Integrated Digital PCR Platform with a Micromolded Siphoning Array

Information

  • Research Project
  • 9296202
  • ApplicationId
    9296202
  • Core Project Number
    R43OD023028
  • Full Project Number
    5R43OD023028-02
  • Serial Number
    023028
  • FOA Number
    PA-15-052
  • Sub Project Id
  • Project Start Date
    6/15/2016 - 9 years ago
  • Project End Date
    5/31/2018 - 7 years ago
  • Program Officer Name
    CONTRERAS, MIGUEL A.
  • Budget Start Date
    6/1/2017 - 8 years ago
  • Budget End Date
    5/31/2018 - 7 years ago
  • Fiscal Year
    2017
  • Support Year
    02
  • Suffix
  • Award Notice Date
    6/1/2017 - 8 years ago
Organizations

Integrated Digital PCR Platform with a Micromolded Siphoning Array

Abstract Combinati is looking to bring an integrated digital PCR platform with injection molded microfluidic consumables from lab to marketplace to advance the biomedical research. Digital PCR has drawn attentions in both genomic research and clinical research communities for its ability to detect rare events (high sensitivity), less prone to inhibition (high specificity), no need for an internal standard (high precision), and access to well-developed PCR reagents. However, current dPCR instruments are capital intensive, cost per sample is high, and the workflow is complicated. The 2 year Phase 1 SBIR project will allow Combinati to complete the validation of the following key value hypothesis, which will serve as the new product design spec for Phase 2 commercialization effort: 1. Combinati?s unique consumable technology allows high density reagent digitization on a standard format using a scalable manufacturing process. 2. The industry standard format allows integration of pneumatics, thermal, optical, and software modules into one benchtop instrument to offer significant workflow advantage over current commercially available products. 3. Off-the-shelf PCR reagents are compatible with the platform without purchasing of specialized reagents.

IC Name
OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
  • Activity
    R43
  • Administering IC
    OD
  • Application Type
    5
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    350000
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    351
  • Ed Inst. Type
  • Funding ICs
    OD:350000\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    COMBINATI, INC.
  • Organization Department
  • Organization DUNS
    080013010
  • Organization City
    PALO ALTO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    943063638
  • Organization District
    UNITED STATES