Claims
- 1. A compound having the formula: ##STR24## wherein x has a value of 1, 2 or 3, R.sub.1 is a lower alkyl group, R.sub.2 is a member selected from the group consisting of hydrogen, alkyl radicals having from one to 12 carbon atoms, alkenyl radicals having from two to 15 carbon atoms, cycloalkyl radicals having from three to 20 carbon atoms, aralkyl and alkaryl radicals having from seven to 20 carbon atoms, a halogen radical, provided that when x has a value of 1 and R.sub.2 is in the para position and R.sub.3 and R.sub.4 are both hydrogen, R.sub.2 is not chlorine; hydroxyl, amino, thiol, nitro, alkoxy, aryloxy, carboxyl, alkylcarboxyl radicals having from one to 10 carbon atoms, alkylthio and arylthio radicals having from one to 20 carbon atoms, a sulfonic acid group, alkylsulfonyl and arylsulfonyl radicals having from one to 20 carbon atoms, alkylsulfinyl and arylsulfinyl radicals having from one to 20 carbon atoms, alkylamino and arylamino radicals having from one to 20 carbon atoms, and, when taken together with the aromatic ring to which it is attached, naphthyl; and R.sub.4 is hydrogen or a lower alkyl group.
- 2. A compound as defined in claim 1 wherein R.sub.1 is ethyl.
- 3. A compound as defined in claim 2 wherein R.sub.4 is hydrogen and the group ##STR25## is selected from those having the following structures: C.sub.6 H.sub.5, 4-CH.sub.3 C.sub.6 H.sub.4, 2,4-(CH.sub.3).sub.2 C.sub.6 H.sub.3, 3,4-(CH.sub.3).sub.2 C.sub.6 H.sub.3, 4-FC.sub.6 H.sub.4, 2,4-(Cl).sub.2 C.sub.6 H.sub.3, 3,4-(Cl).sub.2 C.sub.6 H.sub.3, 3-CH.sub.3 OC.sub.6 H.sub.4, 4-CH.sub.3 OC.sub.6 H.sub.4, 3,4,5-(CH.sub.3 O).sub.3 C.sub.6 H.sub.2, 4-O.sub.2 NC.sub.6 H.sub.4, 4-CF.sub.3 C.sub.6 H.sub.4, and 2-C.sub.10 H.sub.7.
- 4. A compound as defined in claim 2 wherein R.sub.2 is hydrogen and R.sub.4 is methyl.
- 5. A compound having the formula: ##STR26## wherein x has a value of 1, 2 or 3, R.sub.1 is a lower alkyl group, R.sub.2 is a member selected from the group consisting of hydrogen, alkyl radicals having from one to 12 carbon atoms, alkenyl radicals having from two to 15 carbon atoms, cycloalkyl radicals having from three to 20 carbon atoms, aralkyl and alkaryl radicals having from seven to 20 carbon atoms, a halogen radical, provided that when x has a value of 1 and R.sub.2 is in the para position and R.sub.3 and R.sub.4 are both hydrogen, R.sub.2 is not chlorine; hydroxyl, amino, thiol, nitro, alkoxy, aryloxy, carboxyl, alkylcarboxyl radicals having from one to 10 carbon atoms, alkylthio and arylthio radicals having from one to 20 carbon atoms, a sulfonic acid group, alkylsulfonyl and arylsulfonyl radicals having from one to 20 carbon atoms, alkylsulfinyl and arylsulfinyl radicals having from one to 20 carbon atoms, alkylamino and arylamino radicals having from one to 20 carbon atoms, and, when taken together with the aromatic ring to which it is attached, naphthyl; and R.sub.3 is hydrogen or a lower alkyl group.
- 6. A compound as defined in claim 5 wherein R.sub.1 is ethyl, R.sub.2 is hydrogen and R.sub.3 is methyl.
- 7. A compound having the formula: ##STR27## wherein x has a value of 1, 2 or 3, R.sub.1 is a lower alkyl group, R.sub.2 is a member selected from the group consisting of hydrogen, alkyl radicals having from one to 12 carbon atoms, alkenyl radicals having from two to 15 carbon atoms, cycloalkyl radicals having from three to 20 carbon atoms, aralkyl and alkaryl radicals having fom seven to 20 carbon atoms, a halogen radical, provided that when x has a value of 1 and R.sub.2 is in the para position and R.sub.3 and R.sub.4 are both hydrogen, R.sub.2 is not chlorine; hydroxyl, amino, thiol, nitro, alkoxy, aryloxy, carboxyl, alkylcarboxyl radicals having from one to 10 carbon atoms, alkylthio and arylthio radicals having from one to 20 carbon atoms, sulfonic acid group, alkylsulfonyl and arylsulfonyl radicals having from one to 20 carbon atoms, alkylsulfinyl and arylsulfinyl radicals having from one to 20 carbon atoms, alkylamino and arylamino radicals having from one to 20 carbon atoms, and, when taken together with the aromatic ring to which it is attached, naphthyl; and R.sub.3 and R.sub.4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.
- 8. A compound as defined in claim 7 wherein R.sub.1 is ethyl.
- 9. A compound as defined in claim 8 wherein R.sub.3 and R.sub.4 are each hydrogen and the group ##STR28## is selected from those having the following structures: C.sub.6 H.sub.5, 4-CH.sub.3 C.sub.6 H.sub.4, 3,4-(CH.sub.3).sub.2 C.sub.6 H.sub.3, 4-FC.sub.6 H.sub.4, 3,4-(Cl).sub.2 C.sub.6 H.sub.3, 3-CH.sub.3 OC.sub.6 H.sub.4, 4-CH.sub.3 OC.sub.6 H.sub.4, 3,4,5-(CH.sub.3 O).sub.3 C.sub.6 H.sub.2, 4-O.sub.2 NC.sub.6 H.sub.4, 4-CF.sub.3 C.sub.6 H.sub.4 and 2-C.sub.10 H.sub.7.
- 10. A compound as defined in claim 8 wherein R.sub.2 and R.sub.4 are each hydrogen and R.sub.3 is methyl.
- 11. A compound as defined in claim 8 wherein R.sub.2 and R.sub.3 are each hydrogen and R.sub.4 is methyl.
CROSS-REFERENCES TO RELATED APPLICATIONS
This is a division of application Ser. No. 354,164 filed Mar. 3, 1982, now Pat. No. 4,450,160 which is a continuation-in-part of our abandoned application Ser. No. 327,928, filed Dec. 7, 1981, which is a continuation-in-part of abandoned application Ser. No. 247,158, filed Mar. 24, 1981.
Non-Patent Literature Citations (7)
Entry |
Temple, Jr., "Abstract, 28th SE Regional Meeting of ACS", Oct. 27-29, 1976, p. 424. |
Elliot et al., J. Org. Chem. 36, 2818 (1971). |
Elliot et al., J. Med. Chem. 17, 553 (1974). |
Wilson et al., Federation Proceedings, 33, 158 (1974). |
Davidse et al., J. Cell. Biol. 72, 174 (1977). |
Montgomery et al., J. Org. Chem. 29, 734 (1964). |
Elliot, J. Org. Chem. 33, 533 (1968). |
Divisions (1)
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Number |
Date |
Country |
Parent |
354164 |
Mar 1982 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
327928 |
Dec 1981 |
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Parent |
247158 |
Mar 1981 |
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