Claims
- 1. A method of inhibiting lipoxygenase in a patient having psoriasis, asthma, shock lung or oxygen intoxication, which comprises administering to such patient an effective amount of a compound of the formula ##STR48## wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SO.sub.n -alkyl (n=0 to 2) or SO.sub.n -trifluoromethyl (n=0 or 2), alkyl, alkenyl and alkoxy in each case being understood as meaning radicals with 1 to 4 C atoms,
- R.sup.1 represents hydrogen or a hydrocarbon radical which has 1 to 18 C atoms and optionally contains a hydroxyl, ether, ester or carbonyl group and optionally 1 to 3 halogen atoms,
- R.sup.2 has the meaning of R.sup.1 or represents a radical ##STR49## R.sup.3 represents hydrogen or an acyl or sulphonyl radical with in each case 1 to 5 C atoms and
- X represents one of the groups --O--CH.sub.2 --CH.sub.2 --, --S--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 -- or ##STR50## the oxygen or sulphur atom being bonded to the radical R, and with the proviso that X does not represent --O--CH.sub.2 --CH.sub.2 -- if R=.beta.-naphthyl, R.sup.1 =CH.sub.3 and R.sup.2 =R.sup.3 =H.
- 2. A method according to claim 1, in which R is naphthyl, diphenyl or phenyl radical which is optionally substituted once or twice by Cl or Br.
- 3. A method according to claim 1, in which R is an optionally substituted naphthyl radical.
- 4. A method according to claim 1, in which R.sup.1 and R.sup.2 each independently is hydrogen or a hydrocarbon radical which has 1 to 8 carbon atoms and optionally carries a hydroxyl, ether or ester group.
- 5. A method according to claim 1, in which each of R.sup.1 and R.sup.2 independently is an optionally branched C.sub.1 -C.sub.4 alkyl group or one of them is hydrogen, R.sup.1 and R.sup.2 together containing 2 to 7 carbon atoms.
- 6. A method according to claim 1, in which R.sup.3 is hydrogen or an aromatic acyl radical with 7 to 13 carbon atoms.
- 7. The method according to claim 1, in which the compound is ##STR51##
- 8. The method according to claim 1, where the patient has psoriasis and the compound is administered in an anti-psoriasis effective amount.
- 9. The method according to claim 1, wherein the patient has shock lung and the compound is administered in an anti-shock lung effective amount.
- 10. The method according to claim 1, where the patient has oxygen intoxication and the compound is administered in an anti-oxygen intoxication effective amount.
- 11. The method according to claim 1, where the patient has asthma and the compound is administered in an antiasthmatic effect amount.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3308881 |
Mar 1983 |
DEX |
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3342628 |
Nov 1983 |
DEX |
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Parent Case Info
This is a division of Application Ser. No. 609,933, filed May 14, 1984, now abandoned, which in turn is a continuation-in-part of Application Ser. No. 486,176, filed Apr. 18, 1983, now abandoned.
US Referenced Citations (8)
Divisions (1)
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Number |
Date |
Country |
Parent |
609933 |
May 1984 |
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Continuation in Parts (1)
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Number |
Date |
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486176 |
Apr 1983 |
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