Claims
- 1. A prostaglandin analog of the formula ##STR2## wherein Y is cis--CH.dbd.CH-- or trans--CH.dbd.CH--; wherein m is one to 5, inclusive; wherein M.sub.1 is ##STR3## or ##STR4## wherein R.sub.5 and R.sub.6 are hydrogen or methyl, with the proviso that one of R.sub.5 and R.sub.6 is methyl only when the other is hydrogen;
- Wherein L.sub.1 is ##STR5## or a mixture of ##STR6## and ##STR7## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, being the same or different, with the proviso that one of R.sub.3 and R.sub.4 is fluoro only when the other is hydrogen or fluoro;
- Wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, two, or three chloro or alkyl of one to 3 carbon atoms, inclusive, or a pharmacologically acceptable cation; and
- Wherein Z.sub.8 is
- (1) --CH.sub.2 --O--CH.sub.2 --(CH.sub.2).sub.g --CH.sub.2 --,
- (2) --(ch.sub.2).sub.2 --o--(ch.sub.2).sub.g --CH.sub.2 --, or
- (3) --(CH.sub.2).sub.3 --O--(CH.sub.2).sub.g --,
- Wherein g is one, 2, or 3.
- 2. A compound according to claim 1, wherein M.sub.1 is ##STR8##
- 3. A compound according to claim 1, wherein M.sub.1 is ##STR9##
- 4. A compound according to claim 3, wherein Y is cis--CH.dbd.CH--.
- 5. A compound according to claim 4, wherein m is 3.
- 6. A compound according to claim 5, wherein g is 3.
- 7. 2a,2b-Dihomo-5-oxa-9.beta.-15-epi-cis-13-PGD.sub.1, a compound according to claim 6.
- 8. A compound according to claim 5, wherein g is one.
- 9. 5-Oxa-9.beta.-15-epi-cis-13-PGD.sub.1, a compound according to claim 8.
- 10. 3-Oxa-9.beta.-15-epi-cis-13-PGD.sub.1, a compound according to claim 8.
- 11. A compound according to claim 3, wherein Y is trans--CH.dbd.CH--.
- 12. A compound according to claim 11, wherein m is 3.
- 13. A compound according to claim 12, wherein Z.sub.8 is
- --CH.sub.2 --O--CH.sub.2 --(CH.sub.2).sub.g --CH.sub.2 --.
- 14. A compound according to claim 13, wherein g is 3.
- 15. A compound according to claim 13, wherein g is one.
- 16. A compound according to claim 15, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 17. A compound according to claim 16, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 18. 5-Oxa-9.beta.-PGD.sub.1, a compound according to claim 17.
- 19. A compound according to claim 16, wherein R.sub.3 and R.sub.4 are both fluoro.
- 20. 16,16-Difluoro-5-oxa-9.beta.-PGD.sub.1, a compound according to claim 19.
- 21. A compound according to claim 12, wherein Z.sub.8 is
- --(CH.sub.2).sub.3 --O--(CH.sub.2).sub.g --.
- 22. A compound according to claim 21, wherein g is 3.
- 23. A compound according to claim 22, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 24. A compound according to claim 23, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 25. 2a,2b-Dihomo-3-oxa-9.beta.-PGD.sub.1, a compound according to claim 24.
- 26. A compound according to claim 23, wherein R.sub.3 and R.sub.4 are both fluoro.
- 27. 2a,2b-Dihomo-16,16-difluoro-3-oxa-9.beta.-PGD.sub.1, a compound according to claim 26.
- 28. A compound according to claim 21, wherein g is one.
- 29. A compound according to claim 28, wherein R.sub.5 and R.sub.6 are both hydrogen.
- 30. A compound according to claim 29, wherein R.sub.3 and R.sub.4 are both hydrogen.
- 31. 3-oxa-9.beta.-PGD.sub.1, a compound according to claim 30.
- 32. A compound according to claim 29, wherein R.sub.3 and R.sub.4 are both fluoro.
- 33. 16,16-Difluoro-5-oxa-9.beta.-PGD.sub.1, a compound according to claim 32.
Parent Case Info
The present application is a divisional application of Ser. No. 614,242, filed Sept. 17, 1975, now issued as U.S. Pat. No. 4,016,184, on Apr. 5, 1977.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3862979 |
Gandolfi et al. |
Jan 1975 |
|
3933904 |
Strike et al. |
Jan 1976 |
|
3954844 |
Colton et al. |
May 1976 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
614242 |
Sep 1975 |
|