Claims
- 1. An injectable solution made by the process comprising the steps of:
- (a) freeze drying an aqueous solution having a pH not less than 11 and comprising a compound represented by the formula: ##STR4## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group, R.sup.2 and R.sup.3, being the same or different from each other, represent hydrogen or methyl group, and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, and N-methylglucamine; and
- (b) mixing the freeze-dried material with polyethylene glycol 400 and an acidic substance in water to obtain and injectable solution having a pH of 7 to 11.
- 2. An injectable solution according to claim 1, of pH 7 to 11 which comprises a solution wherein a freeze-dried material of an alkaline aqueous solution containing N-methylglucamine and a compound represented by formula; ##STR5## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group, R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, said alkaline aqueous solution being not less than pH 11, has been dissolved with a mixed solution of (a) an acidic substance and (b) polyethylene glycol 400.
- 3. An injectable solution according to claim 1, wherein said freeze-dried material is a freeze-dried material of said alkaline aqueous solution containing a saccharide besides said compound.
- 4. An injectable solution according to claim 1, wherein said saccharide is mannitol.
- 5. An injectable solution according to claim 1, wherein said acidic substance is hydrochloric acid or sodium dihydrogenphosphate.
- 6. An injectable solution according to claim 1, wherein said mixed solution additionally contains sodium chloride.
- 7. An injectable solution according to claim 1, wherein said mixed solution contains N-methylglucamine and sodium chloride.
- 8. An injectable solution according to claim 1, wherein said acidic substance is hydrochloric acid or sodium dihydrogenphosphate.
- 9. An injectable solution made by the process comprising the steps of:
- (a) freeze drying an aqueous solution having a pH not less than 11 and comprising a compound represented by the formula: ##STR6## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group, R.sup.2 and R.sup.3, being the same or different from each other, represent hydrogen or methyl group, and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group; and
- (b) mixing the freeze-dried material with polyethylene glycol 400, an acidic substance and N-methylglucamine in water to obtain an injectable solution having a pH of 7 to 11.
- 10. An injectable solution according to claim 9, of pH 7 to 11 which comprises a solution wherein a freeze-dried material of an alkaline aqueous solution containing N-methylglucamine and a compound represented by formula; ##STR7## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group, R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, said alkaline aqueous solution being not less than pH 11, has been dissolved with a mixed solution of (a) an acidic substance and (b) polyethylene glycol 400.
- 11. An injectable solution according to claim 9, wherein said freeze-dried material is a freeze-dried material of said alkaline aqueous solution containing a saccharide besides said compound.
- 12. An injectable solution according to claim 9, wherein said saccharide is mannitol.
- 13. An injectable solution according to claim 9, wherein said acidic substance is hydrochloric acid or sodium dihydrogenphosphate.
- 14. An injectable solution according to claim 9, wherein said mixed solution additionally contains sodium chloride.
- 15. An injectable solution according to claim 9, wherein said mixed solution contains N-methylglucamine and sodium chloride.
- 16. An injectable solution according to claim 9, wherein said acidic substance is hydrochloric acid or sodium dihydrogenphosphate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
63-205100 |
Aug 1988 |
JPX |
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Parent Case Info
This application is a continuation of U.S. application Ser. No. 07/734,129 filed Jul. 25, 1991, now abandoned, which is a continuation of Ser. No. 07/480,907 filed Feb. 16, 1990, abandoned, which is a continuation-in-part of Ser. No. 07/395,357 filed Aug. 17, 1989, abandoned.
US Referenced Citations (7)
Non-Patent Literature Citations (3)
Entry |
CA105:133883y Nohara et al. Pyridylmethylthio benzimidazdes and their Sulfoxides 1986. |
U.S. Merck Index (#5945 & 7644) 9th Edition (1976). |
U.S. Pharmacopeiz (1980) pp. 464-465. |
Continuations (2)
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Number |
Date |
Country |
Parent |
734129 |
Jul 1991 |
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Parent |
480907 |
Feb 1990 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
395357 |
Aug 1989 |
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