Intervertebral implant

Information

  • Patent Grant
  • 11497618
  • Patent Number
    11,497,618
  • Date Filed
    Wednesday, January 9, 2019
    5 years ago
  • Date Issued
    Tuesday, November 15, 2022
    a year ago
Abstract
An adjustable spinal fusion intervertebral implant is provided that can comprise upper and lower body portions that can each have proximal and distal wedge surf aces disposed at proximal and distal ends thereof. An actuator shaft disposed intermediate the upper and lower body portions can be actuated to cause proximal and distal protrusions to converge towards each other and contact the respective ones of the proximal and distal wedge surfaces. Such contact can thereby transfer the longitudinal movement of the proximal and distal protrusions against the proximal and distal wedge surfaces to cause the separation of the upper and lower body portions, thereby expanding the intervertebral implant. The upper and lower body portions can have side portions that help facilitate linear translational movement of the upper body portion relative to the lower body portion.
Description
BACKGROUND
Field of the Invention

The present invention relates to medical devices and, more particularly, to an intervertebral implant.


Description of the Related Art

The human spine is a flexible weight bearing column formed from a plurality of bones called vertebrae. There are thirty three vertebrae, which can be grouped into one of five regions (cervical, thoracic, lumbar, sacral, and coccygeal). Moving down the spine, there are generally seven cervical vertebra, twelve thoracic vertebra, five lumbar vertebra, five sacral vertebra, and four coccygeal vertebra. The vertebra of the cervical, thoracic, and lumbar regions of the spine are typically separate throughout the life of an individual. In contrast, the vertebra of the sacral and coccygeal regions in an adult are fused to form two bones, the five sacral vertebra which form the sacrum and the four coccygeal vertebra which form the coccyx.


In general, each vertebra contains an anterior, solid segment or body and a posterior segment or arch. The arch is generally formed of two pedicles and two laminae, supporting seven processes—four articular, two transverse, and one spinous. There are exceptions to these general characteristics of a vertebra. For example, the first cervical vertebra (atlas vertebra) has neither a body nor spinous process. In addition, the second cervical vertebra (axis vertebra) has an odontoid process, which is a strong, prominent process, shaped like a tooth, rising perpendicularly from the upper surface of the body of the axis vertebra. Further details regarding the construction of the spine may be found in such common references as Gray's Anatomy, Crown Publishers, Inc., 1977, pp. 33-54, which is herein incorporated by reference.


The human vertebrae and associated connective elements are subjected to a variety of diseases and conditions which cause pain and disability. Among these diseases and conditions are spondylosis, spondylolisthesis, vertebral instability, spinal stenosis and degenerated, herniated, or degenerated and herniated intervertebral discs. Additionally, the vertebrae and associated connective elements are subject to injuries, including fractures and torn ligaments and surgical manipulations, including laminectomies.


The pain and disability related to the diseases and conditions often result from the displacement of all or part of a vertebra from the remainder of the vertebral column. Over the past two decades, a variety of methods have been developed to restore the displaced vertebra to their normal position and to fix them within the vertebral column. Spinal fusion is one such method. In spinal fusion, one or more of the vertebra of the spine are united together (“fused”) so that motion no longer occurs between them. Thus, spinal fusion is the process by which the damaged disc is replaced and the spacing between the vertebrae is restored, thereby eliminating the instability and removing the pressure on neurological elements that cause pain.


Spinal fusion can be accomplished by providing an intervertebral implant between adjacent vertebrae to recreate the natural intervertebral spacing between adjacent vertebrae. Once the implant is inserted into the intervertebral space, osteogenic substances, such as autogenous bone graft or bone allograft, can be strategically implanted adjacent the implant to prompt bone ingrowth in the intervertebral space. The bone ingrowth promotes long-term fixation of the adjacent vertebrae. Various posterior fixation devices (e.g., fixation rods, screws etc.) can also be utilize to provide additional stabilization during the fusion process.


Recently, intervertebral implants have been developed that allow the surgeon to adjust the height of the intervertebral implant. This provides an ability to intra-operatively tailor the intervertebral implant height to match the natural spacing between the vertebrae. This reduces the number of sizes that the hospital must keep on hand to match the variable anatomy of the patients.


In many of these adjustable intervertebral implants, the height of the intervertebral implant is adjusted by expanding an actuation mechanism through rotation of a member of the actuation mechanism. In some intervertebral implants, the actuation mechanism is a screw or threaded portion that is rotated in order to cause opposing plates of the implant to move apart. In other implants, the actuation mechanism is a helical body that is counter-rotated to cause the body to increase in diameter and expand thereby.


Furthermore, notwithstanding the variety of efforts in the prior art described above, these intervertebral implants and techniques are associated with another disadvantage. In particular, these techniques typically involve an open surgical procedure, which results higher cost, lengthy in-patient hospital stays and the pain associated with open procedures.


Therefore, there remains a need in the art for an improved intervertebral implant. Preferably, the implant is implantable through a minimally invasive procedure. Further, such devices are preferably easy to implant and deploy in such a narrow space and opening while providing adjustability and responsiveness to the clinician.


SUMMARY OF THE INVENTION

Accordingly, one embodiment of the present invention comprises a spinal fusion intervertebral implant that includes upper and lower body portions and an actuator shaft that can be sized and configured to be received therebetween. The upper and lower body portions can each have proximal surfaces disposed at proximal ends thereof. The actuator shaft can comprise an inner member and an outer sleeve member adapted to be translatable relative to the inner member. The inner member can have distal and proximal ends and at least one retention structure disposed therebetween. The outer sleeve member can have a proximal end and at least one complementary retention structure being sized and configured to engage the retention structure of the inner member to facilitate selective relative movement of the proximal end of the outer sleeve member toward the distal end of the inner member without rotation.


Further, the intervertebral implant can also include at least one proximal wedge member which can be disposed at the proximal end of the outer sleeve member. The proximal protrusion can be sized and configured to contact the proximal surfaces of the upper and lower body portions upon selective relative movement of the proximal end of the outer sleeve member toward the distal end of the inner member. The longitudinal movement of the proximal wedge member against the proximal surfaces can cause the separation of the upper and lower body portions.


In accordance with another embodiment, a spinal fusion intervertebral implant is provided that comprises upper and lower body portions each having proximal and distal surfaces at proximal and distal ends thereof. The proximal and distal surfaces of the upper and lower body portions can be configured to generally face each other. The implant can further comprise an actuator shaft received between the upper and lower body portions. The actuator shaft can comprise an inner member and an outer sleeve member selectively moveable relative to the inner member. The implant can further comprise a distal wedge member disposed at a distal end of the inner member. The distal wedge member can have an engagement surface configured to provide ratchet-type engagement with the distal surfaces of the upper and lower body portions upon selective relative movement of the distal end of the inner member toward the proximal end of the outer sleeve member. Further, the implant can comprise a proximal wedge member disposed at a proximal end of the outer sleeve member. The proximal wedge member can have an engagement surface configured to provide ratchet-type engagement with the proximal surfaces of the upper and lower body portions upon selective relative movement of the proximal end of the outer sleeve member toward the distal end of the inner member. In such an embodiment, longitudinal movement of the distal wedge member against the distal surfaces and the longitudinal movement of the proximal wedge member against the proximal surfaces can cause separation of the upper and lower body portions. Furthermore, the ratchet-type engagement between the distal and proximal wedge members and the respective ones of the proximal and distal surfaces of the upper and lower body portions can maintain separation of the upper and lower body portions.


In accordance with yet another embodiment, a method of implanting a implant is also provided. The method can comprise the steps of positioning the implant between two vertebral bodies and moving an inner member of an actuator shaft of the implant in an proximal direction relative to an outer sleeve member disposed about the inner sleeve member to force a proximal protrusion of the outer sleeve member against proximal surfaces of respective ones of upper and lower body portions of the implant to separate the upper and lower body portions to cause the implant to expand intermediate the vertebral bodies.


In accordance with yet another embodiment, a method of implanting a implant is also provided. The method can comprise the steps of positioning the implant between two vertebral bodies and rotating a screw mechanism of the implant to cause proximal and distal wedge members to converge toward each other and engage respective ones of proximal and distal surfaces of upper and lower body portions of the implant to separate the upper and lower body portions to cause the implant to expand.


In accordance with yet another embodiment, an adjustable spinal fusion intervertebral implant is provided that comprises upper and lower body portions, proximal and distal wedge members, and a pin.


The upper and lower body portions can each have proximal and distal surfaces at proximal and distal ends thereof. The proximal and distal surfaces of the upper and lower body portions can generally face each other. The proximal surfaces of the respective ones of the upper and lower body portions can each define a proximal slot therein. The distal surfaces of the respective ones of the upper and lower body portions can each define a distal slot therein.


The proximal wedge member can be disposed at the proximal ends of the respective ones of the upper and lower body portions. The proximal wedge member can comprise upper and lower guide members extending at least partially into the respective ones of the proximal slots of the upper and lower body portions with at least a portion of the proximal wedge member contacting the proximal surfaces of the upper and lower body portions. The distal wedge member can be disposed at the distal ends of the respective ones of the upper and lower body portions. The distal wedge member can comprise upper and lower guide members extending at least partially into the respective ones of the distal slots of the upper and lower body portions with at least a portion of the distal wedge member contacting the distal surfaces of the upper and lower body portions.


The actuator shaft can be received between the upper and lower body portions. The actuator shaft can extend intermediate the distal and proximal wedge members, wherein rotation of the actuator shaft causes the distal and proximal wedge members to be drawn together such that longitudinal movement of the distal wedge member against the distal surfaces and the longitudinal movement of the proximal wedge member against the proximal surfaces causes separation of the upper and lower body portions.


In such an embodiment, the upper body portion can further comprise a pair of downwardly extending side members and the lower body portion further comprises a pair of upwardly extending side members. The side members of the upper body portion can engage the side members of the lower body portion to facilitate linear translational movement of the upper body portion relative to the lower body portion. The side members of the upper body portion can each comprise a slot and the side members of the lower body portion each comprise a guide member. The guide members of the side members of the lower body portion can each be received into the slots of the side members of the upper body portion.


The implant can be configured wherein the proximal and distal surfaces of the upper and lower body portions are sloped. The slots of the proximal and distal surfaces of the upper and lower body portions can also be sloped. Further, the slots of the proximal and distal surfaces of the upper and lower body portions can be generally parallel to the respective proximal and distal surfaces of the upper and lower body portions. In other embodiments, the slots of the proximal and distal surfaces of the upper and lower body portions can be generally dove-tailed. The guide members of the proximal and distal wedge members can also be generally dovetailed. In other embodiments, the upper and lower body portions can comprise generally arcuate respective upper and lower exterior engagement surfaces.


The proximal wedge member can comprise an anti-rotational element. The anti-rotational engagement can be configured to be engaged by an implant tool for preventing rotation of the implant when the actuator shaft is rotated relative to the implant. The anti-rotational element can comprise a pair of apertures extending into the proximal wedge member.


In yet another embodiment, an implantation tool is provided for implanting an expandable intervertebral implant. The tool can comprise a handle section, a distal engagement section, and an anti-rotational engagement member. The handle section can comprise a fixed section and first and second rotatable members. The distal engagement section can comprise a fixed portion and first and second rotatable portions being operatively coupled to the respective ones of the first and second rotatable members. The first rotatable portion can comprise a distal attachment element. The distal engagement element can be operative to be removably attached to a distal end of at least a portion of the implant. The second rotatable portion can comprise a distal engagement member being configured to engage a proximal end of an actuator shaft of the implant for rotating the actuator shaft to thereby and expanding the implant from an unexpanded state to and expanded state. The anti-rotational engagement member can be used to engage an anti-rotational element of the implant.


In some embodiments, the first and second rotatable members of the tool can be coaxially aligned. Further, the first and second rotatable portions can be coaxially aligned. The first and second rotatable portions can be tubular, and the first rotatable portion can be disposed internally to the second rotatable portion. The fixed portion of the distal engagement section can be tubular and the first and second rotatable portions can be disposed internally to the fixed portion.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 is a side view of an intervertebral implant in an unexpanded state while positioned intermediate adjacent vertebrae, according to an embodiment.



FIG. 2 is a side view of the intervertebral implant shown in FIG. 1 in an expanded state.



FIG. 3 is a perspective view of the intervertebral implant shown in FIG. 1 in an unexpanded state.



FIG. 4 is a perspective view of the intervertebral implant shown in FIG. 3 in an expanded state.



FIG. 5 is a side cross sectional view of the intervertebral implant shown in FIG. 3 in an unexpanded state.



FIG. 6 is a side cross-sectional view of the intervertebral implant shown in FIG. 5 in an expanded state.



FIG. 7 is a side cross-sectional view of the intervertebral implant shown in FIG. 5 in an expanded state and wherein a portion of an actuator shaft has been removed.



FIG. 8 is a side cross sectional view of another embodiment of the actuator shaft of the intervertebral implant shown in FIG. 3, wherein the actuator shaft has an outer sleeve member and an inner sleeve member.



FIG. 9A is a side perspective view of a portion of a modified embodiment of the outer sleeve member.



FIG. 9B is an enlarged longitudinal cross-sectional view of a modified embodiment of the outer sleeve member with the portion shown in FIG. 9A.



FIG. 9C is a perspective view of another embodiment of an outer sleeve member.



FIGS. 9D and 9E are enlarged views of a portion of one embodiment of an outer sleeve member.



FIG. 9F is a front view of the outer sleeve member shown in FIG. 9C.



FIG. 10A is a side cross sectional view of another embodiment of an intervertebral implant.



FIG. 10B is an enlarged view of the section 10B shown in FIG. 10A.



FIG. 11 is a side cross-sectional view of another embodiment of an actuator shaft of the intervertebral implant shown in FIG. 10A.



FIG. 12 is a perspective view of the embodiment of the intervertebral implant shown in FIG. 10A in an unexpanded state.



FIG. 13 is a perspective view of the embodiment of the intervertebral implant shown in FIG. 10A in an expanded state.



FIG. 14A is a side view of another embodiment of the intervertebral implant wherein the upper and lower body portions have generally slanted configurations.



FIG. 14B is a top view of another embodiment of the intervertebral implant wherein the upper and lower body portions have semicircular upper and lower faces.



FIG. 14C is a top view of another embodiment of the intervertebral implant wherein the upper and lower body portions have generally square upper and lower faces.



FIG. 14D is a top view illustrating an embodiment of an application of the intervertebral implant utilizing a plurality of intervertebral implants disposed in an intervertebral space to support adjacent vertebrae.



FIG. 15 is a side cross-sectional view of another embodiment of the intervertebral implant wherein rotational movement can be utilized to expand the implant.



FIG. 16A is a perspective view of another embodiment of an intervertebral implant in an unexpanded state.



FIG. 16B is a perspective view of the intervertebral implant shown in FIG. 16A wherein the implant is in an expanded state.



FIG. 17 is a bottom view of the intervertebral implant shown in FIG. 16A.



FIG. 18 is a side view of the intervertebral implant shown in FIG. 16B.



FIG. 19 is a front cross-sectional view of the intervertebral implant shown in FIG. 16B taken along lines 19-19.



FIG. 20A is a bottom perspective view of a lower body portion of the intervertebral implant shown in FIG. 16A.



FIG. 20B is a top perspective view of the lower body portion of the intervertebral implant shown in FIG. 16A.



FIG. 21A is a bottom perspective view of an upper body portion of the intervertebral implant shown in FIG. 16A.



FIG. 21B is a top perspective view of the upper body portion of the intervertebral implant shown in FIG. 16A.



FIG. 22 is a perspective view of an actuator shaft of the intervertebral implant shown in FIG. 16A.



FIG. 23A is a front perspective view of a proximal wedge member of the intervertebral implant shown in FIG. 16A.



FIG. 23B is a rear perspective view of the proximal wedge member of the intervertebral implant shown in FIG. 16A.



FIG. 24A is a front perspective view of a distal wedge member of the intervertebral implant shown in FIG. 16A.



FIG. 24B is a rear perspective view of the distal wedge member of the intervertebral implant shown in FIG. 16A.



FIG. 25 is a perspective view of a deployment tool according to an embodiment.



FIG. 26 is a side cross-sectional view of the deployment tool shown in FIG. 25 wherein an expandable implant is attached to a distal end thereof.





DETAILED DESCRIPTION

In accordance with certain embodiments disclosed herein, an improved intervertebral implant is provided that allows the clinician to insert the intervertebral implant through a minimally invasive procedure. For example, in one embodiment, one or more intervertebral implants can be inserted percutaneously to reduce trauma to the patient and thereby enhance recovery and improve overall results of the surgery.


For example, in one embodiment, an intervertebral implant includes a plurality of body sections that are selectively separable and expandable upon contraction of a centrally disposed actuator. The actuator can be utilized to contract against faces of the body sections to cause the expansion thereof. The implant can also be configured such that the actuator provides for both the expansion and contraction of the body sections. The actuator can comprise an interaction between the body sections and another element, an action performed by another element, or a combination of interactions between various elements of the implant and its body sections. Further, the implant can be configured to allow either rough or fine incremental adjustments in the expansion of the implant.


The embodiments disclosed herein are discussed in the context of an intervertebral implant and spinal fusion because of the applicability and usefulness in such a field. As such, various embodiments can be used to properly space adjacent vertebrae in situations where a disc has ruptured or otherwise been damaged. As also disclosed herein, embodiments can also be used as vertebral body replacements. Thus, “adjacent” vertebrae can include those originally separated only by a disc or those that are separated by intermediate vertebra and discs. Such embodiments can therefore tend to recreate proper disc height and spinal curvature as required in order to restore normal anatomical locations and distances. However, it is contemplated that the teachings and embodiments disclosed herein can be beneficially implemented in a variety of other operational settings, for spinal surgery and otherwise.


For example, the implant disclosed herein can also be used as a vertebral body replacement. In such a use, the implant could be used as a replacement for a lumbar vertebra, such as one of the L1-L5 vertebrae. Thus, the implant could be appropriately sized and configured to be used intermediate adjacent vertebrae, or to entirely replace a damaged vertebra.


It is contemplated that the implant can be used as an interbody or intervertebral device or can be used to replace a vertebral body entirely. The implant can also be used in veterbal body compression fractures. Further, the implant can be used as a tool to expand an intervertebral space or bone in order to fill the space or bone with a cement; in such cases, the implant can be removed or left in once the cement is placed. Furthermore, the implant can also be used as a tool to predilate disc space. In some embodiments, the implant can be removed once the disc space is dilated, and a different implant (expandable or non-expandable) can then be implanted in the dilated disc space. Finally, the implant can also be introduced into the disc space anteriorly in an anterior lumbar interbody fusion (ALIF) procedure, posterior in an posterior lumbar interbody fusion (PILF) or posterial lateral interbody fusion, from extreme lateral position in an extreme lateral interbody fusion procedure, and transforaminal lumbar interbody fusion (TLIF), to name a few. Although the implant is primarily described herein as being used to expand in a vertical direction, it can also be implanted to expand in a horizontal direction in order to increase stability and/or increase surface area between adjacent vertebral bodies.


Additionally, the implant can comprise one or more height change mechanisms to facilitate expansion of the implant. For example, the implant can use a classic wedge system, a parallel bar and linkage system, a jack system, a pair of inclined planes, a screw jack system, a cam system, a balloon and bellows system, a hydraulic or pneumatic system, a longitudinal deformation/crush system (in which longitudinal contraction creates vertical expansion), or a stacking system, to name a few. Furthermore, the implant can comprise one or more height retention mechanisms. For example, the implant can use a pin ratchet system, a wedge ratchet system, a lead screw system with left or right-hand threads, or a lead screw system with left and right-hand threads, to name a few.


Therefore, it is contemplated that a number of advantages can be realized utilizing various embodiments disclosed herein. For example, as will be apparent from the disclosure, no external distraction of the spine is necessary. Further, no distraction device is required in order to install various embodiments disclosed herein. In this regard, embodiments of the implant can enable sufficient distraction of adjacent vertebra in order to properly restore disc height or to use the implant as a vertebral body replacement. Thus, normal anatomical locations, positions, and distances can be restored and preserved utilizing many of the embodiments disclosed herein.


Referring to FIG. 1, there is illustrated a side view of an embodiment of a intervertebral implant 10 in an unexpanded state while positioned generally between adjacent vertebrae of the lumbar portion of the spine 12. FIG. 2 illustrates the intervertebral implant 10 in an expanded state, thereby supporting the vertebrae in a desired orientation and spacing in preparation for spinal fusion. As is known in the art, spinal fusion is the process by which the adjacent vertebrae of the spine are united together (“fused”) so that motion no longer occurs between the vertebrae. Thus, the intervertebral implant 10 can be used to provide the proper spacing two vertebrae to each other pending the healing of a fusion. See also U.S. Patent Publication No. 2004/0127906, filed Jul. 18, 2003, application Ser. No. 10/623,193, the entirety of the disclosure of which is hereby incorporated by reference.


According to an embodiment, the implant can be installed in an operation that generally entails the following procedures. The damaged disc or vertebra can be decompressed, such as by distracting. The subject portion (or entire) disc or vertebra can then be removed. The adjacent vertebrae can be prepared by scraping the exposed adjacent portion or plates thereof (typically to facilitate bleeding and circulation in the area). Typically, most of the nucleus of the disc is removed and the annulus of the disc is thinned out. Although individual circumstances may vary, it may be unusual to remove all of the annulus or to perform a complete diskectomy. The implant can then be installed. In some embodiments, distraction of the disc may not be a separate step from placement of the implant; thus, distraction can be accomplished and can occur during placement of the implant. Finally, after implantation of the implant, osteogenic substances, such as autogenous bone graft, bone allograft, autograft foam, or bone morphogenic protein (BMP) can be strategically implanted adjacent the implant to prompt bone ingrowth in the intervertebral space. In this regard, as the implant is expanded, the spaces within the implant can be backfilled; otherwise, the implant can be prepacked with biologics.


The intervertebral implant is often used in combination with posterior and/or anterior fixation devices (e.g., rods, plates, screws, etc. that span two or more vertebrae) to limit movement during the fusion process. U.S. Patent Publication No. 2004/0127906 discloses a particularly advantageous posterior fixation device and method which secures two adjacent vertebra to each other in a trans-laminar, trans-facet or facet-pedicle (e.g., the Boucher technique) application using fixation screws.


It should also be appreciated that in FIGS. 1 and 2 only one intervertebral implant 10 is shown positioned between the vertebrae 12. However, as will be discussed in more detail below, it is anticipated that two, three or more implants 10 can be inserted into the space between the vertebrae. Further, other devices, such as bone screws, can be used on the vertebrae as desired. For example, in a spinal fusion procedure, it is contemplated that one or more implants 10 can be used in conjunction with one or more bone screws and/or dynamic stabilization devices, such as those disclosed in the above-mentioned U.S. Patent Publication No. 2004/0127906, filed Jul. 18, 2003, application Ser. No. 10/623,193.


In another embodiment of use, the implant 10 can be used in combination with a dynamic stabilization devices such as those disclosed in U.S. Patent Publication No. 2006-0122609, filed Feb. 11, 2005, application Ser. No. 11/056,991; U.S. Patent Publication No. 2005/0033289, filed on May 6, 2004, now U.S. Pat. No. 6,951,561; U.S. Provisional Patent Application No. 60/942,998, filed on Jun. 8, 2007; U.S. Provisional Application No. 60/397,588 filed Jul. 19, 2002; U.S. Provisional Application No. 60/424,055, filed Nov. 5, 2002; Ser. No. 10/623,193; U.S. Provisional Application No. 60/397,588 filed Jul. 19, 2002 and Provisional Application 60/424,055 filed Nov. 5, 2002; the entireties of the disclosures of which are hereby incorporated by reference. In this manner, the implant 10 can be used to maintain height between vertebral bodies while the dynamic stabilization device provides limits in one or more degrees of movement.


The embodiment of the intervertebral implant 10 shown FIGS. 1 and 2 will now be described in more detail with reference FIGS. 3 and 4. FIG. 3 illustrates a perspective view the intervertebral implant 10 in an unexpanded state while FIG. 4 illustrates the intervertebral implant 10 in an expanded state. The intervertebral implant 10 can comprise an upper body portion 14 and a lower body portion 16. The upper and lower body portions 14, 16 can each have a proximally facing surface 18, 20 disposed at respective proximal ends 22, 24 thereof and generally facing each other. As will be explained below, the proximally facing surfaces 18, 20 can be inclined or otherwise curved with respect to the longitudinal axis of the body portions 14, 16.


In the illustrated embodiment, the upper and lower body portions 14, 16 are illustrated as being configured substantially as parallel plate like structures. As will be explained below, the upper and lower body portions 14, 16 can be variously configured and designed, such as being generally ovular, wedge-shaped, and other shapes. For example, instead of including smooth exterior surfaces, as shown, the upper and lower body portions 14, 16 can be configured to include a surface texture, such as one or more external teeth, in order to ensure that the intervertebral implant 10 is maintained in a given lateral position once expanded intermediate the adjacent vertebrae of the spine 12. Other such modifications can be implemented in embodiments disclosed herein, and may be readily understood by one of skill in the art.


The intervertebral implant 10 can further comprise an actuator shaft 30 that can be sized and configured to be received between the upper and lower body portions 14, 16. As described herein with respect to various embodiments, the actuator shaft 30 can be utilized not only to move the intervertebral implant 10 from the unexpanded to the expanded state, but also to maintain expansion of the intervertebral implant 10. The actuator shaft 30 can be utilized in several embodiments to provide numerous advantages, such as facilitating precise placement, access, and rapid deployment of the intervertebral implant 10.


As shown in FIGS. 5 and 6, the actuator shaft 30 can comprise an inner member 32 and an outer sleeve member 34. In accordance with an embodiment, the outer sleeve member 34 can be adapted to be translatable relative to the inner member 32 such that the distance between the distal end of the inner member 32 and the proximal end of the outer member 34 can be reduced or shortened. The inner member 32 can have a distal end 36, a proximal end 38, and at least one retention structure 40 disposed therebetween. The outer sleeve member 32 can also have a proximal end 42 and at least one complementary retention structure 44.


In general, the retention structures 40, 44 between the inner member 32 and the outer member 34 can be configured such that facilitate selective relative movement of the proximal end 42 of the outer sleeve member 34 with respect to the distal end 36 of the inner member 32. While permitting such selective relative movement, the structures 40, 44 are preferably configured to resist movement once the distance between the proximal end 42 of the outer sleeve member 34 with respect to the distal end 36 of the inner member 32 is set. As will be described below, the retention structures 40, 44 can comprise any of a variety threads or screw-like structures, ridges, ramps, and/or ratchet type mechanisms which those of skill in the art will recognize provide such movement.


In some embodiments, the movement of proximal end 42 of the outer sleeve member 34, which may be in a direction distal to the clinician, can be accomplished without rotation of the actuator shaft 30, or any portion thereof. Thus, some embodiments provide that the actuator shaft 30 can be advantageously moved to the engaged position using only substantially longitudinal movement along an axis of the actuator shaft 30. It is contemplated that this axial translation of the outer sleeve member 34 can aid the clinician and eliminate cumbersome movements such as rotation, clamping, or otherwise. In this regard, the clinician can insert, place, and deploy the intervertebral implant 10 percutaneously, reducing the size of any incision in the patient, and thereby improving recovery time, scarring, and the like. These, and other benefits are disclosed herein.


In accordance with another embodiment, the proximal end 38 of the actuator shaft 30 can also be provided with a structure 48 for permitting releasable engagement with an installation or a removal tool 50. The actuator shaft 30 can therefore be moved as required and the tool 50 can later be removed in order to eliminate any substantial protrusions from the intervertebral implant 10. This feature can allow the intervertebral implant 10 to have a discreet profile once implanted into the patient and thereby facilitate healing and bone growth, while providing the clinician with optimal control and use of the intervertebral implant 10.


For example, as shown in FIG. 5, structure 48 comprises interacting threads between the distal end of the tool 50 and the proximal end 38 of the inner member 32. In a modified embodiment, the structure 48 can comprise any of a variety of fixation devices (e.g., hooks, latches, threads, etc.) as will be apparent to those of skill in the art. The actuator shaft 30 can therefore be securely coupled to the tool 50 during implantation of the intervertebral implant 10. Once disposed in the intervertebral space, the clinician can grasp the tool 50 to maintain the inner member 32 of the actuator shaft 30 at a constant position while pushing the outer sleeve member 34 in the distal direction and/or pull on the tool to proximally retract the inner member 32 while maintaining the outer member 34 stationary. Thus, the clinician can effectuate movement of the actuator shaft 30 and/or apply a force the actuator shaft 30. As will be described further below, this movement can thereby cause the intervertebral implant 10 to move from the unexpanded to the expanded state.


Alternatively, the tool 50 can be omitted and/or combined with the actuator shaft 30 such that the actuator shaft 30 includes a proximal portion that extends proximally in order to allow the clinician to manipulate the actuator shaft 30 position, as described with respect to the tool 50. In such an embodiment, the actuator shaft 30 can be provided with a first break point to facilitate breaking a proximal portion of the actuator shaft 30 which projects proximally of the proximal end 42 of the outer sleeve member 34 following tensioning of the actuator shaft 30 and expansion of the intervertebral implant 10. The break point can comprise an annular recess or groove, which can provide a designed failure point if lateral force is applied to the proximal portion while the remainder of the attachment system is relatively securely fixed in the intervertebral space. At least a second break point can also be provided, depending upon the axial range of travel of the outer sleeve member 34 with respect to the inner member 32. Other features and embodiments can be implemented as described in U.S. Pat. No. 6,951,561, the disclosure of which is hereby incorporated by reference in its entirety.


The retention structures 40, 44 of the inner member 32 and the outer sleeve member 34 can thus permit proximal movement of the inner member 32 with respect to the outer sleeve member 34 but resist distal movement of the inner member 32 with respect to the outer sleeve member 34. As the outer sleeve member 34 moves in the distal direction, the complementary retention structures 44 can engage the retention structures 40 of the inner member 32 to allow advancement of the outer sleeve member 34 in a distal direction with respect to inner member 32, but which resist proximal motion of outer sleeve member with respect to inner member 32. This can result in one-way or ratchet-type movement. Thus, in such an embodiment, at least one of the complementary retention structures 44 and the retention structures can comprise a plurality of annular rings, ramps, or ratchet-type structures. As mentioned above, any of a variety of ratchet-type structures can be utilized.


The actuator shaft 30 can also be configured to include a noncircular cross section or to have a rotational link such as an axially-extending spline on the inner member 32 for cooperating with a complementary keyway on the outer sleeve member 34. In another embodiment, the retention structures 40, 44 can be provided on less than the entire circumference of the inner member 32 or outer sleeve member 34, as will be appreciated by those of skill in the art. Thus, ratchet structures can be aligned in an axial strip such as at the bottom of an axially extending channel in the surface of the inner member 32. In this manner, the outer sleeve member 34 can be rotated to a first position to bypass the retention structures 40, 44 during axial advancement and then rotated to a second position to engage the retention structures 40, 44.


In accordance with another embodiment, the retention structures 40 of the inner member 32 can comprise a plurality of threads, adapted to cooperate with the complimentary retention structures 44 on the outer sleeve member 34, which may be a complimentary plurality of threads. In such an embodiment, the outer sleeve member 34 can be distally advanced along the inner member 32 by rotation of the outer sleeve member 34 with respect to the inner member 32, thus causing expansion of the intervertebral implant 10. The outer sleeve member 34 can also advantageously be removed from the inner member 32 by reverse rotation, such as to permit contraction of the intervertebral implant 10 to the unexpanded state in order to adjust the position thereof within the intervertebral space or to facilitate the removal of the intervertebral implant 10 from the patient.


For such a purpose, the outer sleeve member 34 can be preferably provided with a gripping configuration, structure, or collar 52 (see e.g., FIG. 7) to permit a removal instrument to rotate the outer sleeve member 34 with respect to the inner member 32. For example, such an instrument can be concentrically placed about the tool 50 and engage the collar 52. Thus, while holding the tool 50 in a fixed position, the clinician can reverse rotate the instrument to move the outer sleeve member 34 in a proximal direction. Any of a variety of gripping configurations may be provided, such as one or more slots, flats, bores, or the like. In the illustrated embodiment, the collar 52 can be provided with a polygonal, and in particular, a hexagonal circumference, as seen in FIGS. 7 and 8.


Various embodiments and/or additional or alternative components of the actuator shaft 30 and the retention structures 40, 44 can be found in U.S. Patent Publication 2004/0127906 (U.S. patent application Ser. No. 10/623,193, filed Jul. 18, 2003) entitled “METHOD AND APPARATUS FOR SPINAL FUSION”, which is hereby incorporated by reference. Additional embodiments and/or alternative components of the actuator shaft 30 can be found in U.S. patent application Ser. No. 60/794,171, filed on Apr. 21, 2006, U.S. Pat. Nos. 6,951,561, 6,942,668, 6,908,465, and 6,890,333, which are also incorporated by reference. For example, as described in U.S. Pat. No. 6,951,561, the actuator shaft 30 can be configured with particular spacing between the retention structures 40, 44; the actuator shaft 30 dimensions, such as diameter and cross-section, can be variously configured; and the actuator shaft 30 can be manufactured of various types of materials.



FIGS. 9A and 9B illustrate a portion of a modified embodiment of an outer sleeve member and inner member that is similar to the embodiments described above. In this embodiment, the outer sleeve member preferably includes a recess 54 configured to receive an annular ring 55. In an embodiment, the annular ring 55 can be a split ring (i.e., having a least one gap) and can be interposed between the inner member 32 and the proximal recess 54 of the outer sleeve member. In another embodiment, the ring 55 can be formed from an elastic material configured to ratchet over and engage with the inner member 32. In the split ring embodiment, the ring 55 comprises a tubular housing 56 that may be configured to engage with the inner member 32 and defines a gap or space 57. In one embodiment, the gap 57 is defined by a pair of edges 58, 59. The edges 58, 59 can be generally straight and parallel to each other. However, the edges 58, 59 can have any other suitable configuration and orientation.


For example, in one embodiment, the edges 58, 59 are curved and at an angle to each other. Although not illustrated, it should be appreciated that in modified embodiments, the ring 55 can be formed without a gap. When the ring 55 is positioned along the inner member 32, the ring 55 preferably surrounds a substantial portion of the inner member 32. The ring 55 can be sized so that the ring 55 can flex or move radially outwardly in response to an axial force so that the ring 55 can be moved relative to the inner member 32. In one embodiment, the tubular housing 56 includes at least one and in the illustrated embodiment four teeth or flanges 60, which are configured to engage the retention structures 40 on the inner member 32. In the illustrated embodiment, the teeth or flanges include a first surface that generally faces the proximal direction and is inclined with respect to the longitudinal axis of the outer sleeve member and a second surface that faces distal direction and lies generally perpendicular to the longitudinal axis of the outer sleeve member. It is contemplated that the teeth or flanges 60 can have any suitable configuration for engaging with the retention structures 40 of the inner member 32.


As with the previous embodiment, the outer sleeve member can includes the annular recess 54 in which the annular ring 55 may be positioned. The body 56 of the ring 55 can be sized to prevent substantial axial movement between the ring 55 and the annular recess 54 (FIG. 9B) during use of the outer sleeve member. In one embodiment, the width of the annular recess 54 in the axial direction is slightly greater than the width of the annular ring 55 in the axial direction. This tolerance between the annular recess 54 and the annular ring 55 can inhibit, or prevent, oblique twisting of the annular ring 55 so that the body 56 of the ring 55 is generally parallel to the outer surface of the inner member 32.


Further, the recess 54 can be sized and dimensioned such that as the outer sleeve member is advanced distally over the inner member 32, the annular ring 55 can slide along the first surface and over the complementary retention structures 40 of the inner member 32. That is, the recess 54 can provide a space for the annular ring 55 to move radially away from the inner member 32 as the outer sleeve member is advanced distally. Of course, the annular ring 55 can be sized and dimensioned such that the ring 55 is biased inwardly to engage the retention structures 40 on the inner member 32. The bias of the annular ring 55 can result in effective engagement between the flanges 60 and the retention structures 40.


A distal portion 61 of the recess 54 can be sized and dimensioned such that after the outer sleeve member 53 is appropriately tensioned the annular ring 55 becomes wedged between the inner member 32 and an angled engagement surface of the distal portion 61. In this manner, proximal movement of the outer sleeve member 53 can be prevented.



FIGS. 9C-9F illustrate another embodiment of an outer sleeve member 53′. In this embodiment, the outer sleeve member 53′ includes a recess 54 configured to receive a split ring 55, as described above with reference to FIGS. 9A and 9B. As will be explained in detail below, the outer sleeve member 53′ can include an anti-rotation feature to limit or prevent rotation of the ring 55 within the outer sleeve member 53. In light of the disclosure herein, those of skill in the art will recognize various different configurations for limiting the rotation of the ring 55. However, a particularly advantageous arrangement will be described below with reference to the illustrated embodiment.


In the illustrated embodiment, the outer sleeve member 53′ has a tubular housing 62 that can engage with the inner member 32 or the tool 50, as described above. With reference to FIGS. 9D and 9F, the tubular housing 62 can comprise one or more anti-rotational features 63 in the form of a plurality of flat sides that are configured to mate corresponding anti-rotational features 64 or flat sides of the inner member 32 of the actuator shaft 30. As shown in FIG. 9F, in the illustrated embodiment, the inner member 32 has three flat sides 64. Disposed between the flat sides 64 are the portions of the inner member 32 which include the complementary locking structures such as threads or ratchet like structures as described above. The complementary locking structures interact with the ring 55 as described above to resist proximal movement of the outer sleeve member 53′ under normal use conditions while permitting distal movement of the outer sleeve member 53′ over the inner member 32.


As mentioned above, the ring 55 can be is positioned within the recess 54. In the illustrated embodiment, the recess 54 and ring 55 are positioned near to and proximal of the anti-rotational features 63. However, the ring 55 can be located at any suitable position along the tubular housing 62 such that the ring 55 can interact with the retention features of the inner member 32.


During operation, the ring 55 may rotate to a position such that the gap 57 between the ends 58, 59 of the ring 55 lies above the complementary retention structures on the inner member 32. When the ring 55 is in this position, there is a reduced contact area between the split ring 55 the complementary retention structures thereby reducing the locking strength between the outer sleeve member 53′ and the inner member 32. In the illustrated embodiment, for example, the locking strength may be reduced by about ⅓ when the gap 57 over the complementary retention structures between flat sides 64. As such, it is advantageous to position the gap 57 on the flat sides 64 of the inner member 32 that do not include complementary retention structures.


To achieve this goal, the illustrated embodiment includes a pair of tabs 65, 66 that extend radially inward from the interior of the outer sleeve member 53′. The tabs 65, 66 are configured to limit or prevent rotational movement of the ring 55 relative to the housing 62 of the outer sleeve member 53′. In this manner, the gap 57 of the ring 55 may be positioned over the flattened sides 64 of the inner member 32.


In the illustrated embodiment, the tabs 65, 66 have a generally rectangular shape and have a generally uniform thickness. However, it is contemplated that the tabs 65, 66 can be square, curved, or any other suitable shape for engaging with the ring 55 as described herein.


In the illustrated embodiment, the tabs 65, 66 can be formed by making an H-shaped cut 67 in the tubular housing 62 and bending the tabs 65, 66 inwardly as shown in FIG. 9F. As shown in FIG. 9F, the tabs 65, 66 (illustrated in phantom) are interposed between the edges 58, 59 of the ring 55. The edges 58, 59 of the ring 55 can contact the tabs to limit the rotational movement of the ring 55. Those skilled in the art will recognize that there are many suitable manners for forming the tabs 65, 66. In addition, in other embodiments, the tabs 65, 66 may be replaced by a one or more elements or protrusions attached to or formed on the interior of the outer sleeve member 53′.


Referring again to FIGS. 3-6, the actuator shaft 30 can also comprise at least one proximal wedge member 68 being disposed at the proximal end 42 of the outer sleeve member 34. The proximal wedge member 68 can be sized and configured to contact the proximal facing surfaces 18, 20 of the upper and lower body portions 14, 16 upon selective relative movement of the proximal end 42 of the outer sleeve member 34 toward the distal end 36 of the inner member 32. The longitudinal movement of the proximal wedge member 68 against the proximal surfaces 18, 20 can cause the separation of the upper and lower body portions 14, 16 in order to cause the intervertebral implant 10 to expand from the unexpanded state to the expanded state, as shown in FIGS. 5 and 6, respectively.


As illustrated in FIGS. 3-6, the proximal wedge member 68 can be formed separately from the outer sleeve member 34. In such an embodiment, proximal wedge member 68 can be carried on a ring or wedge-type structure that is fitted around or over the outer sleeve member 34. In the illustrated embodiment, the proximal wedge member 68 can taper axially in the distal direction. For example, as shown in FIGS. 3 and 4, the proximal wedge member 68 can have a triangle-like structure that is disposed about the actuator shaft 30 and pushed against the proximal surfaces 18, 20 by the collar 52 of the outer sleeve member 34.


However, in other embodiments, as shown in FIG. 8, the proximal wedge member 68 can also be integrally formed with and/or permanently coupled to the outer sleeve member 34. Such an embodiment can be advantageous in that fewer parts are required, which can facilitate manufacturing and use of the intervertebral implant 10.


Preferably, the proximal surfaces 18, 20 of the upper and lower body portions 14, 16 are configured to substantially match the outer configuration of the proximal wedge member 68. The proximal surfaces 18, 20 can be integrally formed with the upper and lower body portions 14, 16 and have a shape that generally tapers toward the proximal ends 22, 24. The proximal surfaces 18, 20 can be defined by a smooth and constant taper, a non-constant curve, or a contact curve, or other geometries as may be appropriate.


For example, curvature proximal surfaces 18, 20 can be advantageous because initial incremental movement of the proximal wedge member 68 relative to the distal end 36 of the inner member 32 can result in relatively larger incremental distances between the upper and lower body portions 14, 16 than may subsequent incremental movement of the proximal wedge member 68. Thus, these types of adjustments can allow the clinician to quickly expand the intervertebral implant 10 to an initial expanded state with few initial incremental movements, but to subsequently expand the intervertebral implant 10 in smaller and smaller increments in order to fine tune the placement or expanded state of the intervertebral implant 10. Thus, such embodiments can allow the efficiency of the operation to be improved and allow the clinician to fine tune the expansion of the intervertebral implant 10.


With reference to FIGS. 1 and 5, in the illustrated embodiment, the upper and lower body portions 14, 16 can each have distally facing distal surfaces 70, 72 disposed at distal ends 74, 76 thereof, as similarly mentioned above with respect to the proximal surfaces 18, 20. For example, the distal surfaces 70, 72 can be inclined or otherwise curved with respect to the longitudinal axis of the body portions 14, 16. Other features, designs, and configurations of the proximal surfaces 18, 20, as disclosed herein, are not repeated with respect to the distal surfaces 70, 72, but it is understood that such features, designs, and configurations can similarly be incorporated into the design of the distal surfaces 70, 72.


In such an embodiment, the actuator shaft 30 of the intervertebral implant 10 can further comprise at least one distal wedge member 80 that can be disposed at the distal end 36 of the inner member 32. The distal wedge member 80 can be sized and configured to contact the distal surfaces 70, 72 of the respective ones of the upper and lower body portions 14, 16 upon selective relative movement of the distal end 36 of the inner member 32 toward the proximal end 42 of the outer sleeve member 34. As similarly described above with respect to the proximal wedge member 68, the longitudinal movement of the distal wedge member 80 against the distal surfaces 70, 72 can cause the separation of the upper and lower body portions 14, 16 thereby resulting in expansion of the intervertebral implant 10.


The description of the proximal wedge member 68 and its interaction with the proximal surfaces 18, 20, as well as the corresponding structures and embodiments thereof, can likewise be implemented with respect to the distal wedge member 80 and the distal surfaces 70, 72. Therefore, discussion of alternative embodiments, structures, and functions of the distal wedge member 80 and the distal surfaces 70, 72 need not be repeated in detail, but can include those mentioned above with respect to the distal wedge member 80 and the distal surfaces 70, 72.


In accordance with yet another embodiment illustrated in FIGS. 10A-11, at least one of the proximal and distal wedge members 68, 80 can be configured to include engagement surfaces 90, 92. The engagement surfaces 90, 92 can include any variety of surface textures, such as ridges, protrusions, and the like in order to enhance the engagement between the proximal and distal wedge members 68, 80 and the respective ones of the proximal and distal surfaces 18, 20 and 70, 72. In the embodiment illustrated in FIGS. 10A-11, the engagement surfaces 90, 92 can include stepped contours 94, 96, such as comprising a plurality of ridges.


As illustrated in the detail section view of FIG. 10B, the stepped contours 94, 96 of the engagement surfaces 90, 92 can be preferably configured to be inclined or oriented obliquely with respect to the axis of the actuator shaft 30. The use of the engagement surfaces 90, 92 can permit one-way, ratchet type longitudinal movement of proximal and distal wedge members 68, 80 relative to the proximal and distal surfaces 18, 20 and 70, 72 in order to maintain the upper and lower body portions 14, 16 at a given separation distance.


Additionally, at least one of the proximal and distal surfaces 18, 20 and 70, 72 of the upper and lower body portions 14, 16 can include complimentary engagement surfaces 100, 102, 104, 106. The complimentary engagement surfaces 100, 102, 104, 106 can similarly include any variety of surface textures, such as ridges, protrusions, and the like in order to enhance the engagement between the respective ones of the distal and proximal protrusions 68, 80.


In accordance with the embodiment shown in FIGS. 10A-11, the complimentary engagement surfaces 100, 102, 104, 106 can be configured as stepped contours 108, 110 and 112, 114, such as including a plurality of ridges. As shown best in the detail section view of FIG. 10, the stepped contours 108, 110, 112, 114 can also be configured to be inclined or oriented obliquely with respect to the axis of the actuator shaft 30. However, the stepped contours 108, 110, 112, 114 are preferably inclined in a direction opposite to the stepped contours 94, 96 of the proximal and distal wedge members 68, 80.


In such an embodiment, the stepped contours 108, 110, 112, 114 can engage the stepped contours 94, 96 of the wedge members 68, 80 to permit one-way ratcheting of the proximal and distal wedge members 68, 80 along the proximal and distal surfaces 18, 20, 70, 72. This advantageous feature can be incorporated into various embodiments disclosed herein in order to, inter alia, further improve the deployment and stabilization of the intervertebral implant 10.


As shown in FIG. 10A, in this embodiment, the inner member 32 and the outer sleeve member 34 do not include complementary retention structures as described above with reference to FIGS. 3 and 4. Thus, in this embodiment the inner members 32 can be moved with respect to the outer sleeve member 34, and the above-described engagement between the proximal and distal wedge members 68, 80 and the respective ones of the distal and proximal surfaces 18, 20 and 70, 72 can provide ratchet-type movement and maintain expansion of the implant 10. However, in modified embodiments, the retention structures 40, 44 of the actuator shaft 30 can also be provided in addition to the engagement of the proximal and distal wedge members 68, 80 and the respective ones of the distal and proximal surfaces 18, 20 and 70, 72.


Referring again to FIGS. 3 and 4, according to the illustrated embodiment, the intervertebral implant 10 can further comprise at least one alignment guide 120. The alignment guide 120 can be connected to the upper and lower body portions 14, 16 and be operative to facilitate separation of the first and second body portions 14, 16. As shown in FIGS. 3 and 4, the alignment guide 120 can comprise a plurality of guide rods 122 that are disposed through corresponding bores in the upper and lower body portions 14, 16. The rods 122 can be configured to orient the upper body portion 14 substantially orthogonally with respect to an axis of the actuator shaft 30 and with respect to the lower body portion 16. In such an embodiment, the rods 122 can each include a telescoping mechanism to enable and stabilize expansion of the intervertebral implant 30. Preferably, the alignment guide 120 also facilitates expansion or separation of the upper and lower body portions 14, 16 in a direction substantially orthogonal to an axis of the actuator shaft 30, such as in the axial direction of the rods 122.


In accordance with another embodiment illustrated in FIGS. 12 and 13, the alignment guide 120 can also be configured to include a first pair of side rails 130 extending from the upper body portion 14 toward the lower body portion 16 for aligning the upper body portion 14 with the lower body portion 16 to facilitate separation of the upper and lower body portions 14, 16 in a direction substantially orthogonal to an axis of the actuator shaft 30. Further, the alignment guide 120 can also include a second pair of side rails 132 extending from the lower body portion 16 toward the upper body portion 14 for cooperating with the first pair of side rails 130 in aligning the upper body portion 14 with the lower body portion 16 to facilitate separation of the upper and lower body portions 14, 16 in a direction substantially orthogonal to the axis of the actuator shaft 30.


As shown, the first and second pairs of side rails 130, 132 can be configured to extend substantially orthogonally from the respective ones of the upper and lower body portions 14, 16. In this regard, although the upper and lower body portions 14, 16 are illustrated as being configured substantially as parallel plates, any variety of configurations can be provided, such as generally ovular, wedge-shaped, and others, as mentioned above. Thus, the first and second pairs of side rails 130, 132 can be configured accordingly depending upon the configuration and design of the upper and lower body portions 14, 16.


For example, it is contemplated that the first and second pairs of side rails 130, 132 can be configured to ensure that the spacing between the proximal ends 22, 24 of the respective ones of the upper and lower body portions 14, 16 is equal to the spacing between the distal ends 74, 76 thereof. However, the first and second pairs of side rails 130, 132 can also be configured to orient exterior surfaces of the upper and lower body portions 14, 16 at an oblique angle relative to each other. Thus, the spacing between the proximal ends 22, 24 of the respective ones of the upper and lower body portions 14, 16 can be different from the spacing between the distal ends 74, 76 thereof. Thus, in one embodiment, such orientation can be created depending upon the desired configuration of the first and second pairs of side rails 130, 132.


Further, it is contemplated that the first and second pairs of side rails 130, 132 can be linear or planar in shape, as well as to generally conform to the shape of a curve in the longitudinal direction. Furthermore, the first and second pairs of side rails 130, 132 can also be configured to include mating surfaces to facilitate expansion and alignment of the intervertebral implant 10. Finally, the first and second pairs of side rails 130, 132, although illustrated as solid, can include perforations or other apertures to provide circulation through the intervertebral space.


In accordance with yet another embodiment, a method of implanting or installing the spinal fusion implant 10 is also provided. The method can comprise the steps of positioning the intervertebral implant 10 between two vertebral bodies and moving the inner member 32 of the actuator shaft 30 in an proximal direction relative to the outer sleeve member 34 to force the proximal wedge member 68 and distal wedge member 80 against the proximal and distal surfaces 18, 20, 70, 72 of upper and lower body portions 14, 16 of the intervertebral implant 10 to separate the upper and lower body portions 14, 16 to cause the intervertebral implant 10 to expand intermediate the vertebral bodies. The method can be accomplished utilizing the various embodiments as described herein.


For any of the embodiments disclosed above, installation can be simplified through the use of the installation equipment. The installation equipment can comprise a pistol grip or plier-type grip so that the clinician can, for example, position the equipment at the proximal extension of actuator shaft 30, against the proximal end 42 of the outer sleeve member 34, and through one or more contractions with the hand, the proximal end 42 of the outer sleeve member 34 and the distal end 36 of the inner member 32 can be drawn together to appropriately tension.


In particular, while proximal traction is applied to the proximal end 38 of the inner member 32, appropriate tensioning of the actuator shaft 30 is accomplished by tactile feedback or through the use of a calibration device for applying a predetermined load on the actuator shaft 30. Following appropriate tensioning of the actuator shaft 30, the proximal extension of the actuator shaft 30 (or the tool 50) is preferably removed, such as by being unscrewed, cut off or snapped off. Such a cut can be made using conventional saws, cutters or bone forceps which are routinely available in the clinical setting.


In certain embodiments, the proximal extension of the actuator shaft 30 may be removed by cauterizing. Cauterizing the proximal extension may advantageously fuse the proximal end 38 of the inner member 32 to the distal end 42 of the outer sleeve member 34, thereby adding to the retention force between the outer sleeve member 34 and the inner member 30 and between the proximal and distal protrusions 68, 80 and the respective ones of the distal and proximal surfaces 18, 20 and 70, 72, if applicable. Such fusion between the proximal end 38 of the inner member 32 to the distal end 42 of the outer sleeve member 34 may be particularly advantageous if the intervertebral implant 10 is made from a bioabsorbable and/or biodegradable material. In this manner, as the material of the proximal anchor and/or the actuator shaft is absorbed or degrades, the fusion caused by the cauterizing continues to provide retention force between the proximal anchor and the pin.


Following trimming the proximal end of actuator shaft 30, the access site may be closed and dressed in accordance with conventional wound closure techniques.


Preferably, the clinician will have access to an array of intervertebral implants 10, having different widths and axial lengths. These may be packaged one or more per package in sterile envelopes or peelable pouches. Upon encountering an intervertebral space for which the use of a intervertebral implant 10 is deemed appropriate, the clinician will assess the dimensions and load requirements of the spine 12, and select an intervertebral implant 10 from the array which meets the desired specifications.


The embodiments described above may be used in other anatomical settings beside the spine. As mentioned above, the embodiments described herein may be used for spinal fixation. In embodiments optimized for spinal fixation in an adult human population, the upper and lower portions 14, 15 will generally be within the range of from about 10-60 mm in length and within the range of from about 5-30 mm in maximum width and the device can expand from a height of about 5 mm to about 30 mm.


For the embodiments discussed herein, the intervertebral implant components can be manufactured in accordance with any of a variety of techniques which are well known in the art, using any of a variety of medical-grade construction materials. For example, the upper and lower body portions 14, 16, the actuator shaft 30, and other components can be injection-molded from a variety of medical-grade polymers including high or other density polyethylene, PEEK™ polymers, nylon and polypropylene. Retention structures 40, 44 can also be integrally molded with the actuator shaft 30. Alternatively, retention structures 40, 44 can be machined or pressed into the actuator shaft 30 in a post-molding operation, or secured using other techniques depending upon the particular design. The retention structures 40, 44 can also be made of a different material.


The intervertebral implant 10 components can be molded, formed or machined from biocompatible metals such as Nitinol, stainless steel, titanium, and others known in the art. Non-metal materials such as plastics, PEEK™ polymers, and rubbers can also be used. Further, the implant components can be made of combinations of PEEK™ polymers and metals. In one embodiment, the intervertebral implant components can be injection-molded from a bioabsorbable material, to eliminate the need for a post-healing removal step.


The intervertebral implant components may contain one or more bioactive substances, such as antibiotics, chemotherapeutic substances, angiogenic growth factors, substances for accelerating the healing of the wound, growth hormones, antithrombogenic agents, bone growth accelerators or agents, and the like. Such bioactive implants may be desirable because they contribute to the healing of the injury in addition to providing mechanical support.


In addition, the intervertebral implant components may be provided with any of a variety of structural modifications to accomplish various objectives, such as osteoincorporation, or more rapid or uniform absorption into the body. For example, osteoincorporation may be enhanced by providing a micropitted or otherwise textured surface on the intervertebral implant components. Alternatively, capillary pathways may be provided throughout the intervertebral implant, such as by manufacturing the intervertebral implant components from an open cell foam material, which produces tortuous pathways through the device. This construction increases the surface area of the device which is exposed to body fluids, thereby generally increasing the absorption rate. Capillary pathways may alternatively be provided by laser drilling or other technique, which will be understood by those of skill in the art in view of the disclosure herein. Additionally, apertures can be provided in the implant to facilitate packing of biologics into the implant, backfilling, and/or osseointegration of the implant. In general, the extent to which the intervertebral implant can be permeated by capillary pathways or open cell foam passageways may be determined by balancing the desired structural integrity of the device with the desired reabsorption time, taking into account the particular strength and absorption characteristics of the desired polymer.


The intervertebral implant may be sterilized by any of the well known sterilization techniques, depending on the type of material. Suitable sterilization techniques include heat sterilization, radiation sterilization, such as cobalt irradiation or electron beams, ethylene oxide sterilization, and the like.


Referring now to FIGS. 14A-14D, various modified configurations and applications of the implant are illustrated. As mentioned above, the embodiments, applications, and arrangements disclosed herein can be readily modified by one of skill in order to suit the requirements of the clinician. It will therefore be appreciated that embodiments disclosed herein are not limited to those illustrated, but can be combined and/or modified.



FIG. 14A is a side view of another embodiment of an intervertebral implant 10 wherein the upper and lower body portions 14, 16 have generally slanted configurations. As illustrated, the upper and lower body portions 14, 16 can define generally convex upper and lower surfaces 140, 142, respectively. Such an embodiment can be beneficial especially in applications where the implant 10 must complement the natural curvature of the spine. The upper and lower surfaces 140, 142 can generally match the concavity of adjacent upper and lower vertebral bodies. It will be appreciated that the slanted configuration can be modified and a range of curvatures can be accommodated as required. Furthermore, the upper and lower surfaces 140, 142 can be generally planar and oriented at an angle relative to each other. In some embodiments, the upper and lower surfaces 140, 142 of the implant 10 can be formed such that the implant defines a generally wedge-shaped design. The dimensions of the implant 10 can be varied as desired.


As illustrated in FIG. 14A, the upper and lower body portions 14, 16 can be configured such that exterior surfaces thereof are oriented obliquely with respect to interior surfaces thereof. For example, in some embodiments, the upper and lower body portions 14, 16 can be configured generally as wedges. However, as also mentioned with regard to FIGS. 12 and 13, it is also contemplated that the actuation mechanism of the implant can allow the spacing between the proximal ends of the respective ones of the upper and lower body portions to be different from of the spacing between the distal ends thereof due to the overall configuration of the implant.


In this regard, the angular relationship between the upper and lower body portions 14, 16 can be varied as desired. For example, the spacing of the distal ends of the upper and lower body portions 14, 16 can increase at a greater rate as the implant is expanded that the spacing between the proximal ends of the upper and lower body portions 14, 16, or vice versa. This feature can result from the interaction of the actuator shaft with the implant, the wedges with the upper and lower body portions 14, 16, or the actuator shaft with the wedges. It is contemplated, for example, that the distal and proximal wedges can have different configurations with different angular relationships between their contact surfaces. Further, the actuator shaft can have different thread configurations such that one wedge advances faster than the other wedge upon rotation of the pin. Alternative embodiments can also be developed based on the present disclosure.


Referring now to FIG. 14B, a top view of another embodiment of an intervertebral implant 10 is provided wherein the implant 10 has a generally clamshell configuration. Such an embodiment can be beneficial in applications where the clinician desires to support the vertebrae principally about their peripheral aspects.


For example, at least one of the upper and lower body portions 14, 16 can be configured to have a semicircular face. When such an embodiment is implanted and deployed in a patient, the outwardly bowed portions of the upper and lower body portions 14, 16 provide a footprint that allows the implant 10 to contact the vertebrae about their periphery, as opposed to merely supporting the vertebrae in a substantially central or axial location. In such embodiments, the upper and lower body portions 14, 16 can thus be banana or crescent shaped to facilitate contact with cortical bone. Thus, such embodiments can employ the more durable, harder structure of the periphery of the vertebrae to support the spine.


In an additional embodiment, FIG. 14C shows a top view of an intervertebral implant 10 illustrating that the implant 10 can have a generally square configuration and footprint when implanted into the intervertebral space of the spine 12. Such a configuration would likely be utilized in a more invasive procedure, rather than in percutaneous applications. As mentioned above with respect to FIG. 14B, the footprint of such an embodiment can allow the implant 10 to more fully contact the more durable, harder portions of the vertebrae to facilitate support and healing of the spine. Alternative embodiments can be created that provide ovular, circular, hexagonal, rectangular, and any other shaped footprint.


Furthermore, FIG. 14D is a top view of the spine 12 illustrating an exemplary application of the intervertebral implant. In this example, a plurality of intervertebral implants 10′ and 10″ (shown in hidden lines) can be disposed in an intervertebral space of the spine 12 to support adjacent vertebrae. As mentioned above, one of the beneficial aspects of embodiments of the implant provides that the implant can be used in percutaneous applications.


In FIG. 14D, it is illustrated that one or more implants 10′ can be implanted and oriented substantially parallel with respect to each other in order to support the adjacent vertebrae. Also shown, at least two implants 10″ can be implanted and oriented transversely with respect to each other in order to support the adjacent vertebrae. In addition, it is contemplated that a cross-midline approach can be used wherein a single implant is placed into the intervertebral space in an orientation as depicted for one of the implants 10′, although more centrally. Thus, the angular orientation of the implant(s) can be varied. Further, the number of implants used in the spinal fusion procedure can also be varied to include one or more. Other such configurations, orientations, and operational parameters are contemplated in order to aid the clinician in ensuring that the adjacent vertebrae are properly supported, and that such procedure is performed in a minimally invasive manner.


Referring now to FIG. 15, yet another embodiment is provided. FIG. 15 is a side view of an intervertebral implant 10 in an unexpanded state in which a screw mechanism 150 can be utilized to draw the proximal and distal wedged members 68, 80 together to cause the implant to move to an expanded state. Thus, a rotational motion, instead of a translational motion (as discussed above in reference to other embodiments) can be utilized to cause the implant 10 to move to its expanded state.


In some embodiments, the screw mechanism 150 can comprise an Archimedes screw, a jack bolt, or other fastener that can cause the convergence of two elements that are axially coupled to the fastener. The screw mechanism 150 can have at least one thread disposed along at least a portion thereof, if not along the entire length thereof. Further, the screw mechanism can be threadably attached to one or both of the proximal and distal wedge members 68, 80. As illustrated in FIG. 15, the distal wedge member 80 can also be freely rotatably attached to the screw mechanism 150 while the proximal wedge member 68 is threadably attached thereto. Further, as disclosed above with respect to the pin, the screw mechanism 150 can also be configured such that a proximal portion of the screw mechanism 150 can be removed after the implant 10 has been expanded in order to eliminate any proximal protrusion of the screw mechanism 150.


Therefore, in the illustrated embodiment, it is contemplated that upon rotation of the screw mechanism 150, the proximal and distal wedged members 68, 80 can be axially drawn closer together. As a result of this axial translation, the proximal and distal wedged members 68, 80 can contact the respective ones of the proximal and distal surfaces 18, 20 and 70, 72 in order to facilitate separation of the upper and lower body portions 14, 16, as similarly disclosed above.


The screw mechanism 150 can be utilized to provide a stabilizing axial force to the proximal and distal wedge members 68, 80 in order to maintain the expansion of the implant 10. However, it is also contemplated that other features can be incorporated into such an embodiment to facilitate the maintenance of the expansion. In this regard, although the axial force provided by the screw mechanism 150 can tend to maintain the position and stability of the proximal and distal wedge members 68, 80, additional features can be employed to ensure the strength and stability of the implant 10 when in its expanded state.


For example, as discussed above with respect to FIGS. 10A-10B, the proximal and distal wedge members 68, 80 can include engagement surfaces 90, 92, such as stepped contours 94, 96. As discussed above, the use of the engagement surfaces 90, 92 can permit one-way, ratchet type longitudinal movement of proximal and distal wedge members 68, 80 relative to the proximal and distal surfaces 18, 20 and 70, 72 in order to maintain the upper and lower body portions 14, 16 at a given separation distance.


Furthermore, as also disclosed above, at least one of the proximal and distal surfaces 18, 20 and 70, 72 of the upper and lower body portions 14, 16 can include complimentary engagement surfaces 100, 102, 104, 106 to enhance the engagement between the respective ones of the distal and proximal protrusions 68, 80. In an embodiment, the complimentary engagement surfaces 100, 102, 104, 106 can be configured as stepped contours 108, 110 and 112, 114. Thus, the stepped contours 108, 110, 112, 114 can engage the stepped contours 94, 96 of the wedge members 68, 80 to permit one-way ratcheting of the proximal and distal wedge members 68, 80 along the proximal and distal surfaces 18, 20, 70, 72.


Therefore, some embodiments can be configured such that a rotational motion can be exerted on the actuator shaft or screw mechanism, instead of a pulling or translational motion, in order to expand an embodiment of the implant from an unexpanded state (such as that illustrated in FIG. 12) to an expanded state (such as that illustrated in FIG. 13). Such embodiments can be advantageous in certain clinical conditions and can provide the clinician with a variety of options for the benefit of the patient. Further, the various advantageous features discussed herein with respect to other embodiments can also be incorporated into such embodiments.


Referring now to FIG. 16A-19, another embodiment of the implant is illustrated. FIG. 16A is a perspective view of an intervertebral implant 200 in an unexpanded state. The implant 200 can comprise upper and lower body portions 202, 204, proximal and distal wedge members 206, 208, and an actuator shaft 210. In the unexpanded state, the upper and lower body portions 202, 204 can be generally abutting with a height of the implant 200 being minimized. However, the implant 200 can be expanded, as shown in FIG. 16B to increase the height of the implant 200 when implanted into the intervertebral space of the spine.


In some embodiments, the height of the implant 200 can be between approximately 7-15 mm, and more preferably, between approximately 8-13 mm. The width of the implant can be between approximately 7-11 mm, and preferably approximately 9 mm. The length of the implant 200 can be between approximately 18-30 mm, and preferably approximately 22 mm. Thus, the implant 200 can have a preferred aspect ratio of between approximately 7:11 and 15:7, and preferably approximately between 8:9 and 13:9. It is contemplated that various modifications to the dimension disclosed herein can be made by one of skill and the mentioned dimensions shall not be construed as limiting.


Additionally, as noted above, the implant 200 can also be made using non-metal materials such as plastics, PEEK™ polymers, and rubbers. Further, the implant components can be made of combinations of PEEK™ polymers and metals. Accordingly, the implant 200 can be at least partially radiolucent, which radiolucency can allow a doctor to perceive the degree of bone growth around and through the implant. The individual components of the implant 200 can be fabricated of such materials based on needed structural, biological and optical properties.


As discussed generally above with respect to FIG. 15, it is contemplated that the actuator shaft 210 can be rotated to cause the proximal and distal wedge members to move toward each other, thus causing the upper and lower body portions 202, 204 to be separated. Although, the present embodiment is illustrated using this mode of expansion, it is contemplated that other modes of expansion described above (e.g., one way-ratchet type mechanism) can be combined with or interchanged herewith.


In some embodiments, the implant 200 can be configured such that the proximal and distal wedge members 206, 208 are interlinked with the upper and lower body portions 202, 204 to improve the stability and alignment of the implant 200. For example, the upper and lower body portions 202, 204 can be configured to include slots (slot 220 is shown in FIG. 16A, and slots 220, 222 are shown in FIG. 16B; the configuration of such an embodiment of the upper and lower body portions 202, 204 is also shown in FIGS. 20A-21B, discussed below). In such an embodiment, the proximal and distal wedge members 206, 208 can be configured to include at least one guide member (an upper guide member 230 of the proximal wedge member 206 is shown in FIG. 16A and an upper guide member 232 of the distal wedge member 208 is shown in FIG. 18) that at least partially extends into a respective slot of the upper and lower body portions. The arrangement of the slots and the guide members can enhance the structural stability and alignment of the implant 200.


In addition, it is contemplated that some embodiments of the implant 200 can be configured such that the upper and lower body portions 202, 204 each include side portions (shown as upper side portion 240 of the upper body portion 202 and lower side portion 242 of the lower body portion 204) that project therefrom and facilitate the alignment, interconnection, and stability of the components of the implant 200. FIG. 16B is a perspective view of the implant 200 wherein the implant 200 is in the expanded state. The upper and lower side portions 240, 242 can be configured to have complementary structures that enable the upper and lower body portions 202, 204 to move in a vertical direction. Further, the complementary structures can ensure that the proximal ends of the upper and lower body portions 202, 204 generally maintain spacing equal to that of the distal ends of the upper and lower body portions 202, 204. The complementary structures are discussed further below with regard to FIGS. 17-21B.


Furthermore, as described further below, the complementary structures can also include motion limiting portions that prevent expansion of the implant beyond a certain height. This feature can also tend to ensure that the implant is stable and does not disassemble during use.


In some embodiments, the actuator shaft 210 can facilitate expansion of the implant 200 through rotation, longitudinal contract of the pin, or other mechanisms. The actuator shaft 210 can include threads that threadably engage at least one of the proximal and distal wedge members 206, 208. The actuator shaft 210 can also facilitate expansion through longitudinal contraction of the actuator shaft as proximal and distal collars disposed on inner and outer sleeves move closer to each other to in turn move the proximal and distal wedge members closer together, as described above with respect to actuator shaft 30 shown in FIGS. 5-6. It is contemplated that in other embodiments, at least a portion of the actuator shaft can be axially fixed relative to one of the proximal and distal wedge members 206, 208 with the actuator shaft being operative to move the other one of the proximal and distal wedge members 206, 208 via rotational movement or longitudinal contraction of the pin.


Further, in embodiments wherein the actuator shaft 210 is threaded, it is contemplated that the actuator shaft 210 can be configured to bring the proximal and distal wedge members closer together at different rates. In such embodiments, the implant 200 could be expanded to a V-configuration or wedged shape. For example, the actuator shaft 210 can comprise a variable pitch thread that causes longitudinal advancement of the distal and proximal wedge members at different rates. The advancement of one of the wedge members at a faster rate than the other could cause one end of the implant to expand more rapidly and therefore have a different height that the other end. Such a configuration can be advantageous depending on the intervertebral geometry and circumstantial needs.


In other embodiments, the implant 200 can be configured to include anti-torque structures 250. The anti-torque structures 250 can interact with at least a portion of a deployment tool during deployment of the implant to ensure that the implant maintains its desired orientation (see FIGS. 25-26 and related discussion). For example, when the implant 200 is being deployed and a rotational force is exerted on the actuator shaft 210, the anti-torque structures 250 can be engaged by a non-rotating structure of the deployment tool to maintain the rotational orientation of the implant 200 while the actuator shaft 210 is rotated. The anti-torque structures 250 can comprise one or more inwardly extending holes or indentations on the proximal wedge member 206, which are shown as a pair of holes in FIGS. 16A-B. However, the anti-torque structures 250 can also comprise one or more outwardly extending structures.


According to yet other embodiments, the implant 200 can be configured to include one or more apertures 252 to facilitate osseointegration of the implant 200 within the intervertebral space. As mentioned above, the implant 200 may contain one or more bioactive substances, such as antibiotics, chemotherapeutic substances, angiogenic growth factors, substances for accelerating the healing of the wound, growth hormones, antithrombogenic agents, bone growth accelerators or agents, and the like. Indeed, various biologics can be used with the implant 200 and can be inserted into the disc space or inserted along with the implant 200. The apertures 252 can facilitate circulation and bone growth throughout the intervertebral space and through the implant 200. In such implementations, the apertures 252 can thereby allow bone growth through the implant 200 and integration of the implant 200 with the surrounding materials.



FIG. 17 is a bottom view of the implant 200 shown in FIG. 16A. As shown therein, the implant 200 can comprise one or more protrusions 260 on a bottom surface 262 of the lower body portion 204. Although not shown in this FIG., the upper body portion 204 can also define a top surface having one or more protrusions thereon. The protrusions 260 can allow the implant 200 to engage the adjacent vertebrae when the implant 200 is expanded to ensure that the implant 200 maintains a desired position in the intervertebral space.


The protrusions 260 can be configured in various patterns. As shown, the protrusions 260 can be formed from grooves extending widthwise along the bottom surface 262 of the implant 200 (also shown extending from a top surface 264 of the upper body portion 202 of the implant 200). The protrusions 260 can become increasingly narrow and pointed toward their apex. However, it is contemplated that the protrusions 260 can be one or more raised points, cross-wise ridges, or the like.



FIG. 17 also illustrates a bottom view of the profile of an embodiment of the upper side portion 240 and the profile of the lower side portion 242. As mentioned above, the upper and lower side portions 240, 242 can each include complementary structures to facilitate the alignment, interconnection, and stability of the components of the implant 200. FIG. 17 also shows that in some embodiments, having a pair of each of upper and lower side portions 240, 242 can ensure that the upper and lower body portions 202, 204 do not translate relative to each other, thus further ensuring the stability of the implant 200.


As illustrated in FIG. 17, the upper side portion 240 can comprise a groove 266 and the lower side portion can comprise a rib 268 configured to generally mate with the groove 266. The groove 266 and rib 268 can ensure that the axial position of the upper body portion 202 is maintained generally constant relative to the lower body portion 204. Further, in this embodiment, the grooves 266 and rib 268 can also ensure that the proximal ends of the upper and lower body portions 202, 204 generally maintain spacing equal to that of the distal ends of the upper and lower body portions 202, 204. This configuration is also illustratively shown in FIG. 18.


Referring again to FIG. 17, the implant 200 is illustrated in the unexpanded state with each of the respective slots 222 of the lower body portion 204 and lower guide members 270, 272 of the respective ones of the proximal and distal wedge members 206, 208. In some embodiments, as shown in FIGS. 16A-17 and 19-21B, the slots and guide members can be configured to incorporate a generally dovetail shape. Thus, once a given guide member is slid into engagement with a slot, the guide member can only slide longitudinally within the slot and not vertically from the slot. This arrangement can ensure that the proximal and distal wedge members 206, 208 are securely engaged with the upper and lower body portions 202, 204.


Furthermore, in FIG. 18, a side view of the embodiment of the implant 200 in the expanded state illustrates the angular relationship of the proximal and distal wedge members 206, 208 and the upper and lower body portions 202, 204. As mentioned above, the dovetail shape of the slots and guide members ensures that for each given slot and guide member, a given wedge member is generally interlocked with the give slot to only provide one degree of freedom of movement of the guide member, and thus the wedge member, in the longitudinal direction of the given slot.


Accordingly, in such an embodiment, the wedge members 206, 208 may not be separable from the implant when the implant 200 is in the unexpanded state (as shown in FIG. 16A) due to the geometric constraints of the angular orientation of the slots and guide members with the actuator shaft inhibiting longitudinal relative movement of the wedge members 206, 208 relative to the upper and lower body portions 202, 204. Such a configuration ensures that the implant 200 is stable and structurally sound when in the unexpanded state or during expansion thereof, thus facilitating insertion and deployment of the implant 200.


Such an embodiment of the implant 200 can therefore be assembled by placing or engaging the wedge members 206, 208 with the actuator shaft 210, moving the wedge members 206, 208 axially together, and inserting the upper guide members 230, 232 into the slots 220 of the upper body portion 202 and the lower guide members 270, 272 into the slots 222 of the lower body portion 204. The wedge members 206, 208 can then be moved apart, which movement can cause the guide members and slots to engage and bring the upper and lower body portions toward each other. The implant 200 can then be prepared for insertion and deployment by reducing the implant 200 to the unexpanded state.


During assembly of the implant 200, the upper and lower body portions 202, 204 can be configured to snap together to limit expansion of the implant 200. For example, the upper and lower side portions 240, 242 can comprise upper and lower motion-limiting structures 280, 282, as shown in the cross-sectional view of FIG. 19. After the wedge members 206, 208 are engaged with the upper and lower body portions 202, 204 and axially separated to bring the upper and lower body portions 202, 204 together, the upper motion-limiting structure 280 can engage the lower motion-limiting structure 282. This engagement can occur due to deflection of at least one of the upper and lower side portions 240, 242. However, the motion-limiting structures 280, 282 preferably comprise interlocking lips or shoulders to engage one another when the implant 200 has reached maximum expansion. Accordingly, after the wedge members 206, 208 are assembled with the upper and lower body portions 202, 204, these components can be securely interconnected to thereby form a stable implant 200.


Referring again to FIG. 18, the implant 200 can define generally convex top and bottom surfaces 264, 262. This shape, as discussed above with respect to FIG. 14A, can be configured to generally match the concavity of adjacent vertebral bodies.



FIGS. 20A-B illustrate perspective views of the lower body portion 204 of the implant 200, according to an embodiment. These FIGS. provide additional clarity as to the configuration of the slots 222, the lower side portions 242, and the lower motion-limiting members 282 of the lower body portion 204. Similarly, FIGS. 21A-B illustrate perspective views of the upper body portion 202 of the implant 200, according to an embodiment. These FIGS. provide additional clarity as to the configuration of the slots 220, the upper side portions 240, and the upper motion-limiting members 280 of the upper body portion 202. Additionally, the upper and lower body portions 202, 204 can also define a central receptacle 290 wherein the actuator shaft can be received. Further, as mentioned above, the upper and lower body portions 202, 204 can define one or more apertures 252 to facilitate osseointegration.



FIG. 22 is a perspective view of an actuator shaft 210 of the implant 200 shown in FIG. 16A. In this embodiment, the actuator shaft 210 can be a single, continuous component having threads 294 disposed thereon for engaging the proximal and distal wedge members 206, 208. The threads can be configured to be left hand threads at a distal end of the actuator shaft 210 and right hand threads at a proximal other end of the actuator shaft for engaging the respective ones of the distal and proximal wedge members 208, 206. Accordingly, upon rotation of the actuator shaft 210, the wedge members 206, 208 can be caused to move toward or away from each other to facilitate expansion or contraction of the implant 200. Further, as noted above, although this embodiment is described and illustrated as having the actuator shaft 210 with threads 294, it is also contemplated that relative movement of the wedge members can be achieved through the use of the actuator shaft 30 described in reference to FIGS. 5-6, and that such an actuator shaft could likewise be used with the embodiment shown in FIGS. 16A-19.


In accordance with an embodiment, the actuator shaft 210 can also comprise a tool engagement section 296 and a proximal engagement section 298. The tool engagement section 296 can be configured as a to be engaged by a tool, as described further below. The tool engagement section 296 can be shaped as a polygon, such as a hex shape. As shown, the tool engagement section 296 is star shaped and includes six points, which configuration tends to facilitate the transfer of torque to the actuator shaft 210 from the tool. Other shapes and configurations can also be used.


Furthermore, the proximal engagement section 298 of the actuator shaft 210 can comprise a threaded aperture. The threaded aperture can be used to engage a portion of the tool for temporarily connecting the tool to the implant 200. It is also contemplated that the proximal engagement section 298 can also engage with the tool via a snap or press fit.



FIG. 23A-B illustrate perspective views of the proximal wedge member 206 of the implant 200. As described above, the proximal wedge member can include one or more anti-torque structures 250. Further, the guide members 230, 270 are also illustrated. The proximal wedge member 206 can comprise a central aperture 300 wherethrough an actuator shaft can be received. When actuator shaft 210 is used in an embodiment, the central aperture 300 can be threaded to correspond to the threads 294 of the actuator shaft 210. In other embodiments, the actuator shaft can engage other portions of the wedge member 206 for causing expansion or contraction thereof.



FIG. 24A-B illustrate perspective views of the distal wedge member 208 of the implant 200. As similarly discussed above with respect to the proximal wedge member 206, the guide members 232, 272 and a central aperture 302 of the proximal wedge member 206 are illustrated. The central aperture 302 can be configured to receive an actuator shaft therethrough. When actuator shaft 210 is used in an embodiment, the central aperture 302 can be threaded to correspond to the threads 294 of the actuator shaft 210. In other embodiments, the actuator shaft can engage other portions of the wedge member 208 for causing expansion or contraction thereof.


Referring now to FIG. 25, there is illustrated a perspective view of a deployment tool 400 according to another embodiment. The tool 400 can comprise a handle section 402 and a distal engagement section 404. The handle portion 402 can be configured to be held by a user and can comprise various features to facilitate implantation and deployment of the implant.


According to an embodiment, the handle section 402 can comprise a fixed portion 410, and one or more rotatable portions, such as the rotatable deployment portion 412 and the rotatable teathering portion 414. In such an embodiment, the teathering portion 414 can be used to attach the implant to the tool 400 prior to insertion and deployment. The deployment portion 412 can be used to actuate the implant and rotate the actuator shaft thereof for expanding the implant. Then, after the implant is expanded and properly placed, the teathering portion 414 can again be used to unteather or decouple the implant from the tool 400.


Further, the distal engagement section 404 can comprise a fixed portion 420, an anti-torque component 422, a teathering rod (element 424 shown in FIG. 26), and a shaft actuator rod (element 426 shown in FIG. 26) to facilitate engagement with and actuation of the implant 200. The anti-torque component 422 can be coupled to the fixed portion 420. As described above with reference to FIGS. 16A-B, in an embodiment, the implant 200 can comprise one or more anti-torque structures 250. The anti-torque component 422 can comprise one or more protrusions that engage the anti-torque structures 250 to prevent movement of the implant 200 when a rotational force is applied to the actuator shaft 210 via the tool 400. As illustrated, the anti-torque component 422 can comprise a pair of pins that extend from a distal end of the tool 400. However, it is contemplated that the implant 200 and tool 400 can be variously configured such that the anti-torque structures 250 and the anti-torque component 422 interconnect to prevent a torque being transferred to the implant 200. The generation of the rotational force will be explained in greater detail below with reference to FIG. 26, which is a side-cross sectional view of the tool 400 illustrating the interrelationship of the components of the handle section 402 and the distal engagement section 404.


For example, as illustrated in FIG. 26, the fixed portion 410 of the handle section 402 can be interconnected with the fixed portion 420 of the distal engagement section 404. The distal engagement section 404 can be configured with the deployment portion 412 being coupled with the shaft actuator rod 426 and the teathering portion 414 being coupled with the teathering rod 424. Although these portions can be coupled to each other respectively, they can move independently of each other and independently of the fixed portions. Thus, while holding the fixed portion 410 of the handle section 402, the deployment portion 412 and the teathering portion 414 can be moved to selectively expand or contract the implant or to attach the implant to the tool, respectively. In the illustrated embodiment, these portions 412, 414 can be rotated to cause rotation of an actuator shaft 210 of an implant 200 engaged with the tool 400.


As shown in FIG. 26, the teather rod 424 can comprise a distal engagement member 430 being configured to engage a proximal end of the actuator shaft 210 of the implant 200 for rotating the actuator shaft 210 to thereby expand the implant from an unexpanded state to and expanded state. The teather rod 424 can be configured with the distal engagement member 430 being a threaded distal section of the rod 424 that can be threadably coupled to an interior threaded portion of the actuator shaft 210.


In some embodiments, the tool 400 can be prepared for a single-use and can be packaged with an implant preloaded onto the tool 400. This arrangement can facilitate the use of the implant and also provide a sterile implant and tool for an operation. Thus, the tool 400 can be disposable after use in deploying the implant.


Referring again to FIG. 25, an embodiment of the tool 400 can also comprise an expansion indicator gauge 440 and a reset button 450. The expansion indicator gauge 440 can be configured to provide a visual indication corresponding to the expansion of the implant 200. For example, the gauge 440 can illustrate an exact height of the implant 200 as it is expanded or the amount of expansion. As shown in FIG. 26, the tool 400 can comprise a centrally disposed slider element 452 that can be in threaded engagement with a thread component 454 coupled to the deployment portion 412.


In an embodiment, the slider element 452 and an internal cavity 456 of the tool can be configured such that the slider element 452 is provided only translational movement in the longitudinal direction of the tool 400. Accordingly, as the deployment portion 412 is rotated, the thread component 454 is also rotated. In such an embodiment, as the thread component 454 rotates and is in engagement with the slider component 452, the slider element 452 can be incrementally moved from an initial position within the cavity 456 in response to the rotation of the deployment portion 412. An indicator 458 can thus be longitudinally moved and viewed to allow the gauge 440 to visually indicate the expansion and/or height of the implant 200. In such an embodiment, the gauge 440 can comprises a transparent window through which the indicator 458 on the slider element 452 can be seen. In the illustrated embodiment, the indicator 458 can be a marking on an exterior surface of the slider element 452.


In embodiments where the tool 400 can be reused, the reset button 450 can be utilized to zero out the gauge 440 to a pre-expansion setting. In such an embodiment, the slider element 452 can be spring-loaded, as shown with the spring 460 in FIG. 26. The reset button 450 can disengage the slider element 452 and the thread component 454 to allow the slider element 452 to be forced back to the initial position.


The specific dimensions of any of the embodiment disclosed herein can be readily varied depending upon the intended application, as will be apparent to those of skill in the art in view of the disclosure herein. Moreover, although the present inventions have been described in terms of certain preferred embodiments, other embodiments of the inventions including variations in the number of parts, dimensions, configuration and materials will be apparent to those of skill in the art in view of the disclosure herein. In addition, all features discussed in connection with any one embodiment herein can be readily adapted for use in other embodiments herein to form various combinations and sub-combinations. The use of different terms or reference numerals for similar features in different embodiments does not imply differences other than those which may be expressly set forth. Accordingly, the present inventions are intended to be described solely by reference to the appended claims, and not limited to the preferred embodiments disclosed herein.

Claims
  • 1. A deployment tool for inserting and expanding an expandable intervertebral implant, the deployment tool comprising: a handle section;a rod that is supported so as to be rotatable relative to the handle section, the rod having a distal engagement member configured to engage an actuator shaft of the intervertebral implant, such that rotation of the rod causes the actuator shaft to rotate, thereby expanding the implant from an unexpanded state to an expanded state;first and second protrusions that extend along respective straight and linear axes that are parallel to each other, and are configured to be inserted into respective anti-torque apertures of the implant so as to stabilize the implant as the rod is rotated to cause the actuator shaft to rotate; anda slider member that is translatable relative to both the handle section and the rod, wherein the slider member does not define the first and second protrusions, andwherein the distal engagement member is disposed between the first and second protrusions.
  • 2. The deployment tool of claim 1, further comprising a sleeve that extends out with respect to the handle section, wherein the rod is disposed in the sleeve.
  • 3. The deployment tool of claim 2, wherein the sleeve extends out from the handle section.
  • 4. The deployment tool of claim 1, further comprising a teathering rod that is threaded so as to threadedly couple to the implant.
  • 5. The deployment tool of claim 1, wherein the distal engagement member and the first and second protrusions are positioned so as to be horizontally aligned with each other when the protrusions that are inserted into the respective anti-torque apertures.
  • 6. The deployment tool of claim 1, wherein the distal engagement member and the first and second protrusions are coplanar with each other.
  • 7. An intervertebral implant system comprising: the deployment tool of claim 1; andthe intervertebral implant of claim 1 having the anti-torque apertures that receive the first and second protrusions, respectively, so as to stabilize the implant as the rod is rotated to cause the actuator shaft to rotate.
  • 8. The intervertebral implant system of claim 7, wherein the implant includes upper and lower body portions configured to selectively move toward and away from each other in response to rotation of the actuator shaft in first and second directions of rotation, respectively.
  • 9. The intervertebral implant system of claim 8, wherein the rod is configured to cause the actuator to move selectively in the first and second directions of rotation.
  • 10. A deployment tool for inserting and expanding an expandable intervertebral implant, the deployment tool comprising: a handle section;a rod that extends along a rod axis that is oriented coaxially with the handle section, wherein the rod is configured to be placed in rotatable communication with an actuator shaft of the intervertebral implant, such that rotation of the rod causes the actuator shaft to rotate, thereby expanding the implant from an unexpanded state to an expanded state;first and second protrusions that extend along respective straight and linear axes that are parallel to each other, and are configured to be inserted into respective anti-torque apertures of the implant so as to stabilize the implant as the rod is rotated to cause the actuator shaft to rotate; anda slider member that is translatable relative to both the handle section and the rod, wherein the slider member does not define the first and second protrusions, andwherein the rod axis is disposed between the first and second protrusions with respect to a horizontal direction when the rod is in rotatable communication with the actuator shaft.
  • 11. The deployment tool of claim 10, further comprising a distal engagement member that is configured to attach to the implant, wherein rotation of the rod causes the distal engagement member to rotate.
  • 12. The deployment tool of claim 11, further comprising a teathering rod that is threaded so as to threadedly couple to the implant.
  • 13. The deployment tool of claim 10, further comprising a sleeve that extends out with respect to the handle section, wherein the rod is disposed in the sleeve.
  • 14. The deployment tool of claim 13, wherein the sleeve extends out from the handle section.
  • 15. The deployment tool of claim 10, wherein the first and second protrusions are positioned such that the rod axis is disposed between the first and second protrusions with respect to a horizontal direction when protrusions that are inserted into the respective anti-torque apertures.
  • 16. The deployment tool of claim 10, wherein the distal engagement member and the first and second protrusions are coplanar with each other.
  • 17. An intervertebral implant system comprising: the deployment tool of claim 10; andthe intervertebral implant of claim 10 having the anti-torque apertures that receive the first and second protrusions, respectively, so as to stabilize the implant as the rod is rotated to cause the actuator shaft to rotate.
  • 18. The intervertebral implant system of claim 17, wherein rotation of the actuator shaft causes a vertical distance between respective upper and lower body portions to increase, the distance being measured in a vertical direction perpendicular to the horizontal direction.
PRIORITY INFORMATION

The present application is a continuation application of U.S. application Ser. No. 13/845,644 filed Mar. 18, 2013, which is a continuation of U.S. application Ser. No. 13/334,526, filed Dec. 22, 2011 (now issued as U.S. Pat. No. 8,568,481), which is a continuation of U.S. application Ser. No. 11/952,900, filed Dec. 7, 2007 (now issued as U.S. Pat. No. 8,105,382), which claims the priority benefit of U.S. Provisional Application Ser. No. 60/869,088, filed Dec. 7, 2006. The entire contents of these applications are hereby incorporated by reference herein.

US Referenced Citations (2664)
Number Name Date Kind
1802560 Kerwin Apr 1931 A
1924695 Olson Aug 1933 A
1965653 Kennedy Jul 1934 A
2077804 Morrison Apr 1937 A
2115250 Bruson Apr 1938 A
2121193 Hanicke Jun 1938 A
2170111 Bruson Aug 1939 A
2173655 Neracher et al. Sep 1939 A
2229024 Bruson Jan 1941 A
2243717 Moreira May 1941 A
2381050 Hardinge Aug 1945 A
2388056 Hendricks Oct 1945 A
2485531 William et al. Oct 1949 A
2489870 Dzus Nov 1949 A
2570465 Lundholm Oct 1951 A
2677369 Knowles May 1954 A
2706701 Hans et al. Apr 1955 A
2710277 Shelanski et al. Jun 1955 A
2826532 Hosmer Mar 1958 A
2900305 Siggia Aug 1959 A
2977315 Scheib et al. Mar 1961 A
3091237 Skinner May 1963 A
3112743 Cochran et al. Dec 1963 A
3115804 Johnson Dec 1963 A
3228828 Romano Jan 1966 A
3312139 Di Cristina Apr 1967 A
3486505 Morrison Dec 1969 A
3489143 Halloran Jan 1970 A
3648294 Shahrestani Mar 1972 A
3698391 Mahony Oct 1972 A
3717655 Godefroi et al. Feb 1973 A
3760802 Fischer et al. Sep 1973 A
3800788 White Apr 1974 A
3805775 Fischer et al. Apr 1974 A
3811449 Gravlee et al. May 1974 A
3842825 Wagner Oct 1974 A
3848601 Ma et al. Nov 1974 A
3855638 Pilliar Dec 1974 A
3867728 Stubstad et al. Feb 1975 A
3875595 Froning Apr 1975 A
3889665 Ling et al. Jun 1975 A
3964480 Froning Jun 1976 A
3986504 Avila Oct 1976 A
4013071 Rosenberg Mar 1977 A
4052988 Doddi et al. Oct 1977 A
4091806 Aginsky May 1978 A
4105034 Shalaby et al. Aug 1978 A
4130639 Shalaby et al. Dec 1978 A
4140678 Shalaby et al. Feb 1979 A
4141087 Shalaby et al. Feb 1979 A
4175555 Herbert Nov 1979 A
4205399 Jamiolkowski et al. Jun 1980 A
4236512 Aginsky Dec 1980 A
4249435 Smith et al. Feb 1981 A
4262665 Roalstad et al. Apr 1981 A
4262676 Jamshidi Apr 1981 A
4274163 Malcom et al. Jun 1981 A
4275717 Bolesky Jun 1981 A
4312337 Donohue Jan 1982 A
4312353 Shahbabian Jan 1982 A
4313434 Segal Feb 1982 A
4341206 Perrett et al. Jul 1982 A
4349921 Kuntz Sep 1982 A
4350151 Scott Sep 1982 A
4351069 Ballintyn et al. Sep 1982 A
4352883 Lim Oct 1982 A
4369790 McCarthy Jan 1983 A
4399814 Pratt et al. Aug 1983 A
4401112 Rezaian Aug 1983 A
4401433 Luther Aug 1983 A
4409974 Freedland Oct 1983 A
4440921 Allcock et al. Apr 1984 A
4449532 Storz May 1984 A
4451256 Weikl et al. May 1984 A
4456005 Lichty Jun 1984 A
4462394 Jacobs Jul 1984 A
4463753 Gustilo Aug 1984 A
4466435 Murray Aug 1984 A
4467479 Brody Aug 1984 A
4488543 Tornier Dec 1984 A
4488549 Lee et al. Dec 1984 A
4494535 Haig Jan 1985 A
4495174 Allcock et al. Jan 1985 A
4532660 Field Aug 1985 A
4537185 Stednitz Aug 1985 A
4538612 Patrick, Jr. Sep 1985 A
4542539 Rowe et al. Sep 1985 A
4545374 Jacobson Oct 1985 A
4562598 Kranz Jan 1986 A
4573448 Kambin Mar 1986 A
4595006 Burke et al. Jun 1986 A
4601710 Moll Jul 1986 A
4625722 Murray Dec 1986 A
4625725 Davison et al. Dec 1986 A
4627434 Murray Dec 1986 A
4628945 Johnson, Jr. Dec 1986 A
4629450 Suzuki et al. Dec 1986 A
4630616 Tretinyak Dec 1986 A
4632101 Freedland Dec 1986 A
4640271 Lower Feb 1987 A
4641640 Griggs Feb 1987 A
4645503 Lin et al. Feb 1987 A
4646741 Smith Mar 1987 A
4651717 Jakubczak Mar 1987 A
4653489 Tronzo Mar 1987 A
4665906 Jervis May 1987 A
4667663 Miyata May 1987 A
4686973 Frisch Aug 1987 A
4686984 Bonnet Aug 1987 A
4688561 Reese Aug 1987 A
4697584 Haynes Oct 1987 A
4706670 Andersen et al. Nov 1987 A
4714469 Kenna Dec 1987 A
4714478 Fischer Dec 1987 A
4721103 Freedland Jan 1988 A
4723544 Moore et al. Feb 1988 A
4743256 Brantigan May 1988 A
4743257 Toermaelae et al. May 1988 A
4759766 Buettner-Janz et al. Jul 1988 A
4760843 Fischer et al. Aug 1988 A
4772287 Ray et al. Sep 1988 A
4790304 Rosenberg Dec 1988 A
4790817 Luther Dec 1988 A
4796612 Reese Jan 1989 A
4802479 Haber et al. Feb 1989 A
4815909 Simons Mar 1989 A
4827917 Brumfield May 1989 A
4834069 Umeda May 1989 A
4834757 Brantigan May 1989 A
4838282 Strasser et al. Jun 1989 A
4858601 Glisson Aug 1989 A
4862891 Smith Sep 1989 A
4863476 Shepperd Sep 1989 A
4870153 Matzner et al. Sep 1989 A
4871366 Von et al. Oct 1989 A
4873976 Schreiber Oct 1989 A
4878915 Brantigan Nov 1989 A
4880622 Allcock et al. Nov 1989 A
4888022 Huebsch Dec 1989 A
4888024 Powlan Dec 1989 A
4889119 Jamiolkowski et al. Dec 1989 A
4892550 Huebsch Jan 1990 A
4896662 Noble Jan 1990 A
4898186 Ikada et al. Feb 1990 A
4898577 Badger et al. Feb 1990 A
4903692 Reese Feb 1990 A
4904261 Dove et al. Feb 1990 A
4911718 Lee et al. Mar 1990 A
4917554 Bronn Apr 1990 A
4932969 Frey et al. Jun 1990 A
4940467 Tronzo Jul 1990 A
4941466 Romano Jul 1990 A
4946378 Hirayama et al. Aug 1990 A
4959064 Engelhardt Sep 1990 A
4961740 Ray et al. Oct 1990 A
4963144 Huene Oct 1990 A
4966587 Baumgart Oct 1990 A
4968317 Toermaelae et al. Nov 1990 A
4969888 Scholten et al. Nov 1990 A
4978334 Toye et al. Dec 1990 A
4978349 Frigg Dec 1990 A
4981482 Ichikawa Jan 1991 A
4988351 Paulos et al. Jan 1991 A
4994027 Farrell Feb 1991 A
4995200 Eberhart Feb 1991 A
5002557 Hasson Mar 1991 A
5006121 Hafeli Apr 1991 A
5011484 Breard Apr 1991 A
5013315 Barrows May 1991 A
5013316 Goble et al. May 1991 A
5015247 Michelson May 1991 A
5015255 Kuslich May 1991 A
5019082 Frey et al. May 1991 A
5030233 Ducheyne Jul 1991 A
5051189 Farrah Sep 1991 A
5053035 McLaren Oct 1991 A
5055104 Ray Oct 1991 A
5059193 Kuslich Oct 1991 A
5062849 Schelhas Nov 1991 A
5071435 Fuchs et al. Dec 1991 A
5071437 Steffee Dec 1991 A
5080662 Paul Jan 1992 A
5084043 Hertzmann et al. Jan 1992 A
5092891 Kummer et al. Mar 1992 A
5098241 Aldridge et al. Mar 1992 A
5098433 Freedland Mar 1992 A
5098435 Stednitz et al. Mar 1992 A
5102413 Poddar Apr 1992 A
5108404 Scholten et al. Apr 1992 A
5114407 Burbank May 1992 A
5116336 Frigg May 1992 A
5120171 Lasner Jun 1992 A
5122130 Keller Jun 1992 A
5122133 Evans Jun 1992 A
5122141 Simpson et al. Jun 1992 A
5123926 Pisharodi Jun 1992 A
5133719 Winston Jul 1992 A
5133755 Brekke Jul 1992 A
5134477 Knauer et al. Jul 1992 A
5139486 Moss Aug 1992 A
5147366 Arroyo et al. Sep 1992 A
5158543 Lazarus Oct 1992 A
5163939 Winston Nov 1992 A
5163989 Campbell et al. Nov 1992 A
5167663 Brumfield Dec 1992 A
5167664 Hodorek Dec 1992 A
5169400 Muehling et al. Dec 1992 A
5169402 Elloy Dec 1992 A
5171278 Pisharodi Dec 1992 A
5171279 Mathews Dec 1992 A
5171280 Baumgartner Dec 1992 A
5176651 Allgood et al. Jan 1993 A
5176683 Kimsey et al. Jan 1993 A
5176692 Wilk et al. Jan 1993 A
5176697 Hasson et al. Jan 1993 A
5178501 Carstairs Jan 1993 A
5183052 Terwilliger Feb 1993 A
5183464 Dubrul et al. Feb 1993 A
5188118 Terwilliger Feb 1993 A
5192327 Brantigan Mar 1993 A
5195506 Hulfish Mar 1993 A
5201742 Hasson Apr 1993 A
5217462 Asnis et al. Jun 1993 A
5217475 Kuber Jun 1993 A
5217486 Rice et al. Jun 1993 A
5224952 Deniega et al. Jul 1993 A
5228441 Lundquist Jul 1993 A
5234431 Keller Aug 1993 A
5241972 Bonati Sep 1993 A
5242410 Melker Sep 1993 A
5242447 Borzone Sep 1993 A
5242448 Pettine et al. Sep 1993 A
5242879 Abe et al. Sep 1993 A
5246441 Ross et al. Sep 1993 A
5250049 Michael Oct 1993 A
5250061 Michelson Oct 1993 A
5257632 Turkel et al. Nov 1993 A
5263953 Bagby Nov 1993 A
5269797 Bonati et al. Dec 1993 A
5280782 Wilk Jan 1994 A
5285795 Ryan et al. Feb 1994 A
5286001 Rafeld Feb 1994 A
5290243 Chodorow et al. Mar 1994 A
5290312 Kojimoto et al. Mar 1994 A
5300074 Frigg Apr 1994 A
5303718 Krajicek Apr 1994 A
5304142 Liebl et al. Apr 1994 A
5306307 Senter et al. Apr 1994 A
5306308 Gross et al. Apr 1994 A
5306309 Wagner et al. Apr 1994 A
5306310 Siebels Apr 1994 A
5308327 Heaven et al. May 1994 A
5308352 Koutrouvelis May 1994 A
5312410 Miller et al. May 1994 A
5312417 Wilk May 1994 A
5314477 Marnay May 1994 A
5320644 Baumgartner Jun 1994 A
5322505 Krause et al. Jun 1994 A
5324261 Amundson et al. Jun 1994 A
5330429 Noguchi et al. Jul 1994 A
5331975 Bonutti Jul 1994 A
5334184 Bimman Aug 1994 A
5334204 Clewett et al. Aug 1994 A
5342365 Waldman Aug 1994 A
5342382 Brinkerhoff et al. Aug 1994 A
5344252 Kakimoto Sep 1994 A
5361752 Moll et al. Nov 1994 A
5364398 Chapman et al. Nov 1994 A
5370646 Reese et al. Dec 1994 A
5370647 Graber et al. Dec 1994 A
5370661 Branch Dec 1994 A
5370697 Baumgartner Dec 1994 A
5372660 Davidson et al. Dec 1994 A
5374267 Siegal Dec 1994 A
5382248 Jacobson et al. Jan 1995 A
5383932 Wilson et al. Jan 1995 A
5385151 Scarfone et al. Jan 1995 A
5387213 Breard et al. Feb 1995 A
5387215 Fisher Feb 1995 A
5390683 Pisharodi Feb 1995 A
5395317 Kambin Mar 1995 A
5395371 Miller et al. Mar 1995 A
5397364 Kozak et al. Mar 1995 A
5401269 Buettner-Janz et al. Mar 1995 A
5407430 Peters Apr 1995 A
5410016 Hubbell et al. Apr 1995 A
5415661 Holmes May 1995 A
5423816 Lin Jun 1995 A
5423817 Lin Jun 1995 A
5423850 Berger Jun 1995 A
5424773 Saito Jun 1995 A
5425773 Boyd et al. Jun 1995 A
5431658 Moskovich Jul 1995 A
5441538 Bonutti Aug 1995 A
5443514 Steffee Aug 1995 A
5449359 Groiso Sep 1995 A
5449361 Preissman Sep 1995 A
5452748 Simmons et al. Sep 1995 A
5454365 Bonutti Oct 1995 A
5454790 Dubrul Oct 1995 A
5454815 Geisser et al. Oct 1995 A
5454827 Aust et al. Oct 1995 A
5456686 Klapper et al. Oct 1995 A
5458641 Ramirez Jimenez Oct 1995 A
5458643 Oka et al. Oct 1995 A
5462563 Shearer et al. Oct 1995 A
5464427 Curtis et al. Nov 1995 A
5464929 Bezwada et al. Nov 1995 A
5468245 Vargas, III Nov 1995 A
5470333 Ray Nov 1995 A
5472426 Bonati et al. Dec 1995 A
5474539 Costa et al. Dec 1995 A
5480400 Berger Jan 1996 A
5484437 Michelson Jan 1996 A
5486190 Green Jan 1996 A
5496318 Howland et al. Mar 1996 A
5498265 Asnis et al. Mar 1996 A
5501695 Anspach et al. Mar 1996 A
5505710 Dorsey, III Apr 1996 A
5507816 Bullivant Apr 1996 A
5509923 Middleman et al. Apr 1996 A
5512037 Russell et al. Apr 1996 A
5514143 Bonutti et al. May 1996 A
5514153 Bonutti May 1996 A
5514180 Heggeness et al. May 1996 A
5520690 Errico et al. May 1996 A
5520896 De et al. May 1996 A
5522398 Goldenberg et al. Jun 1996 A
5522790 Moll et al. Jun 1996 A
5522846 Bonutti Jun 1996 A
5522895 Mikos Jun 1996 A
5522899 Michelson Jun 1996 A
5527312 Ray Jun 1996 A
5527343 Bonutti Jun 1996 A
5527624 Higgins et al. Jun 1996 A
5531856 Moll et al. Jul 1996 A
5534023 Henley Jul 1996 A
5534029 Shima Jul 1996 A
5534030 Navarro et al. Jul 1996 A
5536127 Pennig Jul 1996 A
5538009 Byrne et al. Jul 1996 A
5540688 Navas Jul 1996 A
5540693 Fisher Jul 1996 A
5540711 Kieturakis et al. Jul 1996 A
5545164 Howland Aug 1996 A
5545222 Bonutti Aug 1996 A
5549610 Russell et al. Aug 1996 A
5549679 Kuslich Aug 1996 A
5554191 Lahille et al. Sep 1996 A
5556431 Buttner-Janz Sep 1996 A
5558674 Heggeness et al. Sep 1996 A
D374287 Goble et al. Oct 1996 S
5562736 Ray et al. Oct 1996 A
5562738 Boyd et al. Oct 1996 A
5564926 Braanemark Oct 1996 A
5569248 Mathews Oct 1996 A
5569251 Baker et al. Oct 1996 A
5569290 McAfee Oct 1996 A
5569548 Koike et al. Oct 1996 A
5571109 Bertagnoli Nov 1996 A
5571189 Kuslich Nov 1996 A
5571190 Ulrich et al. Nov 1996 A
5575790 Chen et al. Nov 1996 A
5591168 Judet et al. Jan 1997 A
5593409 Michelson Jan 1997 A
5595751 Bezwada et al. Jan 1997 A
5597579 Bezwada et al. Jan 1997 A
5601556 Pisharodi Feb 1997 A
5601561 Terry et al. Feb 1997 A
5601572 Middleman et al. Feb 1997 A
5607687 Bezwada et al. Mar 1997 A
5609634 Voydeville Mar 1997 A
5609635 Michelson Mar 1997 A
5613950 Yoon Mar 1997 A
5618142 Sonden et al. Apr 1997 A
5618314 Harwin et al. Apr 1997 A
5618552 Bezwada et al. Apr 1997 A
5620698 Bezwada et al. Apr 1997 A
5624447 Myers Apr 1997 A
5626613 Schmieding May 1997 A
5628751 Sander et al. May 1997 A
5628752 Asnis et al. May 1997 A
5632746 Middleman et al. May 1997 A
5639276 Weinstock et al. Jun 1997 A
5643320 Lower et al. Jul 1997 A
5645589 Li Jul 1997 A
5645596 Kim et al. Jul 1997 A
5645597 Krapiva Jul 1997 A
5645599 Samani Jul 1997 A
5645850 Bezwada et al. Jul 1997 A
5647857 Anderson et al. Jul 1997 A
5648088 Bezwada et al. Jul 1997 A
5649931 Bryant et al. Jul 1997 A
5653763 Errico et al. Aug 1997 A
5658335 Allen Aug 1997 A
5662683 Kay Sep 1997 A
5665095 Jacobson et al. Sep 1997 A
5665122 Kambin Sep 1997 A
5667508 Errico et al. Sep 1997 A
5669915 Caspar et al. Sep 1997 A
5669926 Aust et al. Sep 1997 A
5674294 Bainville et al. Oct 1997 A
5674295 Ray et al. Oct 1997 A
5674296 Bryan et al. Oct 1997 A
5676701 Yuan et al. Oct 1997 A
5679723 Cooper et al. Oct 1997 A
5681263 Flesch Oct 1997 A
5683465 Shinn et al. Nov 1997 A
5693100 Pisharodi Dec 1997 A
5695513 Johnson et al. Dec 1997 A
5697977 Pisharodi Dec 1997 A
5698213 Jamiolkowski et al. Dec 1997 A
5700239 Yoon Dec 1997 A
5700583 Jamiolkowski et al. Dec 1997 A
5702391 Lin Dec 1997 A
5702449 McKay Dec 1997 A
5702450 Bisserie Dec 1997 A
5702453 Rabbe et al. Dec 1997 A
5702454 Baumgartner Dec 1997 A
5707359 Bufalini Jan 1998 A
5713870 Yoon Feb 1998 A
5713903 Sander et al. Feb 1998 A
5716415 Steffee Feb 1998 A
5716416 Lin Feb 1998 A
5720753 Sander et al. Feb 1998 A
5725531 Shapiro Mar 1998 A
5725541 Anspach et al. Mar 1998 A
5725588 Errico et al. Mar 1998 A
5728097 Mathews Mar 1998 A
5728116 Rosenman Mar 1998 A
5735853 Olerud Apr 1998 A
5741253 Michelson Apr 1998 A
5741282 Anspach et al. Apr 1998 A
5743881 Demco Apr 1998 A
5743912 Lahille et al. Apr 1998 A
5743914 Skiba Apr 1998 A
5749879 Middleman et al. May 1998 A
5749889 Bacich et al. May 1998 A
5752969 Cunci et al. May 1998 A
5755797 Baumgartner May 1998 A
5755798 Papavero et al. May 1998 A
5756127 Grisoni et al. May 1998 A
5762500 Lazarof Jun 1998 A
5762629 Kambin Jun 1998 A
5766252 Henry et al. Jun 1998 A
5772661 Michelson Jun 1998 A
5772662 Chapman et al. Jun 1998 A
5772678 Thomason et al. Jun 1998 A
5776156 Shikhman Jul 1998 A
5782800 Yoon Jul 1998 A
5782832 Larsen et al. Jul 1998 A
5782865 Grotz Jul 1998 A
5788703 Mittelmeier et al. Aug 1998 A
5792044 Foley et al. Aug 1998 A
5797909 Michelson Aug 1998 A
5800549 Bao et al. Sep 1998 A
5807275 Jamshidi Sep 1998 A
5807327 Green et al. Sep 1998 A
5810721 Mueller et al. Sep 1998 A
5810821 Vandewalle Sep 1998 A
5810866 Yoon Sep 1998 A
5814084 Grivas et al. Sep 1998 A
5820628 Middleman et al. Oct 1998 A
5823979 Mezo Oct 1998 A
5824084 Muschler Oct 1998 A
5824093 Ray et al. Oct 1998 A
5824094 Serhan et al. Oct 1998 A
5827289 Reiley et al. Oct 1998 A
5833657 Reinhardt et al. Nov 1998 A
5836948 Zucherman et al. Nov 1998 A
5837752 Shastri et al. Nov 1998 A
5846259 Berthiaume Dec 1998 A
5848986 Lundquist et al. Dec 1998 A
5849004 Bramlet Dec 1998 A
5851212 Zirps et al. Dec 1998 A
5851216 Allen Dec 1998 A
5857995 Thomas et al. Jan 1999 A
5859150 Jamiolkowski et al. Jan 1999 A
5860973 Michelson Jan 1999 A
5860977 Zucherman et al. Jan 1999 A
5865846 Bryan et al. Feb 1999 A
5865848 Baker Feb 1999 A
5871485 Rao et al. Feb 1999 A
5873854 Wolvek Feb 1999 A
5876404 Zucherman et al. Mar 1999 A
5888220 Felt et al. Mar 1999 A
5888221 Gelbard Mar 1999 A
5888223 Bray, Jr. Mar 1999 A
5888224 Beckers et al. Mar 1999 A
5888226 Rogozinski Mar 1999 A
5888227 Cottle Mar 1999 A
5888228 Knothe et al. Mar 1999 A
5893850 Cachia Apr 1999 A
5893889 Harrington Apr 1999 A
5893890 Pisharodi Apr 1999 A
5895428 Berry Apr 1999 A
5902231 Foley et al. May 1999 A
5904690 Middleman et al. May 1999 A
5904696 Rosenman May 1999 A
5908422 Bresina Jun 1999 A
5916228 Ripich et al. Jun 1999 A
5916267 Tienboon Jun 1999 A
5919235 Husson et al. Jul 1999 A
5925056 Thomas et al. Jul 1999 A
5925074 Gingras et al. Jul 1999 A
5928235 Friedl Jul 1999 A
5928244 Tovey et al. Jul 1999 A
5931870 Cuckler et al. Aug 1999 A
5935129 McDevitt et al. Aug 1999 A
5947999 Groiso Sep 1999 A
5948000 Larsen et al. Sep 1999 A
5954635 Foley et al. Sep 1999 A
5954722 Bono Sep 1999 A
5954747 Clark Sep 1999 A
5957902 Teves Sep 1999 A
5957924 Toermaelae et al. Sep 1999 A
5961554 Janson et al. Oct 1999 A
5964730 Williams et al. Oct 1999 A
5964761 Kambin Oct 1999 A
5967783 Ura Oct 1999 A
5967970 Cowan et al. Oct 1999 A
5968044 Nicholson et al. Oct 1999 A
5968098 Winslow Oct 1999 A
5972015 Scribner et al. Oct 1999 A
5972385 Liu et al. Oct 1999 A
5976139 Bramlet Nov 1999 A
5976146 Ogawa et al. Nov 1999 A
5976186 Bao et al. Nov 1999 A
5976187 Richelsoph Nov 1999 A
5980522 Koros et al. Nov 1999 A
5984927 Wenstrom et al. Nov 1999 A
5984966 Kiema et al. Nov 1999 A
5985307 Hanson et al. Nov 1999 A
5989255 Pepper et al. Nov 1999 A
5989291 Ralph et al. Nov 1999 A
5993459 Larsen et al. Nov 1999 A
5997510 Schwemberger Dec 1999 A
5997538 Asnis et al. Dec 1999 A
5997541 Schenk Dec 1999 A
6001100 Sherman et al. Dec 1999 A
6001101 Augagneur et al. Dec 1999 A
6004327 Asnis et al. Dec 1999 A
6005161 Brekke Dec 1999 A
6007519 Rosselli Dec 1999 A
6007566 Wenstrom, Jr. Dec 1999 A
6007580 Lehto et al. Dec 1999 A
6010508 Bradley Jan 2000 A
6010513 Toermaelae et al. Jan 2000 A
6012494 Balazs Jan 2000 A
6015410 Toermaelae et al. Jan 2000 A
6015436 Schoenhoeffer Jan 2000 A
6019762 Cole Feb 2000 A
6019792 Cauthen Feb 2000 A
6019793 Perren et al. Feb 2000 A
6022350 Ganem Feb 2000 A
6022352 Vandewalle Feb 2000 A
6030162 Huebner Feb 2000 A
6030364 Durgin et al. Feb 2000 A
6030401 Marino Feb 2000 A
6033406 Mathews Mar 2000 A
6033412 Losken et al. Mar 2000 A
6036701 Rosenman Mar 2000 A
6039740 Olerud Mar 2000 A
6039761 Li et al. Mar 2000 A
6039763 Shelokov Mar 2000 A
6045552 Zucherman et al. Apr 2000 A
6045579 Hochschuler et al. Apr 2000 A
6048309 Flom et al. Apr 2000 A
6048342 Zucherman et al. Apr 2000 A
6048346 Reiley et al. Apr 2000 A
6048360 Khosravi et al. Apr 2000 A
6049026 Muschler Apr 2000 A
6053922 Krause et al. Apr 2000 A
6053935 Brenneman et al. Apr 2000 A
6056763 Parsons May 2000 A
6063121 Xavier et al. May 2000 A
6066142 Serbousek et al. May 2000 A
6066154 Reiley et al. May 2000 A
6066175 Henderson et al. May 2000 A
6068630 Zucherman et al. May 2000 A
6068648 Cole et al. May 2000 A
6071982 Wise et al. Jun 2000 A
6073051 Sharkey et al. Jun 2000 A
6074390 Zucherman et al. Jun 2000 A
6080155 Michelson Jun 2000 A
6080158 Lin Jun 2000 A
6080193 Hochschuler et al. Jun 2000 A
6083225 Winslow et al. Jul 2000 A
6083244 Lubbers et al. Jul 2000 A
6090112 Zucherman et al. Jul 2000 A
6090143 Meriwether et al. Jul 2000 A
6096038 Michelson Aug 2000 A
6096080 Nicholson et al. Aug 2000 A
6099531 Bonutti Aug 2000 A
6102914 Bulstra et al. Aug 2000 A
6102950 Vaccaro Aug 2000 A
6106557 Robioneck et al. Aug 2000 A
6110210 Norton et al. Aug 2000 A
6113624 Bezwada et al. Sep 2000 A
6113637 Gill et al. Sep 2000 A
6113638 Williams et al. Sep 2000 A
6113640 Toermaelae et al. Sep 2000 A
6117174 Nolan Sep 2000 A
6119044 Kuzma Sep 2000 A
6120508 Gruenig et al. Sep 2000 A
6123705 Michelson Sep 2000 A
6123711 Winters Sep 2000 A
6126660 Dietz Oct 2000 A
6126661 Faccioli et al. Oct 2000 A
6126663 Hair Oct 2000 A
6126686 Badylak et al. Oct 2000 A
6126689 Brett Oct 2000 A
6127597 Beyar et al. Oct 2000 A
6129762 Li Oct 2000 A
6129763 Chauvin et al. Oct 2000 A
6132435 Young Oct 2000 A
6136031 Middleton Oct 2000 A
6139558 Wagner Oct 2000 A
6139579 Steffee et al. Oct 2000 A
6146384 Lee et al. Nov 2000 A
6146387 Trott et al. Nov 2000 A
6146420 McKay Nov 2000 A
6146421 Gordon et al. Nov 2000 A
6147135 Yuan et al. Nov 2000 A
6149652 Zucherman et al. Nov 2000 A
6152926 Zucherman et al. Nov 2000 A
6156038 Zucherman et al. Dec 2000 A
6159179 Simonson Dec 2000 A
6159211 Boriani et al. Dec 2000 A
6159244 Suddaby Dec 2000 A
6161350 Espinosa Dec 2000 A
6162234 Freedland et al. Dec 2000 A
6162236 Osada Dec 2000 A
6162252 Kuras et al. Dec 2000 A
6165218 Husson et al. Dec 2000 A
6165486 Marra et al. Dec 2000 A
6168595 Durham et al. Jan 2001 B1
6168597 Biedermann et al. Jan 2001 B1
6171610 Vacanti et al. Jan 2001 B1
6174337 Keenan Jan 2001 B1
6175758 Kambin Jan 2001 B1
6176882 Biedermann et al. Jan 2001 B1
6179794 Burras Jan 2001 B1
6179873 Zientek Jan 2001 B1
6183471 Zucherman et al. Feb 2001 B1
6183472 Lutz Feb 2001 B1
6183474 Bramlet et al. Feb 2001 B1
6183517 Suddaby Feb 2001 B1
6187043 Ledergerber Feb 2001 B1
6187048 Milner et al. Feb 2001 B1
6190387 Zucherman et al. Feb 2001 B1
6190414 Young et al. Feb 2001 B1
6193757 Foley et al. Feb 2001 B1
6197033 Haid et al. Mar 2001 B1
6197041 Shichman et al. Mar 2001 B1
6197065 Martin et al. Mar 2001 B1
6197325 MacPhee et al. Mar 2001 B1
6200322 Branch et al. Mar 2001 B1
6203565 Bonutti et al. Mar 2001 B1
6206826 Mathews et al. Mar 2001 B1
6206922 Zdeblick et al. Mar 2001 B1
D439980 Reiley et al. Apr 2001 S
6213957 Milliman et al. Apr 2001 B1
6214368 Lee et al. Apr 2001 B1
6217509 Foley et al. Apr 2001 B1
6217579 Koros Apr 2001 B1
6221082 Marino et al. Apr 2001 B1
6224603 Marino May 2001 B1
6224631 Kohrs May 2001 B1
6224894 Jamiolkowski et al. May 2001 B1
6228058 Dennis et al. May 2001 B1
6231606 Graf et al. May 2001 B1
6235030 Zucherman et al. May 2001 B1
6235043 Reiley et al. May 2001 B1
6238397 Zucherman et al. May 2001 B1
6238491 Davidson et al. May 2001 B1
6241733 Nicholson et al. Jun 2001 B1
6241734 Scribner et al. Jun 2001 B1
6241769 Nicholson et al. Jun 2001 B1
6245107 Ferree Jun 2001 B1
6248108 Toermaelae et al. Jun 2001 B1
6248110 Reiley et al. Jun 2001 B1
6248131 Felt et al. Jun 2001 B1
6251111 Barker et al. Jun 2001 B1
6251140 Marino et al. Jun 2001 B1
6258093 Edwards et al. Jul 2001 B1
6261289 Levy Jul 2001 B1
6264676 Gellman et al. Jul 2001 B1
6264695 Stoy Jul 2001 B1
6267763 Castro Jul 2001 B1
6267765 Taylor et al. Jul 2001 B1
6267767 Strobel et al. Jul 2001 B1
6277149 Boyle et al. Aug 2001 B1
6280444 Zucherman et al. Aug 2001 B1
6280456 Scribner et al. Aug 2001 B1
6280474 Cassidy et al. Aug 2001 B1
6280475 Bao et al. Aug 2001 B1
6287313 Sasso Sep 2001 B1
6290724 Marino Sep 2001 B1
6293909 Chu et al. Sep 2001 B1
6293952 Brosens et al. Sep 2001 B1
D449691 Reiley et al. Oct 2001 S
6296644 Saurat et al. Oct 2001 B1
6296647 Robioneck et al. Oct 2001 B1
6302914 Michelson Oct 2001 B1
6306136 Baccelli Oct 2001 B1
6306177 Felt et al. Oct 2001 B1
D450676 Huttner Nov 2001 S
6312443 Stone Nov 2001 B1
6319254 Giet et al. Nov 2001 B1
6319272 Brenneman et al. Nov 2001 B1
6331312 Lee et al. Dec 2001 B1
6332882 Zucherman et al. Dec 2001 B1
6332883 Zucherman et al. Dec 2001 B1
6332894 Stalcup et al. Dec 2001 B1
6332895 Suddaby Dec 2001 B1
6342074 Simpson Jan 2002 B1
6346092 Leschinsky Feb 2002 B1
6348053 Cachia Feb 2002 B1
6355043 Adam Mar 2002 B1
6361537 Anderson Mar 2002 B1
6361538 Fenaroli et al. Mar 2002 B1
6361557 Gittings et al. Mar 2002 B1
6364828 Yeung et al. Apr 2002 B1
6364897 Bonutti Apr 2002 B1
6368325 McKinley et al. Apr 2002 B1
6368350 Erickson et al. Apr 2002 B1
6368351 Glenn et al. Apr 2002 B1
6371971 Tsugita et al. Apr 2002 B1
6371989 Chauvin et al. Apr 2002 B1
6375681 Truscott Apr 2002 B1
6375682 Fleischmann et al. Apr 2002 B1
6375683 Crozet et al. Apr 2002 B1
6379355 Zucherman et al. Apr 2002 B1
6379363 Herrington et al. Apr 2002 B1
6387130 Stone et al. May 2002 B1
6398793 McGuire Jun 2002 B1
6402750 Atkinson et al. Jun 2002 B1
6409766 Brett Jun 2002 B1
6409767 Perice et al. Jun 2002 B1
6413278 Marchosky Jul 2002 B1
6416551 Keller Jul 2002 B1
6419641 Mark et al. Jul 2002 B1
6419676 Zucherman et al. Jul 2002 B1
6419677 Zucherman et al. Jul 2002 B2
6419704 Ferree Jul 2002 B1
6419705 Erickson Jul 2002 B1
6419706 Graf Jul 2002 B1
6423061 Bryant Jul 2002 B1
6423067 Eisermann Jul 2002 B1
6423071 Lawson Jul 2002 B1
6423083 Reiley et al. Jul 2002 B2
6423089 Gingras et al. Jul 2002 B1
6425887 McGuckin et al. Jul 2002 B1
6425919 Lambrecht Jul 2002 B1
6425920 Hamada Jul 2002 B1
6428541 Boyd et al. Aug 2002 B1
6428556 Chin Aug 2002 B1
6436101 Hamada Aug 2002 B1
6436140 Liu et al. Aug 2002 B1
6436143 Ross et al. Aug 2002 B1
6440138 Reiley et al. Aug 2002 B1
6440154 Gellman et al. Aug 2002 B2
6440169 Elberg et al. Aug 2002 B1
6443989 Jackson Sep 2002 B1
6447518 Krause et al. Sep 2002 B1
6447527 Thompson et al. Sep 2002 B1
6447540 Fontaine et al. Sep 2002 B1
6450989 Dubrul et al. Sep 2002 B2
6451019 Zucherman et al. Sep 2002 B1
6451020 Zucherman et al. Sep 2002 B1
6454806 Cohen et al. Sep 2002 B1
6454807 Jackson Sep 2002 B1
6458134 Songer et al. Oct 2002 B1
6461359 Tribus et al. Oct 2002 B1
6468277 Justin et al. Oct 2002 B1
6468279 Reo Oct 2002 B1
6468309 Lieberman Oct 2002 B1
6468310 Ralph et al. Oct 2002 B1
6471724 Zdeblick et al. Oct 2002 B2
6475226 Belef et al. Nov 2002 B1
6478029 Boyd et al. Nov 2002 B1
6478796 Zucherman et al. Nov 2002 B2
6478805 Marino et al. Nov 2002 B1
6482235 Lambrecht et al. Nov 2002 B1
6485491 Farris et al. Nov 2002 B1
6485518 Cornwall et al. Nov 2002 B1
D467657 Scribner Dec 2002 S
6488693 Gannoe et al. Dec 2002 B2
6488710 Besselink Dec 2002 B2
6489309 Singh et al. Dec 2002 B1
6491626 Stone et al. Dec 2002 B1
6491695 Roggenbuck Dec 2002 B1
6491714 Bennett Dec 2002 B1
6491724 Ferree Dec 2002 B1
6494860 Rocamora et al. Dec 2002 B2
6494883 Ferree Dec 2002 B1
6494893 Dubrul et al. Dec 2002 B2
6498421 Oh et al. Dec 2002 B1
6500178 Zucherman et al. Dec 2002 B2
6500205 Michelson Dec 2002 B1
6506192 Gertzman et al. Jan 2003 B1
6508839 Lambrecht et al. Jan 2003 B1
6511471 Rosenman et al. Jan 2003 B2
6511481 Von et al. Jan 2003 B2
6512958 Swoyer et al. Jan 2003 B1
D469871 Sand Feb 2003 S
6514256 Zucherman et al. Feb 2003 B2
6517543 Berrevoets et al. Feb 2003 B1
6517580 Ramadan et al. Feb 2003 B1
6520907 Foley et al. Feb 2003 B1
6520991 Huene Feb 2003 B2
D472323 Sand Mar 2003 S
6527774 Lieberman Mar 2003 B2
6527803 Crozet et al. Mar 2003 B1
6527804 Gauchet et al. Mar 2003 B1
6530930 Marino et al. Mar 2003 B1
6533791 Betz et al. Mar 2003 B1
6533797 Stone et al. Mar 2003 B1
6533818 Weber et al. Mar 2003 B1
6540747 Marino Apr 2003 B1
6544265 Lieberman Apr 2003 B2
6547793 McGuire Apr 2003 B1
6547795 Schneiderman Apr 2003 B2
6547823 Scarborough et al. Apr 2003 B2
6551319 Lieberman Apr 2003 B2
6551322 Lieberman Apr 2003 B1
6554831 Rivard et al. Apr 2003 B1
6554833 Levy et al. Apr 2003 B2
6554852 Oberlander Apr 2003 B1
6558389 Clark et al. May 2003 B2
6558390 Cragg May 2003 B2
6558424 Thalgott May 2003 B2
6562046 Sasso May 2003 B2
6562049 Norlander et al. May 2003 B1
6562072 Fuss et al. May 2003 B1
6562074 Gerbec et al. May 2003 B2
6575919 Reiley et al. Jun 2003 B1
6575979 Cragg Jun 2003 B1
6576016 Hochshuler et al. Jun 2003 B1
6579291 Keith et al. Jun 2003 B1
6579293 Chandran Jun 2003 B1
6579320 Gauchet et al. Jun 2003 B1
6579321 Gordon et al. Jun 2003 B1
6582390 Sanderson Jun 2003 B1
6582431 Ray Jun 2003 B1
6582433 Yun Jun 2003 B2
6582437 Dorchak et al. Jun 2003 B2
6582441 He et al. Jun 2003 B1
6582453 Tran et al. Jun 2003 B1
6582466 Gauchet Jun 2003 B1
6582467 Teitelbaum et al. Jun 2003 B1
6582468 Gauchet Jun 2003 B1
6585730 Foerster Jul 2003 B1
6585740 Schlapfer et al. Jul 2003 B2
6589240 Hinchliffe Jul 2003 B2
6589249 Sater et al. Jul 2003 B2
6592553 Zhang et al. Jul 2003 B2
6592624 Fraser et al. Jul 2003 B1
6592625 Cauthen Jul 2003 B2
6595998 Johnson et al. Jul 2003 B2
6596008 Kambin Jul 2003 B1
6599294 Fuss et al. Jul 2003 B2
6599297 Carlsson et al. Jul 2003 B1
6602293 Biermann et al. Aug 2003 B1
6607530 Carl et al. Aug 2003 B1
6607544 Boucher et al. Aug 2003 B1
6607558 Kuras Aug 2003 B2
6610066 Dinger et al. Aug 2003 B2
6610091 Reiley Aug 2003 B1
6610094 Husson Aug 2003 B2
6613050 Wagner et al. Sep 2003 B1
6613054 Scribner et al. Sep 2003 B2
6616678 Nishtala et al. Sep 2003 B2
6620196 Trieu Sep 2003 B1
6623505 Scribner et al. Sep 2003 B2
6626943 Eberlein et al. Sep 2003 B2
6626944 Taylor Sep 2003 B1
6629998 Lin Oct 2003 B1
6632224 Cachia et al. Oct 2003 B2
6632235 Weikel et al. Oct 2003 B2
6635059 Randall et al. Oct 2003 B2
6635060 Hanson et al. Oct 2003 B2
6635362 Zheng Oct 2003 B2
RE38335 Aust et al. Nov 2003 E
D482787 Reiss Nov 2003 S
6641564 Kraus Nov 2003 B1
6641582 Hanson et al. Nov 2003 B1
6641587 Scribner et al. Nov 2003 B2
6641614 Wagner et al. Nov 2003 B1
6645213 Sand et al. Nov 2003 B2
6645248 Casutt Nov 2003 B2
6648890 Culbert et al. Nov 2003 B2
6648893 Dudasik Nov 2003 B2
6648917 Gerbec et al. Nov 2003 B2
6652527 Zucherman et al. Nov 2003 B2
6652592 Grooms et al. Nov 2003 B1
D483495 Sand Dec 2003 S
6655962 Kennard Dec 2003 B1
6656178 Veldhuizen et al. Dec 2003 B1
6656180 Stahurski Dec 2003 B2
6660004 Barker et al. Dec 2003 B2
6660037 Husson et al. Dec 2003 B1
6663647 Reiley et al. Dec 2003 B2
6666890 Michelson Dec 2003 B2
6666891 Boehm et al. Dec 2003 B2
6669698 Tromanhauser et al. Dec 2003 B1
6669729 Chin Dec 2003 B2
6669732 Serhan et al. Dec 2003 B2
6673074 Shluzas Jan 2004 B2
6676663 Higueras et al. Jan 2004 B2
6676664 Al-Assir Jan 2004 B1
6676665 Foley et al. Jan 2004 B2
6679833 Smith et al. Jan 2004 B2
6679915 Cauthen Jan 2004 B1
6682535 Hoogland Jan 2004 B2
6682561 Songer et al. Jan 2004 B2
6682562 Viart et al. Jan 2004 B2
6685706 Padget et al. Feb 2004 B2
6685742 Jackson Feb 2004 B1
6689125 Keith et al. Feb 2004 B1
6689152 Balceta et al. Feb 2004 B2
6689168 Lieberman Feb 2004 B2
6692499 Toermaelae et al. Feb 2004 B2
6692563 Zimmermann Feb 2004 B2
6695842 Zucherman et al. Feb 2004 B2
6695851 Zdeblick et al. Feb 2004 B2
6699246 Zucherman et al. Mar 2004 B2
6699247 Zucherman et al. Mar 2004 B2
6706070 Wagner et al. Mar 2004 B1
6709458 Michelson Mar 2004 B2
6712819 Zucherman et al. Mar 2004 B2
6716216 Boucher et al. Apr 2004 B1
6716247 Michelson Apr 2004 B2
6716957 Tunc Apr 2004 B2
6719760 Dorchak et al. Apr 2004 B2
6719761 Reiley et al. Apr 2004 B1
6719773 Boucher et al. Apr 2004 B1
6719796 Cohen et al. Apr 2004 B2
6723096 Dorchak et al. Apr 2004 B1
6723126 Berry Apr 2004 B1
6723127 Ralph et al. Apr 2004 B2
6723128 Uk Apr 2004 B2
6726691 Osorio et al. Apr 2004 B2
D490159 Sand May 2004 S
6730126 Boehm et al. May 2004 B2
6733093 Deland et al. May 2004 B2
6733460 Ogura May 2004 B2
6733532 Gauchet et al. May 2004 B1
6733534 Sherman May 2004 B2
6733535 Michelson May 2004 B2
6733635 Ozawa et al. May 2004 B1
6740090 Cragg et al. May 2004 B1
6740093 Hochschuler et al. May 2004 B2
6740117 Ralph et al. May 2004 B2
D492032 Muller et al. Jun 2004 S
6743166 Berci et al. Jun 2004 B2
6743255 Ferree Jun 2004 B2
6746451 Middleton et al. Jun 2004 B2
6749560 Konstorum et al. Jun 2004 B1
6752831 Sybert et al. Jun 2004 B2
6755837 Ebner Jun 2004 B2
6755841 Fraser et al. Jun 2004 B2
D492775 Doelling et al. Jul 2004 S
D493533 Blain Jul 2004 S
6758673 Fromovich et al. Jul 2004 B2
6758847 Maguire Jul 2004 B2
6758861 Ralph et al. Jul 2004 B2
6758862 Berry et al. Jul 2004 B2
6761720 Senegas Jul 2004 B1
6764491 Frey et al. Jul 2004 B2
6764514 Li et al. Jul 2004 B1
D495417 Doelling et al. Aug 2004 S
6770075 Howland Aug 2004 B2
6773460 Jackson Aug 2004 B2
6780151 Grabover et al. Aug 2004 B2
6783530 Levy Aug 2004 B1
6790210 Cragg et al. Sep 2004 B1
6793656 Mathews Sep 2004 B1
6793678 Hawkins Sep 2004 B2
6793679 Michelson Sep 2004 B2
6796983 Zucherman et al. Sep 2004 B1
6805685 Taylor Oct 2004 B2
6805695 Keith et al. Oct 2004 B2
6805697 Helm et al. Oct 2004 B1
6805714 Sutcliffe Oct 2004 B2
6808526 Magerl et al. Oct 2004 B1
6808537 Michelson Oct 2004 B2
6814736 Reiley et al. Nov 2004 B2
6814756 Michelson Nov 2004 B1
6821298 Jackson Nov 2004 B1
6824565 Muhanna et al. Nov 2004 B2
6830589 Erickson Dec 2004 B2
6835205 Atkinson et al. Dec 2004 B2
6835206 Jackson Dec 2004 B2
6835208 Marchosky Dec 2004 B2
6840941 Rogers et al. Jan 2005 B2
6840944 Suddaby Jan 2005 B2
6852126 Ahlgren Feb 2005 B2
6852127 Varga et al. Feb 2005 B2
6852129 Gerbec et al. Feb 2005 B2
6855167 Shimp et al. Feb 2005 B2
6863668 Gillespie et al. Mar 2005 B2
6863672 Reiley et al. Mar 2005 B2
6863673 Gerbec et al. Mar 2005 B2
6866682 An et al. Mar 2005 B1
6875215 Taras et al. Apr 2005 B2
6878167 Ferree Apr 2005 B2
6881228 Zdeblick et al. Apr 2005 B2
6881229 Khandkar et al. Apr 2005 B2
6883520 Lambrecht et al. Apr 2005 B2
6887243 Culbert May 2005 B2
6887248 McKinley et al. May 2005 B2
6890333 Von et al. May 2005 B2
6893464 Kiester May 2005 B2
6893466 Trieu May 2005 B2
6899716 Cragg May 2005 B2
6899719 Reiley et al. May 2005 B2
6899735 Coates et al. May 2005 B2
D506828 Layne et al. Jun 2005 S
6902566 Zucherman et al. Jun 2005 B2
6905512 Paes et al. Jun 2005 B2
6908465 Von et al. Jun 2005 B2
6908506 Zimmermann Jun 2005 B2
6916323 Kitchens Jul 2005 B2
6921403 Cragg et al. Jul 2005 B2
6923810 Michelson Aug 2005 B1
6923811 Carl et al. Aug 2005 B1
6923813 Phillips et al. Aug 2005 B2
6923814 Hildebrand et al. Aug 2005 B1
6929606 Ritland Aug 2005 B2
6929647 Cohen Aug 2005 B2
6936071 Marnay et al. Aug 2005 B1
6936072 Lambrecht et al. Aug 2005 B2
6942668 Padget et al. Sep 2005 B2
6945973 Bray Sep 2005 B2
6945975 Dalton Sep 2005 B2
6946000 Senegas et al. Sep 2005 B2
6949100 Venturini Sep 2005 B1
6949108 Holmes Sep 2005 B2
6951561 Warren et al. Oct 2005 B2
6952129 Lin et al. Oct 2005 B2
6953477 Berry Oct 2005 B2
6955691 Chae et al. Oct 2005 B2
6962606 Michelson Nov 2005 B2
6964674 Matsuura et al. Nov 2005 B1
6964686 Gordon Nov 2005 B2
6966910 Ritland Nov 2005 B2
6966912 Michelson Nov 2005 B2
6969404 Ferree Nov 2005 B2
6969405 Suddaby Nov 2005 B2
D512506 Layne et al. Dec 2005 S
6972035 Michelson Dec 2005 B2
6974479 Trieu Dec 2005 B2
6979341 Scribner et al. Dec 2005 B2
6979352 Reynolds Dec 2005 B2
6979353 Bresina Dec 2005 B2
6981981 Reiley et al. Jan 2006 B2
6997929 Manzi et al. Feb 2006 B2
7004945 Boyd et al. Feb 2006 B2
7004971 Serhan et al. Feb 2006 B2
7008431 Simonson Mar 2006 B2
7008453 Michelson Mar 2006 B1
7014633 Cragg Mar 2006 B2
7018089 Wenz et al. Mar 2006 B2
7018412 Ferreira et al. Mar 2006 B2
7018415 McKay Mar 2006 B1
7018416 Hanson et al. Mar 2006 B2
7018453 Klein et al. Mar 2006 B2
7022138 Mashburn Apr 2006 B2
7025746 Tal Apr 2006 B2
7025787 Bryan et al. Apr 2006 B2
7029473 Zucherman et al. Apr 2006 B2
7029498 Boehm et al. Apr 2006 B2
7037339 Houfburg May 2006 B2
7041107 Pohjonen et al. May 2006 B2
7044954 Reiley et al. May 2006 B2
7048694 Mark et al. May 2006 B2
7048736 Robinson et al. May 2006 B2
7060068 Tromanhauser et al. Jun 2006 B2
7060073 Frey et al. Jun 2006 B2
7063701 Michelson Jun 2006 B2
7063702 Michelson Jun 2006 B2
7063703 Reo Jun 2006 B2
7063725 Foley Jun 2006 B2
7066960 Dickman Jun 2006 B1
7066961 Michelson Jun 2006 B2
7069087 Sharkey et al. Jun 2006 B2
7070598 Lim et al. Jul 2006 B2
7070601 Culbert et al. Jul 2006 B2
7074203 Johanson et al. Jul 2006 B1
7074226 Roehm et al. Jul 2006 B2
7081120 Li et al. Jul 2006 B2
7081122 Reiley et al. Jul 2006 B1
7083650 Moskowitz et al. Aug 2006 B2
7087053 Vanney Aug 2006 B2
7087055 Lim et al. Aug 2006 B2
7087083 Pasquet et al. Aug 2006 B2
7089063 Lesh et al. Aug 2006 B2
7094239 Michelson Aug 2006 B1
7094257 Mujwid et al. Aug 2006 B2
7094258 Lambrecht et al. Aug 2006 B2
7101375 Zucherman et al. Sep 2006 B2
7114501 Johnson et al. Oct 2006 B2
7115128 Michelson Oct 2006 B2
7115163 Zimmermann Oct 2006 B2
7118572 Bramlet et al. Oct 2006 B2
7118579 Michelson Oct 2006 B2
7118580 Beyersdorff et al. Oct 2006 B1
7118598 Michelson Oct 2006 B2
7124761 Lambrecht et al. Oct 2006 B2
7125424 Banick et al. Oct 2006 B2
7128760 Michelson Oct 2006 B2
7135424 Worley et al. Nov 2006 B2
7153304 Robie et al. Dec 2006 B2
7153305 Johnson et al. Dec 2006 B2
7153306 Ralph et al. Dec 2006 B2
7153307 Scribner et al. Dec 2006 B2
D536096 Hoogland et al. Jan 2007 S
7156874 Paponneau et al. Jan 2007 B2
7156875 Michelson Jan 2007 B2
7156876 Moumene et al. Jan 2007 B2
7156877 Lotz et al. Jan 2007 B2
7163558 Senegas et al. Jan 2007 B2
7166107 Anderson Jan 2007 B2
7172612 Ishikawa Feb 2007 B2
7179293 McKay Feb 2007 B2
7179294 Eisermann et al. Feb 2007 B2
7189242 Boyd et al. Mar 2007 B2
7201751 Zucherman et al. Apr 2007 B2
7204851 Trieu et al. Apr 2007 B2
7207991 Michelson Apr 2007 B2
7211112 Baynham et al. May 2007 B2
7214227 Colleran et al. May 2007 B2
7217291 Zucherman et al. May 2007 B2
7217293 Branch, Jr. May 2007 B2
7220280 Kast et al. May 2007 B2
7220281 Lambrecht et al. May 2007 B2
7223227 Pflueger May 2007 B2
7223292 Messerli et al. May 2007 B2
7226481 Kuslich Jun 2007 B2
7226482 Messerli et al. Jun 2007 B2
7226483 Gerber et al. Jun 2007 B2
7235101 Berry et al. Jun 2007 B2
7238204 Le et al. Jul 2007 B2
7241297 Shaolian et al. Jul 2007 B2
7244273 Pedersen et al. Jul 2007 B2
7250060 Trieu Jul 2007 B2
7252671 Scribner et al. Aug 2007 B2
7267683 Sharkey et al. Sep 2007 B2
7267687 McGuckin, Jr. Sep 2007 B2
7270679 Istephanous et al. Sep 2007 B2
7276062 McDaniel et al. Oct 2007 B2
7282061 Sharkey et al. Oct 2007 B2
7291173 Richelsoph et al. Nov 2007 B2
7300440 Zdeblick et al. Nov 2007 B2
7306628 Zucherman et al. Dec 2007 B2
7309357 Kim Dec 2007 B2
7311713 Johnson et al. Dec 2007 B2
7316714 Gordon et al. Jan 2008 B2
7318840 McKay Jan 2008 B2
7320689 Keller Jan 2008 B2
7320708 Bernstein Jan 2008 B1
7322962 Forrest Jan 2008 B2
7326211 Padget et al. Feb 2008 B2
7326248 Michelson Feb 2008 B2
7335203 Winslow et al. Feb 2008 B2
7351262 Bindseil et al. Apr 2008 B2
7361140 Ries et al. Apr 2008 B2
7371238 Soboleski et al. May 2008 B2
7377942 Berry May 2008 B2
7383639 Malandain Jun 2008 B2
7400930 Sharkey et al. Jul 2008 B2
7406775 Funk et al. Aug 2008 B2
7410501 Michelson Aug 2008 B2
7413576 Sybert et al. Aug 2008 B2
7422594 Zander Sep 2008 B2
7434325 Foley et al. Oct 2008 B2
7442211 De et al. Oct 2008 B2
7445636 Michelson Nov 2008 B2
7445637 Taylor Nov 2008 B2
7470273 Dougherty-Shah Dec 2008 B2
D584812 Ries Jan 2009 S
7473256 Assell et al. Jan 2009 B2
7473268 Zucherman et al. Jan 2009 B2
7476251 Zucherman et al. Jan 2009 B2
7485134 Simonson Feb 2009 B2
7488326 Elliott Feb 2009 B2
7491237 Randall et al. Feb 2009 B2
7500991 Bartish et al. Mar 2009 B2
7503920 Siegal Mar 2009 B2
7503933 Michelson Mar 2009 B2
7507241 Levy et al. Mar 2009 B2
7517363 Rogers et al. Apr 2009 B2
7520888 Trieu Apr 2009 B2
7547317 Cragg Jun 2009 B2
7556629 Von et al. Jul 2009 B2
7556651 Humphreys et al. Jul 2009 B2
7569054 Michelson Aug 2009 B2
7569074 Eisermann et al. Aug 2009 B2
7572279 Jackson Aug 2009 B2
7575580 Lim et al. Aug 2009 B2
7575599 Villiers et al. Aug 2009 B2
7578820 Moore et al. Aug 2009 B2
7588574 Assell et al. Sep 2009 B2
7601173 Messerli et al. Oct 2009 B2
7608083 Lee et al. Oct 2009 B2
7618458 Biedermann et al. Nov 2009 B2
7621950 Globerman et al. Nov 2009 B1
7621960 Boyd et al. Nov 2009 B2
7625377 Veldhuizen et al. Dec 2009 B2
7625378 Foley Dec 2009 B2
7625394 Molz et al. Dec 2009 B2
7637905 Saadat et al. Dec 2009 B2
7641657 Cragg Jan 2010 B2
7641670 Davison et al. Jan 2010 B2
7641692 Bryan et al. Jan 2010 B2
7647123 Sharkey et al. Jan 2010 B2
7648523 Mirkovic et al. Jan 2010 B2
7655010 Serhan et al. Feb 2010 B2
7666186 Harp Feb 2010 B2
7666266 Izawa et al. Feb 2010 B2
7670354 Davison et al. Mar 2010 B2
7670374 Schaller Mar 2010 B2
7674265 Smith et al. Mar 2010 B2
7674273 Davison et al. Mar 2010 B2
7682370 Pagliuca et al. Mar 2010 B2
7682400 Zwirkoski Mar 2010 B2
7691120 Shluzas et al. Apr 2010 B2
7691147 Guetlin et al. Apr 2010 B2
7699878 Pavlov et al. Apr 2010 B2
7703727 Selness Apr 2010 B2
7704280 Lechmann et al. Apr 2010 B2
7717944 Foley et al. May 2010 B2
7722530 Davison May 2010 B2
7722612 Sala et al. May 2010 B2
7722674 Grotz May 2010 B1
7727263 Cragg Jun 2010 B2
7731751 Butler et al. Jun 2010 B2
7740633 Assell et al. Jun 2010 B2
7744599 Cragg Jun 2010 B2
7744650 Lindner et al. Jun 2010 B2
7749270 Peterman Jul 2010 B2
7762995 Eversull et al. Jul 2010 B2
7763025 Ainsworth Jul 2010 B2
7763028 Lim et al. Jul 2010 B2
7763038 O'Brien Jul 2010 B2
7763055 Foley Jul 2010 B2
7766930 Dipoto et al. Aug 2010 B2
7771473 Thramann Aug 2010 B2
7771479 Humphreys et al. Aug 2010 B2
7785368 Schaller Aug 2010 B2
7789914 Michelson Sep 2010 B2
7794463 Cragg Sep 2010 B2
7799032 Assell et al. Sep 2010 B2
7799033 Assell et al. Sep 2010 B2
7799036 Davison et al. Sep 2010 B2
7799080 Doty Sep 2010 B2
7799081 McKinley Sep 2010 B2
7799083 Smith et al. Sep 2010 B2
7803161 Foley et al. Sep 2010 B2
D626233 Cipoletti et al. Oct 2010 S
7814429 Buffet et al. Oct 2010 B2
7819921 Grotz Oct 2010 B2
7824410 Simonson et al. Nov 2010 B2
7824429 Culbert et al. Nov 2010 B2
7824445 Biro et al. Nov 2010 B2
7828807 Lehuec et al. Nov 2010 B2
7837734 Zucherman et al. Nov 2010 B2
7846183 Blain Dec 2010 B2
7846206 Oglaza et al. Dec 2010 B2
7850695 Pagliuca et al. Dec 2010 B2
7850733 Baynham et al. Dec 2010 B2
7854766 Moskowitz et al. Dec 2010 B2
7857832 Culbert et al. Dec 2010 B2
7857840 Krebs et al. Dec 2010 B2
7862590 Lim et al. Jan 2011 B2
7862595 Foley et al. Jan 2011 B2
7867259 Foley et al. Jan 2011 B2
7874980 Sonnenschein et al. Jan 2011 B2
7875077 Humphreys et al. Jan 2011 B2
7879098 Simmons, Jr. Feb 2011 B1
7887589 Glenn et al. Feb 2011 B2
7892171 Davison et al. Feb 2011 B2
7892249 Davison et al. Feb 2011 B2
7901438 Culbert et al. Mar 2011 B2
7901459 Hodges et al. Mar 2011 B2
7909870 Kraus Mar 2011 B2
7918874 Siegal Apr 2011 B2
7922719 Ralph et al. Apr 2011 B2
7922729 Michelson Apr 2011 B2
7931674 Zucherman et al. Apr 2011 B2
7931689 Hochschuler et al. Apr 2011 B2
7935051 Miles et al. May 2011 B2
7938832 Culbert et al. May 2011 B2
7942903 Moskowitz et al. May 2011 B2
7947078 Siegal May 2011 B2
7951199 Miller May 2011 B2
7955391 Schaller Jun 2011 B2
7959675 Gately Jun 2011 B2
7963967 Woods Jun 2011 B1
7963993 Schaller Jun 2011 B2
7967864 Schaller Jun 2011 B2
7967865 Schaller Jun 2011 B2
7985231 Sankaran Jul 2011 B2
7993403 Foley et al. Aug 2011 B2
7998176 Culbert Aug 2011 B2
8007535 Hudgins et al. Aug 2011 B2
8012212 Link et al. Sep 2011 B2
8021424 Beger et al. Sep 2011 B2
8021426 Segal et al. Sep 2011 B2
8025697 McClellan et al. Sep 2011 B2
8034109 Zwirkoski Oct 2011 B2
8034110 Garner et al. Oct 2011 B2
8038703 Dobak et al. Oct 2011 B2
8043293 Warnick Oct 2011 B2
8043381 Hestad et al. Oct 2011 B2
8052754 Froehlich Nov 2011 B2
8057544 Schaller Nov 2011 B2
8057545 Hughes et al. Nov 2011 B2
8062375 Glerum et al. Nov 2011 B2
8075621 Michelson Dec 2011 B2
8097036 Cordaro et al. Jan 2012 B2
8100978 Bass Jan 2012 B2
8105382 Olmos et al. Jan 2012 B2
8109972 Zucherman et al. Feb 2012 B2
8109977 Culbert et al. Feb 2012 B2
8114088 Miller Feb 2012 B2
8118871 Gordon Feb 2012 B2
8128700 Delurio et al. Mar 2012 B2
8128702 Zucherman et al. Mar 2012 B2
8133232 Levy et al. Mar 2012 B2
8177812 Sankaran May 2012 B2
8187327 Edidin et al. May 2012 B2
8192495 Simpson et al. Jun 2012 B2
8202322 Doty Jun 2012 B2
8206423 Siegal Jun 2012 B2
8216312 Gray Jul 2012 B2
8216314 Richelsoph Jul 2012 B2
8216317 Thibodeau Jul 2012 B2
8221501 Eisermann et al. Jul 2012 B2
8221502 Branch, Jr. Jul 2012 B2
8221503 Garcia et al. Jul 2012 B2
8231675 Rhoda Jul 2012 B2
8231681 Castleman et al. Jul 2012 B2
8236029 Siegal Aug 2012 B2
8236058 Fabian et al. Aug 2012 B2
8241328 Siegal Aug 2012 B2
8241358 Butler et al. Aug 2012 B2
8241361 Link Aug 2012 B2
8241364 Hansell et al. Aug 2012 B2
8246622 Siegal et al. Aug 2012 B2
8257440 Gordon et al. Sep 2012 B2
8257442 Edie et al. Sep 2012 B2
8262666 Baynham et al. Sep 2012 B2
8262736 Michelson Sep 2012 B2
8267939 Cipoletti et al. Sep 2012 B2
8267965 Gimbel et al. Sep 2012 B2
8273128 Oh et al. Sep 2012 B2
8273129 Baynham et al. Sep 2012 B2
8287599 McGuckin, Jr. Oct 2012 B2
8292959 Webb et al. Oct 2012 B2
8303663 Jimenez et al. Nov 2012 B2
8317866 Palmatier et al. Nov 2012 B2
8323345 Sledge Dec 2012 B2
8328812 Siegal et al. Dec 2012 B2
8328852 Zehavi et al. Dec 2012 B2
8337559 Hansell et al. Dec 2012 B2
8343193 Johnson et al. Jan 2013 B2
8343222 Cope Jan 2013 B2
8353961 McClintock et al. Jan 2013 B2
8361154 Reo Jan 2013 B2
8366777 Matthis et al. Feb 2013 B2
8377098 Landry et al. Feb 2013 B2
8377133 Yuan et al. Feb 2013 B2
8382842 Greenhalgh et al. Feb 2013 B2
8394129 Morgenstern et al. Mar 2013 B2
8398712 De et al. Mar 2013 B2
8398713 Weiman Mar 2013 B2
8403990 Dryer et al. Mar 2013 B2
8409282 Kim Apr 2013 B2
8409290 Zamani et al. Apr 2013 B2
8409291 Blackwell et al. Apr 2013 B2
8414650 Bertele et al. Apr 2013 B2
8425559 Tebbe et al. Apr 2013 B2
8435298 Weiman May 2013 B2
8454617 Schaller et al. Jun 2013 B2
8454698 De et al. Jun 2013 B2
8465524 Siegal Jun 2013 B2
8470043 Schaller et al. Jun 2013 B2
8480715 Gray Jul 2013 B2
8480742 Pisharodi Jul 2013 B2
8486109 Siegal Jul 2013 B2
8486148 Butler et al. Jul 2013 B2
8491591 Feurderer Jul 2013 B2
8491653 Zucherman et al. Jul 2013 B2
8491657 Attia et al. Jul 2013 B2
8491659 Weiman Jul 2013 B2
8506635 Palmatier et al. Aug 2013 B2
8518087 Lopez et al. Aug 2013 B2
8518120 Glerum et al. Aug 2013 B2
8523909 Hess Sep 2013 B2
8523944 Jimenez et al. Sep 2013 B2
8535380 Greenhalgh et al. Sep 2013 B2
8545567 Krueger Oct 2013 B1
8551092 Morgan et al. Oct 2013 B2
8551173 Lechmann et al. Oct 2013 B2
8556978 Schaller Oct 2013 B2
8556979 Glerum et al. Oct 2013 B2
8568481 Olmos et al. Oct 2013 B2
8579977 Fabian Nov 2013 B2
8579981 Lim et al. Nov 2013 B2
8591583 Schaller et al. Nov 2013 B2
8591585 McLaughlin et al. Nov 2013 B2
8597330 Siegal Dec 2013 B2
8597333 Morgenstern et al. Dec 2013 B2
8597360 McLuen et al. Dec 2013 B2
8603168 Gordon et al. Dec 2013 B2
8603170 Cipoletti et al. Dec 2013 B2
8603177 Gray Dec 2013 B2
8623091 Suedkamp et al. Jan 2014 B2
8628576 Triplett et al. Jan 2014 B2
8628577 Jimenez Jan 2014 B1
8628578 Miller et al. Jan 2014 B2
8632595 Weiman Jan 2014 B2
8636746 Jimenez et al. Jan 2014 B2
8641764 Gately Feb 2014 B2
8663329 Ernst Mar 2014 B2
8663331 McClellan et al. Mar 2014 B2
8668740 Rhoda et al. Mar 2014 B2
8672977 Siegal et al. Mar 2014 B2
8679161 Malandain et al. Mar 2014 B2
8679183 Glerum et al. Mar 2014 B2
8685095 Miller et al. Apr 2014 B2
8685098 Glerum et al. Apr 2014 B2
8696751 Ashley et al. Apr 2014 B2
8702757 Thommen et al. Apr 2014 B2
8702798 Matthis et al. Apr 2014 B2
8709086 Glerum Apr 2014 B2
8709088 Kleiner et al. Apr 2014 B2
8715351 Pinto May 2014 B1
8721723 Hansell et al. May 2014 B2
8728160 Globerman et al. May 2014 B2
8728166 Schwab May 2014 B2
8740954 Ghobrial et al. Jun 2014 B2
8753398 Gordon et al. Jun 2014 B2
8758349 Germain et al. Jun 2014 B2
8758441 Hovda et al. Jun 2014 B2
8764806 Abdou Jul 2014 B2
8771360 Jimenez et al. Jul 2014 B2
8777993 Siegal et al. Jul 2014 B2
8778025 Ragab et al. Jul 2014 B2
8795366 Varela Aug 2014 B2
8795374 Chee Aug 2014 B2
8801787 Schaller Aug 2014 B2
8801792 De et al. Aug 2014 B2
8808376 Schaller Aug 2014 B2
8828085 Jensen Sep 2014 B1
8845638 Siegal et al. Sep 2014 B2
8845728 Abdou Sep 2014 B1
8845731 Weiman Sep 2014 B2
8845732 Weiman Sep 2014 B2
8845733 O'Neil et al. Sep 2014 B2
8845734 Weiman Sep 2014 B2
8852242 Morgenstern et al. Oct 2014 B2
8852243 Morgenstern et al. Oct 2014 B2
8852279 Weiman Oct 2014 B2
8864833 Glerum et al. Oct 2014 B2
8888853 Glerum et al. Nov 2014 B2
8888854 Glerum et al. Nov 2014 B2
8900235 Siegal Dec 2014 B2
8900307 Hawkins et al. Dec 2014 B2
8906098 Siegal Dec 2014 B2
8920506 McGuckin, Jr. Dec 2014 B2
8926704 Glerum et al. Jan 2015 B2
8936641 Cain Jan 2015 B2
8940050 Laurence et al. Jan 2015 B2
8940052 Lechmann et al. Jan 2015 B2
8961609 Schaller Feb 2015 B2
8968408 Schaller et al. Mar 2015 B2
8979860 Voellmicke et al. Mar 2015 B2
8979929 Schaller Mar 2015 B2
8986387 To et al. Mar 2015 B1
8986388 Siegal et al. Mar 2015 B2
8986389 Lim et al. Mar 2015 B2
9005291 Loebl et al. Apr 2015 B2
9017408 Siegal et al. Apr 2015 B2
9017413 Siegal et al. Apr 2015 B2
9039767 Raymond et al. May 2015 B2
9039771 Glerum et al. May 2015 B2
9044334 Siegal et al. Jun 2015 B2
9044338 Schaller Jun 2015 B2
9060876 To et al. Jun 2015 B1
9066808 Schaller Jun 2015 B2
9078767 McLean Jul 2015 B1
9089428 Bertele et al. Jul 2015 B2
9095446 Landry et al. Aug 2015 B2
9095447 Barreiro et al. Aug 2015 B2
9101488 Malandain Aug 2015 B2
9101489 Protopsaltis et al. Aug 2015 B2
9101491 Rodgers et al. Aug 2015 B2
9101492 Mangione et al. Aug 2015 B2
9107766 McLean et al. Aug 2015 B1
9254138 Siegal et al. Feb 2016 B2
9259326 Schaller Feb 2016 B2
9271846 Lim et al. Mar 2016 B2
9277928 Morgenstern Lopez Mar 2016 B2
9283092 Siegal et al. Mar 2016 B2
9295562 Lechmann et al. Mar 2016 B2
9320615 Suedkamp et al. Apr 2016 B2
9326866 Schaller et al. May 2016 B2
9333091 Dimauro May 2016 B2
9358123 Remington et al. Jun 2016 B2
9387087 Tyber Jul 2016 B2
9402739 Weiman et al. Aug 2016 B2
9408712 Siegal et al. Aug 2016 B2
9414923 Studer et al. Aug 2016 B2
9414934 Cain Aug 2016 B2
9433510 Lechmann et al. Sep 2016 B2
9439776 Dimauro et al. Sep 2016 B2
9439777 Dimauro Sep 2016 B2
9463099 Levy et al. Oct 2016 B2
9492288 Wagner et al. Nov 2016 B2
9510954 Glerum et al. Dec 2016 B2
9522070 Flower et al. Dec 2016 B2
9597197 Echmann et al. Mar 2017 B2
9662223 Matthis et al. May 2017 B2
9724207 Dimauro et al. Aug 2017 B2
9730803 Dimauro et al. Aug 2017 B2
9788963 Aquino et al. Oct 2017 B2
9801729 Dimauro et al. Oct 2017 B2
9808351 Kelly et al. Nov 2017 B2
9814589 Dimauro Nov 2017 B2
9814590 Serhan et al. Nov 2017 B2
9833334 Voellmicke et al. Dec 2017 B2
9839530 Hawkins et al. Dec 2017 B2
9924978 Thommen et al. Mar 2018 B2
9925060 Dimauro et al. Mar 2018 B2
9949769 Serhan et al. Apr 2018 B2
9980823 Matthis et al. May 2018 B2
10085843 Dimauro Oct 2018 B2
10238500 Rogers et al. Mar 2019 B2
10265191 Lim et al. Apr 2019 B2
10376372 Serhan et al. Aug 2019 B2
10398566 Olmos et al. Sep 2019 B2
10405986 Kelly et al. Sep 2019 B2
10420651 Serhan et al. Sep 2019 B2
10426632 Butler et al. Oct 2019 B2
10433971 Dimauro et al. Oct 2019 B2
10433974 O'Neil Oct 2019 B2
10492918 Dimauro Dec 2019 B2
10512489 Serhan et al. Dec 2019 B2
10555817 Dimauro et al. Feb 2020 B2
10575959 Dimauro et al. Mar 2020 B2
10583013 Dimauro et al. Mar 2020 B2
10583015 Olmos et al. Mar 2020 B2
10639164 Dimauro et al. May 2020 B2
10743914 Lopez Aug 2020 B2
10973652 Hawkins et al. Apr 2021 B2
11051954 Greenhalgh et al. Jul 2021 B2
11103362 Butler et al. Aug 2021 B2
20010011174 Reiley et al. Aug 2001 A1
20010012950 Nishtala et al. Aug 2001 A1
20010016741 Burkus et al. Aug 2001 A1
20010016775 Scarborough et al. Aug 2001 A1
20010027320 Sasso Oct 2001 A1
20010032020 Besselink Oct 2001 A1
20010037126 Stack et al. Nov 2001 A1
20010039452 Zucherman et al. Nov 2001 A1
20010039453 Gresser et al. Nov 2001 A1
20010049529 Cachia et al. Dec 2001 A1
20010049530 Culbert et al. Dec 2001 A1
20010049531 Reiley et al. Dec 2001 A1
20010056302 Boyer et al. Dec 2001 A1
20020001476 Nagamine et al. Jan 2002 A1
20020010070 Cales et al. Jan 2002 A1
20020016583 Cragg Feb 2002 A1
20020026195 Layne et al. Feb 2002 A1
20020026244 Trieu Feb 2002 A1
20020029084 Paul et al. Mar 2002 A1
20020032462 Houser et al. Mar 2002 A1
20020032483 Nicholson et al. Mar 2002 A1
20020035400 Bryan et al. Mar 2002 A1
20020037799 Li et al. Mar 2002 A1
20020045904 Fuss et al. Apr 2002 A1
20020045942 Ham Apr 2002 A1
20020055740 Lieberman May 2002 A1
20020055781 Sazy May 2002 A1
20020058947 Hochschuler et al. May 2002 A1
20020068974 Kuslich et al. Jun 2002 A1
20020068976 Jackson Jun 2002 A1
20020068977 Jackson Jun 2002 A1
20020072801 Michelson Jun 2002 A1
20020077700 Varga et al. Jun 2002 A1
20020077701 Kuslich Jun 2002 A1
20020082584 Rosenman et al. Jun 2002 A1
20020082608 Reiley et al. Jun 2002 A1
20020087152 Mikus et al. Jul 2002 A1
20020087163 Dixon et al. Jul 2002 A1
20020091387 Hoogland Jul 2002 A1
20020091390 Michelson Jul 2002 A1
20020099385 Ralph et al. Jul 2002 A1
20020107519 Dixon et al. Aug 2002 A1
20020107573 Steinberg Aug 2002 A1
20020120335 Angelucci et al. Aug 2002 A1
20020128713 Ferree Sep 2002 A1
20020128715 Bryan et al. Sep 2002 A1
20020128716 Cohen et al. Sep 2002 A1
20020138078 Chappuis Sep 2002 A1
20020138146 Jackson Sep 2002 A1
20020143331 Zucherman et al. Oct 2002 A1
20020143334 Hoffmann et al. Oct 2002 A1
20020143335 Von et al. Oct 2002 A1
20020151895 Soboleski et al. Oct 2002 A1
20020151976 Foley et al. Oct 2002 A1
20020156482 Scribner et al. Oct 2002 A1
20020161444 Choi Oct 2002 A1
20020165612 Gerber et al. Nov 2002 A1
20020169471 Ferdinand Nov 2002 A1
20020172851 Corey et al. Nov 2002 A1
20020173796 Cragg Nov 2002 A1
20020173841 Ortiz et al. Nov 2002 A1
20020173851 McKay Nov 2002 A1
20020183761 Johnson et al. Dec 2002 A1
20020183778 Reiley et al. Dec 2002 A1
20020183848 Ray et al. Dec 2002 A1
20020191487 Sand Dec 2002 A1
20020193883 Wironen Dec 2002 A1
20020198526 Shaolian et al. Dec 2002 A1
20030004575 Erickson Jan 2003 A1
20030004576 Thalgott Jan 2003 A1
20030006942 Searls et al. Jan 2003 A1
20030014112 Ralph et al. Jan 2003 A1
20030014113 Ralph et al. Jan 2003 A1
20030014116 Ralph et al. Jan 2003 A1
20030018390 Husson Jan 2003 A1
20030023305 McKay Jan 2003 A1
20030028250 Reiley et al. Feb 2003 A1
20030028251 Mathews Feb 2003 A1
20030032963 Reiss et al. Feb 2003 A1
20030040796 Ferree Feb 2003 A1
20030040799 Boyd et al. Feb 2003 A1
20030045937 Ginn Mar 2003 A1
20030045939 Casutt Mar 2003 A1
20030050644 Boucher et al. Mar 2003 A1
20030063582 Mizell et al. Apr 2003 A1
20030065330 Zucherman et al. Apr 2003 A1
20030065396 Michelson Apr 2003 A1
20030069582 Culbert Apr 2003 A1
20030069593 Tremulis et al. Apr 2003 A1
20030069642 Ralph et al. Apr 2003 A1
20030073998 Pagliuca et al. Apr 2003 A1
20030074063 Gerbec et al. Apr 2003 A1
20030074075 Thomas et al. Apr 2003 A1
20030078667 Manasas et al. Apr 2003 A1
20030083642 Boyd et al. May 2003 A1
20030083688 Simonson May 2003 A1
20030108588 Chen et al. Jun 2003 A1
20030130664 Boucher et al. Jul 2003 A1
20030130739 Gerbec et al. Jul 2003 A1
20030135275 Garcia et al. Jul 2003 A1
20030139648 Foley et al. Jul 2003 A1
20030139812 Garcia et al. Jul 2003 A1
20030139813 Messerli et al. Jul 2003 A1
20030153874 Tal Aug 2003 A1
20030171812 Grunberg et al. Sep 2003 A1
20030187431 Simonson Oct 2003 A1
20030187445 Keith et al. Oct 2003 A1
20030187506 Ross et al. Oct 2003 A1
20030191414 Reiley et al. Oct 2003 A1
20030191489 Reiley et al. Oct 2003 A1
20030191531 Berry et al. Oct 2003 A1
20030195518 Cragg Oct 2003 A1
20030195547 Scribner et al. Oct 2003 A1
20030195630 Ferree Oct 2003 A1
20030199979 McGuckin Oct 2003 A1
20030204261 Eisermann et al. Oct 2003 A1
20030208122 Melkent et al. Nov 2003 A1
20030208136 Mark et al. Nov 2003 A1
20030208203 Lim et al. Nov 2003 A1
20030208220 Worley et al. Nov 2003 A1
20030220643 Ferree Nov 2003 A1
20030220648 Osorio et al. Nov 2003 A1
20030220695 Sevrain Nov 2003 A1
20030229350 Kay Dec 2003 A1
20030229372 Reiley et al. Dec 2003 A1
20030233096 Osorio et al. Dec 2003 A1
20030233102 Nakamura et al. Dec 2003 A1
20030233145 Landry et al. Dec 2003 A1
20030233146 Grinberg et al. Dec 2003 A1
20040002761 Rogers et al. Jan 2004 A1
20040006391 Reiley Jan 2004 A1
20040008949 Liu et al. Jan 2004 A1
20040010251 Pitaru et al. Jan 2004 A1
20040010260 Scribner et al. Jan 2004 A1
20040010263 Boucher et al. Jan 2004 A1
20040010318 Ferree Jan 2004 A1
20040019354 Johnson et al. Jan 2004 A1
20040019359 Worley et al. Jan 2004 A1
20040024408 Burkus et al. Feb 2004 A1
20040024409 Sand et al. Feb 2004 A1
20040024410 Olson et al. Feb 2004 A1
20040024463 Thomas et al. Feb 2004 A1
20040024465 Lambrecht et al. Feb 2004 A1
20040030387 Landry et al. Feb 2004 A1
20040034343 Gillespie et al. Feb 2004 A1
20040034429 Lambrecht et al. Feb 2004 A1
20040049190 Biedermann et al. Mar 2004 A1
20040049203 Scribner et al. Mar 2004 A1
20040049223 Nishtala et al. Mar 2004 A1
20040049270 Gewirtz Mar 2004 A1
20040054412 Gerbec et al. Mar 2004 A1
20040059333 Carl et al. Mar 2004 A1
20040059337 Hanson et al. Mar 2004 A1
20040059339 Roehm et al. Mar 2004 A1
20040059350 Gordon et al. Mar 2004 A1
20040059418 McKay et al. Mar 2004 A1
20040064144 Johnson et al. Apr 2004 A1
20040068269 Bonati et al. Apr 2004 A1
20040073213 Serhan et al. Apr 2004 A1
20040073308 Kuslich et al. Apr 2004 A1
20040073310 Moumene et al. Apr 2004 A1
20040082953 Petit Apr 2004 A1
20040083000 Keller et al. Apr 2004 A1
20040087947 Lim et al. May 2004 A1
20040088055 Hanson et al. May 2004 A1
20040092933 Shaolian et al. May 2004 A1
20040092948 Stevens et al. May 2004 A1
20040092988 Shaolian et al. May 2004 A1
20040093083 Branch et al. May 2004 A1
20040097924 Lambrecht et al. May 2004 A1
20040097930 Justis et al. May 2004 A1
20040097932 Ray et al. May 2004 A1
20040097941 Weiner et al. May 2004 A1
20040097973 Loshakove et al. May 2004 A1
20040098131 Bryan et al. May 2004 A1
20040102774 Trieu May 2004 A1
20040102784 Pasquet et al. May 2004 A1
20040102846 Keller et al. May 2004 A1
20040106925 Culbert Jun 2004 A1
20040106940 Shaolian et al. Jun 2004 A1
20040111161 Trieu Jun 2004 A1
20040116997 Taylor et al. Jun 2004 A1
20040117019 Trieu et al. Jun 2004 A1
20040117022 Marnay et al. Jun 2004 A1
20040127906 Culbert et al. Jul 2004 A1
20040127990 Bartish et al. Jul 2004 A1
20040127991 Ferree Jul 2004 A1
20040133124 Bates et al. Jul 2004 A1
20040133229 Lambrecht et al. Jul 2004 A1
20040133279 Krueger et al. Jul 2004 A1
20040133280 Trieu Jul 2004 A1
20040138748 Boyer et al. Jul 2004 A1
20040143284 Chin Jul 2004 A1
20040143332 Krueger et al. Jul 2004 A1
20040143734 Buer et al. Jul 2004 A1
20040147129 Rolfson Jul 2004 A1
20040147877 Heuser Jul 2004 A1
20040147950 Mueller et al. Jul 2004 A1
20040148027 Errico et al. Jul 2004 A1
20040153064 Foley et al. Aug 2004 A1
20040153065 Lim Aug 2004 A1
20040153115 Reiley et al. Aug 2004 A1
20040153156 Cohen et al. Aug 2004 A1
20040153160 Carrasco Aug 2004 A1
20040158206 Aboul-Hosn et al. Aug 2004 A1
20040158258 Bonati et al. Aug 2004 A1
20040162617 Zucherman et al. Aug 2004 A1
20040162618 Mujwid et al. Aug 2004 A1
20040167561 Boucher et al. Aug 2004 A1
20040167562 Osorio et al. Aug 2004 A1
20040167625 Beyar et al. Aug 2004 A1
20040172133 Gerber et al. Sep 2004 A1
20040172134 Berry Sep 2004 A1
20040176775 Burkus et al. Sep 2004 A1
20040186052 Iyer et al. Sep 2004 A1
20040186471 Trieu Sep 2004 A1
20040186482 Kolb et al. Sep 2004 A1
20040186528 Ries et al. Sep 2004 A1
20040186570 Rapp Sep 2004 A1
20040186573 Ferree Sep 2004 A1
20040186577 Ferree Sep 2004 A1
20040193271 Fraser et al. Sep 2004 A1
20040193277 Long et al. Sep 2004 A1
20040199162 Von et al. Oct 2004 A1
20040210231 Boucher et al. Oct 2004 A1
20040210310 Trieu Oct 2004 A1
20040215343 Hochschuler et al. Oct 2004 A1
20040215344 Hochschuler et al. Oct 2004 A1
20040220580 Johnson et al. Nov 2004 A1
20040220668 Eisermann et al. Nov 2004 A1
20040220669 Studer Nov 2004 A1
20040220672 Shadduck Nov 2004 A1
20040225292 Sasso et al. Nov 2004 A1
20040225296 Reiss et al. Nov 2004 A1
20040225361 Glenn et al. Nov 2004 A1
20040230191 Frey et al. Nov 2004 A1
20040230309 Dimauro et al. Nov 2004 A1
20040243229 Vidlund et al. Dec 2004 A1
20040243239 Taylor Dec 2004 A1
20040243241 Istephanous et al. Dec 2004 A1
20040249377 Kaes et al. Dec 2004 A1
20040249461 Ferree Dec 2004 A1
20040249466 Liu et al. Dec 2004 A1
20040254520 Porteous et al. Dec 2004 A1
20040254575 Obenchain et al. Dec 2004 A1
20040254644 Taylor Dec 2004 A1
20040260297 Padget et al. Dec 2004 A1
20040260300 Gorensek et al. Dec 2004 A1
20040260397 Lambrecht et al. Dec 2004 A1
20040266257 Ries et al. Dec 2004 A1
20040267271 Scribner et al. Dec 2004 A9
20040267367 O'Neil Dec 2004 A1
20050004578 Lambrecht et al. Jan 2005 A1
20050010292 Carrasco Jan 2005 A1
20050010293 Zucherman et al. Jan 2005 A1
20050010298 Zucherman et al. Jan 2005 A1
20050015148 Jansen et al. Jan 2005 A1
20050015152 Sweeney Jan 2005 A1
20050019365 Frauchiger et al. Jan 2005 A1
20050021041 Michelson Jan 2005 A1
20050033289 Warren et al. Feb 2005 A1
20050033295 Wisnewski Feb 2005 A1
20050033434 Berry Feb 2005 A1
20050033440 Lambrecht et al. Feb 2005 A1
20050038431 Bartish et al. Feb 2005 A1
20050038515 Kunzler Feb 2005 A1
20050038517 Carrison et al. Feb 2005 A1
20050043737 Reiley et al. Feb 2005 A1
20050043796 Grant et al. Feb 2005 A1
20050043800 Paul et al. Feb 2005 A1
20050054948 Goldenberg Mar 2005 A1
20050055097 Grunberg et al. Mar 2005 A1
20050060036 Schultz et al. Mar 2005 A1
20050060038 Lambrecht et al. Mar 2005 A1
20050065519 Michelson Mar 2005 A1
20050065609 Wardlaw Mar 2005 A1
20050065610 Pisharodi Mar 2005 A1
20050069571 Slivka et al. Mar 2005 A1
20050070908 Cragg Mar 2005 A1
20050070911 Carrison et al. Mar 2005 A1
20050070913 Milbocker et al. Mar 2005 A1
20050071011 Ralph et al. Mar 2005 A1
20050080443 Fallin et al. Apr 2005 A1
20050080488 Schultz Apr 2005 A1
20050085912 Arnin et al. Apr 2005 A1
20050090443 Michael John Apr 2005 A1
20050090833 Dipoto Apr 2005 A1
20050090852 Layne et al. Apr 2005 A1
20050090899 Dipoto Apr 2005 A1
20050096745 Andre et al. May 2005 A1
20050102202 Linden et al. May 2005 A1
20050107880 Shimp et al. May 2005 A1
20050113916 Branch, Jr. May 2005 A1
20050113917 Chae et al. May 2005 A1
20050113918 Messerli et al. May 2005 A1
20050113919 Cragg et al. May 2005 A1
20050113927 Malek May 2005 A1
20050113928 Cragg et al. May 2005 A1
20050118228 Trieu Jun 2005 A1
20050118550 Turri Jun 2005 A1
20050119657 Goldsmith Jun 2005 A1
20050119662 Reiley et al. Jun 2005 A1
20050119750 Studer Jun 2005 A1
20050119751 Lawson Jun 2005 A1
20050119752 Williams et al. Jun 2005 A1
20050119754 Trieu et al. Jun 2005 A1
20050124989 Suddaby Jun 2005 A1
20050124992 Ferree Jun 2005 A1
20050124999 Teitelbaum et al. Jun 2005 A1
20050125062 Biedermann et al. Jun 2005 A1
20050125066 McAfee Jun 2005 A1
20050130929 Boyd Jun 2005 A1
20050131267 Talmadge Jun 2005 A1
20050131268 Talmadge Jun 2005 A1
20050131269 Talmadge Jun 2005 A1
20050131406 Reiley et al. Jun 2005 A1
20050131409 Chervitz et al. Jun 2005 A1
20050131411 Culbert Jun 2005 A1
20050131536 Eisermann et al. Jun 2005 A1
20050131538 Chervitz et al. Jun 2005 A1
20050131540 Trieu Jun 2005 A1
20050131541 Trieu Jun 2005 A1
20050137595 Hoffmann et al. Jun 2005 A1
20050137602 Assell et al. Jun 2005 A1
20050142211 Wenz Jun 2005 A1
20050143734 Cachia et al. Jun 2005 A1
20050143763 Ortiz et al. Jun 2005 A1
20050143827 Globerman et al. Jun 2005 A1
20050149022 Shaolian et al. Jul 2005 A1
20050149030 Serhan et al. Jul 2005 A1
20050149034 Assell et al. Jul 2005 A1
20050149191 Cragg et al. Jul 2005 A1
20050149194 Ahlgren Jul 2005 A1
20050149197 Cauthen Jul 2005 A1
20050154396 Foley et al. Jul 2005 A1
20050154463 Trieu Jul 2005 A1
20050154467 Peterman et al. Jul 2005 A1
20050165398 Reiley Jul 2005 A1
20050165406 Assell et al. Jul 2005 A1
20050165420 Cha Jul 2005 A1
20050165484 Ferree Jul 2005 A1
20050165485 Trieu Jul 2005 A1
20050171539 Braun et al. Aug 2005 A1
20050171541 Boehm et al. Aug 2005 A1
20050171552 Johnson et al. Aug 2005 A1
20050171608 Peterman et al. Aug 2005 A1
20050171610 Humphreys et al. Aug 2005 A1
20050177173 Aebi et al. Aug 2005 A1
20050177235 Baynham et al. Aug 2005 A1
20050177240 Blain Aug 2005 A1
20050182412 Johnson et al. Aug 2005 A1
20050182413 Johnson et al. Aug 2005 A1
20050182414 Manzi et al. Aug 2005 A1
20050182418 Boyd Aug 2005 A1
20050187556 Stack et al. Aug 2005 A1
20050187558 Johnson et al. Aug 2005 A1
20050187559 Raymond et al. Aug 2005 A1
20050187564 Jayaraman Aug 2005 A1
20050197702 Coppes et al. Sep 2005 A1
20050197707 Trieu et al. Sep 2005 A1
20050203512 Hawkins et al. Sep 2005 A1
20050216018 Sennett Sep 2005 A1
20050216026 Culbert Sep 2005 A1
20050216081 Taylor Sep 2005 A1
20050216087 Zucherman et al. Sep 2005 A1
20050222681 Richley et al. Oct 2005 A1
20050222684 Ferree Oct 2005 A1
20050228383 Zucherman et al. Oct 2005 A1
20050228391 Levy et al. Oct 2005 A1
20050228397 Malandain et al. Oct 2005 A1
20050234425 Miller et al. Oct 2005 A1
20050234451 Markworth Oct 2005 A1
20050234452 Malandain Oct 2005 A1
20050234456 Malandain Oct 2005 A1
20050240182 Zucherman et al. Oct 2005 A1
20050240189 Rousseau et al. Oct 2005 A1
20050240193 Layne et al. Oct 2005 A1
20050240269 Lambrecht et al. Oct 2005 A1
20050251142 Hoffmann et al. Nov 2005 A1
20050251149 Wenz Nov 2005 A1
20050251260 Gerber et al. Nov 2005 A1
20050256525 Culbert et al. Nov 2005 A1
20050256576 Moskowitz et al. Nov 2005 A1
20050261682 Ferree Nov 2005 A1
20050261684 Shaolian et al. Nov 2005 A1
20050261695 Cragg et al. Nov 2005 A1
20050261769 Moskowitz et al. Nov 2005 A1
20050261781 Sennett et al. Nov 2005 A1
20050267471 Biedermann et al. Dec 2005 A1
20050273166 Sweeney Dec 2005 A1
20050273173 Gordon et al. Dec 2005 A1
20050277938 Parsons Dec 2005 A1
20050278023 Zwirkoski Dec 2005 A1
20050278026 Gordon et al. Dec 2005 A1
20050278027 Hyde, Jr. Dec 2005 A1
20050278029 Trieu Dec 2005 A1
20050283238 Reiley Dec 2005 A1
20050283244 Gordon et al. Dec 2005 A1
20050287071 Wenz Dec 2005 A1
20060004326 Collins et al. Jan 2006 A1
20060004456 McKay Jan 2006 A1
20060004457 Collins et al. Jan 2006 A1
20060004458 Collins et al. Jan 2006 A1
20060009778 Collins et al. Jan 2006 A1
20060009779 Collins et al. Jan 2006 A1
20060009851 Collins et al. Jan 2006 A1
20060015105 Warren et al. Jan 2006 A1
20060015119 Plassky et al. Jan 2006 A1
20060020284 Foley et al. Jan 2006 A1
20060022180 Selness Feb 2006 A1
20060030850 Keegan et al. Feb 2006 A1
20060030872 Culbert et al. Feb 2006 A1
20060030933 Delegge et al. Feb 2006 A1
20060030943 Peterman Feb 2006 A1
20060032621 Martin et al. Feb 2006 A1
20060036241 Siegal Feb 2006 A1
20060036244 Spitler et al. Feb 2006 A1
20060036246 Carl et al. Feb 2006 A1
20060036256 Carl et al. Feb 2006 A1
20060036259 Carl et al. Feb 2006 A1
20060036261 McDonnell Feb 2006 A1
20060036273 Siegal Feb 2006 A1
20060036323 Carl et al. Feb 2006 A1
20060036324 Sachs et al. Feb 2006 A1
20060041258 Galea Feb 2006 A1
20060041314 Millard Feb 2006 A1
20060045904 Aronson Mar 2006 A1
20060058790 Carl et al. Mar 2006 A1
20060058807 Landry et al. Mar 2006 A1
20060058876 McKinley Mar 2006 A1
20060058880 Wysocki et al. Mar 2006 A1
20060064101 Arramon Mar 2006 A1
20060064102 Ebner Mar 2006 A1
20060064171 Trieu Mar 2006 A1
20060064172 Trieu Mar 2006 A1
20060069436 Sutton et al. Mar 2006 A1
20060069439 Zucherman et al. Mar 2006 A1
20060069440 Zucherman et al. Mar 2006 A1
20060074429 Ralph et al. Apr 2006 A1
20060079908 Lieberman Apr 2006 A1
20060084867 Tremblay et al. Apr 2006 A1
20060084977 Lieberman Apr 2006 A1
20060084988 Kim Apr 2006 A1
20060085002 Trieu et al. Apr 2006 A1
20060085009 Truckai et al. Apr 2006 A1
20060085010 Lieberman Apr 2006 A1
20060089642 Diaz et al. Apr 2006 A1
20060089646 Bonutti Apr 2006 A1
20060089654 Lins et al. Apr 2006 A1
20060089715 Truckai et al. Apr 2006 A1
20060089718 Zucherman et al. Apr 2006 A1
20060089719 Trieu Apr 2006 A1
20060095045 Trieu May 2006 A1
20060095046 Trieu et al. May 2006 A1
20060095134 Trieu et al. May 2006 A1
20060095138 Truckai et al. May 2006 A1
20060100622 Jackson May 2006 A1
20060100706 Shadduck et al. May 2006 A1
20060100707 Stinson et al. May 2006 A1
20060106381 Ferree et al. May 2006 A1
20060106397 Lins May 2006 A1
20060106459 Truckai et al. May 2006 A1
20060111715 Jackson May 2006 A1
20060111728 Abdou May 2006 A1
20060111785 O'Neil May 2006 A1
20060119629 An et al. Jun 2006 A1
20060122609 Mirkovic et al. Jun 2006 A1
20060122610 Culbert et al. Jun 2006 A1
20060122701 Kiester Jun 2006 A1
20060122703 Aebi et al. Jun 2006 A1
20060122704 Vresilovic et al. Jun 2006 A1
20060129244 Ensign Jun 2006 A1
20060136062 Dinello et al. Jun 2006 A1
20060136064 Sherman Jun 2006 A1
20060142759 Amin et al. Jun 2006 A1
20060142765 Dixon et al. Jun 2006 A9
20060142776 Iwanari Jun 2006 A1
20060142858 Colleran et al. Jun 2006 A1
20060142864 Cauthen Jun 2006 A1
20060149136 Seto et al. Jul 2006 A1
20060149229 Kwak et al. Jul 2006 A1
20060149237 Markworth et al. Jul 2006 A1
20060149252 Markworth et al. Jul 2006 A1
20060149379 Kuslich et al. Jul 2006 A1
20060149380 Lotz et al. Jul 2006 A1
20060149385 McKay Jul 2006 A1
20060155379 Heneveld et al. Jul 2006 A1
20060161162 Lambrecht et al. Jul 2006 A1
20060161166 Johnson et al. Jul 2006 A1
20060167547 Suddaby Jul 2006 A1
20060167553 Cauthen et al. Jul 2006 A1
20060173545 Cauthen et al. Aug 2006 A1
20060178743 Carter Aug 2006 A1
20060178745 Bartish et al. Aug 2006 A1
20060178746 Bartish et al. Aug 2006 A1
20060184192 Markworth et al. Aug 2006 A1
20060184247 Edidin et al. Aug 2006 A1
20060184248 Edidin et al. Aug 2006 A1
20060189999 Zwirkoski Aug 2006 A1
20060190083 Arnin et al. Aug 2006 A1
20060190085 Cauthen Aug 2006 A1
20060195102 Malandain Aug 2006 A1
20060195103 Padget et al. Aug 2006 A1
20060195191 Sweeney et al. Aug 2006 A1
20060200139 Michelson Sep 2006 A1
20060200164 Michelson Sep 2006 A1
20060200239 Rothman et al. Sep 2006 A1
20060200240 Rothman et al. Sep 2006 A1
20060200241 Rothman et al. Sep 2006 A1
20060200242 Rothman et al. Sep 2006 A1
20060200243 Rothman et al. Sep 2006 A1
20060206116 Yeung Sep 2006 A1
20060206207 Dryer et al. Sep 2006 A1
20060212118 Abernathie Sep 2006 A1
20060217711 Stevens et al. Sep 2006 A1
20060229627 Hunt et al. Oct 2006 A1
20060229629 Manzi et al. Oct 2006 A1
20060235403 Blain Oct 2006 A1
20060235412 Blain Oct 2006 A1
20060235423 Cantu Oct 2006 A1
20060235521 Zucherman et al. Oct 2006 A1
20060235531 Buettner-Janz Oct 2006 A1
20060241643 Lim et al. Oct 2006 A1
20060241663 Rice et al. Oct 2006 A1
20060241770 Rhoda et al. Oct 2006 A1
20060247634 Warner et al. Nov 2006 A1
20060247770 Peterman Nov 2006 A1
20060247771 Peterman et al. Nov 2006 A1
20060247781 Francis Nov 2006 A1
20060253120 Anderson et al. Nov 2006 A1
20060253201 McLuen Nov 2006 A1
20060254784 Hartmann et al. Nov 2006 A1
20060264896 Palmer Nov 2006 A1
20060264939 Zucherman et al. Nov 2006 A1
20060264945 Edidin et al. Nov 2006 A1
20060265067 Zucherman et al. Nov 2006 A1
20060265075 Baumgartner et al. Nov 2006 A1
20060265077 Zwirkoski Nov 2006 A1
20060271049 Zucherman et al. Nov 2006 A1
20060271061 Beyar et al. Nov 2006 A1
20060276897 Winslow et al. Dec 2006 A1
20060276899 Zipnick et al. Dec 2006 A1
20060276901 Zipnick et al. Dec 2006 A1
20060276902 Zipnick et al. Dec 2006 A1
20060282167 Lambrecht et al. Dec 2006 A1
20060287726 Segal et al. Dec 2006 A1
20060287727 Segal et al. Dec 2006 A1
20060293662 Boyer et al. Dec 2006 A1
20060293663 Walkenhorst et al. Dec 2006 A1
20060293753 Thramann Dec 2006 A1
20070006692 Phan Jan 2007 A1
20070010716 Malandain et al. Jan 2007 A1
20070010717 Cragg Jan 2007 A1
20070010824 Malandain et al. Jan 2007 A1
20070010826 Rhoda et al. Jan 2007 A1
20070010844 Gong et al. Jan 2007 A1
20070010845 Gong et al. Jan 2007 A1
20070010846 Leung et al. Jan 2007 A1
20070010848 Leung et al. Jan 2007 A1
20070010886 Banick et al. Jan 2007 A1
20070010889 Francis Jan 2007 A1
20070016191 Culbert et al. Jan 2007 A1
20070032703 Sankaran et al. Feb 2007 A1
20070032790 Aschmann et al. Feb 2007 A1
20070032791 Greenhalgh Feb 2007 A1
20070043361 Malandain et al. Feb 2007 A1
20070043362 Malandain et al. Feb 2007 A1
20070043363 Malandain et al. Feb 2007 A1
20070043440 William et al. Feb 2007 A1
20070048382 Meyer et al. Mar 2007 A1
20070049849 Schwardt et al. Mar 2007 A1
20070049934 Edidin et al. Mar 2007 A1
20070049935 Edidin et al. Mar 2007 A1
20070050034 Schwardt et al. Mar 2007 A1
20070050035 Schwardt et al. Mar 2007 A1
20070055201 Seto et al. Mar 2007 A1
20070055236 Hudgins et al. Mar 2007 A1
20070055237 Edidin et al. Mar 2007 A1
20070055246 Zucherman et al. Mar 2007 A1
20070055264 Parmigiani Mar 2007 A1
20070055265 Schaller Mar 2007 A1
20070055266 Osorio et al. Mar 2007 A1
20070055267 Osorio et al. Mar 2007 A1
20070055271 Schaller Mar 2007 A1
20070055272 Schaller Mar 2007 A1
20070055273 Schaller Mar 2007 A1
20070055274 Appenzeller et al. Mar 2007 A1
20070055275 Schaller Mar 2007 A1
20070055276 Edidin Mar 2007 A1
20070055277 Osorio et al. Mar 2007 A1
20070055278 Osorio et al. Mar 2007 A1
20070055281 Osorio et al. Mar 2007 A1
20070055284 Osorio et al. Mar 2007 A1
20070055300 Osorio et al. Mar 2007 A1
20070055377 Hanson et al. Mar 2007 A1
20070060933 Sankaran et al. Mar 2007 A1
20070060935 Schwardt et al. Mar 2007 A1
20070067034 Chirico et al. Mar 2007 A1
20070067035 Falahee Mar 2007 A1
20070068329 Phan et al. Mar 2007 A1
20070073292 Kohm et al. Mar 2007 A1
20070073399 Zipnick et al. Mar 2007 A1
20070078436 Leung et al. Apr 2007 A1
20070078463 Malandain Apr 2007 A1
20070093689 Steinberg Apr 2007 A1
20070093897 Gerbec et al. Apr 2007 A1
20070093899 Dutoit et al. Apr 2007 A1
20070093901 Grotz et al. Apr 2007 A1
20070093906 Hudgins et al. Apr 2007 A1
20070118132 Culbert et al. May 2007 A1
20070118222 Lang May 2007 A1
20070118223 Allard et al. May 2007 A1
20070123868 Culbert et al. May 2007 A1
20070123891 Ries et al. May 2007 A1
20070123892 Ries et al. May 2007 A1
20070123986 Schaller May 2007 A1
20070129730 Woods et al. Jun 2007 A1
20070135922 Trieu Jun 2007 A1
20070142843 Dye Jun 2007 A1
20070149978 Shezifi et al. Jun 2007 A1
20070150059 Ruberte et al. Jun 2007 A1
20070150060 Trieu Jun 2007 A1
20070150061 Trieu Jun 2007 A1
20070150063 Ruberte et al. Jun 2007 A1
20070150064 Ruberte et al. Jun 2007 A1
20070161992 Kwak et al. Jul 2007 A1
20070162005 Peterson et al. Jul 2007 A1
20070162127 Peterman et al. Jul 2007 A1
20070162132 Messerli Jul 2007 A1
20070162138 Heinz Jul 2007 A1
20070167945 Lange et al. Jul 2007 A1
20070168036 Ainsworth et al. Jul 2007 A1
20070168038 Trieu Jul 2007 A1
20070173939 Kim et al. Jul 2007 A1
20070173940 Hestad et al. Jul 2007 A1
20070178222 Storey et al. Aug 2007 A1
20070179612 Johnson et al. Aug 2007 A1
20070179615 Heinz et al. Aug 2007 A1
20070179616 Braddock et al. Aug 2007 A1
20070179618 Trieu et al. Aug 2007 A1
20070185578 O'Neil et al. Aug 2007 A1
20070191953 Trieu Aug 2007 A1
20070191954 Hansell et al. Aug 2007 A1
20070191959 Hartmann et al. Aug 2007 A1
20070197935 Reiley et al. Aug 2007 A1
20070198023 Sand et al. Aug 2007 A1
20070198025 Trieu et al. Aug 2007 A1
20070198089 Moskowitz et al. Aug 2007 A1
20070203491 Pasquet et al. Aug 2007 A1
20070208423 Messerli et al. Sep 2007 A1
20070208426 Trieu Sep 2007 A1
20070213717 Trieu et al. Sep 2007 A1
20070213737 Schermerhorn et al. Sep 2007 A1
20070213826 Smith et al. Sep 2007 A1
20070219634 Greenhalgh et al. Sep 2007 A1
20070225706 Clark et al. Sep 2007 A1
20070225726 Dye et al. Sep 2007 A1
20070225807 Phan et al. Sep 2007 A1
20070225815 Keith et al. Sep 2007 A1
20070233074 Anderson et al. Oct 2007 A1
20070233076 Trieu Oct 2007 A1
20070233083 Abdou Oct 2007 A1
20070233089 Dipoto et al. Oct 2007 A1
20070233130 Suddaby Oct 2007 A1
20070233244 Lopez et al. Oct 2007 A1
20070233254 Grotz et al. Oct 2007 A1
20070250167 Bray et al. Oct 2007 A1
20070260245 Malandain et al. Nov 2007 A1
20070260255 Haddock et al. Nov 2007 A1
20070260314 Biyani Nov 2007 A1
20070270823 Trieu et al. Nov 2007 A1
20070270954 Wu Nov 2007 A1
20070270957 Heinz Nov 2007 A1
20070270968 Baynham et al. Nov 2007 A1
20070276373 Malandain Nov 2007 A1
20070276375 Rapp Nov 2007 A1
20070276497 Anderson Nov 2007 A1
20070282443 Globerman et al. Dec 2007 A1
20070282449 De et al. Dec 2007 A1
20070288091 Braddock et al. Dec 2007 A1
20070299521 Glenn et al. Dec 2007 A1
20080009877 Sankaran et al. Jan 2008 A1
20080015694 Tribus Jan 2008 A1
20080015701 Garcia et al. Jan 2008 A1
20080021476 Kirschman Jan 2008 A1
20080021556 Edie Jan 2008 A1
20080021557 Trieu Jan 2008 A1
20080021558 Thramann Jan 2008 A1
20080021559 Thramann Jan 2008 A1
20080027437 Johnson et al. Jan 2008 A1
20080027438 Abdou Jan 2008 A1
20080027453 Johnson et al. Jan 2008 A1
20080027454 Johnson et al. Jan 2008 A1
20080027544 Melkent Jan 2008 A1
20080027550 Link et al. Jan 2008 A1
20080033440 Moskowitz et al. Feb 2008 A1
20080045966 Buttermann et al. Feb 2008 A1
20080051890 Waugh et al. Feb 2008 A1
20080051897 Lopez et al. Feb 2008 A1
20080051902 Dwyer Feb 2008 A1
20080058598 Ries et al. Mar 2008 A1
20080058937 Malandain et al. Mar 2008 A1
20080058944 Duplessis et al. Mar 2008 A1
20080065082 Chang et al. Mar 2008 A1
20080065219 Dye Mar 2008 A1
20080071356 Greenhalgh et al. Mar 2008 A1
20080071380 Sweeney Mar 2008 A1
20080077148 Ries et al. Mar 2008 A1
20080077150 Nguyen Mar 2008 A1
20080077241 Nguyen Mar 2008 A1
20080082172 Jackson Apr 2008 A1
20080082173 Delurio et al. Apr 2008 A1
20080091211 Gately Apr 2008 A1
20080097436 Culbert et al. Apr 2008 A1
20080097454 Deridder et al. Apr 2008 A1
20080097611 Mastrorio et al. Apr 2008 A1
20080103601 Biro et al. May 2008 A1
20080108990 Mitchell et al. May 2008 A1
20080108996 Padget et al. May 2008 A1
20080119935 Alvarez May 2008 A1
20080125865 Abdelgany May 2008 A1
20080132934 Reiley et al. Jun 2008 A1
20080133012 McGuckin Jun 2008 A1
20080133017 Beyar et al. Jun 2008 A1
20080140085 Gately et al. Jun 2008 A1
20080140207 Olmos et al. Jun 2008 A1
20080147129 Biedermann et al. Jun 2008 A1
20080147193 Matthis et al. Jun 2008 A1
20080154377 Voellmicke Jun 2008 A1
20080154379 Steiner et al. Jun 2008 A1
20080161927 Savage et al. Jul 2008 A1
20080167657 Greenhalgh Jul 2008 A1
20080172128 Perez-Cruet et al. Jul 2008 A1
20080177306 Lamborne et al. Jul 2008 A1
20080177312 Perez-Cruet et al. Jul 2008 A1
20080177388 Patterson et al. Jul 2008 A1
20080183204 Greenhalgh et al. Jul 2008 A1
20080188945 Boyce et al. Aug 2008 A1
20080195096 Frei Aug 2008 A1
20080195209 Garcia et al. Aug 2008 A1
20080195210 Milijasevic et al. Aug 2008 A1
20080208255 Siegal Aug 2008 A1
20080208344 Kilpela et al. Aug 2008 A1
20080221586 Garcia-Bengochea et al. Sep 2008 A1
20080221687 Viker Sep 2008 A1
20080228225 Trautwein et al. Sep 2008 A1
20080229597 Malandain Sep 2008 A1
20080234732 Landry et al. Sep 2008 A1
20080234733 Scrantz et al. Sep 2008 A1
20080243126 Gutierrez et al. Oct 2008 A1
20080243251 Stad et al. Oct 2008 A1
20080243254 Butler Oct 2008 A1
20080249622 Gray Oct 2008 A1
20080249628 Altarac et al. Oct 2008 A1
20080255563 Farr et al. Oct 2008 A1
20080255574 Dye Oct 2008 A1
20080255618 Fisher et al. Oct 2008 A1
20080262619 Ray Oct 2008 A1
20080269904 Voorhies Oct 2008 A1
20080281346 Greenhalgh et al. Nov 2008 A1
20080281364 Chirico et al. Nov 2008 A1
20080281425 Thalgott et al. Nov 2008 A1
20080287981 Culbert et al. Nov 2008 A1
20080287997 Altarac et al. Nov 2008 A1
20080300685 Carls et al. Dec 2008 A1
20080306537 Culbert Dec 2008 A1
20080312743 Vila et al. Dec 2008 A1
20080319477 Justis et al. Dec 2008 A1
20090005870 Hawkins et al. Jan 2009 A1
20090005873 Slivka et al. Jan 2009 A1
20090018524 Greenhalgh et al. Jan 2009 A1
20090030423 Puno Jan 2009 A1
20090048631 Bhatnagar et al. Feb 2009 A1
20090048678 Saal et al. Feb 2009 A1
20090054898 Gleason Feb 2009 A1
20090054911 Mueller et al. Feb 2009 A1
20090054988 Hess Feb 2009 A1
20090054991 Biyani et al. Feb 2009 A1
20090062807 Song Mar 2009 A1
20090069813 Von et al. Mar 2009 A1
20090069895 Gittings et al. Mar 2009 A1
20090076607 Aalsma et al. Mar 2009 A1
20090076610 Afzal Mar 2009 A1
20090088789 O'Neil et al. Apr 2009 A1
20090099568 Lowry et al. Apr 2009 A1
20090105712 Dauster et al. Apr 2009 A1
20090105745 Culbert Apr 2009 A1
20090112217 Hester Apr 2009 A1
20090112320 Kraus Apr 2009 A1
20090112324 Refai Apr 2009 A1
20090131986 Lee et al. May 2009 A1
20090143859 McClellan et al. Jun 2009 A1
20090149857 Culbert et al. Jun 2009 A1
20090164020 Janowski et al. Jun 2009 A1
20090177281 Swanson et al. Jul 2009 A1
20090177284 Rogers et al. Jul 2009 A1
20090182429 Humphreys et al. Jul 2009 A1
20090192614 Beger et al. Jul 2009 A1
20090192616 Zielinski Jul 2009 A1
20090198339 Kleiner et al. Aug 2009 A1
20090216234 Farr et al. Aug 2009 A1
20090221967 Thommen et al. Sep 2009 A1
20090222043 Altarac et al. Sep 2009 A1
20090222096 Trieu Sep 2009 A1
20090222099 Liu et al. Sep 2009 A1
20090222100 Cipoletti et al. Sep 2009 A1
20090234364 Crook Sep 2009 A1
20090234389 Chuang et al. Sep 2009 A1
20090234398 Chirico et al. Sep 2009 A1
20090240333 Trudeau et al. Sep 2009 A1
20090240334 Richelsoph Sep 2009 A1
20090240335 Arcenio et al. Sep 2009 A1
20090248159 Aflatoon Oct 2009 A1
20090248163 King et al. Oct 2009 A1
20090275890 Leibowitz et al. Nov 2009 A1
20090276049 Weiland Nov 2009 A1
20090276051 Arramon et al. Nov 2009 A1
20090292361 Lopez Nov 2009 A1
20090299479 Jones et al. Dec 2009 A1
20100016905 Greenhalgh et al. Jan 2010 A1
20100016968 Moore Jan 2010 A1
20100030217 Mitusina Feb 2010 A1
20100040332 Van et al. Feb 2010 A1
20100042218 Nebosky et al. Feb 2010 A1
20100049324 Valdevit et al. Feb 2010 A1
20100076492 Warner et al. Mar 2010 A1
20100076502 Guyer et al. Mar 2010 A1
20100076559 Bagga et al. Mar 2010 A1
20100082109 Greenhalgh et al. Apr 2010 A1
20100094422 Hansell et al. Apr 2010 A1
20100094424 Woodburn et al. Apr 2010 A1
20100094426 Grohowski et al. Apr 2010 A1
20100100098 Norton et al. Apr 2010 A1
20100100183 Prewett et al. Apr 2010 A1
20100106191 Yue et al. Apr 2010 A1
20100114105 Butters et al. May 2010 A1
20100114147 Biyani May 2010 A1
20100125334 Krueger May 2010 A1
20100174314 Mirkovic et al. Jul 2010 A1
20100179594 Theofilos et al. Jul 2010 A1
20100185290 Compton et al. Jul 2010 A1
20100191241 McCormack et al. Jul 2010 A1
20100191334 Keller Jul 2010 A1
20100191336 Greenhalgh Jul 2010 A1
20100204795 Greenhalgh Aug 2010 A1
20100211107 Muhanna Aug 2010 A1
20100211176 Greenhalgh Aug 2010 A1
20100211182 Zimmermann Aug 2010 A1
20100217269 Landes Aug 2010 A1
20100234849 Bouadi Sep 2010 A1
20100234956 Attia et al. Sep 2010 A1
20100249935 Slivka et al. Sep 2010 A1
20100256768 Lim et al. Oct 2010 A1
20100262240 Chavatte et al. Oct 2010 A1
20100268231 Kuslich et al. Oct 2010 A1
20100268338 Melkent et al. Oct 2010 A1
20100274358 Mueller et al. Oct 2010 A1
20100286783 Lechmann et al. Nov 2010 A1
20100292700 Ries Nov 2010 A1
20100298938 Humphreys et al. Nov 2010 A1
20100305700 Ben-Arye et al. Dec 2010 A1
20100305704 Messerli et al. Dec 2010 A1
20100324607 Davis Dec 2010 A1
20100331845 Foley et al. Dec 2010 A1
20100331891 Culbert et al. Dec 2010 A1
20110004216 Amendola et al. Jan 2011 A1
20110004308 Marino et al. Jan 2011 A1
20110004310 Michelson Jan 2011 A1
20110009970 Puno Jan 2011 A1
20110015747 McManus et al. Jan 2011 A1
20110029082 Hall Feb 2011 A1
20110029083 Hynes et al. Feb 2011 A1
20110029085 Hynes et al. Feb 2011 A1
20110035011 Cain Feb 2011 A1
20110046674 Calvosa et al. Feb 2011 A1
20110054538 Zehavi et al. Mar 2011 A1
20110071527 Nelson et al. Mar 2011 A1
20110082552 Wistrom et al. Apr 2011 A1
20110093074 Glerum et al. Apr 2011 A1
20110093076 Reo et al. Apr 2011 A1
20110098531 To Apr 2011 A1
20110098628 Yeung et al. Apr 2011 A1
20110098818 Brodke et al. Apr 2011 A1
20110130835 Ashley et al. Jun 2011 A1
20110130838 Morgenstern Lopez Jun 2011 A1
20110144692 Saladin et al. Jun 2011 A1
20110144753 Marchek et al. Jun 2011 A1
20110153020 Abdelgany et al. Jun 2011 A1
20110159070 Jin et al. Jun 2011 A1
20110160773 Aschmann et al. Jun 2011 A1
20110172716 Glerum Jul 2011 A1
20110172774 Varela Jul 2011 A1
20110190891 Suh et al. Aug 2011 A1
20110238072 Tyndall Sep 2011 A1
20110270261 Mast et al. Nov 2011 A1
20110276142 Niemiec et al. Nov 2011 A1
20110282453 Greenhalgh et al. Nov 2011 A1
20110282459 McClellan et al. Nov 2011 A1
20110301711 Palmatier et al. Dec 2011 A1
20110301712 Palmatier et al. Dec 2011 A1
20110307010 Pradhan Dec 2011 A1
20110313465 Warren et al. Dec 2011 A1
20110320000 O'Neil Dec 2011 A1
20120004726 Greenhalgh et al. Jan 2012 A1
20120004732 Goel et al. Jan 2012 A1
20120010715 Spann Jan 2012 A1
20120022654 Farris et al. Jan 2012 A1
20120029636 Ragab et al. Feb 2012 A1
20120029639 Blackwell et al. Feb 2012 A1
20120035730 Spann Feb 2012 A1
20120059474 Weiman Mar 2012 A1
20120059475 Weiman Mar 2012 A1
20120071977 Oglaza et al. Mar 2012 A1
20120071980 Purcell et al. Mar 2012 A1
20120083889 Purcell et al. Apr 2012 A1
20120123546 Medina May 2012 A1
20120136443 Wenzel May 2012 A1
20120150304 Glerum et al. Jun 2012 A1
20120150305 Glerum et al. Jun 2012 A1
20120158146 Glerum et al. Jun 2012 A1
20120158147 Glerum et al. Jun 2012 A1
20120158148 Glerum et al. Jun 2012 A1
20120185049 Varela Jul 2012 A1
20120197299 Fabian, Jr. Aug 2012 A1
20120197403 Merves Aug 2012 A1
20120197405 Cuevas et al. Aug 2012 A1
20120203290 Warren et al. Aug 2012 A1
20120203347 Glerum et al. Aug 2012 A1
20120215262 Culbert et al. Aug 2012 A1
20120215316 Mohr et al. Aug 2012 A1
20120226357 Varela Sep 2012 A1
20120232552 Morgenstern et al. Sep 2012 A1
20120232658 Morgenstern et al. Sep 2012 A1
20120253395 Linares Oct 2012 A1
20120265309 Glerum et al. Oct 2012 A1
20120277795 Von et al. Nov 2012 A1
20120277869 Siccardi et al. Nov 2012 A1
20120277877 Smith et al. Nov 2012 A1
20120290090 Glerum et al. Nov 2012 A1
20120290097 Cipoletti et al. Nov 2012 A1
20120310350 Farris et al. Dec 2012 A1
20120310352 Dimauro et al. Dec 2012 A1
20120323327 McAfee Dec 2012 A1
20120323328 Weiman Dec 2012 A1
20120330421 Weiman Dec 2012 A1
20120330422 Weiman Dec 2012 A1
20130006361 Glerum et al. Jan 2013 A1
20130023993 Weiman Jan 2013 A1
20130023994 Glerum Jan 2013 A1
20130030536 Rhoda et al. Jan 2013 A1
20130030544 Studer Jan 2013 A1
20130053966 Jimenez Feb 2013 A1
20130060337 Petersheim et al. Mar 2013 A1
20130073044 Gamache Mar 2013 A1
20130085572 Glerum et al. Apr 2013 A1
20130085574 Sledge Apr 2013 A1
20130110240 Hansell et al. May 2013 A1
20130116791 Theofilos May 2013 A1
20130123924 Butler et al. May 2013 A1
20130123927 Malandain May 2013 A1
20130138214 Greenhalgh et al. May 2013 A1
20130144387 Walker et al. Jun 2013 A1
20130144388 Emery et al. Jun 2013 A1
20130158663 Miller et al. Jun 2013 A1
20130158664 Palmatier et al. Jun 2013 A1
20130158667 Tabor et al. Jun 2013 A1
20130158668 Nichols et al. Jun 2013 A1
20130158669 Sungarian et al. Jun 2013 A1
20130173004 Greenhalgh et al. Jul 2013 A1
20130190875 Shulock et al. Jul 2013 A1
20130190876 Drochner et al. Jul 2013 A1
20130190877 Medina Jul 2013 A1
20130197647 Wolters et al. Aug 2013 A1
20130204371 McLuen et al. Aug 2013 A1
20130211525 McLuen et al. Aug 2013 A1
20130211526 Alheidt et al. Aug 2013 A1
20130218276 Fiechter et al. Aug 2013 A1
20130231747 Olmos et al. Sep 2013 A1
20130253585 Garcia et al. Sep 2013 A1
20130261746 Linares et al. Oct 2013 A1
20130310939 Fabian et al. Nov 2013 A1
20130325128 Perloff et al. Dec 2013 A1
20140025169 Lechmann et al. Jan 2014 A1
20140039622 Glerum et al. Feb 2014 A1
20140039626 Mitchell Feb 2014 A1
20140046333 Johnson et al. Feb 2014 A1
20140046446 Robinson Feb 2014 A1
20140052259 Garner et al. Feb 2014 A1
20140058513 Gahman et al. Feb 2014 A1
20140067073 Hauck Mar 2014 A1
20140081267 Orsak et al. Mar 2014 A1
20140086962 Jin et al. Mar 2014 A1
20140094916 Glerum et al. Apr 2014 A1
20140100662 Patterson Apr 2014 A1
20140114414 Abdou et al. Apr 2014 A1
20140114423 Suedkamp et al. Apr 2014 A1
20140128977 Glerum et al. May 2014 A1
20140128980 Kirschman May 2014 A1
20140135934 Hansell et al. May 2014 A1
20140142706 Hansell et al. May 2014 A1
20140163682 Lott Jun 2014 A1
20140163683 Seifert et al. Jun 2014 A1
20140172106 To et al. Jun 2014 A1
20140180421 Glerum et al. Jun 2014 A1
20140188225 Dmuschewsky Jul 2014 A1
20140228959 Niemiec et al. Aug 2014 A1
20140236296 Wagner et al. Aug 2014 A1
20140243981 Davenport et al. Aug 2014 A1
20140243982 Miller Aug 2014 A1
20140249629 Moskowitz et al. Sep 2014 A1
20140249630 Weiman Sep 2014 A1
20140257484 Flower et al. Sep 2014 A1
20140257486 Alheidt Sep 2014 A1
20140257494 Thorwarth et al. Sep 2014 A1
20140277139 Vrionis et al. Sep 2014 A1
20140277204 Sandhu Sep 2014 A1
20140277464 Richter et al. Sep 2014 A1
20140277474 Robinson et al. Sep 2014 A1
20140277476 McLean et al. Sep 2014 A1
20140277481 Lee et al. Sep 2014 A1
20140303731 Glerum Oct 2014 A1
20140303732 Rhoda et al. Oct 2014 A1
20140324171 Glerum et al. Oct 2014 A1
20150012097 Ibarra et al. Jan 2015 A1
20150012098 Eastlack et al. Jan 2015 A1
20150045894 Hawkins et al. Feb 2015 A1
20150066145 Rogers et al. Mar 2015 A1
20150088256 Ballard Mar 2015 A1
20150094610 Morgenstern et al. Apr 2015 A1
20150094812 Cain Apr 2015 A1
20150094813 Lechmann et al. Apr 2015 A1
20150100128 Glerum et al. Apr 2015 A1
20150112398 Morgenstern et al. Apr 2015 A1
20150112437 Davis et al. Apr 2015 A1
20150112438 McLean Apr 2015 A1
20150157470 Voellmicke et al. Jun 2015 A1
20150164655 Dimauro Jun 2015 A1
20150173914 Dimauro et al. Jun 2015 A1
20150173916 Cain Jun 2015 A1
20150182347 Robinson Jul 2015 A1
20150190242 Blain et al. Jul 2015 A1
20150196401 Dimauro et al. Jul 2015 A1
20150202052 Dimauro Jul 2015 A1
20150216671 Cain Aug 2015 A1
20150216672 Cain Aug 2015 A1
20150216673 Dimauro Aug 2015 A1
20150230932 Schaller Aug 2015 A1
20150238324 Nebosky et al. Aug 2015 A1
20150250606 McLean Sep 2015 A1
20150320571 Lechmann et al. Nov 2015 A1
20160000577 Dimauro Jan 2016 A1
20160016309 Swift et al. Jan 2016 A1
20160022437 Kelly et al. Jan 2016 A1
20160038301 Wickham Feb 2016 A1
20160038304 Aquino et al. Feb 2016 A1
20160045333 Baynham Feb 2016 A1
20160051376 Serhan et al. Feb 2016 A1
20160058573 Dimauro et al. Mar 2016 A1
20160067055 Hawkins et al. Mar 2016 A1
20160074170 Rogers et al. Mar 2016 A1
20160074175 O'Neil Mar 2016 A1
20160081814 Baynham Mar 2016 A1
20160089247 Nichols et al. Mar 2016 A1
20160100954 Rumi et al. Apr 2016 A1
20160106551 Grimberg et al. Apr 2016 A1
20160113776 Capote Apr 2016 A1
20160120662 Schaller May 2016 A1
20160128843 Tsau et al. May 2016 A1
20160199196 Serhan et al. Jul 2016 A1
20160228258 Schaller et al. Aug 2016 A1
20160242929 Voellmicke et al. Aug 2016 A1
20160256291 Miller Sep 2016 A1
20160310296 Dimauro et al. Oct 2016 A1
20160317313 Dimauro Nov 2016 A1
20160317317 Marchek et al. Nov 2016 A1
20160317714 Dimauro et al. Nov 2016 A1
20160331541 Dimauro et al. Nov 2016 A1
20160331546 Lechmann et al. Nov 2016 A1
20160331548 Dimauro et al. Nov 2016 A1
20160338854 Serhan et al. Nov 2016 A1
20160367265 Morgenstern Lopez Dec 2016 A1
20160367380 Dimauro Dec 2016 A1
20160374821 Dimauro et al. Dec 2016 A1
20170000622 Thommen et al. Jan 2017 A1
20170035578 Dimauro et al. Feb 2017 A1
20170095341 Smith Apr 2017 A1
20170100255 Hleihil et al. Apr 2017 A1
20170290674 Olmos et al. Oct 2017 A1
20170290675 Olmos et al. Oct 2017 A1
20170290677 Olmos et al. Oct 2017 A1
20170304074 Dimauro et al. Oct 2017 A1
20180055649 Kelly et al. Mar 2018 A1
20180078379 Serhan et al. Mar 2018 A1
20180161171 Frasier et al. Jun 2018 A1
20180161175 Frasier et al. Jun 2018 A1
20180193164 Shoshtaev Jul 2018 A1
20190083276 Dimauro Mar 2019 A1
20190105171 Rogers et al. Apr 2019 A1
20200008950 Serhan et al. Jan 2020 A1
20200015982 O'Neil Jan 2020 A1
20200297506 Olmos et al. Sep 2020 A1
20200405497 Olmos et al. Dec 2020 A1
20210000160 Olmos et al. Jan 2021 A1
Foreign Referenced Citations (267)
Number Date Country
2006279558 Feb 2007 AU
2005314079 Jul 2012 AU
2617872 Feb 2007 CA
1177918 Apr 1998 CN
1383790 Dec 2002 CN
1819805 Aug 2006 CN
101031260 Sep 2007 CN
101087566 Dec 2007 CN
101185594 May 2008 CN
101631516 Jan 2010 CN
101909548 Dec 2010 CN
102164552 Aug 2011 CN
104023674 Sep 2014 CN
2804936 Aug 1979 DE
3023353 Apr 1981 DE
3801459 Aug 1989 DE
3911610 Oct 1990 DE
4012622 Jul 1991 DE
9407806 Jul 1994 DE
19710392 Jul 1999 DE
19832798 Nov 1999 DE
20101793 May 2001 DE
202006005868 Jun 2006 DE
202008001079 Mar 2008 DE
10357960 Sep 2015 DE
0077159 Apr 1983 EP
0260044 Mar 1988 EP
0270704 Jun 1988 EP
0282161 Sep 1988 EP
0433717 Jun 1991 EP
0509084 Oct 1992 EP
0525352 Feb 1993 EP
0529275 Mar 1993 EP
0609084 Aug 1994 EP
0611557 Aug 1994 EP
0621020 Oct 1994 EP
0625336 Nov 1994 EP
0678489 Oct 1995 EP
0743045 Nov 1996 EP
0853929 Jul 1998 EP
1046376 Oct 2000 EP
1157676 Nov 2001 EP
1283026 Feb 2003 EP
1290985 Mar 2003 EP
1308132 May 2003 EP
1374784 Jan 2004 EP
1378205 Jan 2004 EP
1405602 Apr 2004 EP
1532949 May 2005 EP
1541096 Jun 2005 EP
1605836 Dec 2005 EP
1385449 Jul 2006 EP
1683593 Jul 2006 EP
1698305 Sep 2006 EP
1829486 Sep 2007 EP
1843723 Oct 2007 EP
1845874 Oct 2007 EP
1924227 May 2008 EP
1925272 May 2008 EP
2331023 Jun 2011 EP
2368529 Sep 2011 EP
2237748 Sep 2012 EP
2641571 Sep 2013 EP
2705809 Mar 2014 EP
2764851 Aug 2014 EP
2645965 Aug 2016 EP
2649311 Jan 1991 FR
2699065 Jun 1994 FR
2712486 May 1995 FR
2718635 Oct 1995 FR
2728778 Jul 1996 FR
2730159 Aug 1996 FR
2745709 Sep 1997 FR
2800601 May 2001 FR
2801189 May 2001 FR
2808182 Nov 2001 FR
2874814 Mar 2006 FR
2913331 Sep 2008 FR
2948277 Jan 2011 FR
2157788 Oct 1985 GB
2173565 Oct 1986 GB
64-052439 Feb 1989 JP
06-500039 Jan 1994 JP
06-319742 Nov 1994 JP
07-502419 Mar 1995 JP
07-184922 Jul 1995 JP
07-213533 Aug 1995 JP
10-085232 Apr 1998 JP
11-089854 Apr 1999 JP
2003-010197 Jan 2003 JP
2003-126266 May 2003 JP
2003-526457 Sep 2003 JP
2006-501901 Jan 2006 JP
2006-516456 Jul 2006 JP
2007-054666 Mar 2007 JP
2007-530243 Nov 2007 JP
2008-507363 Mar 2008 JP
2008-126085 Jun 2008 JP
2011-509766 Mar 2011 JP
2011-520580 Jul 2011 JP
2012-020153 Feb 2012 JP
4988203 Aug 2012 JP
5164571 Mar 2013 JP
2014-502867 Feb 2014 JP
9109572 Jul 1991 WO
9204423 Mar 1992 WO
9207594 May 1992 WO
9214423 Sep 1992 WO
9304634 Mar 1993 WO
9304652 Mar 1993 WO
9317669 Sep 1993 WO
9404100 Mar 1994 WO
9531158 Nov 1995 WO
9628100 Sep 1996 WO
9700054 Jan 1997 WO
9726847 Jul 1997 WO
9834552 Aug 1998 WO
9834568 Aug 1998 WO
9902214 Jan 1999 WO
9926562 Jun 1999 WO
9942062 Aug 1999 WO
9952478 Oct 1999 WO
9953871 Oct 1999 WO
9960956 Dec 1999 WO
9962417 Dec 1999 WO
9963914 Dec 1999 WO
0012033 Mar 2000 WO
0013620 Mar 2000 WO
0024343 May 2000 WO
0067652 May 2000 WO
0044288 Aug 2000 WO
0053127 Sep 2000 WO
0067650 Nov 2000 WO
0067651 Nov 2000 WO
0074605 Dec 2000 WO
0076409 Dec 2000 WO
0101893 Jan 2001 WO
0101895 Jan 2001 WO
0110316 Feb 2001 WO
0112054 Feb 2001 WO
0117464 Mar 2001 WO
0180751 Nov 2001 WO
0195838 Dec 2001 WO
0203870 Jan 2002 WO
0217824 Mar 2002 WO
0217825 Mar 2002 WO
0230338 Apr 2002 WO
0243601 Jun 2002 WO
0243628 Jun 2002 WO
0245627 Jun 2002 WO
0247563 Jun 2002 WO
0271921 Sep 2002 WO
0285250 Oct 2002 WO
0302021 Jan 2003 WO
0305937 Jan 2003 WO
0307854 Jan 2003 WO
0320169 Mar 2003 WO
0321308 Mar 2003 WO
0322165 Mar 2003 WO
0328587 Apr 2003 WO
0343488 May 2003 WO
0303951 Jun 2003 WO
2003101308 Dec 2003 WO
20041008949 Jan 2004 WO
0359180 Mar 2004 WO
2004030582 Apr 2004 WO
2004034924 Apr 2004 WO
2004062505 Jul 2004 WO
2004069033 Aug 2004 WO
20041064603 Aug 2004 WO
2004073563 Sep 2004 WO
2004080316 Sep 2004 WO
2004082526 Sep 2004 WO
20041078220 Sep 2004 WO
20041078221 Sep 2004 WO
2004098420 Nov 2004 WO
20041098453 Nov 2004 WO
2004108022 Dec 2004 WO
2005027734 Mar 2005 WO
2005032433 Apr 2005 WO
2005039455 May 2005 WO
20051051246 Jun 2005 WO
2005081877 Sep 2005 WO
2005094297 Oct 2005 WO
2005115261 Dec 2005 WO
20051112834 Dec 2005 WO
20051112835 Dec 2005 WO
20061017507 Feb 2006 WO
2006044920 Apr 2006 WO
2006047645 May 2006 WO
20061047587 May 2006 WO
2006058079 Jun 2006 WO
2006060420 Jun 2006 WO
2006066228 Jun 2006 WO
20061058281 Jun 2006 WO
20061063083 Jun 2006 WO
20061065419 Jun 2006 WO
2006072941 Jul 2006 WO
20061081843 Aug 2006 WO
20061108067 Oct 2006 WO
2006118944 Nov 2006 WO
20071009107 Jan 2007 WO
2007022194 Feb 2007 WO
20071028098 Mar 2007 WO
20071048012 Apr 2007 WO
2007067726 Jun 2007 WO
2007084427 Jul 2007 WO
20071119212 Oct 2007 WO
20071124130 Nov 2007 WO
2008005627 Jan 2008 WO
2008011378 Jan 2008 WO
2008044057 Apr 2008 WO
2008064842 Jun 2008 WO
2008070863 Jun 2008 WO
2008103781 Aug 2008 WO
2008103832 Aug 2008 WO
2009064787 May 2009 WO
2009092102 Jul 2009 WO
2009124269 Oct 2009 WO
2009143496 Nov 2009 WO
2009147527 Dec 2009 WO
2009152919 Dec 2009 WO
2010011348 Jan 2010 WO
2010068725 Jun 2010 WO
2010075451 Jul 2010 WO
2010075555 Jul 2010 WO
2010088766 Aug 2010 WO
2010121002 Oct 2010 WO
2010136170 Dec 2010 WO
2010148112 Dec 2010 WO
2011013047 Feb 2011 WO
2011046459 Apr 2011 WO
2011046460 Apr 2011 WO
2011060087 May 2011 WO
2011079910 Jul 2011 WO
2011119617 Sep 2011 WO
2011142761 Nov 2011 WO
2011150350 Dec 2011 WO
2012009152 Jan 2012 WO
2012027490 Mar 2012 WO
2012028182 Mar 2012 WO
2012030331 Mar 2012 WO
2012089317 Jul 2012 WO
2012103254 Aug 2012 WO
2012122294 Sep 2012 WO
2012129197 Sep 2012 WO
2012135764 Oct 2012 WO
2013006669 Jan 2013 WO
2013023096 Feb 2013 WO
2013025876 Feb 2013 WO
2013043850 Mar 2013 WO
2013062903 May 2013 WO
2013082184 Jun 2013 WO
2013149611 Oct 2013 WO
2013158294 Oct 2013 WO
2013173767 Nov 2013 WO
2013184946 Dec 2013 WO
2014014610 Jan 2014 WO
2014018098 Jan 2014 WO
2014026007 Feb 2014 WO
2014035962 Mar 2014 WO
2014088521 Jun 2014 WO
2014116891 Jul 2014 WO
2014144696 Sep 2014 WO
2015048997 Apr 2015 WO
2016069796 May 2016 WO
2016127139 Aug 2016 WO
Non-Patent Literature Citations (84)
Entry
Fuchs, “The use of an interspinous implant in conjuction with a graded facetectomy procedure”, Spine vol. 30, No. 11, pp. 1266-1272, 2005.
Zucherman, “A Multicenter, Prospective, Randomized Trial Evaluating the X Stop Interspinous Process Decompression System for the Treatment of Neurogenic Intermittent Claudication”, Spine, vol. 30, No. 12, pp. 1351-1358, 2005.
Talwar “Insertion loads of the X STOP interspinous process distraction system designed to treat neurogenic intermittent claudication”, Eur Spine J. (2006) 15: pp. 908-912.
Spine Solutions Brochure—Prodisc 2001, 16 pages.
Siddiqui, “The Positional Magnetic Resonance Imaging Changes in the Lumbar Spine Following Insertion of a Novel Interspinous Process Distraction Device”, Spine, vol. 30, No. 23, pp. 2677-2682, 2005.
Shin, “Posterior Lumbar Interbody Fusion via a Unilateral Approach”, Yonsei Medical Journal, 2006, pp. 319-325, vol. 47(3).
ProMap TM EMG Navigation Probe. Technical Brochure Spineology Inc, Dated May 2009.
Polikeit, “The Importance of the Endplate for Interbody Cages in the Lumbar Spine”, Eur. Spine J., 2003, pp. 556-561, vol. 12.
Niosi, “Biomechanical Characterization of the three-dimentional kinematic behavior of the dynesys dynamic stabilization system: an in vitro study”, Eur Spine J. (2006), 15: pp. 913-922.
Morgenstern, “Transforaminal Endoscopic Stenosis Surgery—A Comparative Study of Laser and Reamed Foraminoplasty”, in European Musculoskeletal Review, Issue 1, 2009.
Medco Forum, “Percutaneous Lumbar Fixation via PERPOS System From Interventional Spine”, Oct. 2007, vol. 14, No. 49.
Medco Forum, “Percutaneous Lumbar Fixation Via PERPOS PLS System Interventional Spine”, Sep. 2008, vol. 15, No. 37.
Mahar et al., “Biomechanical Comparison of Novel Percutaneous Transfacet Device and a Traditional Posterior System for Single Level Fusion”, Journal of Spinal Disorders & Techniques, Dec. 2006, vol. 19, No. 8, pp. 591-594.
Link Sb Charite Brochure—Intervertebral Prosthesis 1988, 29 pages.
Krbec, “Replacement of the Vertebral Body with an Expansion Implant (Synex)”, Acta Chir Orthop Traumatol Cech, 2002, pp. 158-162, vol. 69(3).
King., “Internal Fixation for Lumbosacral Fusion”, The Journal of Bone and Joint Surgery, J. Bone Joint Surg. Am., 1948; 30: 560-578.
Kambin et al., “Percutaneous Lateral Discectomy of the Lumbar Spine: A Preliminary Report”, Clin. Orthop,: 1983, 174: 127-132.
Iprenburg et al., “Transforaminal Endocopic Surgery in Lumbar Disc Hermiation in an Economic crises—The Tessys Method”, US Musculoskeletal, 2008, pp. 47-49.
Hunt, “Expandable Cage Placement Via a Posterolateral Approach in Lumbar Spine Reconstructions”, Journal of Neurosurgery: Spine, Sep. 2006, pp. 271-274, vol. 5.
Hoogland et al., “Total Lumar Intervertebral Disc Replacement: Testing a New Articulating Space in Human Cadaver Spines-24 1”, Annual ORS, Dallas, TX, Feb. 21-23, 1978, 8 pages.
Gray's Anatomy, Crown Publishers, Inc., 1977, pp. 33-54.
Gore, “Technique of Cervical Interbody Fusion”, Clinical Orthopaedics and Related Research, Sep. 1984, pp. 191-195, No. 188.
Folman, Posterior Lumbar Interbody Fusion for Degenerative Disc Disease Using a Minimally Invasive B-Twin Expandable Spinal Spacer, Journal of Spinal Disorders & Techniques, 2003, pp. 455-460, vol. 16(5).
Chin, “Early Results of the Triage Medical Percutaneous Transfacet Pedicular BONE-LOK Compression Device for Lumbar Fusion”, Accessed online Jul. 10, 2017, 10 pages.
Chiang, “Biomechanical Comparison of Instrumented Posterior Lumbar Interbody Fusion with One or Two Cages by Finite Element Analysis”, Spine, Sep. 2006, pp. E682-E689, vol. 31(19), Lippincott Williams & Wilkins, Inc.
Brooks et al., “Efficacy of Supplemental Posterior Transfacet Pedicle Device Fixation in the Setting of One- or Two-Level Anterior Lumbar Interbody Fusion”, Retrieved Jun. 19, 2017, 6 pages.
Brochure for PERPOS PLS System Surgical Technique by Interventional Spine, 2008, 8 pages.
Alfen et al., “Developments in the area of Endoscopic Spine Surgery”, European Musculoskeletal Review 2006, pp. 23-24, ThessysTM, Transforaminal Endoscopic Spine Systems, joi max Medical Solutions.
International Patent Application No. PCT/US2013/029014, International Search Report dated Jul. 1, 2013, 2 pages.
Bruder et al., Identification and characterization of a cell surface differentiation antigen on human osteoprogenitor cells. 42nd Annual Meeting of the Orthopaedic Research Society. p. 574, Feb. 19-22, 1996, Atlanta, Georgia.
Bruder et al., Monoclonal antibodies reactive with human osteogenic cell surface antigens. Bone. Sep. 1997;21 (3):225-235.
Burkoth et al., A review of photocrosslinked polyanhydrides: in situ forming degradable networks. Biomaterials. Dec. 2000; 21 (23): 2395-2404.
Cambridge Scientific News, FDA Approves Cambridge Scientific, Inc.'s Orthopedic WISORB (TM) Malleolar Screw [online], Jul. 30, 2002 [retrieved on Oct. 14, 2003]. Retrieved from the Internet <URL: http://www.cambridgescientificinc.com>.
Carrino, John A., Roxanne Chan and Alexander R. Vaccaro, “Vertebral Augmentation: Vertebroplasty and Kyphoplasty”, Seminars in Roentgenology, vol. 39, No. 1 Jan. 2004: pp. 68-84.
Cheng, B.C., Ph.D., Biomechanical pullout strength and histology of Plasmapore Registered XP coated implants: Ovine multi time point survival study. Aesculap Implant Systems, LLC, 2013, 12 pages.
Edeland, H.G., “Some Additional Suggestions for an Intervertebral Disc Prosthesis”, J of Bio Medical Engr., vol. 7(1) pp. 57-62, Jan. 1985.
European Search Report EP03253921 dated Nov. 13, 2003, 4 pages.
Flemming et al., Monoclonal anitbody against adult marrow-derived mesenchymal stem cells recognizes developing vasculature in embryonic human skin. Developmental Dynamics. 1998;212:119-132.
Ha et al. (Topographical characterization and microstructural interface analysis of vacuum-plasma-sprayed titanium and hydroxyapatite coatings on carbon fiber-reinforced poly(etheretherketone), Journal of Materials Science: Materials in Science 9 (1997), pp. 891-896.
Haas, Norbert P., New Products from AO Development [online], May 2002 [retrieved on Oct. 14, 2003]. Retrieved from the Internet <URL: http://www.ao.asif.ch/development/pdf_tk_news_02.pdf>.
Hao et al., Investigation of nanocomposites based on semi-interpenetrating network of [L-poly (epsilon-caprolactone)]/[net-poly (epsilon-caprolactone)] and hydroxyapatite nanocrystals. Biomaterials. Apr. 2003;24(9): 1531-9.
Harsha et al., Tribo performance of polyaryletherketone composites, Polymer Testing (21) (2002) pp. 697-709.
Haynesworth et al., Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone. 1992;13(1):69-80.
Hitchon et al., Comparison of the biomechanics of hydroxyapatite and polymethylmethacrylate vertebroplasty in a cadaveric spinal compression fracture model. J Neurosurg. Oct. 2001;95(2 Suppl):215-20.
International Patent Application No. PCT /US2013/029014, International Search Report dated Jul. 1, 2013, 7 pages.
Joshi, Ajeya P., M.D. and Paul A. Glazer, M.D., “Vertebroplasty: Current Concepts and Outlook for the Future”, 2003, (5 pp.), From: http://www.orthojournalhms.org/html/pdfs/manuscript-15.pdf.
Kandziora, Frank, et al., “Biomechanical Analysis of Biodegradable Interbody Fusion Cages Augmented with Poly (propylene Glycol-co-Fumaric Acid),” SPINE, 27(15): 1644-1651 (2002).
Kotsias, A., Clinical trial of titanium-coated PEEL cages anterior cervical discectomy and fusion. [Klinishe Untersuching zum Einsatz von titanbeschichteten Polyetheretherketon-Implantaten bei der cervikalen interkorporalen fusion]. Doctoral thesis. Department of Medicine, Charite, University of Medicine Berlin, 2014, 73 pages. (German language document/Engl. summary).
Kroschwitz et al., eds., Hydrogels. Concise Encyclopedia of Polymer Science and Engineering. Wiley and Sons, pp. 458-459, 1990.
Lendlein et al., AB-polymer networks based on oligo(epsilon-caprolactone) segments showing shape-memory properties. Proc Natl Acad Sci US A. Jan. 30, 2001;98(3):842-7. Epub Jan. 23, 2001.
Malberg. M.I., MD; Pimenta, L., MD; Millan, M.M., MD, 9th International Meeting on Advanced Spine Techniques, May 23-25, 2002, Montreux, Switzerland. Paper #54, Paper #60, and E-Poster #54, 5 pages.
McAfee et al., Minimally invasive anterior retroperitoneal approach to the lumbar spine: Emphasis on the lateral BAK. SPINE. 1998;23(13):1476-84.
Mendez et al., Self-curing acrylic formulations containing PMMA/PCL composites: properties and antibiotic release behavior. J Biomed Mater Res. Jul. 2002;61 (1 ):66-74.
Nguyen et al., Poly(Aryl-Ether-Ether-Ketone) and its Advanced Composites: A Review, Polymer Composites, Apr. 1987, vol. 8, No. 2, pp. 57-73.
Osteoset Registered DBM Pellets (Important Medical Information) [online], Nov. 2002 [retrieved on Oct. 14, 2003]. Retrieved from the Internet <URL: http://www.wmt.com/Literature>.
POROCOAT(R) Porous Coating, 1 Page, https://emea.depuysynthese.com/hcp/hip/products/qs/porocoat-porous-coatingemea Accessed on Jul. 31, 2017.
Regan et al., Endoscopic thoracic fusion cage. Atlas of Endoscopic Spine Surgery. Quality Medical Publishing, Inc. 1995;350-354.
Slivka et al., In vitro compression testing of fiber-reinforced, bioabsorbable, porous implants. Synthetic Bioabsorbable Polymers for Implants. STP1396, pp. 124-135, ATSM International, Jul. 2000.
Sonic Accelerated Fracture Healing System/Exogen 3000. Premarket Approval. U.S. Food & Drug Administration. Date believed to be May 10, 2000. Retrieved Jul. 23, 2012 from <http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMA/pma.cfm?id=14736#>. 4 pages, 2012.
Stewart et al., Co-expression of the stro-1 anitgen and alkaline phosphatase in cultures of human bone and marrow cells. ASBMR 18th Annual Meeting. Bath Institute for Rheumatic Diseases, Bath, Avon, UK. Abstract No. P208, p. S142, 1996.
Timmer et al., In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate. Biomaterials. Feb. 2003;24(4 ):571-7.
U.S. Appl. No. 60/424,055, Method and apparatus for spinal fixation, filed Nov. 5, 2002.
U.S. Appl. No. 60/397,588, Method and apparatus for spinal fixation, filed Jul. 19, 2002.
U.S. Appl. No. 61/675,975, Expandable Implant, filed Jul. 26, 2012.
U.S. Appl. No. 60/942,998, Method and Apparatus for Spinal Stabilization, filed Jun. 8, 2007.
United States Disctrict Court, Central District of California, Case No. 1 :10-CV-00849-LPS, Nuvasive, Inc., vs., Globus Medical, Inc., Videotaped Deposition of: Luiz Pimenta, M.D., May 9, 2012, 20 pages.
U.S. Appl. No. 60/794,171, filed Apr. 21, 2006, entitled Method and Apparatus for Spinal Fixation.
Walsh et al., Preparation of porous composite implant materials by in situ polymerization of porous apatite containing epsilon-caprolactone or methyl methacrylate. Biomaterials. Jun. 2001;22( 11):1205-12.
Zimmer.com, Longer BAK/L Sterile Interbody Fusion Devices. Date believed to be 1997. Product Data Sheet.Zimmer. Retrieved Jul. 23, 2012 from <http:/ catalog.zimmer.com/contenUzpc/products/600/600/620/S20/S045. html>, 2 pages.
CN Office Action dated Apr. 24, 2020 for CN Application No. 201780040910.
U.S. Appl. No. 09/558,057, filed Apr. 26, 2000, entitled Bone Fixation System.
US 5,545,827, Oct. 3, 1995, Aust, (withdrawn).
Allcock, “Polyphosphazenes”; The Encyclopedia of Polymer Science; 1988; pp. 31-41; vol. 13; Wiley Intersciences, John Wiley & Sons.
Cohn, “Biodegradable PEO/PLA Block Copolymers”; Journal of Biomedical Materials Research; 1988; pp. 993-1009; vol. 22; John Wiley & Sons, Inc.
Cohn, “Polymer Preprints”; Journal of Biomaterials Research; 1989; p. 498; Biomaterials Research Labortatory, Casali Institute of Applied Chemistry, Israel.
Heller, “Poly (Otrho Esters)”; Handbook of Biodegradable Polymers; edited by Domb; et al; Hardwood Academic Press; 1997; pp. 99-118.
Japanese Office Action for Application No. 2013-542047, dated Sep. 8, 2015 (12 pages).
Japanese Office Action for Application No. 2016-135826, dated Jun. 6, 2017, (7 pages).
Kemnitzer, “Degradable Polymers Derived From the Amino Acid L-Tyrosine”; 1997; pp. 251-272; edited by Domb, et al., Hardwood Academic Press.
Khoo, “Minimally Invasive Correction of Grade I and II Isthmic Spondylolisthesis using AxiaLIF for L5/S1 Fusion”, pp. 1-7, Rev B Sep. 15, 2008.
U.S. Appl. No. 61/009,546, filed Dec. 28, 2007 Rodgers.
U.S. Appl. No. 61/140,926, filed Dec. 26, 2008 Spann.
U.S. Appl. No. 61/178,315, filed May 14, 2009 Spann.
Vandorpe, “Biodegradable Polyphosphazenes for Biomedical Applications”; Handbook of Biodegradable Polymers; 1997; pp. 161-182; Hardwood Academic Press.
Related Publications (1)
Number Date Country
20190142602 A1 May 2019 US
Provisional Applications (1)
Number Date Country
60869088 Dec 2006 US
Continuations (3)
Number Date Country
Parent 13845644 Mar 2013 US
Child 16243188 US
Parent 13334526 Dec 2011 US
Child 13845644 US
Parent 11952900 Dec 2007 US
Child 13334526 US