Rhinitis is a medical condition that presents as irritation and inflammation of the mucous membrane within the nasal cavity. The inflammation results in the generation of excessive amounts of mucus, which can cause runny nose, nasal congestion, sneezing, and/or post-nasal drip. Allergenic rhinitis is an allergic reaction to environmental factors such as airborne allergens, while non-allergenic (or “vasomotor”) rhinitis is a chronic condition that presents independently of environmental factors. Conventional treatments for rhinitis include antihistamines, topical or systemic corticosteroids, and topical anticholinergics, for example.
For cases of intractable rhinitis in which the symptoms are severe and persistent, an additional treatment option is the surgical removal of a portion of the vidian (or “pterygoid”) nerve—a procedure known as vidian neurectomy. The theoretical basis for vidian neurectomy is that rhinitis is caused by an imbalance between parasympathetic and sympathetic innervation of the nasal cavity, and the resultant over stimulation of mucous glands of the mucous membrane. Vidian neurectomy aims to disrupt this imbalance and reduce nasal mucus secretions via surgical treatment of the vidian nerve. However, in some instances, vidian neurectomy can cause collateral damage to the lacrimal gland, which is innervated by the vidian nerve. Such damage to the lacrimal gland may result in long-term health complications for the patient, such as chronic dry eye. Posterior nasal neurectomy, or surgical removal of a portion of the posterior nasal nerves, may be an effective alternative to vidian neurectomy for treating intractable rhinitis.
While instruments and methods for performing vidian neurectomies and posterior nasal neurectomies are known, it is believed that no one prior to the inventors has made or used the invention described in the appended claims.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and, together with the general description of the invention given above, and the detailed description of the embodiments given below, serve to explain the principles of the present invention.
The drawings are not intended to be limiting in any way, and it is contemplated that various embodiments of the invention may be carried out in a variety of other ways, including those not necessarily depicted in the drawings. The accompanying drawings incorporated in and forming a part of the specification illustrate several aspects of the present invention, and together with the description serve to explain the principles of the invention; it being understood, however, that this invention is not limited to the precise arrangements shown.
The following description of certain examples of the invention should not be used to limit the scope of the present invention. Other examples, features, aspects, embodiments, and advantages of the invention will become apparent to those skilled in the art from the following description, which is by way of illustration, one of the best modes contemplated for carrying out the invention. As will be realized, the invention is capable of other different and obvious aspects, all without departing from the invention. Accordingly, the drawings and descriptions should be regarded as illustrative in nature and not restrictive.
For clarity of disclosure, the terms “proximal” and “distal” are defined herein relative to a surgeon, or other operator, grasping a surgical instrument having a distal surgical end effector. The term “proximal” refers to the position of an element arranged closer to the surgeon, and the term “distal” refers to the position of an element arranged closer to the surgical end effector of the surgical instrument and further away from the surgeon. Moreover, to the extent that spatial terms such as “top,” “bottom,” “upper,” “lower,” “vertical,” “horizontal,” or the like are used herein with reference to the drawings, it will be appreciated that such terms are used for exemplary description purposes only and are not intended to be limiting or absolute. In that regard, it will be understood that surgical instruments such as those disclosed herein may be used in a variety of orientations and positions not limited to those shown and described herein.
As used herein, the terms “about,” “approximately,” and the like in connection with any numerical values or ranges of values are intended to encompass the exact value(s) referenced, as well as a suitable dimensional tolerance that enables the referenced feature or combination of features to function for the intended purpose described herein.
I. Overview of Exemplary RF Ablation Surgical System
Endoscope (120) of the present example includes a body (122) that may function as a handle, and an elongate rigid shaft (124) extending distally from body (122) along a central longitudinal axis (A1) (see
To adjust the field of view (FOV) of endoscope (120), endoscope shaft (124) is selectively rotatable relative to body (122) about the central longitudinal axis (A1), and the swing prism (not shown) housed within the distal end of endoscope shaft (124) is selectively movable relative to endoscope shaft (124). To provide such adjustment, endoscope body (122) includes a distal dial (128) that is selectively rotatable about the central longitudinal axis (A1) of endoscope (120) to rotate endoscope shaft (124) relative to body (122) about the central longitudinal axis (A1). Body (122) further includes a proximal dial (130) that is selectively rotatable about the central longitudinal axis (A1) to pivot the swing prism (not shown) within and relative to endoscope shaft (124). Accordingly, selective actuation of dials (128, 130) enables an operator to move the field of view (FOV) of endoscope (120) to thereby visualize a particular anatomical region of interest within a patient during a procedure without having to flex endoscope shaft (124).
RF ablation instrument (140) is configured to be fixedly secured to and supported by rigid shaft (124) of endoscope (120) such that ablation head (150) is positioned with the field of view (FOV) of endoscope (120). Accordingly, an operator may visualize via endoscope (120) an ablation procedure being performed with RF ablation instrument (140), as described in greater detail below. As shown best in
As shown in
In some versions, ablation head (150) may include a single electrode configured to deliver monopolar RF energy to tissue positioned in contact with the electrode, in combination with a ground pad (not shown) positioned in contact with the patient's skin. Accordingly, it will be appreciated that ablation head (150) may be suitably configured to deliver bipolar or monopolar RF energy to tissue based on the selected surgical application. For instance, in surgical applications in which more localized treatment of tissue is desired, ablation head (150) may be configured with two or more electrodes (154, 156) operable to treat tissue with bipolar RF energy. For other surgical applications warranting a deeper treatment of the targeted tissue, ablation head (150) may be configured with a single RF electrode operable to treat tissue with monopolar RF energy. Furthermore, in addition to or in lieu of one or more RF ablation electrodes, ablation head (150) may include a resistance heating device, a cryoablation applicator, a chemical applicator, and/or an optical energy transmission device operable to ablate tissue.
In other examples, ablation head (150) may further comprise one or more tissue sensors operable to sense a condition of the tissue (e.g., a nerve) being ablated by electrodes (154, 156). Each such sensor may communicate a signal to a processor (not shown) of surgical system (100) indicating the sensed condition. In response to receiving the signal, the system processor may then regulate (e.g., deactivate) the RF ablation energy being delivered to electrodes (154, 156) from RF generator (170), and/or provide an indication to the operator informing of the sensed tissue condition. In some versions, ablation head (150) may include a tissue sensor in the form of a thermocouple (not shown) operable to measure a temperature of the tissue during ablation. In such versions, the system processor may deactivate delivery of RF ablation energy to electrodes upon determining that the sensed tissue temperature has reached a threshold temperature.
In other versions, ablation head (150) may include a tissue sensor in the form of a pair of detection electrodes operable to deliver a low power RF signal to the target tissue to measure an electrical impedance of the tissue during ablation. In some such versions, such detection electrodes may be provided separately from electrodes (154, 156) of ablatio head (150). In other such versions, electrodes (154, 156) may be operable as both ablation electrodes and as detection electrodes. In either configuration, the low power RF signal may be delivered to the target tissue simultaneously or in rapidly alternating fashion with the high-power RF ablation energy delivered by electrodes (154, 156). While the target tissue remains substantially intact and unablated, the low power RF signal will pass freely through the tissue with a relatively low impedance. As ablation of the tissue progresses, the detection electrodes will detect an increase in impedance of the tissue, which is communicated to the system processor.
As shown in
As shown in
As shown in
As shown in
Though not shown herein, RF ablation instrument (140) may be combined with features of an image-guided surgery (IGS) navigation system to further facilitate positioning of ablation head (150) within a patient. By way of example, such an IGS navigation system may be constructed and operable in accordance with at least some of the teachings of U.S. Pat. No. 7,720,521, entitled “Methods and Devices for Performing Procedures within the Ear, Nose, Throat and Paranasal Sinuses,” issued May 18, 2010, the disclosure of which is incorporated by reference herein; and/or U.S. Pat. Pub. No. 2014/0364725, entitled “Systems and Methods for Performing Image Guided Procedures within the Ear, Nose, Throat and Paranasal Sinuses,” published Dec. 11, 2014, now abandoned, the disclosure of which is incorporated by reference herein.
II. Exemplary Method of Ablating Posterior Nasal Nerve
Having described exemplary features of RF ablation surgical system (100) above, an exemplary method of performing a neurectomy on a posterior nasal nerve (40) of a patient with system (100) will now be described in connection with
Before insertion of the distal end of instrument assembly (110) into the patient, distal shaft portion (146) of RF ablation instrument (140) is manually bent by the operator as needed to position ablation head (150) within the field of view (FOV) of endoscope (120). In the present example, distal shaft portion (146) (and optionally also a portion of proximal shaft portion (144)) is suitably bent such that ablation head (150) is offset from proximal shaft portion (144) and endoscope shaft (124), and such that electrodes (154, 156) face away from endoscope window (126), as described above in connection with
The distal end of instrument assembly (110) is then inserted into the nasal cavity (10) of the patient and advanced toward a treatment site (TS) at the posterior ends of the inferior and middle turbinates (20, 22), under visualization provided by endoscope (120). While advancing toward the treatment site (TS), the operator manipulates endoscope (120) as needed to position electrodes (154, 156) of ablation head (150) in contact with the portion of nasal wall (18) in which the target posterior nasal nerve (40) resides. For instance, the operator may selectively rotate distal dial (128) of endoscope (120) to thereby rotate endoscope shaft (124) and thus RF ablation instrument (140) about the central endoscope axis (A1) to better position ablation head (150) relative to the posterior nasal nerve (40) at the treatment site (TS). Because ablation head (150) remains within the endoscope field of view (FOV) throughout this process, the operator is able to maintain visualization of ablation head (150) and thereby ensure accurate placement of ablation head (150) relative to the treatment site (TS). It will be appreciated that malleable distal shaft portion (146) of RF ablation instrument (140) may be provided with sufficient rigidity to resist unintended bending when ablation head (150) is pressed against nasal wall (18) with the minimum force necessary to maintain direct contact of electrodes (154, 156) with the nasal wall tissue to enable delivery of RF ablation energy.
As shown in
Following the surgical procedure, RF ablation instrument (140) may be separated from endoscope shaft (124) and disposed of; and replaced with a fresh RF ablation instrument (140) for a subsequent surgical procedure. In other examples, RF ablation instrument (140) may be configured to undergo sterilization along with endoscope (120), such that RF ablation instrument (140) may be reused multiple times.
III. Exemplary Combinations
The following examples relate to various non-exhaustive ways in which the teachings herein may be combined or applied. It should be understood that the following examples are not intended to restrict the coverage of any claims that may be presented at any time in this application or in subsequent filings of this application. No disclaimer is intended. The following examples are being provided for nothing more than merely illustrative purposes. It is contemplated that the various teachings herein may be arranged and applied in numerous other ways. It is also contemplated that some variations may omit certain features referred to in the below examples. Therefore, none of the aspects or features referred to below should be deemed critical unless otherwise explicitly indicated as such at a later date by the inventors or by a successor in interest to the inventors. If any claims are presented in this application or in subsequent filings related to this application that include additional features beyond those referred to below, those additional features shall not be presumed to have been added for any reason relating to patentability.
A surgical instrument comprising: (a) an elongate shaft having a proximal shaft portion and a malleable distal shaft portion, wherein the elongate shaft is configured to be secured to a supporting surgical instrument; and (b) an ablation head coupled to the malleable distal shaft portion, wherein the ablation head includes at least one electrode operable to deliver RF energy to tissue for ablating the tissue, wherein the ablation head is sized to fit within the nasal cavity of a patient with a distal end of the supporting surgical instrument, wherein the proximal shaft portion is configured to operatively couple with an RF energy source operable to energize the at least one electrode with RF energy, wherein the malleable distal shaft portion is configured to bend relative to a longitudinal shaft axis defined by the proximal shaft portion for selectively orienting the ablation head relative to the longitudinal shaft axis.
The surgical instrument of Example 1, wherein the at least one electrode comprises first and second electrodes operable to deliver bipolar RF energy to tissue.
The surgical instrument of any of the preceding Examples, wherein the ablation head defines a distal end of the RF ablation instrument.
The surgical instrument of any of the preceding Examples, wherein the ablation head extends distally from the malleable distal shaft portion along a head axis, wherein the malleable distal shaft portion is configured to bend relative to the longitudinal shaft axis to orient the ablation head in a position in which the head axis is offset from and parallel to the longitudinal shaft axis.
The surgical instrument of any of the preceding Examples, wherein the ablation head comprises a planar surface, wherein the at least one electrode is disposed on the planar surface.
The surgical instrument of any of the preceding Examples, wherein the ablation head is rectangular.
The surgical instrument of any of the preceding Examples, further comprising an electrical conductor housed within the elongate shaft, wherein the electrical conductor is configured to electrically couple the at least one electrode of the ablation head with the RF energy source.
The surgical instrument of any of the preceding Examples, wherein the elongate shaft comprises an electrically conductive material configured to electrically couple the at least one electrode of the ablation head with the RF energy source.
The surgical instrument of any of the preceding Examples, further comprising an electrical connector coupled with the proximal shaft portion, wherein the electrical connector is configured to releasably couple with the RF energy source to place the at least one electrode in electric communication with the RF energy source.
A surgical instrument assembly comprising: (a) an endoscope, wherein the endoscope comprises: (i) an endoscope shaft, and (ii) a distal end through which the endoscope is configured to capture an image of patient anatomy; and (b) the surgical instrument of any of the preceding Examples, wherein the proximal shaft portion of the surgical instrument is secured relative to the endoscope shaft.
The surgical instrument assembly of Example 10, wherein the ablation head is configured to be positioned within a field of view of the distal end of the endoscope.
The surgical instrument assembly of any of Examples 10 through 11, wherein the proximal shaft portion of the surgical instrument extends parallel to the endoscope shaft.
The surgical instrument assembly of any of Examples 10 through 12, wherein the proximal shaft portion of the surgical instrument is in contact with the endoscope shaft, wherein the ablation head is configured to assume a position in which the ablation head is spaced apart from the endoscope shaft.
The surgical instrument assembly of any of Examples 10 through 13, wherein the ablation head includes a first surface that faces toward the endoscope shaft and an opposed second surface that faces away from the endoscope shaft, wherein the at least one electrode is disposed on the second surface.
The surgical instrument assembly of any of Examples 10 through 14, wherein the endoscope further comprises a handle from which the endoscope shaft extends distally, wherein the endoscope shaft and the surgical instrument are rotatable together relative to the handle about a longitudinal axis defined by the endoscope shaft.
A surgical instrument assembly comprising: (a) an endoscope, wherein the endoscope includes an elongate shaft having a distal shaft end through which the endoscope is configured to capture an image of patient anatomy; and (b) an RF ablation instrument secured relative to the elongate shaft of the endoscope, wherein the RF ablation instrument comprises: (i) a malleable shaft portion, and (ii) an ablation head secured to a distal end of the malleable shaft portion, wherein the ablation head includes at least one electrode operable to ablate patient tissue with RF energy, wherein the ablation head is sized to fit within the nasal cavity of a patient, wherein the malleable shaft portion is configured to bend for selectively orienting the ablation head relative to the distal shaft end of the endoscope.
The surgical instrument assembly of Example 16, wherein the at least one electrode comprises first and second electrodes operable to deliver bipolar RF energy to tissue.
The surgical instrument assembly of any of Examples 16 through 17, wherein a proximal end of the RF ablation instrument includes an electrical connector configured to releasably couple with an RF energy source operable to deliver RF energy to the at least one electrode.
A method of ablating a posterior nasal nerve of a patient with a surgical instrument assembly comprising an endoscope and an RF ablation instrument, wherein the endoscope includes a distal end configured to capture an image of patient anatomy, wherein the RF ablation instrument is secured to the endoscope and includes a malleable shaft portion and an ablation head having an electrode, the method comprising: (a) bending the malleable shaft portion of the RF ablation instrument to position the ablation head within a field of view of the distal end of the endoscope; (b) inserting the distal end of the endoscope and the ablation head into a nasal cavity of a patient; (c) under visualization provided by the endoscope, positioning the electrode of the ablation head in electrical contact with tissue overlying a posterior nasal nerve of the patient; and (d) energizing the electrode with RF energy to thereby ablate a portion of the posterior nasal nerve with the RF energy.
The method of Example 19, wherein the ablation head includes first and second electrodes, wherein ablating the posterior nasal nerve with RF energy comprises positioning the first and second electrodes in electrical contact with the tissue overlying the posterior nasal nerve and delivering bipolar RF energy to the tissue.
IV. Miscellaneous
It should be understood that any one or more of the teachings, expressions, embodiments, examples, etc. described herein may be combined with any one or more of the other teachings, expressions, embodiments, examples, etc. that are described herein. The above-described teachings, expressions, embodiments, examples, etc. should therefore not be viewed in isolation relative to each other. Various suitable ways in which the teachings herein may be combined will be readily apparent to those of ordinary skill in the art in view of the teachings herein. Such modifications and variations are intended to be included within the scope of the claims.
It should be appreciated that any patent, publication, or other disclosure material, in whole or in part, that is said to be incorporated by reference herein is incorporated herein only to the extent that the incorporated material does not conflict with existing definitions, statements, or other disclosure material set forth in this disclosure. As such, and to the extent necessary, the disclosure as explicitly set forth herein supersedes any conflicting material incorporated herein by reference. Any material, or portion thereof, that is said to be incorporated by reference herein, but which conflicts with existing definitions, statements, or other disclosure material set forth herein will only be incorporated to the extent that no conflict arises between that incorporated material and the existing disclosure material.
Versions of the devices described above may have application in conventional medical treatments and procedures conducted by a medical professional, as well as application in robotic-assisted medical treatments and procedures. By way of example only, various teachings herein may be readily incorporated into a robotic surgical system such as the DAVINCI™ system by Intuitive Surgical, Inc., of Sunnyvale, Calif. Similarly, those of ordinary skill in the art will recognize that various teachings herein may be readily combined with various teachings of any of the following: U.S. Pat. No. 5,792,135, entitled “Articulated Surgical Instrument For Performing Minimally Invasive Surgery With Enhanced Dexterity and Sensitivity,” issued Aug. 11, 1998, the disclosure of which is incorporated by reference herein; U.S. Pat. No. 8,783,541, entitled “Robotically-Controlled Surgical End Effector System,” issued Jul. 22, 2014, the disclosure of which is incorporated by reference herein; U.S. Pat. No. 8,479,969, entitled “Drive Interface for Operably Coupling a Manipulatable Surgical Tool to a Robot,” issued Jul. 9, 2013; U.S. Pat. No. 8,800,838, entitled “Robotically-Controlled Cable-Based Surgical End Effectors,” issued Aug. 12, 2014, the disclosure of which is incorporated by reference herein; and/or U.S. Pat. No. 8,573,465, entitled “Robotically-Controlled Surgical End Effector System with Rotary Actuated Closure Systems,” issued Nov. 5, 2013, the disclosure of which is incorporated by reference herein.
Versions of the devices described above may be designed to be disposed of after a single use, or they can be designed to be used multiple times. Versions may, in either or both cases, be reconditioned for reuse after at least one use. Reconditioning may include any combination of the steps of disassembly of the device, followed by cleaning or replacement of particular pieces, and subsequent reassembly. In particular, some versions of the device may be disassembled, and any number of the particular pieces or parts of the device may be selectively replaced or removed in any combination. Upon cleaning and/or replacement of particular parts, some versions of the device may be reassembled for subsequent use either at a reconditioning facility, or by a user immediately prior to a procedure. Those skilled in the art will appreciate that reconditioning of a device may utilize a variety of techniques for disassembly, cleaning/replacement, and reassembly. Use of such techniques, and the resulting reconditioned device, are all within the scope of the present application.
By way of example only, versions described herein may be sterilized before and/or after a procedure. In one sterilization technique, the device is placed in a closed and sealed container, such as a plastic or TYVEK bag. The container and device may then be placed in a field of radiation that can penetrate the container, such as gamma radiation, x-rays, or high-energy electrons. The radiation may kill bacteria on the device and in the container. The sterilized device may then be stored in the sterile container for later use. A device may also be sterilized using any other technique known in the art, including but not limited to beta or gamma radiation, ethylene oxide, or steam.
Having shown and described various embodiments of the present invention, further adaptations of the methods and systems described herein may be accomplished by appropriate modifications by one of ordinary skill in the art without departing from the scope of the present invention. Several of such potential modifications have been mentioned, and others will be apparent to those skilled in the art. For instance, the examples, embodiments, geometrics, materials, dimensions, ratios, steps, and the like discussed above are illustrative and are not required. Accordingly, the scope of the present invention should be considered in terms of the following claims and is understood not to be limited to the details of structure and operation shown and described in the specification and drawings.
This application claims the benefit of U.S. Provisional Pat. App. No. 62/806,009, entitled “Instrument for Endoscopic Posterior Nasal Nerve Ablation,” filed Feb. 15, 2019, the disclosure of which is incorporated by reference herein.
Number | Name | Date | Kind |
---|---|---|---|
5078716 | Doll | Jan 1992 | A |
5733282 | Ellman et al. | Mar 1998 | A |
5792135 | Madhani et al. | Aug 1998 | A |
6045549 | Smethers, II | Apr 2000 | A |
6109268 | Thapliyal et al. | Aug 2000 | A |
6139545 | Utley et al. | Oct 2000 | A |
6210355 | Edwards et al. | Apr 2001 | B1 |
6361531 | Hissong | Mar 2002 | B1 |
6416512 | Ellman et al. | Jul 2002 | B1 |
6447510 | Ellman et al. | Sep 2002 | B1 |
6526318 | Ansarinia | Feb 2003 | B1 |
6562036 | Ellman et al. | May 2003 | B1 |
6572613 | Ellman et al. | Jun 2003 | B1 |
6911027 | Edwards et al. | Jun 2005 | B1 |
6920883 | Bessette et al. | Jul 2005 | B2 |
7001380 | Goble | Feb 2006 | B2 |
7004941 | Tvinnereim et al. | Feb 2006 | B2 |
7297143 | Woloszko et al. | Nov 2007 | B2 |
7377918 | Amoah | May 2008 | B2 |
7491200 | Underwood | Feb 2009 | B2 |
7720521 | Chang et al. | May 2010 | B2 |
7842034 | Mittelstein et al. | Nov 2010 | B2 |
7862560 | Marion | Jan 2011 | B2 |
7892230 | Woloszko | Feb 2011 | B2 |
8290582 | Lin et al. | Oct 2012 | B2 |
8298243 | Carlton et al. | Oct 2012 | B2 |
8479969 | Shelton, IV | Jul 2013 | B2 |
8512335 | Cheng et al. | Aug 2013 | B2 |
8573465 | Shelton, IV | Nov 2013 | B2 |
8747401 | Gonzalez et al. | Jun 2014 | B2 |
8783541 | Shelton, IV et al. | Jul 2014 | B2 |
8800838 | Shelton, IV | Aug 2014 | B2 |
8900227 | Stierman | Dec 2014 | B2 |
8936594 | Wolf et al. | Jan 2015 | B2 |
8961510 | Alshemari | Feb 2015 | B2 |
8979842 | McNall, III et al. | Mar 2015 | B2 |
9011428 | Nguyen et al. | Apr 2015 | B2 |
9072597 | Wolf et al. | Jul 2015 | B2 |
9393067 | van der Burg | Jul 2016 | B2 |
9415194 | Wolf et al. | Aug 2016 | B2 |
9474915 | Gonzales et al. | Oct 2016 | B2 |
9532796 | DuBois et al. | Jan 2017 | B2 |
9649144 | Aluru et al. | May 2017 | B2 |
9687288 | Saadat | Jun 2017 | B2 |
10028781 | Saadat | Jul 2018 | B2 |
11602260 | Saadat | Mar 2023 | B2 |
20030208250 | Edwards et al. | Nov 2003 | A1 |
20040204747 | Kemeny et al. | Oct 2004 | A1 |
20050283148 | Janssen et al. | Dec 2005 | A1 |
20060004323 | Chang et al. | Jan 2006 | A1 |
20060052776 | Desinger et al. | Mar 2006 | A1 |
20060178670 | Woloszko et al. | Aug 2006 | A1 |
20070027451 | Desinger et al. | Feb 2007 | A1 |
20070073282 | McGaffigan et al. | Mar 2007 | A1 |
20070118104 | Wallace | May 2007 | A1 |
20080027423 | Choi et al. | Jan 2008 | A1 |
20080027505 | Levin et al. | Jan 2008 | A1 |
20090012513 | Utley | Jan 2009 | A1 |
20100030031 | Goldfarb | Feb 2010 | A1 |
20100274164 | Juto | Oct 2010 | A1 |
20110160740 | Makower et al. | Jun 2011 | A1 |
20110288412 | Deckman | Nov 2011 | A1 |
20120029498 | Branovan | Feb 2012 | A1 |
20120101494 | Cadouri et al. | Apr 2012 | A1 |
20120316557 | Sartor et al. | Dec 2012 | A1 |
20140100557 | Bohner et al. | Apr 2014 | A1 |
20140324037 | Hoey et al. | Oct 2014 | A1 |
20140364725 | Makower | Dec 2014 | A1 |
20150150624 | Petersohn | Jun 2015 | A1 |
20160058495 | Twomey | Mar 2016 | A1 |
20160058500 | Sharp et al. | Mar 2016 | A1 |
20160256181 | Allen, IV et al. | Sep 2016 | A1 |
20160331459 | Townley et al. | Nov 2016 | A1 |
20170165459 | Gross et al. | Jun 2017 | A1 |
20170197075 | Van Bruggen et al. | Jul 2017 | A1 |
20170231474 | Saadat | Aug 2017 | A1 |
20180078327 | Lin et al. | Mar 2018 | A1 |
20180103994 | Fox et al. | Apr 2018 | A1 |
20180116711 | Suh | May 2018 | A1 |
20180133460 | Townley et al. | May 2018 | A1 |
20180177541 | Regadas | Jun 2018 | A1 |
20180177546 | Dinger et al. | Jun 2018 | A1 |
20180193052 | Govari et al. | Jul 2018 | A1 |
20180228533 | Wolf et al. | Aug 2018 | A1 |
20180263678 | Saadat | Sep 2018 | A1 |
20190374280 | Salazar et al. | Dec 2019 | A1 |
20200000516 | Branovan | Jan 2020 | A1 |
Number | Date | Country |
---|---|---|
1222843 | Jul 1999 | CN |
1224338 | Jul 1999 | CN |
1049413 | Nov 2000 | EP |
1189543 | Mar 2002 | EP |
1416870 | May 2004 | EP |
3027133 | Jun 2016 | EP |
3030183 | Jun 2016 | EP |
3157454 | Apr 2017 | EP |
3258864 | Dec 2017 | EP |
2545559 | Jun 2017 | GB |
WO 1999003411 | Jan 1999 | WO |
WO 1999020185 | Apr 1999 | WO |
WO 1999030655 | Jun 1999 | WO |
WO 2001012089 | Feb 2001 | WO |
WO 2008079476 | Jul 2008 | WO |
WO 2011005903 | Jan 2011 | WO |
WO 2011025830 | Mar 2011 | WO |
WO 2018075273 | Apr 2018 | WO |
Entry |
---|
Heathline, Esophagus, 2018 (Year: 2018). |
E Papesch, The nasal pyriform aperture and its importance, 2016 (Year: 2016). |
Healthline, Esophagus, (Year: 2018). |
International Search Report and Written Opinion dated May 18, 2020 for International Application No. PCT/IB2020/051091, 19 pages. |
Fukutake, Tomoshige, et al. “Laser surgery for allergic rhinitis.” Archives of Otolaryngology—Head & Neck Surgery 112.12 (1986): 1280-1282. |
Gindros, George, et al. “Mucosal changes in chronic hypertrophic rhinitis after surgical turbinate reduction.” European archives of oto-rhino-laryngology 266.9 (2009): 1409-1416. |
Ho, Ki-Hong Kevin, et al. “Electromechanical reshaping of septal cartilage.” The Laryngoscope 113.11 (2003): 1916-1921. |
Number | Date | Country | |
---|---|---|---|
20200261149 A1 | Aug 2020 | US |
Number | Date | Country | |
---|---|---|---|
62806009 | Feb 2019 | US |