Claims
- 1. A compound of Formula I or a pharmaceutically acceptable salt thereof, whereL1 is selected from (1) phenyl, (2) naphthyl, (3) dihydronaphthyl, and (4) tetrahydronaphthyl, where (1)-(4) can be optionally substituted with 1 or 2 substituents independently selected from (a) alkyl, (b) halogen, (c) perfluoroalkyl, and (d) —OR3 where R3 is selected from (a) hydrogen and (b) alkyl; R1 is hydrogen; R2 is selected from (1) alkyl where the alkyl can be optionally substituted with 1, 2, or 3 substituents independently selected from (a) —CO2R4 where R4 is selected from (i) hydrogen, (ii) alkyl, and (iii) a carboxy-protecting group and (b) —S(O)tR7, where R7 is selected from (i) hydrogen, (ii) alkyl, and (iii) aryl, andZ is —C(O)R12 where R12 is where R16 is alkyl, where the alkyl is substituted with 1, 2, or 3 cycloalkyl substituents.
- 2. A compound according to claim 1 where L1 is phenyl and R2 is alkyl substituted with one —CO2R4 and one —S(O)tR7 substituent.
- 3. A compound according to claim 2 where R4 is hydrogen.
- 4. A compound according to claim 3 where R7 is methyl.
- 5. A compound according to claim 4 which isN-4-[1-(3-Cyclohexylpropyloxycarbonyl)-3-(2-methylphenyl)-1,2,5,6-tetrahydroisonicotinyl]methionine.
- 6. A method of inhibiting protein isoprenyl transferases in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of claim 1.
- 7. A composition for inhibiting protein isoprenyl transferases comprising a pharmaceutical carrier and a therapeutically effective amount of a compound of claim 1.
Parent Case Info
This application claims the benefit of U.S. Provisional Application for Patent No. 60/109,347, filed Nov. 20, 1998.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5965539 |
Sebti et al. |
Oct 1999 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
9500497 |
Jan 1995 |
WO |
9717070 |
May 1997 |
WO |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/109347 |
Nov 1998 |
US |