Claims
- 1. A method for augmenting tissue in a living mammal, said method comprising subcutaneously injecting a composition including a ceramic matrix present in a pharmaceutically acceptable fluid carrier to a tissue site, wherein the ceramic matrix comprises particles having a size distribution in the range from 50 .mu.m to 250 .mu.m.
- 2. A method as in claim 1, wherein the tissue is soft tissue.
- 3. A method as in claim 1, wherein the tissue is hard tissue.
- 4. A method as in claim 1, wherein the composition is injected using a 20 gauge or finer needle.
- 5. A method as in claim 1, wherein the ceramic matrix is composed of calcium phosphate mineral particles.
- 6. A method as in claim 3, wherein the calcium phosphate mineral particles are composed of a material selected from the group consisting of sintered hydroxyapatite and tricalcium phosphate.
- 7. A method as in claim 1, wherein the ceramic matrix is present in the fluid carrier at a concentration from 0.75 gm/ml to 0.05 gm/ml.
- 8. A method as in claim 1, wherein the fluid carrier comprises a biocompatible organic polymer which will dissipate from a tissue injection site, leaving the mineral particles.
- 9. A method as in claim 8, wherein the organic polymer is a polyethylene glycol.
- 10. A method as in claim 1, further comprising collagen, wherein the ceramic matrix and collagen are suspended in an aqueous fluid carrier.
- 11. A method as in claim 10, wherein the ceramic matrix and the collagen are present at a weight ratio in the range from 1:19 to 1:1 ceramic matrix:collagen.
- 12. A method as in claim 1, wherein the composition further comprises a biocompatible fluid lubricant.
- 13. A method as in claim 12, wherein the biocompatible fluid lubricant is glycerol or succinylated collagen.
- 14. A method as in claim 1, wherein the composition further comprises at least one positively charged biologically active substance.
- 15. A method as in claim 12, wherein the substance is a tissue growth factor.
- 16. A method as in claim 1, wherein the tissue is bone and the composition further comprises a substance selected from the group consisting of osteogenic factor and bone marrow.
Parent Case Info
This is a division of application Ser. No. 07/843,646, filed Feb. 28, 1992.
US Referenced Citations (8)
Non-Patent Literature Citations (3)
Entry |
Lemons et al. Second World Congress of Biomaterials, Apr. 27-May 1, 1984. |
Polytef.RTM. Paste (Mentor Corporation, Santa Barbara, Calif.) 2 page description. |
Hench, "Bioglass Implants for Otology," in: Biomaterials in Otology, Grote, ed., pp. 62-69, Martinus Nijhoff Publ. (1983). |
Divisions (1)
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Number |
Date |
Country |
Parent |
843646 |
Feb 1992 |
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