Claims
- 1. A compound of the formula ##STR119## wherein R.sub.1 is alkyl of 1 to 6 carbon atoms, unsubstituted or monosubstituted by hydroxy, amino, alkanoylamino of 1 to 6 carbon atoms, benzyloxycarbonylamino, or p-nitrobenzyloxycarbonylamino; phenyl; or phenyl substituted by one or more members selected from the group consisting of halo, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, amino alkanoylamino of 1 to 6 carbon atoms, benzyloxycarbonylamino or p-nitrobenzyloxycarbonylamino;
- R is alkyl of 1 to 6 carbon atoms, benzyl, p-nitrobenzyl, p-methoxybenzyl, phenacyl, p-bromophenacyl, 2,2,2-trichloroethyl, phthalidyl, phthalimidomethyl, .alpha.-ethoxycarbonylethyl or alkanoyloxymethyl of 1 to 6 carbon atoms, and
- G is hydrogen, alkyl or alkenyl, said alkyl and alkenyl being unsubstituted or substituted by hydroxy, oxo, methoxycarbonyl, phenyl or phenyl substituted by alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro or halo.
- 2. A compound according to claim 1 wherein G is prop-2-en-1-yl,3-methylbut-2-en-1-yl or pent-2-en-1-yl.
- 3. A compound according to claim 1 wherein G is 4-oxopent-2-en-1-yl or 3-methoxy-carbonylprop-2-enyl.
- 4. A compound according to claim 1 wherein R.sub.1 is alkanoylamino of 1 to 6 carbon atoms, benzyloxycarbonylamino or p-nitrobenzyloxycarbonylamino.
- 5. A compound according to claim 1 wherein R.sub.1 is 2-acetamidoethyl, phenyl, p-acetamidophenyl, ethyl, propyl butyl or tertiary alkyl.
- 6. A compound according to claim 1 wherein G is hydrogen.
- 7. A compound according to claim 1 wherein R is alkyl of 1 to 6 carbon atoms, benzyl, p-nitrobenzyl, p-methoxybenzyl, phenacyl, p-bromophenacyl, 2,2,2-trichloroethyl, pthalidyl, phtalimidomethyl, .alpha.-ethoxycarbonyloxyethyl, pivaloyloyxymethyl or acetoxymethyl.
- 8. The compound according to claim 1 which is methyl 7-oxo-3-ethylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 9. The compound according to claim 1 which is benzyl 7-oxo-3-phenylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 10. The compound according to claim 1 which is benzyl 7-oxo-3-ethylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 11. The compound according to claim 1 which is benzyl 3-acetylaminoethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 12. The compound according to claim 1 which is benzyl 3-(4'-acetamidophenyl)thio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 13. The compound according to claim 1 which is benzyl 3-t-butylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 14. Benzyl 3-nitroethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 15. The compound according to claim 1 which is benzyl 3-(2'-hydroxyethyl)thio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 16. Benzyl 7-oxo-3-tritylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 17. Benzyl 7-oxo-3-tritylaminoethylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 18. The compound according to claim 1 which is 4-nitrobenzyl 3-ethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 19. The compound according to claim 1 which is 4-nitrobenzyl 3-acetylaminoethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 20. 4-Nitrobenzyl 7-oxo-3-tritylaminoethylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 21. The compound according to claim 1 which is 4-nitrobenzyl 3-(4'-nitrobenzyloxycarbonylaminoethylthio)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 22. The compound according to claim 1 which is benzyl 6-(2-hydroxy-2-propyl)-3-ethylthio-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 23. The compound according to claim 1 which is benzyl 6-(1-hydroxyethyl)-7-oxo-3-phenylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 24. The compound according to claim 1 which is phthalidyl 6-(1-hydroxyethyl)-7-oxo-3-phenylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 25. The compound according to claim 1 which is benzyl 6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-3-phenylthio-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 26. The compound according to claim 1 which is p-bromophenacyl 3-ethylthio-6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 27. The compound according to claim 1 which is phthalidyl 3-ethylthio-6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 28. The compound according to claim 1 which is 2,2,2-trichloroethyl 3-(2',4',5',-trichlorophenyl)thio-6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
- 29. The compound according to claim 1 which is p-bromophenacyl 3-butylthio-6-(3-methoxycarbonylprop-2-ene-1-yl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
47201/77 |
Dec 1977 |
GBX |
|
Parent Case Info
This is a divisional of my copending application, Ser. No. 955,598, filed Oct. 30, 1978, now U.S. Pat. No. 4,223,038, issued Sept. 16, 1980.
US Referenced Citations (4)
Divisions (1)
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Number |
Date |
Country |
Parent |
955598 |
Oct 1978 |
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