INHIBITION OF HIV1 NEF-SH3 INTERACTIONS

Information

• Research Project
• 2421642

• ApplicationId

  2421642

• Core Project Number

  R43AI041807

• Full Project Number

  1R43AI041807-01

• Serial Number

  41807

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/1997 - 27 years ago

• Project End Date

  1/31/1998 - 26 years ago

• Program Officer Name

• Budget Start Date

  8/1/1997 - 27 years ago

• Budget End Date

  1/31/1998 - 26 years ago

• Fiscal Year

  1997

• Support Year

  1

• Suffix

• Award Notice Date

  7/25/1997 - 27 years ago

Organizations

• OSI Pharmaceuticals, Inc.

DESCRIPTION: (Adapted from Applicant's Abstract) Nef is a key protein involved in the pathway of HIV infectivity. Nef binds to the SH3 domain of the Src family of kinases, although its role in infectivity is still unclear. Using a newly developed assay for Nef-SH3 binding the investigators will use high-throughput screening of 40,000 fungal extracts for binding to the Nef-SH3 complex. After confirmation of activity, active extracts will be selected for initial purification and characterization of active principles.

IC Name

• Activity

  R43

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  856

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  ZRG5

• Study Section Name

• Organization Name

  OSI PHARMACEUTICALS, INC.

• Organization Department

• Organization DUNS

• Organization City

  UNIONDALE

• Organization State

  NY

• Organization Country

  UNITED STATES

• Organization Zip Code

  11553

• Organization District

  UNITED STATES