Information processing apparatus, information processing method, information processing system, program, and recording medium

Abstract

Disclosed herein is an information processing apparatus, method, system, and program, and a recording medium. An information processing apparatus includes an acquisition unit, an arithmetic unit, and an output control unit. The acquisition unit acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic unit receives from the acquisition unit the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control unit controls the output of the score which has been calculated by the arithmetic unit for the cellular function.

Description

CROSS REFERENCES TO RELATED APPLICATIONS

The present invention contains subject matter related to Japanese Patent Application JP 2005-266728, filed in the Japanese Patent Office on Sep. 14, 2005, the entire contents of which being incorporated herein by reference.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to an information processing apparatus, method, system, and program, and a recording medium. More particularly, the present invention relates to an information processing apparatus, method, system, and program, and a recording medium, which are intended to digitize the relation between intermolecular interactions and cellular functions.

2. Description of Related Art

There are many diseases involving gene defects. They include genetic metabolic diseases induced by a single gene defect as well as cancerous diseases induced by a plurality of gene defects which have accumulated with time. Analyzing whether a specific gene (and its product) is normal or abnormal is important in understanding the origin of a disease and establishing the plan for medical treatment.

This has been generally achieved by the technique which involves investigating the copy number of a specific gene of interest, confirming the degree of transcription of the gene, performing DNA sequencing on the amplified product of RT-PCR of the gene, detecting mutation by the thus obtained base sequence, and confirming immunohistochemically the localization of the gene at the protein level or the change in expression of the gene. This technique has helped accumulate a large amount of knowledge, some of which is used as an essential method for clinical test.

The copy number of the gene may be investigated by using the Southern blotting technique, which involves treating a sample with a restriction enzyme, transferring the treated sample to a nitrocellulose membrane by electrophoresis, and hybridizing the transferred sample to find a specific base sequence. The degree of transcription of the gene may be investigated by using the Northern blotting technique, which involves separating RNA by gel electrophoresis, transferring the separated RNA to a nylon membrane, hybridizing the transferred RNA with a labeled probe, and detecting the desired molecules.

These classic techniques of the first generation are followed by the new techniques of the second generation, which are designed to examine a very large number of genes and proteins comprehensively at one time. They have been developed for the human genome project, which needs to examine a large number of genes comprehensively at one time. Nowadays, comprehensive analyses are carried out not only for genes (genome) but also for RNAs (transcriptome), proteins (proteome), and metabolites (metabolome). Many methods have been devised to utilize the resulting data for disease diagnosis and medical treatment.

There have been proposed many methods for studying how a change in mRNA affects a disease by computer analysis of comprehensive data originating from transcriptome which is a collection of mRNAs or all of transcription products in a cell. Among them is a method for knowing the property of cancer and devising the medical treatment of cancer by analyzing the expression profile of mRNA and other molecular data. For example, refer to following Patent Documents 1 to 9.

Patent Document 1:

Japanese Patent Laid-open No. 2005-34151,

Patent Document 2:

Japanese Patent Laid-open No. 2004-329211,

Patent Document 3:

JP-A-2005-514051,

Patent Document 4:

JP-A-2005-512557,

Patent Document 5:

JP-A-2005-514359,

Patent Document 6:

JP-A-2005-518522,

Patent Document 7:

JP-A-2005-500832,

Patent Document 8:

JP-A-2005-503779,

Patent Document 9:

JP-A-2005-508199.

There has been disclosed a technique for a drawing a graph that shows nodes representing proteins and edges representing their interactions and then visualizing it three-dimensionally by using a parameter called spring force. (For example, see Patent Document 10: Japanese Patent Laid-open No. 2004-118819.)

There has also been disclosed a technique for visualizing by means of nodes and links a table that shows interactions and their intensity between objects such as proteins. (For example, see Patent Document 11: Japanese Patent Laid-open No. 2004-30034.)

SUMMARY OF THE INVENTION

Unfortunately, the techniques disclosed in Patent Documents 1 to 9 above are designed to analyze comprehensive data, abstract their feature, and find their relation with specific diseases. They do not give any information about how a set of data of gene increase or decrease relates with specific diseases. Even though they provide the relation between the presence of gene expression cluster and the clinical data, they do not indicate the significance of the relation. Therefore, they do not permit one to ascertain the difference between meaningful data fluctuation and meaningless data fluctuation due to sample preparation for comprehensive data.

In addition, the techniques disclosed in Patent Documents 10 and 11 make intermolecular interactions visual but have no way of digitizing and predicting intermolecular interactions.

The present invention was completed in view of the foregoing. It is intended to digitize the relation between intermolecular interactions and cellular functions.

The first embodiment of the present invention is directed to an information processing apparatus which includes acquisition means, arithmetic means, and output control means. The acquisition means acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means controls the output of the score which has been calculated by the arithmetic means for the cellular function.

In the information processing apparatus, the acquisition means acquires the amount of the molecules for detection which have been produced by the control cells and the sample cells, according to the amount of the nucleic acid which has been expressed in response to the molecules for detection which have been collected from the control cells and the sample cells.

In the information processing apparatus, the combination of the two molecules for detection is classified into the following five categories according to the interrelation between the two molecules; the first category applicable to two molecules which suppress each other, the second category applicable to two molecules the first one of which promotes the second one and the second one of which suppresses the first one, the third category applicable to two molecules which promote each other, the fourth category applicable to two molecules only one of which promotes the other, and the fifth category applicable to two molecules only one of which suppresses the other.

In the information processing apparatus, the arithmetic means calculates the score for the cellular functions by accumulating for each cellular function those values which are obtained by giving the score based on the amount of the molecules for detection which have been produced in the control cells and the sample cells to the cellular functions relating to the mutual promotion or suppression between the two molecules for detection which belong to the first to third categories out of the five categories and then multiplying a prescribed factor.

In the information processing apparatus, the prescribed factor is established such that it takes on the largest value for the cellular function relating to the first category of the first to third categories out of the five categories and it also takes on the smallest value for the cellular function relating to the third category of the first to third categories out of the five categories.

In the information processing apparatus, the prescribed factor is larger than 1 when the two molecules for detection have a molecular bond.

The information processing apparatus further includes storage means that stores in a table form the information about the combination of the two molecules for detection which are classified into any of the five categories and the cellular function relating to the mutual promotion or suppression of the two molecules for detection.

The information processing apparatus further includes estimating means that estimates the score for the cellular function when there is any change in the amount of the molecules for detection which have been produced in the control cells and the sample cells after it has been acquired by the acquisition means.

The information processing apparatus further includes network building means that builds a network for the information about the interrelation of the molecules for detection, so that the estimating means calculates the effect of change in the amount of the molecules for detection which have been produced on other molecules based on the network which has been built by the network building means, thereby estimating the score for the cellular function.

The information processing apparatus further includes analyzing means that analyzes the change with time of the cellular function based on the score for the cellular function, with its output being controlled by the output control means.

The second embodiment of the present invention is directed to an information processing method or an information processing program which includes the steps of acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells, receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.

The third embodiment of the present invention is directed to an information processing system which includes an analyzing unit that analyzes the amount of the molecules for detection which have been produced in the control cells and the sample cells and an information processing apparatus that analyzes the information about the cellular function relating to the mutual promotion or suppression of the two molecules for detection. The information processing apparatus has acquisition means, arithmetic means, and output control means. The acquisition means acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means controls the output of the score which has been calculated by the arithmetic means for the cellular function.

The information processing system includes the steps of acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells, receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.

The network denotes any setup which consists of at least two apparatus connected to each other so that information can be transmitted from one apparatus to the other. The apparatus capable of communication through the network may be those which are independent from one another or those which are constituent units of one apparatus.

The term “communication” means wireless and wire communications or a mixture thereof. In the latter case, wireless communication may be carried out in some sections and wire communication may be carried in other sections. Another mode of communication may be such that wire communication is carried out from the first apparatus to the second apparatus and wireless communication is carried out from the second apparatus to the first apparatus.

The above-mentioned information processing apparatus according to the present invention is able to analyze the cellular function relating to the molecules for detection. It is also able to classify the overall relation between molecules, thereby digitizing the relation between the intermolecular interaction and the cellular function.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram illustrating a protein analyzing system to which the present invention is applied;

FIG. 2 is a diagram illustrating the classification of the interrelation between two molecules;

FIGS. 3A to 3F are diagrams illustrating the relation between the NN-type molecules and the cellular function;

FIGS. 4A to 4H are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 5A to 5H are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 6A to 6H are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 7A to 7G are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 8A to 8G are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 9A to 9F are diagrams illustrating the relation between the PN-type molecules and the cellular function;

FIGS. 10A to 10G are diagrams illustrating the relation between the PP-type molecules and the cellular function;

FIGS. 11A to 11G are diagrams illustrating the relation between the PP-type molecules and the cellular function;

FIGS. 12A to 12G are diagrams illustrating the relation between the PP-type molecules and the cellular function;

FIGS. 13A to 13G are diagrams illustrating the relation between the PP-type molecules and the cellular function;

FIGS. 14A to 14F are diagrams illustrating the relation between the PP-type molecules and the cellular function;

FIG. 15 is a diagram illustrating the relation between the NN-type molecules and the cellular function;

FIG. 16 is a diagram illustrating the relation between the PN-type molecules and the cellular function;

FIG. 17 is a diagram illustrating the relation between the PP-type molecules and the cellular function;

FIG. 18 is a diagram illustrating how to calculate the cell score;

FIG. 19 is a diagram illustrating how to calculate the cell score;

FIG. 20 is a diagram illustrating the simulation which is carried out when the prescribed cell score is changed;

FIG. 21 is a diagram illustrating one example of the molecule network;

FIG. 22 is a flow chart illustrating the process for analysis;

FIG. 23 is a flow chart illustrating the process for accumulating points;

FIG. 24 is a flow chart illustrating the process 1 for inferring the target molecule;

FIG. 25 is a flow chart illustrating the process 2 for inferring the target molecule; and

FIG. 26 is a diagram illustrating the structure of a personal computer.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The following is a detailed description of the embodiments according to the present invention. This description is intended to ensure that the embodiments according to the present invention conform to the specification and drawings therein. The embodiments may include those which have the constituents of the present invention which are not shown in the specification or the drawings therein. This does not necessarily mean that such embodiments do not correspond to the constituents of the present invention. Conversely, even though some embodiments may be written as conforming to the constituents of the present invention, it does not necessarily mean that such embodiments do not conform to other constituents than the constituents.

The information processing apparatus according to the present invention has acquisition means (such as the arithmetic unit 21 shown in FIG. 1 which calculates the ratio of the amount of protein expressed) that acquires the amount of the molecules for detection which have been produced by control cells (such as normal cells) and sample cells, arithmetic means (such as the point accumulating unit 22 shown in FIG. 1) that receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells (such as the ratio of protein expressed which is inferred from the amount of mRNA expressed or measured by the protein kit 7), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection, and output control means (such as the result output unit 28 shown in FIG. 1) that controls the output of the score which has been calculated by the arithmetic means for the cellular function.

The combination of the two molecules for detection is classified into the following five categories according to the interrelation between the two molecules; the first category (such as NN-type) applicable to two molecules which suppress each other, the second category (such as PN-type) applicable to two molecules the first one of which promotes the second one and the second one of which suppresses the first one, the third category (such as PP-type) applicable to two molecules which promote each other, the fourth category (such as N-type) applicable to two molecules only one of which promotes the other, and the fifth category (such as P-type) applicable to two molecules only one of which suppresses the other.

The information processing apparatus may additionally have storage means (such as the protein information database 3) that stores in a table form (shown in FIGS. 3 and 4) the information about the combination of the two molecules for detection which are classified into any of the five categories (as shown in Tables 1 to 7) and the cellular function relating to the mutual promotion or suppression of the two molecules for detection.

The information processing apparatus may additionally have inferring means (such as the target molecule inferring unit 27 shown in FIG. 1) that infers the score for the cellular function when there is any change in the amount of the molecules for detection which have been produced in the control cells and the sample cells after it has been acquired by the acquisition means.

The information processing apparatus may additionally have network building means (such as the network building unit 26 shown in FIG. 1) that builds a network for the information about the interrelation of the molecules for detection, so that the inferring means calculates the effect of change in the amount of the molecules for detection which have been produced on other molecules based on the network which has been built by the network building means, thereby inferring the score for the cellular function.

The information processing apparatus may additionally have analyzing means (such as the result analyzing unit 6 shown in FIG. 1) that analyzes the change with time of the cellular function based on the score for the cellular function, with its output being controlled by the output control means.

The information processing method or program according to the present invention includes the step of acquiring the amount of the molecules for detection which have been produced in the control cells (such as normal cells) and the sample cells (the step being represented by Step S3 in FIG. 22), and the step of receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells (the information being the ratio of expression of protein), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection (the step being represented by Step S5 in FIG. 22 or the process explained with reference to FIG. 23).

The information processing system according to the present invention includes an analyzing unit (such as the mRNA expression analyzing unit 2 shown in FIG. 1) that analyzes the amount of the molecules for detection which have been produced in the control cells (such as normal cells) and the sample cells and an information processing apparatus (such as the protein information analyzing unit 4 shown in FIG. 1) that analyzes the information about the cellular function relating to the mutual promotion or suppression of the two molecules for detection. The information processing apparatus has acquisition means, arithmetic means, and output control means. The acquisition means (such as the arithmetic unit 21 shown in FIG. 1 calculates the ratio of the amount of protein expressed) that acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means (such as the point accumulating unit 22 shown in FIG. 1) receives from the acquisition means the information about the amount of the molecules for detection which have been produced by said control cells and said sample cells (said information being the ratio of protein expressed), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means (such as the result output unit 28 shown in FIG. 1) controls the output of the score which has been calculated by the arithmetic means for the cellular function.

The embodiment of the present invention will be described with reference the accompanying drawings.

FIG. 1 is a block diagram illustrating the structure of the protein information analyzing system to which the present invention is applied.

The protein information analyzing system includes the chip forming unit 1, the mRNA expression analyzing unit 2, the protein information database 3, the protein information analyzing unit 4, the result display unit 5, and the result analyzing unit 6. It may also have the protein kit 7.

The chip forming unit 1 yields a DNA chip (or DNA microarray) which has as the probe a nucleic acid with the base sequence structure complementary to the molecule (protein) for detection.

The mRNA expression analyzing unit 2 is so designed as to drop the control target and the detection target onto the DNA chip which has been prepared by the chip forming unit 1, thereby determining the amount of the molecule (protein) for detection in each case. The control target is produced by the mRNA collected from the normal cell (control cell), and the detection target is obtained by reverse transcription (for duplication) of the complementary DNA (cDNA) from the mRNA collected from the sample cell. In other words, the mRNA expression analyzing unit 2 performs hybridization, which utilizes the reaction to form the complementary strands (double strands) between nucleic acids each having the complementary base sequence, and then determines, by fluorescence intensity analysis with an intercalator, the amount of the molecule (protein) for detection which has been expressed in the normal cell and the amount of the molecule (protein) for detection which has been expressed in the sample cell, and supplies the thus obtained result to the protein information analyzing unit 4.

The foregoing units may be replaced by the protein kit 7, which is designed to detect comprehensively the molecules (proteins) for detection by using protein chips.

The protein information database 3 stores information about the protein to be used for processing by the protein information analyzing unit 4. The protein information database 3 may be connected, by wire or wireless (e.g., through the Internet or LAN or WAN network), directly to the protein information analyzing unit 4. It may also be installed inside the protein information analyzing unit 4.

The combination of two different protein molecules can be classified into five categories according to their intermolecular interactions. The protein information database 3 stores information about the classification of the combination of two protein molecules belonging to each category. (The classification is referred to as molecule set.)

As shown in FIG. 2, the combinations of two molecules (or the intermolecular interrelations between two molecules) are classified into five categories (NN-type, PN-type, PP-type, P-type, and N-type) according to whether one molecule promotes or suppresses the other.

The NN-type denotes a combination in which two molecules suppress each other. The two molecules in the NN-type combination function as the molecular switch, with one representing “ON” if it dominates over the other quantitatively and functionally, and the other representing “OFF”.

The PN-type denotes a combination in which the first molecule promotes the second molecule and the second molecule suppresses the first molecule. In other words, two molecules perform contradictory functions (promotion and suppression) on each other. In this case, the information about the molecule for promotion converges on a certain value with oscillation as the result of negative feedback.

The PP-type denotes a combination in which two molecules promote each other. While two molecules are promoting each other, the information about the two molecules is amplified as the result of positive feedback.

The P-type denotes a combination in which one molecule promotes the other. The N-type denotes a combination in which one molecule suppresses the other.

Tables 1 to 9 show the NN-type combination (molecule set) of molecules.

	TABLE 1
	Protein A		Protein B
	A2N	NN	LRPAP1
	A2N	NN	PLG
	ABO	NN	EGF
	ACE	NN	ANGPTA
	ACE	NN	BDK
	ACE	NN	CIIorf3
	ACE	NN	cyclic GNP
	ACE	NN	HHL
	ACE	NN	E
	ACE	NN	TACI
	ACHE	NN	acetylthiocholine
	ACHE	NN	BCHE
	ADCY2	NN	AGTR1
	ADCY2	NN	CHR1
	ADCY2	NN	DRD2
	ADCY2	NN	EDN1
	ADCY2	NN	GR2
	ADCY2	NN	NPPA
	ADCY2	NN	P2Y receptor
	ADCY2	NN	phospholipase C
	ADCY2	NN	RAF1
	ADCY2	NN	SSTR5
	ADCY2	NN	TNFO1
	ADRBK1	NN	GRK5
	ADRBK1	NN	RPS6K
	AFP	NN	TP53
	AGT	NN	ADCY2
	AGT	NN	ANG
	AGT	NN	KCKD3
	AGT	NN	prosteglandin-
			endoperoxide synthase
	AGTR1	NN	AGTR2
	AGTR1	NN	cAYP
	AHR	NN	estradiol
	AKT1	NN	BAK
	AKT1	NN	FOS
	AKT1	NN	GRB2
	AKT1	NN	PCK2
	AKT1	NN	PIK2B
	AKT1	NN	PTPK6
	AKT1	NN	RAP1GA1
	AKT1	NN	TKFAIP8
	ALB	NN	ELA2
	ALB	NN	FUT4
	ALB	NN	hyaluronoglucuronidase
	ALB	NN	Na+, K+ ATPase
	ananain	NN	BDK
	ANGPT2	NN	ACK
	APAF1	NN	ABL1
	APC	NN	CCND1
	APC	NN	SNADA
	APOA1	NN	cholesteryl ester
	APOE	NN	LRPAP1
	AOP2	NN	AOP3
	ARF6	NN	TFAP2A
	AVP	NN	CRHP1
	AVP	NN	REN
	BAD	NN	BAK1
	BAX	NN	BCL2
	Bbaa1l	NN	SELE
	BCAR1	NN	GNB2L1
	BCAR1	NN	NEDD9
	BCL2	NN	anyloid protein
	BCL2	NN	BAK1
	BCL2	NN	HRK
	BCL2	NN	NR3C1
	BCL2	NN	PDCD3
	BCL2	NN	TNFAIP8
	BCL2	NN	TNFRSF6

	TABLE 2
	Protein A		Protein B
	BCL2L1	NN	BAK1
	BCL2L1	NN	BID
	BCL2L1	NN	sphingosine
	BCL2L1	NN	TNFRASF6
	BCL6	NN	PRDH1
	BDK	NN	ANP
	BDK	NN	DNOLI
	BDK	NN	NNE
	BDK	NN	TGFA
	beta-o-glucose	NN	CAT
	oxidase
	BF	NN	SERPING1
	BH2HB2	NN	BHLHB3
	BIO	NN	TRFAIP8
	BIRC3	NN	CASP3
	BIRC3	NN	TNFSF10
	BHP4	NN	BRP4 receptor
	BHP4	NN	PITX2
	BHP4	NN	tumor necrosis factor
	BU618	NN	CDC2
	CALCA	NN	calmodulin
	calmodulin	NN	ADREX1
	calmodulin	NN	ELK1
	calmodulin	NN	GAP43
	calmodulin	NN	SHAD2
	calpain	NN	APOE
	calpain	NN	NEXBIA
	CALR	NN	calcitriol
	casein kinase	NN	GJA1
	CASP3	NN	BIRC2
	CASP3	NN	CD28
	CASP3	NN	CDC42
	CASP3	NN	COLI1A1
	CASP3	NN	dihydrosphingosine
			kinase
	CASP3	NN	HSPB2
	CASP3	NN	IGF2
	CASP3	NN	map kinase
	CASP3	NN	NCL1
	CAT	NN	CASP3
	CAT	NN	cytokine activity
	CAT	NN	HIFIA
	CAT	NN	HNOK1
	CAT	NN	LP0
	CAT	NN	HAPKAP1
	catecholamine	NN	mitochondrial
			processing peptidase
	CAV1	NN	ADCY2
	CAV1	NN	FGF2
	CAV1	NN	HDL
	CBL	NN	TCN2
	CCL2	NN	GJA1
	CCL2	NN	RGS1
	CCL2	NN	RGS3
	CCL2	NN	RGS4
	CCL42	NN	CYP2E1
	CCNNA2	NN	CDKN2A
	CCNA2	NN	RBL2
	CCND1	NN	CDKN2A
	CCND1	NN	GSK3B
	CCND1	NN	PPARA
	CCND1	NN	PPARG
	CCNE1	NN	STAT3
	CCNE1	NN	RBI
	CCNE1	NN	SNARCA4
	CCR5	NN	coreceptor
	CD4	NN	PRF1
	CDB6	NN	CD28
	CDA	NN	SLC9A3
	CCDC2	NN	CDKNIA
	CDC2	NN	NYT1
	CDC2	NN	PAPOLA
	CDC2	NN	RB1
	CDC2	NN	NEE1
	CDC42	NN	GD1
	CDC42	NN	NLC1
	CDH1	NN	CDC2
	CDH1	NN	CDC20

	TABLE 3
	Protein A		Protein B
	CDK2	NN	CDK2AP1
	CDK2	NN	CIB1
	CDK2	NN	PSND9
	CDK2	NN	SNARCA4
	CDK4	NN	HYOD1
	CDK5	NN	CDC2
	CDK5	NN	CDKN2A
	CDK6	NN	CDKN1A
	CDKN1A	NN	E2F4
	CDKN1A	NN	GSK3B
	CDKN1B	NN	CHX10
	CDKN1B	NN	CISH
	CDKN1B	NN	IL3
	CDKN1B	NN	RHOA
	CDKN1B	NN	SOCS3
	CDKN1B	NN	transcription factor
	CDKN2A	NN	CDKN26
	CDKN2B	NN	RBI
	CEBPB	NN	cANP
	CEBPB	NN	CTNNB1
	CEBPG	NN	tumor necrosis factor
	chloroxazone	NN	CYP2E1
	cholesterol	NN	CAV1
	cholesterol	NN	PPARA
	choline-phosphate	NN	RIPK2
	cytidylyltransferase
	CISH	NN	SHOC2
	CNTF	NN	ADCYAP1
	CREB1	NN	CALCA
	CREB1	NN	CREBBP
	CREB1	NN	GSK3B
	CREB1	NN	NAPK11
	CREB1	NN	protein phosphate 1
	CREB1	NN	PTPN1
	CSF1	NN	INPP50
	CSF2	NN	CCR5
	CTNNA1	NN	ITGB1
	CTSS	NN	CST3
	CYCS	NN	ABL1
	CYCS	NN	DAP13
	CYCS	NN	POR
	CYP1A1	NN	estrogens
	CYP2D6	NN	Cyp3a11
	CYP2E1	NN	CYP1A1
	CYP3A4	NN	CYP3A5
	CYP3A4	NN	NET
	DAP	NN	ODC1
	DAPK1	NN	integrin
	deacetylase	NN	HOAC1
	DFFB	NN	UTP
	DIABLO	NN	BIRC4
	DUSPI	NN	RAS small monomeric
			GTPase
	E2FI	NN	PRB2
	E2FI	NN	SERPINE1
	E3	NN	DIABLO
	EBP	NN	tumor necrosis factor
	EDN1	NN	BDK
	EDN1	NN	cANP
	EDN1	NN	estradiol
	EDN1	NN	estrosen
	EDN1	NN	LPL
	EDN1	NN	progesterone
	EDNRA	NN	AGTR1
	EGF	NN	ASCL1
	EGF	NN	CLU
	EGF	NN	CTSB
	EGF	NN	GCG
	EGF	NN	IGFBP2
	EGF	NN	HYE
	EGF	NN	TGFB2
	EGFR	NN	ANH
	EGFR	NN	LRTG1
	EGFR	NN	PAKCA
	EGFR	NN	SLC29A1
	EGLN3	NN	HIF1A

	TABLE 4
	Protein A		Protein B
	EGR1	NN	SP3
	ELA2	NN	ELN
	ELA2	NN	SERPINA3
	ELA2	NN	TINP1
	EPH44	NN	WAP2K4
	EPX	NN	H2O2
	ERBB2	NN	CAV1
	ERBB2	NN	progesterone
	ERBB2	NN	RHOB
	ERK activator	NN	PPARA
	kinase
	F10	NN	protein C (activated)
	F2	NN	PIP2
	FGF1	NN	FIBP
	FGF2	NN	GSK3B
	FGF2	NN	HPSE
	FGF2	NN	NFXBIA
	FGF2	KH	THBS1
	FN1	NN	ACTA2
	FN1	NN	CDC42
	FN1	NN	PLAU
	FOS	NN	CEBPA
	FOS	NN	KLK3
	FOS	NN	Ha+/K+ ATPase
	FOXO1A	NN	PPARG
	FXN	NN	INHBA
	FYN	NN	DUSP1
	GATA1	NN	SPI1
	GCG	NN	DPP4
	GCG	NN	ENTPD2
	GH1	NN	ITIH4
	GHA0	NN	Phosphatidylinositol
			3-Kinase
	GNB2L1	NN	CTNNA2
	GNRH1	NN	HR3C1
	GNRH1	NN	SST
	GPC3	NN	IGF2
	GPI	NN	IGFBP3
	GRB2	NN	PDGFRB
	GRB2	NN	PSKD9
	GRPR	NN	BRS3
	GRPR	NN	NEBR
	GSK3B	NN	CDKN1B
	GSK3B	NN	IRS2
	GSK3B	NN	RPS6KB1
	GSK3B	NN	Nnt
	GSTN1	NN	VAP3K5
	GTP	NN	CALCA
	GTP	NN	POFK1
	HAND2	NN	IL13
	HDAC1	NN	HDAC2
	HDAC4	NN	HEF2A
	HDL	NN	LPL
	HES1	NN	NEUROG3
	HGF	NN	interleukin IL12
	HGF	NN	THBS1
	histone deacetylase	NN	CFTR
	histone deacetylase	NN	E2F4
	HVGA2	NN	CCL2
	HRF4A	NN	NO
	HOXB1	NN	EGR2
	HRAS	NN	RHOB
	HSPA4	NN	caspase
	HSPA4	NN	PKC
	HSPB1	NN	DAKX
	ICAN1	NN	SELL
	ICAN1	NN	TNFRSFG
	IFNG	NN	cytochrome P450
	IFNG	NN	EP300
	IFHG	NN	IL10
	IFHG	NN	IL13
	IFHG	NN	IL17
	IFNG	NN	IL5
	IFNG	NN	PPARG
	IGF1	NN	ADCY2
	IGF1	NN	GDG
	IGF1	NN	HSPCA
	IGF1	NN	ILIF8
	IGF1	NN	LIF
	IGF1	NN	turor necrosis factor

	TABLE 5
	Protein A		Protein B
	IGF2	NN	H19
	IGFALS	NN	IGF2
	IGFBP1	NN	IGF2
	IGFBP1	NN	IGFBP2
	IGFBP3	NN	chorionic gonadotropin
	IL1	NN	NR3C1
	IL10	NN	lectin
	IL10	NN	NNP9
	IL13	NN	interleukin IL13
			receptor
	IL18	NN	CASP3
	IL18	NN	IL1R1
	IL18BP	NN	IL18
	IL1A	NN	estradiol
	IL1A	NN	PRKCA
	IL1A	NN	thyroid stimulating
			hormone
	IL1B	NN	CCL21
	IL1B	NN	cytochrome P450
	IL1B	NN	EP0
	IL1B	NN	GHRL
	IL1B	NN	HNF4A
	IL1B	NN	NFKB1B
	IL1B	NN	SDC1
	IL1B	NN	SPARC
	IL1B	NN	TIVP3
	IL1F8	NN	ELK
	IL1F8	NN	NFKBIA
	IL1F8	NN	SP3
	IL1R1	NN	PTGS2
	IL1R1	NN	tumor necrosis factor
	IL2	NN	ELA2
	IL2	NN	PAX5
	IL2	NN	TGFB2
	IL4	NN	ALOX5
	IL4	NN	B7H3
	IL4	NN	CXCL9
	IL4	NN	FGF2
	IL4	NN	IFNA1
	IL4	NN	TNPO1
	IL4	NN	TRERF1
	IL4	NN	VIP
	IL5RA	NN	IL5
	IL6	NN	APOE
	IL6	NN	CDKH1A
	IL6	NN	CYP1A2
	IL6	NN	cytochrome P450
	IL6	NN	GFI1B
	IL6	NN	NTP
	IL6	NN	NYB
	IL6	NN	PPARG
	IL6	NN	RB1
	IL6	NN	SELL
	IL6	NN	vitamin D
	INS	NN	alpha2 adrenoceptor
	INS	NN	ARRB1
	INS	NN	cAMP-dependent protein
			kinase, catalyst
	INS	NN	CYP2E1
	INS	NN	DPP4
	INS	NN	epinephrine
	INS	NN	GAL
	INS	NN	glycogen synthase
			kinase 3
	INS	NN	IFNG
	INS	NN	LDL
	INS	NN	PFKFB1
	INS	NN	phosphoenolpyruvate
			carboxykinase
	INS	NN	PLTP
	INS	NN	protein tyrosine
			phosphatase
	INS	NN	PTGIS
	INS	NN	Rho kinase
	INS	NN	RHOA
	INS	NN	TERF2IP
	INS	NN	tumor necrosis factor
	INS	NN	VLDL

	TABLE 6
	Protein A		Protein B
	interleukin IL12	NN	IL5
	IRAN4	NN	TLR4
	IRF4	NN	BCL6
	IRF4	NN	IFNA1
	IRS2	NN	TRS4
	ITIH4	NN	OCR5
	ITK	NN	CDH1
	JAK1	NN	PTPN6
	JAK2	NN	PTPN6
	JAK2	NN	SOCS3
	JAK2	NN	TYRP1
	JUN	NN	AR
	JUN	NN	CDK2
	JUN	NN	CEBPA
	JUN	NN	CTLA4
	JUN	NN	Na+/K+ ATPase
	JUN	NN	NR3C1
	KIT	NN	PTPN6
	LCP1	NN	ELA2
	LCP1	NN	SERPING1
	LCP1	NN	TFP1
	LEP	NN	CDH1
	LEP	NN	GAL
	LEP	NN	GCG
	LEP	NN	RB1
	LEP	NN	serotonin
	LEP	NN	SST
	ligase	NN	EGFR
	LOX	NN	HRAS
	LPA	NN	cAMP
	LPA	NN	DGPP phosphatase
	LPL	NN	LIPC
	LPL	NN	phosphatidylcholine
	LPL	NN	TG
	LYZ	NN	HIST1H4D
	NADO	NN	TNFRSFIA
	nap kinase	NN	ADRBK1
	nap kinase	NN	NYOD1
	nap kinase	NN	PTEN
	NAP3K1	NN	NAPK3IPI
	NAPK1	NN	BRF1
	NAPK1	NN	CAV1
	NAPK1	NN	CDC2
	NAPK1	NN	DUSP2
	NAPK1	NN	NOS3
	NAPK1	NN	pathway-specific SNAD
			protein
	NAPK1	NN	PTPN6
	NAPK1	NN	RAP16A1
	NAPK10	NN	CDK5
	NAPK14	NN	IT6A4
	NAPK14	NN	Phosphatidyl inositol
			3-kinase
	NAPK14	NN	TXN
	NAPK14	NN	XDH
	NAPK3	NN	EPHB2
	NAPK3	NN	protein phosphatase 2A
	NAPK8	NN	CAV1
	NAPK8	NN	IL4
	NAPK8	NN	NPPA
	NAPK8	NN	PPARA
	NAPK8	NN	protein tyrosine
			phosphatase
	NAPK8	NN	PSEN1
	NAPK8	NN	RARA
	matrix	NN	HYP9
	metalloproteinase
	NHC2TA	NN	IL10
	NNP2	NN	THBS2
	NNP9	NN	gelatin
	HYP9	NN	TIYP3
	NP0	NN	LTF
	NSYB	NN	LTA
	HTBP	NN	EP300
	NUC2	NN	PTGS2

	TABLE 7
	Protein A		Protein B
	NYC	NN	BCL2
	NYC	NN	CAV1
	NYC	NN	BDKN1A
	NYC	NN	CDKN2B
	NYC	NN	CE8PA
	NYC	NN	EP300
	NYC	NN	IFNA1
	NYC	NN	INHBA
	NYC	NN	NYOD1
	NYC	NN	pathway-specific SNAD
			protein
	NYC	NN	ZBTB16
	NYOD1	NN	RAS small monomeric
			GTPase
	NGFB	NN	CDK2
	NGFB	NN	EPAS1
	NGFB	NN	NO
	NGFB	NN	STAT3
	norepinephrine	NN	LEP
	NOS2A	NN	ARG1
	NOS2A	NN	GAPH1
	NOS2A	NN	HNOX1
	NOS2A	NN	RHOA
	NPPA	NN	ANP32A
	NPPA	NN	D9Ngc42e
	NPPA	NN	PRKG1
	NPY	NN	Ca-ATPase
	NPY	NN	GHRH
	NR3C1	NN	NFIC
	NR3C1	NN	Nuclear factor NF
			kappa B
	NTRK1	NN	NGFR
	PARP1	NN	CASP6
	PARP1	NN	cytokine activity
	pathway-specific	NN	EP300
	SNAD protein
	PANR	NN	BCL2
	PAK5	NN	SPI1
	PDPK1	NN	PPP1R13B
	PGR	NN	Nuclear factor NF
			kappa B
	PGR	NN	RELA
	Phosphatidylinositol	NN	CASP3
	3-kinase
	Phosphatidylinositol	NN	CASP9
	3-kinase
	PIK3CA	NN	PTEN
	PKA	NN	CXCL12
	PLA2G18	NN	HTATIP
	PLA2G18	NN	phosphatidylcholine
	PLG	NN	SERPINB5
	PLG	NN	SERPINF2
	PNA	NN	CDK2
	PONC	NN	ascorbic acid
	PONC	NN	doparine D2 receptor
	PPARA	NN	Nuclear factor NF
			kappa B
	PPARA	NN	STAT58
	PPARA	NN	tumor necrosis factor
	PPARG	NN	KLF2
	PPARG	NN	Nuclear factor NF
			kappa B
	PPARG	NN	STAT58
	PRDH1	NN	PAX5
	PRKCA	NN	DGKZ
	PRKCA	NN	protein phosphatase 2A
	PRKCA	NN	PTHLH
	PRKCA	NN	TNFRSF6
	PRL	NN	ANXA5
	PRL	NN	DHT
	protein phosphatase	NN	EGFR
	protein phosphatase 1	NN	RPS6KB1
	protein phosphatase 1	NN	SYK
	protein tyrosine	NN	PRKCD
	phosphatase
	PRV1	NN	ubiquitin
	PSEN1	NN	PSEN2
	PSEN1	NN	SAP kinase

	TABLE 8
	Protein A		Protein B
	PSND9	NN	CDK6
	PSND9	NN	RAS small monomeric
			GTPase
	PTEN	NN	BCAR1
	PTEN	NN	CREB1
	PTEN	NN	Nuclear factor NF
			kappa B
	PTEN	NN	RPS6K
	PTEN	NN	TNFRSF6
	PTEN	NN	tumor necrosis factor
	PTGS2	NN	cANP
	PTGS2	NN	GSK3B
	PTGS2	NN	NUC5AC
	PTGS2	NN	PPARG
	PTH	NN	TNFRSFI1B
	PTHLH	NN	BHLHB2
	PTK2B	NN	BCL2L1
	PTK2B	NN	CHRN1
	PTPN6	NN	receptor signaling
			protein
	RAC1	NN	EFNA1
	RAC1	NN	GDI
	RAC1	NN	GNA12
	RAC1	NN	PTK2
	RAC1	NN	RAC2
	RAF1	NN	CAV1
	RAF1	NN	GAP
	RAF1	NN	NO
	RAF1	NN	RASGRF1
	RARA	NN	CREBBP
	RARA	NN	UBE1L
	RARA	NN	VDR
	RB1	NN	BRCA1
	RB1	NN	COKN2A
	RB1	NN	INHBA
	RB1	NN	NDY2
	RBL1	NN	E2F1
	RBL2	NN	E2F1
	REN	NN	ACE
	REN	NN	RENBP
	RGS4	NN	NOS3
	RHOA	NN	cyclic GNP
	RHOA	NN	myosin phosphatase
	RHOA	NN	PKA
	RPS6KB1	NN	PIK3RI
	SCT	NN	CALCA
	SELL	NN	CD44
	SERPINA1	NN	ELA2
	SERPINE1	NN	protein C (activated)
	SERPINF2	NN	PLAUR
	SKIL	NN	SNAD2
	SLC9A3	NN	SLC9A1
	SNAD3	NN	NYOD1
	SOD2	NN	CAT
	SOD2	NN	PGE
	SPARC	NN	FGF2
	SPI1	NN	GATA2
	SRC	NN	CSK
	src family	NN	LCK
	src family	NN	CSK
	SST	NN	ADCY2
	SST	NN	IAPP
	SST	NN	ILIA
	SST	NN	PPY
	SST	NN	TRH
	STAT3	NN	INHBA
	STAT5A	NN	CDKN1B
	STAT5A	NN	ESR2
	STAT5A	NN	SOCS3
	STAT6	NN	Nuclear factor NF
			kappa B
	sterol	NN	LDLR
	superoxide	NN	NOS3
	dismutase
	SYK	NN	fibrinogen
	TAC1	NN	noradrenaline
	TAC1	NN	NPY
	TAC1	NN	SST
	TEK	NN	ANGPT2
	TERF2IP	NN	GAP

	TABLE 9
	Protein A		Protein B
	TGFB1	NN	BF
	TGFB1	NN	EGPT
	TGFB1	NN	CA1
	TGFB1	NN	CCHA2
	TGFB1	NN	DCN
	TGFB1	NN	ENTP02
	TGFB1	NN	ESR1
	TGFB1	NN	FOXG18
	TGFB1	NN	GFPT1
	TGFB1	NN	HGF
	TGFB1	NN	IGFBP1
	TGFB1	NN	KITL6
	TGFB1	NN	HYC
	TGFB1	NN	nitric oxide synthase
	TGFB1	NN	NOS2A
	TGFB1	NN	PAX8
	TGFB1	NN	PGF
	TGFB1	NN	PRL
	TGFB1	NN	RBL1
	TGFB1	NN	RELA
	TGFB1	NN	TIE
	TGFB1	NN	TTF2
	thioredoxin	NN	TXN
	reductase (nadph)
	TP1	NN	S100A4
	TP2	NN	GHP3
	TNF	NN	ABCC2
	TNF	NN	ACDC
	TNF	NN	ADCY2
	TNF	NN	ALB
	TNF	NN	ANBP
	TNF	NN	CYP11A1
	TNF	NN	CYP17A1
	TNF	NN	EDNRA
	TNF	NN	FLT1
	TNF	NN	GATA3
	TNF	NN	insulin receptor
	TNF	NN	TRAK1
	TNF	NN	NFXBIB
	TNF	NN	PPARG
	TNF	NN	PROS1
	TNF	NN	protein phosphatase 1
	TNF	NN	REN
	TNF	NN	SFTPC
	TNF	NN	THBS1
	TNFRSF1A	NN	CCL4
	TNFRSF6	NN	CXCL9
	TNFRSF7	NN	TL10
	TP53	NN	ABOC1
	TP53	NN	BIRC3
	TP53	NN	BRCA2
	TP53	NN	CAK complex
	TP53	NN	CDKN1B
	TP53	NN	DAXX
	TP53	NN	FGF2
	TP53	NN	HSPA4
	TP53	NN	NAP4
	TP53	NN	NR3C1
	TP53	NN	PSEN1
	TP53	NN	RAD51
	TP53	NN	telonerase
	TP53	NN	TERT
	TP53	NN	TXNRD1
	turor necrosis	NN	IL5
	factor	NN	NFKBIA
	ubiquitin
	UTP	NN	ATPase
	VDR	NN	PWA
	VEGF	NN	TNFSF15
	VIP	NN	DAP
	VIP	NN	NPY
	WT1	NN	EGFR
	WT1	NN	PVA
	YY1	NN	SREBF1
	ZFPN1	NN	GATA3

Tables 10 to 35 show the PN-type combination (molecule set) of molecules.

	TABLE 10
	Protein A		Protein B
	14-3-3	PN	RAF1
	1-phosphetioyl inositol-	PN	HSNB
	4-phosphate 5-kinase
	5-HT2 receptor	PN	DRD2
	ABCB1	PN	IL2
	ABL1	PN	BCR
	ABL1	PN	HRAS
	ABL1	PN	IL7
	ABL1	PN	MAP3K1
	ABL1	PN	MAPK8
	ABL1	PN	NYBBP1A
	ABL1	PN	NYC
	ABL1	PN	protein tyrosine kinase
	ABL1	PN	PTPN1
	ABL1	PN	STAT1
	ABL1	PN	STAT5A
	ABL1	PN	transcription factor
	ACE	PN	EDN1
	ACE	PN	EGR1
	ACE	PN	TGFB1
	ACE	PN	TNF
	acid phosphatase	PN	KLK3
	activin	PN	SNAD2
	ACTN1	PN	ABL1
	ACVR1	PN	SYAD3
	ADANTSL1	PN	FN1
	ADCYAP1	PN	JUN
	ADD1	PN	LEP
	ADD1	PN	SREBF1
	ADP	PN	GCG
	ADP	PN	HSPA4
	ADP	PN	HSPCA
	ADP	PN	IL18
	ADP	PN	TP53
	ADRB3	PN	INS
	ADRBK1	PN	NAPK3
	AFP	PN	ALB
	AGRN	PN	CDC42
	AGT	PN	ARG2
	AGT	PN	HHOX1
	AGT	PN	HTATIP
	AGT	PN	LEP
	AGT	PN	HAPK9
	AGT	PN	PLA2G1B
	AGT	PN	PPARG
	AGT	PN	PTGIS
	AGT	PN	PTH
	AGT	PN	PTHLH
	AGT	PN	PTK2
	AGT	PN	PTPNI1
	AGT	PN	RHOA
	AGT	PN	SERP1NE1
	AGT	PN	SRC
	AGTR1	PN	RHOA
	AGTR2	PN	NGF8
	AGTR2	PN	IP53
	AHR	PN	CYP1A1
	AKT1	PN	BCL2
	AKT1	PN	caspase
	AKT1	PN	ERK activator kinase
	AKT1	PN	fatty acids
	AKT1	PN	FOXD1
	AKT1	PN	IGFBP5
	AKT1	PN	HAP2K2
	AKT1	PN	HR3C1
	AKT1	PN	oxygen
	AKT1	PN	PIK3R1
	AKT1	PN	protein phosphatase 2A
	AKT1	PN	RHC8
	AKT1	PN	TNFSF6
	ALB	PN	FN1
	ALB	PN	TL6
	ALB	PN	PTGFS
	ALB	PN	TGFB1
	aldosterone	PN	ADH
	alphaVbeta6	PN	NNF9

	TABLE 11
	Protein A	Protein B
	AVH	PN	IFNG
	aminopeptidase	PN	BDK
	ANGPT2	PN	BDK
	ANGPT4	PN	BDK
	APC	PN	HYC
	APEK1	PN	JUN
	APOE	PN	APP
	APP	PN	IGF1R
	APP	PN	PTGS2
	APPBP1	PN	TP53BP2
	AR	PN	BCL2
	AR	PN	KLK3
	arachidonic acid	PN	CAT
	arachidonic acid	PN	CYP2E1
	arachidonic acid	PN	EGFR
	arachidonic acid	PN	GAP43
	ARG2	PN	AGTR1
	ARHGEF11	PN	PTK2
	ARHGEF7	PN	CDC42
	ARHGEF7	PN	PAK1
	ATF1	PN	CREB1
	ATF1	PN	TGFB1
	ATPase	PN	MAPK6
	ATR	PN	CHEK1
	AVP	PN	AKT1
	BAD	PN	AKT1
	BAD	PN	PKA
	BAG1	PN	HSPA4
	BAX	PN	BCL2L1
	BCAR1	PN	RAC1
	B-cell receptor	PN	PLCG1
	BCL2	PN	IFNG
	BCL2	PN	YDN2
	BCL2	PN	RAS small monomeric
			GTPase
	BCL2	PN	RU-486
	BCL2L1	PN	DSIPI
	BCL2L1	PN	MAPK1
	BCL2L1	PN	HFKBIA
	BCL6	PN	TKFRSF5
	BDK	PN	ADH
	BDK	PN	RAC1
	BDK	PN	RHOA
	BDK	PN	SELP
	BDNF	PN	NAPK3
	beta adrenoceptor	PN	GCG
	BGN	PN	RAC1
	BGN	PN	RHOA
	BID	PN	BAX
	BikIk	PN	BCL2L1
	BIRC4	PN	PRSS25
	BIRC4	PN	TGFB1
	BIRC5	PN	AGT
	BIRC7	PN	DIABLO
	blood coagulation	PN	IL6
	factor XII
	BYP15	PN	KITLG
	BYP2	PN	BYP4
	BYP2	PN	SYAD4
	BYP2	PN	TGFB1
	BYP4	PN	CASP3
	BYP4	PN	CASP8
	BRCA1	PN	CASP3
	BRCA1	PN	HAPK3
	C11orf3	PN	BDK
	CAK complex	PN	CCNA2
	CAK complex	PN	CDK4
	CALCA	PN	YAPK1
	CALCA	PN	YAPK3
	CALCA	PN	POYC
	calcineurin	PN	ELK1
	calcineurin	PN	NAPK8
	calcineurin	PN	NEF2A
	calcium	PN	PTGIS
	calcium	PN	TAC1
	calmodulin	PN	GCG
	calmodulin	PN	NAPK1

	TABLE 12
	Protein A	Protein B
	cAYP	PN	AGT
	cANP	PN	AKT1
	cANP	PN	CXCR4
	cAYP	PN	FGF2
	cAYP	PN	INHBA
	cAYP	PN	KITLG
	cAYP	PN	HPY
	cANP	PN	SST
	carbon tetrachloride	PN	CYP2E1
	CASP1	PN	IL18
	CASP3	PN	BIRC5
	CASP3	PN	TGF1
	CASP3	PN	TAC1
	CASP3	PN	TNF
	CASP7	PN	BCL2
	CASP7	PN	NAP3K1
	CASP8	PN	TNFATP8
	CASP8	PN	TRAF2
	CASP9	PN	BCL2L1
	CASP9	PN	BIRC4
	caspase	PN	IGF1
	caspase	PN	IL8
	CAT	PN	CYCS
	catecholamines	PN	CRH
	catecholamines	PN	LIF
	catecholamines	PN	NPPA
	catenin	PN	AR
	catenin	PN	PTGS2
	catenin	PN	TP53
	CAV1	PN	CD36
	CAV1	PN	ESR1
	CAV1	PN	PKA
	CBL	PN	SH3KBP1
	CCAL1	PN	NAPK1
	CCK	PN	CALCA
	CCK	PN	GCG
	CCK	PN	MAPK1
	CCK	PN	MAPK3
	CCK	PN	NGF3
	CCK	PN	PLA2G1B
	CCK	PN	POVC
	CCK	PN	SST
	CCL2	PN	WAPK8
	CCL21	PN	IL10
	CCL21	PN	WAPK1
	CCL21	PN	TNF
	CCL4	PN	TGF81
	CCL5	PN	CCL2
	CCL5	PN	IL2
	CCL5	PN	IL8
	CCNA2	PN	CDK6
	CCNA2	PN	CDKN16
	CCNB1	PN	CDKN1A
	CCND1	PN	CDK2
	CCND1	PN	CDKN1B
	CCND1	PN	CDX1
	CCND1	PN	E2F1
	CCND1	PN	RASSF1
	CCND1	PN	RPS6KB1
	CCND1	PN	TCF4
	CCND1	PN	TGFB1
	CCND2	PN	CDK4
	CCND2	PN	FOKO3A
	CCND2	PN	INHBA
	CCNE1	PN	CDKN1A
	CCNE1	PN	TP53
	CCR3	PN	CCL11
	CCR5	PN	CXCR3
	CD14	PN	IL4
	CD14	PN	TGFB1

	TABLE 13
	Protein A	Protein B
	CD24	PN	CD4
	CD28	PN	CHUK
	CD28	PN	IL10
	CD28	PN	TGFB1
	CD28	PN	TNF
	CD28	PN	TNFSF6
	CD4	PN	BCL2L1
	CD4	PN	LCK
	CD44	PN	LFA-1 (integrin)
	CD80	PN	CD28
	CD80	PN	IL10
	CD81	PN	LCK
	CD86	PN	IL10
	CD8A	PN	CCR5
	CD8A	PN	IL10
	CD9	PN	IFNG
	CDC2	PN	HIST2H3C
	CDC2	PN	RPS6KB1
	CDC25A	PN	14-3-3
	CDC25B	PN	CCNA2
	CDC25C	PN	ATR
	CDC25C	PN	CCNA2
	CDC42	PN	AKT1
	CDC42	PN	FegamaRI
	CDC42	PN	NAP3K1
	CDC42	PN	NAP3K4
	CDC42	PN	RPS6KB1
	CDH2	PN	YAPK1
	CDK2	PN	CDC25A
	CDK2	PN	CDK3
	CDK2	PN	CDKN1B
	CDK2	PN	PCNA
	CDK5	PN	CDKN1A
	CDK5	PN	PSND9
	CDK5	PN	TP53
	CDK7	PN	CCNH
	CDKN1A	PN	AHPN/CD437
	CDKN1A	PN	CCKD2
	CDKN1A	PN	Cyp2b20
	CDKN1A	PN	FOS
	CDKN1A	PN	RALGDS
	CDKN1B	PN	CKS1A
	CDKN1B	PN	EGF
	CDKN1A	PN	platelet-derived growth
			factor
	CDKN1B	PN	PSVD9
	CDKN1B	PN	RBL2
	CDKN1B	PN	RPS6K
	CDKN1B	PN	SKP2
	CDT1	PN	GWIH
	CEBPA	PN	acetyltransferase
	CEBPA	PN	SP1
	CEBPB	PN	NR3C1
	CEBPB	PN	TGFB1
	CETP	PN	INS
	CHEK1	PN	TP53
	CHEK2	PN	TP53
	chorionic	PN	TGFA
	gonadotropin
	CIDEA	PN	DFFA
	CIDEB	PN	DFFA
	CLK1	PN	PTCH
	CNTF	PN	LIFR
	CNTF	PN	SOCS3
	CNTFR	PN	LIFR
	COPS5	PN	JUN
	cortisol	PN	GH1
	cortisol	PN	LEP
	CREB1	PN	SOD2
	CRH	PN	GH1
	CRH	PN	PDNC
	CRH	PN	SST

	TABLE 14
	Protein A	Protein B
	CSF1	PN	COC42
	CSF1	PN	FN1
	CSF1	PN	NYP2
	CSF1	PN	PPARG
	CSF1	PN	PTK2
	CSF1	PN	PTPH6
	CSF1	PN	SHC1
	CSF2	PN	IFHA1
	CSF2	PN	IFNG
	CSF2	PN	IL10
	CSF2	PN	IL4
	CSF2	PN	IL8
	CSF2	PN	PPARG
	CSF2	PN	RARA
	CSF2	PN	STAT1
	CSF3	PN	EGR1
	CSF3	PN	EMI1
	CSF3	PN	MAP2X5
	CSF3	PN	Phosphatidylinesitol
			3-kinase
	CSF3	PN	RUNX1
	CSF3	PN	SOCS1
	CSF3	PN	SOCS3
	CSF3	PN	STAT5A
	CSF3	PN	TGFB1
	CSF3R	PN	STAT1
	CSK	PN	PXN
	CTNNB1	PN	DKK1
	CTNNB1	PN	TCF4
	CTNNB1	PN	TP53
	CTSB	PN	TGFB1
	CTTN	PN	SRC
	CX3CL1	PN	TLiR1
	CX3CR1	PN	CX3CL1
	CXCL1	PN	PKC
	CXCL12	PN	CXCR4
	CXCL12	PN	PTK2B
	CXCL12	PN	RAC1
	CXCL12	PN	TNF
	CXCL13	PN	IL10
	CXCR4	PN	CCL2
	CXCR4	PN	CCR5
	CXCR4	PN	TL8
	cyclase	PN	DRD2
	cyclase	PN	NGF3
	cyclin	PN	CDH1
	cyclin-dependent	PN	BCL2
	protein kinase
	cyclin-dependent	PN	CDK2
	protein kinase
	cyclin-dependent	PN	CDKN1B
	protein kinase
	CYCS	PN	BCL2
	CYP1A1	PN	TFNG
	CYP1A1	PN	TGFB1
	CYP3A4	PN	CYP2E1
	CYRG1	PN	TP53
	cytochrone P450	PN	TNF
	dATP/ATP	PN	CASP9
	DAXX	PN	MAP3K5
	DAXX	PN	MAPK8
	DCE	PN	CYP2E1
	DCN	PN	RAC1
	DCN	PN	RHDA
	DCN	PN	TNF
	DIN	PN	CREB1
	DIN	PN	TGFA
	d-lysine	PN	PLAT
	DNA topoiscaerase	PN	TP53
	(ATP hydrolyzing)
	DNA-dependent	PN	ABL1
	protein kinase
	DNA-dependent	PN	ATN
	protein kinase
	DNASE1L3	PN	PARP1
	DNN1	PN	SRC
	DNN2	PN	CTTN
	DOCK1	PN	TERF2P
	dopemine	PN	PTH
	dopamine D1 receptor	PN	DRD2

	TABLE 15
	Protein A	Protein B
	DRD2	PN	FOS
	DYL1	PN	AKT1
	DYRK16	PN	MAPK14
	DYRK16	PN	TCF1
	E2	PN	AKT1
	E2	PN	CASP3
	E2F1	PN	BCL2
	E2F1	PN	BCL2L11
	E2F1	PN	CCHA2
	E2F1	PN	CDKN1A
	E2F1	PN	TOPEP1
	E2F1	PN	TP53
	E2F4	PN	RBL2
	EAT2	PN	PGF
	ECE1	PN	EDN1
	EDN1	PN	CAV1
	EDH1	PN	DUSP1
	EDN1	PN	GH1
	EDK1	PN	GNA0
	EDN1	PN	LPA
	EDN1	PN	MAP2K1
	EDN1	PN	MAPK1
	EDN1	PN	MAPK3
	EDN1	PN	MPPA
	EDN1	PN	PTGIS
	EDN1	PN	PTHLH
	EDN1	PN	SRC
	EDN1	PN	src family
	EDN1	PN	SST
	EDNRB	PN	AVP
	effector caspase	PN	PARP1
	EGF	PN	APP
	EGF	PN	AREG
	EGF	PN	cANP
	EGF	PN	CAT
	EGF	PN	DAB2
	EGF	PN	DUSP1
	EGF	PN	EPS15
	EGF	PN	FGF2
	EGF	PN	fibroblast growth factor
	EGF	PN	FST
	EGF	PN	GDI
	EGF	PN	GJA1
	EGF	PN	TNHBA
	EGF	PN	MAP2K2
	EGF	PN	MAP3K1
	EGF	PN	MAPK14
	EGF	PN	PLAU
	EGF	PN	PLAUR
	EGF	PN	PRL
	EGF	PN	PTEN
	EGF	PN	RAC1
	EGF	PN	TERF21P
	EGF	PN	THBS1
	EGFR	PN	catemin
	EGFR	PN	CAN1
	EGFR	PN	DNN1
	EGFR	PN	TGF1R
	EGFR	PN	MAPK14
	EGFR	PN	RAS small nonomeric
			GTPase
	EGFR	PN	SHC3
	EGR1	PN	B-cell receptor
	EGR1	PN	JAK2
	EGR1	PN	PPARG
	EGR1	PN	TP53
	EGTA	PN	SYK
	ELA2	PN	CCL2
	ELA2	PN	NNP9
	ELA2	PN	PI3
	ELN	PN	NNP2
	ELN	PN	NNP9
	endothelin	PN	GKRH1
	endothelin	PN	NSN3
	endothelin	PN	NPPA
	endothelin	PN	RAF1
	endothelin-	PN	EDN1
	converting enzyme

	TABLE 16
	Protein A	Protein B
	endotoxin	PN	PTGIS
	EP300	PN	CTNNB1
	EP300	PN	IL6
	EP300	PN	IRF1
	EP300	PN	NDY2
	EP300	PN	NYOD1
	EP300	PN	PCKA
	EP300	PN	SNAD3
	EPHB1	PN	PXN
	EPO	PN	CISH
	EPO	PN	F2
	EPO	PN	PTPN6
	EPOR	PN	PTPN6
	EPSI5	PN	SNAP25
	EPX	PN	JAK2
	EPX	PN	JUN
	EPX	PN	PRKCA
	EPX	PN	SRC
	ERBB2	PN	CSK
	ERBB2	PN	EP300
	ERBB2	PN	PPARG
	ERBB2	PN	RAF1
	ERBB3	PN	AKT1
	ERK activator	PN	MAP2K6
	kinase
	ESR1	PN	CREB1
	estradiol	PN	EGF
	estradiol	PN	LEP
	estradiol	PN	TGFA
	estrogen	PN	AGT
	ETS1	PN	JUN
	ETS1	PN	HYP1
	ETS1	PN	PDGFA
	ETS1	PN	TGFB1
	F10	PN	LCP1
	F2	PN	OTR
	F2	PN	EGFR
	F2	PN	FN1
	F2	PN	IFNG
	F2	PN	MAPK1
	F2	PN	PRKOD
	F2	PN	PTK2
	F2R	PN	map kinase
	F2R	PN	RPS6K
	F2R	PN	SRC
	F3	PN	FI0
	F3	PN	MAPK3
	F7	PN	IL8
	fatty acids	PN	cANP-dependent protein
			kinase. catalyst
	fatty acids	PN	GCG
	fatty acids	PN	LEP
	fatty acids	PN	PPARA
	FcgamaRI	PN	SYK
	Fe(ii)	PN	CAT
	Fe(iii)	PN	HYOX1
	FGF1	PN	EGF
	FGF1	PN	IL1
	FGF1	PN	SIOOA13
	FGF1	PN	STAT3
	FGF2	PN	AKT1
	FGF2	PN	ALB
	FGF2	PN	CKCL12
	FGF2	PN	F2R
	FGF2	PN	FYN
	FGF2	PN	GJA1
	FGF2	PN	LCP1
	FGF2	PN	LPA
	FGF2	PN	MAPK1
	FGF2	PN	SERPIHE1
	FGF2	PN	SST

	TABLE 17
	Protein A	Protein B
	FGFR2	PN	GAP43
	fibrin	PN	LCP1
	fibrin	PN	PLG
	fibrinogen	PN	IL1F8
	fibrinogen	PN	PTGIS
	fibrinogen	PN	TNF
	fibroblast growth	PN	NYP1
	factor
	fibroblast growth	PN	NYP3
	factor
	fibroblast growth	PN	PRV1
	fator
	fibroblast growth	PN	SST
	factor
	FLT1	PN	Phosphatidylinositol
			3-kinase
	FLT1	PN	PTK2B
	FLT4	PN	FGF2
	FN1	PN	fibrinogen
	FN1	PN	GRB2
	FN1	PN	LCP1
	FN1	PN	MAPK3
	FN1	PH	MAPK8
	FN1	PH	NMP14
	FN1	PN	NMP2
	FN1	PN	RAF1
	FOSL2	PN	REL6
	FOXA2	PN	HXF4A
	FOXA2	PN	TCF1
	FOXO1A	PN	HYOD1
	FUT7	PN	HAID1
	GAI7	PN	IL6
	GAB1	PN	RPS6K
	GAB2	PN	AKT1
	GABAA receptor	PN	OXT
	GAL	PN	SST
	GAP	PN	RAC1
	GAPD	PN	BCL2
	GAS	PN	GCG
	GAS	PN	MAPK1
	GAS	PN	MAPK3
	GAS	PN	NNP9
	GAS	PN	HTS
	GAS	PN	ODC1
	GAS	PN	SST
	GAS6	PN	AKL
	GAS6	PN	STAT3
	GATA1	PN	GATA4
	GC6	PN	INS
	GC6	PN	SST
	GDHF	PN	AKT1
	gelatin	PN	NNP2
	gelatin	PN	NNP3
	GFAP	PN	ITIH4
	GH1	PN	CISH
	GH1	PN	GH1
	GH1	PN	SOCS3
	GH1	PN	SST
	GH1	PN	TERF2TP
	GH1	PN	TNF
	GH1	PN	TP53
	GHR	PN	IGF1
	GHR	PN	SOCS3
	GHRH	PN	INS
	GHRH	PN	SST
	GHRL	PN	GHRL
	GHRL	PN	IGF1
	GIP	PN	GCG
	GIP	PN	INS
	GIP	PN	SST
	GLI3	PN	GLI2
	glucan 1,4-	PN	INS
	alpha-glucosidase

	TABLE 18
	Protein A	Protein B
	glucose	PN	BDK
	glucose	PN	FRAP1
	glucose	PN	IGF1
	glucose	PN	LEP
	glucose	PN	MAP2K1
	glucose	PN	MAP3K1
	glucose	PN	MAPK3
	glucose	PN	PRKC0
	glucose	PN	SST
	GLUL	PN	JUN
	GNA12	PN	ARHGEF12
	GNA12	PN	BCL2
	GNA12	PN	JUK
	GNA13	PN	BCL2
	GNA13	PN	CDC42
	GNA13	PN	JUN
	GNA14	PN	SRC
	GNA0	PN	MAP2K6
	GNA0	PN	PLCB1
	GNLY	PN	GCG
	GNRH1	PN	CREB1
	GNRH1	PN	CRH
	GNRH1	PN	MAPK3
	GNRH1	PN	POYC
	GNRH1	PN	PRL
	GNRHR	PN	ADCY2
	GPX1	PN	NOS2A
	GRB2	PN	HRAS
	GRIP1	PN	JUN
	GRLF1	PN	HRAS
	GRLF1	PN	RAF1
	growth factor	PN	ABL1
	activity
	GRP	PN	SST
	GRP	PN	YIP
	GSK3B	PN	MAPK1
	GSN	PN	CFL1
	GTF2B	PN	TBPL1
	GTP	PN	CDC42
	GTP	PN	GHAO
	GTP	PN	HRAS
	GTPase	PN	PAK1
	guanine nucleotide	PN	CDC42
	exchange factor
	GZY8	PN	BCL2
	H1F0	PN	PLG
	H2O2	PN	AKT1
	H2O2	PN	ATV
	H2O2	PN	CYCS
	H2O2	PN	FGF2
	H2O2	PN	MAP2K1
	H2O2	PN	NGFB
	H2O2	PN	PRKCD
	H2O2	PN	PTK2
	H2O2	PN	TXK2
	HDL	PN	APOB
	home	PN	HYOX1
	home	PN	HSPCA
	home oxygenase	PN	CAV1
	(decyclizing)
	HGF	PN	APP
	HGF	PN	MAP2K1
	HGF	PN	MAPK14
	HGF	PN	MAPK3
	HGF	PN	MAPK8
	HGF	PN	RAC1
	HGF	PN	RAF1
	HIF1A	PN	NOS2A
	HIF1A	PN	VEGF
	histanine receptor	PN	AGT
	histone deacetylase	PN	ABCB1
	histone deacetylase	PN	CCNE1
	HLA-A	PN	CD8A
	HYGB1	PN	IL1F8
	HYOK1	PN	HSPA4
	HOYDI3	PN	ODC1

	TABLE 19
	Protein A	Protein B
	HRAS	PN	AKT1
	HRAS	PN	MAPK1
	HRAS	PN	MAPK3
	HSF1	PN	HSPCA
	HSPCA	PN	DCND1
	HSPCB	PN	TP53
	HTATIP	PN	PTGIS
	HTATIP	PN	RAF1
	HTR2A	PN	PONC
	HTR2A	PN	PRL
	hypoxia-inducible	PN	EPX
	factor 1
	hypoxia-inducible	PN	KOS2A
	factor 1
	ICAN1	PN	CD4
	ICAN1	PN	MAPK3
	ICAN1	PN	RAF1
	ICAN1	PN	IFAP2A
	ICOS	PN	IL5
	ICOS	PN	TNF
	IFI16	PN	TP53
	IFNA1	PN	CISH
	IFNA1	PN	IL10
	IFNG	PN	COKN1A
	IFNG	PN	COKN16
	IFNG	PN	CISH
	IFNG	PN	HA
	IFNG	PN	HGF
	IFNG	PN	IFNB1
	IFNG	PN	INDO
	IFNG	PN	JAK
	IFNG	PN	KLRC1
	IFNG	PN	LANR1
	IFNG	PN	LCP1
	IFNG	PN	MAP2K4
	IFNG	PN	MAPK1
	IFNG	PN	MAPK3
	IFNG	PN	NO
	IFNG	PN	Nuclear factor NF
			kappa B
	IFNG	PN	PKA
	IFNG	PN	PKC
	IFNG	PN	prostaglandin
	IFNG	PN	RAC1
	IFNG	PN	SOCS1
	IFNG	PN	SOCS3
	IFNG	PN	SST
	IFNG	PN	testosterone
	IGBP1	PN	BCL2
	IGF1	PN	AKT1
	TGF1	PN	BDK
	IGF1	PN	EGLAP
	IGF1	PN	FN1
	IGF1	PN	GJA1
	IGF1	PN	PRKCE
	IGF1	PN	STAT3
	IGF1	PN	STAT5A
	IGF1R	PN	PKN
	IGF1R	PN	STAT3
	IGF1R	PN	TNF
	IGF1R	PN	TP53
	IGF1R	PN	tumor necrosis factor
	TGF2	PN	IGFBP3
	IGF2	PN	IGFB1
	IGFBP3	PN	AGT
	IGFBP3	PN	SERPINE1
	IGFBP5	PN	IGF3P6
	THH	PN	PTHLH
	IkappaB kinase	PN	MAPK3
	IL1	PN	AVP
	IL1	PN	CHUK
	IL1	PN	IFNB1
	IL1	PN	IL1R1
	IL1	PN	MAPK3
	IL1	PN	MAPK9
	IL1	PN	PTGIS
	IL1	PN	SST
	IL1	PN	TNFRSFIA
	IL1	PN	VGAK1

	TABLE 20
	Protein A	Protein B
	IL10	PN	CISH
	IL10	PN	INHBA
	IL10	PN	SOCS3
	IL10	PN	STAT3
	IL10	PN	THBS1
	IL10	PN	TNFRSF1A
	IL11	PN	IFNG
	IL11	PN	IL4
	IL11	PN	TNFRSF11B
	IL15	PN	IL7
	IL17	PN	CSF3
	IL17	PN	IL4
	IL18	PN	IL4
	IL18	PN	VCAN1
	IL1A	PN	IFNB1
	IL1A	PN	IL10
	IL1A	PN	PONC
	IL1A	PN	PRL
	IL1A	PN	TGFB1
	IL1A	PN	TNFRSF11B
	IL1B	PN	BCL2
	IL1B	PN	CALCA
	IL1B	PN	GH1
	IL1B	PN	HTATIP
	IL1B	PN	ICAN1
	IL1B	PN	IL13
	IL1B	PN	IL4
	IL1B	PN	MAP2K1
	IL1B	PN	MAP2K6
	IL1B	PN	HHP1
	IL1B	PN	HHP3
	IL1B	PN	NPPA
	IL1B	PN	OSH
	IL1B	PN	PONC
	IL1B	PN	SELE
	IL1B	PN	SPP1
	IL1B	PN	TGFB1
	IL1B	PN	TNFRSF11B
	IL1B	PN	VCAN1
	IL1F8	PN	APP
	IL1F8	PN	COKN1A
	IL1F8	PN	CSF3
	IL1F8	PN	IL10
	IL1F8	PN	IL1R1
	IL1F8	PN	MAP2K1
	IL1F8	PN	NNP3
	IL1F8	PN	NNP9
	IL1F8	PN	OSH
	IL1F8	PN	PPARG
	IL1F8	PN	PSYD9
	IL1F8	PN	SNAD3
	IL1F8	PN	SPP1
	IL1F8	PN	TINP1
	IL2	PN	BCL2
	IL2	PN	CISH
	IL2	PN	HSPA4
	IL2	PN	TFNA1
	IL2	PN	IL2RA
	IL2	PN	JUNB
	IL2	PN	LCK
	IL2	PN	NNP2
	IL2	PN	PTGIS
	IL2	PN	RBL2
	IL2	PN	SOCS3
	IL2	PN	TNFRSF6
	IL2	PN	TP53
	IL21	PN	BCL2
	IL2R6	PN	IL4
	IL2R6	PN	IL7
	IL3	PN	STAT5A
	IL3	PN	TGFB1

	TABLE 21
	Protein A		Protein B
	IL4	PN	AKT1
	IL4	PN	CISH
	IL4	PN	JAK1
	IL4	PN	JAK2
	IL4	PN	MAPK1
	IL4	PN	NFKBI
	IL4	PN	PPARG
	IL4	PN	PPPIR136
	IL4	PN	RAF1
	IL4	PN	SOCS3
	IL4	PN	STAT5A
	IL4	PN	TNFRSF1A
	IL4R	PN	interleukin IL13
			receptor
	IL5	PN	CISH
	IL5	PN	HRAS
	IL5	PN	IL10
	IL5	PN	MAPK1
	IL6	PN	APO8
	IL6	PN	AYP
	IL6	PN	BCL2
	IL6	PN	BMP6
	IL6	PN	BYP7
	IL6	PN	CO59
	IL6	PN	CISH
	IL6	PN	HDL
	IL6	PN	ILEST
	IL6	PN	interleukin-6 receptor
	IL6	PN	nap kinase
	IL6	PN	NVP9
	IL6	PN	NFKBI
	IL6	PN	PIAS1
	IL6	PN	PIAS3
	IL6	PN	RAF1
	IL6	PN	RPS6K
	IL6	PN	SHOC2
	IL6	PN	STL1
	IL6	PN	SOCS1
	IL6	PN	SOCS2
	IL6	PN	SOCS3
	IL6	PN	SST
	IL6	PN	TNF-alpha receptor
	IL6	PN	VIP
	IL7	PN	IFNG
	IL7	PN	IL6
	IL8	PN	BCL2
	IL8	PN	IL1R1
	IL8	PN	NFKBIA
	IL8	PN	RHOA
	IL9	PN	CISH
	IL9	PN	IFNG
	IL9	PN	SOCS3
	IL9	PN	STAT5A
	ILF	PN	SOCS3
	ILK	PN	NAFK1
	INHBA	PN	INS
	INHBA	PN	MAPK14
	INHBA	PN	MAPK3
	inositol	PN	ADCY2
	phospholipids
	INS	PN	ABL1
	INS	PN	ADRA1A
	INS	PN	adrenoceptor
	INS	PN	AGT
	INS	PN	AGIR2
	INS	PN	amylase
	INS	PN	APOA1
	INS	PN	CALCA
	INS	PN	CRH
	INS	PN	CRYAB
	INS	PN	DNH1
	INS	PN	DUSP1
	INS	PN	FOS
	INS	PN	GNAD
	INS	PN	GRB14
	INS	PN	GSK38
	INS	PN	HSPCA
	INS	PN	IAPP
	INS	PN	IGFBP3
	INS	PN	IL1

	TABLE 22
	Protein A		Protein B
	INS	PN	INPP50
	INS	PN	INPPL1
	INS	PN	JUN
	INS	PN	LEP
	INS	PN	MAPK11
	INS	PN	MYC
	INS	PN	NFKBIA
	INS	PN	NOS3
	INS	PN	OGT
	INS	PN	opioid receptor
	INS	PN	PDE3B
	INS	PN	PIK3R1
	INS	PN	PIK3R2
	INS	PN	PPARA
	INS	PN	PRKCD
	INS	PN	progesterone
	INS	PN	PTP16
	INS	PN	PTPRF
	INS	PN	RAB4A
	INS	PN	RAC1
	INS	PN	RAPGEF1
	INS	PN	RHOO
	INS	PN	SCN10A
	INS	PN	SERPINE1
	INS	PN	SGK
	INS	PN	SOCS3
	INS	PN	SOCS6
	INS	PN	SP1
	INS	PN	SST
	INS	PN	TAT
	INS	PN	TNFRSF6
	INS	PN	TP53INP1
	INS	PN	TREP10
	INS	PN	TSC1
	INS	PN	VANP2
	INS	PN	VANP3
	insulin receptor	PN	AKT1
	insulin receptor	PN	ERS1
	insulin receptor	PN	KLK3
	insulin receptor	PN	SOCS3
	integrin	PN	F3
	integrin	PN	MAPK3
	interleukin IL12	PN	IL13
	interleukin IL12	PN	IL4
	interleukin IL12	PN	MAPK1
	interleukin IL12	PN	MAPK8
	interleukin IL12	PN	IL10
	receptor
	interleukin IL23	PN	IFNG
	interleukin-1	PN	IFNG
	receptor ligand
	interleukin-1	PN	VCAY1
	receptor ligand
	LOGAP1	PN	RAC1
	IRF1	PN	IRF2
	IRS1	PN	AKT1
	IRS1	PN	PPP1R138
	IRS1	PN	RPS6KB1
	IRS2	PN	AKT1
	IRS2	PN	FRAP1
	isoproterenol	PN	GCG
	ITGB1	PN	SREBF1
	ITIH4	PN	CCL5
	ITIHA	PN	MAPK14
	JVL	PN	CDKN1A
	JAK	PN	SOCS3
	JAK2	PN	CISH
	JAK2	PN	IFNA1
	JAK2	PN	MAPK8
	JAK2	PN	PRKC0
	JAK3	PN	JAK2

	TABLE 23
	Protein A		Protein B
	JAK	PN	DUSP1
	JUN	PN	CEBPG
	JUN	PN	OKK1
	JUN	PN	EBP
	JUN	PN	GSK3B
	JUN	PN	NR4A1
	JUN	PN	Phosphatidylinositol
			3-kinase
	JUN	PN	RARA
	JUN	PN	SO02
	JUN	PN	SP11
	JUK8	PN	NPPA
	KDR	PN	AKT1
	KDR	PN	CAV1
	KDR	PN	HSPCA
	KDR	PN	TGFB1
	kininogenase	PN	BDK
	KIT	PN	BCL2L1
	KIT	PN	MYC
	KITLG	PN	AKT1
	KITLG	PN	BCL2L1
	KITLG	PN	CISH
	KITLG	PN	IL8
	KITLG	PN	LYN
	KITLG	PN	SRC
	KLK3	PN	A2Y
	KLRA1	PN	NIC8
	KRAS2	PN	AKT1
	LAN	PN	IL10
	laminin	PN	NYP2
	laminin	PN	PLAU
	laminin	PN	PONC
	LBP	PN	CD14
	LCK	PN	MAPK1
	LCP1	PN	A2Y
	LCP1	PN	MP3
	LCP2	PN	PLCG1
	LDL	PN	ALB
	LDL	PN	YAPK14
	LDL	PN	RHOA
	LDL	PN	SELE
	LEP	PN	CISH
	LEP	PN	POYC
	LEP	PN	SOCS3
	LEP	PN	STAT3
	LEP	PN	TGFB1
	LGALS1	PN	PTPRC
	LIF	PN	CISH
	LIF	PN	MAPK8
	linoleic acid	PN	EGFR
	lipid	PN	PPARA
	Lipids	PN	AKT1
	Lipopolysaccharide	PN	IL10
	LOC365454	PN	RAC1
	LPA	PN	CAT
	LPA	PN	DTR
	LPA	PN	EGFR
	LPA	PN	GAB1
	LPA	PN	PLG
	LPA	PN	PTPN11
	LPL	PN	LDLR
	LPL	PN	PRL
	LPS	PN	HTATIP
	LPS	PN	IFNA1
	LPS	PN	IFNG
	LPS	PN	IL10
	LPS	PN	IL6
	LPS	PN	MAPK9
	LPS	PN	SPP1
	LPS	PN	TGFB1
	LRBA	PN	TP53
	LRP1	PN	VEGF
	LTB	PN	PPARA
	LTB4	PN	IL4

	TABLE 24
	Protein A		Protein B
	Luteinizing hormone	PN	IL1B
	LYN	PN	MAP2K7
	LYN	PN	protein phosphatase 1
	MAG-1 (integrin)	PN	CAT
	MADD	PN	TNF
	MAH	PN	CYP2E1
	map kinase	PN	CALCA
	map kinase	PN	CREB1
	map kinase	PN	DUSP1
	map kinase	PN	HSPA4
	map kinase	PN	SELL
	map kinase	PN	SOCS3
	map kinase	PN	TH
	MAP kinase kinase	PN	TERF2IP
	kinase
	MAP2K1	PN	CDG2PN
	MAP2K1	PN	MAPK14
	MAP2K1	PN	MAPK8
	MAP2K1	PN	SNAD2
	MAP2K2	PN	MAPK14
	MAP2K2	PN	MAPK8
	MAP2K3	PN	MAPK1
	MAP3K1	PN	AXT1
	MAP3K1	PN	DUSP1
	MAP3K1	PN	MAP2K4
	MAP3K1	PN	MAPK9
	MAP3K1	PN	THFRSF6
	MAP3K10	PN	MAP2K4
	MAP3K3	PN	CHUK
	MAP3K5	PN	CDC25A
	MAP3K5	PN	TP53
	MAPK1	PN	ADRBK1
	MAPK1	PN	AR
	MAPK1	PN	ATF2
	MAPK1	PN	CASP3
	MAPK1	PN	CDK4
	MAPK1	PN	CISH
	MAPK1	PN	DEFB4
	MAPK1	PN	DUSP1
	MAPK1	PN	DUSP4
	MAPK1	PN	HEF1A
	MAPK1	PN	MLC1
	MAPK1	PN	MYP2
	MAPK1	PN	nadph oxidase
	MAPK1	PN	PLAUR
	MAPK1	PN	protein-glutamine gamre-
			glutanyltransferase
	MAPK1	PN	RPS6
	MAPK1	PN	SOCS1
	MAPK14	PN	CDKH1A
	MAPK14	PN	HSPA4
	MAPK14	PN	nadph oxidase
	MAPK14	PN	NOS3
	MAPK14	PN	NPPA
	MAPK14	PN	PPARA
	MAPK14	PN	PPARG
	MAPK14	PN	SWD3
	MAPK3	PN	CDKN1B
	MAPK3	PN	dual-specificity
			protein phosphatase
	MAPK3	PN	FOSB
	MAPK3	PN	GAB1
	MAPK3	PN	MAPKAP1
	MAPK3	PN	MCF1
	MAPK3	PN	PRKCE
	MAPK3	PN	PTGS2
	MAPK3	PN	SAP kinase
	MAPK7	PN	MAP2K2
	MAPK7	PN	MAPK3

	TABLE 25
	Protein A		Protein B
	MAPK8	PN	CAT
	MAPK8	PN	CDKN1A
	MAPK8	PN	DUSP1
	MAPK8	PN	HSP81
	MAPK8	PN	IkappaB kinase
	MAPK8	PN	JKK
	MAPK8	PN	MPPB
	MAPK8	PN	PARP1
	MAPK8	PN	PKC
	MAPK8	PN	PPN1L
	MAPK8	PN	protein phosphatase 2A
	MAPK8	PN	SYAD2
	MAPK8	PN	SYCA
	MAPK8	PN	SOD2
	MAPK8	PN	ATF2
	MAPK9	PN	SCL2L1
	MAPK9	PN	MAPK8
	MAPK9	PN	SNAD4
	MAPKAP1	PN	OX1
	matrix	PN	P2
	metalloproteinase
	MAX	PN	NXI1
	MCF2	PN	CDC42
	MCF2	PN	MAPK1
	MCF2L	PN	CDC42
	MCN7	PN	NC2
	MCP	PN	TGFB1
	MDA	PN	CAT
	MDK2	PN	E2F1
	MDK2	PN	HIF1A
	MDK2	PN	MDH4
	MEN1	PN	RUNX2
	MET	PN	PRL
	MIF	PN	src family
	MITF	PN	MAPK14
	MKNK1	PN	EIF4EBP1
	MLN	PN	INS
	MNP13	PN	TINP1
	MYP14	PN	VEGF
	MYP2	PN	map kinase
	MYP2	PN	PTK2
	MYP2	PN	TINP1
	MYP3	PN	FGF7
	MYP3	PN	JUN
	MYP3	PN	TIYP1
	MOS	PN	RPS6K
	MSIB	PN	EGFR
	MSTI	PN	DFFA
	MTBP	PN	IP53
	MUC4	PN	SNAD2
	MYC	PN	CD2A
	MYC	PN	GAPD
	NYC	PN	GATA1
	NYC	PN	histone
	NYC	PN	KRT18
	NYC	PN	NFKB1A
	NYC	PN	NSEP1
	NYC	PN	phosphopyruvate
			hydratase
	NYC	PN	TFAP2A
	NYCN	PN	NGFB
	NYOD1	PN	TGFB1
	NCF1	PN	MAPK1
	NCSTN	PN	APP
	nerve growth factor	PN	TP53
	receptor ligand
	NF-kappeB-inducing	PN	MAPK8
	kinase
	NFKBIA	PN	RELA
	NFKBIA	PN	SRC
	NSFB	PN	AKT1
	NGFB	PN	EGR1
	NGFB	PN	IFNG
	NGFB	PN	LIF
	NGFB	PN	MAPK8
	NGFB	PN	PLAUR
	NGFB	PN	PPP1R13B
	NGFB	PN	RAC1
	NGFB	PN	TP53

	TABLE 26
	Protein A		Protein B
	NID	PN	NKP3
	nitric oxide	PN	SRC
	synthase
	NDA receptor	PN	PARP1
	NNK	PN	CγP2E1
	NNK	PN	PTGS1
	NO	PN	BCL2
	NO	PN	BCL2L1
	NO	PN	GCG
	NO	PN	GNRH1
	NO	PN	HRAS
	NO	PN	IL10
	NO	PN	SPP1
	NO	PN	TP53
	noradrenaline	PN	AVP
	norapinephrine	PN	APP
	NOS1	PN	PTGS2
	NOS2A	PN	HNGB1
	NOS2A	PN	IL1R1
	NOS2A	PN	JUN
	NOS2A	PN	NFNB1A
	NOS2A	PN	TP53
	NOS3	PN	SRC
	NOTCH3	PN	VAPK1
	NPY	PN	CRH
	NROB1	PN	NR5A1
	NR3C1	PN	BCL2L1
	NR3C1	PN	HSPCA
	NR3C1	PN	KY3
	NR3C1	PN	NFKBIA
	NR5A2	PN	NROB2
	NRG1	PN	NAPK14
	NTS	PN	DRD2
	NTS	PN	SST
	NUCB2	PN	PPARA
	Nuclear factor NF	PN	AHR
	kappa B
	Nuclear factor NF	PN	CISH
	kappa B
	Nuclear factor NF	PN	EBP
	kappa B
	Nuclear factor NF	PN	EGR1
	kappa B
	Nuclear factor NF	PN	F3
	kappa B
	Nuclear factor NF	PN	FOS
	kappa B
	Nuclear factor NF	PN	HYOX1
	kappa B
	Nuclear factor NF	PN	IRF1
	kappa B
	Nuclear factor NF	PN	NYC
	kappa B
	Nuclear factor NF	PN	NOS2A
	kappa B
	Nuclear factor NF	PN	REL
	kappa B
	okadaic acid	PN	IL1R1
	opioid receptor	PN	NAPK1
	OSN	PN	CDKN1A
	OSN	PN	STAT3
	OXT	PN	POYC
	oxygen	PN	BOL2L1
	oxygen	PN	SELP
	Oxysterols	PN	CAT
	PAH	PN	CYP1A1
	PAK2	PN	ABL1
	PARP1	PN	CASP7
	PARP1	PN	CDKN1A
	PARP1	PN	NAPK1

	TABLE 27
	Protein A		Protein B
	pathway-specific	PN	JUN
	SYAD protein
	pathway-specific	PN	NAPK8
	SYAD protein
	pathway-specific	PN	SYAD2
	SYAD protein
	PAKR	PN	CASP8
	PAKR	PN	YAPK1
	PAKR	PN	RAF1
	PAKR	PN	TNFRSF6
	PAX6	PN	INS
	PC4	PN	CDKN1B
	PCNA	PN	CDKN1A
	PDCD8	PN	DIABL0
	PDE40	PN	NAPK1
	PDGFA	PN	NAP2K1
	PDGFRB	PN	PLCG1
	pentagastrin	PN	CCK
	peptide receptor,	PN	CXCL12
	G-protein coupled
	peptide receptor,	PN	CKCR3
	G-protein coupled
	peptide receptor,	PN	RAC1
	G-protein coupled
	PF4	PN	IL8
	PGE1	PN	IL10
	PGE1	PN	IL4
	PGE1	PN	PRL
	PGE2	PN	BNP2
	PGE2	PN	GH1
	PGE2	PN	IL1R1
	PGE2	PN	NPPA
	PGF	PN	BHOA
	PGF2 alpha	PN	PRL
	phenylephrine	PN	NPPA
	phosphatidylcholine	PN	CCL21
	phosphatidylcholine	PN	F2
	Phosphatidylinositol	PN	F3
	3-kinas
	Phosphatidylinositol	PN	CTSB
	3-kinase
	Phosphatidylinositol	PN	EIF4E
	3-kinase
	Phosphatidylinositol	PN	EPHA3
	3-kinase
	Phosphatidylinositol	PN	HIF1A
	3-kinase
	Phosphatidylinositol	PN	YDK2
	3-kinase
	Phosphatidylinositol	PN	NEF2A
	3-kinase
	Phosphatidylinositol	PN	PIPN11
	3-kinase
	phosphoinositide	PN	GRP58
	PI	PN	NSHB
	PIK3CA	PN	AKT1
	PIK3CA	PN	PPP1R13B
	PIK3CG	PN	RAC1
	PIK3R1	PN	Phosphatidylinositol
			3-kinase
	PIN1	PN	STAT5A
	PKA	PN	AKT1
	PKA	PN	HRAS
	PKA	PN	HSFB1
	PKA	PN	IGF1
	PKA	PN	NFKB1A
	PKC	PN	DUSP1
	PKC	PN	EIF4EBP1
	PKC	PN	NET
	PKC	PN	NPPA
	PKC	PN	RB1
	PKC	PN	SELP
	PKC	PN	SRC
	PLA2G2D	PN	NAPK1

	TABLE 28
	Protein A		Protein B
	PLAT	PN	LPA
	PLAT	PN	PLG
	PLAT	PN	SERPINE1
	platelet-derived	PN	ADCY2
	growth factor
	platelet-derived	PN	ENP2
	growth factor
	platelet-derived	PN	CAT
	growth factor
	platelet-derived	PN	DUSP1
	growth factor
	platelet-derived	PN	GJA1
	growth factor
	platelet-derived	PN	KLK3
	growth factor
	platelet-derived	PN	NAP3K11
	growth factor
	platelet-derived	PN	NAPK3
	growth factor
	platelet-derived	PN	NYC
	growth factor
	platelet-derived	PN	NGFB
	growth factor
	platelet-derived	PN	PPARG
	growth factor
	platelet-derived	PN	PTGIS
	growth factor
	platelet-derived	PN	PTPN11
	growth factor
	platelet-derived	PN	RAC1
	growth factor
	platelet-derived	PN	RAF1
	growth factor
	platelet-derived	PN	TXN
	growth factor
	platelet-derived	PN	EDN1
	growth factor
	platelet-derived	PN	NPPA
	growth factor
	platelet-derived	PN	VEGF
	growth factor
	PLAU	PN	NYP3
	PLAU	PN	PLAT
	PLAU	PN	SRC
	PLAUR	PN	SERPINE1
	PLCG1	PN	GSN
	PLCG1	PN	PRKCN
	PLCG1	PN	profilin
	PLG	PN	ELA2
	PNA	PN	ADCY2
	PNA	PN	ADN
	PNA	PN	CCND1
	PNA	PN	DTR
	PNA	PN	OUSP1
	PNA	PN	ESR1
	PNA	PN	NAP3K1
	PNA	PN	NAPK1
	PNA	PN	NAPK3
	PNA	PN	YYC
	PNA	PN	NPPA
	PNA	PN	PAK1
	PNA	PN	RAF1
	PNA	PN	SST
	PHCH	PN	GNA0
	PNL	PN	TP53
	porin	PN	BCL2L1
	PPARG	PN	EGF
	PPARG	PN	IRF1
	PPARG	PN	NAPK1
	PPARG	PN	NAPK3
	PPARG	PN	NAPK3
	PPARG	PN	TGFB1
	PRKCA	PN	TP53
	PRKCE	PN	calcium
	PRKCE	PN	nap kinase
	PRKCE	PN	RPSGK
	PRKCZ	PN	RPSGKB1
	PRKDC	PN	TP53

	TABLE 29
	Protein A		Protein B
	PRL	PN	AKT1
	PRL	PN	CESH
	PRL	PN	IFKG
	PRL	PN	IGF2
	PRL	PN	JUN
	PRL	PN	LIF
	PRL	PN	NOS2A
	PRL	PN	TNF
	progesterone	PN	DUSP1
	progesterone	PN	GNRH1
	progesterone	PN	HYGCR
	progesterone	PN	LEP
	prostaglandin	PN	EGFR
	prostaglandin	PN	POEC
	prostaglandin	PN	PRL
	prostaglandin-	PN	VIP
	endoperox de synthase
	protein C	PN	F2R
	(activated)
	protein phosphatase	PN	F2
	protein phosphatase	PN	IL6
	protein	PN	RAF1
	phosphatase 1
	protein	PN	RB1
	phosphatase 1
	protein	PN	SP1
	phosphatase 2A
	protein tyrosine	PN	BCL2L1
	kinase
	protein tyrosine	PN	BDK
	kinase
	protein tyrosine	PN	CBL
	kinase
	protein tyrosine	PN	RS1
	kinase
	protein tyrosine	PN	NPPA
	kinase
	protein tyrosine	PN	PTK28
	kinase
	protein tyrosine	PN	SOCS3
	kinase
	protein tyrosine	PN	NYC
	kinase
	protein tyrosine	PN	PXN
	phosphatase
	PSD	PN	RAC1
	PSEN1	PN	APP
	PSYD9	PN	Cyp2b20
	PTEN	PN	FOX01A
	PTEN	PN	oxygen
	PTGDS	PN	PPARG
	PTGER1	PN	IL1B
	PTGIS	PN	IL10
	PTGS1	PN	PTGS2
	PTGS2	PN	IL4
	PTGS2	PN	NFKBIA
	PTGS2	PN	PPARA
	PTGS2	PN	PTGIS
	PTH	PN	IL18
	PTHLH	PN	EGFR
	PTHLH	PN	PTH
	PTHR1	PN	IGF1
	PTK2	PN	BCAR1
	PTK2	PN	CASP3
	PTK2	PN	CASP3
	PTK2	PN	NAPK3
	PTK2	PN	PTEN
	PTK2	PN	PTPN11
	PTK2	PN	PKH
	PTK2B	PN	RHOA
	PTP4A3	PN	JAK2
	PTPRA	PN	SRC
	PTPRC	PN	STAT6
	PTTGI	PN	TP53

	TABLE 30
	Protein A		Protein B
	quinone	PN	TP53
	RA	PN	CYP1A1
	RAC1	PN	COH1
	RAC1	PN	map kinase
	RAC1	PN	VAP3K1
	RAC1	PN	NAPK14
	RAC1	PN	NNP2
	RAC1	PN	RHOA
	RAC1	PN	SAP kinase
	RAF1	PN	BRAF
	RAF1	PN	RPSGKB1
	RALGDS	PN	STAT3
	RAPGEF1	PN	RAF1
	RARA	PN	IGFBP3
	RAS small monomeric	PN	CCHD1
	GTPase
	RAS small monomeric	PN	CDKN2A
	GTPase
	RAS small monomeric	PN	E2F1
	GTPase
	RAS small monomeric	PN	VAP2K6
	GTPase
	RAS small monomeric	PN	VAPK14
	GTPase
	RAS small monomeric	PN	PAK1
	GTPase
	RAS small monomeric	PN	PPPIR13B
	GTPase
	RAS small monomeric	PN	TRAF3
	GTPase
	RASA1	PN	GRLF1
	RASD1	PN	NAPK3
	RB1	PN	CDKN1A
	RB1	PN	COKN1B
	RB1	PN	SP1
	RB1	PN	TGFB2
	RBL1	PN	CCND1
	RBL1	PN	CDKN1A
	RBL2	PN	CCNE1
	receptor signaling	PN	AKT1
	protein
	receptor tyrosine	PN	PTPN6
	kinase
	REL	PN	BCL2L1
	REL	PN	RELB
	RELA	PN	EP300
	RELB	PN	NFKBIA
	REH	PN	ARG2
	REN	PN	NPY
	RET	PN	AKT1
	RETN	PN	AKT1
	RETN	PN	EDN1
	RGS2	PN	IL2
	RHO	PN	JUN
	RHO	PN	GRK1
	Rho small monomeric	PN	CDCA2
	GTPase
	Rho small monomeric	PN	NAPK8
	GTPase
	Rho small monomeric	PN	PTK2
	GTPase
	Rho small monomeric	PN	RAC1
	GTPase
	Rho small monomeric	PN	RHOA
	GTPase
	RHOA	PN	geranylgeranyl
			pyrophosphate
	RHOA	PN	map kinase
	RHOA	PN	NAPK1
	RHOA	PN	NKL1
	RHOA	PN	NYOD1
	RHOA	PN	oxygen
	RHOA	PN	PAKG
	RHOA	PN	PCLD
	RHOA	PN	RAF1
	RHOA	PN	TNC
	RIPK1	PN	MAP3K1
	RIPK2	PN	MAPK1
	RIPK2	PN	MAPK3

	TABLE 31
	Protein A		Protein B
	RPS6K	PN	CALCA
	RPS6K	PN	CREB1
	RPS6K	PN	DUSP1
	RPS6K	PN	EIF4E
	RPS6K	PN	HSPA4
	RPS6K	PN	SELL
	RPS6K	PN	TERF21P
	RPS6K	PN	TH
	RPS6K81	PN	MAPKS
	RRAS	PN	HRAS
	RRAS	PN	PTK2
	RRAS	PN	RAF1
	RUNX2	PN	TNFSF11
	SI00B	PN	IFN6
	SIP	PN	RAC1
	SAP kinase	PN	BCL2
	SAP kinase	PN	DUSP1
	SAP kinase	PN	IL6
	SAP kinase	PN	IL8
	SCARB1	PN	CAV1
	SCLY	PN	CSF2
	SCT	PN	INS
	SELE	PN	STAT6
	SELL	PN	MAPK8
	SELPLG	PN	PKC
	SERPINE1	PN	MAPK3
	SERPINE2	PN	F2R
	SHC1	PN	MAPK3
	SHC1	PN	PTEN
	SHH	PN	BHP2
	SLC12A9	PN	RB1
	SLC2A4	PN	SLC2A1
	SLJT2	PN	CXCL12
	SMAD1	PN	SMAD4
	SMAD3	PN	ESR1
	SMAD3	PN	JUN
	SMAD3	PN	MAP3K1
	SMAD3	PN	NR3C1
	SMAD3	PN	SMAD7
	SMAD3	PN	MDR
	SKAD4	PN	MAPK3
	SMAD5	PN	SMAD9
	small numeric	PN	RAF1
	GTPase
	SMAP	PN	MAPK1
	SOD2	PN	PGE2
	SP1	PN	CC2D1
	SP1	PN	ILIF8
	SP1	PN	IRF1
	SP1	PN	MUC2
	SP1	PN	THFRSF6
	SP1	PN	TP53
	sphingosine-1-	PN	TGF81
	phosohate phosphatase
	SPN	PN	TNF
	SPP1	PN	MAPK1
	SRC	PN	ADRBK1
	SRC	PN	ATF2
	SRC	PN	CAV1
	SRC	PN	CCL21
	SRC	PN	GRB2
	SRC	PN	HRAS
	SRC	PN	MAP2K2
	SRC	PN	NYP2
	SRC	PN	NYP9
	SRC	PN	PLAUR
	src family	PN	GAV1
	src family	PN	CBL
	src family	PN	HRAS
	src family	PN	LYN
	src family	PN	MAPK9
	src family	PN	PLAUR
	SREBF1	PN	HYGCR
	SREBF1	PN	LDLR
	SREBF1	PN	LEP
	SRF	PN	IER2
	SST	PN	CDC25C
	SST	PN	IL2
	SSTR2	PN	PTPN11
	SSTR2	PN	PTPN6

	TABLE 32
	Protein A		Protein B
	STAT3	PN	CISH
	STAT3	PN	JUN
	STAT3	PN	SOCS3
	STAT5A	PN	ESR1
	STAT5B	PN	SOCS3
	STAT6	PN	IFN6
	steroid receptor	PN	PGR
	STNN1	PN	TP53
	STX4A	PN	F2
	superoxide cisutase	PN	INS
	SYK	PN	MPK3
	T-cell transcription	PN	GSK3B
	factor NFATC
	T-cell transcription	PN	MAPK8
	factor NFATC
	TBP	PN	TP53
	TCE	PN	CYP1A1
	TCE	PN	CYP2E1
	TCE	PN	Cyp3a11
	T-cell receptor	PN	CBLB
	T3 complex
	T-cell receptor	PN	JUN
	T3 complex
	T-cell receptor	PN	MAP2K1
	T3 complex
	T-cell receptor	PN	MAP3K1
	T3 complex
	T-cell receptor	PN	RAC1
	T3 complex
	TCF1	PN	ALB
	TDE1	PN	CASP9
	telomerase	PN	MAPK1
	testosterone	PN	CYP19A1
	testosterone	PN	TAC1
	testosterone	PN	TGFB1
	TFDP1	PN	E2F1
	TFF3	PN	MAPK1
	TFRC	PN	TF
	TG	PN	IL1B
	TGFB1	PN	activin
	TGFB1	PN	BGN
	TGFB1	PN	COL21
	TGFB1	PN	CTF1
	TGFB1	PN	DPT
	TGFB1	PN	FST
	TGFB1	PN	HYAL2
	TGFB1	PN	IGFBP2
	TGFB1	PN	IGFBP5
	TGFB1	PN	IL7
	TGFB1	PN	inhibitory SMAD protein
	TGFB1	PN	KLRC1
	TGFB1	PN	LAMA1
	TGFB1	PN	LOK
	TGFB1	PN	LPA sodium sell
	TGFB1	PN	MAP2K4
	TGFB1	PN	NF1
	TGFB1	PN	NPPB
	TGFB1	PN	PGE1
	TGFB1	PN	PLAS4
	TGFB1	PN	PKG
	TGFB1	PN	PLA2G1B
	TGFB1	PN	PLAUR
	TGFB1	PN	PPARA
	TGFB1	PN	procollagen
			N-endopeptidase
	TGFB1	PN	RA
	TGFB1	PN	RAC1
	TGFB1	PN	REL
	TGFB1	PN	SERPINE1
	TGFB1	PN	SHADG
	TGFB1	PN	SMAD7
	TGFB1	PN	THBS2
	TGFBR1	PN	SMAD3
	THBD	PN	PROC
	THBS1	PN	MNP2
	THP0	PN	STAT1
	THP0	PN	STAT3
	THP0	PN	TNF

	TABLE 33
	Protein A		Protein B
	thrombin	PN	DTR
	thrombin	PN	EGFR
	thrombin	PN	FN1
	thrombin	PN	PRKOD
	thrombin	PN	PRKCE
	thrombin	PN	PTGTS
	thrombin	PN	PTK2
	thrombin	PN	SERPINE1
	thyroid stimulating	PN	STAT3
	hormone
	TIKP1	PN	MAPK14
	TLR4	PN	IL10
	TLR4	PN	IL6
	TLR4	PN	TNF
	TNA	PN	PLG
	TNC	PN	HYP13
	TNF	PN	ADH
	TNF	PN	ANXA1
	TNF	PN	ATF3
	TNF	PN	BCL2A1
	TNF	PN	BCL2L1
	TNF	PN	BCL3
	TNF	PN	CD4
	TNF	PN	CD80
	TNF	PN	CD8A
	TNF	PN	CHUX
	TNF	PN	CTNNB1
	TNF	PN	CXCL9
	TNF	PN	DUSP1
	TNF	PN	E2
	TNF	PN	E2F1
	TNF	PN	exo-alpha-sialidase
	TNF	PN	ferritin
	TNF	PN	FGF2
	TNF	PN	HDL
	TNF	PN	HIF1A
	TNF	PN	HRAS
	TNF	PN	IFNB1
	TNF	PN	Ikappa B
	TNF	PN	ILIORA
	TNF	PN	IL11
	TNF	PN	IL9
	TNF	PN	IRF1
	TNF	PN	ITGA4
	TNF	PN	LEF
	TNF	PN	LFA-1 (integrin)
	TNF	PN	MAP2K1
	TNF	PN	MAP2K2
	TNF	PN	MAP2K4
	TNF	PN	MAP3K1
	TNF	PN	MAP3K5
	TNF	PN	MAP3K3
	TNF	PN	HSK1
	TNF	PN	ND
	TNF	PN	NR3C1
	TNF	PN	PDGFA
	TNF	PN	P13
	TNF	PN	PPARA
	TNF	PN	PRKCI
	TNF	PN	protein tyrosine kinase
			inhibitor
	TNF	PN	PTGS2
	TNF	PN	RAC1
	TNF	PN	RHOA
	TNF	PN	SAP kinase
	TNF	PN	SERPING1
	TNF	PN	SHAD1
	TNF	PN	SOCS1
	TNF	PN	SOD1
	TNF	PN	SOD2
	TNF	PN	SPHK1
	TNF	PN	STAT1
	TNF	PN	STAT6
	TNF	PN	superoxide dismutase
	TNF	PN	TLR2
	TNF	PN	TNFRSF1A
	TNF	PN	TRAD0
	TNF	PN	TRAF1
	TNF	PN	TRAF4
	TNF	PN	TXN
	TNF	PN	VIP
	TNF	PN	ZFP36

	TABLE 34
	Protein A		Protein B
	TNFATPB	PN	NFKBIA
	TNF-alpha receptor	PN	NFKBIA
	TNFRSF108	PN	CASP10
	TNFRSF1A	PN	CASP3
	TNFRSF1A	PN	VAPK14
	TNFRSF5	PN	CD86
	TNFRSF5	PN	STAT6
	TNFRSF6	PN	OOKNIA
	TNFRSF6	PN	IL10
	TNFRSF6	PN	IL3
	TNFRSF6	PN	NAPK14
	TNFRSF6	PN	BAPK9
	TNFRSF6	PN	NFKB1
	TNFRSF6	PN	PPARA
	TNFRSF6	PN	RAC1
	TNFRSF10	PN	BCL2
	TNFRSF10	PN	BCL2L1
	TNFRSF10	PN	CYCS
	TNFRSF10	PN	EGF
	TNFRSF10	PN	NAPK1
	TNFRSF10	PN	NFKBIA
	TNFRSF10	PN	PARP1
	TNFRSF10	PN	TKF
	TNFRSF11	PN	HFKBIA
	TNFRSF4	PN	IL4
	TNFRSF5	PN	IL10
	TNFRSF5	PN	NAPK1
	TNFRSF5	PN	TNFSF11
	TNFRSF6	PN	NFK61
	Toll receptor	PN	BCL2
	TP53	PN	CASP2
	TP53	PN	CASP8
	TP53	PN	ESR1
	TP53	PN	HAPK1
	TP53	PN	HDN2
	TP53	PN	NET
	TP53	PN	PEG3
	TP53	PN	PPH1D
	TP53	PN	PYCR1
	TP53	PN	SFH
	TP53	PN	MT1
	TP73	PN	CCG1
	TP73	PN	EDX2
	TRAF2	PN	GCXR
	TRAF2	PN	HAP3K1
	TRAF2	PN	TNFRSF1A
	TRAF3	PN	KFIBIA
	TRAF3	PN	TNFRSF5
	TRAF6	PN	NAPK14
	TRAF6	PN	TRAF3
	transcription	PN	BOL2L11
	factor
	transcription	PN	PONG
	factor	PN
	transcription	PN	PPARG
	factor	PN
	transforming	PN	COKN1A
	growth factor	PN
	TSG1	PN	TSC2
	TTF1	PN	TG

	TABLE 35
	Protein A		Protein B
	tumor necrosis	PN	BCL2L1
	factor
	tumor necrosis	PN	HGF
	factor
	tumor necrosis	PN	OX1
	factor
	tumor necrosis	PN	IRS1
	factor
	tumor necrosis	PN	LIF
	factor
	tumor necrosis	PN	NOS2A
	factor
	tumor necrosis	PN	PONC
	factor
	tumor necrosis	PN	PTGS2
	factor
	tumor necrosis	PN	REL
	factor
	tumor necrosis	PN	S0D2
	factor
	tumor necrosis	PN	SST
	factor
	tumor necrosis	PN	STAT6
	factor
	tumor necrosis	PN	VCAK1
	factor
	tumor necrosis	PN	IL13
	factor
	UBL3	PN	TGFB1
	yesopressin	PN	AVP
	VAV1	PN	CBL
	VAV1	PN	CDC42
	VAV1	PN	PAK1
	VAV1	PN	RAC1
	VAV2	PN	CDC42
	VAV2	PN	RAC1
	VAV3	PN	STAT3
	VCAN1	PN	PTK2
	VCAN1	PN	RAC1
	VDR	PN	TTGAN
	VEGF	PN	FLT1
	VEGF	PN	LCP1
	VEGF	PN	PTK2
	VEGF	PN	PTK2B
	VEGF	PN	RAC1
	VEGF	PN	SELE
	VIP	PN	GALGA
	VIP	PN	GCG
	VIP	PN	SST
	VLDL	PN	LEP
	voltage-dependent	PN	GN
	calcium channel
	VTN	PN	FN1
	VTN	PN	SERPINE1
	water	PN	NPPA
	T1	PN	NRDB1
	ZAP70	PN	PTPK6
	ZAP148	PN	TP53

	TABLE 36
	Protein A		Protein B
	A2Y	PP	TGFB1
	ABL1	PP	H2O2
	ABL1	PP	HCK
	ABL1	PP	integrin
	ABL1	PP	HCK1
	ABL1	PP	PRKCD
	ABL1	PP	src family
	ABL1	PP	TP73
	ACDC	PP	INS
	acetyltransferase	PP	INS
	ADAKTSL1	PP	TGFB1
	ADCY2	PP	FOS
	ADCY2	PP	MAPK3
	ADCY2	PP	PONC
	ADCYAP1	PP	ADCY2
	ADCYAP1	PP	TAC1
	ADORA2A	PP	MAPKS
	ADP	PP	JUN
	ADP	PP	MAPK8
	ADP	PP	P2RY1
	ADRBK1	PP	RAS small monomeric
			GTPase
	AGT	PP	EDN1
	AGT	PP	EGF
	AGT	PP	HRAS
	AGT	PP	MAPK3
	AGT	PP	Phosphatidylinositol
			3-kinase
	AGT	PP	PLCG1
	AGT	PP	TKF
	AGT	PP	VEGF
	AGTR1	PP	ANG
	AGTR1	PP	IGF1
	AGTR1	PP	SERPINE1
	AKR1B1	PP	TNF
	AKT1	PP	ADP
	AKT1	PP	calcium-dependent cell
			adhesion molecule
	AKT1	PP	catenin
	AKT1	PP	CDC37
	AKT1	PP	CDKN1A
	AKT1	PP	CREB1
	AKT1	PP	CSF1
	AKT1	PP	CSF2
	AKT1	PP	CTGF
	AKT1	PP	EGF
	AKT1	PP	estrogen
	AKT1	PP	F2
	AKT1	PP	GSK3A
	AKT1	PP	HGF
	AKT1	PP	IFNG
	AKT1	PP	IGF1R
	AKT1	PP	IgG
	AKT1	PP	IL5
	AKT1	PP	IL8RB
	AKT1	PP	LK
	AKT1	PP	RS
	AKT1	PP	insulins
	AKT1	PP	integrin
	AKT1	PP	JAK2
	AKT1	PP	laminio
	AKT1	PP	LEP
	AKT1	PP	lipid
	AKT1	PP	MSK1
	AKT1	PP	MYOD1
	AKT1	PP	NPPA
	AKT1	PP	Nuclear factor NF
			kappa B
	AKT1	PP	OR2C1
	AKT1	PP	PAK1
	AKT1	PP	peptide receptor,
			G-protein coupled
	AKT1	PP	progesterone
	AKT1	PP	protein serine/
			theronine kinase
	AKT1	PP	PS
	AKT1	PP	PtdIns-3. 4-P 2
	AKT1	PP	RAS small monomeric
			GTPase
	AKT1	PP	RELA

	TABLE 37
	Protein A		Protein B
	AKT1	PP	SLC2A1
	AKT1	PP	SSTR2
	AKT1	PP	THPO
	AKT1	PP	transmembrane receptor
			protein tyrosine kinase
	AKT1	PP	tumor necrosis factor
	AKT1	PP	UCN
	AKT1	PP	UCN3
	AKT2	PP	NYOD1
	ALB	PP	CAV1
	ALK	PP	IPN1
	ALOK5	PP	TNF
	APAF1	PP	TP53
	APP	PP	IL18
	APP	PP	STAT3
	APP	PP	THF
	APP	PP	THFRSF5
	AR	PP	EP300
	AR	PP	SRC
	AR	PP	STAT5A
	ARAF1	PP	EDK1
	ARAF1	PP	MAP2K1
	ARAF1	PP	MAP2K2
	ARAF1	PP	MAPK1
	ARAF1	PP	RAS small monomeric
			GTPase
	AREG	PP	BT1
	ARF1P2	PP	RAC1
	ARG2	PP	TGFB1
	ARHGEF12	PP	GNA13
	ARRB1	PP	MAPK3
	ATF2	PP	TGFB1
	AYP	PP	ADCY2
	BAX	PP	BCL2L2
	BAX	PP	CASP3
	BAX	PP	TNFRSF6
	BBC3	PP	TP53
	BCAR1	PP	CRK
	BCAR1	PP	EGF
	BCAR1	PP	FN1
	BCAR1	PP	NS
	BCAR1	PP	KRAS2
	BCAR1	PP	YAPK8
	BCAR1	PP	SRC
	B-cell receptor	PP	JUN
	BCL2	PP	cAYP-dependent protein
			kinase.
	BCL2	PP	Phosphatidylinositol
			3-kinase
	BCL2	PP	POU4F1
	BCL2	PP	RPS6K
	BCL2	PP	STAT3
	BCL2	PP	TNFRSF17
	BCL2	PP	VEGF
	BCL2L1	PP	STAT3
	BCL3	PP	CCND1
	BDK	PP	EGFR
	BDK	PP	IL18
	BDK	PP	IL1F8
	BDK	PP	NGF8
	BDK	PP	PRKCE
	BDK	PP	PTGS2
	BDK	PP	TAC1
	BDNF	PP	CREB1
	BDNF	PP	FGF2
	BDNF	PP	PIPN11
	BDNF	PP	VIP
	BIRC3	PP	NAPK8
	BKP2	PP	BCL2L1
	BRAF	PP	MAP2K1
	BRAF	PP	MAP2K2
	BRAF	PP	MAPK1
	BRAF	PP	MAPK3
	BRAF	PP	NTRK1
	BRAF	PP	RASGRP1
	BRAF	PP	RPS6K
	BRAF	PP	T-cell receptor
			T3 complex
	BRAF	PP	TERF2IP
	BRCA1	PP	IFNG

	TABLE 38
	Protein A		Protein B
	BTK	PP	LYN
	C5R1	PP	IL6
	CALCA	PP	ADCY2
	CALCA	PP	GCG
	CALCA	PP	TGFB1
	calcium	PP	PLCG1
	calcium-dependent	PP	RAC1
	cell adhesion molecule
	calmodulin	PP	EGFR
	calpain	PP	EGF
	CaN-kinase II	PP	EGF
	cANP	PP	EGFR
	cAKP-dependent	PP	ADH
	protein kinase.
	catalyst
	CAPG	PP	PLCG1
	casein	PP	INS
	CASP6	PP	TP53
	CASP8	PP	BAX
	CASP8	PP	CASP9
	CASP8	PP	GYCS
	CASP8	PP	TNFSF6
	CASP9	PP	CASP3
	CASP9	PP	effector caspase
	CASP9	PP	PARP1
	CASP9	PP	PTK2
	CASP9	PP	TNFRSF6
	caspase	PP	CDKN1A
	caspase	PP	MAPK3
	catecholamine	PP	Na+/K+ ATPase
	CAV1	PP	CAV2
	CAV1	PP	IL6
	CBL	PP	EGF
	CBL	PP	FH1
	CBL	PP	INS
	CBL	PP	KDR
	CBL	PP	Phosphatidylinositol
			3-kinase
	CCL2	PP	IL1A
	CCL2	PP	IL3
	CCL2	PP	IL6
	CCL2	PP	JUN
	CCL2	PP	MAPK3
	CCL2	PP	TNF
	CCL21	PP	cANP
	CCL4	PP	TNF
	CCL5	PP	TFNG
	CCL5	PP	MAPK14
	CCKA2	PP	TP53
	CCHD1	PP	CDK6
	CCHD1	PP	CDKN1A
	CCHD1	PP	EGF
	CCHD1	PP	ERBB2
	CCHD1	PP	MAP2K1
	CCHD1	PP	MAPK1
	CCHD1	PP	NYC
	CCHD1	PP	PCAF
	CCHD1	PP	platelet-derived
			growth factor
	CCHD1	PP	RAF1
	CCHD1	PP	RBL2
	CCKH	PP	CAK complex
	CD28	PP	JUN
	CD28	PP	MAPK8
	CD4	PP	IL4
	CD4	PP	IL6
	CD44	PP	HGF
	CD44	PP	TGFB1
	CD48	PP	TFNG
	CD5	PP	NAFK8
	CD58	PP	IL4
	CDC2	PP	CDC25C
	CDC25A	PP	CCNE1
	CDC25C	PP	NSLN
	CDC42	PP	F2
	CDC42	PP	PTK2
	CDC42	PP	RAF1

	TABLE 39
	Protein A		Protein B
	CDH1	PP	NYC
	CDK2	PP	OCND2
	CDKN1A	PP	ERCA1
	CDKN1A	PP	EGF
	CDKN1A	PP	EGFR
	CDKN1A	PP	FGF2
	CDKN1A	PP	HDKA10
	CDKN1A	PP	nap kinase
	CDKN1A	PP	MAPK1
	CDKN1A	PP	HTRK1
	CDKN1A	PP	Nuclear factor NF
			kappa 8
	CDKN1A	PP	PAK1
	CDKN1A	PP	Phosphatidylinositol
			3-kinase
	CDKN1A	PP	PKC
	CDKN1A	PP	PRKCA
	CDKN1A	PP	protein serine/
			threonine kinase
	CDKN1A	PP	protein tyrosine kinase
	CDKN1A	PP	SLC12A9
	CDKN1A	PP	STAT1
	CDKN1A	PP	TP73
	CDKN1B	PP	CDKN1A
	CDKN1B	PP	CDKN1C
	CDKN1B	PP	JUN
	CDKN1B	PP	NYOD1
	CDKN1B	PP	SP1
	CDKN2B	PP	TGFB1
	CEBPA	PP	USF1
	CEBFB	PP	RAS small monomeric
			GTPase
	CEBPB	PP	STAT3
	CEBPB	PP	transcription factor
	CEBPG	PP	IL6
	choline phosphatase	PP	PRKCZ
	choline phosphatase	PP	RHOA
	CHUK	PP	1KBKB
	CHUK	PP	NF-kappa8-inducing
			kinase
	CNTF	PP	IL6
	CNTF	PP	NAPK1
	CNTF	PP	NAPK3
	CREB1	PP	ADCY2
	CREB1	PP	EP300
	CREB1	PP	GC6
	CREB1	PP	IL2
	CREB1	PP	NAPK14
	CREB1	PP	POKC
	CREB1	PP	RAC1
	CREB1	PP	SRC
	CREB1	PP	TGFB1
	CRH	PP	ILG
	CRH	PP	TNF
	CRHR1	PP	MAPK3
	CRK	PP	DOCK1
	CRK	PP	EGF
	CRK	PP	NAPK1
	CRK	PP	NGFB
	CRK	PP	platelet-derived
			growth factor
	CRK	PP	PKN
	CRK	PP	RAS small monomeric
			GTPase
	CRK	PP	RPS6K
	CRK	PP	src family
	CRK	PP	T-cell receptor
			T3 complex
	CRKL	PP	EGF
	CRKL	PP	RAPGEF1
	CSF1	PP	CCL2
	CSF1	PP	CSF2
	CSF1	PP	IL6
	CSF1	PP	NAPK1
	CSF1	PP	STAT3

	TABLE 40
	Protein A		Protein B
	CSF2	PP	IL2
	CSF2	PP	JAK2
	CSF2	PP	JUN
	CSF2	PP	KITL6
	CSF2	PP	LYN
	CSF2	PP	NAPK14
	CSF2	PP	PTPN11
	CSF2	PP	RAF1
	CSF2	PP	STAT5A
	CSF2	PP	TNF
	CSF2	PP	VEGF
	CSF3	PP	CEBPB
	CSF3	PP	CISH
	CSF3	PP	CSF3R
	CSF3	PP	IL1
	CSF3	PP	IL6
	CSF3	PP	ITGA11
	CSF3	PP	ITGAX
	CSF3	PP	ITGB2
	CSF3	PP	JAK1
	CSF3	PP	JAK2
	CSF3	PP	LYN
	CSF3	PP	RAF1
	CSF3	PP	RPS6K
	CSF3	PP	STAT1
	CSF3	PP	TYK2
	CTGF	PP	FH1
	CTGF	PP	TGFB1
	CTGF	PP	VEGF
	CTNNB1	PP	LEF
	CTNNB1	PP	LEF1
	CX3CL1	PP	TP53
	CXCL10	PP	CXCR3
	CXCL5	PP	TNF
	CXCL9	PP	IFNG
	CXCR3	PP	VAPK1
	cyclin	PP	E2F1
	CYCS	PP	CASP9
	CYCS	PP	effector caspase
	CYP1A1	PP	CYP2B6
	diacylglycerol	PP	PLC61
	DTR	PP	NAPK1
	E2F1	PP	CASP9
	E2F1	PP	caspase
	E2F1	PP	CHEK2
	EDN1	PP	CKCL1
	EDN1	PP	EGF
	EDN1	PP	HRAS
	EDN1	PP	YAPK3
	EDN1	PP	NOS2A
	EDN1	PP	PLA2618
	EDN1	PP	RHOA
	EDN1	PP	SHC1
	EDN1	PP	VEGF
	EEF2X	PP	FRAP1
	EGF	PP	ABL1
	EGF	PP	adrenoceptor
	EGF	PP	AGTR1
	EGF	PP	ALB
	EGF	PP	ARF6
	EGF	PP	CDC42
	EGF	PP	CISH
	EGF	PP	DNN1
	EGF	PP	DTR
	EGF	PP	ELK1
	EGF	PP	ERBE3
	EGF	PP	ERK activator kinase
	EGF	PP	FN1
	EGF	PP	FOS
	EGF	PP	GAB1
	EGF	PP	GH1
	EGF	PP	K202
	EGF	PP	IGF1
	EGF	PP	IL6
	EGF	PP	NAP2K1
	EGF	PP	NAPK3
	EGF	PP	NYC
	EGF	PP	PTK2
	EGF	PP	PTPN11
	EGF	PP	RAF1

	TABLE 41
	Protein A		Protein B
	EGF	PP	SHC1
	EGF	PP	SRC
	EGF	PP	STAT3
	EGF	PP	TGFA
	EGFR	PP	AREG
	EGFR	PP	DTR
	EGFR	PP	EPS15
	EGFR	PP	ERBB4
	EGFR	PP	FN1
	EGFR	PP	GAB1
	EGFR	PP	nap kinase
	EGFR	PP	NAPK3
	EGFR	PP	NAP2
	EGFR	PP	Nuclear factor NF
			kappa B
	EGFR	PP	PGE2
	EGFR	PP	PKC
	EGFR	PP	PLCG1
	EGFR	PP	PTK2
	EGFR	PP	PTK28
	EGFR	PP	SOS1
	EGFR	PP	SRC
	EGFR	PP	TGFB1
	EGFR	PP	UBE2L3
	EGR1	PP	FGF2
	EGR1	PP	IGF2
	EGR1	PP	IL3
	EGR1	PP	interleukin-1 receptor
			ligand
	EGR1	PP	NTSR1
	EGR1	PP	PDGFA
	EGR1	PP	platelet-derived
			growth factor
	EGR1	PP	RPSGK
	EGR1	PP	TGFB1
	EGR1	PP	TNF
	ELF3	PP	ERBB2
	ELK1	PP	JUN
	ELK1	PP	HAPK3
	ELK1	PP	HAPK8
	ELK1	PP	P2RY1
	ELK1	PP	SAP kinase
	endothelin	PP	IL6
	EKTPD2	PP	EGF
	EP300	PP	TGFB1
	EPHA3	PP	VEGF
	EPHB1	PP	HAPK1
	EPHB1	PP	HAPK8
	EPX	PP	CSF3
	ERBB2	PP	GRE2
	ERBB2	PP	Nuclear factor NF
			kappa B
	ERB32	PP	PTGS2
	ERB84	PP	ERBB2
	ERK activator kinase	PP	HAPK8
	ESR1	PP	AKT2
	ESR1	PP	JUN
	ESR1	PP	HAPK1
	ESR1	PP	SP1
	ETS1	PP	COLIA2
	ETS1	PP	ETS2
	ETS1	PP	PPARA
	ETS1	PP	VEGF
	ETS2	PP	CGHD1
	ETY1	PP	ERBB2
	F2	PP	ICAH1
	F2	PP	HAPK3
	F2	PP	Phosphatidylinositol
			3-kinase
	F2	PP	PLAUR
	F2	PP	PLCG1
	F2	PP	PRKCA
	F2	PP	protein phosphatase 1
	F2	PP	PTK2B
	F2	PP	SHC1

	TABLE 42
	Protein A		Protein B
	F2R	PP	ACRBK2
	F2R	PP	beta-n-
			acetylglucoseninidase
	F2R	PP	EGF
	F2R	PP	ICAN1
	F2R	PP	peptide receptor,
			G-protein coupled
	F2R	PP	Phosphatidylinositol
			3-kinase
	F2R	PP	PLAT
	F2R	PP	RAP1B
	F2R	PP	SELP
	F2R	PP	SHC1
	F2R	PP	TXNL5
	F2RL1	PP	F2R
	F2RL1	PP	peptide receptor,
			G-protein coupled
	F2RL1	PP	phospholipase C
	F3	PP	ALB
	F3	PP	F2
	F3	PP	IL18
	FCER2	PP	IL6
	Ferritin	PP	IFNG
	FGF1	PP	Hap kinase
	FGF1	PP	NGFB
	FGF1	PP	PLK3
	FGF1	PP	RPS6K
	FGF18	PP	ERK activator kinase
	FGF2	PP	BCL2L1
	FGF2	PP	CD44
	FGF2	PP	JUN
	FGF2	PP	NPPA
	FGF2	PP	PLOG1
	FGF2	PP	PRL
	FGF2	PP	PTGS2
	FGF2	PP	PTPH11
	FGF2	PP	TGFB1
	FGF2	PP	VEGF
	FGF7	PP	HAPK1
	fibroblast growth	PP	TNF
	factor
	FN1	PP	AGT
	FN1	PP	EDN1
	FN1	PP	HAP2K1
	FN1	PP	HAPK1
	FN1	PP	HAP9
	FN1	PP	PTK2
	FN1	PP	RHOA
	FN1	PP	VEGF
	FOS	PP	AGT
	FOS	PP	BDNF
	FOS	PP	CREB1
	FOS	PP	ELK1
	FOS	PP	JUNB
	FOS	PP	VAPK8
	FOS	PP	ODC1
	FOS	PP	RAF1
	FOS	PP	RPSGKB1
	FOS	PP	SRG
	FOS	PP	STAT3
	FOSB	PP	JUN
	FYN	PP	ELK1
	FYN	PP	PLCG1
	g protein	PP	EGFR
	GA17	PP	TFNG
	GAB1	PP	HGF
	GAB1	PP	nap kinase
	GAB1	PP	Phosphatidylinositol
			3-kinase
	GAB1	PP	platelet-derived
			growth factor
	GADD45A	PP	COKN1A
	GADD45A	PP	NAPK8
	GAP	PP	NAPK1
	GAS	PP	THF

	TABLE 43
	Protein A		Protein B
	GCG	PP	ADCY2
	GCG	PP	NAP2K1
	GCG	PP	NAPK1
	GCG	PP	NAPK3
	GCG	PP	PONC
	GDNF	PP	HAPK1
	GEF	PP	RAC1
	GH1	PP	CEBP3
	GH1	PP	GNRH1
	GH1	PP	IRS1
	GH1	PP	JAK2
	GJAI	PP	NAPK3
	GLI	PP	GLI2
	glucose	PP	PPARGC1A
	glutamate receptor	PP	NAPK1
	GNA12	PP	NAPK3
	GNAO	PP	RHOA
	GNRH1	PP	ADCYAP1
	GNRH1	PP	EGFR
	GNRHR	PP	EGFR
	GNRHR	PP	NAPK1
	GRB2	PP	BCR
	GRB2	PP	EGF
	GRB2	PP	LPA
	GRB2	PP	SHC1
	Group] cetabotropic	PP	NAPK3
	glutamate receptor	PP	JUN
	growth factor
	receptor	PP	BCL2L11
	GSK3B
	GSK3B	PP	BDNF
	GSK3B	PP	NAP2K1
	GTPase	PP	GNAO
	guanine nucleotide	PP	RAC1
	exchange factor
	GYPC	PP	IL6
	H+/K+ ATPase	PP	AKT1
	H2O2	PP	POGFB
	H2O2	PP	PLGG1
	HAND1	PP	IFNG
	HGF	PP	IL6
	HGF	PP	NGFB
	HGF	PP	NOS2A
	HGF	PP	PLAU
	HGF	PP	PLAUR
	HGF	PP	PTPH11
	HGF	PP	SP1
	HGF	PP	SRC
	HGF	PP	VEGF
	HGS	PP	EGF
	HIFIA	PP	GSK38
	HLA-A	PP	IFNG
	HNOX1	PP	IL6
	HNOX1	PP	NAPK14
	HNOX1	PP	NAPK3
	HRAS	PP	EGFR
	HRAS	PP	KRT18
	HRAS	PP	PLC61
	HSPA4	PP	HSPCA
	HSPB2	PP	TNF
	HSPCA	PP	NOS3
	HSPCA	PP	STAT3
	HSFCA	PP	VEGF
	HSPE1	PP	HSPD1
	HTATIP	PP	IL6
	ICAN1	PP	CCL5
	ICAN1	PP	FOS
	ICAN1	PP	IL2
	ICAN1	PP	HAPK8
	ICAN1	PP	STAT1
	IER2	PP	JUN
	IER2	PP	INF

	TABLE 44
	Protein A		Protein B
	IFNG	PP	B2H
	IFNG	PP	B7H3
	IFNG	PP	GASP1
	IFNG	PP	CCR5
	IFNG	PP	CCR6
	IFNG	PP	CD69
	IFNG	PP	CD86
	IFNG	PP	COK5R1
	IFNG	PP	CEACAY5
	IFNG	PP	CK3CL1
	IFNG	PP	CKCL16
	IFNG	PP	DPP4
	IFNG	PP	FCGR1A
	IFNG	PP	HLA-B
	IFNG	PP	HLA-E
	IFNG	PP	HSPA4
	IFNG	PP	IL15
	IFNG	PP	IL-18 receptor
	IFNG	PP	IL1F8
	IFNG	PP	IL2RB
	IFNG	PP	IRF1
	IFNG	PP	JAK2
	IFNG	PP	LTA
	IFNG	PP	LY96
	IFNG	PP	neopterin
	IFNG	PP	NOS2A
	IFNG	PP	OAS1
	IFNG	PP	PIH1
	IFNG	PP	PLA2618
	IFNG	PP	RA
	IFNG	PP	RPS6K
	IFNG	PP	SELL
	IFNG	PP	SFTPA1
	IFNG	PP	SNN2
	IFNG	PP	STAT3
	IFNG	PP	STAT5A
	IFNG	PP	TACR1
	IFNG	PP	TBK21
	IFNG	PP	TKFRSF6
	IFKG	PP	TRIY8
	IGBPI	PP	CCND1
	IGF1	PP	BCL2
	IGF1	PP	BDNF
	IGF1	PP	CCNA2
	IGF1	PP	CRK
	IGF1	PP	EGFR
	IGF1	PP	FOS
	IGF1	PP	VAPK3
	IGF1	PP	OXT
	IGF1	PP	POYC
	IGF1	PP	PRL
	IGF1	PP	PTGS2
	IGF1	PP	PTK2
	IGF1	PP	PTPN11
	IGF1	PP	RAF1
	IGF1	PP	SHC1
	IGF1	PP	SRC
	IGF1R	PP	IGF1
	IGFBP3	PP	IP53
	IHH	PP	KAPK3
	IkappaB kinase	PP	CHUK
	IL1	PP	ECR1
	IL1	PP	IFNG
	IL1	PP	IL6
	IL1	PP	YAPK1
	IL10	PP	POYC
	IL13	PP	IL2
	IL13	PP	IL3
	IL13	PP	IL5
	IL17	PP	TNF
	IL18	PP	IFNG

	TABLE 45
	Protein A		Protein B
	IL1A	PP	CGL5
	IL1A	PP	CSF2
	IL1A	PP	CXCL10
	IL1A	PP	F2
	IL1A	PP	FNI
	IL1A	PP	HGF
	IL1A	PP	IL1B
	IL1A	PP	IL1F8
	IL1A	PP	NFKBIA
	IL1A	PP	NGFB
	IL1B	PP	CEBPB
	IL1B	PP	CSF1
	IL1B	PP	CSF2
	IL1B	PP	EDNI
	IL1B	PP	HGF
	IL1B	PP	HSPA4
	IL1B	PP	IL6
	IL1B	PP	KIILG
	IL1B	PP	NAPK1
	IL1B	PP	NAPK14
	IL1B	PP	NAPK3
	IL1B	PP	NAPK8
	IL1B	PP	TAC1
	IL1B	PP	TNFRSF6
	IL1F8	PP	AKT1
	IL1F8	PP	CD44
	IL1F8	PP	EGRI
	IL1F8	PP	FOS
	IL1F8	PP	NAPK14
	IL1F8	PP	TNFRSF5
	IL1F8	PP	VCAN1
	IL2	PP	AKTI
	IL2	PP	CD4
	IL2	PP	CO44
	IL2	PP	CSF1
	IL2	PP	GRB2
	IL2	PP	HRAS
	IL2	PP	IL1B
	IL2	PP	JUN
	IL2	PP	KITLG
	IL2	PP	NAPK1
	IL2	PP	NAPK3
	IL2	PP	PLAUR
	IL2	PP	PLCG1
	IL2	PP	PONC
	IL2	PP	RAF1
	IL2	PP	SHG1
	IL2	PP	STAT5A
	IL2	PP	TNFRSF5
	IL2	PP	TNFSF6
	IL24	PP	IL20RB
	IL3	PP	AKTI
	IL3	PP	CBL
	IL3	PP	CSF2
	IL3	PP	ILIA
	IL3	PP	ILIB
	IL3	PP	IL6
	IL3	PP	JAK2
	IL3	PP	LYN
	IL3	PP	NAPK1
	IL3	PP	NAPK8
	IL3	PP	PTPN11
	IL3	PP	SHG1
	IL4	PP	IRS1
	IL4	PP	NAPK14
	IL4	PP	PLCG1
	IL4	PP	TNFRSF5
	IL4	PP	VCAN1
	IL5	PP	VCAN1
	IL5	PP	ILIB
	IL5	PP	JAK2
	IL5	PP	JUN
	IL5	PP	NAPK3
	IL5	PP	SHC1

	TABLE 46
	Protein A		Protein B
	IL6	PP	A2H
	IL6	PP	ACP1
	IL6	PP	AGT
	IL6	PP	AKT1
	IL6	PP	APP
	IL6	PP	AREG
	IL6	PP	cAMP
	IL6	PP	CD14
	IL6	PP	CEBPD
	IL6	PP	CRP
	IL6	PP	CSF2
	IL6	PP	EBP
	IL6	PP	EDN1
	IL6	PP	ELA2
	IL6	PP	F3
	IL6	PP	FCGR3A
	IL6	PP	FGF7
	IL6	PP	FH1
	IL6	PP	FOS
	IL6	PP	GZMA
	IL6	PP	H2O2
	IL6	PP	hemoglobin
	IL6	PP	histamine
	IL6	PP	HSPB2
	IL6	PP	ICAN1
	IL6	PP	TGF1
	IL6	PP	IL1A
	IL6	PP	IL2
	IL6	PP	IL6R
	IL6	PP	IL8
	IL6	PP	IILH4
	IL6	PP	KIT
	IL6	PP	lactate
	IL6	PP	LIF
	IL6	PP	LTB4
	IL6	PP	MAPK3
	IL6	PP	YHC class II complex
	IL6	PP	YHC class II protein
	IL6	PP	NOS2A
	IL6	PP	PGE1
	IL6	PP	PKG
	IL6	PP	PLA2G10
	IL6	PP	PHA
	IL6	PP	PTGS1
	IL6	PP	PTGS2
	IL6	PP	PTPRC
	IL6	PP	RAS small monomeric
			GTPase
	IL6	PP	SLC12A4
	IL6	PP	STAT1
	IL6	PP	TAC1
	IL6	PP	TNFRSF1A
	IL6	PP	TNFRSF5
	IL6	PP	TNFSF11
	IL6	PP	TRAF3
	IL6	PP	TYK2
	IL6	PP	VEGF
	IL6ST	PP	CDKN1A
	IL8	PP	CEBPB
	IL8	PP	CSF3
	IL8	PP	EDN1
	IL8	PP	EGFR
	IL8	PP	FGF2
	IL8	PP	IL1A
	IL8	PP	MAPK8
	IL8	PP	POYC
	IL8	PP	TAC1
	IL8	PP	TGFA
	IL8	PP	TNFSF6
	IL8	PP	VEGF
	IL8RA	PP	IL8RB
	IL8RB	PP	CXCL1
	ILF	PP	IL8
	ILK	PP	TGFB1
	IHBA	PP	TGFB1
	inositol lipids	PP	AXT1

	TABLE 47
	Protein A		Protein B
	INS	PP	ADRB2
	INS	PP	AIB
	INS	PP	ANXA1
	INS	PP	ARNT
	INS	PP	atypical protein
			kinase C
	INS	PP	calmodulin
	INS	PP	CDC42
	INS	PP	CREB1
	INS	PP	CSF1
	INS	PP	EDN1
	INS	PP	EGF
	INS	PP	EGR1
	INS	PP	estradiol
	INS	PP	FGF1
	INS	PP	fibroblast growth factor
	INS	PP	GAS
	INS	PP	GCXR
	INS	PP	GRB10
	INS	PP	GRB2
	INS	PP	IGF1R
	INS	PP	IGFBP5
	INS	PP	IL1RN
	INS	PP	IP3
	INS	PP	IPF1
	INS	PP	JAK2
	INS	PP	KLK3
	INS	PP	map kinase
	INS	PP	MAPK1
	INS	PP	HIF
	INS	PP	HEK6
	INS	PP	HGF8
	INS	PP	Nuclear factor NF
			kappa B
	INS	PP	ODC1
	INS	PP	OKT
	INS	PP	PDYN
	INS	PP	phospholipase C
	INS	PP	PKC
	INS	PP	PKLR
	INS	PP	platelet-derived
			growth facor
	INS	PP	PCH
	INS	PP	PONG
	INS	PP	PRKCZ
	INS	PP	protein phosphatase
	INS	PP	protein tyrosine kinase
	INS	PP	PTGDS
	INS	PP	PTHLH
	INS	PP	PTPN11
	INS	PP	pyruvate dehydrogenase
	INS	PP	RA
	INS	PP	RAS small monomeric
			GTPase
	INS	PP	RPS6KA3
	INS	PP	SOS1
	INS	PP	SRC
	INS	PP	src family
	INS	PP	TRH
	INS	PP	TUB
	INS	PP	VEGF
	insulin receptor	PP	GAB1
	insulin receptor	PP	SOS1
	insulin receptor	PP	PRKCA
	integrin	PP	FLT1
	integrin	PP	PDGFB
	integrin	PP	RHOA
	interleukin IL12	PP	IFNG
	interleukin IL12	PP	TNF
	interleukin IL12	PP	IFNG
	receptor
	interleukin IL2	PP	BCL2
	receptor
	interleukin IL2	PP	IFNG
	receptor
	interleukin IL2	PP	PTK2B
	receptor
	IRF1	PP	STAT1
	IRF7	PP	MAPK8
	IRS1	PP	PTK2

	TABLE 48
	Protein A		Protein B
	ITK	PP	TGFB1
	JAK1	PP	IFNG
	JAK2	PP	EGFR
	JAK2	PP	IGF1
	JUN	PP	JUN
	JUN	PP	PRKCE
	JUN	PP	ABCB1
	JUN	PP	ABL1
	JUN	PP	AKT1
	JUN	PP	ATF2
	JUN	PP	ATF3
	JUN	PP	CANK2A
	JUN	PP	caspase
	JUN	PP	CNTF
	JUN	PP	EDN1
	JUN	PP	EGFR
	JUN	PP	FH1
	JUN	PP	IL6
	JUN	PP	IL8
	JUN	PP	map kinase
	JUN	PP	MAP2K4
	JUN	PP	MAP3K1
	JUN	PP	MAPK14
	JUN	PP	MET
	JUN	PP	MITF
	JUN	PP	MAP9
	JUN	PP	NFAT
	JUN	PP	NFKB1
	JUN	PP	Nuclear factor NF
			kappa B
	JUN	PP	ODC1
	JUN	PP	PGE2
	JUN	PP	platelet-derived
			growth factor
	JUN	PP	protein serine/
			threonine kinase
	JUN	PP	protein tyrosine kinase
	JUN	PP	RAF1
	JUN	PP	replication factor C
	JUN	PP	RIPK2
	JUN	PP	RPS6K
	JUN	PP	SP1
	JUN	PP	SPP1
	JUN	PP	TNF
	JUN	PP	TNFRSF6
	JUN	PP	tumor necrosis factor
	JUN	PP	VEGF
	JUNB	PP	FOSL1
	JUND	PP	YAPK3
	KDR	PP	IFNG
	KDR	PP	PLOG1
	KITLG	PP	HGF
	KITLG	PP	IL1A
	KITLG	PP	IL3
	KITLG	PP	IL4
	LC	PP	JUN
	LDL	PP	TNF
	LDLR	PP	APOE
	LEF	PP	CCND1
	LEP	PP	CCK
	LEP	PP	EDN1
	LEP	PP	IL16
	LEP	PP	IL1F8
	LEP	PP	IL6
	LEP	PP	LIF
	LEP	PP	MAPK8
	LEP	PP	PRL
	LIF	PP	CEBP8
	LIF	PP	KITLG
	LIF	PP	PRKCD
	LIF	PP	STAT3
	LIF	PP	TNF
	LIP	PP	PTPN11
	LPA	PP	EGF
	LPA	PP	IGF1
	LPA	PP	IL6
	LPA	PP	RHOA
	LPA	PP	SERPINE1
	LPS	PP	MAPK1
	LPS	PP	MAPK3

	TABLE 49
	Protein A		Protein B
	LRPAP1	PP	MAPK1
	LTA	PP	TNF
	LTB	PP	MAPK1
	LTB	PP	TNF
	LYN	PP	B-cell receptor
	LYN	PP	IL5
	LYN	PP	platelet-derived
			growth factor
	LYN	PP	protein tyrosine kinase
	MAD	PP	TGFB1
	map kinase	PP	EGR1
	map kinase	PP	TNF
	map kinase	PP	IFNG
	MAP2K1	PP	IL2
	MAP2K1	PP	IL6
	MAP2K1	PP	JUN
	MAP2K1	PP	PTK2
	MAP2K6	PP	JUN
	MAP2K6	PP	MAPK3
	MAP2K6	PP	MAPK8
	MAP3K1	PP	MAPK2K1
	MAP3K1	PP	MAPK3
	MAP3K1	PP	TP53
	MAP3K11	PP	MAPK1
	MAP3K5	PP	MAPK8
	MAP3K8	PP	MAPK8
	MAPK1	PP	ADAN17
	MAPK1	PP	ADCY2
	MAPK1	PP	ADP
	MAPK1	PP	AGTR1
	MAPK1	PP	ALON12
	MAPK1	PP	CaS-kinase II
	MAPK1	PP	DCL5
	MAPK1	PP	CDKN1B
	MAPK1	PP	CFLAR
	MAPK1	PP	CKCL12
	MAPK1	PP	ELK1
	MAPK1	PP	FPR1
	MAPK1	PP	GJA1
	MAPK1	PP	GRB2
	MAPK1	PP	MAP kinase
	MAPK1	PP	MAPK9
	MAPK1	PP	MP3
	MAPK1	PP	MSK1
	MAPK1	PP	NYDA receptor
	MAPK1	PP	FDPK1
	MAPK1	PP	PKG
	MAPK1	PP	PPARA
	MAPK1	PP	PRKCZ
	MAPK1	PP	protein phosphatase
	MAPK1	PP	PTK2B
	MAPK1	PP	RPS6KA2
	MAPK1	PP	RPS5KA4
	MAPK1	PP	SSTR4
	MAPK1	PP	TERF2IP
	MAPK1	PP	TLR4
	MAPK1	PP	TNFSF11
	MAPK1	PP	tumor necrosis factor
	MAPK14	PP	AGT
	MAPK14	PP	CSF1
	MAPK14	PP	EDN1
	MAPK14	PP	ELA2
	MAPK14	PP	TCAN1
	MAPK14	PP	IL2
	MAPK14	PP	KLG
	MAPK14	PP	NGFB
	MAPK14	PP	PDGFRA
	MAPK14	PP	STAT1
	MAPK14	PP	VEGF

	TABLE 50
	Protein A		Protein B
	MAPK3	PP	AGTR1
	MAPK3	PP	CSF2
	MAPK3	PP	EGR1
	MAPK3	PP	EIF354
	MAPK3	PP	glutamate receptor
	MAPK3	PP	H2O2
	MAPK3	PP	HTATIP
	MAPK3	PP	IL6R
	MAPK3	PP	IL8R8
	MAPK3	PP	insulin receptor
	MAPK3	PP	LRPAP1
	MAPK3	PP	NYP3
	MAPK3	PP	NPPA
	MAPK3	PP	Nuclear factor NF
			kappa 8
	MAPK3	PP	PDEGH
	MAPK3	PP	PKA
	MAPK3	PP	PLA2GIB
	MAPK3	PP	prostaglandin
	MAPK3	PP	protein serine/
			threonine kinase
	MAPK3	PP	RAF1
	MAPK3	PP	RAPGEF1
	MAPK3	PP	RASGRP1
	MAPK3	PP	receptor tyrosine kinase
	MAPK3	PP	RPS6KB1
	MAPK3	PP	TNF
	MAPK3	PP	TNFRSF5
	MAPK3	PP	transcription factor
	MAPK3	PP	tranmembrane receptor
			protein tyrosine kinase
	MAPK3	PP	VEGF
	MAPK8	PP	APP
	MAPK8	PP	B-cell receptor
	MAPK8	PP	CASP3
	MAPK8	PP	CASP8
	MAPK8	PP	CASP9
	MAPK8	PP	CCL5
	MAPK8	PP	CYCS
	MAPK8	PP	DUSP22
	MAPK8	PP	EGFR
	MAPK8	PP	EPHA4
	MAPK8	PP	EPX
	MAPK8	PP	F2
	MAPK8	PP	FADD
	MAPK8	PP	HYOX1
	MAPK8	PP	HTATIP
	MAPK8	PP	IL1F8
	MAPK8	PP	LTB
	MAPK8	PP	nap kinase
	MAPK8	PP	MAP2K7
	MAPK8	PP	MAP3K1
	MAPK8	PP	MAP3K11
	MAPK8	PP	MAP3K2
	MAPK8	PP	MAP3K3
	MAPK8	PP	MAP3K4
	MAPK8	PP	NEDD9
	MAPK8	PP	PGE2
	MAPK8	PP	PIAS1
	MAPK8	PP	platelet-derived
			growth factor
	MAPK8	PP	PTGS2
	MAPK8	PP	PTK23
	MAPK8	PP	RAS small monomeric
			GTPase
	MAPK8	PP	replication factor C
	MAPK8	PP	RHOB
	MAPK8	PP	src family
	MAPK8	PP	telomerase
	MAPK8	PP	transcription factor
	MAPK8	PP	VEGF
	MBP	PP	INS
	MBP	PP	TGFB1
	MCL1	PP	EGFR
	MDH2	PP	ligase
	MDK2	PP	RAS small monomeric
			GTPase

	TABLE 51
	Protein A		Protein B
	MDP	PP	F2R
	MDP	PP	IFKG
	MDP	PP	IL6
	MDP	PP	TNF
	MDP	PP	TNF
	MHP1	PP	IL6
	MHP2	PP	BS6
	MHP2	PP	EPHA1
	MHP2	PP	FGF2
	MHP2	PP	IL1F8
	MHP2	PP	NKP13
	MHP2	PP	NKP14
	MHP2	PP	NKP9
	MHP2	PP	VEGF
	MHP7	PP	EGFR
	MHP9	PP	EGF
	MHP9	PP	IL8
	MHP9	PP	TGF31
	MHP9	PP	TNF
	MHP9	PP	VEGF
	MPO	PP	CSF3
	MYC	PP	PRKCE
	MYC	PP	RAF1
	MYC	PP	TNF
	MYC	PP	TNFSF6
	NBS1	PP	TP53
	NF1	PP	GTPase
	NFKB1	PP	CCHD1
	NGFB	PP	BONF
	NGFB	PP	CREB1
	NGFB	PP	FOS
	NGFB	PP	GAB1
	NGFB	PP	GSK3B
	NGFB	PP	IL3
	NGFB	PP	IL6
	NGFB	PP	NAPK1
	NGFB	PP	NAPK3
	NGFB	PP	PRKCE
	NGFB	PP	PTGS2
	NGFB	PP	TAC1
	NGFR	PP	NAPK3
	NGFR	PP	TP53
	nitric oxide synthase	PP	IFNG
	NO	PP	NAPK1
	NOS2A	PP	JAK2
	NOS2A	PP	NAPK3
	NOS3	PP	AKT1
	NPPA	PP	PRKCA
	NR1T2	PP	CYP3A4
	NRP1	PP	EGFR
	NTRK1	PP	NAPK3
	NTRK3	PP	NAPK3
	Nuclear factor NF	PP	CKCL1
	kappa B
	ODC1	PP	RHO4
	OSH	PP	NAPK3
	OXT	PP	PTES2
	P2Y receptor	PP	NAPK3
	PAK1	PP	TNF
	PAKR	PP	F2R
	PAKR	PP	TNF
	PC4	PP	PSNO9
	PCNA	PP	TP53
	PDGFB	PP	platelet-derived
			growth factor
	PDPK1	PP	RAS small monomeric
			GTPase
	PDPK1	PP	Rho small monomeric
			GTPase
	peptide receptor,	PP	RHOA
	G-protein coupled
	PGE1	PP	YAPK8
	PGE2	PP	CEBPB
	PGE2	PP	ILG
	Phosphatidylinositol	PP	EF4EBP1
	3-kinase
	Phosphatidylinositol	PP	PLA2G13
	3-kinase
	Phosphatidylinositol	PP	RAC1
	3-kinase

	TABLE 52
	Protein A		Protein B
	phospholipase	PP	TNF
	phospholipase C	PP	PLCG1
	PKA	PP	TGFB1
	PKC	PP	EGR1
	PKC	PP	ETS1
	PKC	PP	F2R
	PKC	PP	PRKCABP
	PKC	PP	RHOA
	PLA2G1B	PP	IL2
	PLA2G1B	PP	IL6
	PLA2G1B	PP	NAPK1
	PLA2G1B	PP	NAPK14
	PLA2G1B	PP	PTGS2
	platelet-derived	PP	AKT1
	growth factor
	platelet-derived	PP	EIF4E
	growth factor
	platelet-derived	PP	LPA
	growth factor
	platelet-derived	PP	SERPIKE1
	growth factor
	PLAUR	PP	integrin
	PLAUR	PP	PLAU
	PLAUR	PP	PLG
	PLAUR	PP	thronbin
	PLCG1	PP	choline phosphatase
	PLCG1	PP	fibroblast growth factor
	PLCG1	PP	growth factor receptor
	PLCG1	PP	HGF
	PLCG1	PP	inositol phosphate
	PLCG1	PP	inositol phosphates
	PLCG1	PP	INS
	PLCG1	PP	Phosphatidylinositol
			3-kinase
	PLCG1	PP	protein tyrosine kinase
	PLCG1	PP	src family
	PLCG1	PP	T-cell receptor
			T3 complex
	PLCG1	PP	TERF2TP
	PLG	PP	fibrin(ogen)
	PNA	PP	TGFB1
	POYC	PP	CXCL1
	POYC	PP	FN1
	POYC	PP	FOS
	POYC	PP	GH1
	POYC	PP	IL6
	PPARA	PP	CEBPG
	PRKCA	PP	INS
	PRKCA	PP	RAF1
	PRKCD	PP	FNA1
	PRKCD	PP	YAPK14
	PRKCD	PP	RAF1
	PRKCD	PP	TGF31
	PRKCE	PP	EGF
	PRKCE	PP	Nuclear factor NF
			kappa B
	PRKCE	PP	PKC
	PRKCE	PP	PRKCZ
	PRKCZ	PP	IL1
	PRKCZ	PP	map kinase
	PRKCZ	PP	Nuclear factor NF
			kappa B
	PRKCZ	PP	Phosphatidylinositol
			3-kinase
	PRKCZ	PP	RPS6K
	PRL	PP	IL18
	PRL	PP	INS
	PRL	PP	YAPK1
	PRL	PP	ODC1
	PRL	PP	STAT1
	PRL	PP	TAC1
	PROCR	PP	THBD
	progesterone	PP	NAPK1
	PROS1	PP	EL6R
	protein phosphatase	PP	YAPK8
	protein serine/	PP	NAPK1
	threonine kinase

	TABLE 53
	Protein A		Protein B
	protein tyrosine	PP	GAB1
	kinase
	protein tyrosine	PP	NAPK3
	kinase
	protein tyrosine	PP	RHOA
	kinase
	protein tyrosine	PP	TGFB1
	kinase
	PSYD9	PP	COKN1A
	PTEN	PP	CCND3
	PTGIS	PP	ADCY2
	PTGIS	PP	thromboxane A2
	PTGIS	PP	VEF
	PTGS2	PP	EGFR
	PTGS2	PP	HSPA4
	PTGS2	PP	YAP2K1
	PTGS2	PP	REN
	PTH	PP	voltage-gated calcium
			channel
	PTHLH	PP	IL6
	PTK2	PP	ARHGEF12
	PTK2	PP	GRB2
	PTK2B	PP	AGT
	PTK2B	PP	COKN1A
	PTK2B	PP	RPSGKB1
	PTK2B	PP	SYK
	PTPH11	PP	IL6
	RAC1	PP	ARF1
	RAC1	PP	ARF6
	RAC1	PP	CO44
	RAC1	PP	EGFR
	RAC1	PP	FGF2
	RAC1	PP	GDP
	RAC1	PP	IL1
	RAC1	PP	KITLG
	RAC1	PP	RASGRP1
	RAC1	PP	TNFSF6
	RAC1	PP	WASF2
	RAF1	PP	COKN1A
	RAF1	PP	EGFR
	RAF1	PP	ELK1
	RAF1	PP	HSPCA
	RAF1	PP	HAPK1
	RAF1	PP	SRC
	RAF1	PP	TGFB1
	RAPGEF1	PP	NAPK1
	RARA	PP	L3
	RARA	PP	TGFB1
	RAS small monomeric	PP	CDKN1A
	GTPase
	RAS small monomeric	PP	EGR1
	GTPase
	RAS small monomeric	PP	NAPK3
	GTPase
	RASGRP1	PP	NAPK1
	RB1	PP	HGF
	RB1	PP	NYC
	RBL1	PP	E2F4
	RELA	PP	TNFRSF6
	replication factor C	PP	NAPK1
	Rho kinase	PP	RHOA
	RHOA	PP	Glass A G-protein
			coupled receptor
	RHOA	PP	EGR1
	RHOA	PP	GNA12
	RHOA	PP	GNA13
	RHOA	PP	NCF2L
	RHOA	PP	PPPIR12A
	RHOC	PP	NAPK3
	RHOC	PP	RAC1
	ROCK1	PP	RHOA
	RPS6K	PP	COKN2A
	RPS6K	PP	ELK1
	RPS6K	PP	ERBB2
	RPS6K	PP	NAPK3
	RPS6K	PP	src family

	TABLE 54
	Protein A		Protein B
	RPS5KA2	PP	HAPK3
	RPS6KB1	PP	CSF2
	RPS6KB1	PP	GF1
	RPS6KB1	PP	AK
	RP56KB1	PP	SRC
	RRAS	PP	BCAR1
	RXRA	PP	TNF
	SAA2	PP	TNF
	SAP kinase	PP	N
	SAP kinase	PP	NAPK1
	SCYL1	PP	TNF
	SERPINE1	PP	F3
	SERPINE1	PP	IL6
	SFTPA1	PP	IL6
	SHC1	PP	IL6
	SHC1	PP	S
	SHC1	PP	NGFB
	SHC1	PP	PLDG1
	SIAH1	PP	CDKN1A
	signal peptide	PP	CRK
	peptidase
	small monomeric	PP	HAPK3
	GTPase
	SOSI	PP	HAPK8
	SPI	PP	SERPINE1
	SPB	PP	IFR6
	SRC	PP	CBL
	SRC	PP	CCND1
	SRC	PP	CTGF
	SRC	PP	ERBB2
	SRC	PP	HIF1A
	SRC	PP	ICAN1
	SRC	PP	NYG
	SRC	PP	NPPA
	SRC	PP	PTK2B
	SRC	PP	SHC1
	src family	PP	YAPK1
	src family	PP	YAPK3
	src family	PP	PTK2
	src family	PP	PTK2B
	SRF	PP	ELK1
	STAT1	PP	CSF1
	STAT1	PP	EGF
	STAT1	PP	IFNG
	STAT1	PP	IL2
	STAT1	PP	YAPK1
	STAT3	PP	HGF
	STAT3	PP	YAPK14
	STAT3	PP	STAT5A
	STAT5A	PP	BCL2L1
	STAT5A	PP	IL5
	STAT5A	PP	IL5
	STAT6	PP	IL4
	STAT6	PP	IL4R
	SYK	PP	FegammaRI
	SYK	PP	LYN
	T cell transition	PP	JUN
	factor NFATC
	TAC1	PP	FOS
	TAF1	PP	CCND1
	TAP1	PP	IFNG
	T-cell receptor	PP	IFNG
	T3 complex
	T-cell receptor	PP	HAPK1
	T3 complex
	TFIID	PP	TP53
	TGFA	PP	EGFR
	TGFA	PP	FNI
	TGFA	PP	HGF
	TGFA	PP	GF1
	TGFA	PP	IL1B
	TGFA	PP	IL6
	TGFA	PP	RAF1
	TGFA	PP	TP53

	TABLE 55
	Protein A		Protein B
	TGFB1	PP	ADP
	TGFB1	PP	alphaVbeta6
	TGFB1	PP	CRP
	TGFB1	PP	EDN1
	TGFB1	PP	HIF1A
	TGFB1	PP	IER2
	TGFB1	PP	ILIR1
	TGFB1	PP	IL8
	TGFB1	PP	ITGAE
	TGFB1	PP	LCP1
	TGFB1	PP	LTBP1
	TGFB1	PP	NF
	TGFB1	PP	NYB13
	TGFB1	PP	NYP14
	TGFB1	PP	HYB
	TGFB1	PP	HGFB
	TGFB1	PP	PDGFA
	TGFB1	PP	PDGFB
	TGFB1	PP	PTAS3
	TGFB1	PP	PKC
	TGFB1	PP	protein-glutamine gamma-
			glutanyltransferase
	TGFB1	PP	PTH
	TGFB1	PP	RHF7
	TGFB1	PP	SPARC
	TGFB1	PP	TFE3
	TGFB1	PP	TGFB3
	TGFB1	PP	TIEG
	TGFB1	PP	TIEG2
	TGFB1	PP	vitronectin receptor
			(integrin)
	TGFB1	PP	VTN
	TGFB2	PP	TGFB1
	TGFbetaR	PP	TGFB1
	THPO	PP	IL6
	thrombin	PP	PLCG1
	TLR2	PP	IL6
	TNF	PP	Achronobacter iophagus
			collagenase
	TNF	PP	AGTR1
	TNF	PP	ANGPT2
	TNF	PP	B2K
	TNF	PP	CADPS
	TNF	PP	calpain
	TNF	PP	CCLI1
	TNF	PP	CD14
	TNF	PP	CD69
	TNF	PP	CEACAV5
	TNF	PP	CRADD
	TNF	PP	CSF1
	TNF	PP	ECE1
	TNF	PP	EDN1
	TNF	PP	endothelin
	TNF	PP	EP300
	TNF	PP	FADD
	TNF	PP	FCER2
	TNF	PP	FN1
	TNF	PP	FS1
	TNF	PP	HTATIP
	TNF	PP	IL1
	TNF	PP	IL12B
	TNF	PP	IL15
	TNF	PP	IL18
	TNF	PP	IL1A
	TNF	PP	IL1B
	TNF	PP	IL1F8
	TNF	PP	IL2
	TNF	PP	IL2RB
	TNF	PP	IL7
	TNF	PP	IL8
	TNF	PP	integrin
	TNF	PP	interleukin-I receptor
			ligand
	TNF	PP	ITGB2

	TABLE 56
	Protein A		Protein B
	TNF	PP	ITIH4
	TNF	PP	JNK
	TNF	PP	JUND
	TNF	PP	LBP
	TNF	PP	LPS
	TNF	PP	NADCAK1
	TNF	PP	NAPK8
	TNF	PP	NAPKAPK2
	TNF	PP	matrix petalloproteinase
	TNF	PP	NDDC
	TNF	PP	NHP14
	TNF	PP	NYLK
	TNF	PP	nadph oxidase
	TNF	PP	NDUFA1
	TNF	PP	NFKB1
	TNF	PP	NGF8
	TNF	PP	NDS2A
	TNF	PP	PARP1
	TNF	PP	PGF2 alpha
	TNF	PP	PLA2G10
	TNF	PP	PLA2G1B
	TNF	PP	PLAU
	TNF	PP	PRKCE
	TNF	PP	PRKCH
	TNF	PP	PRKCZ
	TNF	PP	prostaglandin-
			endoperoxide synthase
	TNF	PP	protein serine/
			threonine kinase
	TNF	PP	protein lyrosine kinase
	TNF	PP	PTK28
	TNF	PP	RAF1
	TNF	PP	RAS small monomeric
			GTPase
	TNF	PP	replication factor C
	TNF	PP	RIPK1
	TNF	PP	RPSGK
	TNF	PP	T cell transcription
			factor NFATC
	TNF	PP	TACR1
	TNF	PP	TGFA
	TNF	PP	TNFRSF9
	TNF	PP	TNFSF5
	TNF	PP	TND1
	TNF	PP	TP53
	TNF	PP	VLDL
	TNF	PP	VTN
	TNFRSF1A	PP	VAPK3
	TNFRSF1A	PP	VAPK8
	TNFRSF5	PP	CCL5
	TNFRSF5	PP	IFNG
	TNFRSF5	PP	JUN
	TNFRSF6	PP	CASP3
	TNFRSF6	PP	CD4
	TNFRSF6	PP	CYCS
	TNFRSF6	PP	PARP1
	TNFSF10	PP	TP53
	TNFSF5	PP	CD40 receptor
	TNFSF5	PP	IFNG
	TNFSF6	PP	CD4
	TNFSF6	PP	CYCS
	TNFSF6	PP	JUN

	TABLE 57
	Protein A		Protein B
	TP53	PP	ABC81
	TP53	PP	AGT
	TP53	PP	AXTN1
	TP53	PP	CASP3
	TP53	PP	CAV1
	TP53	PP	CCNG1
	TP53	PP	CDKN1A
	TP53	PP	EGFR
	TP53	PP	FNL2
	TP53	PP	GADD45A
	TP53	PP	HES1
	TP53	PP	HGF
	TP53	PP	HRAS
	TP53	PP	NAPK8
	TP53	PP	NSH2
	TP53	PP	progesterone
	TP53	PP	PTEN
	TP53	PP	RACI
	TP53	PP	SLC12A9
	TP53	PP	SUH01
	TP53	PP	TNFSF6
	TP53	PP	TP53I3
	TP53	PP	NIG1
	TP73	PP	NYC
	TPA	PP	IL6
	TPSB1	PP	TGFB1
	TRAF2	PP	VAPK8
	TRAF5	PP	VAPK8
	tumor necrosis	PP	CDKN1A
	factor
	tumor necrosis	PP	NAPK3
	factor
	tumor necrosis	PP	NAPK8
	factor
	tumor necrosis	PP	RHOA
	factor
	TYK2	PP	IFNG
	Type I protein gerenyl-	PP	INS
	geranyltransferase
	USF1	PP	USF2
	VAV1	PP	NAOK8
	VCAN1	PP	ICAN1
	VCAN1	PP	NAPK14
	VEGF	PP	ANGPT2
	VEGF	PP	cANP-dependent protein
			kinase catalyst
	VEGF	PP	CSF1
	VEGF	PP	EGFR
	VEGF	PP	EGR1
	VEGF	PP	F3
	VEGF	PP	MAPK1
	VEGF	PP	PRKCA
	VEGF	PP	PTGS2
	VEGF	PP	RAF1
	VEGF	PP	RHOA
	VEGF	PP	RPSBKP1
	VEGF	PP	SERPINE1
	VEGF	PP	SHC1
	VEGF	PP	SRC
	VEGF	PP	STAT3
	VIP	PP	ADCY2
	VIP	PP	CREB1
	VIP	PP	LIF
	WARS	PP	IFNG

The protein information database 3 also stores information about how the intermolecular interaction between two molecules affects the cellular function.

How the intermolecular interaction between two molecules affects the cellular function is inferred in the following way.

For a molecule set of NN-type, the following steps are taken to infer how the intermolecular interaction between two molecules affects the cellular function. The first step is to select the cellular function to be affected simultaneously by two proteins of the molecule set of interest. It is assumed that when the cellular function X is promoted by protein A and suppressed by protein B, and protein A is on and protein B is off, the molecule set of protein A and protein B promotionally acts on the cellular function X. Conversely, it is assumed that when the cellular function X is suppressed by protein A and promoted by protein B, and protein A is off and protein B is on, the molecule set of protein A and protein B promotionally acts on the cellular function X.

The protein information database 3 stores information about how the intermolecular interaction (between two molecules) affects the cellular function with respect to each protein of the molecule set of NN-type. As its example, FIG. 3 shows the relation between the molecule set of NN-type relating to TP53 molecule and the cellular function that is promoted in response to on/off of the two proteins.

In the case of molecule set of NN-type involving TP53 and ABCC1 shown in FIG. 3A, it promotes no cellular function when TP53 is on and ABCC1 is off, and it promotes synthesis and motility as the cellular function when TP53 is off and ABCC1 is on.

In the case of molecule set of NN-type involving TP53 and telomerase shown in FIG. 3B, it promotes death and aging as the cellular function when TP53 is on and telomerase is off, and it promotes proliferation as the cellular function when TP53 is off and telomerase is on.

In the case of molecule set of NN-type involving TP53 and FGF2 shown in FIG. 3C, it promotes apoptosis, metabolic catabolism, aging, DNA fragmentation, death, and depolarization as the cellular function when TP53 is on and FGF2 is off, and it promotes mitosis, chromosome DNA replication, replication, amplification, synthesis, growth rate increase, advance of cell cycle to S phase, motility, angiogenesis, proliferation, and advance of cell state to G1 phase as the cellular function when P53 is off and FGF2 is on.

In the case of molecule set of NN-type involving TP53 and TERT shown in FIG. 3D, it promotes apoptosis, death, DNA damage recognition, and aging as the cellular function when TP53 is on and TERT is off, and it has no effect on the cellular function when P53 is off and TERT is on.

In the case of molecule set of NN-type involving TP53 and HSPA4 shown in FIG. 3E, it promotes apoptosis, DNA fragmentation, and death as the cellular function when TP53 is on and HSPA4 is off, and it has no effect on the cellular function when P53 is off and HSPA4 is on.

In the case of molecule set of NN-type involving TP53 and TXNRD1 shown in FIG. 3F, it has no effect on the cellular function when TP53 is on and TXNRD1 is off, and it promotes cell proliferation when TP53 is off and TXNRD1 is on.

Thus, the protein information database 3 stores any molecule set of NN-type involving other proteins than PT53 to show what cellular function is promoted when which protein is on.

For the relation between the cellular function and interaction between two molecules in the molecule set of PN-type, the molecule set of PN-type is assumed to positively act (POS) on the cellular function Y which is promoted by protein A and suppressed by protein B when promotive action is brought from protein A to protein B. Likewise, it is assumed to negatively act (NEG) on the cellular function Z which is suppressed by protein A and promoted by protein B.

The protein information database 3 stores information about the relation between the cellular function and the interaction between two molecules for proteins involved in the molecule set of PN-type. This is illustrated in FIGS. 4 to 9, which show the relation between the cellular function and the molecule set of PN-type involving TP53.

In the case of molecule set of PN-type involving ADP and TP53 as shown in FIG. 4A, ADP promotes the function of synthesis, motility, mitogenesis, and polymerization, and ADP suppresses the function of damage and DNA damage recognition. In the case of molecule set of PN-type involving AGTR2 and TP53 as shown in FIG. 4B, AGTR2 promotes the function of synthesis and motility, and AGTR2 suppresses the function of cell permeability.

In the case of molecule set of PN-type involving catenin and TP53 as shown in FIG. 4C, catenin promotes the function of motility and proliferation, and catenin does not suppress any specific function. In the case of molecule set of PN-type involving CCNE1 and TP53 as shown in FIG. 4D, CCNE1 promotes the function of chromosomal DNA replication, condensation, proteolysis, synthesis, G1-S transition, instability, advance of cell cycle to S phase, motility, mitogenesis, and advance of cell cycle to G1 phase, and CCNE1 does not suppress any specific function.

In the same way as mentioned above, proteins involved in the molecule sets of PN-type shown in FIGS. 4E to 4H and FIGS. 5 to 9 given later promote and suppress the cellular functions. This information is stored in the protein information database 3.

The relation between the cellular function and interaction between two molecules is inferred in the same way as mentioned above for the molecule set of PP-type, that is, two proteins are regarded as “POS” (for promotion) and “NEG” (for suppression), respectively, if they promote and suppress the specifically selected cellular function on which they act simultaneously.

The protein information database 3 stores information about relation between the interaction of two molecules and the cellular function for the molecule set of PP-type involving various proteins. FIGS. 10 to 14 show, as some of their examples, how the cellular function is affected by the molecule set of PN-type involving TP53 molecule.

The molecule set of PN-type involving TP53 and PTEN as shown in FIG. 10A promotes the cellular function of apoptosis, chemosensitivity, and death if both proteins act for promotion, and it promotes the function of cell proliferation, advance of cell cycle to G1 phase, G1-S transition, advance of cell cycle to S phase, angiogenesis, growth rate increase, G0-G1 transition, mitogensis, and RNA localization if both proteins act for suppression. The molecule set of PN-type involving TP53 and ABCB1 as shown in FIG. 10B promotes the cellular function of apoptosis and secretion (release from cells of molecules produced inside cells) if both proteins act for promotion, and it does not promote any specific cellular function if both proteins act for suppression.

The molecule set of PN-type involving TP53 and GADD45A as shown in FIG. 10C promotes the cellular function of DNA nucleotide-excision repair if both proteins act for promotion, and it promotes the function of mitogenesis, S phase, G2 phase, G1 phase, and proliferation if both proteins act for suppression. The molecule set of PN-type involving TP53 and MYC as shown in FIG. 10D promotes the cellular function of apoptosis, death, and secretion, if both proteins act for promotion, and it does not promote any specific cellular function if both proteins act for suppression.

In the same way as mentioned above, proteins involved in the molecule sets of PN-type shown in FIGS. 10E to 10G and FIGS. 11 to 14 given later promote and suppress the cellular functions. This information is stored in the protein information database 3.

Now, the description of FIG. 1 is revisited.

The protein information analyzing unit 4 includes the protein expression ratio arithmetic unit 21, the point accumulating unit 22, the factor setting unit 23, the operating input acquisition unit 24, the database building and processing unit 25, the network building unit 26, the target molecule inferring unit 27, and the result output unit 28.

The protein expression ratio arithmetic unit 21 receives from the mRNA expression analyzing unit 2 (or the protein kit 7) information about the amount of target protein expressed in normal cells and information about the amount of target protein expressed in sample cells. It compares the amount of target protein expressed in normal cells with the amount of target protein expressed in sample cells and calculates the increase or decrease of the amount of target protein expressed. It supplies the thus obtained value as the protein index to the point accumulating unit 22.

The point accumulating unit 22 receives the value of protein index from the protein expression ratio arithmetic unit 21 and calculates the accumulated value of scores for individual cellular functions by using the value of protein index of two proteins constituting the molecule set of NN-type, PN-type, and PP-type stored in the protein information database 3 and the value of the factor set up in the factor setting unit 23. If the point accumulating unit 22 gives a positive value of score for the cellular function, it means that the cell for detection promotes the cellular function; otherwise, it means that the cell for detection suppresses the cellular function.

The point accumulating unit 22 performs arithmetic process in the following manner for the molecule sets of NN-type, PN-type, and PP-type.

Association with cellular function and scoring are carried out as follows for the molecule set of NN-type involving INS and IFNG.

The point accumulating unit 22 receives from the protein expression ratio arithmetic unit 21 the values of protein index for the two proteins constituting the molecule set of NN-type and then calculates the absolute value of the difference between the two values. Subsequently, it assigns the absolute value to be positive or negative according to whether each cellular function is promoted or suppressed, and multiplies it by the factor set up by the factor setting unit 23, thereby giving the score of the cellular function associated with the molecule set.

The cellular function associated with INS and IFNG for the molecule set of NN-type is classified into two categories as shown in FIG. 15. The first category includes those cellular functions which are promoted by INS (denoted by--->) and suppressed by IFNG (denoted by---|). The second category includes those cellular functions which are suppressed by INS and promoted by IFNG. Those cellular functions which are promoted by INS and suppressed by IFNG include positive regulation of mitosis, mitogenesis, reorganization, G1 phase, transformation, assembling, proliferation, and morphogenesis. Those cellular functions which are suppressed by INS and promoted by IFNG include lypolysis, apoptosis, death, damage, rosette, permeation, and respiratory burst.

The point accumulating unit 22 receives the protein index of INS and the protein index of IFNG from the protein expression ratio arithmetic unit 21. If the difference between the two indexes for the cellular function promoted by INS is larger than 0, it adds a positive sign to the absolute value of the difference. If the difference between the two indexes is smaller than 0, then it adds a negative sign to the absolute value of the difference. It multiplies the signed value by the factor set up in the factor setting unit 23. The resulting value is the score of the cellular function controlled by the two proteins (shown in FIG. 15).

Association with cellular function and scoring are carried out as follows for the molecule set of PN-type involving INS and JUN.

The point accumulating unit 22 receives from the protein expression ratio arithmetic unit 21 the value of protein index for either of the two proteins constituting the molecule set of PN-type which is promoted. It makes the value positive or negative according to whether the cellular function is promoted or suppressed and then multiplies it by the factor set up by the factor setting unit 23, thereby giving the score of the cellular function associated with the molecule set.

The cellular function associated with INS and JUN for the molecule set of PN-type is classified into two categories as shown in FIG. 16. The first category includes those cellular functions which are promoted by INS and suppressed by JUN. The second category includes those cellular functions which are suppressed by INS and promoted by JUN. Those cellular functions which are promoted by INS and suppressed by JUN include steroid biosynthesis and mitogenesis. Those cellular functions which are suppressed by INS and promoted by JUN include DNA fragmentation and proteolysis. The point accumulating unit 22 makes positive the value of the protein index of INS for the cellular function promoted by the promoting protein (INS in the case in FIG. 3), and it makes negative the value of the protein index for the cellular function suppressed by INS. Then it multiplies the resulting value by the factor set up by the factor setting unit 23, thereby giving the score of the cellular function (shown in FIG. 16) controlled by the two proteins.

Association with cellular function and scoring are carried out as follows for the molecule set of PP-type involving TNF and TP53.

The point accumulating unit 22 receives from the protein expression ratio arithmetic unit 21 the values of protein index for the two proteins constituting the molecule set of PP-type and then calculates their product. Subsequently, it assigns the product to be positive or negative according to whether each cellular function is promoted or suppressed, and multiplies it by the factor set up by the factor setting unit 23, thereby giving the score of the cellular function associated with the molecule set.

The cellular function associated with INS and TP53 for the molecule set of PP-type is classified into two categories as shown in FIG. 17. The first category includes those cellular functions which are promoted by both proteins. The second category includes those cellular functions which are suppressed by both proteins. Those cellular functions which are promoted by both proteins include death, necrosis, damage, apoptosis, and secretion. Those cellular functions which are suppressed by both proteins include advance of cell cycle to G1 phase. The point accumulating unit 22 multiplies the product of indexes of both proteins by the factor set up by the factor setting unit 23 in the case of the cellular functions promoted by both proteins involved in the molecule set, thereby giving the score of the cellular function associated with the molecule set. The point accumulating unit 22 also multiplies the negative value of the product of indexes of both proteins by the factor set up by the factor setting unit 23 in the case of the cellular functions suppressed by both proteins involved in the molecule set, thereby giving the score of the cellular function associated with the molecule set.

The protein index is calculated in the following manner which is explained with reference to FIG. 18 for typical 19 kinds of proteins involving cell interactions on the basis of data showing the expression of mRNA of DAOY (cultured cell of human medulloblastoma).

In FIG. 18, “ori” (original) denotes the ratio of the occurrence of a specific protein (out of 19 proteins) in the control target to the occurrence of a specific protein (out of 19 proteins) in the sample target.

The combination of 19 proteins (shown in FIG. 18) gives the result of calculations for the molecule sets of NN-type. If the protein corresponding to the ordinate has a larger index than that corresponding to the abscissa, it means that the former is in the promotion (POS) side and hence the difference (in terms of absolute value) between the two indexes is obtained. If the protein corresponding to the ordinate has a smaller index than that corresponding to the abscissa, it means that the former is in the suppression (NEG) side and hence the difference (in terms of absolute value) between the two indexes is obtained. In other words, the difference between indexes of INS and IFNG is −0.40 for the corresponding cellular functions explained with reference to FIG. 15. This value is multiplied by the factor and the resulting product is assigned to be positive or negative according to whether the protein is in the promotion side or suppression side. The same calculations as above are performed on other molecule sets of NN-type.

The combination of 19 proteins (shown in FIG. 18) indicates how the protein index of the protein in the promotion side is associated with the cellular function for the molecule set of PN-type. In other words, it gives the score (calculated by multiplying the cellular function promoted by INS by the factor of 1.00) for the molecule set of INS and JUN (explained above with reference to FIG. 16). The same calculations as above are performed on other molecule sets of PN-type.

The combination of 19 proteins (shown in FIG. 18) indicates the product of the index of the protein corresponding to the ordinate and the index of the protein corresponding to the abscissa. The molecule set involving TNF and TP53 (which has been explained with reference to FIG. 17) gives the score obtained by multiplying −0.82 by the factor for the cellular function promoted by both proteins. The same calculations as above are performed on other molecule set of PP-type.

As mentioned above, the point accumulating unit 22 calculates the score of the cellular function (as explained with reference to FIGS. 15 to 18) for the molecule sets of NN-type, PN-type, and PP-type, and then accumulates the scores of individual cellular functions and supplies the results to the result output unit 28 and the target molecule inferring unit 27.

The factor setting unit 23 sets up the factor for score accumulation to be executed by the point accumulating unit 22. The factor should preferably be set up such that it takes the largest value for NN-type and the smallest value for PP-type. If there is a molecular bond between two molecules involved in the molecule set, the factor should be multiplied by a prescribed value larger than 1. These factors are previously obtained by experiment and experience; they may be set up in the factor setting unit 23 or may be changed by the user through processing in the operation input acquisition unit 24.

The operation input acquisition unit 24 is an input device such as keyboard, mouse, touch pad, and touch panel, which receives inputs in response to the user's operation. It permits the user to change the setting of the factor in the factor setting unit 23, to change the value of protein index in the simulation by the target molecule inferring unit 27 (mentioned later), and to update the database in the database building and processing unit 25. It supplies the entry to the factor setting unit 23, the target molecule inferring unit 27, and the database building and processing unit 25.

The database building and processing unit 25 updates and supplements various kinds of information stored in the protein information database 3 according to the user's input (which is supplied from the operating input acquisition unit 24) or database externally supplied through the network interface (not shown).

The target molecule inferring unit 27 performs simulation to infer the target molecule on the basis of score for each cellular function obtained from processing by the point accumulating unit 22.

The target molecule inferring unit 27 simulates the change of score for cellular function which occurs when the protein index of specific molecule changes in the expression of mRNA of DAOY (cultured cell of human medulloblastoma), which was explained above with reference to FIG. 18.

FIG. 19 shows the value (which is not yet multiplied by the factor) as the base of the score for the cellular function corresponding to individual molecule sets. The factor α for the protein index of AKT1 and IL6 is 0.1. Incidentally, AKT1 and IL6 are included in the 19 proteins (involving the expression of mRNA of DAOY) which were explained above with reference to FIG. 18.

The value in FIG. 19 differs from that in FIG. 18 in that the score for cellular function associated with FOS and AKT1 for the molecular set of NN-type is one which is obtained by multiplying −10.09 by a prescribed factor, because each protein index of AKT1 and IL6 is multiplied by 0.1. In addition, there is a difference between FIG. 19 and FIG. 18 in the value as the base for the score of cellular function associated with the molecule set of PP-type involving AKT1 and IL6.

FIG. 20 shows how the score for cellular function changes when the base value of score for cellular function is multiplied by the factor and the results are accumulated as shown in FIGS. 18 and 19. The cellular functions which change in accumulated values as shown in FIG. 20 are those which are seriously associated with cell proliferation and cell death. They include proliferation, apoptosis, cell survival, mitogenesis, angiogenesis, transformation, S phase, G2 phase, G2-M transition, G2 phase, G1-S transition, and G0-G1 transition.

As shown in FIG. 20, the score for cellular functions relating to proliferation, mitogenesis, angiogenesis, and transformation decreases and the score for cellular functions relating to apoptosis increases, with the factor α for AKT1 and IL6 set at 0.1.

The foregoing suggests that any treatment (with an anticancer agent, for example) to suppress the function of proteins (AKT1 and IL6) causes at least the cultured cell of human medulloblastoma (DAOY) to dye rather than proliferate. Finding a combination of proteins for the most remarkable effect will help search for the candidate of target molecule as an anticancer agent.

The target molecule inferring unit 27 may also be designed such that it performs simulation to infer the target molecule based on the protein network model built up by the network building unit 26.

The network building unit 26 builds up the molecule network based on the information stored in the protein information database 3. FIG. 21 shows the molecule network drawn from the molecule set of NN-type. The molecule network may also be drawn for the molecule sets of other types. The molecule network is drawn separately for individual categories, and it is also drawn three-dimensionally according to relations among individual proteins.

Any increase or decrease of the index of a certain protein in the protein network model built up by the network building unit 26 affects the index of other proteins connected with the network. The target molecule inferring unit 27 simulates the change of index of individual proteins in the network to infer how an increase or decrease of protein index at one node affects the protein index at other nodes (adjacent to the node in which the protein index has changed), on the assumption that the effect in the first adjacent node is 50%, the effect in the second adjacent node is 30%, the effect in the third adjacent node is 10%, and so on. The protein network model built up by the network building unit 26 consists of more than one molecule network (similar to that shown in FIG. 21) associated with one another, with their nodes connected with one another in a very complicated manner. It will permit more accurate inference of target molecules if it is modified such that consideration is given to the presence of the nodes which are affected through more than one route as the protein index increases or decreases.

The target molecule inferring unit 27 repeats the process of accumulating the score of cellular function by using the result of the simulation which has been carried out by means of the molecule network, thereby inferring the target molecule.

The result output unit 28 receives an accumulated score of cellular function from the point accumulating unit 22 or receives the result of inference of the target molecule from the target molecule inferring unit 27, and then delivers it to either or both of the result display unit 5 and the result analyzing unit 6.

The result display unit 5 consists of a display device such as CRT and LCD. It displays the result of accumulated score of cellular function or the result of inference of the target molecule which has been received from the result output unit 28. The user will be able to perform input operation to infer the target molecule by reference to the result of accumulated score for cellular function which is displayed on the result display unit 5.

The result analyzing unit 6 accumulates the result of accumulated score for cellular functions or the result of inference of the target molecule (which has been received from the result output unit 28) and then performs analysis according to need.

To be concrete, the result analyzing unit 6 accumulates chronologically the result of accumulated score for cellular functions of the same test subject and analyses the chronological change, so that it permits one to correctly judge whether or not the target protein has decreased as the result of medication to the test subject during the specific period. Moreover, it also permits one to confirm the effect (increase or decrease in expression) on other proteins or the effect on other cellular function by medication in that period.

This description is based on the assumption that the result analyzing unit 6 is independent of the protein information analyzing unit 4. However, the former may be included in the latter.

The protein analyzing system according to the present invention permits one to analyze in a simple manner any system anomaly of disease caused by anomalous molecule network in cells (such as cancer).

In other words, the protein analyzing system according to the present invention classifies interactions between two molecules into five categories which are NN-type for two proteins suppressing each other, PN-type for two proteins, with the first one promoting the second one and the second one suppressing the first one, PP-type for two proteins promoting each other, P-type for two proteins, with the first one only promoting the second one, and N-type for two proteins, with the first one only suppressing the second one, and calculates and accumulates the score for the cellular function associated with the pair of proteins falling under any of these categories, thereby digitizing the cellular function. Combining this result with the variation of cellular function makes it possible to infer the system structure of cells.

The present invention makes it possible to analyze the relation between the cellular function and the intermolecular action of proteins instead of merely paying attention to a single molecule. Therefore, it permits one to investigate the change in cellular function which occurs when the amount of specific proteins expressed fluctuates. This capability may be used to simulate a combination to restore the normal state by changing the anomalous cellular function (resulting from cancer, for example). In this way it is possible to infer the target molecule important for medical treatment.

The target molecule important for medical treatment will be inferred by means of the molecule network consisting of nodes representing proteins and links representing interactions classified into five categories mentioned above. In this way it is possible to infer the target molecule more accurately.

Once a correct target molecule is inferred, it would be very useful to establish an adequate way of medication to restore the anomalous system resulting from diseases.

In what follows, the process for analysis by means of the protein analyzing system will be described with reference to FIG. 22 (flow chart).

In Step S1, the chip forming unit 1 prepares a DNA chip to determine the amount of protein expressed (for analysis).

One DNA chip has more than one probe, so that it can determine the amount of more than one protein expressed.

In Step S2, the mRNA expression analyzing unit 2 carries out hybridization for the normal cell and the sample cell. To be concrete, this step is carried out as follows. The DNA chip, which has been prepared in Step S1, is given dropwise a target for control and a target for detection. The target for control is produced by using complementary DNA (cDNA) which has been replicated by reverse transcription from mRNA collected from normal cells. The target for detection is produced by reverse replication of complementary DNA (cDNA) from mRNA collected from sample cells. The probe and target are bound together (hybridized) through the reaction to form the complementary strands (double-strands) between the nucleic acids having the complementary base sequence.

In Step S3, the mRNA expression analyzing unit 2 calculates the amount of target protein expressed in normal cells and the amount of target protein expressed in sample cells, and then it sends the result to the protein expression ratio arithmetic unit 21 of the protein information analyzing unit 4.

The detailed procedure for Step S3 includes cleaning of the DNA chip, on which hybridization has occurred, and addition of an intercalator which emits fluorescence upon irradiation with exciting light, then the intercalator binds with the probe which has been hybridized. The intercalator binds with the probe in such a way that it does not enter between the probe and the target if they are not hybridized and it enters between the probe and the target only if they are hybridized. Upon irradiation with exiting light, the intercalator emits fluorescence, which is subsequently condensed by an object lens or the like and separated from exciting light by a prism. The condensed and separated fluorescence enters a photodiode for image analysis and calculation of the amount of target protein expressed.

In Step S4, the protein expression ratio arithmetic unit 21 of the protein information analyzing unit 4 calculates an increase or decrease in the amount of target protein expressed in the sample cells in comparison with the amount of target protein in the normal cells. Subsequently, it sends the result of calculations to the point accumulating unit 22. In other words, the protein expression ratio arithmetic unit 21 calculates the protein index on the basis of the amount of target protein (control) expressed in the normal cells and the amount of target protein expressed in the sample cells, both of which have been supplied from the mRNA expression analyzing unit 2. Then, it sends the result to the point accumulating unit 22.

In Step S5, the point accumulating unit 22 calculates the point accumulation (mentioned later) according to the flow sheet shown in FIG. 23. It obtains the accumulated value of the score times the factor for each cellular function, and it sends the result to the result output unit 28 and the target molecule inferring unit 27.

In Step S6, the result output unit 28 sends the result obtained in Step S5 to either or both of the result display unit 5 and the result analyzing unit 6.

In Step S7, the operating input acquisition unit 24 decides whether or not an instruction has been given to execute the target molecule inferring process.

In Step S8, the target molecule inferring unit 27 performs the process to infer the target molecule according to the flow sheets shown in FIG. 24 or 25 (mentioned later), if it is judged in Step S7 that an instruction has been issued to execute the process of inferring the target molecule.

In Step S9, the result analyzing unit 6 decides whether or not an instruction has been given to analyze the result of analysis of proteins which has been supplied from the result output unit 28 of the protein information analyzing unit 4, if it is decided in Step S7 that no instruction has been issued to execute the process of inferring the target molecule or after completion of the processing Step S8.

In Step S10, the result analyzing unit 6 chronologically analyzes the result of protein analysis if it is judged in Step S9 that an instruction has been issued to analyze the result of protein analysis. The procedure for analysis includes accumulating chronologically the result of accumulation of the score for cellular function of the same test subject, analyzing the chronological changes, confirming whether or not the target protein has decreased as the result of medication to the test subject during the prescribed period, and confirming the effect on other proteins due to medication in the prescribed period or the effect on other cellular functions.

Step S11 is to decide whether or not an instruction has been issued to terminate the processing if it is judged in Step S9 that an instruction has been issued to analyze the result of protein analysis or after completion of the processing in Step S10.

The process returns to Step S7 if it is decided in Step S11 that no instruction for processing has been received from the user, and the steps after S7 are repeated. The process ends if it is judged in Step S11 that an instruction for processing has been received from the user.

The foregoing processing gives the score of cellular function in response to the amount of expression for individual molecule sets classified according to interactions between two molecules. The score of cellular function permits one to infer the target molecule and to analyze chronologically the result of protein analysis.

In what follows, the process for point accumulation to be performed in Step S5 shown in FIG. 22 will be described with reference to the flow chart shown in FIG. 23.

In Step S41, the point accumulating unit 22 extracts one of the molecule sets of NN-type, PN-type, or PP-type, which involves the proteins whose expression has been detected.

In Step S42, the point accumulating unit 22 extracts the factor, which has been set up by the factor setting unit 23, according to the classification of the molecule sets (NN-type, PN-type, or PP-type) and the presence or absence of the molecular bond.

In Step S43, the point accumulating unit 22 detects whether each of cellular functions corresponding to the molecule sets is promoted or suppressed, by referencing the information about the relation between the molecule set and the cellular function shown in FIGS. 3 to 14 which is stored in the protein information database 3.

Each of the cellular functions is associated with the molecule set as explained with reference to FIGS. 15 to 17.

In Step S44, the point accumulating unit 22 multiplies by a factor the value as the base of the score (said value being obtained as explained with reference to FIG. 18) for the cellular function corresponding to the molecule set, thereby calculating the score for the cellular function.

In Step S45, the point accumulating unit 22 decides whether or not the score has been added to all the molecule sets. If it is judged in Step S45 that the score is not yet added to all the molecule sets, the step returns to Step S41 and subsequent steps are repeated.

If it is decided in Step S45 that the score has been added to all the molecule sets, the point accumulating unit 22 performs accumulation for each cellular function in Step S46, and the step returns to Step S5 and proceeds to Step S6 (shown in FIG. 22).

The above-mentioned process accumulates the score for each cellular function, thereby allowing one to know which cellular function is promoted or suppressed in the sample cells.

In what follows, the target molecule inferring process 1 to be performed in Step S8 shown in FIG. 22 will be described with reference to the flow chart shown in FIG. 24.

The target molecule inferring process 1 infers the target molecule based only on the changed value of the protein index, without using the molecule network.

In Step S71, the operating input acquisition unit 24 decides whether or not it has received an input for the changed value of the protein index. If the operating input acquisition unit 24 decides in Step S71 that it has not yet received an input for the changed value of the protein index, it repeats the process in Step S71 until it judges that it has received an input for the changed value of the protein index.

In Step S72, the operating input acquisition unit 24 sends the value of the protein index entered to the target molecule inferring unit 27 if it is judged in Step S71 that it has received an input for the changed value of the protein index. The target molecule inferring unit 27 sends the changed value of the protein index entered to the point accumulating unit 22, thereby causing the point accumulating unit 22 to accumulate the point by using the changed protein index as explained with reference to FIG. 19 in the same way as explained with reference to FIG. 23. The point accumulating unit 22 performs the process of accumulating the point by using the changed protein index and sends the result to the result output unit 28.

In Step S73, the result output unit 28 sends the result of calculation which supplied from the point accumulating unit 22 to the result output unit 28 and the target molecule inferring unit 27.

In Step S74, the operating input acquisition unit 24 decides whether or not it has received an input for the changed value of different protein index. If the operating input acquisition unit 24 decides in Step S74 that it has received an input for the changed value of different protein index, the process returns to Step S72 and the subsequent processes are repeated. If the operating input acquisition unit 24 judges in Step S74 that it has not yet received an input for the changed value of different protein index, the process returns to Step S8 shown in FIG. 22 and proceeds to Step S9.

The foregoing process performs point accumulation by using the changed protein index as explained with reference to FIG. 19, and permits one to infer what cellular function is promoted or suppressed when what protein decreases in amount of expression as explained with reference to FIG. 20. This makes it possible to infer the candidate of the target molecule for anticancer agents by seeking a protein or a combination of proteins which is most effective for the desired cellular function.

In what follows, the target molecule inferring process 2 to be performed in Step S8 shown in FIG. 22 will be described with reference to the flow chart shown in FIG. 25.

The target molecule inferring process 2 infers the target molecule by simulating the changed value of protein index for a plurality of molecules by using the molecule network.

In Step S101, the operating input acquisition unit 24 decides whether or not it has received an input for the changed value of the protein index. If the operating input acquisition unit 24 decides in Step S101 that it has not yet received an input for the changed value of the protein index, it repeats the process in Step S101 until it judges that it has received an input for the changed value of the protein index.

In Step S101, the operating input acquisition unit 24 sends the value of the protein index entered to the target molecule inferring unit 27 if it is decided in Step S101 that it has received an input for the changed value of the protein index. The target molecule inferring unit 27 sends the changed value of the protein index entered to the network building unit 26, thereby causing the network building unit 26 to calculate the variation of the protein index at individual nodes that occurs when the value of the prescribed protein index is changed in the molecule network built up by the network building unit 26. The network building unit 26 calculates the variation of the protein index at each node based on the changed value of the protein index supplied, and sends the result to the point accumulating unit 22.

It is desirable to have a means for considering the presence of nodes under influence of more than one route for the increase or decrease of the protein index at a certain node.

In Step S103, the point accumulating unit 22 accumulates the point by using the protein index after simulation in the same way as explained with reference to FIG. 23.

In Step S104, the result output unit 28 sends the result of calculation (which has been received from the point accumulating unit 22) to the result output unit 28 and the target molecule inferring unit 27.

In Step S105, the operating input acquisition unit 24 decides whether or not it has accepted the input of the changed value of the different protein index. If it is decided in Step S105 that the input of the changed value of the different protein index has been accepted, the process returns to Step S102 and the subsequent process is repeated. If it is decided in Step S105 that the input of the changed value of the different protein index has not been accepted, the process returns to Step S8 shown in FIG. 22 and then proceeds to Step S9.

The above-mentioned process accumulates the score for cellular function once again by using the result of simulation by means of the molecule network, thereby allowing one to infer the target molecule.

A series of processes mentioned above may be implemented by means of hardware or software. At least part of the above-mentioned process may be carried out by means of the personal computer 101 shown in FIG. 26.

In FIG. 26, the CPU (Central Processing Unit) 111 executes various processes according to the program stored in the ROM (Read Only Memory) 112 or the program loaded from the memory 118 to the RAM (Random Access Memory) 113. The RAM 113 also stores data necessary for the CPU 111 to perform various processes.

The CPU 111, the ROM 112, and the RAM 113 are connected to one another through the internal bus 114, which is connected to the input/output interface 115.

The input/output interface 115 is connected to the input device 116 such as keyboard and mouse, the output device 117 such as display and speaker, the memory unit 118 such as hard disk, and the communication unit 119 such as modem and terminal adaptor. The communication unit 119 performs communications through various networks including telephone circuit and CATV.

The input/output interface 115 is connected to the drive 120 according to need. The drive 120 may be equipped with the removable medium 121, such as magnetic disc, optical disc, magneto-optical disc, and semiconductor memory. The computer program is read out from the drive 120 and then installed in the memory 118 according to need.

In the case where software is used for processing, the program constituting the software is installed from the network or recording medium.

The recording medium may be the ROM 112 in which the program is recorded or the hard disc included in the memory device 118. In this case the ROM 112 and the hard disc are built into the personal computer delivered to the user. The program may also be recorded in the removal medium 121, which is distributed to the user separately from the computer proper.

In this specification, the steps for the program recorded in the recording medium may be carried out chronologically in the order listed; however, they may also be carried out in parallel or independently.

In this specification, the term “system” denotes an entire apparatus including a plurality of devices.

Incidentally, the embodiments of the present invention are not limited to those mentioned above; they may be modified variously without departing from the scope of the present invention.

Claims

1. An information processing apparatus which comprises: acquisition means that acquires the amount of the molecules for detection which have been produced by control cells and sample cells; arithmetic means that receives from said acquisition means the information about the amount of the molecules for detection which have been produced by said control cells and said sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection; and output control means that controls the output of the score which has been calculated by the arithmetic means for the cellular function.

2. The information processing apparatus as defined in claim 1, wherein the acquisition means acquires the amount of the molecules for detection which have been produced by the control cells and the sample cells, according to the amount of the nucleic acid which has been expressed in response to the molecules for detection which have been collected from the control cells and the sample cells.

3. The information processing apparatus as defined in claim 1, wherein the combination of the two molecules for detection is classified into the following five categories according to the interrelation between the two molecules; the first category applicable to two molecules which suppress each other, the second category applicable to two molecules the first one of which promotes the second one and the second one of which suppresses the first one, the third category applicable to two molecules which promote each other, the fourth category applicable to two molecules only one of which promotes the other, and the fifth category applicable to two molecules only one of which suppresses the other.

4. The information processing apparatus as defined in claim 1, wherein the arithmetic means calculates the score for the cellular functions by accumulating for each cellular function those values which are obtained by giving the score based on the amount of the molecules for detection which have been produced in the control cells and the sample cells to the cellular functions relating to the mutual promotion or suppression between the two molecules for detection which belong to the first to third categories out of said five categories and then multiplying a prescribed factor.

5. The information processing apparatus as defined in claim 4, wherein the prescribed factor is established such that it takes on the largest value for the cellular function relating to the first category of the first to third categories out of the five categories and it also takes on the smallest value for the cellular function relating to the third category of the first to third categories out of the five categories.

6. The information processing apparatus as defined in claim 4, wherein the prescribed factor is larger than 1 when the two molecules for detection have a molecular bond.

7. The information processing apparatus as defined in claim 1, further comprises storage means that stores in a table form the information about the combination of the two molecules for detection which are classified into any of the five categories and the cellular function relating to the mutual promotion or suppression of the two molecules for detection.

8. The information processing apparatus as defined in claim 1, further comprises estimating means that estimates the score for the cellular function when there is any change in the amount of the molecules for detection which have been produced in the control cells and the sample cells after it has been acquired by the acquisition means.

9. The information processing apparatus as defined in claim 8, further comprises network building means that builds a network for the information about the interrelation of the molecules for detection, wherein said estimating means calculates the effect of change in the amount of the molecules for detection which have been produced on other molecules based on the network which has been built by the network building means, thereby estimating the score for the cellular function.

10. The information processing apparatus as defined in claim 1, further comprises analyzing means that analyzes the change with time of the cellular function based on the score for the cellular function, with its output being controlled by the output control means.

11. An information processing method for an information processing apparatus that analyzes the cellular function relating to mutual promotion or suppression between two molecules to be detected, said method comprising the steps of: acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells; and receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.

12. A program to be executed by a computer to analyze the cellular function relating to mutual promotion or suppression between two molecules to be detected, said program comprising the steps of: acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells, and receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.

13. A recording medium which records the program as defined in claim 12.

14. An information processing system comprises: an analyzing unit that analyzes the amount of the molecules for detection which have been produced in the control cells and the sample cells; and an information processing apparatus that analyzes the information about the cellular function relating to the mutual promotion or suppression of the two molecules for detection, wherein said information processing apparatus includes: acquisition means that acquires the amount of the molecules for detection which have been produced by control cells and sample cells; arithmetic means that receives from said acquisition means the information about the amount of the molecules for detection which have been produced by said control cells and said sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection; and output control means that controls the output of the score which has been calculated by said arithmetic means for the cellular function.

15. An information processing apparatus comprises: an acquisition unit that acquires the amount of the molecules for detection which have been produced by control cells and sample cells; an arithmetic unit that receives from said acquisition unit the information about the amount of the molecules for detection which have been produced by said control cells and said sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection; and an output control unit that controls the output of the score which has been calculated by the arithmetic unit for the cellular function.