Interactions Between Angiotensin II and Substance P in Dorsal Medulla Autonomic Pathways

Information

• NSF Award
• 9109673

Owner

• CLEVELAND CLINIC FOUNDATION, THE, A OHIO CORP

• Award Id

  9109673

• Award Effective Date

  8/1/1991 - 33 years ago

• Award Expiration Date

  1/31/1995 - 29 years ago

• Award Amount

  $ 205,758.00

• Award Instrument

  Continuing grant

Cardiovascular and respiratory functions are regulated by nerve cells in an area of the brainstem called the nucleus of the solitary tract. Dr. Barnes' research is aimed at recording activity in this area of the brainstem in order to determine how it functions. Hypotension and bradycardia can be produced by application of two neuropeptides, substance P and angiotensin II, into this area. The interactions of these two substances and their effects on autonomic nervous system functioning will be studied. This research will contribute to understanding the role of neuropeptides in the control cardiovascular and respiratory functions.

• Program Officer

  Carol Colby

• Min Amd Letter Date

  8/6/1991 - 33 years ago

• Max Amd Letter Date

  5/7/1993 - 31 years ago

• ARRA Amount

• Name

  Cleveland Clinic Foundation

• City

  Cleveland

• State

  OH

• Country

  United States

• Address

  9500 Euclid Avenue

• Postal Code

  441950001

• Phone Number

  2164456440

• First Name

  Karen

• Last Name

  Barnes

• Start Date

  8/1/1991 12:00:00 AM

• Name

  Other Applications NEC

• Code

  99

• Name

  Life Science Biological

• Code

  61

• Text

  BEHAVIORAL NEUROSCIENCE

• Code

  1191