAIY
668
8
12
19
11615
|
|
POL
LAFPQGEAR
6
9
12
19
11616
|
|
POL
EINLPGKWK
122
9
12
19
11617
|
|
POL
TTNQKTELII
664
9
12
19
11618
|
|
POL
QIIKIQNFR
968
9
12
19
11619
|
|
POL
VIQDNSEIK
1003
9
12
19
11620
|
|
POL
NSEIKVVPR
1007
9
12
19
11621
|
|
POL
VLEEINLPGK
119
10
12
19
11622
|
|
POL
VVIQDNSEIK
1002
10
12
19
11623
|
|
POL
DNSEIKVVPR
1006
10
12
19
11624
|
|
POL
NSEIKVVPRR
1007
10
12
19
11625
|
|
POL
TVLEEINLPGK
118
11
12
19
11626
|
|
POL
EINLPGKWKPK
122
11
12
19
11627
|
|
POL
QGQDQWTYQI
524
11
12
19
11628
|
|
POL
RMRGAIITNDV
548
11
12
19
11629
|
|
POL
TNQKTELQAIY
665
11
12
19
11630
|
|
POL
QIIKIQNFRVY
968
11
12
19
11631
|
|
POL
AVVIQDNSEIK
1000
11
12
19
11632
|
|
POL
QDNSEIKVVPR
1005
11
12
19
11633
|
|
POL
DNSEIKVVPRR
1006
11
12
19
11634
|
|
POL
ELQKQIIK
964
8
13
21
11635
|
|
POL
KTGKYARMR
542
9
13
21
11636
|
|
POL
NLKTGKYARM
540
11
13
21
11637
|
|
POL
EDINLPGK
121
8
13
20
11638
|
|
POL
TGKYARMR
543
8
13
20
11639
|
|
POL
YARMRGAH
546
8
13
20
11640
|
|
POL
QVREQAEII
916
8
13
20
11641
|
|
POL
DINLPGKWK
122
9
13
20
11642
|
|
POL
VLEDINLPGK
119
10
13
20
11643
|
|
POL
EDINLPGKWK
121
10
13
20
11644
|
|
POL
RAKIEELREII
388
10
13
20
11645
|
|
POL
TVQPIVLPEK
429
10
13
20
5.6000
11646
|
|
POL
AGRWPVKTIII
857
10
13
20
11647
|
|
POL
IGQVREQAEH
914
10
13
20
11648
|
|
POL
QVREQAEHLK
916
10
13
20
11649
|
|
POL
TLWQRPLVTV
91
11
13
20
11650
|
|
POL
LVTIKIGGQLK
97
11
13
20
11651
|
|
POL
TVLEDINLPGK
118
11
13
20
11652
|
|
POL
DINLPGKWKP
122
11
13
20
11653
|
|
POL
KIEELREIILLK
390
11
13
20
11654
|
|
POL
WTVQPIVLPEK
428
11
13
20
0.0510
11655
|
|
POL
TGKYARMRGA
543
11
13
20
11656
|
|
POL
LAGRWPVKTI
856
11
13
20
11657
|
|
POL
IIGQVREQAEH
913
11
13
20
11658
|
|
POL
EIKVVPRRKAK
1009
11
13
20
11659
|
|
POL
EFSSEQTR
16
8
14
22
11660
|
|
POL
QIYPGIKVR
458
9
14
22
11661
|
|
POL
ASQIYPGIKVR
456
11
14
22
11662
|
|
POL
IATESIVIWGK
567
11
14
22
11663
|
|
POL
ILIEICGK
149
8
14
22
11664
|
|
POL
LIEICGKK
150
8
14
22
11665
|
|
POL
QNPDIVIY
363
8
14
22
11666
|
|
POL
NFTSTTVK
872
8
14
22
11667
|
|
POL
IASDIQTK
956
8
14
22
11668
|
|
POL
DSRDPLWK
981
8
14
22
11669
|
|
POL
QILIEICGK
148
9
14
22
11670
|
|
POL
ILIEICGKK
149
9
14
22
11671
|
|
POL
IIASDIQTK
955
9
14
22
11672
|
|
POL
RDSRDPLWK
980
9
14
22
11673
|
|
POL
QILIEICGKK
148
10
14
22
11674
|
|
POL
QNPDIVIYQY
363
10
14
22
11675
|
|
POL
RTKIEELRQH
388
10
14
22
11676
|
|
POL
PGIKVRQLCK
461
10
14
22
11677
|
|
POL
DIIASDIQTK
954
10
14
22
11678
|
|
POL
RDPLWKGPAK
983
10
14
22
11679
|
|
POL
FSFPQITLWQR
85
11
14
22
11680
|
|
POL
YDQILIEICGK
146
11
14
22
11681
|
|
POL
KTPKFKLPIQK
577
11
14
22
11682
|
|
POL
GIDKAQEEIIER
756
11
14
22
11683
|
|
POL
QTRANSPTR
21
9
15
24
11684
|
|
POL
LVEICTEMEK
221
10
15
24
0.0120
11685
|
|
POL
ELRQIILLR
393
8
15
23
11686
|
|
POL
QGQDQWTY
524
8
15
23
11687
|
|
POL
KTELQAIII
668
8
15
23
11688
|
|
POL
EIKVVPRRK
1009
9
15
23
11689
|
|
POL
LGIIQAQPDR
695
10
15
23
11690
|
|
POL
VDKLVSAGIR
740
10
15
23
11691
|
|
POL
IDKAQEEIIER
757
10
15
23
11692
|
|
POL
ALVEICTEMEK
220
11
15
23
11693
|
|
POL
KIEELRQIILLR
390
11
15
23
11694
|
|
POL
TNQKTELQAIH
665
11
15
23
11695
|
|
POL
ALGIIQAQPDR
694
11
15
23
11696
|
|
POL
LVNQIIEQLIK
709
11
15
23
11697
|
|
POL
QVDKLVSAGIR
739
11
15
23
11698
|
|
POL
VDKLVSAGIRK
740
11
15
23
11699
|
|
POL
IDKAQEEHERY
757
11
15
23
11700
|
|
POL
KAQIEEIIER
759
8
16
25
11701
|
|
POL
KAQEEIIERY
759
9
16
25
11702
|
|
POL
NLAFQQGEAR
5
10
16
25
11703
|
|
POL
KAQEEHERYH
759
10
16
25
11704
|
|
POL
AFQQGEAR
7
8
16
25
11705
|
|
POL
RANSPTRR
26
8
16
25
11706
|
|
POL
SAHTNDVK
551
8
16
25
11707
|
|
POL
IIQAQPDR
697
8
16
25
11708
|
|
POL
KLVSAGIR
742
8
16
25
11709
|
|
POL
LYSAGIRK
743
8
16
25
0.0054
11710
|
|
POL
EIKVVPRR
1009
8
16
25
11711
|
|
POL
LAFQQGEAR
6
9
16
25
11712
|
|
POL
GIIQAQPDR
696
9
16
25
11713
|
|
POL
KLVSAGIRK
742
9
16
25
0.0770
11714
|
|
POL
ENLAFQQGEA
4
11
16
25
11715
|
|
POL
RANSPTSR
26
8
17
27
11716
|
|
POL
KIEELRQII
390
8
17
27
11717
|
|
POL
ELREHLLK
393
8
17
27
11718
|
|
POL
WGKTPKFK
575
8
17
27
11719
|
|
POL
TIKIGGQLK
99
9
17
27
0.0330
11720
|
|
POL
VTIKIGGQLK
98
10
17
27
0.2100
11721
|
|
POL
TVQPIQLPEK
429
10
17
27
11722
|
|
POL
VIWGKTPKFK
573
10
17
27
11723
|
|
POL
TLWQRPLVTI
91
11
17
27
11724
|
|
POL
WTVQPIQLPEK
428
11
17
27
11725
|
|
POL
IVIWGKTPKFK
572
11
17
27
11726
|
|
P01
YFSVPLDKDFR
304
11
18
29
11727
|
|
POL
NLKTGKYAKM
540
11
18
29
11728
|
|
POL
PDIVIYQY
365
8
18
28
11729
|
|
POL
SVPLDKDFR
306
9
18
28
11730
|
|
POL
FSVPLDKDFR
305
10
18
28
11731
|
|
POL
SVPLDKDFRK
306
10
18
28
11732
|
|
POL
AGIKVKQLCK
461
10
18
28
11733
|
|
POL
VNQIIEQLIK
710
10
18
28
11734
|
|
POL
FSVPLDKDFRK
305
11
18
28
11735
|
|
POL
SVPLDKDFRK
306
11
18
28
11736
|
|
POL
YAGIKVKQLCK
460
11
18
28
11737
|
|
POL
LVSQIIEQLIK
709
11
18
28
11738
|
|
POL
VNQIIEQLIKK
710
11
18
28
11739
|
|
POL
PLDKDFRK
308
8
19
30
11740
|
|
POL
PLDKDFRKY
308
9
19
30
11741
|
|
POL
KTGKYAKMR
542
9
19
30
11742
|
|
POL
LDKDFRKY
309
8
19
30
11743
|
|
POL
KIEELREH
390
8
19
30
11744
|
|
POL
TGKYAKMR
543
8
19
30
11745
|
|
POL
GAHTNDVK
551
8
19
30
11746
|
|
POL
LTDTTNQK
661
8
19
30
11747
|
|
POL
PLWKGPAK
985
8
19
30
11748
|
|
POL
GIKVRQLCK
462
9
19
30
11749
|
|
POL
RGAHTNDVK
550
9
19
30
11750
|
|
POL
KVRQLCKLLR
464
10
19
30
11751
|
|
POL
ATESIVIWGK
568
10
19
30
11752
|
|
POL
VSQIIEQLIK
710
10
19
30
0.0370
11753
|
|
POL
MAGDDCVASR
1028
10
19
30
11754
|
|
POL
VSQIIEQLIKK
710
11
19
30
11755
|
|
POL
QMAGDDCVAS
1027
11
19
30
11756
|
|
POL
QIYAGIKVK
458
9
20
32
11757
|
|
POL
KVYLAWVPAH
722
10
20
32
0.0036
11758
|
|
POL
KAACWWAGIK
879
10
20
32
0.0740
11759
|
|
POL
ASQIYAGIKVK
456
11
20
32
11760
|
|
POL
KVYLAWVPAH
722
11
20
32
2.3000
11761
|
|
POL
KFKLPIQK
580
8
20
31
11762
|
|
POL
GDDCVASR
1030
8
20
31
11763
|
|
POL
AGDDCVASR
1029
9
20
31
11764
|
|
POL
VSLTETTNQK
659
10
20
31
11765
|
|
POL
LLKLAGRWPV
853
11
20
31
11766
|
|
POL
YFSVPLDK
304
8
21
33
11767
|
|
POL
ACWWAGIK
881
8
21
33
11768
|
|
POL
SLTETTNQK
660
9
21
33
11769
|
|
POL
AACWWAGIK
880
9
21
33
0.0470
11770
|
|
POL
DAYFSVPLDK
302
10
21
33
11771
|
|
POL
DLEIGQIIRTK
381
10
21
33
11772
|
|
POL
QLCKLLRGTK
467
10
21
33
11773
|
|
POL
IFAIKKKDSTK
249
11
21
33
11774
|
|
POL
GDAYFSVPLD
301
11
21
33
11775
|
|
POL
SDLEIGQHRTK
380
11
21
33
11776
|
|
POL
SDFNLPPIVAK
776
11
21
33
11777
|
|
POL
AGIKQEFGIPY
885
11
21
33
11778
|
|
POL
EIGQIIRTK
383
8
22
34
11779
|
|
POL
RTKIEELR
388
8
22
34
11780
|
|
POL
YLAWVPAII
724
8
22
34
11781
|
|
POL
LAWVPAIIK
725
8
22
34
11782
|
|
POL
YLAWVPAIIK
724
9
22
34
0.0570
11783
|
|
POL
NFPQITLWQR
86
10
22
34
11784
|
|
POL
MTKILEPFRK
353
10
22
34
0.0380
11785
|
|
POL
AGRWPVKVIH
857
10
22
34
11786
|
|
POL
GIKQEFGIPY
886
10
22
34
0.0002
11787
|
|
POL
SMTKILEPFRK
352
11
22
34
11788
|
|
POL
KTPKPRLPIQK
577
11
22
34
11789
|
|
POL
LAGRWPVKVI
856
11
22
34
11790
|
|
POL
KVYLSWVPAH
722
10
23
37
11791
|
|
POL
KVYLSWVPAII
722
11
23
37
11792
|
|
POL
KILEPFRK
355
8
23
36
11793
|
|
POL
KVILVAVII
823
8
23
36
11794
|
|
POL
SFPQITLWQR
86
10
23
36
11795
|
|
POL
DFNLPPIVAK
777
10
23
36
11796
|
|
POL
EGKVILVAVII
821
10
23
36
11797
|
|
POL
LLKWGFTTPD
398
11
23
36
11798
|
|
POL
LLRWGPTTPD
398
11
23
36
11799
|
|
POL
IDIIATDIQTK
953
11
23
36
11800
|
|
POL
NTPIFAIK
246
8
24
38
11801
|
|
POL
GDDCVAGR
1030
8
24
38
11802
|
|
POL
YNTPIFAIK
245
9
24
38
11803
|
|
POL
NTPIFAIKK
246
9
24
38
11804
|
|
POL
LCKLLRGTK
468
9
24
38
0.0001
11805
|
|
POL
AGDDCVAGR
1029
9
24
38
11806
|
|
POL
YNTPIFAIKK
245
10
24
38
11807
|
|
POL
NTPIFAIKKK
246
10
24
38
11808
|
|
POL
MAGDDCVAGR
1028
10
24
38
11809
|
|
POL
YNTPIFAIKKK
245
11
24
38
11810
|
|
POL
QGQGQWTYQI
524
11
24
38
11811
|
|
POL
KLGKAGYVTD
643
11
24
38
11812
|
|
POL
TAYFLLKLAG
849
11
24
38
11813
|
|
POL
QMAGDDCVAG
1027
11
24
38
11814
|
|
POL
QGQWTYQIY
526
9
25
40
0.0001
11815
|
|
POL
PIFAIKKK
248
8
25
39
11816
|
|
POL
QGQGQWTY
524
8
25
39
11817
|
|
POL
FLLKLAGR
852
8
25
39
11818
|
|
POL
YFLLKLAGR
851
9
25
39
11819
|
|
POL
QLCKLLRGAK
467
10
25
39
11820
|
|
POL
LGKAGYVTDR
644
10
25
39
11821
|
|
POL
IDKAQEEIIEK
757
10
25
39
11822
|
|
POL
PSKDLIAEIQK
513
11
25
39
11823
|
|
POL
GIDKAQEEHEK
756
11
25
39
11824
|
|
POL
IDKAQEEHEKY
757
11
25
39
11825
|
|
POL
SDFNLPPVVAK
776
11
25
39
11826
|
|
POL
RAKIEELR
388
8
26
41
11827
|
|
POL
KFRLPIQK
580
8
26
41
11828
|
|
POL
NLPPIVAK
779
8
26
41
11829
|
|
POL
LCKLLRGAK
468
9
26
41
11830
|
|
POL
FNLPPIVAK
778
9
26
41
11831
|
|
POL
SNFTSAAVK
871
9
26
41
11832
|
|
POL
DFNLPPVVAK
777
10
26
41
11833
|
|
POL
GSNFTSAAVK
870
10
26
41
11834
|
|
POL
TGQETAYFLL
845
11
26
41
11835
|
|
POL
NGSNFTSAAV
869
11
26
41
11836
|
|
POL
KAQEEIIEK
759
8
27
43
11837
|
|
POL
ASQIYAGIK
456
9
27
43
0.3400
11838
|
|
POL
KAQEEIIEKY
759
9
27
43
11839
|
|
POL
KAQEEHEKYH
759
10
27
43
11840
|
|
POL
INLPGKWK
123
8
27
42
11841
|
|
POL
EICTEMEK
223
8
27
42
11842
|
|
POL
EIGQHRAK
383
8
27
42
11843
|
|
POL
LVSSGIRK
743
8
27
42
11844
|
|
POL
NLPPVVAK
779
8
27
42
11845
|
|
POL
ETAYFLLK
848
8
27
42
0.0430
11846
|
|
POL
KLVSSGIRK
742
9
27
42
11847
|
|
POL
FNLPPVVAK
778
9
27
42
11848
|
|
POL
INLPGKWKPK
123
10
27
42
11849
|
|
POL
DLEIGQIIRAK
381
10
27
42
11850
|
|
POL
WASQIYAGIK
455
10
27
42
11851
|
|
POL
KVKQLCKLLR
464
10
27
42
11852
|
|
POL
EICTEMEKEGK
223
11
27
42
11853
|
|
POL
SDLEIGQHRAK
380
11
27
42
11854
|
|
POL
VDKLVSSGIRK
740
11
27
42
11855
|
|
POL
ASQIYPGIK
456
9
28
44
11856
|
|
POL
KDLIAEIQK
515
9
28
44
11857
|
|
POL
NLKTGKYAK
540
9
28
44
11858
|
|
POL
DLIAEIQK
516
8
28
44
11859
|
|
POL
IVGAETFY
626
8
28
44
11860
|
|
POL
NFTSAAVK
872
8
28
44
11861
|
|
POL
CTEMEKEGK
225
9
28
44
0.0001
11862
|
|
POL
GIKVKQLCK
462
9
28
44
11863
|
|
POL
PIVGAETFY
625
9
28
44
11864
|
|
POL
QLIKKEKVY
716
9
28
44
11865
|
|
POL
ICTEMEKEGK
224
10
28
44
11866
|
|
POL
WASQIYPGIK
455
10
28
44
11867
|
|
POL
KNLKTGKYAK
539
10
28
44
11868
|
|
POL
NLKTGKYAR
540
9
29
46
0.0001
11869
|
|
POL
KLVSSGIR
742
8
29
45
11870
|
|
POL
KNLKIGKYAR
539
10
29
45
11871
|
|
POL
VIWGKTPKFR
573
10
29
45
11872
|
|
POL
VDKLVSSGIR
740
10
29
45
11873
|
|
POL
IVIWGKTPKFR
572
11
29
45
11874
|
|
POL
QVDKLVSSGIR
739
11
29
45
11875
|
|
POL
WGKTPKFR
575
8
30
47
11876
|
|
POL
LTETTNQK
661
8
30
47
11877
|
|
POL
ANRIETKLGK
638
9
30
47
0.0001
11878
|
|
POL
AANREIKLGK
637
10
30
47
0.0016
11879
|
|
POL
IIEQLIKKEK
713
10
30
47
0.0003
11880
|
|
POL
GAANRETKLG
636
11
30
47
11881
|
|
POL
QIIEQLIKKEK
712
11
30
47
11882
|
|
POL
ILKLAGRWPV
853
11
30
47
11883
|
|
POL
KIILVAVII
823
8
31
48
11884
|
|
POL
ETAYFILK
848
8
31
48
11885
|
|
POL
YFILKLAGR
851
9
31
48
11886
|
|
POL
EGKIILVAVH
821
10
31
48
11887
|
|
POL
PSINNETPGIR
322
11
31
48
11888
|
|
POL
TGQETAYFILK
845
11
31
48
11889
|
|
POL
TAYFILKLAGR
849
11
31
48
11890
|
|
POL
INNETPGIR
324
9
32
51
11891
|
|
POL
INNETPGIRY
324
10
32
51
11892
|
|
POL
FILKLAGR
852
8
32
50
11893
|
|
POL
SINNETPGIR
323
10
32
50
11894
|
|
POL
SINNETPGIRY
323
11
32
50
11895
|
|
POL
SSMTKILEPFR
351
11
32
50
11896
|
|
POL
QTKELQKQITK
961
11
32
50
0.0100
11897
|
|
POL
EMEKEGKISK
229
10
33
52
0.0001
11898
|
|
POL
DVKQLTEAVQ
556
11
33
52
0.0240
11899
|
|
POL
DIIATDIQTK
954
10
34
53
0.0130
11900
|
|
POL
ELQKQITK
964
8
35
56
11901
|
|
POL
LIKKEKVY
717
8
35
55
11902
|
|
POL
DSRDPIWK
981
8
35
55
11903
|
|
POL
ETKLGKAGY
641
9
35
55
11904
|
|
POL
IIATDIQTK
955
9
35
55
0.0980
11905
|
|
POL
QITKIQNFR
968
9
35
55
0.0045
11906
|
|
POL
RDSRDPIWK
980
9
35
55
11907
|
|
POL
TDIQTKELQK
958
10
35
55
0.0001
11908
|
|
POL
RDPIWKGPAK
983
10
35
55
11909
|
|
POL
ATDIQTKELQK
957
11
35
55
0.1800
11910
|
|
POL
QITKIQNFRVY
968
11
35
55
11911
|
|
POL
ITKIQNFR
969
8
36
57
11912
|
|
POL
ITKIQNFRVY
969
10
36
57
0.0012
11913
|
|
POL
ITKIQNFRVYY
969
11
36
57
11914
|
|
POL
IATDIQTK
956
8
36
56
11915
|
|
POL
PIWKGPAK
985
8
36
56
11916
|
|
POL
NLPGKWKPK
124
9
36
56
11917
|
|
POL
AIFQSSMTK
347
9
36
56
0.9600
11918
|
|
POL
PAIFQSSMTK
346
10
36
56
0.0830
11919
|
|
POL
VFAIKKKDSTK
249
11
36
56
11920
|
|
POL
NTPVPAIK
246
8
37
58
0.0003
11921
|
|
POL
PVFAIKKK
248
8
37
58
0.0001
11922
|
|
POL
QLTEAVQK
559
8
37
58
11923
|
|
POL
QIIEQLIK
712
8
37
58
11924
|
|
POL
IIEQLIKK
713
8
37
58
11925
|
|
POL
YLSWVPAII
724
8
37
58
11926
|
|
POL
LSWVPAIIK
725
8
37
58
11927
|
|
POL
YNTPVFAIK
245
9
37
58
0.0002
11928
|
|
POL
NTPVFAIKK
246
9
37
58
0.0600
11929
|
|
POL
QIIEQLIKK
712
9
37
58
0.1600
11930
|
|
POL
YLSWVPAHK
724
9
37
58
11931
|
|
POL
VIQDNSDIK
1003
9
37
58
0.0068
11932
|
|
POL
YNTPVFAIKK
245
10
37
58
11933
|
|
POL
NTPVFAIKKK
246
10
37
58
0.0046
11934
|
|
POL
VVIQDNSDIK
1002
10
37
58
0.0210
11935
|
|
POL
YNTPVFAIKKK
245
11
37
58
11936
|
|
POL
AVVIQDNSDIK
1000
11
37
58
0.0150
11937
|
|
POL
IFQSSMTK
348
8
38
59
0.0073
11938
|
|
POL
ILKEPVHGVYY
498
11
38
59
11939
|
|
POL
LDGIDKAQEEH
754
11
39
62
11940
|
|
POL
AGYVTDRGR
647
9
39
61
11941
|
|
POL
YVTDRGRQK
649
9
39
61
0.0010
11942
|
|
POL
KAGYVTDRGR
646
10
39
61
11943
|
|
POL
LGIIQAQPDK
695
10
39
61
0.0001
11944
|
|
POL
DGIDKAQEEH
755
10
39
61
11945
|
|
POL
PVHGVYYDPS
505
11
39
61
11946
|
|
POL
AGYVTDRGRQ
647
11
39
61
11947
|
|
POL
ALGIIQAQPDK
694
11
39
61
11948
|
|
POL
DIKVVPRRKAK
1009
11
39
61
11949
|
|
POL
VTDRGRQK
650
8
40
63
0.0065
11950
|
|
POL
IIQAQPDK
697
8
40
63
11951
|
|
POL
GIIQAQPDK
696
9
40
63
0.0400
11952
|
|
POL
GIDKAQEEH
756
9
40
63
11953
|
|
POL
NSDIKVVPR
1007
9
40
63
11954
|
|
POL
ILKEPVHGVY
498
10
40
63
11955
|
|
POL
DNSDIKVVPR
1006
10
40
63
11956
|
|
POL
NSDIKVVPRR
1007
10
40
63
0.0001
11957
|
|
POL
EILKEPVHGVY
497
11
40
63
11958
|
|
POL
WTYQIYQEPF
529
11
40
63
0.0540
11959
|
|
POL
QIYQEPFKNLK
532
11
40
63
0.2900
11960
|
|
POL
QDNSDIKVVPR
1005
11
40
63
11961
|
|
POL
DNSDIKVVPRR
1006
11
40
63
11962
|
|
POL
NSDIKVVPRRK
1007
11
40
63
11963
|
|
POL
ESIVIWGKTPK
570
11
41
65
11964
|
|
POL
QIYQEPFK
532
8
41
64
0.0013
11965
|
|
POL
IDKAQEEII
757
8
41
64
11966
|
|
POL
KAKIIRDY
1017
8
41
64
11967
|
|
POL
KAKIIRDYGK
1017
10
41
64
0.0018
11968
|
|
POL
KISKIGPENPY
235
11
41
64
11969
|
|
POL
KAGYVTDR
646
8
42
66
11970
|
|
POL
ISKIGPENPY
236
10
42
66
11971
|
|
POL
SMTKILEPFR
352
10
42
66
0.0004
11972
|
|
POL
SIVIWGKTPK
571
10
42
66
11973
|
|
POL
IVIYQYMDDLY
367
11
42
66
11974
|
|
POL
VVPRRKAKIIR
1012
11
42
66
11975
|
|
POL
GVYYDPSK
508
8
43
67
11976
|
|
POL
SCDKCQLK
791
8
43
67
11977
|
|
POL
MTKILIEPFR
353
9
43
67
0.0160
11978
|
|
POL
IIGVYYDPSK
507
9
43
67
0.0001
11979
|
|
POL
ASCDKCQLK
790
9
43
67
0.0040
11980
|
|
POL
DSWTVNDIQK
439
10
43
67
0.0002
11981
|
|
POL
TFYVDGAANR
631
10
43
67
0.0008
11982
|
|
POL
VASCDKCQLK
789
10
43
67
0.0004
11983
|
|
POL
KDSWTVNDIQ
438
11
43
67
11984
|
|
POL
ETFYVDGAAN
630
11
43
67
11985
|
|
POL
IVASCDKCQLK
788
11
43
67
0.1000
11986
|
|
POL
SDIKVVPR
1008
8
44
69
11987
|
|
POL
SDIKVVPRR
1008
9
44
69
0.0001
11988
|
|
POL
VDGAANRETK
634
10
44
69
11989
|
|
POL
IGQVRDQAEH
914
10
44
69
11990
|
|
POL
QVRDQAEHLK
916
10
44
69
0.0093
11991
|
|
POL
SDIKVVPRRK
1008
10
44
69
0.0001
11992
|
|
POL
ENREILKEPVII
494
11
44
69
11993
|
|
POL
YVDGAANRET
633
11
44
69
11994
|
|
POL
IIGQVRDQAEH
913
11
44
69
11995
|
|
POL
VAKEIVASCDK
784
11
45
71
11996
|
|
POL
GAANRETK
636
8
45
70
11997
|
|
POL
EIVASCDK
787
8
45
70
11998
|
|
POL
DGAANRETK
635
9
45
70
11999
|
|
POL
PFKNLKTGKY
537
10
45
70
0.0002
12000
|
|
POL
PLVKLWYQLE
613
11
45
70
12001
|
|
POL
EILKEPVH
497
8
46
72
12002
|
|
POL
KLWYQLEK
616
8
46
72
12003
|
|
POL
RDQAEIILK
918
8
46
72
12004
|
|
POL
PFKNLKTGK
537
9
46
72
12005
|
|
POL
DIQTKELQK
959
9
46
72
0.0006
12006
|
|
POL
LVKLWYQLEK
614
10
46
72
0.0820
12007
|
|
POL
KVKQWPLTEE
207
11
46
72
0.0330
12008
|
|
POL
VIWGKTPK
573
8
48
75
12009
|
|
POL
QVRDQAEII
916
8
48
75
12010
|
|
POL
DIKVVPRR
1009
8
48
75
12011
|
|
POL
IVIWGKTPK
572
9
48
75
0.3700
12012
|
|
POL
DIKVVPRRK
1009
9
48
75
0.0001
12013
|
|
POL
KVLFLDGIDK
750
10
48
75
0.7800
12014
|
|
POL
KCQLKGEAMII
794
10
48
75
12015
|
|
POL
VVESMNKELK
902
10
48
75
12016
|
|
POL
GVVESMNKEL
901
11
48
75
12017
|
|
POL
VVESMNKELK
902
11
48
75
12018
|
|
POL
GVVESMNK
901
8
49
77
12019
|
|
POL
QGVVESMNK
900
9
49
77
12020
|
|
POL
KLKPGMDGPK
197
10
49
77
0.0760
12021
|
|
POL
QSQGVVESMN
898
11
49
77
12022
|
|
POL
ESIVIWGK
570
8
50
79
12023
|
|
POL
YVDGAANR
633
8
50
78
0.0001
12024
|
|
POL
LAGRWPVK
856
8
50
78
12025
|
|
POL
KIIRDYGK
1019
8
50
78
12026
|
|
POL
KLAGRWPVK
855
9
50
78
0.0690
12027
|
|
POL
QNFRVYYRDS
973
11
50
78
12028
|
|
POL
GMDGPKVK
201
8
51
80
0.0004
12029
|
|
POL
KIGPENPY
238
8
51
80
12030
|
|
POL
NNETPGIR
325
8
51
80
12031
|
|
POL
FTTPDKKII
403
8
51
80
12032
|
|
POL
PCIMDGPKVK
200
9
51
80
0.0001
12033
|
|
POL
NNETPGIRY
325
9
51
80
12034
|
|
POL
GFTTPDKKII
402
9
51
80
12035
|
|
POL
VLFLDGIDK
751
9
51
80
0.0320
12036
|
|
POL
VIYQYMDDLY
368
10
51
80
0.0090
12037
|
|
POL
WGFTTPDKKII
401
10
51
80
12038
|
|
POL
FTTPDKKIIQK
403
10
51
80
0.0150
12039
|
|
POL
NNETPGIRYQY
325
11
51
80
12040
|
|
POL
GFTTPDKKIIQ
402
11
51
80
12041
|
|
POL
PAGLKKKK
286
8
52
81
12042
|
|
POL
SDLEIGQII
380
8
52
81
12043
|
|
POL
DLEIGQIIR
381
8
52
81
12044
|
|
POL
WGFTTPDK
401
8
52
81
12045
|
|
POL
GFTTPDKK
402
8
52
81
12046
|
|
POL
KIQNFRVY
971
8
52
81
12047
|
|
POL
VVPRRKAK
1012
8
52
81
0.0001
12048
|
|
POL
ETPGIRYQY
327
9
52
81
12049
|
|
POL
GSDLEIGQII
379
9
52
81
12050
|
|
POL
SDLEIGQIIR
380
9
52
81
0.0001
12051
|
|
POL
WGFTTPDKK
401
9
52
81
0.0039
12052
|
|
POL
KIQNFRVYY
971
9
52
81
0.1400
12053
|
|
POL
KVVPRRKAK
1011
9
52
81
0.0039
12054
|
|
POL
VGSDLEIGQH
378
10
52
81
12055
|
|
POL
GSDLEIGQHR
379
10
52
81
12056
|
|
POL
KIQNFRVYYR
971
10
52
81
0.2100
12057
|
|
POL
NFRVYYRDSR
974
10
52
81
12058
|
|
POL
IGGIGGFIKVR
134
11
52
81
12059
|
|
POL
VGPTPVNIIGR
164
11
52
81
12060
|
|
POL
YVGSDLEIGQH
377
11
52
81
12061
|
|
POL
VGSDLEIGQHR
378
11
52
81
12062
|
|
POL
GIPIIPAGLKKK
282
11
53
84
12063
|
|
POL
ICGFIKVR
137
8
53
83
12064
|
|
POL
GFIKVRQY
139
8
53
83
12065
|
|
POL
PIETVPVK
190
8
53
83
12066
|
|
POL
ETVPVKLK
192
8
53
83
0.0001
12067
|
|
POL
ELELAENR
489
8
53
83
12068
|
|
POL
QLKGEAMII
796
8
53
83
12069
|
|
POL
ESMNKELK
904
8
53
83
12070
|
|
POL
SMNKELKK
905
8
53
83
12071
|
|
POL
GIGGFIKVR
136
9
53
83
0.0005
12072
|
|
POL
GGFIKVRQY
138
9
53
83
0.0001
12073
|
|
POL
ESMNKELKK
904
9
53
83
12074
|
|
POL
GGIGGFIKVR
135
10
53
83
0.0002
12075
|
|
POL
IGGFIKVRQY
137
10
53
83
0.0002
12076
|
|
POL
ISPILTVPVK
188
10
53
83
0.0310
12077
|
|
POL
PIETVPVKLK
190
10
53
83
0.0001
12078
|
|
POL
EAELELAENR
487
10
53
83
12079
|
|
POL
LVAVIIVASGY
826
10
53
83
12080
|
|
POL
GIGGFIKVRQY
136
11
53
83
12081
|
|
POL
PISPIETVPVK
187
11
53
83
12082
|
|
POL
ILVAVIIVASGY
825
11
53
83
12083
|
|
POL
FVNIPPLVK
608
9
54
86
0.0660
12084
|
|
POL
GIPIIPAGLKK
282
10
54
86
0.1700
12085
|
|
POL
LGIPIIPAGLKK
281
11
54
86
12086
|
|
POL
QNFRVYYR
973
8
54
84
12087
|
|
POL
PTPVNIIGR
166
9
54
84
0.0001
12088
|
|
POL
LAENREILK
492
9
54
84
0.0003
12089
|
|
POL
ELAENREILK
491
10
54
84
0.0003
12090
|
|
POL
EFVNTPPLVK
607
10
54
84
12091
|
|
POL
PLTEEKIK
212
8
55
86
12092
|
|
POL
LFLDGIDK
752
8
55
86
12093
|
|
POL
GIPIIPAGLK
282
9
56
89
0.0650
12094
|
|
POL
LGIPIIPAGLK
281
10
56
89
0.0150
12095
|
|
POL
QLGIPHPAGLK
280
11
56
89
12096
|
|
POL
VTVLDVGDAY
295
10
56
88
0.0004
12097
|
|
POL
ELKKIIGQVR
909
10
56
88
12098
|
|
POL
DFWEVQLGIPII
275
11
56
88
12099
|
|
POL
SVTVLDVGDA
294
11
56
88
12100
|
|
POL
KTAVQMAVFI
925
11
56
88
12101
|
|
POL
VNTPPLVK
609
8
57
89
12102
|
|
POL
AIKKKDSTK
251
9
57
89
0.0086
12103
|
|
POL
TVLDVGDAY
296
9
57
89
0.0056
12104
|
|
POL
TTPDKKHQK
404
9
57
89
0.0042
12105
|
|
POL
FAIKKKDSTK
250
10
57
89
0.0002
12106
|
|
POL
NTPPLVKLWY
610
10
57
89
0.0002
12107
|
|
POL
AIKKKDSTKW
251
11
57
89
12108
|
|
POL
VNTPPLVKLW
609
11
57
89
12109
|
|
POL
MAVFIHNPKR
930
11
57
89
12110
|
|
POL
GGIGGYSAGER
941
11
57
89
12111
|
|
POL
KDSTKWRK
255
8
58
91
12112
|
|
POL
EVQLGIPH
278
8
58
91
12113
|
|
POL
GGNEQVDK
735
8
58
91
12114
|
|
POL
FIHINFKRK
933
8
58
91
12115
|
|
POL
GGYSAGER
944
8
58
91
12116
|
|
POL
RVYYRDSR
976
8
58
91
12117
|
|
POL
IGGNEQVDK
734
9
58
91
0.0001
12118
|
|
POL
VFIHNFKRK
932
9
58
91
0.0003
12119
|
|
POL
IGGYSAGER
943
9
58
91
0.0001
12120
|
|
POL
GIGGNEQVDK
733
10
58
91
0.0001
12121
|
|
POL
PAETGQETAY
842
10
58
91
12122
|
|
POL
AVFIHNFKRK
931
10
58
91
0.8500
12123
|
|
POL
GIGGYSAGER
942
10
58
91
0.0001
12124
|
|
POL
STKWRKLVDF
257
11
58
91
12125
|
|
POL
KGIGGNEQVDK
732
11
58
91
12126
|
|
POL
AVFIVASGY
828
8
59
92
12127
|
|
POL
ETGQETAY
844
8
59
92
12128
|
|
POL
GIWQLDCTII
811
9
59
92
12129
|
|
POL
VAVIIVASGY
827
9
59
92
0.0001
12130
|
|
POL
KGPAKLLWK
988
9
59
92
0.0007
12131
|
|
POL
EVNIVTDSQY
684
10
59
92
12132
|
|
POL
PGIWQLDCTII
810
10
59
92
12133
|
|
POL
TAVQMAVFIII
926
10
59
92
0.0110
12134
|
|
POL
VGKLNWASQI
450
11
59
92
12135
|
|
POL
NFKRKGGIGGY
936
11
59
92
12136
|
|
POL
QLDCTIILEGK
814
10
60
95
0.0003
12137
|
|
POL
DFRELNKR
265
8
60
94
12138
|
|
POL
VLDVGDAY
297
8
60
94
12139
|
|
POL
KNLKTGKY
539
8
60
94
12140
|
|
POL
VDFRLLNKR
264
9
60
94
12141
|
|
POL
MOVELIIPDK
419
9
60
94
0.0960
12142
|
|
POL
KLNWASQIY
452
9
60
94
0.0006
12143
|
|
POL
AVQMAVFIH
927
9
60
94
12144
|
|
POL
MAVFIHNFK
930
9
60
94
0.3000
12145
|
|
POL
LVDFRELNKR
263
10
60
94
12146
|
|
POL
WMGYELIIPDK
418
10
60
94
0.0004
12147
|
|
POL
QMAVFIIINFK
929
10
60
94
0.6400
12148
|
|
POL
MAVFIHNFKR
930
10
60
94
0.0083
12149
|
|
POL
KLVDFRELNK
262
11
60
94
12150
|
|
POL
QMAVFIHNFK
929
11
60
94
12151
|
|
POL
LNWASQIY
453
8
61
95
12152
|
|
POL
NDIQKLVGK
444
9
61
95
12153
|
|
POL
LDCTHLEGK
815
9
61
95
12154
|
|
POL
VNDIQKLVGK
443
10
61
95
12155
|
|
POL
TVNDIQKLVGK
442
11
61
95
0.1700
12156
|
|
POL
VDFRELNK
264
8
62
97
12157
|
|
POL
WTVNDIQK
441
8
62
97
0.0001
12158
|
|
POL
DIQKLVGK
445
8
62
97
12159
|
|
POL
NIVTDSQY
686
8
62
97
12160
|
|
POL
DCTIILEGK
816
8
62
97
12161
|
|
POL
AVFIIINFK
931
8
62
97
0.0380
12162
|
|
POL
VFIIINFKR
932
8
62
97
12163
|
|
POL
LVDFRELNK
263
9
62
97
0.0300
12164
|
|
POL
VNIVIDSQY
685
9
62
97
12165
|
|
POL
AVFIIINFKR
931
9
62
97
1.8000
12166
|
|
POL
MIGGIGGFIK
133
10
62
97
0.0550
12167
|
|
POL
KLVDFRELNK
262
10
62
97
0.0900
12168
|
|
POL
KMIGGIGGFIK
132
11
62
97
0.7000
12169
|
|
POL
NVLPQGWK
336
8
63
100
0.0012
12170
|
|
POL
IGGIGGFIK
134
9
63
98
0.0037
12171
|
|
POL
YNVLPQGWK
335
9
63
98
0.0001
12172
|
|
POL
GGIGGFIK
135
8
64
100
12173
|
|
POL
FLWMGYELII
416
9
64
100
12174
|
|
POL
PFLWMGYELII
415
10
64
100
12175
|
|
REV
GTRQTRKNR
37
9
01
50
12176
|
|
REV
TTRQARRNR
37
9
01
50
12177
|
|
REV
GTRQTRKNRR
37
10
01
50
12178
|
|
REV
TTRQARRNRR
37
10
01
50
12179
|
|
REV
GTRQTRKNRR
37
11
01
50
12180
|
|
REV
TTRQARRNRR
37
11
01
50
12181
|
|
REV
GTETGVGR
103
8
06
19
12182
|
|
REV
QGTETGVGR
102
9
06
19
12183
|
|
REV
LLKTVRLIK
12
9
10
16
12184
|
|
REV
GDSDEELLK
6
9
11
17
12185
|
|
REV
PLQLPPIER
76
9
11
17
12186
|
|
REV
SGDSDEELLK
5
10
11
17
12187
|
|
REV
RSGDSDEELLK
4
11
11
17
12188
|
|
REV
PVPLQLPPIER
74
11
11
17
12189
|
|
REV
RARQRQIR
50
8
12
19
121911
|
|
REV
DSDEELLK
7
8
12
19
12191
|
|
REV
ILSTCLGR
63
8
12
19
12192
|
|
REV
RILSTCLGR
62
9
12
19
12193
|
|
REV
SNPPPSPEGTR
27
11
12
19
12194
|
|
REV
AVRIIKILY
17
9
13
20
12195
|
|
REV
QLPPLERLH
78
9
13
20
12196
|
|
REV
PSPEGTRQAR
31
10
13
20
12197
|
|
REV
RNRRRRWRER
43
10
13
20
12198
|
|
REV
PSPEGTRQAR
31
11
13
20
12199
|
|
REV
PLQLPPLERLH
76
11
13
20
12200
|
|
REV
GTRQARKNRR
36
11
14
22
12201
|
|
REV
RARQRQIII
50
8
15
24
12202
|
|
REV
GTRQARKNR
36
9
15
23
12203
|
|
REV
GTRQARKNRR
36
10
15
23
12204
|
|
REV
QARKNRRRR
40
9
16
25
12205
|
|
REV
QARKNRRRR
40
11
16
25
12206
|
|
REV
QARKNRRR
40
8
17
27
12207
|
|
REV
IIKILYQSNPY
20
11
18
28
12208
|
|
REV
KNRRRRWRA
43
10
19
30
12209
|
|
REV
KNRRRRWR
43
8
21
33
12210
|
|
REV
RNRRRRWRA
43
10
23
36
12211
|
|
REV
KILYQSNPY
22
9
26
41
12212
|
|
REV
ILYQSNPY
23
8
27
42
12213
|
|
REV
EGTRQARR
35
8
27
42
12214
|
|
REV
EGTRQARRNR
35
10
27
42
12215
|
|
REV
EGTRQARRNR
35
11
27
42
12216
|
|
REV
GTRQARRNR
36
9
34
53
12217
|
|
REV
GTRQARRNRR
36
10
34
53
12218
|
|
REV
GTRQARRNRR
36
11
34
53
12219
|
|
REV
PVPLQLPPLER
74
11
34
53
12220
|
|
REV
PLQLPPLER
76
9
35
55
12221
|
|
REV
QARRNRRRR
40
11
37
58
12222
|
|
REV
QARRNRRR
40
8
38
59
12223
|
|
REV
QARRNRRRR
40
9
38
59
12224
|
|
REV
RNRRRRWR
43
8
40
63
12225
|
|
TAT
PCGYPRRK
104
8
01
50
12226
|
|
TAT
AGPGGYPRR
102
9
01
50
12227
|
|
TAT
TGPSGQPCII
102
9
01
50
12228
|
|
TAT
ETGIPSGQPCII
101
10
01
50
12229
|
|
TAT
KAGPGGYPRR
101
10
01
50
12230
|
|
TAT
AGPGGYPRRK
102
10
01
50
12231
|
|
TAT
KAGPGGYPRR
101
11
01
50
12232
|
|
TAT
GGYPRRKGSC
105
11
01
50
12233
|
|
TAT
ACTNCYCK
24
8
10
16
12234
|
|
TAT
TACTNCYCK
23
9
10
16
12235
|
|
TAT
CNNCYCKK
25
8
11
17
12236
|
|
TAT
YCKKCCFII
29
8
11
17
12237
|
|
TAT
YCKKCCYH
29
8
11
17
12238
|
|
TAT
VDPRLEPWK
4
9
11
17
12239
|
|
TAT
ACNNCYCKK
24
9
11
17
12240
|
|
TAT
PVDPRLEPWK
3
10
11
17
0.0001
12241
|
|
TAT
VDPRLEPWKH
4
10
11
17
12242
|
|
TAT
TACNNCYCKK
23
10
11
17
12243
|
|
TAT
PVDPRLEPWK
3
11
11
17
12244
|
|
TAT
RGDPTGPKES
84
11
11
17
12245
|
|
TAT
GDPTGPKESK
85
11
11
17
12246
|
|
TAT
ESKKKVESK
93
9
12
19
12247
|
|
TAT
GDPTGPKESK
85
10
12
19
12248
|
|
TAT
PTGPKESKKK
88
10
12
19
12249
|
|
TAT
TGPKESKKK
89
9
13
20
12250
|
|
TAT
LNKGLGISY
42
9
14
22
12251
|
|
TAT
FLNKGLGISY
41
10
14
22
12252
|
|
TAT
PVDPNLEPWN
3
11
14
22
12253
|
|
TAT
CFLNKGLGISY
40
11
14
22
12254
|
|
TAT
LNKGLGISYGR
42
11
14
22
12255
|
|
TAT
WNHPGSQPK
14
9
15
23
12256
|
|
TAT
RGDPTGPK
84
8
16
25
12257
|
|
TAT
VDPNLEPWNH
4
10
16
25
12258
|
|
TAT
PNLEPWNH
9
8
17
27
12259
|
|
TAT
ACNNCYCK
24
8
17
27
12260
|
|
TAT
TACNNCYCK
23
9
17
27
12261
|
|
TAT
PTGPKESKK
88
9
18
28
12262
|
|
TAT
TGPKESKK
89
8
19
30
12263
|
|
TAT
PTGPKESK
88
8
20
31
12264
|
|
TAT
YGRKKRRQRR
50
11
22
34
12265
|
|
TAT
YGRKKRRQRR
50
10
38
59
12266
|
|
TAT
ISYGRKKRRQR
48
11
39
61
12267
|
|
TAT
YGRKKRRQR
50
9
41
64
12268
|
|
TAT
GISYGRKKRR
47
10
45
70
0.0001
12269
|
|
TAT
LGISYGRKKRR
46
11
45
70
12270
|
|
TAT
ISYGRKKRR
48
9
46
72
0.0005
12271
|
|
TAT
GLGISYGRKKR
45
11
54
86
12272
|
|
TAT
GLGISYGR
45
8
55
87
12273
|
|
TAT
GLGISYGRK
45
9
55
87
0.0006
12274
|
|
TAT
GLGISYGRKK
45
10
55
87
12275
|
|
TAT
KGLGISYGR
44
9
55
86
0.0180
12276
|
|
TAT
KGLGISYGRK
44
10
55
86
0.0007
12277
|
|
TAT
KGLGISYGRKK
44
11
55
86
12278
|
|
TAT
GISYGRKKR
47
9
57
89
0.0005
12279
|
|
TAT
LGISYGRKKR
46
10
57
89
12280
|
|
TAT
LGISYGRK
46
8
58
91
12281
|
|
TAT
GISYGRKK
47
8
58
91
12282
|
|
TAT
ISYGRKKR
48
8
58
91
12283
|
|
TAT
LGISYGRKK
46
9
58
91
0.0005
12284
|
|
VIF
LIVWQVDR
8
8
10
16
12285
|
|
VIF
RMRINTWK
15
8
10
16
12286
|
|
VIF
LIKPKKIK
158
8
10
16
12287
|
|
VIF
KGWPYRIIIIY
36
9
10
16
12288
|
|
VIF
ALIKPKKIK
157
9
10
16
12289
|
|
VIF
VDRMRINTWK
13
10
10
16
12290
|
|
VIF
GVSIEWRLRR
87
10
10
16
12291
|
|
VIF
QVDRMRINTW
12
11
10
16
12292
|
|
VIF
RLVITTYWGL
65
11
10
16
12293
|
|
VIF
QTGERDWIILG
75
11
10
16
12294
|
|
VIF
GVSIEWRLRR
87
11
10
16
12295
|
|
VIF
IDPDLADQLIII
103
11
10
16
12296
|
|
VIF
LVEDRWNKPQ
178
11
10
16
12297
|
|
VIF
SIEWRLRR
89
8
11
17
12298
|
|
VIF
TALIKPKK
156
8
11
17
12299
|
|
VIF
LVEDRWNK
178
8
11
17
12300
|
|
VIF
VSIEWRLRR
88
9
11
17
12301
|
|
VIF
SIEWRLRRY
89
9
11
17
12302
|
|
VIF
LTALIKPKK
155
9
11
17
12303
|
|
VIF
KLVEDRWNK
177
9
11
17
12304
|
|
VIF
VSIEWRLRRY
88
10
11
17
12305
|
|
VIF
GLADQLIHMH
106
10
11
17
12306
|
|
VIF
ALTALIKPKK
134
10
11
17
12307
|
|
VIF
WNKPQKTRGH
183
10
11
17
12308
|
|
VIF
PGLADQLIHMH
105
11
11
17
12309
|
|
VIF
GLADQLIHMH
106
11
11
17
12310
|
|
VIF
LALTALIKPKK
153
11
11
17
12311
|
|
VIF
WNKPQKTRGH
183
11
11
17
12312
|
|
VIF
WPYRIIIIYESR
38
11
12
19
12313
|
|
VIF
KGWFYRIIII
36
8
12
19
12314
|
|
VIF
WGLQIGER
72
8
12
19
12315
|
|
VIF
QTGERDWII
75
8
12
19
12316
|
|
VIF
IVWQVDRMK
9
9
12
19
12317
|
|
VIF
KIRTWNSLVK
17
10
12
19
12318
|
|
VIF
LVKIIHMYVSK
24
10
12
19
12319
|
|
VIF
GLQTGERDWH
73
10
12
19
12320
|
|
VIF
TGERDWHLGH
77
10
12
19
12321
|
|
VIF
HGVSIEWRLR
86
10
12
19
12322
|
|
VIF
IVWQVDRMKI
9
11
12
19
12323
|
|
VIF
KIRTWNSLVK
17
11
12
19
12324
|
|
VIF
SLVKIIHMYVS
23
11
12
19
12325
|
|
VIF
LVKHIIMYVSK
24
11
12
19
12326
|
|
VIF
WGLQTGERD
72
11
12
19
12327
|
|
VIF
WPYRIIIIYESR
38
10
13
21
12328
|
|
VIF
QVDRMKIR
12
8
13
20
12329
|
|
VIF
HIPLGDAR
56
8
13
20
12330
|
|
VIF
ADQLIIIMII
108
8
13
20
12331
|
|
VIF
CFSDSAIR
119
8
13
20
12332
|
|
VIF
FSDSAIRK
120
8
13
20
12333
|
|
VIF
SLQYLALK
149
8
13
20
12334
|
|
VIF
LTALIKPK
155
8
13
20
12335
|
|
VIF
LADQLIIIMH
107
9
13
20
12336
|
|
VIF
ADQLIIIMHY
108
9
13
20
12337
|
|
VIF
CFSDSAIRK
119
9
13
20
12338
|
|
VIF
GSLQYLALK
148
9
13
20
12339
|
|
VIF
ALTALIKPK
154
9
13
20
12340
|
|
VIF
SVKKLTEDR
174
9
13
20
12341
|
|
VIF
EVHIPLGDAR
54
10
13
20
12342
|
|
VIF
LADQLIIIMHY
107
10
13
20
12343
|
|
VIF
DCFSESAIRK
118
10
13
20
12344
|
|
VIF
VGSLQYLALK
147
10
13
20
12345
|
|
VIF
LALTALIKPK
153
10
13
20
12346
|
|
VIF
PSVKKLTEDR
173
10
13
20
12347
|
|
VIF
FDCFSESAIRK
117
11
13
20
12348
|
|
VIF
YLALTALIKPK
152
11
13
20
12349
|
|
VIF
FSESAIRK
120
8
14
22
12350
|
|
VIF
IVSPRCEY
133
8
14
22
12351
|
|
VIF
GVSIEWRLR
87
9
14
22
12352
|
|
VIF
ADQLIIILYY
108
9
14
22
12353
|
|
VIF
CFSESAIRK
119
9
14
22
12354
|
|
VIF
VDRMRIRTWK
13
10
14
22
12355
|
|
VIF
LADQLIHLYY
107
10
14
22
12356
|
|
VIF
RCDYQAGHNK
137
10
14
22
12357
|
|
VIF
QVDRMRIRTW
12
11
14
22
12358
|
|
VIF
RIRTWNSLVK
17
11
14
22
12359
|
|
VIF
RMRIRTWK
15
8
15
23
12360
|
|
VIF
RTWKSLVK
19
8
15
23
12361
|
|
VIF
VSIEWRLR
88
8
15
23
12362
|
|
VIF
ADQLIIILY
108
8
15
23
12363
|
|
VIF
RTWKSLVKH
19
9
15
23
12364
|
|
VIF
QGVSIEWRK
86
9
15
23
12365
|
|
VIF
LADQLIHLY
107
9
15
23
12366
|
|
VIF
AIRKAILGII
124
9
15
23
12367
|
|
VIF
CDYQAGHNK
138
9
15
23
12368
|
|
VIF
RIRTWKSLVK
17
10
15
23
12369
|
|
VIF
RIRTWNSLVK
17
10
15
23
12370
|
|
VIF
RTWKSLVKHH
19
10
15
23
12371
|
|
VIF
SAIRKAILGH
123
10
15
23
12372
|
|
VIF
RIRTWKSLVK
17
11
15
23
12373
|
|
VIF
LGQGVSIEWR
84
11
15
23
12374
|
|
VIF
VDPGLADQLIH
103
11
15
23
12375
|
|
VIF
ITTYWGLII
68
8
16
25
12376
|
|
VIF
GVSIEWRK
87
8
16
25
12377
|
|
VIF
RCDYQAGII
137
8
16
25
12378
|
|
VIF
LALIALIK
153
8
16
25
12379
|
|
VIF
VITTYWGLH
67
9
16
25
12380
|
|
VIF
YLALTALIK
152
9
16
25
12381
|
|
VIF
KTKGIIRGSII
188
9
16
25
0.0001
12382
|
|
VIF
LVITTYWGLII
66
10
16
25
12383
|
|
VIF
WNKPQKTKGII
183
10
16
25
12384
|
|
VIF
WNKPQKTKGH
183
11
16
25
12385
|
|
VIF
EDRWNKPQKT
180
11
17
27
12386
|
|
VIF
WNKPQKTK
183
8
18
28
12387
|
|
VIF
KSLVKIIHMY
22
9
18
28
12388
|
|
VIF
EDRWNKPQKT
180
11
18
28
12389
|
|
VIF
RCEYQAGIINK
137
10
19
30
12390
|
|
VIF
HIPLGEAR
56
8
20
31
12391
|
|
VIF
WNKPQKTR
183
8
20
31
12392
|
|
VIF
EVIIIPLGEAR
54
10
20
31
12393
|
|
VIF
IITGERDWII
75
8
21
33
12394
|
|
VIF
DLADQLIH
106
8
21
33
12395
|
|
VIF
PDLADQLIH
105
9
21
33
12396
|
|
VIF
GLIITGERDWII
73
10
21
33
12397
|
|
VIF
WGLIITGERD
72
11
21
33
12398
|
|
VIF
VSPRCEYQAG
134
11
21
33
12399
|
|
VIF
LTEDRWNKPQ
178
11
21
33
0.0130
12400
|
|
VIF
GSHTMNGII
194
8
22
34
12401
|
|
VIF
RGSHTMNGH
193
9
22
34
12402
|
|
VIF
TTYWGLHTGE
69
11
22
34
12403
|
|
VIF
HLGHGVSIEW
83
11
22
34
12404
|
|
VIF
NSLVKIIHMY
22
9
24
38
12405
|
|
VIF
WNSLVKHHM
21
10
24
38
12406
|
|
VIF
QGVSIEWR
86
8
25
39
12407
|
|
VIF
LGQGVSIEWR
84
10
25
39
12408
|
|
VIF
HLGQGVSIEW
83
11
25
39
12409
|
|
VIF
RCEYQAGH
137
8
26
41
12410
|
|
VIF
RTWNSLVKH
19
9
26
41
12411
|
|
VIF
RTWNSLVKHH
19
10
26
41
12412
|
|
VIF
RTWNSLVK
19
8
27
42
12413
|
|
VIF
IIGVSIEWR
86
8
27
42
12414
|
|
VIF
GLADQLIH
106
8
27
42
12415
|
|
VIF
PGLADQLIH
105
9
27
42
12416
|
|
VIF
LGHGVSIEWR
84
10
27
42
12417
|
|
VIF
YPDCPSESAIR
116
11
27
42
12418
|
|
VIF
WGLIITGER
72
8
28
44
12419
|
|
VIF
DCPSESAIR
118
9
28
44
12420
|
|
VIF
FDCFSESAIR
117
10
28
44
12421
|
|
VIF
WNSLVKIIII
21
8
29
45
12422
|
|
VIF
CPSESAIR
119
8
29
45
12423
|
|
VIF
KLTEDRWNK
177
9
29
45
0.2700
12424
|
|
VIF
LTEDRWNK
178
8
31
48
0.0045
12425
|
|
VIF
IVWQVDRMRI
9
11
33
52
12426
|
|
VIF
QVDRMRIR
12
8
34
53
12427
|
|
VIF
EDRWNKPQK
180
9
39
61
12428
|
|
VIF
VMIVWQVDR
7
11
41
64
12429
|
|
VIF
QVMIVWQVDR
6
10
43
67
12430
|
|
VIF
MIVWQVDRM
8
10
43
67
0.0001
12431
|
|
VIF
AGIINKVGSLQ
142
11
43
67
12432
|
|
VIF
SLVKIIIIMY
23
8
44
69
12433
|
|
VIF
VMIVWQVDR
7
9
44
69
0.0220
12434
|
|
VIF
MIVWQVDR
8
8
46
72
12435
|
|
VIF
IVWQVDRMR
9
9
47
73
0.0007
12436
|
|
VIF
IINKVGSLQY
144
9
47
73
12437
|
|
VPR
#LPGRRGR
85
8
01
50
12438
|
|
VPR
NIRGRRVR
85
8
01
50
12439
|
|
VPR
WALELLEELK
18
10
09
15
12440
|
|
VPR
QLLPVHFR
66
8
10
16
12441
|
|
VPR
HSRIGIIR
79
8
10
16
12442
|
|
VPR
RIGITRQR
81
8
10
16
12443
|
|
VPR
IGITRQRR
82
8
10
16
12444
|
|
VPR
ALELLEELK
19
9
10
16
12445
|
|
VPR
RIGITRQRR
81
9
10
16
12446
|
|
VPR
HSRIGITRQR
79
10
10
16
12447
|
|
VPR
HSRIGITRQRR
79
11
10
16
12448
|
|
VPR
WLHGLGQY
38
8
11
17
12449
|
|
VPR
HFRIGCRH
71
8
11
17
12450
|
|
VPR
HSRIGITR
79
8
11
17
12451
|
|
VPR
FIHFRIGCR
69
9
11
17
12452
|
|
VPR
LFIHFRIGCR
68
10
11
17
12453
|
|
VPR
FIHFRIGCRH
69
10
11
17
12454
|
|
VPR
FVHFRIGCQH
69
10
11
17
12453
|
|
VPR
HFRIGCRHSR
71
10
11
17
12456
|
|
VPR
LLFIHFRIGCR
67
11
11
17
12457
|
|
VPR
LFIHFRIGCRH
68
11
11
17
12458
|
|
VPR
LFVIIFRIGCQII
68
11
11
17
12459
|
|
VPR
RIGCRIISR
74
8
12
19
12460
|
|
VPR
LGQIIIYNTY
42
9
13
20
12461
|
|
VPR
LGQYIYETY
42
9
13
20
12462
|
|
VPR
IIFPRIWLII
33
8
14
22
12463
|
|
VPR
KSEAVRHFPR
27
10
14
22
12464
|
|
VPR
AVRIIFPRIWL
30
11
14
22
12465
|
|
VPR
ELKSEAVR
25
8
16
25
12466
|
|
VPR
AGVEAIIR
55
8
16
25
12467
|
|
VPR
ELKSEAVRH
25
9
16
25
12468
|
|
VPR
WAGVEAIIR
54
9
16
25
12469
|
|
VPR
LLEELKSEAVR
22
11
16
25
12470
|
|
VPR
DTWAGVEAIIR
52
11
16
25
12471
|
|
VPR
ELKNEAVR
25
8
17
27
12472
|
|
VPR
ELKNEAVRH
25
9
17
27
12473
|
|
VPR
LGQIIIYETY
42
9
17
27
12474
|
|
VPR
LLEELKNEAVR
22
11
17
27
12475
|
|
VPR
EGVEAIIR
55
8
18
28
12476
|
|
VPR
DTWEGVEAIIR
52
11
18
28
12477
|
|
VPR
RARNGASR
93
8
19
30
12478
|
|
VPR
KNEAVRIIFPR
27
10
19
30
12479
|
|
VPR
WLIIGLGQH
38
8
20
31
12480
|
|
VPR
HGLGQIIIY
40
8
20
31
12481
|
|
VPR
WLHGLGQIIIY
38
10
20
31
12482
|
|
VPR
LFIIIFRIGCQH
68
11
29
45
12483
|
|
VPR
FIIIFRIGCQH
69
10
30
47
12484
|
|
VPR
IIFPRPWLH
33
8
31
49
12485
|
|
VPR
AVRHFPRPWL
30
11
31
48
12486
|
|
VPR
ILQQLLFIHFR
63
11
35
55
12487
|
|
VPR
RILQQLLFIIH
62
10
36
56
12488
|
|
VPR
ILQQLLFIH
63
9
37
58
12489
|
|
VPR
EDQGPQREPY
6
10
37
58
12490
|
|
VPR
QAPEDQGPQR
3
10
39
62
12491
|
|
VPR
WTLELLEELK
18
10
42
69
12492
|
|
VPR
QGPQREPY
8
8
43
68
12493
|
|
VPR
QLLFIHFR
66
8
44
69
12494
|
|
VPR
FIFRIGCQII
71
8
44
69
12495
|
|
VPR
TLELLEELK
19
9
44
69
12496
|
|
VPR
IIFRIGCQHSR
71
10
44
69
12497
|
|
VPR
RIGCQIISR
74
8
47
73
12498
|
|
VPR
EAVRIIFPR
29
8
59
92
12499
|
|
VPU
LVQRKQDR
43
8
01
50
12500
|
|
VPU
VTLLSSSK
94
8
01
50
12501
|
|
VPU
LVQRKQDRR
43
9
01
50
12502
|
|
VPU
LVTLLSSSK
91
9
01
50
12503
|
|
VPU
RIKEIRDDSDY
64
11
01
50
12504
|
|
VPU
RIREIRDDSDY
64
11
01
50
12505
|
|
VPU
WTIVFIEYR
34
9
10
16
12506
|
|
VPU
TIVFIEYR
35
8
10
16
12507
|
|
VPU
IDRLIDRIR
54
9
10
16
12508
|
|
VPU
RLIDRIRER
56
9
10
16
12509
|
|
VPU
KIDRLIDRIR
52
10
10
16
12510
|
|
VPU
VVWTIVFIEYR
31
11
10
16
12511
|
|
VPU
WTIVFIEY
34
8
12
19
12512
|
|
VPU
IVFIEYRK
36
8
12
19
12513
|
|
VPU
VVWTIVFIEY
31
10
12
19
12514
|
|
VPU
IVVWTIVFIEY
30
11
12
19
12515
|
|
VPU
LlDRIRER
58
8
14
22
12516
|
|
VPU
KIDRLIDR
52
8
15
23
12517
|
|
VPU
ILRQRKIDR
46
9
15
23
12518
|
|
VPU
KILRQRKIDR
45
10
15
23
0.0001
12519
|
|
TABLE XVIII
|
|
|
HIV A24 Motif Peptides with Binding Information
|
No. of
Sequence
Conservancy
|
Protein
Sequence
Position
Amino Acids
Frequency
(%)
A*2401
SEQ ID NO.
|
|
ENV
IIMLQLTVW
650
8
10
16
12520
|
|
ENV
WFDITNWL
767
8
10
16
12521
|
|
ENV
WFDITNWLW
767
9
10
16
12522
|
|
ENV
IIYCTPAGFAI
262
10
10
16
12523
|
|
ENV
IWNNMTWME
717
10
10
16
12524
|
|
ENV
WFDITNWLW
767
11
10
16
12525
|
|
ENV
SYIIRLRDLLLI
864
11
10
16
12526
|
|
ENV
HYCTPAGF
262
8
11
17
12527
|
|
ENV
FYATGDIIGDI
367
11
11
17
12528
|
|
ENV
FYATGDII
367
8
12
19
12529
|
|
ENV
WMEWEREI
723
8
12
19
12530
|
|
ENV
GWEALKYL
896
8
12
19
12531
|
|
ENV
GWEGLKYL
896
8
12
19
12532
|
|
ENV
TWMEWEREI
722
9
12
19
12533
|
|
ENV
SYIIRLRDLLL
864
10
12
19
12534
|
|
ENV
NMTWMEWER
720
11
12
19
12535
|
|
ENV
YWGQELKNSA
909
11
12
19
12536
|
|
ENV
LYKYKVVEI
569
9
13
20
12537
|
|
ENV
SYIIRLRDFI
864
9
13
20
12538
|
|
ENV
SYIIRLRDFIL
864
10
13
20
12539
|
|
ENV
VMIISFNCGGE
432
11
13
20
12540
|
|
ENV
LFSYIIRLRDFI
862
11
13
20
12541
|
|
ENV
LFSYIIRLRDLL
862
11
13
20
12542
|
|
ENV
SYFIRLRDLL
864
9
14
22
12543
|
|
ENV
KYWWNLLQY
909
10
14
22
12544
|
|
ENV
WWNLLQYW
903
8
15
23
12545
|
|
ENV
YWWNLLQYW
902
9
15
23
12546
|
|
ENV
KWASLWNWF
760
11
15
23
12547
|
|
ENV
SFNCRGEF
437
8
16
25
12548
|
|
ENV
SFNCRGIFF
437
9
16
25
12549
|
|
ENV
KWLWYIKIF
772
9
16
25
12550
|
|
ENV
KWLWYIKIFI
772
10
16
25
12551
|
|
ENV
RYLRDQQLL
671
9
17
27
0.2300
12552
|
|
ENV
RYLRDQQLLGI
671
11
17
27
12553
|
|
ENV
RYLRDQQL
671
8
18
28
12554
|
|
ENV
SYIIRLRDF
864
8
18
28
12555
|
|
ENV
AYDTEVHNVW
73
10
18
28
12556
|
|
ENV
LFSYIIRLRDF
862
10
18
28
12557
|
|
ENV
KWLWYIKI
772
8
19
30
12558
|
|
ENV
AWDDLRSL
853
8
20
31
12559
|
|
ENV
NMVEQMHEDI
112
10
20
31
0.0004
12560
|
|
ENV
AWDDLRSLCL
853
10
20
31
12569
|
|
ENV
NMVEQMIIEDII
112
11
20
31
12562
|
|
ENV
AWDDLRSLCL
853
11
20
31
12563
|
|
ENV
FYCNTSGL
445
8
21
33
12564
|
|
ENV
FFYCNTSGL
444
9
21
33
12565
|
|
ENV
FYCNTSGLF
445
9
21
33
12566
|
|
ENV
EFFYCNTSGL
443
10
21
33
12567
|
|
ENV
FFYCNTSGLF
444
10
21
33
12568
|
|
ENV
EFFYCNTSGLF
443
11
21
33
12569
|
|
ENV
VWKEATTTL
55
9
22
34
0.0300
12570
|
|
ENV
VWKEATITLF
55
10
22
34
0.2700
12571
|
|
ENV
LFSYIIRLRDL
862
10
22
34
12572
|
|
ENV
SYIIRLRDL
864
8
23
36
12573
|
|
ENV
NWLWYIKI
772
8
25
39
12574
|
|
ENV
NWLWYIKIF
772
9
25
39
12575
|
|
ENV
KYKVVKIEPL
563
10
25
39
12576
|
|
ENV
NWLWYIKIFI
772
10
25
39
12577
|
|
ENV
GFLALAWDDL
848
10
25
39
12578
|
|
ENV
RYLKDQQLLGI
671
11
25
39
12579
|
|
ENV
KWASLWNW
760
8
26
41
12580
|
|
ENV
KWASLWNWF
760
9
26
41
12581
|
|
ENV
IIYCAPAGF
262
8
27
42
12582
|
|
ENV
IIYCAPAGFAI
262
10
27
42
12583
|
|
ENV
IIYCAPAGFAIL
262
11
27
42
12584
|
|
ENV
QMIIEDIISL
116
9
29
45
12585
|
|
ENV
LYKYKVVKI
561
9
29
45
0.0200
12586
|
|
ENV
RYLKDQQLL
671
9
29
45
0.7600
12587
|
|
ENV
QMHEDIISLW
116
10
29
45
12588
|
|
ENV
GYSPLSFQTL
806
10
29
45
12589
|
|
ENV
RYLKDQQL
671
8
30
47
12590
|
|
ENV
IFIMIVGGLI
779
10
33
52
12591
|
|
ENV
IMIVGGLIGL
781
10
34
54
12592
|
|
ENV
IMIYGGLI
781
8
35
56
12593
|
|
ENV
SPNCGGEFF
437
9
35
55
12594
|
|
ENV
SPNCGGEF
437
8
36
56
12595
|
|
ENV
DMRDNWRSEL
552
10
37
58
12596
|
|
ENV
TMGAASITL
615
9
39
61
12597
|
|
ENV
IFIMIVGGL
779
9
41
64
12598
|
|
ENV
WYIKIFIMI
775
9
43
67
12599
|
|
ENV
LWYIKIFIMI
774
10
43
67
12600
|
|
ENV
IWGCSGKL
681
8
48
75
12601
|
|
ENV
IWGCSGKLI
681
9
48
75
0.0270
12602
|
|
ENV
LWYIKIFI
774
8
49
77
12603
|
|
ENV
VYYGVPVW
49
8
55
86
12604
|
|
GAG
LYPLASLKSL
544
10
09
17
12605
|
|
GAG
LYPLASLKSLF
544
11
09
17
12606
|
|
GAG
KYKLKIIIVW
29
9
10
16
12607
|
|
GAG
GWMTSNPPI
269
9
10
16
12608
|
|
GAG
IMMQKSNF
408
8
11
17
12609
|
|
GAG
LYCVIIQKI
87
8
13
20
12610
|
|
GAG
MYSPTSILDI
300
10
13
20
12611
|
|
GAG
RMYSPTSILDI
299
11
13
20
12612
|
|
GAG
RMYSPTSI
299
8
14
22
12613
|
|
GAG
MYSPTSIL
300
8
14
22
12614
|
|
GAG
RMYSPTSIL
299
9
14
22
12615
|
|
GAG
RFAVNPGL
45
8
16
25
12616
|
|
GAG
LFNTVATL
80
8
16
25
12617
|
|
GAG
WMTSNPPI
270
8
16
25
12618
|
|
GAG
NWMTDTLL
339
8
16
25
12619
|
|
GAG
KYRLKHLVW
29
9
16
25
12620
|
|
GAG
RFAVPGLL
45
9
16
25
0.0100
12621
|
|
GAG
LYCVIIQRI
87
8
18
28
12622
|
|
GAG
GWMTNNPPI
269
9
18
28
0.0140
12623
|
|
GAG
RFALNPGL
45
8
20
31
12624
|
|
GAG
WMTNNPPI
270
8
20
31
12625
|
|
GAG
RFALNPGLL
45
9
20
31
12626
|
|
GAG
LYNTVATL
80
8
22
34
12627
|
|
GAG
AWVKVIEEKA
175
11
24
38
12628
|
|
GAG
AMQMLKETI
218
9
26
41
12629
|
|
GAG
IMMQRGNF
408
8
27
42
12630
|
|
GAG
DYVDRFFKTL
319
10
27
42
12631
|
|
GAG
CFNCGKEGIII
425
10
27
42
12632
|
|
GAG
CFNCGKEGIIL
425
10
27
42
12633
|
|
GAG
DYVDRFYKTL
319
10
28
44
0.0010
12634
|
|
GAG
AWVKVVEEKA
175
11
28
44
12635
|
|
GAG
NYPIVQNL
152
8
31
48
12636
|
|
GAG
AMQMLKDTI
218
9
33
52
12637
|
|
GAG
PFRDYVDRFF
316
10
35
55
12638
|
|
GAG
NWMTETLL
339
8
36
56
12639
|
|
GAG
RMYSPVSILDI
299
11
38
59
12640
|
|
GAG
RMYSPVSI
299
8
40
63
12641
|
|
GAG
RMYSPVSIL
299
9
40
63
12642
|
|
GAG
MYSPVSILDI
300
10
40
63
12643
|
|
GAG
MYSPYSIL
300
8
42
66
12644
|
|
GAG
QMREPRGSDI
248
10
44
69
12645
|
|
GAG
VWASRELERF
36
10
45
70
12646
|
|
GAG
AFSPEVIPMF
184
10
50
78
0.0078
12647
|
|
GAG
IYKRWIIL
285
8
54
84
12648
|
|
GAG
IYKRWIILGL
285
10
54
84
0.0140
12649
|
|
GAG
RWIILGLNKI
288
10
56
88
12650
|
|
GAG
PFRDYVDRF
316
9
63
98
12651
|
|
NEF
PMTYKGAF
105
8
12
19
12652
|
|
NEF
TYKGAFDL
107
8
12
19
12653
|
|
NEF
PMTYKGAFDL
105
10
12
19
12654
|
|
NEF
VYIITQGFF
192
8
13
20
12655
|
|
NEF
LWVYIITQGF
190
9
13
20
12656
|
|
NEF
LWVYIITQGFF 190
10
13
20
12657
|
|
NEF
NYTPGPGTRF
206
10
13
20
12658
|
|
NEF
VYIITQGFFPD
192
11
13
20
12659
|
|
NEF
RFPLTFGWCF
216
10
17
27
12660
|
|
NEF
IYSKKRQEI
175
9
18
29
12661
|
|
NEF
IYSKKRQEIL
175
10
18
29
12662
|
|
NEF
AFDLSFFL
111
8
18
28
12663
|
|
NEF
DWQNYTPGPG
203
11
18
28
12664
|
|
NEF
RFPLTFGW
216
8
20
32
12665
|
|
NEF
NYTPGPGI
206
8
20
31
12666
|
|
NEF
KWSKSSIVGW
4
10
20
31
12667
|
|
NEF
RYPLTFGWCF
216
10
21
33
12668
|
|
NEF
VYHTQGYF
192
8
21
33
12669
|
|
NEF
LWVYIITQGYF
190
10
21
33
12670
|
|
NEF
VYIITQGYFPD
192
11
21
33
12671
|
|
NEF
SFFLKEKGGL
115
10
22
34
12672
|
|
NEF
FFLKEKGGL
116
9
26
41
12673
|
|
NEF
RYPLTFGW
216
8
27
43
12674
|
|
NEF
HFLKEKGCL
116
9
29
45
12675
|
|
NEF
TFGWCFKL
222
8
40
63
12676
|
|
NEF
GFPVRPQVPL
93
10
48
75
12677
|
|
POL
AFPQGEAREF
7
10
10
16
12678
|
|
POL
NMLTQLGCTL
175
10
10
16
12679
|
|
POL
TWETWWTDY
589
10
10
16
12680
|
|
POL
TWWTDYWQA
592
11
10
16
12681
|
|
POL
CWWAGIQQEF
882
10
11
17
12682
|
|
POL
IWGKIPKF
574
8
11
17
12683
|
|
POL
WYQLETEPI
618
9
11
17
12684
|
|
POL
WWAGIQQEF
883
9
11
17
12685
|
|
POL
IYPGIKVKQL
459
10
11
17
12686
|
|
POL
LWYQLETEPI
617
10
11
17
12687
|
|
POL
WWAGIQQEFG
883
11
11
17
12688
|
|
POL
QYDQIPIEI
145
9
12
19
12689
|
|
POL
KWTVQPIVL
427
9
12
19
12690
|
|
POL
LWQRPLVTVK
92
11
12
19
12691
|
|
POL
TWWTEYWQA
592
11
12
19
12692
|
|
POL
SFSFPQITLW
84
10
13
20
12693
|
|
POL
SFSFPQITL
84
9
14
22
12694
|
|
POL
WYQLIEKDPI
618
9
14
22
12695
|
|
POL
YYRDSRDPL
978
9
14
22
12696
|
|
POL
WWTDYWQAT
593
10
14
22
12697
|
|
POL
LWYQLEKDPI
617
10
14
22
12698
|
|
POL
VYYRDSRDPL
977
10
14
22
12699
|
|
POL
YYRDSRDPLW
978
10
14
22
12700
|
|
POL
LWQRPLVTIKI
92
11
14
22
12701
|
|
POL
PFRKQNPDIVI
359
11
14
22
12702
|
|
POL
WWTDYWQAT
593
11
14
22
12703
|
|
POL
GYSAGERIVDI
945
11
14
22
12704
|
|
POL
VYYRDSRDPL
977
11
14
22
12705
|
|
POL
FFREDLAF
1
8
15
23
12706
|
|
POL
IYPGIKVRQL
459
10
15
23
12707
|
|
POL
PFRKQNPDI
359
9
16
25
12708
|
|
POL
RWKPKMIGGI
128
10
17
27
12709
|
|
POL
IWGKTPKFKL
574
10
17
27
12710
|
|
POL
YFSVPLDKDF
304
10
18
29
12711
|
|
POL
LWKGPAKLL
986
9
18
28
12712
|
|
POL
NMLTQIGCTL
175
10
18
28
12713
|
|
POL
IYAGIKVKQL
459
10
18
28
12714
|
|
POL
LWKGPAKLLW
986
10
18
28
12715
|
|
POL
AYFSVPLDKDF
303
11
18
28
12716
|
|
POL
AMASDFNLPPI
773
11
18
28
12717
|
|
POL
LWKGPAKL
986
8
19
30
12718
|
|
POL
DYWQATWIPE
596
11
19
30
12719
|
|
POL
DYWQATWI
596
8
20
31
12720
|
|
POL
KFKLPIQKETW
580
11
20
31
12721
|
|
POL
CWWAGIKQEF
882
10
21
33
12722
|
|
POL
LWQRPLVTI
92
9
21
33
0.0190
12723
|
|
POL
WWAGIKQEF
883
9
21
33
0.0120
12724
|
|
POL
WWAGIKQEFG
883
11
21
33
12725
|
|
POL
NFPQITLW
86
8
22
34
12726
|
|
POL
AWVPAIIKGI
726
9
22
34
12727
|
|
POL
SFPQITLW
86
8
23
36
12728
|
|
POL
WWTEYWQAT
593
10
23
36
12729
|
|
POL
WWTEYWQAT
593
11
23
36
12730
|
|
POL
PYNTPIFAI
244
9
24
38
12731
|
|
POL
YFLLKLAGRW
851
10
25
39
12732
|
|
POL
AYFLLKLAGR
850
11
25
39
12733
|
|
POL
KFRLPIQKEIW
580
11
26
41
12734
|
|
POL
QYDQILIEI
145
9
27
42
12735
|
|
POL
NWASQIYAGI
454
10
27
42
12736
|
|
POL
KWTVQPIQL
427
9
28
44
12737
|
|
POL
NWASQIYPGI
454
10
29
45
12738
|
|
POL
IWGKTPKFRL
574
10
30
47
12739
|
|
POL
WYQLEKEPI
618
9
31
48
0.0001
12740
|
|
POL
VYYDPSKDLI
509
10
31
48
0.0150
12741
|
|
POL
LWYQLEKEPI
617
10
31
48
12742
|
|
POL
YFILKLAGRW
851
10
31
48
12743
|
|
POL
AYFILKLAGR
850
11
31
48
12744
|
|
POL
EMEKEGKISKI
229
11
32
50
12745
|
|
POL
EYWQATWIPE
596
11
33
52
12746
|
|
POL
YYRDSRDPI
978
9
34
53
12747
|
|
POL
VYYRDSRDPI
977
10
34
53
12748
|
|
POL
YYRDSRDPIW
978
10
34
53
12749
|
|
POL
VYYRDSRDPI
977
11
34
53
12750
|
|
POL
YYDPSKDLI
510
9
35
55
12751
|
|
POL
IWKGPAKLL
986
9
35
55
12752
|
|
POL
IWKGPAKLLW
986
10
35
55
12753
|
|
POL
IWKGPAKL
986
8
36
56
12754
|
|
POL
EYWQATWI
596
8
37
58
12755
|
|
POL
PYNTPVFAI
244
9
37
58
0.0310
12756
|
|
POL
SWVPAIIKGI
726
9
37
58
12757
|
|
POL
KYTAFTIPSI
315
10
37
58
12758
|
|
POL
IFQSSMTKI
348
9
38
59
0.0029
12759
|
|
POL
IFQSSMTKIL
348
10
38
59
0.0002
12760
|
|
POL
VYYDPSKDL
509
9
39
61
0.0004
12761
|
|
POL
IYQEPFKNL
533
9
40
63
0.0520
12762
|
|
POL
GYSAGERIIDI
945
11
40
63
12763
|
|
POL
FFRENLAF
1
8
41
64
12764
|
|
POL
GYSAGERII
945
9
41
64
12765
|
|
POL
GFIKVRQYDQI
139
11
41
64
12766
|
|
POL
NWRAMASDF
770
11
41
64
12767
|
|
POL
EMEKEGKI
229
8
42
66
12768
|
|
POL
DFRKYTAF
312
8
42
66
12769
|
|
POL
TYQIYQEPF
530
9
42
66
0.3000
12770
|
|
POL
KWKPKMIGGI
128
10
42
66
12771
|
|
POL
DFRKYTAFTI
312
10
42
66
12772
|
|
POL
QWTYQIYQEP
528
11
42
66
12773
|
|
POL
YYDPSKDL
510
8
43
67
12774
|
|
POL
SMTKILEPF
352
9
43
67
0.0110
12775
|
|
POL
NWRAMASDF
770
9
43
67
0.0016
12776
|
|
POL
AMASDFNL
773
8
45
70
12777
|
|
POL
IWGKTPKF
574
8
48
75
12778
|
|
POL
EWIEFVNTPPL
605
10
50
78
12779
|
|
POL
GMDGPKVKQ
201
10
51
80
12780
|
|
POL
TWIPEWEF
601
8
52
81
12781
|
|
POL
YWQATWIPE
597
10
52
81
0.0660
12782
|
|
POL
SMNKELKKI
905
9
53
83
12783
|
|
POL
SMNKELKKII
905
10
53
83
12784
|
|
POL
EFVNTPPL
607
8
54
84
12785
|
|
POL
GYIEAEVI
834
8
54
84
12786
|
|
POL
SWTVNDIQKL
440
10
54
84
12787
|
|
POL
EFVNTPPLVKL
607
11
54
84
12788
|
|
POL
QWPLTIEKI
210
9
56
88
12789
|
|
POL
DFWEVQLGI
275
9
56
88
12790
|
|
POL
FWEVQLGI
276
8
57
89
12791
|
|
POL
GYSAGERI
945
8
57
89
12792
|
|
POL
LYVGSDLEI
376
9
58
91
12793
|
|
POL
KWRKLVDF
259
8
59
92
12794
|
|
POL
GWKGSPAI
341
8
59
92
12795
|
|
POL
GWKGSPAIF
341
9
59
92
12796
|
|
POL
IWQLDCTHL
812
9
59
92
0.0095
12797
|
|
POL
LWKGEGAVVI
994
10
59
92
12798
|
|
POL
KWRKLVDFRE
259
11
59
92
12799
|
|
POL
NFKRKGGI
936
8
60
94
12800
|
|
POL
GYELHPDKW
420
9
60
94
0.0001
12801
|
|
POL
QMAVFIIINF
929
9
60
94
0.0190
12802
|
|
POL
WMGYELIIPDK
418
11
6U
94
12803
|
|
POL
IYQYMDDL
369
8
61
95
12804
|
|
POL
YMDDLYVGSD
372
11
61
95
12805
|
|
POL
KMIGGIGGF
132
9
62
97
0.0011
12806
|
|
POL
KMIGGIGGPI
132
10
62
97
0.0001
12807
|
|
POL
QYNVLPQGW
334
9
63
98
0.0036
12808
|
|
POL
RYQYNVLPQG
332
11
63
98
12809
|
|
POL
PFLWMGYEL
415
9
64
100
12810
|
|
REV
RWRERQRQI
48
9
11
17
12811
|
|
REV
RWRARQRQI
48
9
35
55
12812
|
|
TAT
CYCKKCCF
28
8
11
17
12813
|
|
TAT
CFHCQVCF
34
8
11
17
12814
|
|
TAT
CFLNKGLGI
40
9
14
22
12815
|
|
VIF
RWQVLIVW
4
8
10
16
12816
|
|
VIF
RYSTQVDPGL
98
10
10)
16
12817
|
|
VIF
CFSDSAIRKAI
119
11
10
16
12818
|
|
VIF
QYLALKAL
151
8
11
17
12819
|
|
VIF
QYLALAAL
151
8
12
19
12820
|
|
VIF
RMKIRTWNSL
15
10
12
19
12821
|
|
VIF
YWGLQTGERD
71
11
12
19
12822
|
|
VIF
CFSESAIRKAI
119
11
12
19
12823
|
|
VIF
ICFSESAIRNAI
119
11
12
19
12824
|
|
VIF
VWQVDRMKI
10
9
13
20
12825
|
|
VIF
IIMIIYFDCF
113
8
15
23
12826
|
|
VIF
RMRIRTWKSL
15
10
15
23
12827
|
|
VIF
RMRIRTWNSL
15
10
15
23
12828
|
|
VIF
DWHLGQGVSI
81
10
18
28
12829
|
|
VIF
YYPDCPSESAI
115
11
20
31
12830
|
|
VIF
DWIILGIIGVSI
81
10
21
33
12831
|
|
VIF
YWGLHTGERD
71
11
22
34
12832
|
|
VIF
QYLALTALI
151
9
28
44
12833
|
|
VIF
YFDCFSESAI
116
10
28
44
12834
|
|
VIF
QYLALTAL
151
8
33
52
12835
|
|
VIF
RWQVMIVW
4
8
43
67
12836
|
|
VIF
VWQVDRMRI
10
9
48
75
12837
|
|
VIF
IIFPRIWLIISL
33
10
10
16
12838
|
|
VPR
IIFRIGCRIISRI
71
11
11
17
12839
|
|
VPR
PWLIIGLGQIII
37
10
12
19
12840
|
|
VPR
QYIYEIYGDT
44
11
14
22
12841
|
|
VPR
TWLGVEAIIRI
53
11
14
22
12842
|
|
VPR
TWAGVEAIIRI
53
11
15
23
12843
|
|
VPR
TWAGVEAI
53
8
16
25
12844
|
|
VPR
TWAGVEAII
53
9
16
25
12845
|
|
VPR
IYNTYGDTW
46
9
18
28
12846
|
|
VPR
TWEGVEAII
53
9
19
30
12847
|
|
VPR
TWEGVEAI
53
8
20
31
12848
|
|
VPR
IIFPRPWLIIGL
33
10
24
38
12849
|
|
VPR
PYNEWTLEL
14
9
30
47
0.1400
12850
|
|
VPR
PYNEWTLELL
14
10
30
47
12851
|
|
VPR
IYETYGDTW
46
9
31
48
0.0580
12852
|
|
VPR
EWTLELLEEL
17
10
40
63
12853
|
|
VPR
IIPRIGCQIISRI
71
11
44
69
12854
|
|
VPU
NYELAVGAL
5
9
01
25
12855
|
|
VPU
NYELAVGALI
5
10
01
25
12856
|
|
VPU
DYKLGVGAL
10
9
02
29
12857
|
|
VPU
DYKLGVGALI
10
10
02
29
12858
|
|
VPU
DYRLGVGAL
10
9
03
43
12859
|
|
VPU
DYRLGVGALI
10
10
03
43
12860
|
|
VPU
EMGHHAPW
89
8
11
17
12861
|
|
VPU
VPIEYRKI
37
8
12
19
12862
|
|
VPU
EYRKILRQRKI
41
11
13
21
12863
|
|
TABLE XIXa
|
|
|
HIV DR Super Motif Peptides
|
Core
|
Core
Sequence
Exemplary
Exemplary
|
Core
Sequence
Conservancy
Sequence
Sequence
|
Protein
Sequence
Frequency
(%)
Exemplary Sequence
Position
Frequency
Conservancy (%)
SEQ ID NO.
|
|
ENV
VSTQLLLNG
61
95
KPVVSTQLLLNGSLA
299
29
45
12864
|
|
ENV
VVSTQLLLN
60
94
IKPVVSTQLLLNGSL
298
29
45
12865
|
|
ENV
LTVWGIKQL
59
92
LLQLTVWGIKQLQAR
651
26
41
12866
|
|
ENV
LLSGIVQQQ
58
91
ARQLLSGIVQQQSNL
627
22
34
12867
|
|
ENV
WATHACVPT
56
88
HNVWATHACVPTDPN
79
44
69
12868
|
|
ENV
LGAAGSTMG
55
86
LGFLGAAGSTMGAAS
605
36
56
12869
|
|
ENV
VRQGYSPLS
55
86
VNRVRQGYSPLSFQT
800
36
57
12870
|
|
ENV
LLLNGSLAE
54
84
STQLLLNGSLAEEEV
303
16
25
12871
|
|
ENV
VKLTPLCVT
53
83
KPCVKLTPLCVTLNC
130
29
45
12872
|
|
ENV
LRAIEAQQH
51
80
NNLLRAIEAQQIILLQ
639
18
28
12873
|
|
ENV
VSTVQCTHG
51
80
CKNVSTVQCTHGIKP
285
14
22
12874
|
|
ENV
LGIWGCSGK
50
78
QQLLGIWGCSGKLIC
676
46
72
12875
|
|
ENV
LWDQSLKPC
50
78
IISLWDQSLKPCVKL
121
35
55
12876
|
|
ENV
LGFLGAAGS
49
77
AVFLGFLGAAGSTMG
602
19
30
12877
|
|
ENV
VWATHACVP
49
77
VHNVWATHACVPTDP
78
34
53
12878
|
|
ENV
WGIKQLQAR
49
77
LTVWGIKQLQARVLA
654
39
61
12879
|
|
ENV
LWYIKIFIM
43
67
TNWLWYIKIFIMIVG
771
11
17
12880
|
|
ENV
FCASDAKAY
42
66
TTLFCASDAKAYDTE
61
18
28
12881
|
|
ENV
IVGGLIGLR
42
66
FIMIVGGLIGLRIVF
780
22
34
12882
|
|
ENV
IFIMIVGGL
41
64
YIKIFIMIVGGLIGL
776
30
47
12883
|
|
ENV
VYYGVPVWK
41
64
WVTVYYGVPVWKEAT
46
22
34
12884
|
|
ENV
IKQLQARVL
40
63
VWGIKQLQARVLAVE
656
31
49
12885
|
|
ENV
IKIFIMIVG
39
61
LWYIKIWIMIVGGLI
774
31
48
12886
|
|
ENV
MGAASITLT
39
61
GSTMGAASITLTVQA
613
28
44
12887
|
|
ENV
YIKIFIMIV
39
61
WLWYIKIFIMIVGGL
773
38
59
12888
|
|
ENV
ITGLLLTRD
37
58
SSNITGLLLTRDGGK
516
06
9
12889
|
|
ENV
IPIHYCAPA
36
56
FEPIPIHYCAPAGFA
255
21
33
12890
|
|
ENV
MIVGGLIGL
36
56
IFIMIVGGLIGLRIV
779
22
34
12891
|
|
ENV
VQARQLLSG
36
56
TLTVQARQLLSGIVQ
622
35
55
12892
|
|
ENV
FEPIPIHYC
35
55
KVSFEPIPIHYCAPA
252
17
27
12893
|
|
ENV
LRSLCLFSY
35
55
WDDLRSLCLFSYHRL
854
28
44
12894
|
|
ENV
MWKNNMVEQ
35
55
NFNMWKNNMVEQMHE
105
11
17
12895
|
|
ENV
VHNVWATHA
35
55
DTEVHNVWATIIACVP
75
17
27
12896
|
|
ENV
WKNNMVEQM
35
55
FNMWKNNMVEQMHED
106
20
31
12897
|
|
ENV
YYGVPVWKE
35
55
VTVYYGVPVWKEATT
47
22
34
12898
|
|
ENV
LLQLTVWGI
34
53
QQHLLQLTVWGIKQL
648
34
53
12899
|
|
ENV
IEPLGVAPT
33
52
VVKIEPLGVAPTKAK
566
12
19
12900
|
|
ENV
IKPVVSTQL
33
52
THGIKPVVSTQLLLN
295
32
50
12901
|
|
ENV
LQARVLAVE
33
52
IKQLQARVLAVERYL
659
32
50
12902
|
|
ENV
WDDLRSLCL
33
52
ALAWDDLRSLCLFSY
851
18
28
12903
|
|
ENV
IINIHTPHR
01
50
SRPIINIHTPHREKR
581
01
2
12904
|
|
ENV
INIHTPHRE
01
50
RPTINIHTPHREKRA
582
01
2
12905
|
|
ENV
ITQACPKVS
32
50
TSVITQACPKVSFEP
242
08
13
12906
|
|
ENV
IVQQQSNLL
32
50
LSOIVQQQSNLLRAI
631
26
41
12907
|
|
ENV
LGNNSTNST
01
50
NKTLGNNSTNSTLGN
151
01
2
12908
|
|
ENV
VISTRTHRE
01
50
ARPVISTRTHREKRA
580
01
2
12909
|
|
ENV
WRWGTLFLG
01
50
QNLWRWGTLFLGMLM
12
01
2
12910
|
|
ENV
WRWGTMLLG
01
50
QHLWRWGTMLLGMLM
12
03
5
12911
|
|
ENV
FAVLSIVNR
31
48
RIVFAVLSIVNRVRQ
791
14
22
12912
|
|
ENV
LLNGSLAEE
31
48
TQLLLNGSLAEEEVV
304
14
22
12913
|
|
ENV
LTPLCVTLN
29
45
CVKLTPLCVTLNCTD
132
11
17
12914
|
|
ENV
LYKYKVVKI
29
45
RSELYKYKVVKIEPL
558
23
36
12915
|
|
ENV
VPWNSSWSN
29
45
TTNVPWNSSWSNKSL
691
03
5
12916
|
|
ENV
YRLINCNTS
28
44
YKEYRLINCNTSAIT
232
01
8
12917
|
|
ENV
IHYCAPAGF
27
42
PIPIHYCAPAGFAIL
258
26
41
12918
|
|
ENV
LKDQQLLGI
27
42
ERYLKDQQLLGIWGC
670
25
39
12919
|
|
ENV
YKYKVVKIE
27
42
SELYKYKVVKIEPLG
559
24
38
12920
|
|
ENV
IRPVVSTQL
26
41
THGIRPVVSTQLLLN
295
26
41
12921
|
|
ENV
LDKWASLWN
26
41
LLALDKWASLWNWFD
755
08
13
12922
|
|
ENV
LRIVFAVLS
26
41
LIGLRIVFAVLSIVN
787
10
16
12923
|
|
ENV
LNGSLAEEE
25
39
QLLLNGSLAEEEVVI
305
13
20
12924
|
|
ENV
YKVVKIEPL
25
39
LYKYKVVKIEPLGVA
561
23
36
12925
|
|
ENV
LKGLRLGWE
11
37
RSSLKGLRLGWEGLK
885
04
7
12926
|
|
ENV
FSYHRLRDL
23
36
LCLFSYIIRLRDLLLI
860
08
13
12927
|
|
ENV
INCTRPNNN
23
36
SVEINCTRPNNNTRK
340
05
8
12928
|
|
ENV
VVKIEPLGV
23
36
KYKVVKIEPLGVAPT
563
23
36
12929
|
|
ENV
WKEATTTLF
23
36
VPVWKEATTTLFCAS
53
22
34
12930
|
|
ENV
IGLRIVFAV
22
34
GGLIGLRIVFAVLSI
785
12
19
12931
|
|
ENV
FFYCNISGL
21
33
GGEFFYCNTSGLFNS
411
07
11
12932
|
|
ENV
FGLGALFLG
01
33
RAAFGLGALFLGFLG
594
01
2
12933
|
|
ENV
FYCNTSGLF
21
33
GEFFYCNTSGLFNST
442
07
11
12934
|
|
ENV
LIGLRIVFA
21
33
VGGLIGLRIVFAVLS
784
17
27
12935
|
|
ENV
VGLGAVFLG
01
33
KRAVGLGAVFLGFLG
593
06
9
12936
|
|
ENV
VGLGMLFLG
01
33
KRAVGLGMLFLGVLS
594
01
2
12937
|
|
ENV
ICTPAVPWN
20
31
GKLICTIAVPWNSSW
686
09
14
12938
|
|
ENV
ICTTNVPWN
20
31
GKLICTTNVPWNSSW
686
08
13
12939
|
|
ENV
LGVAPTKAK
19
30
IEPLCVAPTKAKRRV
569
15
23
12940
|
|
ENV
LICTTAVPW
19
30
SGKLICTTAVPWNSS
685
09
14
12941
|
|
ENV
LRDQQLLGI
19
30
ERYLRDQQLLGIWGC
670
17
27
12942
|
|
ENV
VFLGFLGAA
19
30
LGAVFLGFLGAAGST
600
09
14
12943
|
|
ENV
FSYHRLRDF
18
28
LCLFSYHRLRDFILI
860
08
13
12944
|
|
ENV
IPIHYCTPA
18
28
FEPIPIHYCTPAGFA
255
10
16
12945
|
|
ENV
IVFAVLSIV
18
28
GLRIVFAVLSIVNRV
789
16
25
12946
|
|
ENV
VFAVLSIVN
18
28
LRIVFAVLSIVNRVR
790
16
25
12947
|
|
ENV
VPWNASWSN
18
28
TTAVPWNASWSNKSL
691
06
9
12948
|
|
ENV
IGLRIIFAV
17
27
GGLIGLRIIPAYLST
785
11
17
12949
|
|
ENV
IRQAHCNIS
17
27
IODIRQAHCNISRAK
378
02
3
12950
|
|
ENV
VAPTKAKRR
17
27
PLGVAPTKAKRRVVQ
571
10
16
12951
|
|
ENV
FNGTGPCKN
16
25
DKKPNGTGPCKNVST
276
05
8
12952
|
|
ENV
IGPGQTFYA
01
25
SVRIGPGQTFYATGD
355
03
5
12953
|
|
ENV
IGSGQAFYV
01
25
RYSIGSGQAFYVTGK
358
01
2
12954
|
|
ENV
IRYLNLVNQ
01
25
QTAIRYLNLVNQTEN
400
01
2
12955
|
|
ENV
LIGLRIIFA
16
25
VGGLIGLRIIFAVLS
784
12
19
12956
|
|
ENV
LLQYWSQEL
16
25
WWNLLQYWSQELKNS
903
09
14
12957
|
|
ENV
LRNLCLFSY
16
25
WDDLRNLCLFSYHRL
854
11
17
12958
|
|
ENV
LVSGFLALA
16
25
SIRLVSGFLALAWDD
842
09
14
12959
|
|
ENV
VSGFLALAW
16
25
IRLVSGFLALAWDDL
843
09
14
12960
|
|
ENV
EDPIPIHYC
15
23
KVTFDPIPIHYCTPA
252
03
5
12961
|
|
ENV
IIFAVLSIV
15
23
GLRIIFAVLSIVNRV
789
13
20
12962
|
|
ENV
LINCNTSAI
15
23
EYRLINCNTSAITQA
234
04
9
12963
|
|
ENV
LLNATAIAV
15
23
AVSLLNATAIAVAEG
918
10
16
12964
|
|
ENV
LRIIFAVLS
15
23
LIGLRIIFAVLSIVN
787
11
17
12965
|
|
ENV
VITQACPKV
15
23
NTSVITQACPKVSFE
241
08
13
12966
|
|
ENV
YWWNLLQYW
15
23
VLKYWWNLLQYWSQE
899
07
11
12967
|
|
ENV
FAILKCNDK
14
22
PAGFAILKCNDKKFN
266
09
14
12968
|
|
ENV
IFAVLSIVN
14
22
LRIIFAVLSIVNRVR
790
13
20
12969
|
|
ENV
INCNTSAIT
14
22
YRLINCNTSAITQAC
235
14
22
12970
|
|
ENV
LNATAIAVA
14
22
VSLLNATAIAVAEGT
919
10
16
12971
|
|
ENV
WNSSWSNKS
14
22
NVPWNSSWSNKSLDE
693
03
5
12972
|
|
ENV
WNASWSNKS
13
21
NVPWNASWSNKSYED
693
02
3
12973
|
|
ENV
ICTTTVPWN
13
20
GKLTCTTTVPWNASW
686
06
9
12974
|
|
ENV
LLKLTVWGI
13
20
QQHLLKLTVWGIKQL
648
13
20
12975
|
|
ENV
LYKYKVVEI
13
20
RSELYKYKVVEIKPL
558
05
8
12976
|
|
ENV
MFLGFLGAA
13
20
LGAMFLGFLGAAGST
600
07
11
12977
|
|
ENV
MHSFNCGGE
13
20
EIVMHSFNCGGEFFY
430
13
20
12978
|
|
ENV
YWSQELKNS
13
20
LLQYWSQELKNSAVS
906
10
16
12979
|
|
ENV
IGAVFLGFL
12
19
AVCIGAVFLGFLGAA
595
09
14
12980
|
|
ENV
LIAARTVEL
12
19
DFILIAARTVELLGH
870
04
6
12981
|
|
ENV
LICTTTVPW
12
19
SGKLICTTTVPWNAS
685
06
9
12982
|
|
ENV
LLNGSLAEG
12
19
TQLLLNGSLAEGEII
304
03
5
12983
|
|
ENV
YWGQELKNS
12
19
LVWYWGQELKNSAIS
906
02
3
12984
|
|
ENV
IAARTVELL
11
17
FILIAARTVELLGHS
871
03
5
12985
|
|
ENV
LFLGFLGAA
11
17
IGALFLGFLGAAGST
600
06
9
12986
|
|
ENV
LKNSAVSLL
11
17
SQELKNSAVSLLNAT
911
08
13
12987
|
|
ENV
VGTGAVFLG
11
17
KRAVGIGAVFLGFLG
593
11
17
12988
|
|
ENV
VSLLNATAI
11
17
NSAVSLLNATAIAVA
916
09
14
12989
|
|
ENV
YATGDIIGD
11
17
QTPYATGDIIGDIRQ
365
04
6
12990
|
|
ENV
IAIAVAEGT
10
16
LDIIAIAVAEGTDRI
922
02
3
12991
|
|
ENV
IHYCTPAGF
10
16
PIPIHYCTPAGFAIL
258
08
13
12992
|
|
ENV
ILGLVTICS
10
16
GTLILGLVIICSASN
19
03
5
12993
|
|
ENV
IWNNMTWME
10
16
VDETWNNMTWMEWER
714
01
2
12994
|
|
ENV
LGLVIICSA
10
16
TLILGLVIICSASNN
20
04
6
12995
|
|
ENV
LRDFILIAA
10
16
YHRLRDFILIAARTV
865
06
9
12996
|
|
ENV
LTPLCVTLD
10
16
CVKLTPLCVTLDCHN
132
03
5
12997
|
|
ENV
MLQLTVWGI
10
16
QQHMLQLTVWGIKQL
648
08
13
12998
|
|
ENV
VEINCTRPN
10
16
NESVEINCTRPNWNT
338
02
3
12999
|
|
ENV
VRQLLSGIV
10
16
TVQVRQLLSGIVQQQ
624
08
13
13000
|
|
ENV
LILGLVIIC
09
15
WGTLILGLVIICSAS
18
07
11
13001
|
|
GAG
VGGHQAAMQ
60
94
LNTVGGHQAAMQMLK
209
47
73
13002
|
|
GAG
LLVQNANPD
59
92
TETLLVQNANPDCKT
342
26
41
13003
|
|
GAG
VQNANPDCK
59
92
TLLVQNANPDCKTIL
344
44
69
13004
|
|
GAG
LGLNKIVRM
58
91
WIILGLNKIVRMYSP
289
55
86
13005
|
|
GAG
LSEGATPQD
58
91
FSALSEGATPQDLNT
193
29
45
13006
|
|
GAG
WIILGLNKI
57
89
YKRWIILGLNKIYRM
286
54
84
13007
|
|
GAG
LEEMMTACQ
56
88
GATLEEMMTACQGVG
364
27
42
13008
|
|
GAG
YKRWIILGL
55
86
GEIYKRWIILGLNKI
283
37
58
13009
|
|
GAG
IYKRWIILG
54
84
VGEIYKRWIILGLNK
282
37
58
13010
|
|
GAG
VSQNYPIVQ
48
83
SSQVSQNYPIVQNLQ
145
09
19
13011
|
|
GAG
WEKIRLRPG
50
78
LDKWEKIRLRPGGKK
13
16
25
13012
|
|
GAG
IAGTTSTLQ
46
72
GSDIAGTTSTLQEQI
254
45
70
13013
|
|
GAG
WASRELERF
46
72
HLVWASRELERFALN
34
17
27
13014
|
|
GAG
IPMFSALSE
45
70
PEVIFMFSALSEGAT
187
44
69
13015
|
|
GAG
MFSALSEGA
45
70
VIPMFSALSEGATPQ
189
43
67
13016
|
|
GAG
VIFMFSALS
45
70
SPEVIFMFSALSEGA
186
40
63
13017
|
|
GAG
MYSPVSILD
41
64
IVRMYSPVSILDIRQ
297
23
36
13018
|
|
GAG
IVRMYSPVS
40
63
LNKIVRMYSPVSILD
294
39
61
13019
|
|
GAG
VRMYSPVSI
40
63
NKIVRMYSPVSILDI
295
38
59
13020
|
|
GAG
YSPVSILDI
40
63
VRMYSPVSILDIRQG
298
23
36
13021
|
|
GAG
MTETLLVQN
38
59
KNWMTETLLVQNANP
338
34
53
13022
|
|
GAG
WMTETLLVQ
37
58
VKNWMTETLLVQNAN
337
34
53
13023
|
|
GAG
ISPRTLNAW
36
56
HQAISPRTLNAWVKV
165
27
42
13024
|
|
GAG
VKNWMTETL
36
56
TQEVKNWMTETLLVQ
334
14
22
13025
|
|
GAG
IKCFNCGKE
34
53
QKRIKCFNCGKEGHL
418
05
8
13026
|
|
GAG
IPVGEIYKR
34
53
NPPIPVGEIYKRWII
277
32
51
13027
|
|
GAG
YTAVFMQRG
02
50
KGGYTAVIMQRGQNP
399
02
3
13028
|
|
GAG
VATLYCVHQ
30
47
YNTVATLYCVHQRIE
81
07
11
13029
|
|
GAG
WDRLHPVHA
29
45
AAEWDRLIIPVHAGPI
230
22
34
13030
|
|
GAG
FLQSRPEPT
28
44
PGNFLQSRPEPTAPP
483
27
43
13031
|
|
GAG
FKTLRAEQA
27
42
DRFFKTLRAEQATQE
322
16
25
13032
|
|
GAG
MVHQAISPR
27
42
QGQMVHQAISPRTLN
160
26
41
13033
|
|
GAG
VHQAISPRT
27
42
GQMVHQAISPRTLNA
161
27
42
13034
|
|
GAG
YKTLRAEQA
27
42
DRFYKTLRAEQASQE
322
12
19
13035
|
|
GAG
VSILDTRQG
25
39
YSPVSILDIRQGPKE
301
24
38
13036
|
|
GAG
LAEAMSQVT
23
37
ARVLAEAMSQVTNSA
384
08
13
13037
|
|
GAG
LGKIWPSHK
23
36
ANFLGKIWPSHKGRP
467
22
34
13038
|
|
GAG
VKCFNCGKE
23
36
RKTVKCFNCGKEGHI
420
07
11
13039
|
|
GAG
YNTVATLYC
23
36
RSLYNTVATLYCVHQ
78
11
17
13040
|
|
GAG
LHPVHAGPI
22
34
WDRLHPVHAGPIAPG
233
15
23
13041
|
|
GAG
LYNTVATLY
22
34
LRSLYNTVATLVCVH
77
13
20
13042
|
|
GAG
MTDTLLVQN
22
34
KNWMTDTLLVQNANP
338
16
25
13043
|
|
GAG
WMTDTLLVQ
22
34
VKNWMTDTLLVQNAN
337
16
25
13044
|
|
GAG
IEVKDTKEA
21
33
HQRIEVKDTKEALDK
91
07
11
13045
|
|
GAG
LQGQMVHQA
21
33
VQNLQGQMVHQAISP
156
15
23
13046
|
|
GAG
MTNNPPIPV
20
31
IGWMTNNPPIPVGEI
268
16
25
13047
|
|
GAG
WMTNNPPIP
20
31
QIGWMTNNPPIPVGE
267
16
25
13048
|
|
GAG
IAPGQMREP
19
30
AGPIAPGQMREPRGS
241
19
30
13049
|
|
GAG
VHAGPIAPG
19
30
LHPVHAGPIAPGQMR
236
14
22
13050
|
|
GAG
LGPGATLEE
18
28
LRALGPGATLEEMMT
358
09
14
13051
|
|
GAG
VHAGPIPPG
18
28
VHPVHAGPIPPGQMR
236
10
16
13052
|
|
GAG
IPPGQMREP
17
27
AGPIPPGQMREPRGS
241
16
25
13053
|
|
GAG
LSPRTLNAW
17
27
HQALSPRTLNAWVKV
165
10
16
13054
|
|
GAG
YRLKHLVWA
17
27
KKKYRLKHLVWASRE
27
13
20
13055
|
|
GAG
LGPAATLEE
16
25
LKALGPAATLEEMMI
358
16
25
13056
|
|
GAG
LKALGPAAT
16
25
KTILKALGPAATLEE
355
16
25
13057
|
|
GAG
LKDKEPPLA
01
25
QEQLKDKEPPLASLR
532
01
2
13058
|
|
GAG
LSGGKLDAW
16
25
ASVLSGGKLDAWEKI
5
14
22
13059
|
|
GAG
MISNPPIPV
16
25
IGWMTSNPPIPVGEI
268
06
9
13060
|
|
GAG
VKNWMTDTL
16
25
TQDVKNWMTDTLLVQ
334
11
17
13061
|
|
GAG
VSILDIKQG
16
25
YSPVSILD1KQGPKE
301
16
25
13062
|
|
GAG
WMTSNPPIP
16
25
QIGWMTSNPPIPVGE
267
06
10
13063
|
|
GAG
FNTVATLYC
13
23
KSLFNTVATLYCVIIQ
78
07
11
13064
|
|
GAG
IPMFTALSE
15
23
PEVIPMFTALSEGAT
187
13
20
13065
|
|
GAG
LASLKSLFG
15
23
LYPLASLKSLFGNDP
544
06
11
13066
|
|
GAG
LERFAVNPG
15
23
SRELERFAVNPGLLE
39
14
22
13067
|
|
GAG
LFNTVATLY
15
23
LRSLFNTVATLYCVH
77
07
11
13068
|
|
GAG
MFTALSEGA
15
23
VIPMFTALSEGATPQ
189
14
22
13069
|
|
GAG
WDRVHPVHA
15
23
AAEWDRVKPVIIAGPI
230
12
19
13070
|
|
GAG
IVRMYSPTS
14
22
LNKIVRMYSPTSILD
294
13
20
13071
|
|
GAG
LERFALNPG
14
22
SRELERFALNPGLLE
39
14
22
13072
|
|
GAG
LQEQIAWMT
14
22
TSTLQEQIAWMTGNP
261
05
8
13073
|
|
GAG
VHPVHAGPI
14
22
WDRVHPVIIAGPIPPG
233
11
17
13074
|
|
GAG
VIPMFTALS
14
22
SPEVIPMFTALSEGA
186
13
20
13075
|
|
GAG
VRMYSPTSI
14
22
NKIVRMYSPTSILDI
295
23
20
13076
|
|
GAG
LGKIWPSNK
13
20
ANFLGKIWPSNKGRP
467
13
20
13077
|
|
GAG
LTSLKSLFG
13
20
LYPLTSLKSLFGNDP
544
04
7
13078
|
|
GAG
MYSPTSILD
13
20
IVRMYSPTSILDIRQ
297
12
19
13079
|
|
GAG
YKLKHIVWA
13
20
KKKYKLKHIVWASRE
27
08
13
13080
|
|
GAG
YSPTSILDI
13
20
VRMYSPTSILDIRQG
298
12
19
13081
|
|
GAG
LTSLRSLFG
12
19
LYPLTSLRSLFGNDP
544
04
7
13082
|
|
GAG
MMLNIVGGH
12
19
DLNMMLNIVGGHQAA
204
12
19
13083
|
|
GAG
IDVKDTKEA
11
17
HQRIDVKDTKEALDK
91
03
5
13084
|
|
GAG
IGWMTSNPP
11
17
QEQIGWMTSNPPIPV
265
09
14
13085
|
|
GAG
IPVGDIYKR
11
17
NPPIPVGDIYKRWII
277
08
13
13086
|
|
GAG
LYPLASLKS
09
17
DKELYPLASLKSLFG
541
06
10
13087
|
|
GAG
VHQALSPRT
11
17
GQMVHQALSPRTLNA
161
07
11
13088
|
|
GAG
VNPGLLETS
11
17
RPAVNPGLLETSEGC
45
11
17
13089
|
|
GAG
YPLASLKSL
08
17
KELYPLASLKSLFGN
542
06
9
13090
|
|
GAG
FLQNRPEPT
10
16
PGNFLQNRPEPTAPP
483
10
16
13091
|
|
GAG
IMMQKSNFK
10
16
AAAIMMQKSNFKGPR
405
01
25
13092
|
|
GAG
LAEAMSQVQ
10
16
ARVLAEAMSQVQQSN
384
02
3
13093
|
|
GAG
LGKIWPSSK
10
16
ANFLGKIWPSSKGRP
467
10
16
13094
|
|
GAG
LNPGLLETA
10
16
RFALNPGLLETAEGC
45
08
13
13095
|
|
GAG
YPLASLRSL
07
15
KELYPLASLRSLFGN
542
04
6
13096
|
|
NEF
WQNYTPGPG
52
83
FPDWQNYTPGPGIRY
200
15
23
13097
|
|
NEF
VRPQVPLRP
48
75
GFPVRPQVPLRPMTY
93
36
56
13098
|
|
NEF
VPLRPMTYK
46
73
RPQVPLRPMTYKGAF
98
07
11
13099
|
|
NEF
LTFGWCFKL
39
61
RYPLTFGWCFKLVPV
216
15
24
13100
|
|
NEF
ILDLWVYHT
34
53
RQEILDLWVYHTQGY
182
12
19
13101
|
|
NEF
WCFKLVPVD
26
41
TFGWCFKLVPVDPRE
222
07
11
13102
|
|
NEF
LWVYHTQGY
21
33
ILDLWVYHTQGYFPD
186
21
33
13103
|
|
NEF
WSKSSIVGW
20
31
GGKWSKSSIVGWPAI
2
05
8
13104
|
|
NEF
ILDLWVYNT
19
30
RQDILDLWVYNTQGY
182
05
8
13105
|
|
NEF
LLHPMSQHG
17
27
NNCLLHPMSQHGMDD
254
06
9
13106
|
|
NEF
LLHPICQHG
16
25
NNSLLHPICQHGMED
254
04
6
13107
|
|
NEF
IRYPLTFGW
13
20
GPGIRYPLTFGWCFK
210
06
9
13108
|
|
NEF
ITSSNTAAT
13
20
HGAITSSNTAATNAD
61
10
16
13109
|
|
NEF
LEKHGAITS
13
20
SRDLEKHGAITSSNT
50
13
20
13110
|
|
NEF
LWVYHTQGF
13
20
ILDLWVYHTQGFFPD
186
13
20
13111
|
|
NEF
MTYKGAFDL
12
19
LRPMTYKGAFDLSFF
103
06
9
13112
|
|
NEF
LVPVDPREV
11
17
CFKLVPVDPREVEEA
226
08
13
13113
|
|
NEF
VGWPAIRER
10
17
SSIVGWPAIRERMRR
8
03
5
13114
|
|
NEF
WCFKLVPVE
11
17
TFGWCFKLVPVEPEK
222
04
6
13115
|
|
NEF
FDSRLAFHH
10
16
EWRFDSRLAFHHVAR
307
02
3
13116
|
|
NEF
FKLVPVDPR
10
16
GWCFKLVPVDPREVE
224
10
16
13117
|
|
NEF
VPLRPMTFK
10
16
RPQVPLRPMTFKOAF
98
04
6
13118
|
|
POL
LLDTGADDT
63
98
KEALLDTGADDTVLE
107
37
58
13119
|
|
POL
WMGYELHPD
63
98
PFLWMGYELHPDKWT
415
60
94
13120
|
|
POL
YQYNVLPQG
63
98
GTRYQYNVLPQGWKG
330
52
81
13121
|
|
POL
FRKYTAFTI
61
97
DKDFRKYTAFTIPSI
310
10
16
13122
|
|
POL
WTVNDIQKL
62
97
KDSWTVNDIQKLVGK
438
43
67
13123
|
|
POL
LDCTHLEGK
61
95
IWQLDCTHLEGKIIL
812
29
45
13124
|
|
POL
LDVGDAYFS
61
95
VTVLDVGDAYFSVPL
295
50
78
13125
|
|
POL
MDDLYVGSD
6I
95
YQVMDDLYVGSDLEI
370
57
89
13126
|
|
POL
VIFAETGQE
61
95
EAEVIFAETCQETAY
837
57
90
13127
|
|
POL
WKGEGAVVI
61
95
KLLWKGEGAVVIQDN
992
53
83
13128
|
|
POL
WQLDCTHLE
61
95
PGIWQLDCTHLEGKI
810
32
50
13129
|
|
POL
VDFRELNKR
60
94
RKLVDFRELNKRTQD
261
57
89
13130
|
|
POL
WKPKMIGGI
60
94
PGKWKPKMIGGIGGF
126
39
61
13131
|
|
POL
IWQLDCTHL
59
92
SPGIWQLDCTHLEGK
809
56
88
13132
|
|
POL
VAVHVASGY
59
92
IILVAVHVASGYIEA
824
26
41
13133
|
|
POL
WKGSPAIFQ
59
92
PQGWKGSPAIFQSSM
339
42
66
13134
|
|
POL
IGGYSAGER
58
91
KGGIGGYSAGERIID
940
37
59
13135
|
|
POL
YALGIIQAQ
58
91
DSQYALGIIQAQPDK
690
39
61
13136
|
|
POL
FWEVQLGIP
57
89
TQDFWEVQLGIPHPA
273
52
81
13137
|
|
POL
IKKKDSTKW
57
89
VFAIKKKDSTKWRKL
249
36
56
13138
|
|
POL
LGIIQAQPD
57
89
QYALGIIQAQPDKSE
692
39
61
13139
|
|
POL
LGIPHPAGL
56
89
EVQLGIPHPAGLKKK
278
51
80
13140
|
|
POL
VNTPPLVKL
57
89
WEFVNTPPLVKLWYQ
606
50
79
13141
|
|
POL
VTVLDVGDA
57
89
KKSVTVLDVGDAYFS
292
49
77
13142
|
|
POL
FPISPIETV
56
88
TLNFPISPIETVPVK
183
52
83
13143
|
|
POL
ISPIETVPV
56
88
NFPISPIETVPVKLK
185
52
81
13144
|
|
POL
FVNTPPLVK
54
86
EWEFVNTPPLVKLWY
605
50
78
13145
|
|
POL
LNFPISPIE
55
86
GCTLNFPISPIHTVP
181
53
83
13146
|
|
POL
WEFVNTPPL
54
86
IPEWEFVNTPPLVKL
603
49
77
13147
|
|
POL
IQNPRVYYR
52
84
ITKIQNFRVYYRDSR
969
32
51
13148
|
|
POL
LVGPTPVNI
54
84
GTVLVGPTPVNIIGR
160
51
80
13149
|
|
POL
VQLGIPHPA
54
84
FWEVQLGIPHPAGLK
276
53
83
13150
|
|
POL
WQATWIPEW
54
84
TEYWQATWIPEWEFV
595
19
30
13151
|
|
POL
IETVPVKLK
53
83
ISPIETVPVKLKPGM
188
51
80
13152
|
|
POL
IGTYLVGPT
53
83
KKAIGTVLVGPTPVN
156
22
34
13153
|
|
POL
LVAVHVASG
53
83
KIILVAVHVASGYIE
823
26
41
13154
|
|
POL
VLVGPTPVN
53
83
IGTVLVGPTPVNIIG
159
45
70
13155
|
|
POL
YIEAEVIPA
53
83
ASGYIEAEVIPAETG
832
52
81
13156
|
|
POL
YVGSDLEIG
53
83
DDLYVGSDLEIGQHR
374
52
81
13157
|
|
POL
MDGPKVKQW
52
81
KPGMDGPKVKQWPLT
199
47
73
13158
|
|
POL
VASGYIEAE
52
81
AVHVASGYIEAEVIP
828
52
81
13159
|
|
POL
VOPTPVNII
52
81
TVLVUPTPVNIIGRN
161
51
80
13160
|
|
POL
VKQWPLTEE
52
81
GPKVKQWPLTEEKIK
205
45
70
13161
|
|
POL
VYYRDSRDP
52
81
NFRVYYRDSRDPIWK
974
29
45
13162
|
|
POL
WGFTTPDKK
52
81
LLRWGFTTPDKKHQK
398
23
36
13163
|
|
POL
VIYQYMDDL
51
80
PEIVIYQYMDDLYVG
365
23
36
13164
|
|
POL
LKKKKSVTV
49
78
PAGLKKKKSVTVLDV
286
46
72
13165
|
|
POL
VPRRKAKII
50
78
IKVVPRRKAKIIRDY
1010
41
64
13166
|
|
POL
FPQITLWQR
49
77
SFSFPQITLWQRPLV
84
09
14
13167
|
|
POL
VIWGKTPKF
47
73
ESIVIWGKTPKFRLP
570
23
37
13168
|
|
POL
YVDGAANRE
46
72
ETFYVDGAANRETKL
630
24
38
13169
|
|
POL
FKNLKTGKY
45
70
QEPFKNLKTGKYAKM
535
15
23
13170
|
|
POL
IQTKELQKQ
45
70
ATDIQTKELQKQITK
957
24
38
13171
|
|
POL
YGKQMAGDD
45
70
IRDYGKQMAGDDCVA
1021
41
64
13172
|
|
POL
WRAMASDFN
43
67
IISNWRAMASDFNLPP
768
31
48
13173
|
|
POL
ISKIGPENP
42
66
EGKISKIGPENPYNT
233
40
63
13174
|
|
POL
LTQIGCTLN
41
64
RNLLTQIGCTLNPPI
174
21
33
13175
|
|
POL
IIQAQPDKS
40
63
ALGIIQAQPDKSESE
694
38
59
13176
|
|
POL
LPEKDSWTV
40
63
PIVLPEKDSWTVNDI
432
13
20
13177
|
|
POL
FQSSMTKIL
38
59
PAIFQSSMTKILEPF
346
32
50
13178
|
|
POL
FTIPSINNE
38
59
YTAFTIPSINNETPG
316
36
56
13179
|
|
POL
IFQSSMTKI
38
59
SPAIFQSSMTKILEP
345
33
52
13180
|
|
POL
IIEQLIKKE
37
58
VSQIIEQLIKKEKVY
710
19
30
13181
|
|
POL
LSWVPAHKG
37
58
KVYLSWVPAHKGIGG
722
23
37
13182
|
|
POL
YLSWVPAHK
37
58
EKVYLSWVPAHKG1G
721
15
24
13183
|
|
POL
YTAFTIPSI
37
58
FRKYTAFTIPSINNE
313
37
59
13184
|
|
POL
IIATDIQTK
35
55
IIDIIATDIQTKELQ
952
22
34
13185
|
|
POL
IWKGPAKLL
35
55
RDPIWKGPAKLLWKG
983
34
53
13186
|
|
POL
LQKQITKIQ
35
55
TKELQKQITKIQNFR
962
29
46
13187
|
|
POL
LKEALLDTG
34
53
GGQLKEALLDTGADD
103
31
48
13188
|
|
POL
VYLSWVPAH
33
52
KEKVYLSWVPAHKGI
720
15
23
13189
|
|
POL
FILKLAGRW
32
50
TAYFILKLAGRWPVK
849
27
42
13190
|
|
POL
LEGKIILVA
31
48
CTHLEGKIILVAVHV
817
30
47
13191
|
|
POL
YFILKLAGR
31
48
ETAYFILKLAGRWPV
848
30
47
13192
|
|
POL
IILVAVHVA
30
47
EGKIILVAVHVASGY
821
30
47
13193
|
|
POL
IWGKTPKFR
30
47
SIVIWGKTPKFRLPI
571
22
34
13194
|
|
POL
LAGRWPVKV
30
47
ILKLAGRWPVKVIHT
853
19
30
13195
|
|
POL
VVAKEIVAS
30
47
LPPVVAKEIVASCDK
780
21
33
13196
|
|
POL
IDIIATDIQ
29
45
ERIIDIIATDIQTKE
950
22
34
13197
|
|
POL
IIDITATDI
29
45
GERIIDIIATDTQTK
949
23
36
13198
|
|
POL
IIGRNMLTQ
29
45
PVNIIGRNMLTQLGC
168
11
17
13199
|
|
POL
IKVKQLCKL
29
45
YAGIKVKQLCKLLRG
460
18
28
13200
|
|
POL
VDKLVSSGI
29
45
NEQVDKLVSSGIRKV
737
26
41
13201
|
|
POL
IVGAETFYV
28
44
KEPIVGAETFYVDGA
623
16
25
13202
|
|
POL
LPPVVAKEI
28
44
DFNLPPVVAKEIVAS
777
26
41
13203
|
|
POL
WTVQPIQLP
28
44
PDKWTVQPIQLPEKD
425
13
20
13204
|
|
POL
FNLPPVVAK
27
42
ASDFNLPPVVAKEIV
775
25
39
13205
|
|
POL
FTSAAVKAA
27
42
GSNFTSAAVKAACWW
870
25
39
13206
|
|
POL
LALQDSGLE
27
42
AIHLALQDSOLEVNI
673
15
23
13207
|
|
POL
LPPIVAKEI
27
42
DFNLPPIVAKBIVAS
777
20
31
13208
|
|
POL
LQDSGLEVN
27
42
HLALQDSGLEVNIVT
675
13
20
13209
|
|
POL
FNLPPTVAK
26
41
ASDFNLPPIVAKEIV
775
21
33
13210
|
|
POL
IGQHRAKIE
26
41
DLEIGQIIRAKIEELR
381
23
36
13211
|
|
POL
IIGRNLLTQ
26
41
PVNIIGRNLLTQIGC
168
21
33
13212
|
|
POL
LEVNIVTDS
26
41
DSGLEVNIVTDSQYA
680
26
41
13213
|
|
POL
LRGAKALTD
26
41
CKLLRGAKALTDIVP
469
12
19
13214
|
|
POL
LVSSGIRKV
26
41
VDKLVSSGIRKVLFL
740
25
39
13215
|
|
POL
FLLKLAGRW
25
39
TAYFLLKLAGRWPVK
849
19
30
13216
|
|
POL
LALQDSGSE
25
39
AIIILALQDSGSEVNI
673
08
13
13217
|
|
POL
LQDSGSEVN
25
39
HLALQDSGSEVNIVT
675
08
13
13218
|
|
POL
VKVIHTDNG
25
39
RWPVKVIHTDNGSNF
859
21
33
13219
|
|
POL
WPVKVIHTD
25
39
AGRWPVKVIIITDNGS
857
20
31
13220
|
|
POL
YFLLKLAGR
25
39
ETAYFLLKLAGRWPV
848
24
38
13221
|
|
POL
ICGKKAIGT
24
38
LIEICGKKAIGTVLV
150
12
19
13222
|
|
POL
IVAKEIVAS
24
38
LPPIVAKEIVASCDK
780
22
34
13223
|
|
POL
LRWGFTTPD
24
38
QHLLRWGFTTPDKKH
396
12
19
13224
|
|
POL
LEGKVILVA
23
36
CTHLEGKVILVAVHV
817
23
36
13225
|
|
POL
LKWGFTTPD
23
36
EIILLKWGFTTPDKKH
396
13
20
13226
|
|
POL
VILVAVIVA
23
36
EGKVILVAVHVASGY
821
21
33
13227
|
|
POL
LAWVPAHKG
22
34
KVYLAWVPAHKGIGG
722
20
32
13228
|
|
POL
YDQILIEIC
22
34
VRQYDQILIEICGKK
143
08
13
13229
|
|
POL
YLAWVPAHK
22
34
EKVYLAWVPAHKGIG
721
20
32
13230
|
|
POL
IGQHRTKIE
21
33
DLEIGQIIRTKIEELR
381
19
30
13231
|
|
POL
IGRNLLTQI
21
33
VNIIGRNLLTQIGCT
169
21
33
13232
|
|
POL
LWQRPLVTI
21
33
QITLWQRPLVTIKIG
89
11
17
13233
|
|
POL
VSLTETTNQ
21
33
QKVVSLTETTNQKTE
656
10
16
13234
|
|
POL
VYLAWVPAH
21
33
KEKVYLAWVPAHKGI
720
20
31
13235
|
|
POL
ICGHKAIGT
20
31
LIEICGHKAIGTVLV
150
10
16
13236
|
|
POL
LRGTKALTE
19
30
CKLLRGTKALTEVIP
469
11
17
13237
|
|
POL
LVNQIIEQL
19
30
ESELVNQIIEQLIKK
706
13
20
13238
|
|
POL
LVSQIIEQL
19
30
ESELVSQIIEQLIKK
706
18
28
13239
|
|
POL
YFSVPLDKD
18
29
GDAYFSVPLDKDFRK
301
18
28
13240
|
|
POL
IGRNMLTQI
18
28
VNIIGRNMLTQIGCT
169
12
19
13241
|
|
POL
IKVRQLCKL
18
28
YPGIKVRQLCKLLRG
460
13
20
13242
|
|
POL
LWKGPAKLL
18
28
RDPLWKGPAKLLWKG
983
13
20
13243
|
|
POL
LWQRPLVTV
18
28
QITLWQRPLVTVKIG
89
09
14
13244
|
|
POL
YAGIKVKQL
18
28
SQLYAGIKVKQLCKL
457
18
28
13245
|
|
POL
IWGKTPKFK
17
27
SIVIWGKTPKFKLPI
571
17
27
13246
|
|
POL
LREHLLKWG
17
27
IEELREHLLKWGFTI
391
12
19
13247
|
|
POL
VQPIQLPEK
17
27
KWTVQPIQLPEKDSW
427
13
20
13248
|
|
POL
WQRPLVTIK
17
27
ITLWQRPLVTIKIGG
90
11
17
13249
|
|
POL
IIQAQPDRS
16
25
ALGIIQAQPDRSESF
694
12
19
13250
|
|
POL
LQAIHLALQ
16
25
KTELQAIHLALQDSG
668
15
23
13251
|
|
POL
LVEICTEME
15
24
IKALVEICTEMEKEG
218
15
23
13252
|
|
POL
LRQHLLRWG
15
23
IEELRQHLLRWGITT
391
12
19
13253
|
|
POL
LTQLGCTLN
15
23
RNMLTQLGCTLNFPI
174
10
16
13254
|
|
POL
LYSAGIRKY
15
23
VDKLVSAGIRKVLFL
740
14
22
13255
|
|
POL
VDKLVSAGI
15
23
NEQVDKLVSAGIRKV
737
24
22
13256
|
|
POL
YPGIKVRQL
15
23
SQIYPGIKVRQLCKL
457
12
19
13257
|
|
POL
FRKQNPDIV
14
22
LEPFRKQNPDIVIYQ
357
14
22
13258
|
|
POL
FSFPQITLW
14
22
TVSFSFPQITLWQRP
77
05
10
13259
|
|
POL
FTSITVKAA
14
22
GSNFTSITVKAACWW
870
11
17
13260
|
|
POL
IIASDTQTK
14
22
IIDIIASDIQTKELQ
952
11
17
13261
|
|
POL
LAGRWPVKT
14
22
LLKLAGRWPVKTIHT
853
09
14
13262
|
|
POL
VQKIATESI
14
22
TEAVQKIATESIVIW
561
10
16
13263
|
|
POL
FTIPSTNNE
13
20
YTAFTIPSTNNETPG
316
13
20
13264
|
|
POL
LEDINLPGK
13
20
DTVLEDINLPGKWKP
117
13
20
13265
|
|
POL
LTDIVPLTE
13
20
AKALTDIVPLTEEAE
475
08
13
13266
|
|
POL
LVTIKIGGQ
13
20
QRPLVTIKIGGQLKE
94
13
20
13267
|
|
POL
MRGAHTNDV
13
20
YARMRGAHTNDVKQL
546
12
19
13268
|
|
POL
VKTIHTDNG
13
20
RWPVKTIHTDNGSNF
859
09
14
13269
|
|
POL
VQPIVLPEK
13
20
KWTVQPIVLPEKDSW
427
12
19
13270
|
|
POL
WPVKTIHTD
13
20
AGRWPVKTIHTDNGS
857
09
14
13271
|
|
POL
WQRPLVTVK
13
20
ITLWQRPLVTVKIGG
90
09
14
13272
|
|
POL
WTVQPIVLP
23
20
PDKWTVQPIVLPEKD
425
12
19
13273
|
|
POL
YTAFTIPST
13
20
PRKYTAFTIPSTNNE
313
13
21
13274
|
|
POL
IDIIASDIQ
12
19
ERIIDIIASDIQTKE
950
12
17
13275
|
|
POL
IIDIIASDI
12
19
GERIIDIIASDIQTK
949
12
17
13276
|
|
POL
TVDIIATDI
12
19
GERIVDIIATDIQTK
949
10
16
13277
|
|
POL
LEEINLPGK
12
19
DTVLEEINLPGKWKP
117
11
17
13278
|
|
POL
LQAIYLALQ
12
19
KTELQAIYLALQDSG
668
11
17
13279
|
|
POL
LQKQIIKIQ
12
19
TKELQKQIIKIQNFR
962
09
14
13280
|
|
POL
VDIIATDIQ
12
19
ERIVDIIATDLQTKE
950
10
16
13281
|
|
POL
YDQIPIEIC
12
19
VRQYDQTPIEICGKK
143
05
8
13282
|
|
POL
FNFPQITLW
12
17
VPTFNFPQITLWQRP
79
02
17
13283
|
|
POL
IGRNMLTQL
12
17
VNIIGRNMLTQLOCT
169
10
16
13284
|
|
POL
ISRIGPENP
11
17
EGKISRIGPENPYNT
233
10
16
13285
|
|
POL
LTEVIPLTE
12
17
TKALTEVIPLTEEAE
475
10
16
13286
|
|
POL
MESIVIWGK
11
17
KIAMESIVIWGKTPK
566
07
11
13287
|
|
POL
VPRRKVKII
11
17
IKVVPRRKVKIIRDY
1010
08
13
13288
|
|
POL
VSFSFPQIT
08
17
QGTVSFSFPQITLWQ
75
05
8
13289
|
|
POL
WYQLETEPI
11
17
VKLWYQLETEPIVGA
615
04
6
13290
|
|
POL
YPGIKVKQL
11
17
SQIYPGIKVKQLCKL
457
09
14
13291
|
|
POL
FPQGEAREF
10
16
NLAFPQGEAREFPPE
5
05
8
13292
|
|
POL
LIEALLDTG
10
16
GGQLIEALLDTGADD
103
09
14
13293
|
|
POL
VSLTDTTNQ
10
16
QKVVSLTDTTNQKTE
656
09
14
13294
|
|
POL
WETWWTDYW
10
16
KETWETWWTDYWQAT
587
09
14
13295
|
|
POL
YAKMRTAIT
10
16
TGKYAKMRTAHTNDV
543
09
14
13296
|
|
POL
YKNLKTGKY
10
16
QEPYKNLKTGKYARM
535
03
5
13297
|
|
REV
LQLPPLERL
36
56
PVPLQLPPLERLTLD
74
13
20
13298
|
|
REV
VPLQLPPLE
36
56
AEPVPLQLPPLERLT
72
10
16
13299
|
|
REV
LYQSNPPPS
18
28
IKFLYQSNPPPSPEG
21
04
6
13300
|
|
REV
VRIIKILYQ
16
25
LKAVRIIKILYQSNP
13
06
9
13302
|
|
REV
YQSNPPPSP
12
19
KPLYQSNPPPSPEGT
22
05
8
13302
|
|
REV
LQLPPIERL
11
17
PVPLQLPPIERLRLD
74
04
6
13303
|
|
REV
VPLQLPPIE
12
17
AEPVPLQLPPIERLR
72
04
6
13304
|
|
TAT
WNHPGSQPK
15
23
LEPWNIIPGSQPKTAC
11
11
17
13305
|
|
TAT
FLNKGLGIS
14
22
QVCFLNKGLGISYGR
38
04
6
13306
|
|
TAT
WKHPGSQPK
13
20
LEPWKHPGSQPKTAC
11
11
17
13307
|
|
TAT
YCKKCCFHC
11
17
NNCYCKKCCFIICQVC
26
04
6
13308
|
|
TAT
YCKKCCYHC
11
17
TNCYCKKCCYHCQVC
26
02
3
13309
|
|
TAT
WNHPGSQPT
10
16
LEPWNHPGSQPTTAC
11
07
11
13310
|
|
VIF
MIVWQVDRM
46
72
WQVMIVWQVDRMRIR
5
28
44
13311
|
|
VIF
WQVMIVWQV
43
67
ENRWQVMIVWQVDRM
2
41
64
13312
|
|
VIF
WQVDRMRIR
34
53
MIVWQVDRMRIRTWK
8
14
22
13313
|
|
VIF
LQYLALTAL
33
52
VGSLQYLALTALIKP
147
14
22
13314
|
|
VIF
LGHGVSIEW
31
48
DWHLGHGVSTEWRLR
81
11
17
13315
|
|
VIF
VDRMRIRTW
31
48
VWQVDRMRIRTWNSL
10
15
23
13316
|
|
VIF
YFDCFSESA
28
44
HLYYFDCFSESAIRN
113
08
13
13317
|
|
VIF
YWGLHTGER
28
44
ITTYWGLHTGERDWH
68
14
22
13318
|
|
VIF
IRTWNSLVK
27
42
RMRIRTWNSLVKHHM
15
12
19
13319
|
|
VIF
LGQGVSIEW
26
41
DWHLGQGVSIEWRKK
81
07
11
13320
|
|
VIF
LVKHHMYVS
21
33
WNSLVKHHMYVSKKA
21
07
11
13321
|
|
VIF
IPLGEARLV
19
30
EVIIIPLGEARLVVRT
54
05
8
13322
|
|
VIF
LVKHHMYIS
19
30
WKSLVKHIIMYISGKA
21
05
8
13323
|
|
VIF
YLALTALIK
16
25
SLQYLALTALIKPKK
149
11
17
13324
|
|
VIF
IRTWKSLVK
15
23
RMRIRTWKSLVKHHM
15
14
22
13325
|
|
VIF
LADQLIHLY
15
23
DPDLADQLIHLYYFD
104
07
11
13326
|
|
VIF
LALTALIKP
15
23
LQYLALTALIKPKKI
150
08
13
13327
|
|
VIF
VDPGLADQL
15
23
STQVDPGLADQLIHL
100
04
6
13328
|
|
VIF
LYYFDCFSE
14
22
LIIILYYFDCFSESAI
111
14
22
13329
|
|
VIF
FSESAIRKA
13
20
FDCPSESAIRKAILG
117
10
16
13330
|
|
VIF
LADQLIHMH
13
20
EPGLADQLIHMIIYFD
104
08
13
13331
|
|
VIF
WQVDRMKIR
13
20
LIVWQVDRMKIRTWN
8
09
14
13332
|
|
VIF
PSDSAIRKA
12
19
PDCPSDSAIRKAILG
117
05
8
13333
|
|
VIF
PSESAIRNA
12
19
PDCFSESAIRNAILG
117
12
19
13334
|
|
VIF
IVSPRCEYQ
12
19
LGHIVSPRCEYQAGH
130
06
9
13335
|
|
VIF
LQYLALAAL
12
19
VGSLQYLALAALITP
147
04
6
13336
|
|
VIF
VDRMKIRTW
12
19
VWQVDRMKIRTWNSL
10
12
19
13337
|
|
VIF
YWGLQTGER
12
19
IKTYWGLQTGERDWH
68
08
13
13338
|
|
VIF
IPLGDARLV
11
17
EVHIPLGDARLVITT
54
06
9
13339
|
|
VIF
LQYLALKAL
11
17
VGSLQYLALKALVTP
147
08
13
13340
|
|
VIF
WQVDRMRIN
11
17
MIVWQVDRMRINTWK
8
08
13
13343
|
|
VIF
IKPKKIKPP
10
16
TALIKPKKIKPPLPS
156
08
13
13342
|
|
VIF
VDRMRINTW
10
16
VWQVDRMRINTWKSL
10
09
14
13343
|
|
VPR
IGCQHSRIG
46
72
HFRIGCQHSRIGITR
71
08
13
13344
|
|
VPR
WTLELLEEL
42
69
YNEWTLELLEELKSE
15
12
19
13345
|
|
VPR
ILQQLLFIH
37
58
IIRILQQLLFIHPRI
60
31
48
13346
|
|
VPR
PIHFRIGCQ
30
47
QLLFIHFRIGCQHSR
66
29
45
13347
|
|
VPR
YNEWTLELL
30
47
REPYNEWTLELLEEL
12
27
42
13348
|
|
VPR
FPRPWLHGL
24
38
VRHPPRPWLHGLGQH
31
12
19
13349
|
|
VPR
WEGVEAIIR
18
28
GDTWEGVEAIIRILQ
51
14
22
13350
|
|
VPR
LEELKSEAV
16
25
LELLEELKSEAVRHF
20
15
23
13351
|
|
VPR
WAGVEAIIR
16
25
GDTWAOVEAIIRILQ
51
15
23
13352
|
|
VPR
YGDTWAGVE
16
25
YETYGDTWAGVEAII
47
16
25
13353
|
|
VPR
IGCRHSRIG
12
19
HPRIGCRHSRTGITR
71
03
5
13354
|
|
VPR
FIHPRIGCR
11
17
QLLPIHPRIGCRHSR
66
11
17
13355
|
|
VPR
FVHPRIGCQ
11
17
QLLFVHPRIGCQHSR
66
10
16
13356
|
|
VPR
YGDTWTGVE
11
17
YETYGDTWTGVEAII
47
04
6
13357
|
|
VPR
FPRIWLHSL
10
16
VRIIPPRIWLHSLGQH
31
05
8
13358
|
|
VPR
WALELLEEL
09
15
YNEWALELLEELKNE
15
03
5
13359
|
|
VPU
LVTLLSSSK
01
50
EEWLVTLLSSSKLDQ
87
01
2
13360
|
|
VPU
VTLLSSSKL
01
50
EWLVTLLSSSKLDQG
89
01
2
13361
|
|
VPU
IIAIVVWTI
23
36
VVAIIAIVVWTIVFI
20
02
3
13362
|
|
VPU
VGYRIVIVA
01
33
LAKVDYRIVIVAPIV
5
01
25
13363
|
|
VPU
LRQRKIDRL
17
27
RKILRQRKIDRLIDR
44
11
17
13364
|
|
VPU
IVVWTIVFI
15
23
IIAIVVWTIVFIEYR
27
07
11
13365
|
|
VPU
VVWTIVFIE
14
22
IAIVVWTIVFIEYRK
28
06
9
13366
|
|
VPU
IEYRKILRQ
13
21
IVFIEYRKILRQRKI
36
07
11
13367
|
|
VPU
ILAIVALVV
11
17
SLYILAIVALVVAII
3
01
2
13368
|
|
VPU
WTIVFIEYR
10
16
IVVWTIVPIEYRKIL
30
05
8
13369
|
|
VPU
LAIVALVVA
09
15
LQILAIVALVVAGII
4
02
3
13370
|
|
TABLE XIXb
|
|
|
HIV DR Super Motif Peptides with Binding Information
|
Core
|
Sequence
Exemplary Sequence
DR1
DR2 wβ1
DR2w2β2
DR3
DR4w4
DR4w15
DR5w11
DR5w12
DR6w19
DR7
DR8w2
DR9
DRw53
SEQ ID NO.
|
|
VSTQLLLNG
KPVVSTQLLLNGSLA
12864
|
|
VVSTQLLLN
IKPVVSTQLLLNGSL
12865
|
|
LTVWGIKQL
LLQLTVWGIKQLQAR
0.0840
0.0096
0.0190
0.0750
0.0180
12866
|
|
LLSGIVQQQ
ARQLLSGIVQQQSNL
12867
|
|
WATHACVPT
HNVWATHACVPTDPN
12868
|
|
LGAAGSTMG
LGFLGAAGSTMGAAS
12869
|
|
VRQGYSPLS
VNRVRQGYSPLSFQT
0.0032
−0.0014
0.0230
−0.0010
−0.0007
12870
|
|
LLLNGSLAE
STQLLLNGSLAEEEV
12871
|
|
VKLTPLCVT
KPCVKLTPLCVTLNC
12872
|
|
LRAIEAQQH
NNLLRAIEAQQIILLQ
0.0280
0.0150
0.0150
12873
|
|
VSTVQCTHG
CKNVSTVQCTHGIKP
12874
|
|
LGIWGCSGK
QQLLGIWGCSGKLIC
12875
|
|
LWDQSLKPC
IISLWDQSLKPCVKL
0.0057
0.0061
0.0096
0.0059
0.0012
12876
|
|
LGFLGAAGS
AVFLGFLGAAGSTMG
12877
|
|
VWATHACVP
VHNVWATHACVPTDP
12878
|
|
WGIKQLQAR
LTVWGIKQLQARVLA
12879
|
|
LWYIKIFIM
TNWLWYIKIFIMIVG
12880
|
|
FCASDAKAY
TILFCASDAKAYDTE
12881
|
|
IVGGLTGLR
FIMIVGGLIGLRIVF
12882
|
|
IFIMIYGGL
YIKIFIMIVGGLIGL
12883
|
|
VYYGVPVWK
WVTVYYGVPVWKEAT
0.0790
6.1000
0.0700
0.0043
0.0180
8.2000
0.0010
0.0098
−0.0004
0.0310
0.0049
0.4600
12884
|
|
IKQLQARVL
VWGIKQLQARVLAVE
12885
|
|
IKIPIMIVG
LWYIKIPIMIVGGLI
12886
|
|
MGAASITLT
GSTMGAASITLTVQA
12887
|
|
YKIFINTIV
WLWYIKIFIMIVGGL
12888
|
|
ITGLLLTRD
SSNITGLLLTRDGGK
12889
|
|
IPIHYCAPA
FEPIPIHYCAPAGFA
12890
|
|
MIVGGLIGL
IFIMIVGGLIGLRIV
12891
|
|
VQARQLLSG
TLTVQARQLLSOIVQ
12892
|
|
FEPIPIHYC
KVSFEPIPIHYCAPA
12893
|
|
LRSLCLFSY
WDDLRSLCLPSYHRL
12894
|
|
MWKNNMVEQ
NFNMWKNNMVEQMHE
12895
|
|
VHWVWATHA
DTEVHNVWATHACVP
12896
|
|
WKNNMVEQM
FNMWKNNMVEQMNED
12897
|
|
YYGVPVWKE
VTVYYGVPVWKEATI
0.0087
0.0270
0.0071
0.0021
0.0160
12898
|
|
LLQLTVWGI
QQHLLQLTVWGTKQL
1.1000
0.7500
0.0580
−0.0043
0.0330
0.2700
0.0036
0.4900
0.0180
0.3900
0.0210
0.5100
12899
|
|
IEPLGVAPT
VVKIEPLGVAPTKAK
12900
|
|
IKPVVSTQL
THGIKPVVSTQLLLN
12901
|
|
LQARVLAVE
IKQLQARVLAVERYL
12902
|
|
WDDLRSLCL
ALAWDDLRSLCLFSY
12903
|
|
ITNIHTPHR
SRPIINIHTPHREKR
12904
|
|
INIHTPHRE
RPHNIIITPHREKRA
12905
|
|
ITQACPKVS
TSVITQACPKVSFEP
12906
|
|
IVQQQSNLL
LSGIVQQQSNLLRAI
12907
|
|
LGNNSTNST
NKTLGNNSTNSTLGN
12908
|
|
VISTRTHRE
ARPVISTRTHRBKRA
12909
|
|
WRWGTLFLG
QNLWRWGTLFLGMLM
12910
|
|
WRWGTMLLG
QHLWRWGTMLLGMLM
12911
|
|
FAVLSIVNR
RIVFAVLSIVHRVRQ
12912
|
|
LLNGSLAEE
TQLLLNGSLABEEVV
12913
|
|
LTPLCVTLN
CVKLTPLCVTLNCTD
12914
|
|
LYKYKVVKI
RSELYKYKVVKIEPL
0.0066
0.0320
0.0014
0.0011
0.0190
0.0042
0.0100
0.1800
0.1100
0.1700
12915
|
|
VPWNSSWSN
TTNVPWNSSWSNKSL
12916
|
|
YRLINCNTS
YKEYRLINCNTSAIT
12917
|
|
IIIYCAPAGF
PIPIHYCAPAGFAIL
12918
|
|
LKDQQLLGI
ERYLKDQQLLGIWGC
12919
|
|
YKYKVVKIE
SELYKYKVVKIEPLG
12920
|
|
IRPVVSTQL
TIIGIRPVVSTQLLLN
12921
|
|
LDKWASLWN
LLALDKWASLWNWFD
12922
|
|
LRIVFAVLS
LIGLRIVPAVLSIVN
12923
|
|
LNGSLAEEE
QLLLNGSLAEEEVVI
12924
|
|
YKVVKJEPL
LYKYKVVKIEPLGVA
12925
|
|
LKGLRLGWE
RSSLKGLRLGWEGLK
12926
|
|
FSYHRLRDL
LCLFSYHRLRDLLLI
12927
|
|
INCTRPNNN
SVELNCTRPNNNTRK
12928
|
|
VVKIEPLGV
KYKVVKIEPLGVAPT
12929
|
|
WKEATTTLF
VPVWKEATTTLFCAS
0.0260
−0.0002
0.0520
−0.0030
0.1100
0.0900
0.0021
−0.0045
0.0004
0.0630
0.0086
0.4700
12930
|
|
IGLRIVFAV
GGLIGLRIVFAVLSI
12931
|
|
FPYCNTSGL
GGEFFYCNTSGLENS
12932
|
|
FGLGALFLG
RAAFGLGALFLGFLG
12933
|
|
FYCNTSGLF
GEFFYCNTSGLFNST
12934
|
|
LIGLRIVFA
VGGLIGLRIVFAVLS
12935
|
|
VGLGAVFLG
KRAVGLGAVFLGFLG
12936
|
|
VGLGMLELG
KRAVGLGMLFLGVLS
12937
|
|
ICTTAVPWN
GKLICTTAVPWNSSW
12938
|
|
ICITNVPWN
GKLICTTNVPWNSSW
12939
|
|
LGVAPTKAK
IEPLGVAPTKAKRRV
12940
|
|
LICTTAVPW
SGKLICTTAVPWNSS
12941
|
|
LRDQQLLGI
ERYLRDQQLLGIWGC
12942
|
|
VFLGFLGAA
LGAVFLGFLGAAGST
12943
|
|
FSYHRLRDF
LCLFSYIIRLRDFILI
12944
|
|
IPIHYCTPA
FEPIPIHYCTPAGFA
12945
|
|
IVFAVLSIV
GLRIVFAVLSIVNRV
12946
|
|
VFAVLSIVN
LRIVFAVLSIVNRVR
12947
|
|
VPWNASWSN
TTAVPWNASWSNKSL
12948
|
|
IGLRIIFAV
GGLIGLRIIFAVLSI
12949
|
|
IRQAHCNIS
IGDIRQAHCNISRAK
12950
|
|
VAPTKAKRR
PLGVAPTKAKRRVVQ
12951
|
|
FNGTGPCKN
DKKFNGTGPCKNVST
12952
|
|
IGPGQTFYA
SVRIGPGQTFYATGD
12953
|
|
IGSGQAFYV
RYSIGSGQAFYVTGK
12954
|
|
IRYLNLVNQ
QTAIRYLNLVNQTEN
12955
|
|
LIGLRIIFA
VGGLIGLRIIFAVLS
12956
|
|
LLQYWSQEL
WWNLLQYWSQELKNS
12957
|
|
LRNLCLFSY
WDDLRNLCLFSYHRL
12958
|
|
LYSGELALA
SIRLVSGFLALAWDD
12959
|
|
VSGFLALAW
IRLVSGFLALAWDDL
12960
|
|
FDPYPIHYC
KVTFDPIPIHYCTPA
12961
|
|
IIFAVLSIV
GLRIIFAVLSIVNRV
12962
|
|
LINCNTSAI
EYRLINCNTSAITQA
12963
|
|
LLNATAIAV
AVSLLNATAIAVAEG
12964
|
|
LRIIFAVLS
LIGLRIIFAVLSIVN
12965
|
|
VITQACPKV
NTSVITQACPKVSFE
12966
|
|
YWWNLLQYW
VLKYWWNLLQYWSQE
12967
|
|
FAILKCNDK
PAGFAILKCNDKKFN
12968
|
|
IFAVLSIVN
LRIIFAVLSIVNRVR
12969
|
|
INCNTSAIT
YRLINCNTSALTQAC
12970
|
|
LNATAIAVA
VSLLNATAIAVAEGT
12971
|
|
WNSSWSNKS
NVPWNSSWSNKSLDE
12972
|
|
WNASWSNKS
NVPWNASWSNKSYED
12973
|
|
ICITIVPWN
GKLICITTVPWNASW
12974
|
|
LLKLTVWGI
QQHLLKLTVWGIKQL
12975
|
|
LYKYKVVEI
RSELYKYKVVEIKPL
12976
|
|
MFLGFLGAA
LGAMFLGFLGAAGST
12977
|
|
MHSFNCGGE
EIVMHSFNCGGEFFY
12978
|
|
YWSQELKNS
LLQYWSQELKNSAVS
12979
|
|
IGAVELGFL
AVGIGAVFLGFLGAA
12980
|
|
LIAARTVEL
DFILIAARTVELLGH
12981
|
|
LICTIIVPW
SGKLICTITVPWNAS
12982
|
|
LLNGSLAEG
TQLLLNGSLAEGEII
12983
|
|
YWGQELKNS
LVWYWGQELKNSAIS
12984
|
|
IAARTVELL
FILIAARTVELLGHS
12985
|
|
LFLGFLGAA
IGALPLGFLGAAGST
12986
|
|
LKNSAVSLL
SQELKNSAVSLLNAT
12987
|
|
VGIGAVELG
KRAVGIGAVILGFLG
12988
|
|
VSLLNATAI
NSAVSLLNATAIAVA
12989
|
|
YATGDICGD
QTFYATGDIIGDIRQ
12990
|
|
IAIAVAEGT
LDIIAIAVAEGTDRI
12991
|
|
IHYCTPAGF
PIPIHYCTPAGFAIL
12992
|
|
ILGLVIICS
GTLILGLVIICSASN
12993
|
|
IWNNMTWME
VDEIWNNMTWMEWER
12994
|
|
LGLVIICSA
TLILGLVIICSASNN
12995
|
|
LRDFILTAA
YHRLRDFILIAARTV
12996
|
|
LTPLCVTLD
CVKLTPLCVTLDCHN
12997
|
|
MLQLTVWGI
QQHMLQLTVWGIKQL
12998
|
|
VEINCTRPN
NESVEINCTRPNNNT
12999
|
|
VRQLLSGIV
TVQVRQLLSGIVQQQ
13000
|
|
LILGLVIIC
WGTLILGLVIICSAS
13001
|
|
VGGHQAAMQ
LNTVGGIIQAAMQMLK
13002
|
|
LLVQNANPD
TETLLVQNANPDCKT
13003
|
|
VQNANPDCK
TLLVQNANPDCKTIL
13004
|
|
LGLNKIVRM
WIILGLNKIVRMYSP
0.0400
0.3300
0.1100
1.1000
0.0310
0.0290
0.3700
0.2400
1.8000
0.0088
0.2800
0.0024
13005
|
|
LSEGATPQD
FSALSEGATPQDLNT
13006
|
|
WIILGLNKI
YKRWIILGLNKIVRM
1.2000
1.6000
0.7800
1.1000
0.0740
0.2400
0.3100
1.5000
4.0000
0.1200
0.5400
0.6200
13007
|
|
LEEMMTACQ
GATLEEMMTACQGVG
13008
|
|
YKRWIILGL
GEIYKRWIILGLNKI
0.0610
0.0660
0.0890
−0.0043
0.0300
0.1000
0.0940
0.1800
0.0356
0.1300
0.7800
0.1400
13009
|
|
IYKRWIILG
VGEIYKRWIILGLNK
13010
|
|
VSQNYPIVQ
SSQVSQNYPIVQNLQ
13011
|
|
WEKIRLRPG
LDKWEKIRLRPGGKK
13012
|
|
IAGTTSTLQ
GSDIAGTTSTLQEQI
13013
|
|
WASRELERF
HLVWASRELERFALN
13014
|
|
IPMFSALSE
PEVIPMFSALSEGAT
13015
|
|
MFSALSEGA
VIFMFSALSEGATPQ
0.0085
−0.0014
0.0058
−0.0010
−0.0007
13016
|
|
VIFMFSALS
SPEVIFMFSALSEGA
0.0460
0.0280
0.0034
−0.0043
0.1600
0.0075
−0.0045
0.0007
−0.0007
0.0130
0.0130
13017
|
|
MYSPVSILD
IVRMYSPVSILDIRQ
13018
|
|
IVRMYSPVS
LNKIVRMYSPVSILD
13019
|
|
VRMYSPVSI
NKIVRMYSPVSILDI
13020
|
|
YSPVSLLDI
VRMYSPVSILDIRQG
13021
|
|
MTETLLVQN
KNWMTETLLVQNANP
13022
|
|
WMTETLLVQ
VKNWMTETLLVQNAN
0.0033
0.0130
0.0077
−0.0043
0.0480
−0.0010
−0.0045
0.0032
0.0280
0.0008
0.0053
13023
|
|
ISPRTLNAW
HQAISPRTLNAWVKV
13024
|
|
VKNWMTETL
TQEVKNWMTETLLVQ
13025
|
|
IKCFNCGKE
QKRIKCFNCGKEGHL
13026
|
|
IPVGEIYKR
NPPIPVGEIYKRWII
13027
|
|
YTAVFMQRG
KGGYTAVFMQRGQNP
13028
|
|
VATLYCVHQ
YNTVATLYCVHQRIE
13029
|
|
WDRLHPVHA
AAEWDRLHPVHAGPI
13030
|
|
FLQSRPEPT
PGNFLQSRPEPTAPP
0.0970
0.0170
0.0190
0.0015
0.0130
13031
|
|
FKTLRAEQA
DRFIKTLRAEQATQE
13032
|
|
MVHQAISPR
QGQMVHQAISPRTLN
0.0690
0.1400
1.5000
0.0170
0.8300
0.0950
−0.0010
0.0048
0.0085
0.550
0.0067
0.6400
13033
|
|
VHQAISPRT
GQMVHQAISPRTLNA
0.0003
0.0023
0.0034
−0.0010
−0.0007
13034
|
|
YKTLRAEQA
DRFYKTLRAEQASQE
0.0530
0.0016
0.0500
0.1500
0.0430
−0.0001
0.0028
−0.0015
13035
|
|
VSILDIRQG
YSPVSILDIRQGPKE
13036
|
|
LAEAMSQVT
ARVLAEAMSQVTNSA
13037
|
|
LGKIWPSHK
ANFLGKTWPSHKGRP
13038
|
|
VKCFNCGKE
RKTVKCFNCGKEGHI
13039
|
|
YNTVATLYC
RSLYNTVAILYCVHQ
13040
|
|
LHPVHAGPI
WDRLHPVHAGPIAPG
13041
|
|
LYNTVATLY
LRSLYNTVATLYCVH
13042
|
|
MTDTLLVQN
KNWMTDTLLVQNANP
13043
|
|
WMTDTLLVQ
VKNWMTDTLLVQNAN
13044
|
|
IEVKDTKEA
HQRIEVKDTKEALDK
13045
|
|
LQGQMVHQA
VQNLQGQMVHQAISP
13046
|
|
MTNNPPIPV
IGWMTNNPPIPVGEI
13047
|
|
WMTNNPPIP
QIGWMTNNPPIPVGE
13048
|
|
IAPGQMREP
AGPIAPGQMREPRGS
13049
|
|
VHAGPIAPG
LHPVHAGPIAPGQMR
13050
|
|
LGPGATLEE
LRALGPGATLEEMMT
13051
|
|
VHAGPIPPG
VHPVHAGPIPPGQMR
13052
|
|
IPPGQMREP
AGPIPPGQMREPRGS
13053
|
|
LSPRTLNAW
HQALSPRTLNAWVKV
13054
|
|
YRLKHLVWA
KKKYRLKIILVWASRE
13055
|
|
LGPAATLEE
LKALGPAATLEEMMT
13056
|
|
LKALGPAAT
KTILKALGPAATLEE
0.0760
0.0100
−0.0023
−0.0010
0.0006
13057
|
|
LKDKEPPLA
QEQLKDKEPPLASLR
13058
|
|
LSGGKLDAW
ASVLSGGKLDAWEKI
13059
|
|
MTSNPPIPV
IGWMTSNPPIPVGEI
13060
|
|
VKNWMTDTL
TQDVKNWMTDTLLVQ
13061
|
|
VSILDIKQG
YSPVSILDIKQGPKE
13062
|
|
WMTSNPPIP
QIGWMTSNPPIPVGE
13063
|
|
FNTVATLYC
KSLENTVATLYCVHQ
13064
|
|
IPMFTALSE
PEVIPMPTALSEGAT
13065
|
|
LASLKSLFG
LYPLASLKSLFGNDP
13066
|
|
LERFAVNPG
SRELERFAVNPGLLE
13067
|
|
LFNTVATLY
LRSLFNTVATLYCVH
13068
|
|
MFTALSEGA
VIPMFTALSEGATPQ
13069
|
|
WDRVHPVHA
AAEWDRVHPVHAGPI
13070
|
|
IVRMYSPTS
LNKIVRMYSPTSILD
13071
|
|
LERFALNPG
SRELERFALNPGLLE
13072
|
|
LQEQIAWMT
TSTLQEQIAWMTGNP
13073
|
|
VHPVHAGPI
WDRVHPVHAGPIPPG
13074
|
|
VIFMFTALS
SPEVIPMFTALSEGA
13075
|
|
VRMYSPTSI
NKIVRMYSPTSILDI
13076
|
|
LGKTWPSNK
ANFLGKIWPSNKGRP
13077
|
|
LTSLKSLFG
LYPLTSLKSLFGNDP
13078
|
|
MYSPTSILD
IVRMYSPTSILDIRQ
13079
|
|
YKLKHTVWA
KKKYKLKHIVWASRE
13080
|
|
YSPTSILDI
VRMYSPTSILDIRQG
13081
|
|
LTSLRSLFG
LYPLTSLRSLFGNDP
13082
|
|
MMLNIVGGH
DLNMMLNIVGGNQAA
13083
|
|
IDVKDTKEA
HQRIDVKDTKEALDK
13084
|
|
IGWMTSNPP
QEQIGWMTSHPPIPV
13085
|
|
IPVGDIYKR
NPPIPVGDIYKRWII
13086
|
|
LYPLASLKS
DKELYPLASLKSLFG
13087
|
|
VRQALSPRT
GQMVHQALSPRTLNA
13088
|
|
VNPGLLETS
RFAVNPGLLETSEGC
13089
|
|
YPLASLKSL
KELYPLASLKSLFGN
13090
|
|
FLQNRPEPT
PGNFLQNRPEPTAPP
13091
|
|
IMMQKSNFK
AAAIMMQKSNFKGPR
13092
|
|
LAEAMSQVQ
ARVLAEAMSQVQQSN
13093
|
|
LGKIWPSSK
ANFLGKIWPSSKGRP
13094
|
|
LNPGLLETA
RFALNPGLLETAEGC
13095
|
|
YPLASLRSL
KELYPLASLRSLFGN
13096
|
|
WQNYTPGPG
FPDWQNYTPGPGIRY
13097
|
|
VRPQVPLRP
GFPVRPQVPLRPMTY
13098
|
|
VPLRPMTYK
RPQVPLRPMTYKGAF
13099
|
|
LTFGWCFKL
RYPLTFGWCFKLVPV
13100
|
|
ILDLWVYHT
RQEILDLWVYHTQGY
13101
|
|
WCFKLVPVD
TFGWCPKLVPVDPRE
13102
|
|
LWVYHTQGY
ILDLWVYHTQGYFPD
13103
|
|
WSKSSIVGW
GGKWSKSSIVGWPAI
13104
|
|
ILDLWVYNT
RQDILDLWVYNTQGY
13105
|
|
LLHPMSQHG
NNCLLHPMSQHGMDD
13106
|
|
LLHPICQHG
NNSLLHPICQHGMED
13107
|
|
IRYPLTFGW
GPGIRYPLTFGWCFK
13108
|
|
ITSSNTAAT
HGAITSSNTAATNAD
13109
|
|
LEKHGAITS
SRDLEKHGAITSSNT
13110
|
|
LWVYHTQGF
ILDLWVYHTQGFFPD
13111
|
|
MTYKGAFDL
LRPMTYKGAFDLSFF
13112
|
|
LVPVDPREV
CFKLVPVDPREVEEA
13113
|
|
VGWPAIRER
SSIVGWPAIRERMRR
13114
|
|
WCFKLVPVE
TFGWCFKLVPVEPEK
13115
|
|
FDSRLAFHH
EWRFDSRLAFHHVAR
13116
|
|
FKLVPVDPR
GWCFKLVPVDPRBVE
13117
|
|
VPLRPMTFK
RPQVPLRPMTFKGAF
13118
|
|
LLDTGADDT
KEALLDTGADDTVLE
0.0001
−0.0015
−0.0023
−0.0010
−0.0003
13119
|
|
WMGYELHPD
PFLWMGYELHPDKWT
13120
|
|
YQYNVLPQG
GIRYQYNVLPQGWKG
13121
|
|
FRKYTAFTI
DKDFRKYTAFTIPSI
13122
|
|
WTVNDIQKL
KDSWTVNDIQKLVGK
0.0027
−0.0014
−0.0026
0.1200
−0.0005
13123
|
|
LDCTHLEGK
IWQLDCTIILEGKIIL
13124
|
|
LDVGDAYFS
VTVLDVGDAYFSVPL
0.0003
−0.0014
−0.0026
−0.0007
−0.0005
13125
|
|
MDDLYVGSD
YQYMDDLYVGSDLEI
0.0006
−0.0014
−0.0160
0.0036
−0.0006
−0.0005
13126
|
|
VIPAETGQE
EAEVIPAETGQETAY
13127
|
|
WKGEGAVVI
KLLWKGEGAVVIQDN
0.4600
0.0011
0.0058
−0.0043
0.0750
0.0200
0.0060
−0.0045
0.0450
0.2400
0.0450
0.2100
13128
|
|
WQLDCTHLE
PGIWQLDCTHLEGKI
13129
|
|
VDFRELNKR
RKLVDFRELNKRTQD
13130
|
|
WKPKMIGGI
PGKWKPKMIGGIGGF
13131
|
|
IWQLDCTHL
SPGIWQLDCTHLEGK
0.0013
−0.0021
0.0990
−0.0006
−0.0009
13132
|
|
VAVHVASGY
IILVAVIIVASGYIEA
13133
|
|
WKGSPAIFQ
PQGWKGSPAIFQSSM
0.0010
−0.0014
−0.0026
−0.0007
0.0087
13134
|
|
IGGYSAGER
KGGIGGYSAGERIID
13135
|
|
YALGIIQAQ
DSQYALGIIQAQPDK
13136
|
|
FWEVQLGIP
TQDFWEVQLGIPHPA
13137
|
|
IKKKDSTKW
VFAIKKKDSTKWRKL
13138
|
|
LGIIQAQPD
QYALGIIQAQPDKSE
13139
|
|
LGIPHPAGL
EVQLGIPHPAGLKKK
0.0020
0.1300
−0.0026
−0.0007
−0.0005
13140
|
|
VNTPPLVKL
WEFVNTPPLVKLWYQ
0.6900
0.0410
9.5000
0.0220
1.8000
1.9000
0.0630
0.2200
0.0390
1.7000
0.1400
1.9000
13141
|
|
VTVLDVGDA
KKSVTVLDVGDAYFS
0.0019
−0.0014
0.0065
0.0030
−0.0005
13142
|
|
FPISPIETV
TLNFPISPIETVPVK
0.0190
0.0003
−0.0014
−0.0043
0.0350
−0.0007
0.0370
0.0150
0.0640
−0.0005
0.0016
13143
|
|
ISPIETVPV
NFPISPIETVPVKLK
0.0480
0.0013
0.0022
−0.0043
0.0810
0.0095
−0.0007
0.0460
0.0190
0.1500
0.0008
0.0046
13144
|
|
FVNTPPLVK
EWEFVNTPPLVKLWY
13145
|
|
LNFPISPIE
GCTLNFPISPIETVP
0.0014
−0.0014
−0.0026
−0.0006
0.0380
13146
|
|
WEFVNTPPL
IPEWEFVNTPPLVKL
1.1000
0.0089
1.8000
0.0920
0.6600
1.6000
0.0830
0.0540
0.0230
1.4000
0.2600
2.6000
13147
|
|
IQNFRVYYR
ITKIQNFRVYYRDSR
13148
|
|
LVGPTPVNI
GTVLVGPTPVNIIGR
0.0066
0.0061
−0.0014
−0.0043
−0.0026
0.0043
−0.0045
0.0290
0.0820
−0.0005
0.0180
13149
|
|
VQLGIPHPA
FWEVQLGIPHPAGLK
0.0240
−0.0014
0.0033
−0.0006
0.0024
13150
|
|
WQATWIPEW
TEYWQATWIPEWEFV
13151
|
|
IETVPVKLK
ISPIETVPVKLKPGM
0.0019
0.0140
−0.0026
−0.0007
0.0150
13152
|
|
IGTVLVGPT
KKAIGTVLVGPTPVN
13153
|
|
LVAVHVASG
KIILVAVHVASGYIE
13154
|
|
VLVGPTPVN
IGTVLVGPTPVNIIG
0.0120
0.0170
−0.0003
0.0008
0.0030
−0.0004
0.0400
0.0710
−0.0003
0.0320
13155
|
|
YIEAEVIPA
ASGYIEAEVIPAFTG
0.0230
−0.0003
−0.0021
−0.0043
0.2300
0.0020
−0.0045
0.0400
0.0710
−0.0003
0.0320
13156
|
|
YVGSDLEIG
DDLYVGSDLEKSQHR
13157
|
|
MDGPKVKQW
KPGMDGPKVKQWPLT
13158
|
|
VASGYIEAE
AVIIVASGYIEAEVIP
13159
|
|
VGPTPVNII
TVLVGPTPVNIIGRN
0.0010
−0.0014
−0.0026
0.0035
0.0150
13160
|
|
VKQWPLTEE
GPKVKQWPLTEEKIK
13161
|
|
VYYRDSRDP
NFRVYYRDSRDPIWK
13162
|
|
WGFTTPDKK
LLRWGFTTPDKKHQK
13163
|
|
VIYQYMDDL
PEIVIYQYMDDLYVG
13164
|
|
LKKKKSVTV
PAGLKKKKSVTVLDV
0.0060
−0.0014
−0.0026
−0.0006
0.0140
13165
|
|
VPRRKAKII
IKVVPRRKAKIIRDY
0.0003
0.0700
−0.0024
2.5000
0.0030
13166
|
|
FPQITLWQR
SFSFPQITLWQRPLV
0.0027
0.0130
0.0006
13167
|
|
VIWGKTPKF
ESIVIWGKTPKFRLP
13168
|
|
YVDGAANRE
ETFYVDGAANRETKL
13169
|
|
FKNLKTGKY
QEPPKNLKTGKYAKM
13170
|
|
IQTKELQKQ
ATDIQTKELQKQITK
13171
|
|
YGKQMAGDD
IRDYGKQMAGDDCVA
13172
|
|
WRAMASDFN
HSNWRAMASDFNLPP
0.1500
0.0004
0.1600
−0.0030
4.7000
2.6000
0.2100
−0.0045
0.0008
0.0530
0.0250
0.0860
13173
|
|
ISKJGPENP
EGKISKIGPENPYNT
13174
|
|
LTQIGCTLN
RNLLTQIGCTLNFPI
13175
|
|
IIQAQPDKS
ALGIIQAQPDKSESE
0.0001
−0.0014
−0.0026
−0.0007
−0.0005
13176
|
|
LPEKDSWTV
PIVLPEKDSWTVNDI
13177
|
|
FQSSMTKIL
PAIFQSSMTKILEPF
0.0320
0.0320
0.0200
−0.0043
0.0058
0.6500
0.0660
−0.0045
0.1100
0.7300
0.0140
0.9100
13178
|
|
FTIPSINNE
YTAFTIPSTNNSTPG
13179
|
|
IFQSSMTKI
SPAIFQSSMTKILEP
0.0140
0.0420
0.0300
−0.0043
0.0140
0.3500
0.0270
0.0122
0.2800
0.3700
0.0150
2.3000
13180
|
|
IIEQLIKKE
VSQIIEQLIKKEKVY
13181
|
|
LSWVPAHKG
KVYLSWVPAHKGIGG
13182
|
|
YLSWVPAHK
EKVYLSWVPAHKGIG
13183
|
|
YTAFTIPSI
FRKYTAFTIPSINNE
0.0270
0.1300
0.0048
−0.0043
0.1700
0.2800
0.0110
0.0089
−0.0004
0.8400
0.0610
1.900
13184
|
|
IIATDIQTK
ITDIIATDIQTKELQ
13185
|
|
IWKGPAKLL
RDPIWKGPAKLLWKG
13186
|
|
LQKQITKIQ
TKELQKQITKIQNFR
0.0071
0.0210
0.0350
0.0540
0.0200
0.0530
0.0050
0.0055
0.0250
0.0028
13187
|
|
LKEALLDTG
GGQLKEALLDTGADD
0.0001
−0.0021
−0.0024
−0.0005
−0.0009
13188
|
|
VYLSWVPAH
KEKVYLSWVPAHKGI
13189
|
|
FILKLAGRW
TAYFILKLAGRWPVK
13190
|
|
LEGKIILVA
CTHLEGKIILVAVHV
13191
|
|
YFILKLAGR
ETAYFILKLAGRWPV
13192
|
|
IILVAVHVA
EGKIILVAVHVASGY
13193
|
|
IWGKTPKFR
SIVIWGKTPKFRLPI
13194
|
|
LAGRWPVKV
ILKLAGRWPVKVIHT
13195
|
|
VVAKEIVAS
LPPVVAKEIVASCDK
0.0001
−0.0021
0.0043
−0.0010
−0.0009
13196
|
|
IDIIATDIQ
ERIIDIIATDIQTKE
13197
|
|
IIDIIATDI
GERIIDIIATDIQTK
13198
|
|
IIGRNMLTQ
PVNIIGRNMLTQIGC
13199
|
|
IKVKQLCKL
YAGIKVKQLCKLLRG
13200
|
|
VDKLVSSGI
NEQVDKLVSSGIRKV
13201
|
|
IVGAETFYV
KEPIVGAETFYVDGA
13202
|
|
LPPVVAKEI
DFNLPPVVAKEIVAS
0.0042
−0.0021
−0.0024
0.0036
0.0530
13203
|
|
WTVQPIQLP
PDKWTVQPIQLPEKD
13204
|
|
FNLPPVVAK
ASDFNLPPVVAKEIY
0.0026
−0.0021
−0.0028
−0.0006
0.0840
13205
|
|
FTSAAVKAA
GSNFTSAAVKAACWW
13206
|
|
LALQDSGLE
AIHLALQDSGLEVNI
13207
|
|
LPPIVAKEI
DFNLPPIVAKEIVAS
13208
|
|
LQDSGLEVN
HLALQDSGLEVNIVT
13209
|
|
FNLPPIVAK
ASDFNLPPIVAKEV
13210
|
|
IGQHRAKIE
DLEIGQHRAKIEELR
13211
|
|
IIGRNLLTQ
PVNIIGRNLLTQIGC
0.0059
−0.0014
0.0043
0.0990
−0.0005
13212
|
|
LEVNIVTDS
DSGLEVNIVTDSQYA
0.0001
−0.0014
0.0350
−0.0007
−0.0005
13213
|
|
LRGAKALTD
CKLLRGAKALTDIVP
13214
|
|
LVSSGIRKV
VDKLVSSGIRKVLFL
13215
|
|
FLLKLAGRW
TAYFLLKLAGRWPVK
13216
|
|
LALQDSGSE
AIHLALQDSGSEVNI
13217
|
|
LQDSGSEVN
HLALQDSGSEVNIVT
13218
|
|
VKVIHTDNG
RWPVKVIHTDNGSNF
13219
|
|
WPVKVIHTD
AGRWPVKVIHTDNGS
13220
|
|
YFLLKLAGR
ETAYFLLKLAGRWPV
0.0610
0.0210
0.0041
13221
|
|
ICGKKAIGT
LIEICGKKAIGTVLV
13222
|
|
IVAKEIVAS
LPPIVAKEIVASCDK
13223
|
|
LRWGFTTPD
QHLLRWGFTTPDKKH
13224
|
|
LEGKVILVA
CTHLEGKVILVAVIIV
13225
|
|
LKWGFTTPD
EHLLKWGFTIPDKKH
13226
|
|
VILVAVHVA
EGKVILVAVHVASGY
13227
|
|
LAWVPAHKG
KVYLAWVPAHKGIGG
0.6000
0.3700
0.8200
0.0049
0.3200
0.2300
0.2800
0.0240
0.0014
0.1400
0.2500
0.3000
13228
|
|
YDQILIEC
VRQYDQILIEICGKK
13229
|
|
YLAWVPAHK
EKVYLAWVPAHKGIG
1.4000
0.4400
4.1000
0.0930
5.4000
1.4000
0.5400
0.0460
0.0010
1.4000
1.6000
0.5200
13230
|
|
IGQHRTKIE
DLEIGQHRTKIEELR
13231
|
|
IGRNLLTQI
VNIIGRNLLTQIGCT
0.0027
−0.0014
0.0620
0.0067
0.0012
13232
|
|
LWQRPLVTI
QITLWQRPLVTIKIG
13233
|
|
VSLTETTNQ
QKVVSLTETTNQKTE
13234
|
|
VYLAWVPAH
KEKVYLAWVPAHKGI
13235
|
|
ICGHKAIGT
LIEICGHKAIGTVLV
13236
|
|
LRGTKALTE
CKLLRGTKALTEVIP
13237
|
|
LVNQIIEQL
ESELVNQIIEQLIKK
13238
|
|
LVSQIIEQL
ESELVSQIIEQLIKK
0.0059
0.0210
0.0095
0.0009
0.0040
13239
|
|
YFSVPLDKD
GDAYFSVPLDKDFRK
13240
|
|
IGRNMLTQI
VNIIGRNMLTQIGCT
13241
|
|
IKVRQLCKL
YPGIKVRQLCKLLRG
13242
|
|
LWKGPAKLL
RDPLWKGPAKLLWKG
13243
|
|
LWQRPLVTV
QITLWQRPLVTVKIG
13244
|
|
YAGIKVKQL
SQIYAGIKVKQLCKL
13245
|
|
IWGKTPKFK
SIVIWGKTPKFKLPI
13246
|
|
LREHLLKWG
IEELREIILLKWGFTT
13247
|
|
VQPIQLPEK
KWTVQPIQLPEKDSW
13248
|
|
WQRPLVTIK
ITLWQRPLVTIKIGG
13249
|
|
IIQAQPDRS
ALGIIQAQPDRSESE
13250
|
|
LQAIHLALQ
KTELQAIHLALQDSG
13251
|
|
LVEICTEME
IKALVEICTEMEKEG
13252
|
|
LRQHLLRWG
IEELRQHLLRWGFTT
13253
|
|
LTQLGCTLN
RNMLTQLGCTLNFPI
13254
|
|
LVSAGIRKV
VDKLVSAGIRKVLFL
0.0039
0.1500
−0.0026
0.0045
0.0120
13255
|
|
VDKLVSAGI
NEQVDKLVSAGIRKV
0.0024
0.5900
−0.0026
−0.0006
0.0028
13256
|
|
YPGIKVRQL
SQIYPGIKVRQLCKL
13257
|
|
FRKQNPDIV
LEPFRKQNPDIVIYQ
13258
|
|
FSFPQITLW
TVSFSFPQITLWQRP
13259
|
|
FTSTTVKAA
GSNFTSTTVKAACWW
13260
|
|
IIASDIQTK
IIDITASDIQTKELQ
13261
|
|
LAGRWPVKT
LLKLAGRWPVKTIHT
13262
|
|
VQKIATESI
TEAVQKIATESIVIW
13263
|
|
FTIPSTNNE
YTAFTIPSTNNETPG
13264
|
|
LEDINLPGK
DTVLEDINLPGKWKP
13265
|
|
LTDIVPLTE
AKALTDIVPLTEEAE
13266
|
|
LVTIKIGGQ
QRPLVTIKIGGQLKE
13261
|
|
MRGAHTNDV
YARMRGAHTNDVKQL
13268
|
|
VKTIHTDNG
RWPVKTIHTDNGSNF
13269
|
|
VQPIVLPEK
KWTVQPIVLPEKDSW
13270
|
|
WPVKTIHTD
AGRWPVKTIHTDNGS
13271
|
|
WQRPLVTVK
ITLWQRPLVTVKIGG
13272
|
|
WTVQPIVLP
PDKWTVQPIVLPEKD
13273
|
|
YTAFTIPST
FRKYTAPTIPSTNNE
13274
|
|
IDIIASDIQ
ERIIDIIASDIQTKE
13275
|
|
IIDIIASDI
GERIIDTIASDIQTK
13276
|
|
IVDIIATDI
GERIVDIIATDIQTK
0.0031
0.0320
0.0026
13277
|
|
LEEINLPGK
DTVLEEINLPGKWKP
13278
|
|
LQAIYLALQ
KTELQAIYLALQDSG
13279
|
|
LQKQTIKIQ
TKELQKQIIKIQNFR
13280
|
|
VDIIATDIQ
ERIVDIIATDIQTKE
13281
|
|
YDQIPIEIC
VRQYDQIPIEICGKK
13282
|
|
FNFPQITLW
VPTFNFPQITLWQRP
13283
|
|
IGRNMLTQL
VNIIGRNMLTQLGCT
13284
|
|
ISRIGPENP
EGKISRIGPENPYNT
13285
|
|
LTEVIPLTE
TKALTEVIPLTEEAE
13286
|
|
MESIVIWGK
KIAMESIVIWGKTPK
13287
|
|
VPRRKVKII
IKVVPRRKVKIIRPY
13288
|
|
VSFSPPQIT
QGTVSFSFPQITLWQ
13289
|
|
WYQLETEPI
VKLWYQLETEPIVGA
13290
|
|
YPGIKVKQL
SQIVPGIKVKQLCKL
13291
|
|
FPQGEAREF
NLAFPQGEAREFPPE
13292
|
|
LIEALLDTG
GGQLIEALLDTGADD
13293
|
|
VSLTDTTNQ
QKVVSLTDTTNQKTE
13294
|
|
WETWWTDYW
KETWETWWTDYWQAT
13295
|
|
YAKMRTAHT
TGKYAKMRTAHTNDV
13296
|
|
YKNLKTGKY
QEPYKNLKTGKYARM
13297
|
|
LQLPPLERL
PVPLQLPPLERLTLD
13298
|
|
VPLQLPPLE
AEPVPLQLPPLERLT
13299
|
|
LYQSNPPPS
IKFLYQSNPPPSPEG
13300
|
|
VRIIKILYQ
LKAVRIIKILYQSNP
13301
|
|
YQSNPPPSP
KFLYQSNPPPSPEGT
13302
|
|
LQLPPIERL
PVPLQLPPIERLRLD
13303
|
|
VPLQLPPIE
AEPVPLQLPPIERLR
13304
|
|
WNHPGSQPK
LEPWNHPGSQPKTAC
13305
|
|
FLNKGLGIS
QVCFLNKGLGISYGR
13306
|
|
WKHPGSQPK
LEPWKHPGSQPKTAC
13307
|
|
YCKKCCFHC
NNCYCKKCCFHCQVC
13308
|
|
YCKKCCYHC
TNCYCKKCCYHCQVC
13309
|
|
WNHPGSQPT
LEPWNIIPGSQPTTAC
13310
|
|
MIVWQVDRM
WQVMIVWQVDRMRIR
13311
|
|
WQVMIVWQV
ENRWQVMIVWQVDRM
3.3000
0.0059
0.0036
−0.0043
0.0690
1.9000
0.0032
−0.0045
0.0018
0.1200
0.1500
0.2900
13312
|
|
WQVDLMPIR
MIVWQVDRMRIRTWK
13313
|
|
LQYLALTAL
VGSLQYLALTALIKP
13314
|
|
LGHGVSIEW
DWHLGHGVSIEWRLR
13315
|
|
VDRMRIRTW
VWQVDRMRIRTWNSL
13316
|
|
YFDCFSESA
HLYYFDCFSESAIRN
13317
|
|
YWGLHTGER
ITTYWGLHTGERDWH
13318
|
|
IRTWNSLVK
RMRIRTWNSLVKHHM
13319
|
|
LGQGVSIEW
DWHLGQGVSIEWRKK
13320
|
|
LVKHHMYVS
WNSLVKHHMYVSKKA
13321
|
|
IPLGEARLV
EVHIPLGEARLVVRT
13322
|
|
LVKHHMYIS
WKSLVKHHMYISGKA
13323
|
|
YLALTALIK
SLQYLALTALIKPKK
13324
|
|
TRTWKSLVK
RMRIRTWKSLVKHIIM
13325
|
|
LADQLIHLY
DPDLADQLIHLYYFD
13326
|
|
LALTALIKP
LQYLALTALIKPKKI
13327
|
|
VDPGLADQL
STQVDPGLADQLIHL
13328
|
|
LYYFDCFSE
LIHLYYFDCFSESAI
13329
|
|
FSESAIRKA
FDCFSESAIRKAILG
13330
|
|
LADQLIHMH
EPGLADQLIHMHYPD
13331
|
|
WQVDRMKIR
LIVWQVDRMKIRTWN
13332
|
|
FSDSAIRKA
FDCFSDSAIRKAILG
13333
|
|
FSESAIRNA
FDCFSESAIRNAILG
13334
|
|
IVSPRCEYQ
LGHIVSPRCEYQAGH
13333
|
|
LQYLALAAL
VGSLQYLALAALITP
13336
|
|
VDRMKIRTW
VWQVDRMKIRTWNSL
13337
|
|
YWGLQTGER
IKTYWGLQTGERDWH
13338
|
|
IPLGDARLV
EVHIPLGDARLVITT
13339
|
|
LQYLALKAL
VGSLQYLALKALVTP
13340
|
|
WQVDRMRIN
MIVWQVDRMRINTWK
13341
|
|
IKPKKIKPP
TALIKPKKIKPPLPS
13342
|
|
VDRMRINTW
VWQVDRMRINTWKSL
13343
|
|
IGCQHSRIG
IIFRIGCQHSRIGITR
13344
|
|
WTLELLEEL
YNEWTLELLEELKSE
13345
|
|
ILQQLLFIH
IIRILQQLLFIHFRI
0.0054
0.0200
0.0084
13346
|
|
FIHFRIGCQ
QLLFIHFRIGCQHSR
13347
|
|
YNEWTLELL
REPYNEWTLELLEEL
13348
|
|
FPRPWLHGL
VRHFPRPWLNGLGQH
13349
|
|
WEGVEAIIR
GDTWEGVEAIIRTLQ
13350
|
|
LEELKSEAV
LELLEELKSEAVRHF
13551
|
|
WAGVEAIIR
GDTWAGVEAIIRILQ
13352
|
|
YGDTWAGVE
YETYGDTWAGVEAII
13353
|
|
IGCRHSRIG
HFRTGCRHSRIGITR
13354
|
|
FIHFRIGCR
QLLFIHFRIGCRHSR
13355
|
|
FVHFRIGCQ
QLLFVHFPIGCQHSR
13356
|
|
YGDTWTGVE
YETYGDTWTGVEAII
13351
|
|
FPRIWLHSL
VRHFPRIWLHSLGQII
13358
|
|
WALELLEEL
YNEWALELLEELKPIE
13359
|
|
LVTLLSSSK
EEWLVTLLSSSKLDQ
13360
|
|
VTLLSSSKL
EWLVTLLSSSKLDQG
13361
|
|
IIAIVVWTI
VVAIIAIVVWTIVFI
13362
|
|
VDYRIVIVA
LAKVDYRIVIVAFIV
13363
|
|
LRQRKIDRL
RKILRQRKIDRLIDR
13364
|
|
IVVWTIVFI
IIAIVVWTIVFIEYR
13365
|
|
VVWTIVFIE
IAIVVWTIVFIEYRK
13366
|
|
IEYRKILRQ
IVFTEYRKILRQRKI
13367
|
|
ILAIVALVV
SLYILAIVALVYAII
13368
|
|
WTIVFIEYR
IVVWTIVFIEYRKIL
13369
|
|
LAIVALVVA
LQILAIVALVVAGII
13370
|
|
TABLE XXa
|
|
|
HIV DR 3a Motif Peptides
|
Core
|
Core
Sequence
Exemplary
Exemplary
|
Core
Sequence
Conservancy
Sequence
Sequence
|
Protein
Sequence
Frequency
(%)
Exemplary Sequence
Position
Frequency
Conservancy (%)
SEQ ID NO.
|
|
ENV
VPTDPNPQE
53
83
HACVPTDPNPQEVVL
85
12
19
13371
|
|
ENV
YLKDQQLLG
31
48
VERYLKDQQLLGIWG
669
18
28
13372
|
|
ENV
MHEDIISLW
29
45
VEQMHEDIISLWDQS
114
17
27
13373
|
|
ENV
VSFEPIPIH
29
45
CPKVSFEPIPIHYCA
250
18
28
13374
|
|
ENV
LAVERYLKD
26
41
ARVLAVERYLKDQQL
664
15
23
13375
|
|
ENV
VKIEPLGVA
23
36
YKVVKIEPLGVAPTK
564
15
23
13376
|
|
ENV
VWKEATTTL
22
34
GVPVWKEATTTLFCA
52
22
34
13377
|
|
ENV
LAWDDLRSL
20
31
FLALAWDDLRSLCLF
849
19
30
13378
|
|
ENV
LIEESQNQQ
20
31
IYTLIEESQNQQEKN
737
07
11
13379
|
|
ENV
LGWEGLKYL
09
29
GLRLGWEGLKYLWNL
892
07
23
13380
|
|
ENV
LELDKWASL
18
28
QELLELDKWASLWNW
755
07
11
13381
|
|
ENV
YLRDQQLLG
18
28
VERYLRDQQLLGIWG
669
11
17
13382
|
|
ENV
MWQEVGKAM
15
23
IINMWQEVGKAMYAP
492
12
19
13383
|
|
ENV
IEEEGGERD
13
20
PEGIEEEGGERDRDR
827
08
13
13384
|
|
ENV
MNNENNGTN
01
20
INEMNNENNGThSTW
212
01
2
13385
|
|
ENV
IBEEGGEQD
12
19
LGRIEEEGGEQDKNR
827
02
3
13386
|
|
ENV
LAEEEVVIR
12
19
NGSLAEEEVVIRSEN
309
04
6
13387
|
|
ENV
LALDKWASL
11
17
QDLLALDKWASLWNW
753
05
8
13388
|
|
ENV
LAVERYLRD
11
17
ARVLAVERYLRDQQL
664
10
16
13389
|
|
ENV
IRShNLTNN
10
16
EIIIRSENLTNNVKT
317
03
5
13390
|
|
ENV
MEWEREIDN
10
16
MTWMEWEREIDNYTS
721
03
5
13391
|
|
GAG
INEEAAEWD
55
86
KETINEEAAEWDRLH
223
18
28
13392
|
|
GAG
FSPEVIPMF
54
84
EKAFSPEVIPMFSAL
182
36
56
13393
|
|
GAG
VLAEAMSQV
33
52
KARVLAEAMSQVTNS
383
09
14
13394
|
|
GAG
MLKDTINEE
32
50
AMQMLKDTINEEAAE
218
30
47
13395
|
|
GAG
VVEEKAFSP
28
44
WVKVVEEKAFSPEVI
176
28
44
13396
|
|
GAG
LRAEQATQE
27
42
FKTLRAEQATQEVKN
325
09
14
13397
|
|
GAG
MLKETINEE
23
36
AMQMLKETINEEAAE
218
22
34
13398
|
|
GAG
VTEEKAFSP
21
33
WVKVIEEKAFSPEVI
176
20
31
13399
|
|
GAG
VLAEAMSQA
16
25
KARVLAEAMSQASGA
383
03
5
13400
|
|
GAG
IEEEQNKSK
15
23
LDKIEEEQNKSKKKA
203
09
14
13401
|
|
GAG
LRAEQATQD
14
22
FKTLRAEQATQDVKN
325
10
16
13402
|
|
GAG
LRAEQASQE
12
19
YKTLRAEQASQEVKN
325
12
19
13403
|
|
NEF
YEPDWQNYT
36
56
TQGYFPDWQNYTPGP
195
33
52
13404
|
|
NEF
FLKEKGGLE
30
47
LSHFLKEKGGLEGLI
114
15
23
13405
|
|
NEF
FLKEKGGLD
26
41
LSFFLKEKGGLDGLI
114
14
22
13406
|
|
NEF
FFPDWQNYT
17
27
TQGFFPDWQNYTPGP
195
17
27
13407
|
|
NEF
VSRDLEKHG
11
17
VGAVSRDLEKHGAIT
46
11
17
13408
|
|
POL
YMDDLYVGS
62
97
IYQYMDDLYVGSDLE
369
59
92
13409
|
|
POL
IDPENPYNT
60
94
ISKIGPENPYNTPVF
236
28
44
13410
|
|
POL
LHPDKWTVQ
60
94
GYELHPDKWTVQPIQ
420
29
45
13411
|
|
POL
IVTDSQYAL
59
92
EVNIVTDSQYALGII
684
58
91
13412
|
|
POL
IPAETGQET
58
91
AEVIPAETGQETAYF
838
55
86
13413
|
|
POL
LTEEKIKAL
56
88
QWPLTEEKIKALTEI
210
26
41
13414
|
|
POL
IEAEVIPAE
55
86
SGYIEAEVIPAETGQ
833
51
80
13415
|
|
POL
LFLDGIDKA
55
86
RXVLFLDGIDKAQEE
749
32
50
13416
|
|
POL
VAKEIVASC
54
86
PPVVAKEIVASCDKC
781
22
34
13417
|
|
POL
LKGEAMHGQ
53
83
KCQLKGEAMHGQVDC
794
47
73
13418
|
|
POL
VGSDLEIGQ
53
83
DLYVGSDLEIGQHRA
375
28
44
13419
|
|
POL
IIRDYGKQM
50
78
KAKIIRDYGKQMAGD
1017
36
56
13420
|
|
POL
MASDFNLPP
41
73
WRAMASDFNLPPVVA
771
24
38
13421
|
|
POL
FYVDGAANR
43
61
AETFYVDGAANRETK
629
33
52
13422
|
|
POL
IHTDNGSNF
42
66
VKVIHTDNOSNFTSA
862
11
27
13423
|
|
POL
ILKEPVHGV
41
64
NREILKEPVHDVYYD
495
36
56
13424
|
|
POL
IYQEPFKNL
40
63
TYQIYQEPFKNLKTG
530
39
61
13425
|
|
POL
VYYDPSKDL
39
61
VHGVYYDPSKDLIAE
506
26
41
13426
|
|
POL
YVTDRGRQK
39
61
KAGYVTDRGRQKVVS
646
19
30
13427
|
|
POL
LTEEAELEL
37
58
IVPLTEEAELELAEN
481
12
19
13428
|
|
POL
V1QDNSDIK
37
58
GAVVIQDNSDIKVVP
999
37
58
13429
|
|
POL
IATDIQTKE
35
55
IDIIATDIQTKELQK
953
22
34
13430
|
|
POL
INNETPGIR
32
51
IPSINNETPGIRYQY
321
31
48
13431
|
|
POL
LIAEIQKQG
30
47
SKDLIAEIQKQGQGQ
514
09
14
13432
|
|
POL
ICTEMEKEG
28
44
LVEICTEMEKEGKIS
221
14
22
13433
|
|
POL
VGAETFYVD
28
44
EPIVGAETFYVDGAA
624
20
31
13434
|
|
POL
TQKETWETW
27
42
RLPIQKETWETWWTD
582
09
14
13435
|
|
POL
IKQEFGIPY
26
41
WAGIKQEFGIPYNPQ
884
21
33
13436
|
|
POL
MAGDDCVAG
25
39
GKQMAGDDCVAGRQD
1025
23
36
13437
|
|
POL
IKKEKVYLA
20
31
EQLIKKEKVYLAWVP
115
19
30
13438
|
|
POL
MAGDDCVAS
19
30
GKQMAGDDCVASRQD
1025
19
30
13439
|
|
POL
VPLDKDFRK
18
28
YFSVPLDKDFRKYTA
304
18
29
13440
|
|
POL
IQQEFGIPY
16
25
WAGIQQEFGIPYNPQ
884
11
11
13441
|
|
POL
LEKEPIVGA
16
25
WYQLEKEPIVGAETF
618
16
25
13442
|
|
POL
YQLEKEPIV
16
25
KLWYQLEKEPIVGAE
616
16
25
13443
|
|
POL
IQKETWEAW
15
23
KLPIQKETWEAWWTE
582
05
8
13444
|
|
POL
PSSEQTRAN
14
22
AREFSSEQTRANSPT
14
10
16
13445
|
|
POL
IASDIQTKE
14
22
IDIIASDIQTKELQK
953
09
14
13446
|
|
POL
IATESIVIW
14
22
VQKIATESIVIWGKT
564
11
17
13447
|
|
POL
ILIEICGKK
14
22
YDQILIEICGKKAIG
146
13
20
13448
|
|
POL
VLEEINLPD
14
22
DDTVLEEINLPGKWK
116
11
11
13449
|
|
POL
IKKEKVYLS
13
20
EQLIKKEKVYLSWVP
715
07
11
13450
|
|
POL
VLEDINLPG
13
20
DDTVLEDINLPGKWK
116
13
20
13451
|
|
POL
VLPEKDSWT
13
20
QPIVLPEKDSWTVND
431
13
20
13452
|
|
POL
VIQONSEYK
12
19
GAVVIQDNSEIKVVP
999
12
19
13453
|
|
POL
IIKDYGKQM
11
17
KAKIIKDYGKQMAGA
1017
06
9
13454
|
|
TAT
VERETETDP
11
17
KEKVERETETDPAVQ
95
01
2
13455
|
|
VIF
LTEDRWNKP
28
44
VKKLTEDRWNKPQKT
175
09
14
13456
|
|
VIF
YYFDCFSES
20
31
IHLYYFDCPSESAIR
112
14
22
13457
|
|
VIF
LVEDRWNKP
11
17
VQKLVEDRWNKPQKT
175
04
6
13458
|
|
VIF
IDPDLADQL
10
16
STQIDPDLADQLIHL
100
10
16
13459
|
|
VPR
LKNEAVRHF
18
28
LEELKNEAVRHFPRP
23
10
16
13460
|
|
VPR
LKSEAVRHF
15
23
LEELKSEAVRHFPRI
23
07
11
13461
|
|
VPR
YIYETYGDT
14
22
LGQYIYETYGDTWAG
42
07
11
13462
|
|
VPR
LKQEAVRHF
11
17
LEELKQEAVRHFPRP
23
06
9
13463
|
|
TABLE XXb
|
|
|
HIV DR 3a Motif Peptides with Binding Information
|
|
|
Core Sequence
Exemplary Sequence
DR1
DR2wβ1
DR2w2β2
DR3
DR4w4
DR4w15
DR5w11
DR5w12
SEQ ID NO.
|
|
VPTDPNPQE
HACVPTDPNPQEVVL
13371
|
|
YLKDQQLLG
VERYLKDQQLLGIWG
13372
|
|
MHEDIISLW
VEQMHEDIISLWDQS
13373
|
|
VSFEPIPIH
CPKVSFEPIPIHYCA
13374
|
|
LAVERYLKD
ARVLAVERYLKDQQL
13375
|
|
VKIEPLGVA
YKVVKIEPLGVAPTK
13376
|
|
VWKEATTTL
GVPVWKEATTTLFCA
13377
|
|
LAWDDLRSL
FLALAWDDLRSLCLF
13378
|
|
LIBESQNQQ
IYTLIEESQNQQEKN
13379
|
|
LGWEGLKYL
GLRLGWEGLKYLWNL
13380
|
|
LELDKWASL
QELLELDKWASLWNW
13381
|
|
YLRDQQLLG
VERYLRDQQLLGIWG
13382
|
|
MWQEVGKAM
IINMWQEVGKAMYAP
13383
|
|
IBEEGGERD
PEGIEEEGGERDRDR
13384
|
|
MNNENNGTN
TNEMNNENNGTNSTW
13385
|
|
IEEEGGEQD
LGRIEEEGGEQDKNR
13386
|
|
LAEEEVVIR
NGSLAEEEVVIRSEN
13387
|
|
LALDKWASL
QDLLALDKWASLWNW
13388
|
|
LAVERYLRD
ARVLAVERYLRDQQL
13389
|
|
LRSENLTNN
EIIIRSENLTNNVKT
13390
|
|
MEWERETDN
MTWMEWEREIDNYTS
13391
|
|
TNEEAAEWD
KETTNEEAAEWDRLH
13392
|
|
FSPEVIPMF
EKAFSPEVIPMFSAL
0.0086
0.0015
−0.0130
0.0340
−0.0010
13393
|
|
VLAEAMSQV
KARVLAEAMSQVTNS
0.0080
0.0120
13394
|
|
MLKDTINEE
AMQMLKDTTNEEAAE
13395
|
|
VVEEKAFSP
WVKVVEEKAFSPEVI
0.0006
0.0016
13396
|
|
LRAEQATQE
PKTLRAEQATQEVKN
13397
|
|
MLKETTNEE
AMQMLKETINEEAAE
13398
|
|
VIEEKAFSP
WVKVIEEKAFSPEVI
13399
|
|
VLAEAMSQA
KARVLAEAMSQASGA
13400
|
|
IEEEQNKSK
LDKIEEEQNKSKKKA
13401
|
|
LRAEQATQD
FKTLRAEQATQDVKN
13402
|
|
LRAEQASQE
YKTLRAEQASQEVKN
13403
|
|
YFPDWQNYT
TQGYFPDWQNYTPGP
−0.00 17
13404
|
|
FLKEKGGLE
LSHFLKEKGGLEGLI
13405
|
|
FLKEKGGLD
LSFFLKEKGGLDGLI
13406
|
|
FFPDWQNYT
TQGFFPDWQNYTPGP
13407
|
|
VSRDLEKHG
VGAVSRDLEKIHAIT
13408
|
|
YMDDLYVGS
IYQYMDDLYVGSDLE
13409
|
|
IDPENPYNT
ISKIGPENPYNTPVF
0.0001
−0.0014
−0.0130
0.0026
−0.0006
13410
|
|
LHPDKWTVQ
GYELHPDKWTVQPIQ
13411
|
|
IVTDSQYAL
EVNIVTDSQYALGII
0.0002
0.0034
−0.0010
0.4100
−0.0055
0.0006
13412
|
|
IPAETGQET
AEVIPAETGQETAYF
0.0033
13413
|
|
LTEEKIKAL
QWPLTEEKIKALTEI
13414
|
|
IEAEVIPAE
SGYIEAEVIPAETGQ
13415
|
|
LFLDGIDKA
RKVLFLDGIDKAQEE
13416
|
|
VAKEIVASC
PPVVAKEIVASCDKC
0.0001
−0.0021
−0.0130
0.0085
0.0006
13417
|
|
LKGEAMHGQ
KCQLKOEAMHGQVDC
−0.0017
13418
|
|
VGSDLEIGQ
DLYVGSDLEIGQHRA
13419
|
|
IIRDYGKQM
KAKIIRDYGKQMAGD
13420
|
|
MASDFNLPP
WRAMASDFNLPPVVA
13421
|
|
FYVDGAANR
AETFYVDGAANRETK
0.0021
−0.0005
0.0046
0.3900
0.0150
−0.0006
13422
|
|
IITDNGSNF
VKVIHTDNGSNFTSA
13423
|
|
ILKEPVHGV
NREILKEPVHGVYYD
0.3000
0.1500
−0.0014
0.1000
0.1900
0.0300
−0.0007
0.0230
13424
|
|
IYQEPFKNL
TYQIYQEPFKNLKTG
−0.0017
13425
|
|
VYYDPSKDL
VHGVYYDPSKDLLAE
13426
|
|
YVTDRGRQK
KAUYVTDRGRQKVVS
13427
|
|
LTEEAELEL
IVPLTEEAELELAEN
13428
|
|
VIQGNSDIK
GAVVIQDNSDIKVVP
0.0033
0.0280
0.0014
0.3000
−0.0055
−0.0006
13429
|
|
IATDIQTKE
IDHATDIQTKELQK
13430
|
|
INNETPGIR
IPSINNETPGIRYQY
13431
|
|
LIAEIQKQG
SKDLIAEIQKQGQGQ
13432
|
|
ICTEMEKEG
LVEICTEMEKECKIS
−0.0017
13433
|
|
VGAETFYVD
EPIVGAETFYVDGAA
13434
|
|
IQKETWETW
RLPIQKETWETWWTD
13435
|
|
IKQEFGIPY
WAGIKQEFGIPYNPQ
0.0018
0.0018
0.1600
1.0000
0.0140
−0.0006
13436
|
|
MAGDDCVAG
GKQMAGDDCVAGRQD
13437
|
|
IKKEKVYLA
EQLIKKEKVYLAWVP
0.6400
0.0800
0.0059
0.0300
4.1000
0.0058
−0.0045
13438
|
|
MAGDDCVAS
GKQMAGDDCVASRQD
13439
|
|
VPLDKDFRK
YFSVPLDKDFRKYTA
13440
|
|
IQQEFGIPY
WAGIQQEFGIPYNPQ
13441
|
|
LEKEPIVGA
WYQLEKEPIVGAETF
13442
|
|
YQLEKEPIV
KLWYQLEKEPIVGAE
13443
|
|
IQKETWEAW
KLPIQKETWEAWWTE
13444
|
|
FSSEQTRAN
AREFSSEQTRANSPT
13445
|
|
IASDIQTKE
IDILASDIQTKELQK
13446
|
|
IATESIVIW
VQKIATESIVIWGKT
13447
|
|
ILIEICGKK
YDQILIEICGKKAIG
13448
|
|
VLEEINLPG
DDTVLEEINLPGKWK
13449
|
|
IKKCKVYLS
EQLIKKEKVYLSWVP
13450
|
|
VLEDINLPG
DDTVLEDINLPGKWK
13451
|
|
VLPEKDSWT
QPIVLPEKDSWTVND
13452
|
|
VIQDNSEIK
GAVVLQDNSEIKVVP
13453
|
|
IIKDYGKQM
KAKIIKDYGKQMAOA
13454
|
|
VERETETDP
KEKVERETETDPAVQ
13455
|
|
LTEDRWNKP
VKKLTEDRWNKPQKT
13456
|
|
YYFDCFSES
IHLYYFDCFSESAIR
13457
|
|
LVEDRWNKP
VQKLVEDRWNKPQKT
13458
|
|
IDPDLADQL
STQIDPDLADQLIHL
13459
|
|
LKNEAVRHF
LEELKNEAVRHFPRP
13460
|
|
LKSEAVRHF
LEELKSEAVRHFPRI
13461
|
|
YIYETYGDT
LGQYIYETYGDTWAG
13462
|
|
LKQEAVRHF
LEELKQEAVRIWPRP
13463
|
|
Core Sequence
DR6w19
DR7
DR8w2
DR9
DRw53
SEQ ID NO.
|
|
VPTDPNPQE
13371
|
|
YLKDQQLLG
13372
|
|
MHEDIISLW
13373
|
|
VSFEPIPIH
13374
|
|
LAVERYLKD
13375
|
|
VKIEPLGVA
13376
|
|
VWKEATTTL
13377
|
|
LAWDDLRSL
13378
|
|
LIBESQNQQ
13379
|
|
LGWEGLKYL
13380
|
|
LELDKWASL
13381
|
|
YLRDQQLLG
13382
|
|
MWQEVGKAM
13383
|
|
IBEEGGERD
13384
|
|
MNNENNGTN
13385
|
|
IEEEGGEQD
13386
|
|
LAEEEVVIR
13387
|
|
LALDKWASL
13388
|
|
LAVERYLRD
13389
|
|
LRSENLTNN
13390
|
|
MEWERETDN
13391
|
|
TNEEAAEWD
13392
|
|
FSPEVIPMF
0.0023
13393
|
|
VLAEAMSQV
0.0025
13394
|
|
MLKDTINEE
13395
|
|
VVEEKAFSP
0.0003
13396
|
|
LRAEQATQE
13397
|
|
MLKETTNEE
13398
|
|
VIEEKAFSP
13399
|
|
VLAEAMSQA
13400
|
|
IEEEQNKSK
13401
|
|
LRAEQATQD
13402
|
|
LRAEQASQE
13403
|
|
YFPDWQNYT
13404
|
|
FLKEKGGLE
13405
|
|
FLKEKGGLD
13406
|
|
FFPDWQNYT
13407
|
|
VSRDLEKHG
13408
|
|
YMDDLYVGS
13409
|
|
IDPENPYNT
−0.0005
13410
|
|
LHPDKWTVQ
13411
|
|
IVTDSQYAL
0.0108
−0.0014
−0.0009
13412
|
|
IPAETGQET
13413
|
|
LTEEKIKAL
13414
|
|
IEAEVIPAE
13415
|
|
LFLDGIDKA
13416
|
|
VAKEIVASC
0.0015
13417
|
|
LKGEAMHGQ
13418
|
|
VGSDLEIGQ
13419
|
|
IIRDYGKQM
13420
|
|
MASDFNLPP
13421
|
|
FYVDGAANR
−0.0002
−0.0014
0.0035
13422
|
|
IITDNGSNF
13423
|
|
ILKEPVHGV
0.0120
0.0033
0.0010
0.0210
13424
|
|
IYQEPFKNL
13425
|
|
VYYDPSKDL
13426
|
|
YVTDRGRQK
13427
|
|
LTEEAELEL
13428
|
|
VIQGNSDIK
0.0447
−0.0014
−0.0009
13429
|
|
IATDIQTKE
13430
|
|
INNETPGIR
13431
|
|
LIAEIQKQG
13432
|
|
ICTEMEKEG
13433
|
|
VGAETFYVD
13434
|
|
IQKETWETW
13435
|
|
IKQEFGIPY
0.0123
−0.0014
−0.0009
13436
|
|
MAGDDCVAG
13437
|
|
IKKEKVYLA
−0.0003
−0.0005
−0.0015
0.0011
13438
|
|
MAGDDCVAS
13439
|
|
VPLDKDFRK
13440
|
|
IQQEFGIPY
13441
|
|
LEKEPIVGA
13442
|
|
YQLEKEPIV
13443
|
|
IQKETWEAW
13444
|
|
FSSEQTRAN
13445
|
|
IASDIQTKE
13446
|
|
IATESIVIW
13447
|
|
ILIEICGKK
13448
|
|
VLEEINLPG
13449
|
|
IKKCKVYLS
13450
|
|
VLEDINLPG
13451
|
|
VLPEKDSWT
13452
|
|
VIQDNSEIK
13453
|
|
IIKDYGKQM
13454
|
|
VERETETDP
13455
|
|
LTEDRWNKP
13456
|
|
YYFDCFSES
13457
|
|
LVEDRWNKP
13458
|
|
IDPDLADQL
13459
|
|
LKNEAVRHF
13460
|
|
LKSEAVRHF
13461
|
|
YIYETYGDT
13462
|
|
LKQEAVRHF
13463
|
|
TABLE XXc
|
|
|
HIV DR 3b Motif Peptides
|
Core
|
Core
Sequence
Exemplary
Exemplary
|
Core
Sequence
Conservancy
Sequence
Sequence
|
Protein
Sequence
Frequency
(%)
Exemplary Sequence
Position
Frequency
Conservancy (%)
SEQ ID NO.
|
|
ENV
MRDNWRSEL
40
63
GGDMRDNWRSELYKY
550
37
38
13464
|
|
ENV
LTVQARQLL
36
56
SITLTVQARQLLSGI
620
27
42
13465
|
|
ENV
IEAQQHLLQ
35
55
LRAIEAQQHLLQLTV
642
34
53
33466
|
|
ENV
IIGDIRQAH
27
44
TGEIIGDIRQAHCNI
370
07
11
13467
|
|
ENV
VEREKRAVG
23
37
RRVVEREKRAVGIGA
582
11
17
13468
|
|
ENV
MVEQMHEDI
23
36
KNNMVEQMHEDIISL
130
39
30
13469
|
|
ENV
AWDDLRSLC
20
31
LALAWDDLRSLCLFS
830
38
28
13470
|
|
ENV
LEITTHSFN
20
33
GGDLEITIHSFNCRG
426
30
16
13471
|
|
ENV
YDTEVHNVW
18
28
AKAYDTEVHNVWATh
71
15
23
13472
|
|
ENV
AEGTDRIIE
17
27
IAVAEGTDRIIEVVQ
927
02
3
13473
|
|
ENV
VQREKRAVG
37
27
RRVVQREKRAVGIGA
582
05
8
13474
|
|
ENV
AEGTDRVIE
15
23
IAVAEGTDRVIEVVQ
927
07
11
13475
|
|
ENV
IEAQQHLLK
32
39
LRAIEAQQHLLKLTV
642
08
13
13476
|
|
ENV
LKCNDKKFN
32
19
FAILKCNDKKFNGTG
269
05
8
13477
|
|
GAG
ANPDCKTIL
45
70
VQNANPDCKTILKAL
347
27
42
13478
|
|
GAG
FYKTLRAEQ
28
44
VDRFYKTLRAEQASQ
321
39
30
13479
|
|
GAG
APGQMREPR
27
42
GPIAPGQMREPRGSD
242
39
30
13480
|
|
GAG
FFKTLRAEQ
27
42
VDRFFKTLRAEQATQ
323
26
41
13481
|
|
GAG
IWPSHKGPP
23
36
LGKIWPSHKGRPGNP
470
22
34
13482
|
|
GAG
LARNCRAPR
20
32
EGHLARNCRAPRKKG
431
39
30
13483
|
|
GAG
IAKNCRAPR
18
29
EGHIAKNCRAPRKKG
431
30
16
13484
|
|
GAG
ATQEVKNWM
18
28
AEQATQEVKNWMTET
330
34
22
13485
|
|
GAG
ATQDVKNWM
15
23
AEQATQDVKNWMTDT
330
11
37
13486
|
|
GAG
IARNCRAPR
33
21
EGHIARNCRAPRKKG
431
33
20
13487
|
|
GAG
LWPSNKGRP
13
20
LGKIWPSNKGRPGNF
470
33
20
13488
|
|
GAG
ANPDCKSIL
33
37
VQNANPDCKSILRAL
347
06
9
13489
|
|
GAG
ASQEVKNWM
33
17
AEQASQEVKNWMTET
330
11
37
13490
|
|
GAG
IWPSSKGRP
10
36
LGKIWPSSKGRPGNF
470
30
36
13493
|
|
NEF
LIYSKKRQE
15
28
LDGLIYSKKRQEILD
171
11
37
13492
|
|
NEF
VPVDPREVE
11
17
FKLVPVDPRBVEEAN
227
06
9
13493
|
|
NEF
MARELHPEY
30
16
FHHMARELHPEYYKD
316
04
6
13494
|
|
POL
MGYELHPDK
60
94
FLWMGYELHPDKWTV
416
60
94
13495
|
|
POL
FIHNFKRKG
58
91
MAVFIHNFKRKGGIG
930
57
89
13496
|
|
POL
MNKELKKII
56
89
VESMNKELKKIIGQV
903
45
70
13497
|
|
POL
IIGQVRDQA
44
69
LKKIIGQVRDQAEHL
910
43
67
13498
|
|
POL
YHSNWRAMA
39
61
HEKYHSNWRAMASDF
764
23
36
13499
|
|
POL
MEKEGKISK
36
56
CTEMEKEGKISKIGP
225
22
34
13500
|
|
POL
YYRDSRDPI
34
53
FRVYYRDSRDPLWKG
975
34
54
13503
|
|
POL
ANRETKLGK
30
47
DGAANRETKLGKAGY
635
28
44
13502
|
|
POL
IGGQLKEAL
25
39
TIKIGGQLKEALLDT
99
17
27
13503
|
|
POL
LDKDFRKYT
39
30
SVPLDKDFRKYTAFT
306
37
27
13504
|
|
POL
YYRDSRDPL
34
22
FRVYYRDSRDPLWKG
975
13
23
13505
|
|
POL
IIGQVREQA
33
20
LKKIIGQVREQAEHL
910
33
20
13506
|
|
POL
YHNNWRAMA
10
36
HEKYHNNWRAMASDF
764
06
9
13507
|
|
REV
ARRNRRRRW
39
61
TRQARRNRRRRWRAR
38
18
28
13508
|
|
REV
ARKNFRRRW
38
28
TRQARKNRRRRWRAR
38
13
20
13509
|
|
REV
LLKTVRLIK
30
16
DEELLKTVRLIKFLY
9
04
6
13530
|
|
VIF
ISSEVHIPL
27
42
HPRISSEVHIPLGDA
48
08
33
13533
|
|
VIF
VSSEVHIPL
27
42
HPKVSSEVHIPLGEA
48
33
17
13512
|
|
VIF
VSIEWRLRR
13
37
GHGVSIEWRLRRYST
85
05
8
13513
|
|
VPR
LPSNTRGRG
01
50
IGILPSNTRGRGRRN
82
01
2
13514
|
|
VPR
LLEELKNEA
17
27
TLELLEELKNEAVRH
19
12
19
13515
|
|
VPR
LLEELKSEA
16
25
TLELLEELKSEAVRH
19
15
23
13516
|
|
VPU
AKYDYRIVI
01
33
DLLAKVDYRIVIVAF
3
01
2
13517
|
|
VPU
AKVDYRLGV
01
33
NFLAKVDYRLGVCAL
3
01
2
13518
|
|
VPU
ILRQRKIDR
15
23
YRKILRQRKIDRLID
42
12
19
13519
|
|
TABLE XXd
|
|
|
HIV DR 3b Motif Peptides with Binding Information
|
|
|
Core Sequence
Exemplary Sequence
DR1
DR2wβ1
DR2w2β2
DR3
DR4w4
DR4w15
DR5w11
DR5w12
SEQ ID NO.
|
|
MRDNWRSEL
GGDMRDNWRSELYKY
13464
|
|
LTVQARQLL
SITLTVQARQLLSGI
13465
|
|
IEAQQHLLQ
LRAIEAQQHLLQLTV
13466
|
|
IIGDIRQAH
TGEIIGDIRQAHCNI
13467
|
|
VEREKRAVG
RRVVEREKRAVGIGA
13468
|
|
MVEQMHEDI
KNNMVEQMHEDIISL
13469
|
|
AWDDLRSLC
LALAWDDLRSLCLFS
13470
|
|
LEITTHSFN
GGDLEITTHSFNCRG
13471
|
|
YDTEVHNVW
AKAYDTEVHNVWATH
13472
|
|
AEGTDRIIE
IAVAEGTDRIIEVVQ
13473
|
|
VQREKRAVG
RRVVQREKRAVGIGA
13474
|
|
AEOTDRVTE
IAVAEGTDRVIEVVQ
13475
|
|
IEAQQHLLK
LRAIEAQQHLLKLTV
13476
|
|
LKCNDKKFN
FAILKCNDKKFNGTG
13477
|
|
ANPDCKTIL
VQNANPDCKTILKAL
0.0031
13478
|
|
FYKTLRAEQ
VDRFYKTLRAEQASQ
0.0049
13479
|
|
APOQMREPR
GPIAPGQMREPRGSD
−0.0017
13480
|
|
FFKTLRAEQ
VDRFFKTLRAEQATQ
13481
|
|
TWPSHKGRP
LOKIWPSHKGRPGNF
13482
|
|
LARNCRAPR
EGHLARNCRAPRKKG
13483
|
|
IAKNCRAPR
EGHIAKNCRAPRKKG
13484
|
|
ATQEVKNWM
AEQATQEVKNWMTET
13485
|
|
ATQDVKNWM
AEQATQDVKNWMTDT
13486
|
|
IARNCRAPR
EGHIARNCRAPRKKG
13487
|
|
IWPSNKGRP
LGKIWPSNKGRPGNF
13488
|
|
ANPDCKSIL
VQNANPDCKSILRAL
13489
|
|
ASQEVKNWM
AEQASQEVKNWMTET
13490
|
|
IWPSSKGRP
LGKIWPSSKGRPGNF
13491
|
|
LIYSKKRQE
LDGLIYSKKRQEILD
13492
|
|
VPVDPREVE
FKLVPVDPRIWEEAN
13493
|
|
MARELHPEY
FHHMARELHPEYYKD
13494
|
|
MGYELHPDK
FLWMGYELHPDKWTV
−0.0017
13495
|
|
FIHNFKRKG
MAVFIHNFKRKGGIG
0.0009
1.3000
0.0470
0.0085
6.9000
13496
|
|
MNKELKKII
VESMNKELKKIIGQV
13497
|
|
IIGQVRDQA
LKKIIGQVRDQAEHL
0.0700
13498
|
|
YHSNWRAMA
HEKYHSNWRAMASDF
0.0022
13499
|
|
MEKEGKISK
CTEMEKBGKISKIGP
0.0110
13500
|
|
YYRDSRDPI
FRVYYRDSRDPIWKG
13501
|
|
ANRETKLGK
DGAANRETKLCKAGY
−0.0017
13502
|
|
IGGQLKEAL
TIKIGGQLKEALLDT
0.0090
13503
|
|
LDKDFRKYT
SVPLDKGERKYTAFT
13504
|
|
YYRDSRDPL
FRVYYRDSRDPLWKG
13505
|
|
IIGQVREQA
LKKIIGQVREQAEHL
13506
|
|
YHNNWRAMA
HEKYHNNWRAMASDF
13507
|
|
ARRNRRRRW
TRQARRNRRRRWRAR
13508
|
|
ARKNRRRRW
TRQARKNRRRRWRAR
13509
|
|
LLKTVRLIK
DEELLKTVRLIKFLV
13510
|
|
ISSEVHIPL
HPRISSEVHIPLGDA
13511
|
|
VSSEVHIPL
HPKVSSEVHIPLGEA
13512
|
|
VSIEWRLRR
GHGVSIEWRLRRYST
13513
|
|
LPSNTRGRG
IGILPSNTRGRGRRN
13514
|
|
LLEELKNEA
TLELLEELKNEAVRH
13515
|
|
LLEELKSEA
TLELLEELKSEAVRH
13516
|
|
AKVDYRIVI
DLLAKVDYRIVIVAF
13517
|
|
AKVDYRLGV
NFLAKVDYRLGVGAL
13518
|
|
ILRQRKTDR
YRKILRQRKIDRLID
0.0024
0.0740
0.0410
13.0000
−0.0055
0.1500
13519
|
|
Core Sequence
DRw619
DR7
DR8w2
DR9
DRw53
SEQ ID NO.
|
|
MRDNWRSEL
13464
|
|
LTVQARQLL
13465
|
|
IEAQQHLLQ
13466
|
|
IIGDIRQAH
13467
|
|
VEREKRAVG
13468
|
|
MVEQMHEDI
13469
|
|
AWDDLRSLC
13470
|
|
LEITTHSFN
13471
|
|
YDTEVHNVW
13472
|
|
AEGTDRIIE
13473
|
|
VQREKRAVG
13474
|
|
AEOTDRVTE
13475
|
|
IEAQQHLLK
13476
|
|
LKCNDKKFN
13477
|
|
ANPDCKTIL
13478
|
|
FYKTLRAEQ
13479
|
|
APOQMREPR
13480
|
|
FFKTLRAEQ
13481
|
|
TWPSHKGRP
13482
|
|
LARNCRAPR
13483
|
|
IAKNCRAPR
13484
|
|
ATQEVKNWM
13485
|
|
ATQDVKNWM
13486
|
|
IARNCRAPR
13487
|
|
IWPSNKGRP
13488
|
|
ANPDCKSIL
13489
|
|
ASQEVKNWM
13490
|
|
IWPSSKGRP
13491
|
|
LIYSKKRQE
13492
|
|
VPVDPREVE
13493
|
|
MARELHPEY
13494
|
|
MGYELHPDK
13495
|
|
FIHNFKRKG
0.0048
13496
|
|
MNKELKKII
13497
|
|
IIGQVRDQA
13498
|
|
YHSNWRAMA
13499
|
|
MEKEGKISK
13500
|
|
YYRDSRDPI
13501
|
|
ANRETKLGK
13502
|
|
IGGQLKEAL
13503
|
|
LDKDFRKYT
13504
|
|
YYRDSRDPL
13505
|
|
IIGQVREQA
13506
|
|
YHNNWRAMA
13507
|
|
ARRNRRRRW
13508
|
|
ARKNRRRRW
13509
|
|
LLKTVRLIK
13510
|
|
ISSEVHIPL
13511
|
|
VSSEVHIPL
13512
|
|
VSIEWRLRR
13513
|
|
LPSNTRGRG
13514
|
|
LLEELKNEA
13515
|
|
LLEELKSEA
13516
|
|
AKVDYRIVI
13517
|
|
AKVDYRLGV
13518
|
|
ILRQRKTDR
0.0016
−0.0014
0.0270
13519
|
|
TABLE XXI
|
|
|
Population coverage with combined HLA Supertypes
|
PHENOTYPIC FREQUENCY
|
North
|
American
|
HLA-SUPERTYPES
Caucasian
Black
Japanese
Chinese
Hispanic
Average
|
|
a. Individual Supertypes
|
A2
45.8
39.0
42.4
45.9
43.0
43.2
|
A3
37.5
42.1
45.8
52.7
43.1
44.2
|
B7
38.6
52.7
48.8
35.5
47.1
44.7
|
A1
47.1
16.1
21.8
14.7
26.3
25.2
|
A24
23.9
38.9
58.6
40.1
38.3
40.0
|
B44
43.0
21.2
42.9
39.1
39.0
37.0
|
B27
28.4
26.1
13.3
13.9
35.3
23.4
|
B62
12.6
4.8
36.5
25.4
11.1
18.1
|
B58
10.0
25.1
1.6
9.0
5.9
10.3
|
b. Combined Supertypes
|
A2, A3, B7
83.0
86.1
87.5
88.4
86.3
86.2
|
A2, A3, B7, A24, B44, A1
99.5
98.1
100.0
99.5
99.4
99.3
|
A2, A3, B7, A24, B44, A1,
99.9
99.6
100.0
99.8
99.9
99.8
|
B27, B62, B58
|
|
TABLE XXIII
|
|
|
Immunogenicity of HIV peptides
|
Immunogenicity
|
Peptide
Seq ID
Sequence
Protein
patients
transgenic
|
|
A2 Supermotif
1261.04
14176
LTFGWCFKL
HIV nef 221
4/12
3/3
|
1261.15
14177
MASDFNLPPV
hiv pol 774
1/15
2/6
|
1069.32
14178
VLAEAMSQV
hiv gag 386
6/19
3/3
|
1261.16
14179
CTLNFPISPI
hiv pol 182
0/1
1/6
|
1261.02
14180
LLQLTVWGJ
HIV env 65l
2/8
1/6
|
1261.13
14181
KLVGKLNWA
HIV pol 448
3/15
3/3
|
1211.04
14182
KLTPLCVTL
HIV env 134
2/12
2/6
|
1261.08
14183
ALVEICTEM
HIV pol 220
0/2
1/6
|
1261.11
14184
AIIRILQQL
HIV vpr 59
5/9
0/6
|
1261.09
14185
LVGPTPVNI
HIV pol 163
1/9
1/6
|
1261.12
14186
RILQQLLFI
HIV vpr 62
6/20
2/6
|
1261.05
14187
TLNFPISPI
HIV pol 183
1/7
0/6
|
1261.03
14188
MTNNPPIPV
HIV gag 271
2/17
4/6
|
1261.17
14189
KMIGGIGGFI
HIV pol 132
2/7
0/6
|
941.03
14190
ILKEPVHGV
HIV pol 498
8/19
3/6
|
1261.10
14191
RAMASDFNL
HIV pol 772
2/9
0/6
|
1261.07
14192
KAACWWAGI
HIV pol 879
1/8
0/6
|
|
|
|
DR Supermotif
27
14204
KRWILGLNKIVRMY
HIV gag 298
3/13
|
27
14205
GEIYKRWILGLNKI
HIV gag 294
2/13
|
27
14206
WEFVNTPPLVKLWYQ
HIV pol 596
2/13
|
27
14207
QKQITKIQNFRVYYR
HIV pol 956
3/13
|
1280
14208
KVYLAWVPAHKGIGG
HIV pol 712
3/13
|
27
14209
EKVYLAWVPAHKGIG
HIV pol 711
1/13
|
27
14210
QGQMVHQAISPRTLN
HIV gag 171
4/13
|
27
14211
SPAIFQSSMTKILEP
HIV pol 335
3/13
|
27
14212
FRKYTAFTIPSINNE
HIV pol 303
3/13
|
27
14213
HSNWRAMASDFNLPP
HIV pol 758
3/13
|
27
14214
KTAVQMAVFIHNFKR
HIV pol 915
4/13
|
|
TABLE XXIV
|
|
|
MIIC-peptide binding assays: cell lines and radiolabeled ligands.
|
Radiolabeled peptide
|
Species
Antigen
Allele
Cell line
Source
Seq ID
Sequence
|
|
A. Class I binding assays
|
Human
A1
A*0101
Steinlin
Hu. J chain 102—110
14215
YTAVVPLVY
|
A2
A*0201
JY
HBVc 18—27 F6 -> Y
14216
FLPSDYFPSV
|
A2
A*0202
P815 (transfected)
HBVc 18—27 F6 -> Y
14217
FLPSDYFPSV
|
A2
A*0203
FUN
HBVc 18—27 F6 -> Y
14218
FLPSDYFPSV
|
A2
A*0206
CLA
HBVc 18—27 F6 -> Y
14219
FLPSDYFPSV
|
A2
A*0207
721.221 (transfected)
HBVc 18—27 F6 -> Y
14220
FLPSDYFPSV
|
A3
GM3107
non-natural (A3CON1)
14221
KVFPYALINK
|
A11
BVR
non-natural (A3CON1)
14222
KVFPYALINK
|
A24
A*2402
KAS116
non-natural (A24CON1)
14223
AYIDNYNKF
|
A31
A*3101
SPACH
non-natural (A3CON1)
14224
KVFPYALINK
|
A33
A*3301
LWAGS
non-natural (A3CON1)
14225
KVFPYALINK
|
A28/68
A*6801
CIR
HBVc 141—151 T7 -> Y
14226
STLPETYVVRR
|
A28/68
A*6802
AMAI
HBV pol 646—654 C4 -> A
14227
FTQAGYPAL
|
B7
B*0702
GM3107
A2 sigal seq. 5—13
14228
APRTLVYLL
|
(L7 -> Y)
|
B8
B*0801
Steinlin
HIVgp 586—593 Y1 -> F,
14229
FLKDYQLL
|
Q5 -> Y
|
B27
B*2705
LG2
R 60s
14230
FRYNGLIHR
|
B35
B*3501
CIR, BVR
non-natural (B35CON2)
14231
FPFKYAAAF
|
B35
B*3502
TISI
non-natural (B35CON2)
14232
FPFKYAAAF
|
B35
B*3503
EHM
non-natural (B35CON2)
14233
FPFKYAAAF
|
B44
B*4403
PITOUT
EF-1 G6 -> Y
14234
AEMGKYSFY
|
B51
KAS116
non-natural (B35CON2)
14235
FPFKYAAAF
|
B53
B*5301
AMAI
non-natural (B35CON2)
14236
FPFKYAAAF
|
B54
B*5401
KT3
non-natural (B35CON2)
14237
FPFKYAAAF
|
Cw4
Cw*0401
CIR
non-natural (C4CON1)
14238
QYDDAVYKL
|
Cw6
Cw*0602
721.221 transfected
non-natural (C6CON1)
14239
YRHDGGNVL
|
Cw7
Cw*0702
721.221 transfected
non-natural (C6CON1)
14240
YRHDGGNVL
|
|
Mouse
Dh
EL4
Adenovirus EIA
14241
SGPSNTYPEI
|
P7 -> Y
|
Kh
EL4
VSV NP 52—59
14242
RGYVFQGL
|
Dd
P815
HIV-IIIB ENV
14243
RGPYRAFVTI
|
G4 -> Y
|
Kd
P815
non-natural (KdCON1)
14244
KFNPMKTYI
|
Ld
P815
HBVs 28—39
14245
IPQSLDSYWTSL
|
|
B. Class II binding assays
|
Human
DR1
DRB1*0101
LG2
HA Y307—319
14246
YPKYVKQNTLKLAT
|
DR2
DRB1*1501
L466.1
MBP 88-102Y
14247
VVHFFKNIVTPRTPPY
|
DR2
DRB1*1601
L242.5
non-natural (760.16)
14248
YAAFAAAKTAAAFA
|
DR3
DRB1*0301
MAT
MT 65kD Y3-13
14249
YKTIAFDEEARR
|
DR4w4
DRB1*0401
Preiss
non-natural (717.01)
14290
YARFQSQTTLKQKT
|
DR4w10
DRB1*0402
YAR
non-natural (717.10)
14251
YARFQRQTTLKAAA
|
DR4w14
DRB1*0404
BIN 40
non-natural (717.01)
14252
YARFQSQTTLKQKT
|
DR4w15
DRB1*0405
KT3
non-natural (717.01)
14253
YARFQSQTTLKQKT
|
DR7
DRB1*0701
Pitout
Tet. tox. 830—843
14254
QYIKANSKFIGITE
|
DR8
DRB1*0802
OLL
Tet. tox. 830—843
14255
QYIKANSKFIGITE
|
DR8
DRB1*0803
LUY
Tet. tox. 830—843
14256
QYIKANSKFIGITE
|
DR9
DRB1*0901
HID
Tet. tox. 830—843
14257
QYIKANSKFIGITE
|
DR11
DRB1*1101
Sweig
Tet. tox. 830—843
14258
QYIKANSKFIGITE
|
DR12
DRB1*1201
Herluf
unknown eluted peptide
14259
EALIHQLKINPYVLS
|
DR13
DRB1*1302
H0301
Tet. tox. 830—843
14260
QYIKANAKFIGITE
|
S -> A
|
DR51
DRB5*0101
GM3107 or L416.3
Tet. tox. 830—843
14261
QYIKANAKEIGITE
|
DR51
DRB5*0201
L255.1
HA 307—319
14262
PKYVKQNTLKLAT
|
DR52
DRB3*0101
MAT
Tet. tox. 830—843
14263
NGQIGNDPNRDIL
|
DR53
DRB4*0101
L257.6
non-natural (717.01)
14264
YARFQSQTTLKQKT
|
DQ3.1
DQA1*0301/DQB1*0301
PF
non-natural (ROIV)
14265YAHAAHAAHAAHAAHAA
|
|
Mouse
1Ab
DB27.4
non-natural (ROIV)
14266
YAHAAIIAAHAAHAAHAA
|
1Ad
A20
non-natural (ROIV)
14267
YAHAAHAAHAAHAAHAA
|
1Ak
CH-12
HEL 46-61
14268
YNTDGSTDYGILQINSR
|
1As
LS102.9
non-natural (ROIV)
14269
YAHAAHAAHAAHAAHAA
|
1Au
91.7
non-natural (ROIV)
14270
YAHAAHAAHAAHAAHAA
|
1Ed
A20
Lambda repressor 12—26
14271
YLEDARRKKAIYEKKK
|
1Ek
CH-12
Lambda repressor 12—26
14272
YLEDARRKKAIYEKKK
|
|
TABLE XXV
|
|
|
Monoclonal antibodies used in MHC purification.
|
Monoclonal antibody
Specificity
|
|
W6/32
HLA-class I
|
B123.2
HLA-B and C
|
IVD12
HLA-DQ
|
LB3.1
HLA-DR
|
M1/42
H-2 class I
|
28-14-8S
H-2 Db and Ld
|
34-5-8S
H-2 Dd
|
B8-24-3
H-2 Kb
|
SF1-1.1.1
H-2 Kd
|
Y-3
H-2 Kb
|
10.3.6
H-2 IAk
|
14.4.4
H-2 IEd, IEK
|
MKD6
H-2 IAd
|
Y3JP
H-2 IAb, IAs, IAu
|
|
TABLE XXVI
|
|
|
The table lists the 64 fully represented aligned amino acid sequences that were identified for Motif analysis. In-
|
cluded are the aligned amino acid sequence ID number, the complete nucleotide sequence name it was derived
|
from, the accession numbers for the sequence, the subtype, country and the total length of all nine sequences.
|
ID Number
Name
Accession Numbers
Subtype
Country
Length
|
|
1
A.KE.Q23-CxC-CG
HIVQ2317
AF004885
A
KE
3584
|
2
A.SE.UGSE8891
AUGSE8891
AF069673
A
SE
3584
|
3
A.UG.92UG037
H92UG037
U51190
A
UG
3584
|
4
A.UG.U455
HIVU455A
M62320
A
UG
3584
|
5
AC.IN.21301
21301
AF067156
AC
IN
3584
|
6
AC.RW.92RW009
92RW009
U88823
AC
RW
3584
|
7
AC.ZM.ZAM184
ZAM184
U86780
AC
ZM
3584
|
8
ADI.ZR.MAL
HIVMALCG
K03456, X04415
ADI
ZR
3584
|
9
AE.CF.90CR402
HIV90CF4O2
U51188
AE
CF
3584
|
10
AE.TH.93TH253
H93TH253
U51 189
AE
TH
3584
|
11
AE.TH.CM240
HIV1CM240
U54771
AE
TH
3584
|
12
AG.DJ.DJ263
DJ263
AF063223
AG
DJ
3584
|
13
AG.DJ.DJ264
HDJ264
AF063224
AG
DJ
3584
|
14
AG.NG.92NG003
92NG003
U88825
AG
NG
3584
|
15
AG.NG.92NG083
H92NG083
U88826
AG
NG
3584
|
16
AG.NG.IBNG
HIVIBNG
L39106
AG
NG
3584
|
17
AGI.CY.94CY0323
94CY032-3
AF049337
AGI
CY
3584
|
18
AGI.ZR.Z321
HIVU76035, Z321B
U76035
AGI
ZR
3584
|
19
AGJ.AU.BFP90
HIVBFP9O
AF064699
AGJ
AU
3584
|
20
B.CN.RL42
HCHRL42CG
U71182
B
CN
3584
|
21
B.DE.D31
HIV1D31
U43096
B
DE
3584
|
22
B.DE.HAN
HIVHAN2
U43141
B
DE
3584
|
23
B.FR.HXB2R
HIVHXB2
AF033819, K03455, M38432
B
FR
3584
|
24
B.GA.OYI
HIVOYI
M26727
B
GA
3584
|
25
B.GB.CAM1
HIVCAM1
D00917, D10112
B
GB
3584
|
26
B.GB.MANC
HIV1MANC
U23487
B
GB
3584
|
27
B.NL.ACH32OA
HIV1ACH32OA
U34604
B
NL
3584
|
28
B.US.ADA
HIV1AD8
AF004394
B
US
3584
|
29
B.US.DH123
HIV1DH123
AF069140
B
US
3584
|
30
B.US.JRCSF
HIVJRCSF
M38429
B
US
3584
|
31
B.US.JRFL
HIVJRFL
U63632
B
US
3584
|
32
B.US.MN
HIVMN
M17449
B
US
3584
|
33
B.US.P896
HIV1896
M96155, U39362
B
US
3584
|
34
B.US.RF
HIVRF
M12508
B
US
3584
|
35
B.US.SF2
HIVSF2CG
K02007
B
US
3584
|
36
B.US.WEAU16O
HIVWEAU160
U21135
B
US
3584
|
37
B.US.WR27
HIV1WR27
U26546
B
US
3584
|
38
B.US.YU2
HIVYU2
M93258
B
US
3584
|
39
BF.BR.93BR029.4
93BR029
AF005495
BF
BR
3584
|
40
C.BR.92BR025
H92BR025
U52953
C
BR
3584
|
41
C.BW.BW96BW0502
96BW0502
AF110967
C
BW
3584
|
42
C.ET.ETH2220
HIVETH2220
U46016
C
ET
3584
|
43
C.IN.11246
1N11246
AF067159
C
IN
3584
|
44
C.IN.21068
C1N21068
AF067155
C
IN
3584
|
45
C.IN.301904
301904
AF067157
C
IN
3584
|
46
C.IN.301905
CIN301905
AF067158
C
IN
3584
|
47
C.IN.301999
CIN301999
AF067154
C
IN
3584
|
48
D.UG.94UG1141
94UG114
U88824
D
UG
3584
|
49
D.ZR.84ZR085
84ZR085
U88822
D
ZR
3584
|
50
D.ZR.ELI
HIVELICG
K03454, X04414
D
ZR
3584
|
51
D.ZR.NDK
HIVNDK
M27323
D
ZR
3584
|
52
F.BR.93BR0201
93BR020
AF005494
F
BR
3584
|
53
F.FN.FIN9363
FIN9363
AF075703
F
FN
3584
|
54
G.BE.DRCBL
DRCBL
AF084936
G
BE
3584
|
55
G.FI.HH87931
HH8793
AF061640, AF061641
G
FI
3584
|
56
G.SE.SE6165
SE6165
AF061642
G
SE
3584
|
57
H.BE.VI991
VI991
VI991
H
BE
3584
|
58
H.BE.VI997
VI997
VI997
H
BE
3584
|
59
H.CF.90CF056
90CF056
AF005496
H
CF
3584
|
60
J.SE.SE91733
SE91733
AF082395
J
SE
3584
|
61
J.SE.SE92809
SE92809
AF082394
J
SE
3584
|
62
N.CM.YBF3O
NCMYBF3O
AJ006022
N
CM
3584
|
63
O.CM.ANT7OC
HIVANT7OC
L20587
O
CM
3584
|
64
0.CM.MVP518O
HIVMVP518O
L20571
O
CM
3584
|
|
TABLE XXVII
|
|
|
in vitro binding of conserved HIV derived peptides to HLA-A2 supertype alleles
|
Conserva-
|
pro-
1st
tion (%)
A2-supertype binding capacity (IC50 nM)
alleles
|
peptide
AA
tein
Position
Seq ID
sequence
total
B
A*0201
A*0202
A*0203
A*0206
A6802
bound
|
|
1261.14
10
NEF
221
14273
LTFGWCFKLV
55
74
294.1
48.9
185.2
57.8
6.2
5
|
|
1261.04
9
NEF
221
14274
LTFGWCFKL
61
74
35.7
33.1
4545.5
205.6
5.6
4
|
|
1261.06
9
POL
316
14275
YTAFTIPSI
58
68
26.3
6.1
9.1
7
16.7
5
|
|
1261.15
10
POL
774
14276
MASDFNLPPV
39
68
62.5
22.6
55.6
33.6
18.2
5
|
|
1069.32
9
GAG
386
14277
VLAEAMSQV
52
74
66.6
82.7
15.2
115.6
363.6
5
|
|
1261.16
10
POL
182
14278
CTLNFPISPI
94
100
147
23.9
30.3
8.4
100
5
|
|
1261.02
9
ENV
651
14279
LLQLTVWGI
53
63
9.8
215
43.5
24.7
645.2
4
|
|
1261.13
9
POL
448
14280
KLVGKLNWA
95
95
59.5
12.6
5.9
39.8
3076.9
4
|
|
1211.04
9
ENV
134
14281
KLTPLCVTL
81
95
102
126.5
66.7
185
20000
4
|
|
1261.08
9
POL
220
14282
ALVEICTEM
23
79
217.3
187
140.8
264.3
2857.1
4
|
|
1261.11
9
VPR
59
14283
AIIRILQQL
61
74
333.3
22.6
41.7
38.5
547.9
4
|
|
1261.09
9
POL
163
14284
LVGPTPVNI
84
100
454.5
153.6
19.2
2846.2
67.8
4
|
|
1261.12
9
VPR
62
14285
RILQQLLFI
56
74
19.2
1535.7
125
37
1818.2
3
|
|
1261.05
9
POL
183
14286
TLNFPISPI
97
100
75.7
1482.8
1.1
1947.4
57.1
3
|
|
1261.03
9
GAG
271
14287
MTNNPPIPV
31
89
166.6
7166.7
33.3
1608.7
12.1
3
|
|
1261.17
10
POL
132
14288
KMIGGIGGFI
97
95
172.4
54.4
4.8
770.8
3333.3
3
|
|
941.03
9
POL
498
14289
ILKEPVHGV
64
79
192.3
2388.9
6.7
37000
363.6
3
|
|
1260.10
9
POL
772
14290
RAMASDFNL
64
79
217.3
116.2
25000
52.1
3076.9
3
|
|
1261.07
9
POL
879
14291
KAACWWAGI
49
79
277.7
1075
83.3
160.9
2666.7
3
|
|
1211.09
10
ENV
814
14292
SLLNATDIAV
22
68
9.8
1303
238.1
28.5
5479.4
3
|
|
1211.05
9
ENV
608
14293
FLGAAGSTM
86
100
73.5
3583.3
1.5
4111.1
66666.7
2
|
|
25.0053
9
VPR
66
14294
QLLFIHFRI
69
89
94.3
21500
25000
1608.7
476.2
2
|
|
25.0139
10
GAG
270
14295
WMTNNPPIPV
31
89
98
3071.4
16.9
18500
2222.2
2
|
|
1069.33
10
POL
993
14296
LLWKGEGAVV
95
100
111.1
632.4
25
770.8
3636.4
2
|
|
25.0142
10
NEF
219
14297
PLTFGWCFKL
61
74
142.8
741.4
4761.9
3700
47.6
2
|
|
1069.34
9
POL
993
14298
LLWKGEGAV
97
100
172.4
10750
21.7
1608.7
2666.7
2
|
|
25.0161
10
POL
452
14299
KLNWASQIYA
42
84
217.3
3909.1
400
6166.7
3076.9
2
|
|
1211.082
9
GAG
79
14300
SLYNTVATL
34
58
277.7
3583.3
50
37000
100000
2
|
|
25.0037
9
GAG
486
14301
FLQSRPEPT
44
68
454.5
10750
32.3
18500
3076.9
2
|
|
25.0046
9
POL
91
14302
TLWQRPLVT
61
68
270.2
21500
2500
18500
2857.1
1
|
|
TABLE XXVIII
|
|
|
in vitro binding of conserved HIV derived peptides to HLA-A3 supertype alleles
|
1st
Conservation
|
pro-
Posi-
(%)
A3-supertype binding capacity (IC50 nM)
alleles
|
peptide
AA
tein
tion
Seq ID
sequence
total
B
A*0301
A*1101
A*3101
A*3301
A*6801
bound
|
|
1273.01
9
GAG
163
14303
MVHQAISPR
42
58
61.1
89.6
18.0
13.8
9.5
5
|
|
1193.0200
9
POL
572
14304
IVIWGKTPK
75
79
129.4
16.2
18.2
96.7
242.4
5
|
|
1193.03
9
POL
931
14305
AVFIHNFKR
97
100
64.7
3.3
5.1
107.4
4.2
5
|
|
1193.01
9
POL
724
14306
YLAWVPAHK
34
95
142.9
105.3
327.3
33.0
2.0
5
|
|
1211.32
10
POL
971
14307
KIQNFRVYYR
81
95
343.8
28.6
2.7
341.2
210.5
5
|
|
1069.49
10
POL
929
14308
QMAVFIHNFK
94
100
9.2
8.5
268.7
432.8
400.0
4
|
|
1273.03
10
GAG
162
14309
QMVHQAISPR
42
58
42.3
6000.0
243.2
290.0
186.0
4
|
|
1193.09
9
POL
353
14310
MTKILEPFR
67
84
13750.0
375.0
81.8
69.0
25.8
4
|
|
966.01
9
POL
347
14311
AIFQSSMTK
56
79
10.0
10.0
12000.0
96666.7
242.4
3
|
|
940.03
10
NEF
100
14312
QVPLRPMTYK
72
79
18.0
9.5
1836.7
2230.8
133.3
3
|
|
1069.43
10
ENV
48
14313
TVYYGVPVWK
64
95
11.0
3.5
1636.4
10357.1
14.5
3
|
|
1069.48
10
POL
931
14314
AVFIHNFKRK
91
100
114.6
20.7
1125.0
5000.0
307.7
3
|
|
1273.05
9
POL
99
14315
TIKIGGQLK
27
63
40.7
181.8
18000.0
36250.0
72.7
3
|
|
1273.06
9
ENV
64
14316
TLFCASDAK
81
84
118.3
11.3
10588.2
22307.7
190.5
3
|
|
1273.07
10
ENY
61
14317
TTLFCASDAK
78
84
119.6
27.3
9473.7
14500.0
140.4
3
|
|
1273.04
9
ENV
878
14318
RIVELLGRR
34
89
200.0
600.0
138.5
13809.5
444.4
3
|
|
1273.09
10
POL
98
14319
VTIKIGGQLK
27
63
297.3
28.6
10588.2
11600.0
125.0
3
|
|
1273.02
9
POL
246
14320
NTPVFAIKK
58
94.7
333.3
100.0
30000.0
48333.3
4.7
3
|
|
1150.14
9
POL
930
14321
MAVFIHNFK
94
100
647.1
20.0
375.0
517.9
2.5
3
|
|
1273.08
9
VIF
7
14322
VMIVWQVDR
69
95
3235.3
272.7
3.8
5.3
2424.2
3
|
|
1069.47
11
ENV
47
14323
VTVYYGVPVWK
64
94
84.6
11.3
4615.4 36250.0 170.2
3
|
|
1069.42
11
POL
722
14324
KVYLAWVPAHK
32
89
3.5
7.6
163.6
3580.2
8000.0
3
|
|
1069.44
9
POL
855
14325
KLAGRWPVK
78
68
8.5
133.3
500.0
72500.0
80000.0
3
|
|
TABLE XXIX
|
|
|
in vitro binding of conserved HIV derived peptides to HLA-B7 supertype alleles
|
Conserva-
|
1st
tion (%)
B7-supertype binding capacity (IC50 nM)
|
peptide
AA
protein
Position
Seq ID
sequence
total
B
B*0702
B*3501
B*5101
B*5301
B*5401
bound
|
|
1146.01
9
NEF
94
14326
FPVRPQVPL
75
74
15.7
43.0
11.6
481.9
71.4
5
|
|
1296.01
9
ENV
259
14327
IPIHYCAPA
56
42
423
343
153
—
3.7
4
|
|
15.0268
10
GAG
545
14328
YPLASLRSLF
15
32
392.9
480.0
39.3
150.0
714.3
4
|
|
1261.01
9
POL
186
14329
FPISPIETV
88
95
3437.5
1043.5
148.6
251.4
9.1
3
|
|
1296.02
9
ENV
250
14330
CPKVSFEPI
47
79
100.0
5142.9
161.8
2447.4
100.0
3
|
|
1296.03
11
POL
893
14331
IPYNPQSQGVV
92
89
458.3
72000.0
119.6
46500.0
66.7
3
|
|
29.0028
8
REV
75
14332
VPLQLPPL
56
68
112.2
6000.0
0.8
46500.0
270.3
3
|
|
1292.13
9
GAG
237
14333
HPVHAGPIA
30
74
50.0
11.6
13750.0
4428.6
4.3
3
|
|
TABLE XXX
|
|
|
A1-motif peptides
|
Conservancy
|
Peptide
Seq ID
Sequence
Protein
Total
Clade B
IC50 nM
|
|
1.0431
14334
EVNIVTDSQY
HIV pol 1187
83
93
472
|
1.0014
14335
FRDYVDRFY
HIV gag 298
51
96
278
|
|
|
|
1069.26
14338
VTVLDVGDAY
HIV pol 265
96
93
439
|
|
TABLE XXXI
|
|
|
A24-motif peptides
|
Conservancy
|
Peptide
Seq ID
Sequence
Protein
Total
Clade B
IC50 nM
|
|
25.0113
14339
IWGCSGKLI
HIV env 69
69
91
444
|
25.0127
14340
IYETYGDTW
HIV vpr 92
92
100
207
|
1069.60
14341
IYQEPFKNL
HIV pol 1036
74
87
444
|
25.0128
14342
PYNEWTLEL
HIV vpr 56
56
71
86
|
25.0123
14343
PYNTPVFAI
HIV pol 74
74
100
387
|
|
|
|
|
1069.59
14346
TYQIYQEPPF
HIV pol 1033
78
93
67
|
|
|
|
|
25.0219
14349
YWQATWIPEW
HIV pol 96
96
93
182
|
|
TABLE XXXII
|
|
|
Immunogenicity of A2-supertype cross-reactive binding peptides
|
Conservancy
Immunogenicity
|
Peptide
SEQ ID
Sequence
Protein
Total
Clade B
XRN
patients
transgenic
|
|
|
|
|
1261.06
14352
YTAFTIPSI
HIV pol 316
58
68
5
0/1
0/6
|
1261.15
14353
MASDFNLPPV
HIV pol 774
39
68
5
1/15
2/6
|
1069.32
14354
VLAEAMSQV
HIV gag 386
52
74
5
6/19
3/3
|
1261.16
14355
CTLNFPISPI
HIV pol 182
94
100
5
0/1
1/6
|
1261.02
14356
LLQLTVWGI
HIV env 651
53
63
4
2/8
1/6
|
1261.13
14357
KLVGKLNWA
HIV pol 448
95
95
4
3/15
3/3
|
1211.04
14358
KLTPLCVTL
HIV env 134
85
95
4
2/12
2/6
|
1261.08
14359
ALVEICTEM
HIV pol 220
23
79
4
0/2
1/6
|
1261.11
14360
AIIRILQQL
HIV vpr 59
61
74
4
5/9
0/6
|
1261.09
14361
LVGPTPVNI
HIV pol 163
84
100
4
1/9
1/6
|
1261.12
14362
RILQQLLFI
HIV vpr 62
56
74
3
6/20
2/6
|
1261.05
14363
TLNFPISPI
HIV pol 183
97
100
3
1/7
0/6
|
1261.03
14364
MTNNPPIPV
HIV gag 271
31
89
3
2/17
4/6
|
1261.17
14365
KMIGGIGGFI
HIV pol 132
97
95
3
2/7
0/6
|
941.03
14366
ILKEPVHGV
HIV pol 498
64
79
3
8/19
3/6
|
1261.10
14367
RAMASDFNL
HIV pol 772
64
79
3
2/9
0/6
|
1261.07
14368
KAACWWAGI
HIV pol 879
49
79
3
1/8
0/6
|
1211.09
14369
SLLNATDIAV
HIV env 814
22
68
3
|
|
TABLE XXXIII
|
|
|
Immunogenicity of HIV-derived A3-supertype peptides
|
Conservancy
Immunogenicity
|
Peptide
SEQ ID
Sequence
Protein
Total
Clade B
XRN
transgenic
patients
|
|
|
|
|
1193.09
14380
MTKILEPFR
HIV pol 353
67
84
4
0/8
|
966.01
14381
AIFQSSMTK
HIV pol 347
56
79
3
5/6
1/6
|
940.03
14382
QVPLRPMTYK
HIV nef 100
72
79
3
0/6
6/10
|
1069.44
14383
KLAGRWPVK
HIV pol 855
78
68
3
|
1273.02
14384
NTPVFAIKK
HIV pol 246
58
95
3
0/6
|
1273.08
14385
VMIVWQVDR
HIV vif 7
69
95
3
0/6
|
1273.04
14386
RIVELLGRR
HIV env 878
34
89
3
|
|
|
|
|
TABLE XXXIV
|
|
|
HLA-DR screening panels
|
Screening
Representative Assay
Phenotypic Frequencies
|
Panel
Antigen
Alleles
Allele
Alias
Cauc.
Blk.
Jpn.
Chn.
Hisp.
Avg.
|
|
Primary
DR1
DRB1*0101-03
DRB1*0101
(DR1)
18.5
8.4
10.7
4.5
10.1
10.4
|
DR4
DRB1*0401-12
DRB1*0401
(DR4w4)
23.6
6.1
40.4
21.9
29.8
24.4
|
DR7
DRB1*0701-02
DRB1*0701
(DR7)
26.2
11.1
1.0
15.0
16.6
14.0
|
Panel total
59.6
24.5
49.3
38.7
51.1
44.6
|
Secondary
DR2
DRB1*1501-03
DRB1*1501
(DR2w2 β1)
19.9
14.8
30.9
22.0
15.0
20.5
|
DR2
DRB5*0101
DRB5*0101
(DR2w2 β2)
—
—
—
—
—
—
|
DR9
DRB1*09011, 09012
DRB1*0901
(DR9)
3.6
4.7
24.5
19.9
6.7
11.9
|
DR13
DRB1*1301-06
DRB1*1302
(DR6w19)
21.7
16.5
14.6
12.2
10.5
15.1
|
Panel total
42.0
33.9
61.0
48.9
30.5
43.2
|
Tertiary
DR4
DRB1*0405
DRB1*0405
(DR4w15)
—
—
—
—
—
—
|
DR8
DRB1*0801-5
DRB1*0802
(DR8w2)
5.5
10.9
25.0
10.7
23.3
15.1
|
DR11
DRB1*1101-05
DRB1*1101
(DR5w11)
17.0
18.0
4.9
19.4
18.1
15.5
|
Panel total
22.0
27.8
29.2
29.0
39.0
29.4
|
Quarternary
DR3
DRB1*0301-2
DRB1*0301
(DR3w17)
17.7
19.5
0.4
7.3
14.4
11.9
|
DR12
DRB1*1201-02
DRB1*1201
(DR5w12)
2.8
5.5
13.1
17.6
5.7
8.9
|
Panel total
20.2
24.4
13.5
24.2
19.7
20.4
|
|
TABLE XXXV
|
|
|
cross-reactive HLA-DR binding peptides
|
|
|
Binding capacity (IC50 nM)
|
Peptide
SEQ ID
Sequence
Protein
DR1
DR2w2β1
DR2w2β2
DR3
DR4w4
DR4w15
DR5w11
|
|
27.0313
14393
KRWIILGLNKIVRMY
HIV gag 298
4.2
5.1
24
188
633
404
54
|
|
27.0354
14394
WEFVNTPPLVKLWYQ
HIV pol 596
7.2
222
2.1
13636
28
20
317
|
|
27.0377
14395
QKQITKIQNFRVYYR
HIV pol 956
2.9
3.4
80
—
357
49
53
|
|
1280.03
14396
KVYLAWVPAHKGIGG
HIV pol 712
8.3
25
24
—
156
165
71
|
|
27.0311
14397
GEIYKRWIILGLNKI
HIV gag 294
82
138
225
—
1667
380
213
|
|
27.0361
14398
EKVYLAWVPAHKGIG
HIV pol 711
3.6
21
4.9
3226
9.3
27
37
|
|
27.0297
14399
QHLLQLTVWGIKQLQ
HIV env 729
6.1
21
690
—
1316
345
2128
|
|
27.0304
14400
QGQMVHQAISPRTLN
HIV gag 171
72
65
13
17647
60
400
—
|
|
27.0344
14401
SPAIFQSSMTKILEP
HIV pol 335
357
217
667
—
3571
109
741
|
|
F091.15
14402
IKQFINMWQEVGKAMY
HIV env 566
128
217
206
—
417
271
4878
|
|
27.0341
14403
FRKYTAFTIPSINNE
HIV pol 303
185
70
4167
—
294
136
1818
|
|
27.0364
14404
HSNWRAMASDFNLPP
HIV pol 758
33
—
125
—
11
15
95
|
|
27.0373
14405
KTAVQMAVFIHNFKR
HIV pol 915
161
650
690
—
909
452
182
|
|
Binding capacity (IC50 nM)
|
Peptide
SEQ ID
Sequence
Protein
DR5w12
DR6w19
DR7
DR8w2
DR9
DR53
bound
|
|
27.0313
14393
KRWIILGLNKIVRMY
HIV gag 298
124
0.36
379
49
58
12
|
|
27.0354
14394
WEFVNTPPLVKLWYQ
HIV pol 596
1355
90
15
350
39
10
|
|
27.0377
14395
QKQITKIQNFRVYYR
HIV pol 956
124
25
25
75
577
11
|
|
1280.03
14396
KVYLAWVPAHKGIGG
HIV pol 712
12598
2500
179
196
250
9
|
|
27.0311
14397
GEIYKRWIILGLNKI
HIV gag 294
1656
98
192
63
536
9
|
|
27.0361
14398
EKVYLAWVPAHKGIG
HIV pol 711
6478
3500
18
31
144
9
|
|
27.0297
14399
QHLLQLTVWGIKQLQ
HIV env 729
1064
350
44
907
375
8
|
|
27.0304
14400
QGQMVHQAISPRTLN
HIV gag 171
—
412
455
7313
117
8
|
|
27.0344
14401
SPAIFQSSMTKILEP
HIV pol 335
—
13
68
3267
33
8
|
|
F091.15
14402
IKQFINMWQEVGKAMY
HIV env 566
—
1000
—
350
5769
104
8
|
|
27.0341
14403
FRKYTAFTIPSINNE
HIV pol 303
—
—
30
803
39
7
|
|
27.0364
14404
HSNWRAMASDFNLPP
HIV pol 758
—
4375
472
1960
872
7
|
|
27.0373
14405
KTAVQMAVFIHNFKR
HIV pol 915
18625
125
1786
1441
2586
7
|
|
A dash indicates IC50 > 20 μM
|
TABLE XXXVI
|
|
|
DR3 binding peptides
|
Peptide
Seq ID
Sequence
Protein
DR3
|
|
35.0135
14406
YRKILRQRKIDRLID
HIV vpu 31
23
|
|
35.0131
14407
WAGIKQEFGIPYNPQ
HIV pol 874
300
|
|
35.0127
14408
EVNIVTDSQYALGII
HIV pol 674
732
|
|
35.0125
14409
AETFYVDGAANRETK
HIV pol 619
769
|
|
35.0133
14410
GAVVIQDNSDLKVVP
HIV pol 989
1000
|
|
TABLE XXXVII
|
|
|
Immunogenicity of HIV-derived DR-supermotif peptides
|
DR
|
Conservation(%)
Alleles
Patient
|
Peptide
Seq ID
Sequence
Protein
total
clad B
bound
Immunogenicity
|
|
|
|
|
27.0354
14113
WEFVNTPPLVKLWYQ
HIV pol 596
79 [89]
84 [95]
10
3/13
|
27.0377
14114
QKQITKIQNFRVYYR
HIV pol 956
56 [67]
95 [95]
11
3/13
|
|
|
|
|
27.0304
14117
QGQMVHQAISPRTLN
HIV gag 171
41 [42]
52 [58]
8
4/13
|
27.0344
14118
SPAIFQSSMTKILEP
HIV pol 335
52 [59]
79 [78]
8
3/13
|
27.0341
14119
FRKYTAFTIPSINNE
HIV pol 303
59 [58]
68 [68]
7
3/13
|
27.0364
14120
HSNWRAMASDFNLPP
HIV pol 758
48 [67]
68 [79]
7
3/13
|
27.0373
14121
KTAVQMAVFIHNFKR
HIV pol 915
87 [95]
94 [100]
7
4/13
|
|
1conservation of core region
|
TABLE XXXVIII
|
|
|
Candidate CTL Epitopes
|
Restriction
Peptide
Protein
Seq ID
Sequence
|
|
HLA-A2
1069.32
HIV gag 386
14122
VLAEAMSQV
|
″
1261.03
HIV gag 271
14123
MTNNPPIPV
|
″
1261.15
HIV pol 774
14124
MASDFNLPPV
|
″
1261.13
HIV pol 448
14125
KLVGKLNWA
|
″
1261.09
HIV pol 163
14126
LVGPTPVNI
|
″
941.03
HIV pol 498
14127
ILKEPVHGV
|
″
1261.07
HIV pol 879
14128
KAACWWAGI
|
″
1261.17
HIV pol 132
14129
KMIGGIGGFI
|
″
1261.10
HIV pol 772
14130
RAMASDFNL
|
″
1261.05
HIV pol 183
14131
TLNFPISPI
|
″
1211.04
HIV env 134
14132
KLTPLCVTL
|
″
1261.02
HIV env 651
14133
LLQLTVWGI
|
″
1211.09
HIV env 163
14134
SLLNATDIAV
|
″
1261.04
HIV nef 221
14135
LTFGWCFKL
|
″
1261.11
HIV vpr 59
14136
AIIRILQQL
|
″
1261.12
HIV vpr 62
14137
RILQQLLFI
|
|
HLA-A3
1069.49
HIV pol 929
14138
QMAVFIHNFF
|
″
1069.42
HIV pol 722
14139
KVYLAWVPAI
|
″
1211.32
HIV pol 971
14140
KIQNFRVYYR
|
″
1193.09
HIV pol 353
14141
MTKILEPFR
|
″
966.01
HIV pol 347
14142
AIFQSSMTK
|
″
1273.09
HIV pol 98
14143
VTIKIGGQLK
|
″
1273.07
HIV env 61
14144
TTLFCASDAK
|
″
1069.47
HIV env 47
14145
VTVYYGVPVV
|
″
940.03
HIV nef 100
14146
QVPLRPMTYK
|
″
1273.08
HIV vif 7
14147
VMIVWQVDR
|
″
1273.03
HIV gag 162
14148
QMVHQAISPF
|
|
HLA-B7
15.0268
HIV gag 545
14149
YPLASLRSLF
|
″
1292.13
HIV gag 237
14150
HPVHAGPIA
|
″
1261.01
HIV pol 186
14151
FPISPIETV
|
″
1296.03
HIV pol 893
14152
IPYNPQSQGV
|
″
1296.01
HIV env 259
14153
IPIHYCAPA
|
″
1296.02
HIV env 250
14154
CPKVSFEPI
|
″
1146.01
HIV nef 94
14155
FPVRPQVPL
|
″
29.0028
HIV rev 75
14156
VPLQLPPL
|
|
HLA-A1
1.0431
HIV pol 684
14157
EVNIVTDSQY
|
″
1.0014
HIV gag 317
14158
FRDYVDRFY
|
″
1069.27
HIV pol 368
14159
VIYQYMDDLY
|
″
1069.26
HIV pol 295
14160
VTVLDVGDAY
|
|
HLA-A24
1069.60
HIV pol 533
14161
IYQEPFKNL
|
″
25.0123
HIV pol 244
14162
PYNTPVFAI
|
″
1069.59
HIV pol 530
14163
TYQIYQEPF
|
″
25.0219
HIV pol 597
14164
YWQATWIPEV
|
″
25.0113
HIV env 681
14165
IWGCSGKLI
|
″
1069.57
HIV env 671
14166
RYLKDQQLL
|
″
25.0115
HIV env 55
14167
VWKEATTTLF
|
″
25.0127
HIV vpr 46
14168
IYFTYGDTW
|
″
25.0128
HIV vpr 14
14169
PYNEWTLEL
|
|
TABLE XXXIX
|
|
|
HTL Candidate Epitopes
|
Selec-
|
tion
|
Criteria
Peptide
Seq ID
Sequence
Protein
|
|
DR
27.0313
14170
KRWIILGLNKIVRMY
HIV gag 298
|
27.0354
14171
WEFVNTPPLVKLWYQ
HIV pol 596
|
27.0377
14172
QKQITKIQNFRVYYR
HIV pol 956
|
1280.03
14173
KVYLAWVPAHKGIGG
HIV pol 712
|
27.0311
14174
GE1YKRWIILGLNKI
HIV gag 294
|
27.0361
14175
EKVYLAWVPAHKGIG
HIV pol 711
|
27.0297
14176
QHLLQLTVWGIKQLQ
HIV env 729
|
27.0304
14177
QGQMVHQAISPRTLN
HIV gag 171
|
27.0344
14178
SPAIFQSSMTKILEP
HIV pol 335
|
F091.15
14179
IKQFLNMWQEVGKAMY
HIV env 566
|
27.0341
14180
FRKYTAFTIPSINNE
HIV pol 303
|
27.0364
14181
HSNWRAMASDFNLPP
HIV pol 758
|
27.0373
14182
KTAVQMAVFIHNFKR
HIV pol 915
|
|
DR3
35.0135
14183
YRKILRQRKIDRLID
HIV vpu 31
|
35.0131
14184
WAGIKQEFGIPYNPQ
HIV pol 874
|
35.0127
14185
EVNIVTDSQYALGII
HIV pol 674
|
35.0125
14186
AETFYVDGAANRETK
HIV pol 619
|
35.0133
14187
GAVVIQDNSDIKVVP
HIV pol 989
|
|
TABLE XL
|
|
|
Estimated population coverage by a panel of HIV derived HTL epitopes
|
Representative
No. of
Population coverage (phenotypic frequency)
|
Antigen
Alleles
assay
epitopes2
Cauc.
Blk.
Jpn.
Chn.
Hisp.
Avg.
|
|
DR1
DRB1*0101-03
DR1
13
18.5
8.4
10.7
4.5
10.1
10.4
|
DR2
DRB1*1501-03
DR2w2 β1
12
19.9
14.8
30.9
22.0
15.0
20.5
|
DR2
DRD5*0101
DR2w2 β2
12
—
—
—
—
—
—
|
DR3
DRB1*0301-2
DR3
5
17.7
19.5
0.40
7.3
14.4
11.9
|
DR4
DRB1*0401-12
DR4w4
10
23.6
6.1
40.4
21.9
29.8
24.4
|
DR4
DRB1*0401-12
DR4w15
13
—
—
—
—
—
—
|
DR7
DRB1*0701-02
DR7
11
26.2
11.1
1.0
15.0
16.6
14.0
|
DR8
DRB1*0801-5
DR8w2
9
5.5
10.9
25.0
10.7
23.3
15.1
|
DR9
DRB1*09011, 09012
DR9
11
3.6
4.7
24.5
19.9
6.7
11.9
|
DR11
DRB1*1101-05
DR5w11
9
17.0
18.0
4.9
19.4
18.1
15.5
|
DR13
DRB1*1301-06
DR6wl9
8
21.7
16.5
14.6
12.2
10.5
15.1
|
Total1
98.5
95.1
97.1
91.3
94.3
95.1
|
|
1Total opulation coverage has been adjusted to acount for the presence of DRX in many ethnic populations. It has been assumed that the range of specificities represented by DRX alleles will mirror those of previously characterized HLA-DR alleles. The proportion of DRX incorporated under each motif is representative of the frequency of the motif in the remainder of the population. Total coverage has not been adjusted to account for unknown gene types.
|
2Number of epitopes represents a minimal estimate, considering only the epitopes shown in Table 13. Additional alleles possibly bound by nested epitopes have not been accounted.
|