Claims
- 1. A compound represented by formula (1):
- 2. A compound, pharmaceutically acceptable salt or active metabolite according to claim 1, wherein R2 is an unsubstituted cyclopentyl group.
- 3. A compound, pharmaceutically acceptable salt or active metabolite according to claim 2, wherein R3 is hydrogen.
- 4. A compound, pharmaceutically acceptable salt or active metabolite according to claim 3, wherein R1 is a heteroaryl group or a phenyl group, unsubstituted or substituted with one or more substituents selected from the group consisting of halogens; ═O; —OH; ═S; —SH; —N; alkyl; alkenyl; alkynyl; and —CH(CH3)2; or two or more substituents cyclize to form a fused or spiro polycyclic cycloalkyl; heterocycloalkyl; aryl; or heteroaryl group.
- 5. A compound according to claim 4, wherein R1 is a phenyl group or an unsubstituted heteroaryl group.
- 6. A compound according to claim 5, wherein R1 is a 5 membered heteroaryl ring including from 1 to 3 heteroatoms selected from N and S.
- 7. A compound selected from the group consisting of:
- 8. A compound represented by formula (1):
- 9. A pharmaceutical composition comprising: a therapeutically effective HCV-inhibiting amount of a compound, salt or active metabolite as defined in claim 1; and a pharmaceutically acceptable carrier therefore.
- 10. A method of inhibiting HCV polymerase activity comprising: contacting an HCV polymerase with an effective amount of a compound, salt or active metabolite as defined in claim 1.
- 11. A method of inhibiting HCV polymerase activity in mammalian tissue by administering an effective amount of a compound, salt or active metabolite as defined in claim 1 to said mammalian tissue.
- 12. A method according to claim 10, wherein said mammalian tissue is human tissue.
- 13. A method according to claim 10, wherein the compound, salt or active metabolite is administered orally or intravenously.
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application Ser. No. 60/369,381, filed Apr. 1, 2002.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60369381 |
Apr 2002 |
US |