Instrument guide

Information

  • Patent Grant
  • 6726699
  • Patent Number
    6,726,699
  • Date Filed
    Tuesday, August 15, 2000
    24 years ago
  • Date Issued
    Tuesday, April 27, 2004
    20 years ago
Abstract
An instrument guide that can compensate for surgical instruments that have different outer diameters. The instrument guide includes a shaft that has an inner channel adapted to receive a surgical instrument. The guide also has a leaf that can be deflected relative to the shaft to exert a spring force onto the instrument. The amount of leaf deflection is dependent upon the outer diameter of the surgical instrument.
Description




BACKGROUND OF THE INVENTION




1. Field of the Invention




The present invention relates to an instrument guide for guiding a surgical instrument into a patient.




2. Prior Art




There have been developed various procedures to perform minimally invasive surgery. For example, there have been developed minimally invasive procedures to perform a coronary artery bypass graft (CABG). The minimally invasive CABG procedure can be performed with a robotic system sold by Computer Motion, Inc., the assignee of the present invention, under the trademark ZEUS.




The ZEUS system includes a plurality of robotic arms that can control the movement of surgical instruments inserted through small incisions in the patient. The surgical instruments move in accordance with the movement of handles held by a surgeon. The handles are located at a console that allows the surgeon to view a monitor that is coupled to an endoscope inserted into the patient. The surgeon can perform a surgical procedure by moving the handles and viewing the surgical site displayed by the monitor.




Performing a minimally invasive procedure may require a number of different surgical instruments. Each robotic arm of the ZEUS system has a coupling mechanism that allows instruments to be attached to, and detached from, the arm. The surgeon, or a surgeon assistant can readily replace instruments during a procedure.




The instruments are typically inserted through a trocar that penetrates the body cavity of the patient. The ZEUS system utilizes the incision point of the patient as a pivot point for the robotic arm and the surgical instrument. The system utilizes a software routine that transforms the coordinates of the surgical instruments to stationary world coordinates to provide commands that accurately move the instruments.




An instrument guide may be placed within the trocar to guide the instrument, maintain robotic arm positioning and facilitate instrument exchanges during surgery. The inner diameter of the instrument guide has approximately the same diameter as the outer diameter of the surgical instrument to prevent relative radial movement between the instrument and the guide. Any excessive space between the surgical instrument and the instrument guide may result in a lag between the movement of the handles and the movement of the instrument. This lag may increase the complexity of performing the procedure.




The outer diameter of the surgical instruments may vary from instrument to instrument. Smaller surgical instruments may create an undesired space between the instrument and the guide. It would be desirable to provide an instrument guide that can be secured to a variety of surgical instruments each having a different outer diameter.




BRIEF SUMMARY OF THE INVENTION




One embodiment of the present invention is an instrument guide that can be inserted into a patient and guide a surgical instrument. The instrument guide includes a shaft that has an inner channel adapted to receive the surgical instrument. The guide also has a leaf that extends from the shaft. The leaf is adapted to move relative to the shaft when the surgical instrument is inserted into the inner channel.











BRIEF DESCRIPTION OF THE DRAWINGS





FIG. 1

is an illustration of an embodiment of a robotic surgical system of the present invention;





FIG. 2

is a side view of an instrument guide tip of the robotic surgical system;





FIG. 3

is an illustration of the instrument guide used with a manually actuated surgical instrument.











DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT




In general the present invention includes an instrument guide that can compensate for surgical instruments that have different outer diameters. The instrument guide includes a shaft that has an inner channel adapted to receive a surgical instrument. The guide also has a leaf that can be deflected relative to the shaft to exert a spring force onto the instrument. The amount of leaf deflection is dependent upon the outer diameter of the surgical instrument.




Referring to the drawings more particularly by reference numbers,

FIG. 1

shows an embodiment of a robotic surgical system


10


of the present invention. The system


10


may include a surgical instrument


12


that extends through a body cavity


14


of a patient. The instrument


12


may be coupled to a robotic arm


16


. The robotic arm


16


may include a number of active joints


18


that can be activated to move the instrument


12


relative to the patient. The arm


16


may also have one or more passive joints (not shown) that allow the instrument


12


to pivot about the incision point of the patient.




The surgical instrument


12


may be connected to a tool driver


20


that can both spin the instrument


12


and actuate an instrument end effector


22


. The tool driver


20


can be configured to allow an operator to readily connect and disconnect the instrument


12


from the driver


20


.




The robotic arm


16


and tool driver


20


can be actuated in accordance with the manipulation of handles (not shown) by the surgeon. Such a system may be the same or similar to a robotic system sold by Computer Motion, Inc. under the trademark ZEUS and disclosed in U.S. Pat. No. 6,007,550 issued to Wang et al., which are hereby incorporated by reference.




The surgical instrument


12


may extend through an instrument guide


24


. The instrument guide


24


may extend through a port element such as a trocar


26


that is inserted into the patient. The instrument guide


24


can be used to guide the instrument


12


through the trocar


26


. Although a trocar is shown and described, it is to be understood that the instrument guide


24


can be inserted through a cannula or other port element.




Referring to

FIG. 2

, the instrument guide


24


may include a guide tip


28


which has a plurality of leaves


30


that extend from a shaft


32


. By way of example, the guide tip


28


may have a plurality of leaves


30


. The shaft


32


may have an inner channel


34


that is adapted to receive the surgical instrument


12


. A proximal end of the tip


28


may have a bore


36


that can be pressed into an end of a tube


38


portion of the guide


24


that extends through the trocar


26


as shown in FIG.


1


. The guide tube


38


may be attached to the tool driver


20


.




Referring again to

FIG. 2

, the leaves


30


are separated by slots


40


. The slots


40


allow the leaves


30


to be deflected in an outward direction when the instrument


12


is inserted through the inner channel


34


. The amount of deflection is dependent upon the outer diameter of the surgical instrument


12


. The leaves


30


exert a spring force onto the surgical instrument


12


to prevent radial movement between the instrument


12


and the guide


24


. The deflecting leaves


30


compensate for various instrument outer diameters while securing the instrument at the pivot point of the system. Each leaf


30


may have an inner tapered portion


42


and a lip


44


configured to reduce the difficulty of retracting the instrument


12


from the guide


24


.




While certain exemplary embodiments have been described and shown in the accompanying drawings, it is to be understood that such embodiments are merely illustrative of and not restrictive on the broad invention, and that this invention is not limited to the specific constructions and arrangements shown and described, since various other modifications may occur to those ordinarily skilled in the art.




For example, although the instrument guide


24


is shown inserted into a trocar and attached to a robotic arm, as shown in

FIG. 3

the guide


24


′ can be inserted into the body cavity


14


without a trocar. Additionally, the surgical instrument


12


′ may be a manually actuated device that is not attached to a robotic arm. In this embodiment the instrument guide


24


′ is configured as a trocar that can be inserted into a patent.



Claims
  • 1. An instrument guide that can be inserted into a patient and guide a surgical instrument that has a diameter, comprising:a shaft that has an inner channel; and, a plurality of leaves that extend from said shaft, said leaves being separated by a space having an inner diameter that is smaller than the diameter of the surgical instrument so that said leaves move when the surgical instrument is inserted into the inner channel, each leaf has a tapered portion and a lip.
  • 2. The instrument guide of claim 1, wherein said leaves are separated by a plurality of slots.
  • 3. The instrument guide of claim 1, wherein said leaves exert a spring force on the surgical instrument.
  • 4. An instrument guide assembly that can be inserted into a patient and support a surgical instrument that has a diameter, comprising:a port element that has an inner channel; and an instrument guide that can be inserted into said inner channel of said port element, said instrument guide having a shaft that has an inner channel, and a plurality of leaves that extend from said shaft, said leaves being separated by a space having an inner diameter that is smaller than the diameter of the surgical instrument so that said leaves move relative to said shaft when the surgical instrument is, inserted into the inner channel, each leaf has a tapered portion and a lip.
  • 5. The assembly of claim 4, wherein said leaves are separated by a plurality of slots.
  • 6. The assembly of claim 4, wherein said leaves exert a spring force on the surgical instrument.
  • 7. The assembly of claim 4, wherein said port element is a trocar.
  • 8. The assembly of claim 4, wherein said port element is a cannula.
  • 9. A trocar that can guide a surgical instrument that has a diameter, comprising:a shaft that has an inner channel and, a plurality of leaves that extend from said shaft, said leaves being separated by a space having an inner diameter that is smaller than the diameter of the surgical instrument so that said leaves move relative to said shaft when the surgical instrument is inserted into the inner channel, each leaf has a tapered portion and a lip.
  • 10. The trocar of claim 9, wherein said-leaves are separated by a plurality of slots.
US Referenced Citations (207)
Number Name Date Kind
977825 Murphy Dec 1910 A
3171549 Orloff Mar 1965 A
3280991 Melton et al. Oct 1966 A
4058001 Waxman Nov 1977 A
4128880 Cray, Jr. Dec 1978 A
4221997 Flemming Sep 1980 A
4367998 Causer Jan 1983 A
4401852 Noso et al. Aug 1983 A
4456961 Price et al. Jun 1984 A
4460302 Moreau et al. Jul 1984 A
4474174 Petruzzi Oct 1984 A
4491135 Klein Jan 1985 A
4503854 Jako Mar 1985 A
4517963 Michel May 1985 A
4523884 Clement et al. Jun 1985 A
4586398 Yindra May 1986 A
4604016 Joyce Aug 1986 A
4616637 Caspari et al. Oct 1986 A
4624011 Watanabe et al. Nov 1986 A
4633389 Tanaka et al. Dec 1986 A
4635292 Mori et al. Jan 1987 A
4641292 Tunnell et al. Feb 1987 A
4655257 Iwashita Apr 1987 A
4672963 Barken Jun 1987 A
4676243 Clayman Jun 1987 A
4728974 Nio et al. Mar 1988 A
4762455 Coughlan et al. Aug 1988 A
4791934 Brunnett Dec 1988 A
4791940 Hirschfeld et al. Dec 1988 A
4794912 Lia Jan 1989 A
4815006 Anderson et al. Mar 1989 A
4815450 Patel Mar 1989 A
4837734 Ichikawa et al. Jun 1989 A
4852083 Niehaus et al. Jul 1989 A
4853874 Iwamoto et al. Aug 1989 A
4854301 Nakajima Aug 1989 A
4860215 Seraji Aug 1989 A
4863133 Bonnell Sep 1989 A
4883400 Kuban et al. Nov 1989 A
4930494 Takehana et al. Jun 1990 A
4945479 Rusterholz et al. Jul 1990 A
4949717 Shaw Aug 1990 A
4954952 Ubhayakar et al. Sep 1990 A
4965417 Massie Oct 1990 A
4969709 Sogawa et al. Nov 1990 A
4969890 Sugita et al. Nov 1990 A
4979933 Runge Dec 1990 A
4979949 Matsen, III et al. Dec 1990 A
4980626 Hess et al. Dec 1990 A
4989253 Liang et al. Jan 1991 A
4996975 Nakamura Mar 1991 A
5019968 Wang et al. May 1991 A
5020001 Yamamoto et al. May 1991 A
5065741 Uchiyama et al. Nov 1991 A
5078140 Kwoh Jan 1992 A
5086401 Glassman et al. Feb 1992 A
5091656 Gahn Feb 1992 A
5097829 Quisenberry Mar 1992 A
5097839 Allen Mar 1992 A
5098426 Sklar et al. Mar 1992 A
5105367 Tsuchihashi et al. Apr 1992 A
5109499 Inagami et al. Apr 1992 A
5123095 Papadopulos et al. Jun 1992 A
5131105 Harrawood et al. Jul 1992 A
5142930 Allen et al. Sep 1992 A
5145227 Monford, Jr. Sep 1992 A
5166513 Keenan et al. Nov 1992 A
5175694 Amato Dec 1992 A
5182641 Diner et al. Jan 1993 A
5184601 Putman Feb 1993 A
5187574 Kosemura et al. Feb 1993 A
5196688 Hesse et al. Mar 1993 A
5201325 McEwen et al. Apr 1993 A
5201743 Haber et al. Apr 1993 A
5217003 Wilk Jun 1993 A
5221283 Chang Jun 1993 A
5228429 Hatano Jul 1993 A
5230623 Guthrie et al. Jul 1993 A
5236432 Matsen, III et al. Aug 1993 A
5251127 Raab Oct 1993 A
5257999 Slanetz, Jr. Nov 1993 A
5271384 McEwen et al. Dec 1993 A
5279309 Taylor et al. Jan 1994 A
5282806 Haber Feb 1994 A
5289273 Lang Feb 1994 A
5289365 Caldwell et al. Feb 1994 A
5299288 Glassman et al. Mar 1994 A
5300926 Stoeckl Apr 1994 A
5303148 Mattson et al. Apr 1994 A
5304185 Taylor Apr 1994 A
5305203 Raab Apr 1994 A
5305427 Nagata Apr 1994 A
5309717 Minch May 1994 A
5313306 Kuban et al. May 1994 A
5320630 Ahmed Jun 1994 A
5337732 Grundfest et al. Aug 1994 A
5339799 Kami et al. Aug 1994 A
5343385 Joskowicz et al. Aug 1994 A
5343391 Mushabac Aug 1994 A
5345538 Narayannan et al. Sep 1994 A
5357962 Green Oct 1994 A
5368015 Wilk Nov 1994 A
5368428 Hussey et al. Nov 1994 A
5371536 Yamaguchi Dec 1994 A
5382885 Salcudean et al. Jan 1995 A
5388987 Badoz et al. Feb 1995 A
5395369 McBrayer et al. Mar 1995 A
5397323 Taylor et al. Mar 1995 A
5402801 Taylor Apr 1995 A
5403319 Matsen, III et al. Apr 1995 A
5408409 Glassman et al. Apr 1995 A
5410638 Colgate et al. Apr 1995 A
5417210 Funda et al. May 1995 A
5417701 Holmes May 1995 A
5422521 Neer et al. Jun 1995 A
5431645 Smith et al. Jul 1995 A
5434457 Josephs et al. Jul 1995 A
5442728 Kaufman et al. Aug 1995 A
5443484 Kirsch et al. Aug 1995 A
5445166 Taylor Aug 1995 A
5451924 Massimino et al. Sep 1995 A
5455766 Scheller et al. Oct 1995 A
5458547 Teraoka et al. Oct 1995 A
5458574 Machold et al. Oct 1995 A
5476010 Fleming et al. Dec 1995 A
5490117 Oda et al. Feb 1996 A
5490843 Hildwein et al. Feb 1996 A
5506912 Nagasaki et al. Apr 1996 A
5512919 Araki Apr 1996 A
5515478 Wang May 1996 A
5544654 Murphy et al. Aug 1996 A
5553198 Wang et al. Sep 1996 A
5562503 Ellman et al. Oct 1996 A
5571110 Matsen, III et al. Nov 1996 A
5572999 Funda et al. Nov 1996 A
5609560 Ichikawa et al. Mar 1997 A
5620456 Sauer et al. Apr 1997 A
5626595 Sklar et al. May 1997 A
5629594 Jacobus et al. May 1997 A
5630431 Taylor May 1997 A
5631973 Green May 1997 A
5636259 Khutoryansky et al. Jun 1997 A
5649956 Jensen et al. Jul 1997 A
5657429 Wang et al. Aug 1997 A
5658250 Blomquist et al. Aug 1997 A
5676673 Ferre et al. Oct 1997 A
5695500 Taylor et al. Dec 1997 A
5696574 Schwaegerle Dec 1997 A
5696837 Green Dec 1997 A
5704900 Dobrovolny et al. Jan 1998 A
5718038 Takiar et al. Feb 1998 A
5727569 Benetti et al. Mar 1998 A
5735290 Sterman et al. Apr 1998 A
5737711 Abe Apr 1998 A
5749362 Funda et al. May 1998 A
5754741 Wang et al. May 1998 A
5762458 Wang et al. Jun 1998 A
5766126 Anderson Jun 1998 A
5776126 Wilk et al. Jul 1998 A
5779623 Bonnell Jul 1998 A
5792135 Madhani et al. Aug 1998 A
5792178 Welch et al. Aug 1998 A
5797900 Madhani et al. Aug 1998 A
5800423 Jensen Sep 1998 A
5807284 Foxlin Sep 1998 A
5807377 Madhani et al. Sep 1998 A
5807378 Jensen et al. Sep 1998 A
5808665 Green Sep 1998 A
5810880 Jensen et al. Sep 1998 A
5813813 Daum et al. Sep 1998 A
5814038 Jensen et al. Sep 1998 A
5817084 Jensen Oct 1998 A
5825982 Wright et al. Oct 1998 A
5827319 Carlson et al. Oct 1998 A
5836869 Kudo et al. Nov 1998 A
5844824 Newman et al. Dec 1998 A
5855583 Wang et al. Jan 1999 A
5859934 Green Jan 1999 A
5860995 Berkelaar Jan 1999 A
5876325 Mizuno et al. Mar 1999 A
5878193 Wang et al. Mar 1999 A
5882206 Gillio Mar 1999 A
5887121 Funda et al. Mar 1999 A
5888190 Meyer et al. Mar 1999 A
5904702 Ek et al. May 1999 A
5906630 Anderhub et al. May 1999 A
5931832 Jensen Aug 1999 A
5950629 Taylor et al. Sep 1999 A
5951475 Gueziec et al. Sep 1999 A
5951587 Qureshi et al. Sep 1999 A
5954731 Yoon Sep 1999 A
5957902 Teves Sep 1999 A
5980782 Hershkowitz et al. Nov 1999 A
5984932 Yoon Nov 1999 A
6024695 Taylor et al. Feb 2000 A
6036641 Taylor et al. Mar 2000 A
6102854 Cartier et al. Aug 2000 A
6113534 Koros et al. Sep 2000 A
6120433 Mizuno et al. Sep 2000 A
6290644 Green, II et al. Sep 2001 B1
6306146 Dinkler Oct 2001 B1
6315718 Sharratt Nov 2001 B1
6331157 Hancock Dec 2001 B2
6371906 Borst et al. Apr 2002 B1
6432121 Jervis Aug 2002 B1
20020014567 King et al. Feb 2002 A1
20020045888 Ramans et al. Apr 2002 A1
Foreign Referenced Citations (12)
Number Date Country
U 9204118.3 Jul 1992 DE
4310842 Jan 1995 DE
0239409 Sep 1987 EP
0424687 May 1991 EP
0776738 Jun 1997 EP
WO 9104711 Apr 1991 WO
WO 9220295 Nov 1992 WO
WO 9313916 Jul 1993 WO
WO 9418881 Sep 1994 WO
WO 9426167 Nov 1994 WO
WO 9715240 May 1997 WO
WO 9825666 Jun 1998 WO
Non-Patent Literature Citations (41)
Entry
“Endocorporeal Surgery Using Remote Manipulators” (Ned S. Rasor and J.W. Spickler) Remotely Manned Systems—Exploration and Operation in Space, California Institute of Technology 1973.
“A Survey Study of Teleoperators, Robotics, and Remote Systems Technology” (Arthur D. Alexander, III) Remotely Manned Systems—Exploration and Operation in Space, California Institute of Technology 1973.
“Impacts of Telemation on Modern Society” (Arthur D. Alexander, III), On the Theory and Practice of Robots and Manipulators vol. II, 1974.
Transcript of a video presented by SRI at the 3rd World Congress of Endoscopic Surgery in Bordeaux on Jun. 18-20, 1992, in Washington on Apr. 9, 1992, and in San Diego, CA on Jun. 4-7, 1992 entitled “Telepresence Surgery—The Future of Minimally Invasive Medicine”.
Statutory Declaration of Dr. Philip S. Green, presenter of the video entitled “Telepresence Surgery—The Future of Minimally Invasive Medicine”.
Abstract of a presentation “Telepresence: Advanced Teleoperator Technology for Minimally Invasive Surgery” (P. Green et al.) given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
Abstract of a presentation “Telepresence: Advanced Teleoperator Technology for Minimally Invasive Surgery”, (P. Green et al.) given at “Medicine meets virtual reality” symposium in San Diego, Jun. 4-7, 1992.
Abstract of a presentation “Camera Control for Laparoscopic Surgery by Speech-Recognizing Robot: Constant Attention and Better Use of Personnel” (Colin Besant et al.) given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
“A Literature Review: Robots in Medicine” (B. Preising et al.) IEEE Jun. 1991.
“Robots for the Operating Room” (Elizabeth Corcoran), The New York Times, Sunday Jul. 19, 1992, Section 3, p. 9, Col. 1.
“Taming the Bull: Safety in a Precise Surgical Robot” (Russell H. Taylor et al.), IEEE 1991.
Abstract of a presentation “Design Considerations of a New Generation Endoscope Using Robotics and Computer Vision Technology” (S.M. Krishnan et al.) given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
Abstract of a presentation “3-D Vision Technology Applied to Advanced Minimally Invasive Surgery Systems” given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
“Analysis of the Surgeon's Grasp for Telerobotic Surgical Manipulation” (Frank Tendick and Lawrence Stark), IEEE 1989.
“Kinematic Control and Visual Display of Redundant Teleoperators” (Hardi Das et al.), IEEE 1989.
“A New System for Computer Assisted Neurosurgery” (S. Lavallee), IEEE 1989.
“An Advanced Control Micromanipulator for Surgical Applications” (Ben Gayed et al.), Systems Science vol. 13 1987.
“Force Feedback-Based Telemicromanipulation for Robot Surgery on Soft Tissues” (A.M. Sabatini et al.), IEEE 1989.
“Six-Axis Bilateral Control of an Articulated Slave Manipulator Using a Cartesian Master Manipulator” (Masao Inoue), Advanced Robotics 1990.
“On a Micro-Manipulator for Medical Application—Stability Consideration of its Bilateral Controller” (S. Majima et al.), Mechatronics 1991.
“Anthropomorphic Remote Manipulator”, NASA Tech Briefs 1991.
“Controlling Remote Manipulators through Kinesthetic Coupling” (A.K. Bejczy), Computers in Mechanical Engineering 1983.
“Design of a Surgeon-Machine Interface for Teleoperated Microsurgery” (Steve Charles M.D. et al.), IEEE 1989.
“A Robot in an Operating Room: A Bull in a China Shop” (J.M. Dolan et al.), IEEE 1987.
Abstract of a presentation “Concept and Experimental Application of a Surgical Robotic System the Steerable MIS Instrument SMI” given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
Abstract of a presentation given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992, entitled “Session 15/1”.
Abstract of a presentation “A Pneumatic Controlled Sewing Device for Endoscopic Application the MIS Sewing Instrument MSI” given at the 3rd World Congress of Endoscopic Surgery in Bordeaux, Jun. 18-20, 1992.
Abstract of a presentation given at the 3rd World Congress of Endoscopic Surgery in Bordeaux (Jun. 18-20, 1992), entitled “Session 15/2”.
Abstract of a presentation given at the 3rd World Congress of Endoscopic Surgery in Bordeaux (Jun. 18-20, 1992), entitled Session 15/4.
Abstract of a presentation given at the 3rd World Congress of Endoscopic Surgery in Bordeaux (Jun. 18-20, 1992), entitled “Session 15/5”.
“Properties of Master-Slave Robots” (C. Vibet), Motor-con 1987.
“A New Microsurgical Robot System for Corneal Transplantation” (Noriyuki Tejima), Precision Machinery 1988.
“Human/Robot Interaction via the Transfer of Power and Information Signals—Part I: Dynamics and Control Analysis” (H. Kazerooni), IEEE 1989.
“Human/Robot Interaction via the Transfer of Power and Information Signals—Part II: An Experimental Analysis” (H. Kazerooni), IEEE 1989.
“Power and Impedance Scaling in Bilateral Manipulation” (J. Edward Colgate), IEEE 1991.
“S.M.O.S.: Stereotaxical Microtelemanipulator for Ocular Surgery” (Aicha Guerrouad and Pierre Vidal), IEEE 1989.
“Motion Control for a Sheep Shearing Robot” (James P. Trevelyan et al.), Proceedings of the 1st International Symposium on Robotics Research, MIT, Cambridge, Massachusetts, USA 1983.
“Robots and Telechirs” (M.W. Thring), Wiley 1983.
Industrial Robotics (Gordon M. Mair), Prentice Hall 1988 (pp. 41-43, 49-50, 54, 203-209 enclosed).
“Student Reference Manual for Electronic Instrumentation Laboratories” (Wolf et al.), Prentice Hall, New Jersey 1990, pp. 498 and 499.
“Surgery in Cyberspace” (Taubes), Discover Magazine, Dec. 1994.