Claims
- 1. A process for the preparation of optically active alpha-arylalkanoic acid of formula ##STR13## wherein Ar represents an aryl group optionally substituted by 1 to 3 substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 haloalkoxy, or phenyl, phenoxy, benzoyl, and halogen atoms, each aromatic radical being optionally substituted by 1 or 2 substituents selected from the group consisting of halogen atoms, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; and R.sub.1 represents a C.sub.1 -C.sub.4 alkyl which process comprises rearrangement of an optically active compound of the formula: ##STR14## wherein R represents a methyl or phenyl group and X represents a chlorine, bromine or iodine atom;
- said rearrangement being performed by treatment with (1) a soft or border line Lewis acid; (2) a mixture of a polar aprotic solvent with a protic solvent having a high dielectric constant; or (3) water at acidic pH.
Priority Claims (1)
Number |
Date |
Country |
Kind |
22825 A/86 |
Dec 1986 |
ITX |
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Parent Case Info
This is a division of application Ser. No. 07/135,086 filed Dec. 18, 1987 now U.S. Pat. No. 4,845,243.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0214426 |
Mar 1987 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
135086 |
Dec 1987 |
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