Claims
- 1. A method of in situ formation of a solid polymer in a mammal, said method comprising:
- injecting into said mammal a physiologically-acceptable polymeric composition comprised of a polymeric compound dissolved in a water soluble, non-toxic polar solvent, said polymeric compound comprising a water insoluble, non-toxic non-crosslinked polymer or copolymer selected from the group consisting of polymers and copolymers of acrylonitrile, polyvinylacetate, copolymers of polyvinylacetate, linear or slightly branched polymers and copolymers of 2-hydroxyethylacrylate and methylacrylate, poly (n-vinyliminocarbonyl), polycondensates and polyadducts and having a solubility parameter of from about 9.2 to about 15.5 (cal/cc).sup.1/2.
- 2. The method of claim 1 wherein said polymeric compound is insoluble in blood serum below about 50.degree. C.
- 3. The method of claim 2 wherein said polymeric compound is soluble in said solvent at temperatures below 40.degree. C.
- 4. The method of claim 1 wherein said polymeric compound is a copolymer of acrylonitrile with a derivative of acrylic acid and selected from the group consisting of acrylamide, N-substituted acrylamide, acrylhydrazide, N-substituted acrylhydrazide, acrylic acid, acrylic acid salts, glutarimide and vinylsulfonate.
- 5. The method of claim 1 wherein said copolymer of polyvinylacetate is poly(vinylacetate-co-venylalcohol).
- 6. The method of claim 1 wherein said solvent has a molecular weight below about 200 and exhibits at least a moderate hydrogen bonding ability.
- 7. The method of claim 6 wherein said solvent is selected from the group consisting of dimethyl sulfoxide (DMSO), glycerol, glycerol monoacetate, glycerol diacetate (diacetin), methanol, ethanol, propanol, iso-propanol, cyclic ethylene carbonate, cyclic propylene carbonate, dimethyl formamide, tetramethylene sulfoxide, N--N-diethylacetamide, N,N,-dimethylacetamide, ethylene glycol, propylene glycol, triethylene glycol and diethylene glycol and mixtures thereof.
- 8. The method of claim 6 wherein said solvent is dimethylsulfoxide.
- 9. The method of claim 8 wherein said polymeric compound is in a concentration of from 0.1 to 50 percent by weight.
- 10. The method of claim 1 wherein said water insoluble non-cross linked polymer contains at least 2 weight percent nitrile groups.
- 11. The method as defined in claim 1 wherein said acrylonitrile-containing copolymer is produced by the partial acid-catalyzed hydrolysis of a polymer containing at least 85 molar percent of acrylonitrile units.
- 12. The method as defined in claim 1 wherein said polymeric composition after injection results in a polymeric form containing from 25 to 99 percent by weight water.
- 13. The method as defined in claim 12 wherein said polymeric form contains from 45 to 95 percent by weight water.
- 14. The method as defined in claim 13 wherein said polymeric composition, after injection, results in a polymeric form containing from 50 to 99 percent by weight water.
- 15. The method as defined in claim 14 wherein said polymeric form contains 70 to 95 percent by weight water.
Parent Case Info
This is a continuation-in-part of application Ser. No. 528,058 filed Aug. 31, 1983, abandoned.
US Referenced Citations (7)
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
528058 |
Aug 1983 |
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