Claims
- 1. In the process for the preparation of demethylepipodophyllotoxin-.beta.-glucosides in which a glucose derivative and a demethylepipodophyllotoxin derivative are allowed to react in the presence of a Lewis acid, the improvement which comprises allowing a glucose derivative of the formula: ##STR5## in which the two R.sup.1 groups together are alkylidene, arylalkylidene, or heteroarylalkylidene, R.sup.2 is lower alkanoyl or haloacetyl, and R.sup.3 is trialkylsilyl, to react with demethylepipodophyllotoxin.
- 2. The process according to claim 1 wherein the two R.sup.1 groups together are ethylidene.
- 3. The process according to claim 2 wherein and each R.sup.2 is formyl.
- 4. The process according to claim 2 wherein and each R.sup.2 is dichloroacetyl.
- 5. The process according to claim 1 wherein the two groups together are thenylidene.
- 6. The process according to claim 5 wherein and each R.sup.2 is formyl.
- 7. The process according to claim 5 wherein and each R.sup.2 is dichloroacetyl.
Parent Case Info
This is a continuation of Ser. No. 08/178,340, filed as PCT/EP92/01605, Jul. 15, 1992, now abandoned.
US Referenced Citations (11)
Non-Patent Literature Citations (2)
Entry |
Corey et al., Journal of the Amer. Chem. Soc., vol.94 (17) : 6190-6191, (1972). |
Lolonde and Chan, Synthesis, pp. 817-843, (1985). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
178340 |
Feb 1994 |
|