Patent Application
20240358353
Contrast-enhanced imaging, such as contrast enhanced ultrasound (CEUS) imaging requires multiple steps to be executed in a specific sequence, which is often referred to as a protocol. Known CEUS imaging protocols require timely action by an operator and are done manually. For example, once entering a contrast mode, the operator is required to initiate a contrast injection, and begin timing the procedure upon arrival of first bubbles in the contrast medium. Shortly before or after the incidence of the first bubbles, the operator must begin acquiring images or imaging loops over time, or both.
After initial acquisition of images and/or loops, the operator typically terminates image/loop acquisition after a designated period of time (e.g., 30-60 s). Often, this image/loop acquisition initiation and termination sequence may be repeated at predetermined time intervals to capture images/loops at desired times of the contrast agent circulation. For example, the acquisition of images/loops may be repeated to capture a 10 s imaging loop every 30 s, or to capture 10 images 10 s apart.
During an imaging sequence of a subject, it is sometimes desired to freeze the ultrasound transducer so that ultrasonic waves are not transmitted for a certain period of time to reduce the incidence of contrast bubble destruction. This is done a number of times during an imaging procedure of the subject between image/loop capture sequences.
Moreover, there are times when another injection of contrast agent is useful during an imaging procedure. Often, the repeated injection is initiated after a predetermined duration of time.
Known imaging protocols, such as those described above, are carried out manually, with the operator of the imaging system beginning and terminating various steps by manual timing. These imaging protocols often entail a comparatively difficult workflow, which requires precision in both imaging and contrast injection timing. As will be appreciated, known methods that require manual execution of timed sequences of image acquisition and manipulation required in some imaging modes, such as contrast-enhanced ultrasound imaging, is challenging and fraught with errors in image acquisition initiation and termination, resulting in loss of data and/or the need for repeated injections.
What are needed, therefore, are a device, method and system that overcomes at least the drawbacks of known methods and systems described above.
According to an aspect of the present disclosure, a display for a contrast-enhanced examination ultrasound (CEUS) exam is disclosed. The display comprises: a menu comprising an editable protocol adapted to allow a user to select time-based actions and events of an upcoming CEUS exam on the display: a first time-bar display adapted to allow the user to alter time-based actions during the CEUS exam, and to provide visual indications of upcoming actions on the display; and a second time-bar display adapted to allow the user to display images and loops acquired during the CEUS exam on the display.
According to another aspect of the present disclosure, a method of controlling an imaging procedure is disclosed. The method comprises: providing a menu comprising editable protocol adapted to allow a user to select time-based actions and events of an upcoming contrast enhanced ultrasound (CEUS) exam on a display: providing a first time-bar display adapted to alter time-based actions during the CEUS exam, and provide visual indications of upcoming actions on the display; and providing a second time-bar display configured to display images and loops acquired during the CEUS exam on the display.
According to another aspect of the present disclosure, a tangible, non-transitory computer-readable medium that stores instructions is disclosed. The instructions, when executed by a processor, cause the processor to: provide a menu comprising editable protocol adapted to allow a user to select time-based actions and events of an upcoming contrast enhanced ultrasound (CEUS) exam on a display: provide a first time-bar display adapted to alter time-based actions during the CEUS exam, and provide visual indications of upcoming actions on the display; and provide a second time-bar display configured to display images and loops acquired during the CEUS exam on the display.
The representative embodiments are best understood from the following detailed description when read with the accompanying drawing figures. It is emphasized that the various features are not necessarily drawn to scale. In fact, the dimensions may be arbitrarily increased or decreased for clarity of discussion. Wherever applicable and practical, like reference numerals refer to like elements.
In the following detailed description, for the purposes of explanation and not limitation, representative embodiments disclosing specific details are set forth in order to provide a thorough understanding of an embodiment according to the present teachings. Descriptions of known systems, devices, materials, methods of operation and methods of manufacture may be omitted so as to avoid obscuring the description of the representative embodiments. Nonetheless, systems, devices, materials and methods that are within the purview of one of ordinary skill in the art are within the scope of the present teachings and may be used in accordance with the representative embodiments. It is to be understood that the terminology used herein is for purposes of describing particular embodiments only and is not intended to be limiting. The defined terms are in addition to the technical and scientific meanings of the defined terms as commonly understood and accepted in the technical field of the present teachings.
It will be understood that, although the terms first, second, third, etc. may be used herein to describe various elements or components, these elements or components should not be limited by these terms. These terms are only used to distinguish one element or component from another element or component. Thus, a first element or component discussed below could be termed a second element or component without departing from the teachings of the inventive concept.
The terminology used herein is for purposes of describing particular embodiments only and is not intended to be limiting. As used in the specification and appended claims, the singular forms of terms “a.” “an” and “the” are intended to include both singular and plural forms, unless the context clearly dictates otherwise. Additionally, the terms “comprises.” “comprising.” and/or similar terms specify the presence of stated features, elements, and/or components, but do not preclude the presence or addition of one or more other features, elements, components, and/or groups thereof. As used herein, the term “and/or” includes any and all combinations of one or more of the associated listed items.
By the present teachings, implementation of an imaging protocol is facilitated using a menu on a display, a user interface and/or a GUI, real time reminders and alerts provided on a display, and image/loop review on the display. Notably, the real time reminders and alerts may also be audible. Among other benefits, better control of an imaging procedure, fewer errors during the imaging procedure, and facilitated review of images/loops acquired during the imaging procedure are realized.
Referring to
The computer system 115 receives image data from the imaging device 110, and stores and processes the imaging data according to representative embodiments described herein. The computer system 115 comprise a controller 120, a memory 130, a display 150 comprising a graphical user interface (GUI) 155, and a user interface 160. The display 150 may also include a loudspeaker (not shown) to provide audible feedback.
The controller 120 interfaces with the imaging device 110 through an imaging interface 111. The memory 130 stores instructions executable by the controller 120. When executed, and as described more fully below, the instructions cause the controller 120 to allow the user to schedule different steps of a protocol using the GUI 155 or the user interface 160, or both, and to selectively retrieve images or loops, or both taken at certain times during the exam (e.g., CEUS exam). In addition, the controller 120 may implement additional operations based on executing instructions, such as instructing or otherwise communicating with another element of the computer system 115, including the memory 140 and the display 150, to perform one or more of the above-noted processes.
The controller 120 is representative of one or more processing devices, and is configured to execute software instructions stored in memory 130 to perform functions as described in the various embodiments herein. The controller 120 may be implemented by field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), a general purpose computer, a central processing unit, a computer processor, a microprocessor, a graphics processing unit (GPU), a microcontroller, a state machine, programmable logic device, or combinations thereof, using any combination of hardware, software, firmware, hard-wired logic circuits, or combinations thereof. Additionally, any processing unit or processor herein may include multiple processors, parallel processors, or both. Multiple processors may be included in, or coupled to, a single device or multiple devices.
The term “processor” as used herein encompasses an electronic component able to execute a program or machine executable instruction. References to a computing device comprising “a processor” should be interpreted to include more than one processor or processing core, as in a multi-core processor. A processor may also refer to a collection of processors within a single computer system or distributed among multiple computer systems, such as in a cloud-based or other multi-site application. The term computing device should also be interpreted to include a collection or network of computing devices each including a processor or processors. Programs have software instructions performed by one or multiple processors that may be within the same computing device or which may be distributed across multiple computing devices.
The memory 130 may include a main memory and/or a static memory, where such memories may communicate with each other and the controller 120 via one or more buses. The memory 130 stores instructions used to implement some or all aspects of methods and processes described herein. The memory 130 may be implemented by any number, type and combination of random access memory (RAM) and read-only memory (ROM), for example, and may store various types of information, such as software algorithms, which serves as instructions, which when executed by a processor cause the processor to perform various steps and methods according to the present teachings. Furthermore, updates to the methods and processes described herein may also be provided to the computer system 115 and stored in memory 130.
The various types of ROM and RAM may include any number, type and combination of computer readable storage media, such as a disk drive, flash memory, an electrically programmable read-only memory (EPROM), an electrically erasable and programmable read only memory (EEPROM), registers, a hard disk, a removable disk, tape, compact disk read only memory (CD-ROM), digital versatile disk (DVD), floppy disk, Blu-ray disk, a universal serial bus (USB) drive, or any other form of storage medium known in the art. The memory 130 is a tangible storage medium for storing data and executable software instructions, and is non-transitory during the time software instructions are stored therein. As used herein, the term “non-transitory” is to be interpreted not as an eternal characteristic of a state, but as a characteristic of a state that will last for a period. The term “non-transitory” specifically disavows fleeting characteristics such as characteristics of a carrier wave or signal or other forms that exist only transitorily in any place at any time. The memory 130 may store software instructions and/or computer readable code that enable performance of various functions. The memory 130 may be secure and/or encrypted, or unsecure and/or unencrypted.
“Memory” is an example of computer-readable storage media, and should be interpreted as possibly being multiple memories or databases. The memory or database may for instance be multiple memories or databases local to the computer, and/or distributed amongst multiple computer systems or computing devices. A computer readable storage medium is defined to be any medium that constitutes patentable subject matter under 35 U.S.C. § 101 and excludes any medium that does not constitute patentable subject matter under 35 U.S.C. § 101. Examples of such media include non-transitory media such as computer memory devices that store information in a format that is readable by a computer or data processing system. More specific examples of non-transitory media include computer disks and non-volatile memories.
The user interface 160 may include a user and/or network interface for providing information and data output by the controller 120 and/or the memory 130 to the user and/or for receiving information and data input by the user. That is, the user interface 160 enables the user to enter data and to schedule, control or manipulate aspects of the processes described herein, and enables the controller 120 to indicate the effects of the user's control or manipulation. The user interface 160 may include one or more of ports, disk drives, wireless antennas, or other types of receiver circuitry. The user interface 160 may further connect one or more user interfaces, such as a mouse, a keyboard, a mouse, a trackball, a joystick, a microphone, a video camera, a touchpad, a touchscreen, voice or gesture recognition captured by a microphone or video camera, for example.
The display 150 may be a monitor such as a computer monitor, a television, a liquid crystal display (LCD), a light emitting diode (LED) display, a flat panel display, a solid-state display, or a cathode ray tube (CRT) display, or an electronic whiteboard, for example. The display 150 may also provide a graphical user interface (GUI) 155 for displaying and receiving information to and from the user.
As alluded to above, and as described in more detail below, in accordance with various representative embodiments, various aspects of imaging protocols may be selectively scheduled by the user to carry out certain desired functions during an imaging procedure. Moreover, in accordance with representative embodiments, reminders may be provided to the user during the execution of the imaging protocol. Furthermore, after the imaging scan is completed, in accordance with representative embodiments, review of acquired images/loops is facilitated by pairing of the images/loops to a particular time of the executed protocol. For purposes of illustration, and not limitation,
The protocol 200 is illustratively a CEUS protocol and includes common steps and actions used in CEUS imaging. Again, it is emphasized the application of the present teachings to CEUS imaging is merely illustrative, and the various aspects of the present teachings are contemplated for use in other imaging modalities. Furthermore, various aspects and details of the protocol 200 and the attendant method are common to those described above, and may not be repeated in order to avoid obscuring the discussion of the present representative embodiment.
As alluded to above, and as described more fully below, various steps in the sequence of the protocol are implemented using a menu (not shown in
The protocol 200 begins at 202 with a pre-contrast imaging step performed by the user/operator of the imaging system 100 on which the protocol 200 is carried out. Like all other steps in the protocol, the pre-contrast imaging step may be selected using a menu (not shown in
After completion of the pre-contrast imaging step at 202, the protocol 200 continues with entry of a contrast mode at 204 in which various settings are adjusted, or in which preset default conditions are selected. Entrance in the contrast mode at 204 is done during the scheduling sequence of the protocol 200, and may be selected using a menu (not shown in
The protocol 200 continues with injection of a contrast agent at 206 into the subject or patient. The injection of the contrast agent at 206 is scheduled during the scheduling sequence of the protocol 200. The injection of the contrast agent at 206 using the user interface 160 of the GUI 155 to select the injection of the contrast agent from a menu (not shown in
After completion of injection of the contrast agent at 206, the user may select to activate a contrast timer at 208 using the user interface 160, or the GUI 155 to select the time and duration of the timer from a menu (not shown in
After activation of the contrast timer at 208, imaging and loop acquisition be carried out after injection of the contrast agent to ensure first arrival of the contrast agent, and subsequently the early arterial phases. Notably, as described more fully below, the commencement and termination of this contrast timer at 208 may be displayed on the screen, or an alert to signal its termination may be provided by the display 150, or both. In this manner, the user or operator of the imaging system 100 is able to initiate an image acquisition loop at 210. Alternatively, prior to commencement of the protocol 200, the user may set a user timer using a menu (not shown in
The duration of the image acquisition loop beginning at 210 is beneficially selectable by the present teachings, as are the acquisition frame rates. The duration of the image acquisition loop beginning at 210 may be selected by the user/operator using the user interface 160 and/or the GUI 155 via a selection on the menu (not shown in
Next, after the duration of the loop acquisition at 210, the loop acquisition is terminated at 212. The duration of the loop acquisition at 210 may be displayed on the screen, or an alert to signal the termination of the duration of the loop acquisition at 210, or both, may be provided by the display 150. In this manner, the user or operator of the imaging system 100 is able to terminate an image acquisition loop at 212. Alternatively, the user may set the timer using a menu (not shown in
The length of the arterial phase may vary significantly based on organ, patient health, and other factors. The length of time from peak contrast signal to late-phase can also vary significantly based on organ, patient, and lesion. For example, in some patients the contrast agent may clear quickly and cease to provide any useful signal past 1 or 2 minutes. In these cases, the protocol 200 may be usefully configured to enable the user/operator to bypass multiple upcoming events to advance to the review/quantification/reporting stages. Similarly, the ideal time to make changes to acoustic properties (e.g. acquisition frame rate, transmit line density, etc.) in order to preserve contrast agent may not be consistent from patient to patient, but rather may depend on where in the wash-in/wash-out sequence the user is currently. Finally, and as discussed more fully below, annotation and marking of loops/frames of interest have benefits to quantification and reporting that happen post-exam. These annotations and markings may be carried out via the user interface 160 or the GUI 155, or both.
After termination of the loop acquisition at 212, the imaging system 100 may enter a freeze mode at 214. The freezing of the imaging system halts transmission of ultrasound waves to the body. This may be done for a number of reasons, including, for example, to preserve bubbles in the contrast agent, which may be diminished or eliminated by the ultrasonic waves. The freezing at 214 is generally effected when the images that can be gathered are not of interest, or are not useful to the particular scan being undertaken. In certain imaging procedures, the contrast agent level reaches a peak level and subsequently the level decays over time or reaches a steady state. During these times, it may be not be useful to gather images. Moreover, there are a number of factors that drive the duration of the freeze, including, but not limited to the behavior of a certain type of lesion with respect to the contrast agent. Accordingly, the initiation and duration of the freeze at 214 may vary depending on various factors. As such, the selection of the commencement and termination of the freeze at 214 is beneficially controllable. Notably, the freezing and unfreezing may be done based on image observation by the operator, or may be fixed by the protocol. Specifically, in some organizational situations, the radiologist would set a strict protocol that all technologists must follow. This would result in a fixed duration so that all presented similarly to the radiologist. In other circumstances, the radiologist/doctor may carry out the scan, and may alter timing based on observations. In vet other circumstances, the data collection may be part of clinical research, where adherence to strict protocols requiring fixed duration is beneficial.
Commencement and termination (i.e., duration) of the freezing of the imaging system 100 at 214 may be displayed on the display, or an alert to signal its termination may be provided by the display 150, or both. In this manner, the user or operator of the imaging system 100 is able to initiate and terminate freezing of the imaging system 100 at 214 for a desired period of time by interaction with the display 150 in real time using a menu (not shown in
After termination of the freeze at 214, another loop acquisition is initiated at 216. In this manner. In either case, the user or operator of the imaging system 100 is able to initiate another image acquisition loop at 216. Again, the time to commence the next loop acquisition at 216 may be shown on the display 150, or an alert to signal its termination may be provided by the display 150, or both. Alternatively, the user may set the timer using a menu (not shown in
Next, after the duration of the loop acquisition at 216, the loop acquisition is terminated at 218. The duration of the loop acquisition (illustratively 30 s) may be shown on the display, or an alert to signal the termination of the duration may be provided by the display 150, or both. In this manner, the user or operator of the imaging system 100 is able to terminate an image acquisition loop at 218. Alternatively, the user may set the timer using the user interface 160 or GUI 155 prior to commencement of the protocol 200 to terminate the acquisition of a loop that began at 216, and is terminated at 218. As such, the timer of the image acquisition at 218 may be set and activated during the configuring of the protocol 200 by the user/operator.
After termination of the acquisition of the loop that began at 216, the protocol 200 continues to the next stage of the imaging sequence. Notably, at 220 the user/operator may advance to the review of the acquired images/loops, select a wash-in loop, or annotate the images gathered during the scans. As described more fully below, the user/operator may perform thesc functions on the display 150 using the user interface 160 or the GUI 155, or both.
After completing the review and other actions at 220, the protocol proceeds to initiate quantification at 222. The quantification at 222 generally comprises the launching of internal or external applications that analyze the key CEUS images/loops for quantification parameters of interest. For example, it may be useful to study how the time versus intensity properties differ between pixels in healthy tissue and pixels in a lesion of interest. These analyses are used as additional inputs to diagnosis or reporting. Illustratively, the user can initiates quantification by manipulating the GUI while in review or freeze and selecting from a GUI button that launches the quantification toolset with the current loop as input.
Finally, upon completion of the quantification at 222, the protocol 200 proceeds to 224 to report the various findings according to a desired reporting protocol such as ultrasound liver Imaging reporting and data system (LIRADS): thyroid imaging, reporting and data system (TIRADS): or breast imaging and reporting data system (BIRADS) to mention only a few. The reporting protocol selected can be set prior to the beginning of the protocol 200 using a menu (not shown in
Alternatively, the user/operator may decide to introduce a second injection of contrast agent as shown. This may be done for one of a number of reasons, such as when the operator believes the first set of images/loops are not suitable for analysis. Alternatively, if the user/operator has found additional lesions in the course of a first exam, additional imaging may be carried out to further investigate. Repeating the sequence beginning with the at 206 can be done in real time using a menu (not shown in
The menu 302 comprises a first sub-menu 304 and a second sub-menu 306. The first sub-menu 304 provides a plurality of options that are generally contrast-specific in nature. In generating the protocol, the user/operator selects options on a first drop-down menu 305. These options include those described above in connection with
A second drop-down menu 307 comprises options for timing of actions including but not limited start time, end time, and duration for the various actions described in connection with
As alluded to above, the second sub-menu 306 and the second drop-down menu 307 are created by execution of instructions stored in memory 130 by the controller 120, and are modified using the user interface 160, or the GUI 155, or both.
Notably, the selection of an option from the first drop-down menu 305 causes the second drop down menu to provide various options for the selected action of the first drop-down menu 305. For example, the first time-bar display 300 shows the selection of “Loop Acquisition-Wash In” in the first drop-down menu 305. The selection of “Loop Acquisition-Wash In” on the first drop-down menu 305 causes the display of various options on the second drop-down menu 307 that are useful to the selected action of the protocol, which then provides options “Loop Acquisition-Wash In.” These include the ability to select the imaging mode (3D or 2D), the type of acquisition (loop, image, or both), the duration of the selected action (in this case Loop Acquisition-Wash In), and the desired portion of the display 150 shown during this portion of the protocol. Other options available to the user in the second drop-down menu 307 include many described above including start and end times, and the ability to select alerts and prompts presented on the display 150 during execution of the particular protocol selected. Illustratively, and as described in connection with
The second time-bar display 400 shows a first screen 402 and a second screen 404 with CEUS images 403 and 407, respectively. The first and second screens 402, 404 further comprise a bar 405 that scrolls based on event or action triggers and timing specifications for actions to be taken by the user operator. As shown in the first screen 402, a first alert 406 is provided to prompt the user/operator to be ready for an upcoming action in a specified time (e.g., 3 s) of the generated protocol. As noted above, in addition to the display of the first alert 406, an audio alert, or a haptic alert, or both may accompany the first alert 406. After the passing of the first alert 406, a first prompt 408 shows the appropriate time for the user/operator to engage the timer for the action being taken. In the present example, the first alert 406 and the first prompt 408 are used to ensure an image/loop acquisition is carried out beginning at a particular time during the imaging scan and according to the generated protocol.
As shown in the second screen 404, a second alert 409 is displayed to prompt the user/operator to terminate the image/loop acquisition at the time specified by the protocol (e.g., using first time-bar display 300 on the display 150), and after the selected duration specified by the protocol. As noted above, in addition to the display of the first alert 406, an audio alert, or a haptic alert, or both may accompany the second alert 409. The second alert 409 shows the appropriate time for the user/operator to terminate the scan according to the protocol. Notably another alert (not shown) may be provided to warn the user/operator that the termination time of the current acquisition is upcoming. In the present example, the second alert 409 is used to ensure an image/loop acquisition, and is terminated at a particular time during the imaging scan and according to the generated protocol.
The menu 502 comprises a first sub-menu 504 and a second sub-menu 506. As described more fully below, the first and second sub-menus 504, 506 allow a user/operator to review images gathered and transitions between actions taken during the various steps in the protocol generated as described in connection with
The first sub-menu 504 provides a list of the actions taken during the protocol the user/operator selected while generating the protocol. Options provided on a first drop-down menu 505 feature the actions. These options include those described above in connection with
The second drop-down menu 507 comprises a list the various parameters of the selected portion of the CEUS imaging scan of the generated protocol. The second drop-down menu 507 includes the various timing of actions including but not limited start time, end time, and duration for the various actions selected using second drop-down menu 307 described in connection with
View 500 shows the loops acquired in sequence during the entire protocol. Images 512 represent thumbnails from the loops taken in the previous steps through the current step. In an example, the review bar on the right hand side of view 500 could be set to display the images in a time sequence with appropriate labels (e.g. separate containing boxes for each phase, or in a line with timing denoted next to the thumbnails and annotations regarding which step in the protocol they were taken from). In a live imaging setting, the right hand elements in images 512 would represent the past events in the current and/or previous sequences and selected images 508, 510 would represent the live image at the current instance of scanning. In this context, the left hand side of view 500 represents past/present/upcoming events, and check marks indicate what has already been completed.
The user/operator can select images 508, 510 from the images 512 for further review after completion of the protocol. Notably, the images 512 include the time of their acquisition during the protocol, and therefore, allow the user/operator to select certain images for further review. Just by way of illustration, buttons can be used to add indications that these buttons can be used to move through the protocol. For example, in a live imaging mode, button 516 to the left of a trackball circle 514 could be used to repeat the previous protocol element, middle button 518 at the top of the trackball circle 514 could be used to advance to the next protocol element, and button 520 to the right of the trackball circle 514 could be used to end the exam and advance to review. If this display were used in review, the same button assignments could be used to move between loops/images taken at previous and next protocol elements.
At 602, the method begins by providing a user interface comprising editable protocol adapted to allow a user to select time-based actions and events of an upcoming contrast enhanced ultrasound (CEUS) exam on a display.
At 604 the method comprises providing a first time-bar display adapted to alter time-based actions during the CEUS exam, and provide visual indications of upcoming actions on the display.
At 606, the method comprises providing a second time-bar display configured to display images and loops acquired during the CEUS exam on the display.
As will be appreciated by one of ordinary skill in the art having the benefit of the present disclosure, the systems and methods of the present teachings provide an improvement in the implementation of imaging protocols, such as used in CEUS imaging. For example, compared to known methods and systems, various aspects of a protocol including the beginning, duration and termination of a step in the protocol can be facilitated during the generation of the protocol, or during implementation of the protocol, or both. Moreover, errors that can result from human interaction with an imaging system can be reduced thereby reducing the need to repeat procedures, and reducing the time required to complete an imaging procedure. Notably, these benefits are illustrative, and other advancements in the field of medical imaging will become apparent to one of ordinary skill in the art having the benefit of the present disclosure.
Although methods, systems and components for implementing imaging protocols have been described with reference to several exemplary embodiments, it is understood that the words that have been used are words of description and illustration, rather than words of limitation. Changes may be made within the purview of the appended claims, as presently stated and as amended, without departing from the scope and spirit of the protocol implementation of the present teachings.
The preceding description of the disclosed embodiments is provided to enable any person skilled in the art to practice the concepts described in the present disclosure. As such, the above disclosed subject matter is to be considered illustrative, and not restrictive, and the appended claims are intended to cover all such modifications, enhancements, and other embodiments which fall within the true spirit and scope of the present disclosure. Thus, to the maximum extent allowed by law, the scope of the present disclosure is to be determined by the broadest permissible interpretation of the following claims and their equivalents and shall not be restricted or limited by the foregoing detailed description.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2022/073865 | 8/28/2022 | WO |
| Number | Date | Country | |
|---|---|---|---|
| 63238247 | Aug 2021 | US |
