Patent Grant
10925697
This application is a U.S. national phase under the provisions of 35 U.S.C. § 371 of International Patent Application No. PCT/KR2016/014586 filed Dec. 13, 2016, which in turn claims priority of Korean Patent Application No. 10-2015-0178843 filed Dec. 15, 2015. The disclosures of such international patent application and Korean priority patent application are hereby incorporated herein by reference in their respective entireties, for all purposes.
The present invention relates to an integrated hybrid dental implant, and more particularly, to an integrated hybrid dental implant in which openings formed at a screw body to enable a drug to be injected into an implantation site of the implant, and the mechanical stability is excellent despite the presence of the openings portion.
A dental implant is a “root” device used in dentistry to support restorations that resemble a tooth or group of teeth to replace missing teeth. The dental implants, abutments, and dental prostheses are collectively called dental restorations or implant systems that resemble a tooth or group of teeth (referred to as “restoration” or “implant system”) as replacements for missing teeth. A dental implant generally appears similar to an actual tooth root and is placed within the bone of the jaw to replace the root of the missing tooth. After the implant surface fuses with the surrounding jaw bone (osseointegration), dental abutments and dental prostheses such as crowns, implant-supported bridges or dentures can be installed. The dental abutments and prostheses then allow a patient to use the restorations for chewing (also called masticatory loading).
The process of placing the dental implants into the jaw bone of a patient is called dental implantation, and it is a very vigorous surgical procedure, resulting in bone damage at the bone-implant interface. A relatively long healing period follows this dental implantation process, which lasts at least about two to three months and may extend to six months. During the healing period, (1) the bone damage is repaired and replaced with new bone tissues (active biological bone remodeling); and (2) direct bone ingrowth or fusion between the implant surface and the bone tissue surrounding the implant is also achieved (osseointegration). If the healing time is too short before any masticatory force is applied on the implant, the implant might risk failure because of the bone damage in the pre-existing interfacial bone, weak new bone tissues, and unstable bone-implant interface with partial osseointegration. The masticatory force applied on an insufficiently healed implant creates excessive micro-motion between bone and implant surface, resulting in fibrous tissue development at the interface which might block further osseointegration and cause eventual failure of the implant system.
To prevent or reduce any possible direct masticatory force being applied on the implant, the installed implant is protected under a healing cap during the healing period. After a sufficient healing period, a second surgery is conducted to install an abutment and a prosthesis (artificial tooth crown). The combination of these two surgeries is frequently used in an implant system that is involved in a dental replacement for the missing tooth.
Most patients who need the dental implantation have various levels of bone deficiency which contribute to intraoral complications that cause tooth loss due to early extraction of teeth or bone loss after the extraction. For example, tooth extraction and disuse atrophy arising from delayed treatment can lead to loss of the alveolar ridge. Segmental oral reconstruction surgeries are likely to result in substantial defects and disconnections in the mandibular bone. The extraction of a posterior maxillary tooth may occasionally make the floor of the maxillary sinus too thin. Sometimes, bone augmentation may not place implants at oral bone sites with too severe bone defects.
Bone grafting surgery is a popular method to treat the bone deficiency in many critical oral defects. Autologous bone has been accepted as an ideal material for grafting allogeneic grafts, which is obtained from human cadavers and animals. However, these bone materials bring the risks of infection and immune rejection. In addition, the degree of bone incorporation or growth through the bone grafting process is uncertain and unclear. Further, many clinical cases have reported post-implantation failures at the bone grafted sites after the bone grafting process. In addition, the grafting for bone augmentations may impose additional surgical steps for patients, increasing the overall treatment costs.
Many studies indicated that growth factors can be introduced to induce bone augmentation, and have suggested bone morphogenetic protein (BMP) as a material having the most potent ability for stimulating bone growth. However, a high BMP dose was shown to cause uncontrolled progress of bone augmentation next to the implant. In addition, a carrier is needed which can contain and deliver BMP molecules. Substantial marginal bone loss adjacent to implants can arise from oral bone disease, including osteoporosis and peri-implantitis under high impact loading of static occlusion and dynamic mastication. Revision surgeries are often required to treat these post-implantation complications. Thus, there is a need for the development of a new implantation strategy that can minimize the additional pre- and post-implantation surgeries.
Korean Patent Laid-Open Publication No. 2014-0143295 discloses a dental implant including an antimicrobial coating layer and a surface treatment method thereof. The invention disclosed in the above-mentioned Korean Patent describes that titania nanotubes are coated on the surface of the implant in order to prevent peri-implantitis, and a drug is adsorbed on the nanotube coating layer in order to avoid peri-implantitis with the aid of the drug eluted after the procedure of the implant. However, the above-described invention has a shortcoming in that the amount of the drug eluted is small to thereby decrease the antimicrobial effects and there may occur adhesion degradation between the implant and the alveolar bone by the nanotube coating.
U.S. Patent Publication No. 20120141955 discloses a hybrid dental implant having a screw body which includes a middle portion having an inner cavity and one or more side openings. The invention disclosed in the above-mentioned U.S. patent describes that a drug is supplied through the side openings to promote bone regeneration around the implant. However, the above-described invention has a drawback in that the side openings have a rectilinear shape to thereby degrade the strength of the implant, and the adhesion between the implant and the alveolar bone is weakened to thereby deteriorate the mechanical stability of the implant.
U.S. Patent Publication No. 20150230889 discloses a hybrid dental implant comprising a screw body having one or more side openings that extend while rotating in a helix-like shape. The invention disclosed in the above-mentioned U.S. patent describes that a drug injected into a middle portion through an open ceiling of an upper portion is supplied through the side openings to thereby accelerate bone regeneration around the implant. However, the above-described invention has a disadvantage in that a tooth connecting portion and the screw body portion are separated from each other by a masticatory impact, and the implant is manufactured in a separation type to decrease the mechanical stability. In addition, the injected drug spreads within a short time of period along with the injection, and as a result, sufficient time required to induce bone cell activation is not ensured.
Accordingly, the present inventors have made extensive efforts in order to solve the above-described problems, have developed a hybrid implant which includes a prosthesis section and a screw body integrally formed with the prosthesis section, the screw body including an upper portion with an open ceiling, a middle portion that is hollow or filled with a drug carrier, and a lower portion with a closed floor, and have implanted the implant, and as a result, have found that a drug can be injected into the area around the implantation site, and the implant has an excellent mechanical stability despite the presence of openings and exhibits more excellent mechanical strength through the integration of the screw body with the prosthesis section, thereby completing the present invention.
It is an object of the present invention to provide an integrated hybrid dental implant which enables a drug to be injected into the implantation site of the implant, has an excellent mechanical stability despite the presence of openings, and allows a screw body to be integrally formed with a prosthesis section to exhibit more excellent mechanical strength.
To achieve the above object, the present invention provides an integrated hybrid dental implant comprising:
(a) a screw body having an external thread formed on an external surface thereof; and
(b) a prosthesis section connected at one side thereof to a tooth prosthesis and integrally configured at the other side thereof with the screw body,
wherein the implant comprises an upper portion with an open ceiling, a middle portion having a hollow inner channel, and a lower portion with a closed floor, and
wherein the hollow inner channel comprises:
(i) an upper end portion connected to the open ceiling, which is configured to receive one or more injectable bone inducing agents;
(ii) a lower end portion terminating at the closed floor; and
(iii) one or more side openings formed to rotate at an angle across a plurality turns of the external thread into a longitudinal direction, the angle being in a range of 30° to 60°, wherein the dimensions of the side openings are designed to enable bone ingrowth into the hollow inner channel of the middle portion or bone outgrowth from the hollow inner channel to the surrounding bone, and the side openings are fluidically connected with the hollow inner channel of the middle portion, and
wherein the hollow inner channel of the implant comprises a drug carrier embedded therein to enable a continuous drug supply.
The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
Unless defined otherwise, all the technical and scientific terms used herein have the same meaning as those generally understood by one of ordinary skill in the art to which the invention pertains. Generally, the nomenclature used herein and the experiment methods, which will be described below, are those well known and commonly employed in the art.
There exists a need to have a dental implant system that allows for simultaneous bone augmentation, and if needed, any post-implantation treatments. The present inventors have developed a hybrid dental implant which includes an open type prosthesis section configured to enable a drug to be injected into an implantation site, and a screw body integrally formed with the prosthesis section, the screw body including an upper portion integrated with the prosthesis section, a middle portion that is hollow or filled with a drug carrier, and a lower portion with a closed floor, and have performed an animal experiment using the hybrid dental implant. As a result, the present inventors have found that the hybrid dental implant is simple, inexpensive, and can induce bone regeneration without additional dental surgeries, and that has an excellent mechanical stability despite the presence of openings.
Therefore, the present invention is directed to an integrated hybrid dental implant comprising:
(a) a screw body having an external thread formed on an external surface thereof; and
(b) a prosthesis section connected at one side thereof to a tooth prosthesis and integrally configured at the other side thereof with the screw body,
wherein implant comprises an upper portion with an open ceiling, a middle portion having a hollow inner channel, and a lower portion with a closed floor, and
wherein the hollow inner channel comprises:
(i) an upper end portion connected to the open ceiling, which is configured to receive one or more injectable bone inducing agents;
(ii) a lower end portion terminating at the closed floor; and
(iii) one or more side openings formed to rotate at an angle across a plurality turns of the external thread into a longitudinal direction, the angle being in a range of 30° to 60°, wherein the dimensions of the side openings are designed to enable bone ingrowth into the hollow inner channel of the middle portion or bone outgrowth from the hollow inner channel to the surrounding bone, and the side openings are fluidically connected with the hollow inner channel of the middle portion, and
wherein the hollow inner channel of the implant comprises a drug carrier embedded therein to enable a continuous drug supply.
The integrated hybrid dental implant according to the present invention allows for injection of the effective bone inducing agents to accelerate bone regeneration, and preferably, bone inducing agents capable of treating oral complications associated with the implant without surgical intervention, while the implant system maintains its role in bearing masticatory loading after the implantation process. The integrated hybrid dental implant has not only a functional scaffold for injecting bone augmentation agents or other medical agents to promote bone regeneration within and around the dental implant during the post-implantation healing period without any additional surgeries, but also functions as a dental implant.
In addition, the integrated hybrid dental implant according to the present invention provides a better long-term mechanical stability of the implant system. For purposes of the present invention, the bone inducing agent can also be referred to as “bone growth factors,” including one or more bone morphogenetic proteins (BMP). Further, a drug carrier can be embedded in the hollow inner channel of the implant to enable a continuous drug supply, if necessary.
The integrated hybrid dental implant according to the present invention may include a screw body having one or more external threads. The screw body integrated with the prosthesis section includes an upper portion with an open ceiling, a middle portion having a hollow inner channel, and a lower portion with a closed floor. The hollow inner channel of the middle portion includes an upper end portion connected to the open ceiling, which is configured to receive one or more injectable bone inducing agents. In one embodiment, additional medical agents can be injected prior to, during, or after dental implantation. Preferably, the hollow inner channel of the middle portion has a diameter ranging from about 0.5 mm to about 2.0 mm, more preferably about 1.0 mm to about 1.5 mm.
The integrated hybrid dental implant according to the present invention a prosthesis section connected at one side thereof to a tooth prosthesis and integrally formed at the other side thereof with the screw body. The prosthesis section is generally screw-engaged to the screw body, but the screw-engagement therebetween may be loosened by a masticatory impact to cause movement of the implant, contributing to peri-implantitis. Thus, preferably, the screw body and the prosthesis section are manufactured in an integrated manner. In addition, the prosthesis section include an inner central channel connected with the middle portion having the hollow inner channel of the screw body so that medicinal agents or bone inducing agents can be injected into an opening formed on one side of the prosthesis section. Further, a drug carrier can be embedded in the hollow inner channel of the implant to enable a continuous drug supply, if necessary.
In the present invention, the side openings extend from the hollow inner channel of the middle portion, rotating at an angle across a plurality turns of the external thread into a longitudinal direction, the angle being in a range of 30° to 60°, preferably 25° to 50°, relative to the turns of the external thread. The dimensions of the side openings may be designed to enable bone or bone tissue ingrowth into the hollow inner channel of the middle portion and bone outgrowth from the hollow inner channel to the surrounding bone. Preferably, the side openings are of a helix-like construction (see
Preferably, the upper portion, the middle portion, and the lower portion of the screw body are located successively along the length of the screw body in a longitudinal direction. The upper portion is integrally connected with the prosthesis section, and may occupy the upper 40% to 50% of the length of the implant other than the prosthesis section. The middle portion adjacent to the upper portion may occupy the middle 40% to 50% of the length of the implant other than the prosthesis section, and the lower portion adjacent to the middle portion may occupy the lower 10% to 20% of the length of the implant other than the prosthesis section.
In the present invention, preferably, the lower portion has a conical shape, and may have one or more self-tapping cuts at a front end thereof.
In the present invention, the upper portion is integrally formed with the prosthesis section. Preferably, the upper portion further comprises a plug-in screw connected to the middle portion having the hollow inner channel to inject bone inducing agents and/or therapeutic agents after the implantation. The plug-in screw serves to block a bacterial infection pathway by an open upper structure after the implantation of the implant, and serves to open the inner channel of the implant, if necessary.
In the present invention, the bone inducing agents preferably include one or more bone morphogenetic proteins. The bone inducing agents are preferably loaded onto a hydrogel, which can then be injected or introduced into the hollow inner channel of the middle portion during and/or after the implantation. The bone inducing agents and/or therapeutic agents can be injected or introduced into the hydrogel after the implantation periodically without additional surgeries. The combination of the loaded hydrogel and the dental implant allows for controlled delivery of bone inducing agents and other therapeutic agents to enable bone regeneration in a controlled fashion to allow for bone ingrowth into the hollow inner channel of the middle portion and bone outgrowth from the hollow inner channel into the surrounding bone. Any carrier other than the hydrogel can be filled in the hollow inner channel.
The present invention provides an integrated hybrid dental implant including a hollow inner channel having one or more side openings, a screw body integrally formed with a prosthesis section having an open top end, a middle portion having the side openings formed therein, and a lower portion. Bone inducing agents and other medication can be introduced into the screw body of the implant through the hollow inner channel, and the bone regeneration or augmentation can be achieved inside of the hollow inner channel through the side openings. Osseointegration of the dental implant progresses from the hollow inner channel to the surrounding bone. The implant may preferably include a screw body having one or more external threads. In this case, the shape of the screw body can be used without limitations. In addition, the implant surfaces may be modified by plasma spraying, anodizing, etching, or sandblasting to increase the surface area and osseointegration potential of the implant.
In the present invention, the integrated hybrid dental implant is installed by integration of the screw body with the prosthesis section 200 at one side thereof. The screw body and the prosthesis section are generally screw-engaged to each other, but the screw-engagement therebetween may be loosened by a masticatory impact to cause movement of the implant, contributing to peri-implantitis. Thus, preferably, the screw body 101 and the prosthesis section 200 are manufactured in an integrated manner. In addition, the prosthesis section include an inner central channel connected with the middle portion having the hollow inner channel of the screw body so that medicinal agents or bone inducing agents can be injected into an opening formed on one side of the prosthesis section. A dental prosthesis is connected to the prosthesis section without any movements using bone cement after the implantation.
In the present invention, Preferably, the body of the dental implant 100 (as shown in
In the present invention, the middle portion 103 may have the hollow inner channel 110 with one or more helix-shaped side openings 106, and the hollow inner channel 110 may extend to the open ceiling. The hollow inner channel 110 is shaped to allow an injectable bone inducing agent to be introduced through the opening ceiling 107 of the upper portion 102 of the screw body 101 into the side openings 106 embedded in the middle portion 103, and the hollow inner channel 110 terminates at the closed floor 108 of the lower portion 104. The hollow inner channel 110 is enveloped by a shell 127, which extends from the outer perimeter 110a of the hollow inner channel 110 (which is an inner surface of the middle portion) to the outer surface 103a of the middle portion 103, which accounts for the thickness of the shell 127. The outer surface 103a of the middle portion 103 is composed of the turns 111 of the external threads 109 and the spaces 111a between the turns of the external threads 109. The diameter of the hollow inner channel (also referred to as the size of the outer perimeter 110a of the hollow inner channel 110) is preferably in a range of about 0.5 to about 2.0 mm, preferably in a range of 1.0 mm to 1.5 mm. The shell 127 may preferably have a thickness of at least about 2 mm to about 5 or 6 mm depending on the size of the implant. A typical dental implant size is about 3.5 mm to 5.0 mm wide and about 10 mm to 15 mm long.
In the present invention, the side openings 106 extend angularly in a radial direction 25 and in a peripheral direction from the hollow inner channel 110 in the middle portion 103, and transverse across a plurality of turns 111 of the external threads 109 at an angle relative to the longitudinal axis 20. Preferably, the side opening 106 rotates around the longitudinal axis 20 in the longitudinal direction 21 in the middle portion 103 at a given angle 113 relative to the longitudinal axis 20, preferably in a range of 25° to 50°, most preferably at 45°, and at an angle 114 relative to the turns 111 of the external threads 109 in a range of 30° to 60°, preferably in a range of 25° to 50°, most preferably at 45°. The two subsequent rotating turns 106a and 106b of the side opening 106 stretch each other in a peripheral direction at an angle 112 in a range of 70° to 100°, preferably at an angle 112 of about 90° (see
That is, the width 115 of the rotating plane is about 0.6 mm or more, or less than 1.5 mm, preferably in the range of 0.7 to 0.9 mm, and in one embodiment, the width 115 is about 0.79 mm. In one embodiment, there is one side opening 106 with multiple turns 106a and 106b, etc., preferably rotating in the middle portion 103 of the screw body 101 in a single-stranded helical manner. In some other embodiments, two or more side openings 106 are formed in a helical shape along the shell 127 of the middle portion.
In the present invention, the dimensions of the side openings 106 are designed such that that they enable the bone inducing agents to induce bone tissue regeneration to promote bone ingrowth through the side openings 106 into the hollow inner channel 110 and bone outgrowth from the hollow inner channel 110 to the surrounding bone so that the bone contact at the implant site can be restored or augmented sufficiently for osseointegration to enable successful implantation of the hybrid implant 100. At the same time, the dimensions of the side openings 106 are designed to maintain the stability of the implant 100 so that the implant 100 can withstand the impact of insertion into the dental implant site and subsequent masticatory loading from chewing.
In the present invention, the side openings are designed to deliver effective agents to induce bone regeneration. It is anticipated that bone ingrowth into the openings occurs while simultaneously integrating the implant threads. The side openings transverse across the implant threads at an angle ranging from 30° to 60° relative to the turns of the thread, the hollow inner channel has a diameter in the range of about 0.5 mm to about 2.0 mm, and sufficient turns and spacing of the implant threads between openings are maintained to allow for bone tissue regeneration while maintaining structural stability to sustain bone implantation.
Moreover, the hybrid implant system can be used for an excellent scaffold or drug delivery device for bone regeneration and other medical treatment during the post-implantation healing period, which will provide a better long-term mechanical stability of the implant system.
The dental implant of the present invention may be made of titanium or other suitable biocompatible materials. Titanium is a preferred material because the bone is observed to adhere to titanium surfaces (“osseointegration”). Suitable titanium can be pure titanium or a titanium alloy. Commercially available pure titanium is divided into four grades depending upon the amount of carbon and iron contained therein. The commercially available titanium alloy is grade 5 titanium, Titanium 6AL-4V (signifying the titanium alloy containing 6% aluminum and 4% vanadium), which offers similar osseointegration levels to that of commercially pure titanium with better tensile strength and fracture resistance.
In the present invention, the implant 100 is intended to be inserted into a bored hole in the jaw bone for permanent anchoring of artificial teeth, tooth bridges and other dental prostheses. The insertion starts with screwing the lower portion 104 of the implant into the bore hole until the entire implant, including the upper portion 102, is screwed into the bore hole of the jaw bone. Preferably, the dental implant have a shape which assist in the insertion of the implant, such as substantially frustoconical, substantially cylindrical (
As used herein, the phrase “outer threaded parts of the implant” can be interchangeably called “the threaded parts of the implant,” “implant threads,” or “screw threads”.
In the present invention, the upper portion 102 has an optional collar and an attachment means for attaching a dental prosthesis thereto. As shown in
In the present invention, the lower portion 104 of the implant may preferably have one or more self-tapping cuts 116 formed at the front end thereof in a tapering conical shape so as to facilitate the insertion of the implant into the bored hole in the bone tissue. The tapering cuts can be longitudinal cavities having cutting faces with cutting edges to provide self-tapping. A cutting edge may have a plurality of cutting teeth. Other suitable types of self-tapping cuts can also be used. In addition, these cutting edges can provide more implant-bone interface areas for osseointegration.
Hereinafter, the present invention will be described in further detail with reference to examples. It will be obvious to a person having ordinary skill in the art that these examples are for illustrative purposes only and are not to be construed to limit the scope of the present invention.
An implant having a size of 03.5×10 mm was manufactured of grade 4 titanium. As shown in
A test of the mechanical strength of the hybrid implant manufactured in the above Example 1 was performed. A new implant was placed on a loading device according to the international standards (ISO 14801) for testing the mechanical strength of the hybrid dental implant.
In addition, for the purpose of comparison, an implant was manufactured in the same manner as in Example 1, except that the side openings are not formed at the hollow inner channel, and the effects of the side openings on the strength of the implant were measured. As shown in Table 1, a static compressive force was applied to the implant placed on the loading device three times until the implant was broken. As shown in
The hybrid dental implant disclosed in U.S. Patent Publication No. 20050230889 was manufactured of grade 4 titanium, and an experiment was performed in the same manner as in the above Experimental Example 1 using the implant manufactured to a size of 03.5×13 mm. One group of implants was installed into a resin, after drilling and tapping the polymer resin (Delrin). The other group of implants were potted using polymethyl methacrylate (PMMA) bone cement that penetrates into the side openings of the implant during curing, which simulates regeneration of bone tissues after bone ingrowth into the hollow inner channel of the implant. A static compressive force was applied to the potted implant until fracture. The PMMA potted group had significantly higher static strength than the Delrin group (p<0.005, n=3 for each group) (
As shown in Table 2, the conventional implant of the Comparative Example 1 suggests that fracture occurred at a connection portion of the implant screw and the prosthesis, and the new hybrid dental implant in Example 1 is 6-fold higher than the conventional implant in Comparative Example 1 in terms of the strength causing the fracture.
This study examined not only the effects of the hybrid dental implant of Example 1 as a functional scaffolding and for the local delivery of an effective dose of BMP and medication loaded in hydrogel, but also whether it can enhance quantity and quality of bone regeneration surrounding the implant implanted.
(1) Experimental Subject
Foxhound dogs (about 2 years old), weighing between 20 and 25 kg were used. All animals in this study were cared for in compliance with NIH publication #85-23 and Guide for the Care and Use of Laboratory Animals. The foxhound dog model has been widely accepted in dental implant- and bone augmentation-related studies.
(2) Experimental Method
The mandibular premolars and first molars were removed and two months of post-extraction healing were allowed. Analgesic and antibiotics were administered to the wound site after exodontia on the day and for three days after the day when the tooth was extracted. In two months after exodontia, following a buccal incision, full-thickness flaps were elevated, and then a hole was formed in the mandible using a trephine drill for implantation and the test group implants and the control group implants were divided into right and left, followed by implantation of three implants of each test group. After implantation of the implants, the cover screws were connected to only the test group implants, and a plastic cap was covered on both the test group implants and the control group implants and the incised site was sutured for closure and allowed to heal. Analgesic and antibiotics were administered to the wound site after surgery on the day and for three days after the day when the surgery was performed, and soft food was supplied for three days after surgery. Then, dry food was supplied for one or two days, and the surgical site was observed at least once at each 24 hours during the raising period of the animals. A total of 23 implants (test group 12, control group 11, Ø3.5 mm×8.5 mm) were used in this test.
Radiography was taken at the implantation sites to record baseline peri-implant bone levels. To label newly formed bone tissue, alizarin red (30 mg/kg) and calcein green (10 mg/kg) were intravenously injected at four and two weeks after surgery, respectively. After three and six weeks of healing, animals were sacrificed via intravenous injection of calcium chloride overdose. The results of the test were shown in
(3) Experimental Results
As shown in
In addition, as shown in
As shown in
As shown in
It can be seen from the results of
The integrated hybrid dental implant according to the present invention enables a drug to be supplied to the area around the implantation site so as to induce bone regeneration in the implant after the implant has been implanted into a bone-deficient site, has an excellent mechanical strength despite the presence of the openings, and allows the screw body to be integrally formed with the prosthesis section to exhibit more excellent mechanical strength so that the implant can be useful as a dental implant.
Although the present invention has been described in detail with reference to the specific features, it will be apparent to those skilled in the art that this description is only for a preferred embodiment and does not limit the scope of the present invention. Thus, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10-2015-0178843 | Dec 2015 | KR | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/KR2016/014586 | 12/13/2016 | WO | 00 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2017/105057 | 6/22/2017 | WO | A |
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| 20150230889 | Kim et al. | Aug 2015 | A1 |
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| Number | Date | Country | |
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| 20180344435 A1 | Dec 2018 | US |
