Patent Application
20150106305
The present invention relates to providing personalized configuration of physical supports for the human body. More particularly, the present invention relates to optimization of physical supports and human positioning to achieve a desired outcome, including reducing the risk of pressure ulcers in general, and reducing the risk of pressure ulcers for people with spinal cord injury (SCI).
This application includes herewith a transmittal under 37 C.F.R §1.52(e) of a Computer Program Listing Appendix on Compact Disk (CD), where the transmittal comprises duplicate compact discs (CDs), totaling two (2) CDs, respectively labeled “Copy 1” and “Copy 2”. Each disk contains the same files. The discs are IBM-PC machine formatted and MICROSOFT WINDOWS Operating System compatible, and include identical copies of the following list of two (2) files, where each file has been saved as a document viewable using MICROSOFT WORD. All of the materials on the compact disk, including the computer program listings contained in the following two (2) files, are incorporated herein by reference in their entirety. The two files are: APPENDIX A—Listing 1 Mobile (61,440 bytes) and APPENDIX B—Listing 2 Mobile-Cloud (366,592 bytes). The referenced listings were created on May 6, 2014.
The Table of Contents for APPENDIX A—Listing 1 Mobile is as follows:
The Table of Contents for APPENDIX B—Listing 2 Mobile-Cloud is as follows:
Negative physiological conditions (e.g., attention deficit, lower back pain, pressure ulcers) may be experienced by people who are seated for long periods of time (e.g., long-haul truck drivers, airline pilots). Pressure ulcers are often experienced by people having compromised mobility (e.g., the elderly and infirm). People inflicted with spinal cord injury (SCI) are particularly prone to developing pressure ulcers. A pressure ulcer is any lesion caused by unrelieved pressure that results in damage of underlying tissue. Pressure ulcers may develop following a prolonged period of compression of the tissue between a bony prominence and a surface.
Unrelieved pressure may result in occlusion of capillaries and lead to ischemia, which has historically been considered a major factor leading to pressure ulcer formation. The cost of treating an individual pressure ulcer ranges up to $40,000 but can exceed $100,000 depending on severity of the wound. Up to 24% of persons residing in nursing homes reportedly have developed a pressure ulcer (also called bed sores). When a person is in a seated position, his or her weight typically rests on a section of the pelvic girdle called the ischial tuberosity (specifically, the inferior, posterior portion of the ischium). There are two of these bony swellings, left and right, sometimes called the sitting bones, which are located on the posterior, inferior portion of the ischium. The gluteus maximus muscle lies over it when a person is standing; however, when he or she sits down, the muscle shifts to a position that exposes the ischium tuberosity, which then bears the majority of the weight, and pressure ulcers may occur.
Pressure ulcers are a frequently occurring healthcare problem throughout the world. Pressure ulcers pose a significant threat to the quality of life for people confined to wheelchairs, such as persons inflicted with spinal cord injury (SCI). Pressure ulcers once formed may lead to sepsis and early death. Pressure ulcers remain the most common secondary condition associated with SCI, and has been reported to occur in from 28% to 85% of patients with SCI, often within a few days of injury. It is estimated that more than half of the SCI population will develop at least one pressure ulcer in their lifetimes. In Europe, treatment of illness associated with pressure ulcers has been estimated to result in up to 4% of total healthcare expenditure. The United States alone spends about $1.4 billion annually on the treatment of pressure ulcers for people with SCI. It has been estimated that the cost of treating pressure ulcers is 2.5 times the cost of preventing them. Considering the numbers and cost of treatment, pressure ulcers are an important public health problem. There is an urgent and growing need to develop effective modes of prevention and treatment.
Although wheelchair tilt and recline functions are typically used for pressure ulcer prevention, present approaches cannot determine at what angles wheelchair tilt and recline provide effective prevention of pressure ulcers. Clinicians typically recommend uniform guidance to all patients. However, clinical evidence clearly shows that the SCI individuals demonstrate a wide variety of requirements. Consequently, universal guidelines cannot satisfy all the needs. Hence, personalized configuration of wheelchair tilt and recline for each individual is more desirable and beneficial.
It is known that traditional statistical methods can be used to model biomedical problems. However, statistical methods are found less capable of finding patterns, dealing with data that may contain noise, or analyzing non-linear and dependent data. Artificial intelligent techniques on machine learning, on the other hand, have played increasingly important role in bioinformatics for classifying and mining data. Such techniques can capture patterns based on examples (i.e., training data) even though the underlying nature, principles, and/or probability distributions may not be clear. It is, therefore, an object of the present invention to use an artificial intelligent module (artificial neural network in the current implementation) to provide a method and apparatus with which to discover patterns driven by individual human conditions, operational environments, and outcome or use objectives. It is a further objective of the present invention to provide personalized guidance and configuration control for seating support, adjustment, and positioning including wheelchair tilt and recline usage for people confined to wheelchairs and who may be inflicted with SCI.
Pressure ulcers (PUs) impose a significant threat to the quality of life of wheelchair users. Prolonged unrelieved seating pressure has been identified as a major causative factor of PUs. Wheelchair tilt and recline (TR) functions are two of the most desirable features on a wheelchair for relieving seating pressure. Tilt refers to a change of the seat angle orientation while maintaining the seat-to-back angle and recline refers to a change of the seat-to-back angle. Despite the importance of TR functions, the majority of the wheelchairs do not offer a built-in mechanism to measure TR angles. Wheelchair users tend to adjust TR angles based on their own perceptions. However, research shows that wheelchair users rarely adjust enough tilt or recline angles to relieve seating pressure, which has been recognized as a major causative factor of pressure ulcers. The reasons for the ineffective usage of wheelchair TR functions are in part due to the lack of a convenient way to measure wheelchair TR angles, and in part due to the lack of a practical way to monitor whether wheelchair users follow the clinical guidelines of wheelchair TR usage.
The present invention enables a user to obtain a set of favorable tilt and recline combinations derived from the user's specific profile that can help reduce the risk of pressure ulcers. A profile may include information comprising the user's age, gender, height, weight, body mass index, level of injury, completeness of injury, duration of injury, age at onset of injury (e.g., SCI, stroke, amputation), whether he/she smokes, drinks alcohol, exercises, and/or has pressure ulcer history. An overall picture of the user's favorable tilt and recline settings are presentable, along with choices to adjust seating positions. Users are also presented with the best TR functions that can most effectively reduce risk of pressure ulcers.
The present invention provides a unique way to effectively use wheelchair TR functions, even though most wheelchairs in use today do not offer a built-in mechanism for measuring TR angles. Smart mobile devices (smartphones and tablets) are configurable using the methods of the present invention to accurately measure TR angles. For example, the advanced computational process of the present invention enables users to conveniently measure wheelchair TR angles by simply positioning a smartphone configured in accordance with the present invention in their pockets (e.g., shirt pocket). Further, through the combined use of mobile and cloud computing, the methods of the present invention enable automatic transmission of wheelchair TR usage information to “cloud-based” storage and remote analysis.
Cloud computing is often defined as the practice of using a network of remote servers hosted on the Internet to store, manage, and process data, rather than a local server or a personal computer. Cloud storage involves storing data on multiple virtual servers that are generally hosted by third parties. The term “cloud” as used herein generally refers to cloud computing, cloud storage, and the World Wide Web. Hence, through the use of cloud computing and web-based approaches, heathcare providers and researchers can effectively monitor whether the TR guidelines are properly carried out in wheelchair users' natural settings (e.g., home, office, community, etc.). The present invention works for both power and manual wheelchairs, provided they are equipped with tilt or tilt and recline functions. Hence, functionality of both new and exising wheelchairs can be significantly improved through use of the present invention.
The present invention may be implemented in multiple non-limiting versions, including a local device (e.g., smartphone) version, a mobile-cloud version, and a web-cloud version. In the local version, all the functionality may be implemented locally in a smartphone, or similar mobile device. This embodiment may be preferable for use by individuals with limited data transfer and bandwidth capacity. However, a fully localized embodiment implies that the same artificial intelligent module will have to be implemented multiple times for different mobile operating systems, such as Android, iOS, and Windows. Alternative embodiments may be preferable for users where data transfer and bandwidth capacity is sufficient. The artificial intelligent module and data storage may be extracted from the local version and implemented as a cloud computing model in the Internet cloud. In this embodiment, only one implementation of the intelligent module is needed, and both the artificial intelligent module and the data storage may be accessed from a mobile device or a web-based user interface. The smartphone application as well as the web application are responsible for collecting user's information, requesting guidance on wheelchair tilt and recline usage or other position parameters, displaying results to the users, and using a goniometer implemented on the local device to measure wheelchair tilt and recline angles.
In a broad aspect, the apparatus of the present invention accepts input that may comprise an individual's demographic information, neurological attributes, physical history, operational environment, and outcome or use objectives, then returning guidance and/or control parameters directed to positioning and adjustment of physical supports for the human body.
In another aspect, the present invention may be embodied as a specific purpose mobile device comprising a computational framework, artificial neural network, a goniometer, and minimum functionality necessary for configuration and control of positioning and adjustment directed to seating supports for the human body.
In another aspect, the present invention provides functions and analytical processes capable of finding patterns, dealing with data that may contain noise, or analyzing non-linear and dependent data.
In yet another aspect, the present invention may be embodied as a specific purpose device integrated into a powered seating apparatus, where the device comprises a computational framework, artificial neural network, a goniometer, and minimum functionality necessary for configuration and control of seating support configuration.
In another aspect, the present invention may comprise a computational framework, artificial neural network, and application instruction set operable on mainstream general purpose mobile devices including “smartphones” (e.g. iPhone 5, Samsung Galaxy), tablets computers (e.g., iPad), Google glass, iWatch, etc., collectively “smart devices,” running operating systems such as Android, iOS, and MS-Windows, where such devices include at least an accelerometer.
In another aspect, the artificial neural network in the present invention is embodied as an artificial intelligence (AI) module trained with clinical research data directed to optimal positioning and adjustment of physical supports for the human body for a defined purpose or desired outcome.
In another broad aspect, the apparatus of the present invention accepts input comprising an individual's demographic information, neurological attributes, and pressure ulcer history and provides guidance or control parameters directed to: (1) the favorable wheelchair tilt and recline settings; (2) the optimal wheelchair tilt and recline angles that may most effectively reduce pressure ulcer risks; and (3) the measurement of tilt and recline angles by implementing a goniometer.
In another aspect, the present invention may be configured to provide optimal duration and frequency to perform wheelchair tilt and recline functions in response to input comprising an individual's demographic information, neurological attributes, and pressure ulcer history.
In another aspect, the present invention may be configured to measure wheelchair tilt and recline angles (i.e., a goniometer), periodically remind the wheelchair user of performing wheelchair tilt and recline, record wheelchair tilt and recline usage information, including the time when the wheelchair user performs the tilt and recline functions, the angles of the tilt and recline, the duration on which the user maintains the tilt and recline position, and the derived frequency, i.e., how often the wheelchair user repositions himself/herself by means of wheelchair tilt and recline.
In another aspect, the goniometer can work independently of the artificial neural network and intelligent module, and operable on mainstream general purpose mobile devices including “smartphones” (e.g. iPhone 5, Samsung Galaxy), tablets computers (e.g., iPad), Google glass, iWatch, etc., collectively “smart devices,” running operating systems such as Android, iOS, and MS-Windows, where such devices include at least an accelerometer.
In another broad aspect, the present invention may be embodied as a specific purpose mobile device comprising a computational framework, artificial neural network, a goniometer, and minimum functionality necessary for configuration and control of wheelchair tilt and recline.
In yet another aspect, the present invention may be embodied as a specific purpose device integrated into a powered wheelchair, where the device comprises a computational framework, artificial neural network, a goniometer, and minimum functionality necessary for configuration and control of wheelchair tilt and recline.
In another aspect, the present invention may comprise a computational framework, artificial neural network, and application instruction set operable on mainstream general purpose mobile devices including “smartphones” (e.g. iPhone 5, Samsung Galaxy), tablets computers (e.g., iPad), Google glass, iWatch, etc., collectively “smart devices,” running operating systems such as Android, iOS, and Windows, where such devices include an accelerometer.
In another broad aspect, the present invention combines mobile computing and artificial intelligence techniques, incorporating an artificial intelligence (AI) module in an application instruction set operable on a mobile device.
In another aspect, the AI module may be trained with clinical research data on clinically recommended tilt and recline angles, and other position parameters.
In another aspect, smart device users may input into the user interface of the present invention their demographic, neurological, and pressure ulcer history information, and recommended wheelchair tilt and recline angles will be determined favorable for the individual to reduce risk of pressure ulcers.
In another aspect of the present invention, the user interface of the present invention may be configured to display the recommended wheelchair tilt and recline angles, or other position parameters.
In another aspect of the present invention, recommended wheelchair tilt and recline angle may be output from a mobile embodiment of the present invention to a control function operating in a powered wheelchair or other powered mobility device.
In another aspect of the present invention, recommended wheelchair tilt and recline angle may be transferred wirelessly to a controller operational to adjust configuration orientation of a powered wheelchair or other powered mobility device.
In a yet another broad aspect of the present invention, an artificial intelligent module is provided comprising an artificial neural network (ANN) having a layered network structure, in which processing units (i.e., neurons) are arranged in layers, where the neurons in adjacent layers can communicate with each other by sending and receiving signals through weighted connections.
In another aspect, the input/output behavior of a neuron is defined by its internal activation function, which accumulates the input signals and then calculates the outputs.
In another aspect, a learning process proceeds in iterations by tuning the weights of connections using a training algorithm (e.g., the back-propagation algorithm).
In another aspect, a user registration component is provided, which allows users to create their own profiles to record their demographic information (e.g., gender, weight, height, etc.), neurological information (e.g., level of injury, completeness of injury, etc.), and pressure ulcer history (i.e., whether he/she once developed pressure ulcers).
In another aspect of the present invention, the output includes (1) a range of tilt and recline angles that are favorable for pressure reduction for the user; and (2) the optimal tilt and recline angles that are most effective in reducing the risk of pressure ulcers.
In another aspect, the present invention may be configured to provide optimal frequency and duration to perform wheelchair tilt and recline functions, including guidance such as “perform tilt and recline every 15 minutes (i.e., frequency) and maintain the tilt and recline setting for at least 3 minutes (i.e., duration).”
In another aspect of the present invention, a goniometer is provided, which uses an accelerometer sensor in a smart device (e.g., smartphone or tablet) to measure angles of wheelchair tilt and recline.
In another aspect of the present invention, a goniometer measures current wheelchair tilt and recline angle and contrasts those angles with guidance angles to generate control parameters that cause the tilt and recline angle of a powered wheelchair or other powered mobility device to be rotated to a precise angular position.
In another aspect of the present invention, a goniometer may be configured to periodically remind the wheelchair user of performing wheelchair tilt and recline, and record wheelchair tilt and recline usage information, including the time when the wheelchair user performs the tilt and recline functions, the angles of the tilt and recline, the duration on which the user maintains the tilt and recline position, and the derived frequency, i.e., how often the wheelchair user repositions himself/herself by means of wheelchair tilt and recline.
In another aspect of the present invention, the goniometer utilizes advanced math and physics methods to establish a model of the mobile device, which is able to accurately measure wheelchair TR angles no matter how the user positions the mobile device. As a result, the wheelchair user can place the smartphone into his/her pocket while accurately measuring the tilt and recline angles.
In another aspect of the present invention, a goniometer uses voice alerts to guide the usage of wheelchair tilt and recline. As a result, the wheelchair user can place the smartphone into his/her pocket while measuring the tilt and recline angles.
In another aspect of the present invention, a goniometer can work independently without relying on the artificial neural network and intelligent module.
In another aspect of the present invention, the network structure and weights of the artificial neural network are determined offline by using clinical research data on clinically recommended tilt and recline angles, or other position parameters.
In another aspect of the present invention, the artificial neural network is fully configurable through adjusting the network structure and weights.
In another aspect of the present invention, the artificial neural network operable in the AI module can be replaced by other artificial intelligence techniques, namely, any classification, clustering, and regression techniques.
In another broad aspect, the present invention is operable in a mobile-to-cloud configuration, where the AI module is implemented in a cloud computing platform, and the use of cloud-computing (“the cloud”) will enable smart devices running on different operating systems to share the same AI module in the cloud.
In another aspect of the present invention, where the AI module is operable in the cloud, the smart device will be responsible for at least collecting user's information, requesting guidance on wheelchair tilt and recline usage or other position parameters, displaying results to the users, and using an implemented goniometer to measure wheelchair tilt and recline angles, balancing workload between mobile and cloud and simplifying maintenance and upgrade.
In another aspect of the present invention, where the AI module is operable in the cloud, the smart device may output adjustment parameters to a control device operational in a powered seating apparatus (e.g. powered wheelchair).
In another broad aspect, the present invention provides actionable aural guidance to achieve recommended tilt and recline settings suitable to a particular wheelchair user based on his/her own profile.
In another aspect, the present invention enables measurement, display, and auditory notification of tilt and recline angles in near real-time as a user adjusts tilt and recline settings on a wheelchair.
In another aspect, the present invention provides remote monitoring and analytics as to whether or not wheelchair users follow recommended tilt and recline guidance.
In another broad aspect of the present invention, a goniometer measures current user positioning angles and contrasts those angles with clinical guidance to generate control parameters that cause the seating position of a powered seating apparatus to be altered to a precise angular position.
In another broad aspect of the present invention, a method is provided for determining spatial orientation of a computational device configured with an accelerometer, comprising: providing a positioning model of said computational device, said positioning model including a vector ν=αx, αy, αz
representing accelerations in three axes measured by said accelerometer; utilizing the dot product property θ=arccos(ν1·ν2/|ν1|×|ν2|) to calculate angle changes between at least two vectors; where dynamic positioning of said computational device is calculated relative to any reference physical orientation.
In another aspect, the present invention includes the computational device implemented on a mobile device configured to measure incline angles which may include tilt and recline angles.
a is a non-limiting diagram showing a screen shot of a smartphone implementation.
b is a non-limiting diagram showing a screen shot of a web-based implementation.
c is a non-limiting diagram showing the structure of a sample artificial neural network.
a) is a non-limiting diagram showing a class diagram for the Google App Engine (GAE, i.e., cloud) configuration where the classes are used to compute personalized guidance on wheelchair tilt and recline usage, and interact with the mobile and web applications.
b) is a non-limiting diagram showing a class diagram for Google App Engine (cloud) configuration of the present invention where the classes are used to store the tilt and recline usage information (the time when the user performs the tilt and recline functions, the angles of the tilt and recline, etc.)
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to access system functions.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to access system functions.
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to enter demographic attributes.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to enter demographic attributes.
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to display favorable tilt and recline angles.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to display favorable tilt and recline angles.
c is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to display the best tilt and recline angles for the user.
d is a non-limiting diagram showing a screen shot of a web-based implementation of the present invention providing a user interface to display the best tilt and recline angle for the user.
In brief:
a is a non-limiting diagram showing a screen shot of a smartphone implementation for the mobile-to-cloud version. A user can choose “submit” if he/she is an existing user. Otherwise, the user needs to register first.
b is a non-limiting diagram showing a screen shot of a web-based implementation. A user can choose “submit” if he/she is an existing user. Otherwise, the user needs to register first.
c is a non-limiting diagram showing the structure of an artificial neural network. It consists of three layers, which are input layer, hidden layer, and output layer arranged from left to right.
a) is a non-limiting diagram showing a class diagram for a GAE (cloud) configuration where the classes are used to compute personalized guidance on wheelchair tilt and recline usage, and interact with the mobile and web applications. The code structure includes: ApplicationUser, BloodFlowCore, BloodFlowResult, Range, UserEndpoint, CheckAnglesServlet, SignInServlet, ResultEndpoint, UpdateUserServlet, DeleteUserServlet, SignOutServlet, MLP, LinearUnit, NeuralEnd, and NeuralConnection.
b) is a non-limiting diagram showing a class diagram for the GAE (cloud) configuration of the present invention where the classes are used to store the tilt and recline usage information (the time when the user performs the tilt and recline functions, the angles of the tilt and recline, etc.) The code structure includes: AngleData, DataManager, and EMF.
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to access system functions. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to access system functions. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to enter demographic attributes. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to enter demographic attributes. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
a is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to display favorable tilt and recline angles. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
b is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to display favorable tilt and recline angles. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
c is a non-limiting diagram showing a screen shot of a smartphone implementation providing a user interface to display the best tilt and recline angle for a user. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
d is a non-limiting diagram showing a screen shot of a web-based implementation providing a user interface to display the best tilt and recline angle for a user. System responses are anticipated to at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated.
In detail: Referring now to
Referring now to
Referring now to
The preferable output includes (1) a range of tilt and recline angles that are favorable for pressure reduction for the user 31; (2) the optimal tilt and recline angles that are most effective in reducing the risk of pressure ulcers 32; and (3) the optimal frequency and duration to perform wheelchair tilt and recline functions 33.
Referring now to
Referring now to
Referring now to
The network structure and weights of the ANN in the application are determined offline by using clinical research data on clinically recommended tilt and recline angles. Specifically, wheelchair users with spinal cord injury were recruited to participate in the research. A testing condition includes a five-minute sitting-induced ischemic period, i.e., the research participant sits in the upright position with no tilt or recline for 5 minutes, and a five-minute pressure relief period, i.e., the research participant sits in a clinically recommended tilt and recline setting for 5 minutes. The skin blood flow was measured throughout the test so that we can know whether a tilt and recline setting is favorable for increasing skin blood flow, which has been widely used to determine the efficacy of wheelchair seating conditions. Then, the skin blood flow data was used to train the ANN to predict tilt and recline settings for individual wheelchair users. Other position parameters may be incorporated as well, such as the elevating leg-rest function of a power wheelchair. The ANN in the invention is fully configurable through adjusting the network structure 400 and weights. The ANN can be replaced by other artificial intelligence techniques, namely, any classification, clustering, and regression techniques, such as support vector machine (SVM), C4.5 decision tree, random forest, etc. The present invention will support such transparency in changing the AI module.
Referring now to
InitActivity.java: This class 51 shows the welcome screen when the application is loading. It calls ClsTrainner 52 to train the classifiers in the backend. Once it finishes initializing classifiers, this activity class will transfer to the Main 50A activity class.
ClsTrainner.java: This class 52 is used to initialize a classifier and regression learner coded in the present invention. The classifier can classify whether a given tilt and recline setting is favorable for an individual with spinal cord injury (SCI) to reduce the risk of pressure ulcer. The regression learner can predict the extent of risk deduction for a given tilt and recline setting. This class runs in the backend as a thread when the application starts.
Main.java: The Main class 50A is the container for all the fragment classes in this application. It provides the overall layout of the application.
FragmentForm.java: This class 55 is used to provide the user interface to input data 53. Users can update their profiles (
FragmentFrequency.java: This class 56 shows to the users the optimal duration and frequency to perform the wheelchair tilt and recline functions. It invokes the daemon thread that is running in the backend to return the optimal duration and frequency to the user interface (UI) thread.
FragmentList.java: This class 58 provides a list of functions that is offered by the smartphone app. It redirects a user to the appropriate functions based on the user's choice.
FragmentResult.java: This class 59 includes the template of My Range, My Optimal, and My Test screens (shown on
InputData.java: This is a singleton class 53 that it has only a single instance in the memory. It contains all the data in this application. It acts as a data store in this application. The trained functions (classifier and regression) as well as user inputs are all stored in this class.
ResultTask.java: The ResultTask class 54 is running in the backend as a daemon thread. Its functionality is to make predictions based on a user's profile (
FragmentAngleMeter.java: This class 57 provides the goniometer function. It reads the accelerometer sensor in the smartphone and calculates the current angle of the phone orientation for the user. This class provides a novel algorithm to measure wheelchair tilt and recline (TR) angles by using the accelerometer in a smartphone. Specifically, the position of a smartphone is modeled with a vector ν=αx, αy, αz
, which represents accelerations in three axes measured by the accelerometer. When the tilt or recline stabilizes to a new angle, accelerations in three axes will change due to the decomposition of the gravity along the new angle of the phone. Then, we utilize the dot product property to calculate angle changes between two vectors (positions):
ν1·ν2=|ν1|×|ν2|×cos θ (1)
Or equivalently,
θ=arccos(ν1·ν2/|ν1|×|ν2|) (2)
Hence, no matter how the smartphone is positioned, the TR angle θ between two vectors can be measured. In addition, this class employs the novel text-to-speech technique (see class IntentService.java), which enables the system to use voice alerts to guide wheelchair users for proper TR usage.
IntentService.java: This class 571 implements the Android text-to-speech listener and initializes the text-to-speech function for the subsequent usage.
Referring now to
Index Page 61 (index.html): Index page 61 is the first web page that a user can access. It provides options for registered users to sign in and for unregistered users to register.
Register 611 (SignInServlet): It is a Java Servlet that is invoked by index.html and allows unregistered users to register and create their own user names and passwords. A Java servlet is a class that is used to extend the functionality of the cloud.
Sign in 612 (SignInServlet): It is a Java servlet used by index.html when to sign in and register users given a username and password.
User Welcome Page 62 (welcome.jsp): It is the welcome page after a user successfully signs in the system.
Profile Page 621 (profile.jsp): This page allows users to create their own profiles including their demographic attributes, neurological information, and pressure ulcer history, etc.
Update Profile 6211 (UpdateUserServlet): It is a servlet class that is invoked by profile.jsp to update the user's profile.
Check Angle Page 622 (check.jsp): This page gives a user the option to check whether a particular wheelchair tilt and recline setting will be favorable for the individual user to reduce pressure ulcer's risk.
Check Angles 6221 (CheckAnglesServlet): It is a servlet class that is invoked by check.jsp to check whether a particular wheelchair tilt and recline setting will be favorable for the individual user to reduce pressure ulcer risk.
Range of Angles Page 623 (result.jsp): This page shows the range of tilt and recline angles that are favorable for reducing pressure ulcers' risk.
Optimal Angle Page 624 (optimal.jsp): This page shows the optimal wheelchair tilt and recline settings that may most effectively reduce risk of pressure ulcers.
Duration and Frequency Page 625 (duration.jsp): This page illustrates the optimal duration and frequency to perform wheelchair tilt and recline functions. For example, the user should perform wheelchair tilt and recline functions every 15 minutes (i.e., frequency) and each time the user should maintain that setting for 3 minutes (i.e., duration).
Admin User List Page 63 (admin.jsp): This is a page designed for administrators, who will maintain users, including “add”, “edit”, and “delete” users.
Delete User 631 (DeleteUserServlet): It is a Java servlet used by admin.jsp when an administrator attempts to delete an application user.
Edit User Page 632 (edituser.jsp): This is a web page that invokes Servlets to add a new user or update an existing user.
Edit User 64 (UpdateUserServlet): It is a Java servlet used by admin.jsp when an administrator attempts to edit a user's information.
Create New User 65 (UpdateUserServlet): The same UpdateUserServlet can also be used to create a new user.
Referring now to
Login Screen 71 (LoginActivity): It is the starting Android activity that calls register and signin methods and redirects user to the MenuActivity 701 if the user name and password are verified successfully. Activity is an Android term that represents a function that a user can perform.
Register 72: It invokes the Datastore class (Datastore.register function) that interacts with the Google App Engine datastore to store new user's information (see
Datastore 721: This class interacts with the Google App Engine datastore service and is used by both the mobile endpoints and java servlets.
Sign In 73: It invokes the Datastore class (Datastore.signin function) that interacts with the Google App Engine datastore to validate the user's information (see
User Menu Screen 701 (MenuActivity): It is the main activity that shows the main menu of the system. It consists of the currently selected fragment and a navigation list for changing fragments. A fragment is an Android term that represents a portion of the user interface.
Profile Screen 74 (FragmentForm): It is a fragment that consists of the input fields for user information. Once the button at the bottom of the fragment is pressed, the given information is then updated 741 to the datastore in the cloud (see
Check Angle Page 75 (FragmentCheck): It is a fragment that determines if the given tilt and recline angles 751 are in the ranges provided by the artificial neural network (see
Range of Angles Page 76 (FragmentResult): It is a fragment that displays a list of ranges provided by the artificial neural network (see
Optimal Angles Page 77 (FragmentOptimal): It is a fragment that displays the optimal angles of wheelchair tilt and recline provided by the artificial neural network (see
Duration and Frequency Page 78 (FragmentFrequency): It is a fragment used to check the duration and frequency that the user should perform wheelchair tilt and recline functions. For example, the user should perform wheelchair tilt and recline functions in every 15 minutes (i.e., frequency) and each time the user should maintain that position for 3 minutes (i.e., duration).
Goniometer 79 (FragmentAngleAdjustment): It is a fragment used to display the current angle of the phone. It reads the accelerometer sensor in the smartphone and calculates the current angle of the phone orientation for the user. A desired angle can be set by using the device's menu button. The background of this fragment will turn greener the closer the current angle is to the desired angle.
Referring now to
ApplicationUser 81: consists of all user fields and represents the entity structure stored in the Google App Engine (GAE) datastore.
BloodFlowCore 82: contains methods for interacting with the WEKA API, which is an open source data mining platform and returning the BloodFlowResult object. This is where the artificial neural network is built and angles are returned.
BloodFlowResult 83: contains all output results needed and eventually displayed to the user, including a list of tilt and recline ranges, the optimal angles, and duration and frequency.
Range 84: is a class used to hold one set of tilt and recline ranges.
UserEndpoint 85: this Endpoint class manipulates ApplicationUser entities in the datastore by calling the Datastore class methods. Endpoint classes are located in the GAE source code and are annotated to be generated into an API to be used with Android.
CheckAnglesServlet 86: is a servlet class that checks whether a particular wheelchair tilt and recline setting will be favorable for the individual user to reduce pressure ulcer's risk.
SignInServlet 87: is a Java servlet used when to sign in and register users given a username and password.
ResultEndpoint 88: this endpoint creates a BloodFlowResult object to store results from the runBloodFlowCore method. Endpoint classes are located in the GAE source code and are annotated to be generated into an API to be used with Android.
UpdateUserServlet 89: is a Java servlet used when an administrator attempts to edit a user's information.
DeleteUserServlet 810: is a Java servlet used when an administrator attempts to delete an application user.
SignOutServlet 811: This class provides the sign out function in the web application.
MLP.java 812: The MLP class is customized by adding getNumWeights( ), importWeights( ), and exportWeights( ) methods. These methods allow us to reconstruct ANN if the network structure and weights are provided.
MLP 812, LinearUnit 816, NeuralEnd 817, and NeuralConnection 818 are obtained from WEKA, which is an open source platform for data mining. These classes are used to model the artificial neural network. LinearUnit 816, NeuralEnd 817, and NeuralConnection 818 are used without any customizations.
Referring now to
AngleData 813: is the data type class that models tilt and recline angle data, which is sent from the mobile client.
DataManager 814: is the class that handles the communication between the client and Google datastore.
EMF 815: EntityManagerFactory helps communication between the Google datastore and the application.
Referring now to
LoginActivity 91: it is the starting Android activity that calls register and signin methods and redirects user to the MenuActivity 92 if the user name and password are verified successfully. Activity is an Android term that represents a function that a user can perform.
MenuActivity 92: it is the main activity that shows the main menu of the system. It consists of the currently selected fragment and a navigation list for changing fragments. A fragment is an Android term that represents a portion of the user interface.
FragmentForm 921: It is a fragment that consists of the input fields for user information. Once the button at the bottom of the fragment is pressed, the given information is then updated to the datastore in the cloud. A fragment is an Android term that represents a portion of the user interface.
FragmentCheck 922: It is a fragment that determines if the given tilt and recline angles are in the ranges provided by the artificial neural network.
FragmentResult 923: It is a fragment that displays a list of ranges provided by the artificial neural network. These ranges are favorable tilt and recline combinations that can help reduce the risk of pressure ulcers.
FragmentOptimal 924: It is a fragment that displays the optimal angles of wheelchair tilt and recline provided by the artificial neural network.
FragmentFrequency 925: It is a fragment used to check the duration and frequency that the user should perform wheelchair tilt and recline functions. For example, the user should perform wheelchair tilt and recline functions every 15 minutes (i.e., frequency) and each time the user should maintain that setting for 3 minutes (i.e., duration).
FragmentAngleAdjustment 926: It is a fragment used to display the current angle of the wheelchair (tilt or recline). It reads the accelerometer sensor in the smartphone and calculates the current angle of the phone orientation for the user. A desired angle can be set by using the device's menu button. The background of this fragment will turn greener the closer the current angle is to the desired angle.
FragmentList 927: is a fragment that provides a list of functions that is offered by the smartphone app. It redirects a user to the appropriate functions based on the user's choice.
Datastore 93: this class is used by the mobile endpoints to interact with the Google App Engine datastore to manipulate data.
UserEndpoint 94: this Endpoint class manipulates ApplicationUser entities in the datastore by calling the Datastore class methods. Endpoint classes are located in the GAE source code and are annotated to be generated into an API to be used with Android.
ResultEndpoint 95: this endpoint creates a BloodFlowResult object to store results from the runBloodFlowCore method. Endpoint classes are located in the GAE source code and are annotated to be generated into an API to be used with Android.
BloodFlowCore 96: contains methods for interacting with the WEKA API, which is an open source data mining platform and returning the BloodFlowResult object. This is where the artificial neural network is built and angles are returned.
a is a non-limiting diagram showing a screen shot of a smartphone implementation of the present invention 10 providing a user interface 101 to access system functions. Both the local mobile version and the mobile-to-cloud version may have the same interface as shown in
b a non-limiting diagram showing a screen shot of a web-based implementation of the present invention 10 providing a user interface 102 to access system functions. System responses are anticipated and provided in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals may also be provided by the present invention 10.
a is a non-limiting diagram showing a screen shot of a smartphone implementation of the present invention 10 providing a user interface 110 to enter demographic attributes. System responses are anticipated and provided in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, and HP tablets, running operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Any such device having the minimum function set as described herein is anticipated.
b is a non-limiting diagram showing a screen shot of a web-based implementation of the present invention 10 providing a user interface 112 to enter demographic attributes. System responses are anticipated and provided in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10.
a is a non-limiting diagram showing a screen shot of a smartphone implementation of the present invention 10 providing a user interface 120 to display favorable tilt and recline angles. System responses are anticipated and provided in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, and HP tablets, running operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Implementation on any such device having the minimum function set as described herein is anticipated.
b is a non-limiting diagram showing a screen shot of a web-based implementation of the present invention 10 providing a user interface 122 to display favorable tilt and recline angles. System responses are anticipated in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10.
c is a non-limiting diagram showing a screen shot of a smartphone implementation of the present invention 10 providing a user interface 124 to display the best tilt and recline angle for the user. System responses are anticipated and provided in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, and HP tablets, running operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Implementation on any such device having the minimum function set as described herein is anticipated.
d is a non-limiting diagram showing a screen shot of a web-based implementation of the present invention 10 providing a user interface 126 to display the best tilt and recline angle for the user. System responses are anticipated in the present invention 10 to include at least user touch and voice commands. Audio recitation and response for visually impaired individuals is anticipated and provided by the present invention 10.
The present invention 10 can benefit all wheelchair users, who use a wheelchair with either a tilt or both tilt and recline functions. Both power and manual wheelchair users can benefit from this and other functions of the present invention 10. Healthcare providers and researchers will benefit from the present invention 10, as well. If they use the tilt and recline guidance provided by the present invention 10, the guidance will be automatically provided as inputs to the measurement and notification process 130 implemented in source code and operable on a mobile device. If the health providers and researchers do not use the personalized guidance, the present invention 10 will allow them to input alternative tilt and recline (TR) guidelines (see
As shown in
In step 2, the goniometer asks the wheelchair user to adjust the wheelchair to the upright position (i.e., no tilt or recline). As shown in
In step 3, the wheelchair user adjusts the wheelchair to the upright position following the voice guidance.
In step 4, the wheelchair user touches the screen of the smartphone after the wheelchair has been adjusted to the upright position.
In step 5, the goniometer asks the user to sit still so that the goniometer can record the initial position of the smartphone. This step is needed to ensure the precision of angle calculation.
Voice alert is used to guide the user. For example, the voice alert may recite the non-limiting script “Please do not move your phone for five seconds.” As shown in
In step 6, the goniometer may be configured to ask the user to adjust the tilt angle by using a voice alert. For example, the voice alert may recite the non-limiting script “You may now adjust your position. Please adjust your tilt to 15 degrees.”
In step 7, the wheelchair user starts to adjust the tilt angle as instructed by the voice alert. In the meantime, the goniometer will measure and display the current tilt angle on the screen of the smartphone as shown in
In step 8, if the target tilt angle has been reached, the goniometer may be configured to ask the wheelchair user to stop with the voice alert. For example, the voice alert may recite the non-limiting script “Please stop!”
In step 9, the goniometer may be configured to ask the wheelchair user to adjust the recline angle by using the voice alert. For example, the voice alert may recite the non-limiting script “Please adjust your Recline to 110 degrees.”
In step 10, the wheelchair user starts to adjust the recline angle. In the meantime, the goniometer will measure and display the current recline angle on the screen of the smartphone as shown in
In step 11, if the target recline angle has been reached, the goniometer of the present invention may be configured to use an aural instruction where the user may be asked with the voice alert to stop. For example the voice alert may recite the non-limiting script “Please stop! You are now in your target position.” In the meantime, the goniometer will also show the final angle and the stop message on the screen of the smartphone as shown in
αx, αy, αz
, which represents accelerations in three axes measured by the accelerometer. When the tilt or recline stabilizes to a new angle, accelerations in three axes will change due to the decomposition of the gravity along the new angle of the phone. Then, the present invention utilizes the dot product property to calculate angle changes between two vectors (positions):
ν1·ν2=|ν1|×|ν2|×cos θ (1)
Or equivalently,
θ=arccos(ν1·ν2/|ν1|×|ν2|) (2)
Hence, no matter how the smartphone is positioned, the TR angle θ between two vectors can be measured. In addition, the mobile subsystem 191 employs the novel text-to-speech technique, which enables the system to use voice alerts to guide wheelchair users for proper TR usage.
The present invention 10 provides a cloud computing-based subsystem 192 that can provide personalized guidance on wheelchair tilt and recline usage using the artificial neural network, and process, store, and analyze wheelchair 193 TR usage data. This subsystem employs the cloud computing paradigm, which can provide virtually unlimited resources for computation and data storage. Based on the longitudinal TR usage data, the present invention 10 may be used to provide operational applications for mobile devices to evaluate whether wheelchair users adjust enough TR angles to relieve seating pressure and whether they frequently reposition themselves by performing TR functions. The present invention 10 may be used to provide a novel machine-learning approach to analyze historical data of an individual wheelchair user, and assess his or her pressure ulcer (PU) risks correspondingly.
The present invention 10 may use the Google App Engine (GAE) as the cloud computing platform. GAE is managed by Google and provides a platform for developing and hosting web applications. Note that other techniques may be used to replace GAE. Essentially, there are currently three options: (1) continue to use commercial cloud computing platforms, such as Google App Engine, Microsoft Azure, Amazon EC2, etc.; (2) set up a dedicated private cloud computing platform; or (3) use a traditional web server as the data management and computation platform. Other options may emerge in the future and are anticipated as possible web development and hosting solutions to support implementation of various features of the present invention.
The combination of mobile and cloud computing can yield a balanced and integrated system, in which the mobile subsystem 191 will collect user's information, display personalized guidance on TR usage, control the sensor, measure wheelchair TR angles, and transmit TR usage data to the cloud, while the cloud subsystem 192 will handle the subsequent data management and analysis. Therefore, the present invention 10 provides a practical way to improve wheelchair 193 TR usage and capture longitudinal TR usage data among wheelchair users
The mobile application of the present invention 10 may be implemented for any mobile operating system, including the mainstream mobile operating systems, such as Google Android, Apple iOS, and Microsoft Windows. To use the mobile application provided by the present invention 10, the user needs to download it from an accessible public source where it may be made available, such as Google Play, Apple Store, or Windows App Store depending on the mobile operating systems they use.
Preferred embodiments of the present invention may comprise generating personalized adjustment parameters directed to positioning and control of seating configurations in both commercial and private automotive vehicles, including trucks and passenger cars. Outcome objectives may reflect both safety and comfort. A smartphone implementation providing a user interface to display at least current position and shape parameters and send related control parameters to powered, adjustable seats is anticipated. System responses are anticipated to at least user touch and voice commands. Audio recitation and response is anticipated. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, HP tablets, Google glass, iWatch, etc, running on operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Any such mobile device having the minimum function set as described herein is anticipated. Implementation using on-board devices installed as vehicle equipment is also anticipated.
Preferred embodiments of the present invention may comprise generating personalized adjustment parameters directed to positioning and control of seating configurations in aircraft including both crew and passenger seating. Outcome objectives may reflect both safety and comfort. A smartphone implementation providing a user interface to display at least current position and shape parameters and send related control parameters to powered, adjustable seats is anticipated. System responses are anticipated to at least user touch and voice commands. Audio recitation and response is anticipated. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, HP tablets, Google glass, iWatch, etc, running on operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Any such mobile device having the minimum function set as described herein is anticipated. Implementation using on-board devices installed as vehicle equipment is also anticipated.
Preferred embodiments of the present invention may comprise generating personalized adjustment parameters directed to positioning and control of seating configurations in furniture, including tilt and recline angle, seat and back shape, firmness and support. Outcome objectives may reflect both safety and comfort. A smartphone implementation providing a user interface to display at least current position and shape parameters and send related control parameters to powered, adjustable seats is anticipated. System responses are anticipated to at least user touch and voice commands. Audio recitation and response is anticipated. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, HP tablets, Google glass, iWatch, etc., running on operating systems such as Android, iOS, and Windows, where such devices include an accelerometer. Any such mobile device having the minimum function set as described herein is anticipated. Implementation using on-board devices installed as furniture components is also anticipated.
Preferred embodiments of the present invention may comprise generating personalized adjustment parameters directed to positioning and control of support and comfort configurations in both commercial and private sleep platforms for healthcare, hospitality and in-home applications. A smartphone implementation providing a user interface to display at least current position and shape parameters, and send related control parameters to powered, adjustable seats is anticipated. System responses are anticipated to at least user touch and voice commands. Audio recitation and response is anticipated. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, HP tablets, Google glass, iWatch, etc., running on operating systems such as Android, iOS, and Windows. Any such mobile device having the minimum function set as described herein is anticipated. Implementation using on-board devices installed as sleep-platform equipment components is also anticipated.
Preferred embodiments of the present invention may comprise using the goniometer functions implemented in a mobile device for generating and recording personalized parameters directed to measuring and scoring joint range of motion and flexibility by clinicians including at least physical therapists, orthopedists, physical medicine clinicians and sports medicine practitioners. Goniometric measurements provided using the mobile version of the present invention may be used as outcome measures (e.g., after a course of treatment), as an exam finding to aid in the diagnosis of a condition, and to determine level of fitness for a specific purpose. System responses are anticipated to at least user touch and voice commands. Audio recitation and response is anticipated. User touch, voice activation and audio recitation functions are generally programmable and operable on industry standard smart devices, such as various device models of iPhone, iPad, Samsung Galaxy, HP tablets, Google glass, iWatch, etc., running on operating systems such as Android, iOS, and Windows. Any such mobile device having the minimum function set as described herein is anticipated.
Those skilled in the art will appreciate that in some embodiments of the invention, the functional modules of the Web implementation, as well as the personal and the integrated communication devices, may be implemented as pre-programmed hardware or firmware elements (e.g., application specific integrated circuits (ASICs), electrically erasable programmable read-only memories (EEPROMs), etc.), or other related components. Mobile communication devices that can use the present invention may include but are not limited to any of the “smart” phones or tablet computers equipped with digital displays, wireless communication connection capabilities such as iPhones and iPads available from Apple, Inc., as well as communication devices configured with the Android operating system available from Google, Inc and with the Windows operating system available from Microsoft. In addition, it is anticipated that the new communication devices and operating systems will become available as more capable replacements of the forgoing listed communication devices, and these may use the present invention as well.
In other embodiments, the functional modules of the mobile-to-cloud implementation may be implemented by an arithmetic and logic unit (ALU) having access to a code memory which holds program instructions for the operation of the ALU. The program instructions could be stored on a medium which is fixed, tangible and readable directly by the processor, (e.g., removable diskette, CD-ROM, ROM, or fixed disk), or the program instructions could be stored remotely but transmittable to the processor via a modem or other interface device (e.g., a communication adapter) connected to a network over a transmission medium. The transmission medium may be either a tangible medium (e.g., optical or analog communications lines) or a medium implemented using wireless techniques (e.g., microwave, infrared or other transmission schemes).
The program instructions stored in the code memory can be compiled from a high level program written in a number of programming languages for use with many computer architectures or operating systems. For example, the program may be written in assembly language suitable for use with a pixel shader, while other versions may be written in a procedural programming language (e.g., “C”) or an object oriented programming language (e.g., “C++” or “JAVA”).
In other embodiments, cloud computing may be implemented on a web hosted machine or a virtual machine. A web host can have anywhere from one to several thousand computers (machines) that run web hosting software, such as Apache, OS X Server, or Windows Server. A virtual machine (VM) is an environment, usually a program or operating system, which does not physically exist but is created within another environment (e.g., Java runtime). In this context, a VM is called a “guest” while the environment it runs within is called a “host.” Virtual machines are often created to execute an instruction set different than that of the host environment. One host environment can often run multiple VMs at once.
While specific embodiments of the present invention have been described and illustrated, it will be apparent to those skilled in the art that numerous modifications and variations can be made without departing from the scope of the invention as defined in the appended claims. It is understood that the words that have been used are words of description and illustration, rather than words of limitation. Although the invention has been described with reference to particular means, materials and embodiments, the invention is not intended to be limited to the particulars disclosed; rather, the invention extends to all functionally equivalent structures, methods and uses, such as are within the scope of the appended claims.
This application claims the benefit of U.S. Provisional Patent Application No. 61/891,600 filed on Oct. 16, 2013 in the name of Jicheng Fu, which is expressly incorporated herein by reference in its entirety.
This invention was made with Government support of OK-INBRE (Oklahoma IDeA Network of Biomedical Research Excellence). The OK-INBRE is a grant from the National Institute of General Medical Sciences of the National Institutes of Health through Grant Number 8P20GM103447. The Government has certain rights in this invention.
| Number | Date | Country | |
|---|---|---|---|
| 61891600 | Oct 2013 | US |
