Claims
- 1. A method of treating hypertension in a patient, the method comprising administering to the patient a therapeutically effective amount of an inhibitor of epoxide hydrolase.
- 2. The method of claim 1, wherein the inhibitor is a compound having the structure
- 3. The method of claim 2, wherein W is carbon and Z is oxygen.
- 4. The method of claim 2, wherein X is nitrogen.
- 5. The method of claim 2, wherein Y is nitrogen.
- 6. The method of claim 2, wherein the inhibitor is dicylcohexylurea.
- 7. The method of claim 1, wherein the inhibitor is administered orally.
- 8. The method as in claim 1, wherein the inhibitor is administered in a total daily dose from about 0.001 μM/kg to about 100 mg/kg body weight of the patient.
- 9. The method of claim 1, wherein the patient is suffering from pregnancy-induced hypertension.
- 10. A method of identifying a patient at increased risk for hypertension, the method comprising assaying for epoxide hydrolase activity in a sample from the patient.
- 11. The method of claim 10, wherein the sample is a blood sample.
CROSS-REFERENCES TO RELATED APPLICATIONS
[0001] This application is a continuation in part of U.S. Ser. No. 09/252,148, filed Feb. 18, 1999, the entire disclosure of which is incorporated herein by reference.
Continuations (1)
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Number |
Date |
Country |
Parent |
09721261 |
Nov 2000 |
US |
Child |
10328495 |
Dec 2002 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09252148 |
Feb 1999 |
US |
Child |
09721261 |
Nov 2000 |
US |