Intervertebral prosthetic device for spinal stabilization and method of implanting same

Information

  • Patent Grant
  • 7862591
  • Patent Number
    7,862,591
  • Date Filed
    Thursday, November 10, 2005
    19 years ago
  • Date Issued
    Tuesday, January 4, 2011
    13 years ago
Abstract
An intervertebral prosthetic device and method for spinal stabilization, according to which a prosthetic device is implanted relative to two vertebrae and is positioned so that it makes a rigid connection with one of the vertebra and a non-rigid connection with the other vertebra.
Description
BACKGROUND

The present invention relates to an intervertebral prosthetic device for stabilizing the human spine, and a method of implanting same.


Spinal discs that extend between adjacent vertebrae in vertebral columns of the human body provide critical support between the adjacent vertebrae. These discs can rupture, degenerate, and/or protrude by injury, degradation, disease, or the like to such a degree that the intervertebral space between adjacent vertebrae collapses as the disc loses at least a part of its support function, which can cause impingement of the nerve roots and severe pain.


In these cases, intervertebral prosthetic devices have been designed that can be implanted between the adjacent vertebrae, both anterior and posterior of the column and are supported by the respective spinous processes of the vertebrae to prevent the collapse of the intervertebral space between the adjacent vertebrae and provide motion stabilization of the spine. Many of these devices are supported between the spinous processes of the adjacent vertebrae.


In some situations it is often necessary to perform a laminectomy to remove the laninae and the spinous process from at least one vertebra to remove a intervertebral disc and/or to decompress a nerve root. Typically, in these procedures, two vertebral segments are fused together to stop any motion between the segments and thus relieve the pain. However, since the spinous process is removed from one of the vertebra, it would be impossible to implant a intervertebral prosthetic device of the above type since the device requires support from both spinous processes of adjacent vertebrae.


SUMMARY

According to an embodiment of the invention an intervertebral prosthetic device is provided that is implantable between two adjacent vertebrae, at least one of which is void of a spinous process, to provide motion stabilization.


Various embodiments of the invention may possess one or more of the above features and advantages, or provide one or more solutions to the above problems existing in the prior art.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 is a side elevational view of an adult human vertebral column.



FIG. 2 is a posterior elevational view of the column of FIG. 1.



FIG. 3 is an enlarged, front elevational view of one of the vertebra of the column of FIGS. 1 and 2.



FIG. 4 is an isometric view of a portion of the column of FIGS. 1 and 2, depicting an intervertebral prosthetic device according to an embodiment of the invention inserted between two adjacent vertebrae.



FIG. 5 is an enlarged, isometric view of the prosthetic device of FIG. 4.



FIG. 6 is an enlarged, sectional view depicting the implanted prosthetic device of FIGS. 4 and 5.



FIG. 7 is a view similar to that of FIG. 5, but depicting an alternate embodiment of the invention.



FIG. 8 is a view similar to that of FIG. 7, but depicting an alternate embodiment of the invention using multiaxial screws.



FIG. 9 is a view similar to FIG. 4, but depicting an alternate embodiment of the invention.





DETAILED DESCRIPTION

With reference to FIGS. 1 and 2, the reference numeral 10 refers, in general, to a human vertebral column 10. The lower portion of the vertebral column 10 is shown and includes the lumbar region 12, the sacrum 14, and the coccyx 16. The flexible, soft portion of the vertebral column 10, which includes the thoracic region and the cervical region, is not shown.


The lumbar region 12 of the vertebral column 10 includes five vertebrae V1, V2, V3, V4 and V5 separated by intervertebral discs D1, D2, D3, and D4, with the disc D1 extending between the vertebrae V1 and V2, the disc D2 extending between the vertebrae V2 and V3, the disc D3 extending between the vertebrae V3 and V4, and the disc D4 extending between the vertebrae V4 and V5.


The sacrum 14 includes five fused vertebrae, one of which is a superior vertebra V6 separated from the vertebra V5 by a disc D5. The other four fused vertebrae of the sacurm 14 are referred to collectively as V7. A disc D6 separates the sacrum 14 from the coccyx 16 which includes four fused vertebrae (not referenced).


With reference to FIG. 3, the vertebra V5 includes two laminae 20a and 20b extending to either side (as viewed in FIG. 2) of a spinous process 22 that projects posteriorly from the juncture of the two laminae. Two transverse processes 24a and 24b extend laterally from the laminae 20a and 20b, respectively, and two pedicles 26a and 26b extend inferiorly from the processes 24a and 24b to a vertebral body 28. Since the other vertebrae V1-V3 are similar to the vertebra V5 they will not be described in detail.


As better shown in FIG. 4, the vertebra V4 is similar to the vertebra V5 with the exception that a laminectomy has been performed to remove the laminae 20a and 20b as well as the spinous process 22 from the vertebra V4 for the reasons set forth above.


An intervertebral disc prosthetic device 30 according to an embodiment of the invention is provided for implanted relative to the vertebrae V4 and V5. The device 30 is shown in detail in FIG. 5 and includes a body member 32 which is substantially rectangular in shape with the exception that the upper end 32a of the body member, as viewed in FIG. 5, as well as the two sides 32b and 32c, are curved inwardly to form concave surfaces. A curved saddle, or notch, 32d is formed in the other end portion of the body member 32. The notch 32d forms a concave surface having two opposing lobes, each having a centerline 33a, 33b that extends along the length of the lobe. The centerlines 33a, 33b of the lobes extend in diverging directions. Two through openings 32e and 32f are formed through the body member 32 at the upper corners thereof. Two sleeves 36 are adapted to fit into the openings 32e and 32f, respectively, to strengthen the opening, and two tethers 34a and 34b can be connected at one end to the body member 32 and can be tied to the vertebrae V4 and/or V5 in a conventional manner. Since the tethers 36a and 36b are optional, they are shown in phantom lines. As shown in FIGS. 4-5, a first theoretical axis 33c extends through the centers of the openings 32eand 32f. A second theoretical axis 33d extends substantially normal to the first axis 33cand bisects a distance between the pair of openings 32e, 32f and extends through the notch 32d. In addition, a third theoretical axis 33e extends from the posterior surface to the anterior surface of the body member 32, while the pair of openings 32e and 32fextend along fourth and fifth theoretical axes 33f and 33g respectively. The third theoretical axis 33e extends approximately parallel to the fourth and fifth theoretical axes 33f and 33g.


When the device 30 is implanted relative to the vertebrae V4 and V5 as shown in FIGS. 4 and 6, the device is positioned so that the spinous process 22 of the vertebra V5 extends in the notch 32d. The body member 32 is sized so that, in this position, the openings 32e and 32fextend over the pedicles 26a and 26b of the vertebra V4. Then, two screws 38, one of which is shown in FIG. 6, are inserted through the sleeves 36 in the openings 32e and 32f, respectively (FIG. 5), of the body member 32 and torque is applied to the screws so that they are driven into the respective pedicles 26a and 26b of the vertebrae V4 and V5 to provide compressional and torsional resistance. The screws 38 can be of any conventional type and therefore will not be described in detail.


Thus, the device 30 is connected to the vertebra V5 by a non-rigid connection provided by the notch 32d, and to the vertebra V4 by a rigid connection provided by the screws 38, notwithstanding the fact that the spinous process of the vertebra V4 is missing. The tethers 34aand 34b can also be tied to the vertebrae V4 and/or V5 to provide additional distracting resistance.


The materials making up the body member 32 can vary within the scope of the invention. For example the body member 32 can be fabricated from a relatively soft material and/or a relatively hard material, or both. In the last case, a relatively soft outer layer, such as silicone, could be molded around a relatively stiff inner layer, such as hard rubber or plastic.


A prosthetic device according to an alternate embodiment is shown, in general, by the reference numeral 40 in FIG. 7. The device 40 includes a body member 42 having a saddle, or curved notch 42a formed in one end thereof which is the lower end as viewed in FIG. 7. Two arms 44a and 44b extend from the other end of the body member 42 and at an angle to the vertical so that their distal ends extend over the pedicles 26a and 26b (FIGS. 3 and 4) of the vertebra V4. Two retaining rings 46a and 46b are mounted to the distal ends of the arms 44a and 44b, respectively, in any conventional manner, and are adapted to receive two screws 48a and 48b, respectively. The retaining rings 46a and 46b, as well as the screws 48a and 48 can be of any conventional type and therefore will not be described in detail.


The device 40 is implanted relative to the vertebrae V4 and V5, so that the spinous process 22 of the vertebra V5 extends in the notch 42a of the body member 42. The screws 48a and 48b are inserted through the rings 46a and 46b, respectively, and torque is applied to the screws so that they are driven into the pedicles 26a and 26b (FIG. 3) of the vertebra V4 which provides compressional and torsional resistance.


Thus, the device 40 is secured in its implanted position by both a non-rigid connection to the vertebra V5 provided by the notch 42a, and a rigid connection to the vertebra V4 provided by the screws 48a and 48b, notwithstanding the fact that the spinous process from the vertebra V4 is missing.


It is understood that the tethers 36a and 36b of the embodiment of FIGS. 5 and 6 can also be connected to the body member 42 and tied to the vertebrae V4 and/or V5 to provide additional distracting resistance.


A prosthetic device according to an alternate embodiment is shown, in general, by the reference numeral 50 in FIG. 8, and includes several components of the embodiment of FIG. 7 which components are given the same reference numerals. As in the previous embodiment, it will be assumed that a laminectomy has been performed to remove the laminae 20a and 20b (FIG. 3) and the spinous process 22 from the vertebra V4 for the reasons set forth above. The device 50 includes the body member 42 of the embodiment of FIG. 7 that has a saddle, or curved notch, 42a formed in one end thereof which is the lower end as viewed in FIG. 8. The two arms 44a and 44b of the embodiment of FIG. 7 are also provided and extend from the other end of the body member 42 and, preferably at an angle to the vertical so that their distal ends extend over the pedicles 26a and 26b (FIGS. 3 and 4) of the vertebra V4.


Two U-shaped clamps 52a and 52b are clamped around the distal end portions of the arms 44a and 44b, respectively. Each clamp 52a and 52b can be designed so that its two legs have spring tension permitting the distal end portions of the arms 44a and 44b to be clamped between the legs. It is understood that, if necessary, fasteners, or the like, can be used to secure the connections.


Two multiaxial screws 54a and 54b are supported in the bases of the clamps 52a and 52b respectively, in a conventional manner, so that the screws can be pivoted relative to the clamps to change the angular positions of the screws. Examples of two positions that the screws 54a and 54b can take are shown in FIG. 8 by the solid lines and the phantom lines, respectively, it being understood that the screws can take numerous other positions.


The device 50 is implanted relative to the vertebrae V4 and V5, so that the spinous process 22 of the vertebra V5 extends in the notch 42a of the body member 42. The screws 54a and 54b are placed at the proper angle relative to the pedicles 26a and 26b (FIG. 3) of the vertebra V4, and torque is applied to the screws so that they are driven into the pedicles to provide compressional and torsional resistance.


Thus, the device 50 is secured in its implanted position by both a non-rigid connection to the vertebra V5 provided by the notch 42a, and a rigid connection to the vertebra V4 provided by the screws 54a and 54b, notwithstanding the fact that the spinous process from the vertebra V4 is missing.


It is understood that the tethers 36a and 36b of the embodiment of FIGS. 5 and 6 can also be connected to the body member 42 of each of the above embodiment and tied to the vertebrae V4 and/or V5 to provide additional distracting resistance.


A device according to another alternate embodiment is shown, in general by the reference numeral 60 in FIG. 9. In the figure, the spinous process 22 from vertebra V4 has been removed. A complete laminectomy as described in previous embodiments could be performed at the V4 level as well.


The device 60 is designed to be used with two constructs 62a and 62b that extend between, and to the sides of, the location of the above laminectomy. It is understood that, in most circumstances, the constructs 62a and 62b would have been implanted in this manner in a previous procedure for the purpose of providing immobilization and/or stabilization to the spinal system, and/or to serve as an adjunct to fusion of one or more portions of the spinal system.


The construct 62a consists of a rod 64a having a pair of spaced mounting rings 66a and 66b connected to the rod near its respective ends. The mounting rings 66a and 66b receive pedicle screws 68a and 68b, respectively that are threadably engaged with the pedicle 20b (FIG. 3) on one side of the vertebra V4 and the corresponding pedicle on the vertebra V5. Since the construct 62b is identical to the construct 62a, it will not be described in detail, it being understood that its pedicle screws are threadably engaged with the pedicle 20a (FIG. 3) on the other side of the vertebra V4 and the corresponding pedicle of the vertebra V5, respectively


The device 60 includes the body member 42 of the embodiment of FIG. 7 that has a saddle, or curved notch 42a formed in one end thereof which is the upper end as viewed in FIG. 9. Two arms 70a and 70b extend from the other end of the body member 42 and, preferably at an angle to the vertical, and two U-shaped clamps 72a and 72b are affixed near the distal ends of the arms 70a and 70b, respectively. The clamp 72a is adapted to clamp over the arm 64a of the construct 62a, and the clamp 72b is adapted to clamp over the corresponding arm of the construct 62b. Since the clamps 72a and 72b are conventional, they will not be described in detail.


The device 60 is implanted relative to the vertebrae V3 and V5, so that the spinous process 22 of the vertebra V3 extends in the notch 42a of the body member 42. The arms 70a and 70b are adjusted as necessary so that the clamp 72a extends over the rod 64a of the construct 62a between the mounting rings 66a and 66b; and the clamp 72b extends over the rod of the construct 62b between its respective mounting rings. The clamps 72a and 72b are then clamped to the rod 64a and the rod of the construct 62b to secure the member 42 to the constructs 62a and 62b.


Thus, the device 60 is secured in its implanted position by both a non-rigid connection to the vertebra V3 provided by the notch 42a in the member 42, and a rigid connection to the vertebrae V4 and V54 provided by the above connection of the device 60 to the construct 62.


It is understood that the lengths of the rods 64a and 64b can be greater than that shown and discussed in the example above in which case additional mounting rings, identical to the rings 66a and 66b, would also be connected to the rods. Also, the pedicle screw 66a, and the corresponding screw associated with the construct 62b, can be located so that they extend in the pedicles of the vertebra V3 as described above or in the pedicles of the vertebra V4; while the pedicle screw 66b, and the corresponding screw associated with the construct 62b, can be located so that they extend in the pedicles of the vertebra V4 as described above or in the pedicles of the vertebra V5.


Additionally, it is understood that the arms 70a and 70b could be long enough such that the embodiment could be mounted to a construct 62a or 62b while the member 42 could rest against a non-adjacent spinous process 22. For example, the member 42 could be nested against the spinous process 22 of VI with the construct 62a or 62b anchored between V4 and V5.


In each of the above embodiments, the materials making up the body member 42 can vary within the scope of the invention. For example, the body member 42 can be fabricated from a relatively hard material and/or a relatively soft material, or both. In the last case, a relatively soft outer layer such as silicone, could be molded around a relatively stiff inner layer, such as hard rubber or plastic.


Variations

It is understood that variations may be made in the foregoing without departing from the invention and examples of some variations are as follows:

    • The above non-rigid connection can be to one of the vertebrae V3, V4 or V5, and the rigid connection to another.
    • The body member 32 can be provided with additional openings to receive additional screws that could be driven in the vertebrae V4 and/or V5.
    • The body members 32 and 42 can vary in shape, size, composition, and physical properties.
    • The surfaces of the body member defining the notch 32d can be treated, such as by providing teeth, ridges, knurling, etc., to better grip the spinous process.
    • The body members 32 and 42 can be fabricated of a permanently deformable material thus providing a clamping action against the spinous process.
    • Any conventional substance that promotes bone growth, such as HA coating, BMP, or the like, can be incorporated in the prosthetic device of each of the above embodiments.
    • The body members 32 and 42 can have through holes formed therein to improve integration of the bone growth.
    • The devices 30, 40, 50 and 60 can be implanted relative to two vertebrae in the vertebral column 10 other than the vertebrae V4 and V5.
    • Bilateral extrusions, or the like, can be provided on one or more of the body members 32 and 42 to enable a tether to be attached to the body member.
    • The prostheses of the above embodiments can be inserted between two vertebrae following a discectemy in which a disc between the adjacent vertebrae is removed, or corpectomy in which at least one vertebra is removed.
    • The screws 36, 48a, 48b, 54a, 54b, 68a. and 68b can extend into areas of the vertebra V4 other than the pedicles 26a and 26b. For example, the pedicle screw 68a of the construct 62a, and the corresponding screw of the construct 62b, can engage the vertebra V3 rather than the vertebra V4; and the pedicle screw 68b of the construct 62a, and the corresponding screw of the construct 62b can engage the vertebra V4 rather than the vertebra V5.
    • The spatial references made above, such as “under”, “over”, “between”, “upper”, “lower”, “top”, “bottom”, “side”, etc. are for the purpose of illustration only and do not limit the specific orientation or location of the structure described above.


The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, therefore, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the invention or the scope of the appended claims, as detailed above. In the claims, means-plus-function clauses are intended to cover the structures described herein as performing the recited function and not only structural equivalents but also equivalent structures. Thus, although a nail and a screw may not be structural equivalents in that a nail employs a cylindrical surface to secure wooden parts together, whereas a screw employs a helical surface, in the environment of fastening wooden parts, a nail and a screw are equivalent structures.

Claims
  • 1. A prosthetic device, comprising: a monolithic body member comprising: a concave upper surface;a pair of opposing concave side surfaces;a concave lower surface opposite the concave upper surface, the concave lower surface defining a notch sized for non-rigidly receiving a spinous process of a first vertebra; the concave lower surface having two opposing lobes;an upper portion of the body member, disposed proximate the concave upper surface and having a pair of through openings extending therethrough, each of the through openings positioned adjacent an upper corner of the body member such that when the spinous process of the first vertebra is received within the notch defined by concave lower surface the pair of through openings are substantially aligned with an adjacent second vertebra such that bone anchors may be inserted through the through openings to rigidly secure the body member to the second vertebra;a lower portion of the body member, disposed proximate the notch, being devoid of through openings;wherein a first theoretical axis extends through centers of the pair of through openings;wherein a second theoretical axis extending substantially normal to the first theoretical axis bisects a distance between the pair of through openings into two equal lengths and extends through the notch;wherein each of the two opposing lobes includes a centerline that extends in a direction from a base to a tip of the lobe; wherein the base of each lobe is disposed more proximate to the through openings and the tip of each lobe is disposed more distal to the through openings; the centerlines of two opposing lobes extending in diverging directions.
  • 2. The prosthetic device of claim 1, further comprising a pair of sleeves positioned within the through openings.
  • 3. The prosthetic device of claim 1, further comprising a pair of tethers connected to the body member.
  • 4. The prosthetic device of claim 1, wherein the body member has an upper width adjacent the upper surface and a lower width adjacent the lower surface, the upper width being greater than the lower width.
  • 5. The prosthetic device of claim 4, wherein the body member is formed substantially of a relatively soft material.
  • 6. The prosthetic device of claim 4, wherein the body member is formed substantially of a relatively rigid material.
  • 7. The prosthetic device of claim 4, wherein the body member comprises an inner portion formed of a first material and an outer portion formed of a second material, wherein the first material is more rigid than the second material.
  • 8. The prosthetic device of claim 4, wherein the body member comprises a substantially uniform thickness.
  • 9. The prosthetic device of claim 1 wherein the body member further comprises a posterior surface and an anterior surface spaced from each other and disposed generally transverse to the upper surface, the lower surface, and the side surfaces; wherein the notch extends from the posterior surface to the anterior surface.
  • 10. The prosthetic device of claim 9 wherein the pair of through openings extend from the posterior surface to the anterior surface and are oriented generally parallel to the notch.
  • 11. The prosthetic device of claim 9 wherein, when the notch receives the first vertebra: the notch is configured to intersect a sagittal plane defined by the first and second vertebra; andthe pair of through openings are configured to extend substantially parallel to the sagittal plane.
  • 12. The prosthetic device of claim 9 wherein: the notch extends along a third theoretical axis extending from the posterior surface to the anterior surface of the body member; andthe pair of through openings extend along fourth and fifth theoretical axes respectively, the fourth and fifth theoretical axes extending approximately parallel to the third theoretical axis.
  • 13. The prosthetic device of claim 1 wherein: the body member comprises first and second pairs of outwardly extending lobes;the pair of through openings associated with the first pair of lobes;the second pair of lobes disposed proximate the notch.
  • 14. The prosthetic device of claim 13 wherein said second pair of lobes are spaced farther apart than said first pair of lobes.
  • 15. The prosthetic device of claim 9 wherein the body member has a substantially uniform thickness from the posterior surface to the anterior surface from a first of the side surfaces to the other of the side surfaces.
  • 16. A prosthetic device, comprising: a monolithic body member comprising at least one concave surface defining a notch sized for non-rigidly receiving a spinous process of a first human vertebra;a pair of through openings extending through the body member; each of the through openings positioned on the body member such that when the spinous process of the first vertebra is received within the notch defined by the concave surface, the pair of through openings are substantially aligned with an adjacent second vertebra such that bone anchors may be inserted through the through openings to rigidly secure the body member to the second vertebra;wherein the body member comprises first and second pairs of outwardly extending lobes; the first pair of lobes is associated with the through openings and the second pair of lobes is disposed proximate the notch and is devoid of through openings;wherein a first theoretical axis extends through centers of the pair of through openings;wherein a second theoretical axis extending substantially normal to the first theoretical axis bisects a distance between the pair of through openings into two equal lengths and extends through the notch;wherein each lobe of the second pair of lobes includes a centerline that extends in a direction from a base to a tip of the lobe;wherein the base of each of the second pair of lobes is disposed more proximate to the through openings and the tip of each of the second pair of lobes is disposed more distal to the through openings; the centerlines of the second pair of lobes extending in diverging directions.
  • 17. The prosthetic device of claim 16 wherein said first pair of lobes are spaced farther apart than said second pair of lobes.
US Referenced Citations (189)
Number Name Date Kind
2677369 Knowles May 1954 A
3648691 Lumb et al. Mar 1972 A
4011602 Rybicki et al. Mar 1977 A
4257409 Bacal et al. Mar 1981 A
4554914 Kapp et al. Nov 1985 A
4573454 Hoffman Mar 1986 A
4604995 Stephens et al. Aug 1986 A
4686970 Dove et al. Aug 1987 A
4827918 Olerud May 1989 A
5011484 Breard Apr 1991 A
5047055 Bao et al. Sep 1991 A
5092866 Breard et al. Mar 1992 A
5201734 Cozad et al. Apr 1993 A
5306275 Bryan Apr 1994 A
5306308 Gross et al. Apr 1994 A
5360430 Lin Nov 1994 A
5366455 Dove Nov 1994 A
5415661 Holmes May 1995 A
5437672 Alleyne Aug 1995 A
5454812 Lin Oct 1995 A
5496318 Howland et al. Mar 1996 A
5609634 Voydeville Mar 1997 A
5628756 Barker, Jr. et al. May 1997 A
5634926 Jobe Jun 1997 A
5645599 Samani Jul 1997 A
5674295 Ray et al. Oct 1997 A
5676702 Ratron Oct 1997 A
5690649 Li Nov 1997 A
5702452 Argenson et al. Dec 1997 A
5755798 Papavero et al. May 1998 A
5800547 Schäfer et al. Sep 1998 A
5810815 Morales Sep 1998 A
5836948 Zucherman et al. Nov 1998 A
5860977 Zucherman et al. Jan 1999 A
5976186 Bao et al. Nov 1999 A
6022376 Assell et al. Feb 2000 A
6048342 Zucherman et al. Apr 2000 A
6059829 Schläpfer et al. May 2000 A
6068630 Zucherman et al. May 2000 A
6113638 Williams et al. Sep 2000 A
6132464 Martin Oct 2000 A
6143031 Knothe et al. Nov 2000 A
6143032 Schafer et al. Nov 2000 A
6143033 Paul et al. Nov 2000 A
6179873 Zientek Jan 2001 B1
6224631 Kohrs May 2001 B1
6277149 Boyle et al. Aug 2001 B1
6293949 Justis et al. Sep 2001 B1
6325827 Lin Dec 2001 B1
6352537 Strnad Mar 2002 B1
6364883 Santilli Apr 2002 B1
6383221 Scarborough et al. May 2002 B1
6402750 Atkinson et al. Jun 2002 B1
6419703 Fallin et al. Jul 2002 B1
6440169 Elberg et al. Aug 2002 B1
6451019 Zucherman et al. Sep 2002 B1
6500178 Zucherman et al. Dec 2002 B2
6503279 Webb et al. Jan 2003 B1
6514256 Zucherman et al. Feb 2003 B2
6530955 Boyle et al. Mar 2003 B2
6547823 Scarborough et al. Apr 2003 B2
6582433 Yun Jun 2003 B2
6610091 Reiley Aug 2003 B1
6613090 Fuss et al. Sep 2003 B2
6626944 Taylor Sep 2003 B1
6645207 Dixon et al. Nov 2003 B2
6645208 Apfelbaum et al. Nov 2003 B2
6663632 Frigg Dec 2003 B1
6695842 Zucherman et al. Feb 2004 B2
6706067 Shimp et al. Mar 2004 B2
6709435 Lin Mar 2004 B2
6723126 Berry Apr 2004 B1
6733534 Sherman May 2004 B2
6761720 Senegas Jul 2004 B1
6835205 Atkinson et al. Dec 2004 B2
6843805 Webb et al. Jan 2005 B2
6946000 Senegas et al. Sep 2005 B2
6974478 Reiley et al. Dec 2005 B2
7041136 Goble et al. May 2006 B2
7048736 Robinson et al. May 2006 B2
7087083 Pasquet et al. Aug 2006 B2
7101375 Zucherman et al. Sep 2006 B2
7163558 Senegas et al. Jan 2007 B2
7186254 Dinh et al. Mar 2007 B2
7201751 Zucherman et al. Apr 2007 B2
7238204 Le Couedic et al. Jul 2007 B2
7306628 Zucherman et al. Dec 2007 B2
7335203 Winslow et al. Feb 2008 B2
7377942 Berry May 2008 B2
7442208 Mathieu et al. Oct 2008 B2
7445637 Taylor Nov 2008 B2
20010012938 Zucherman et al. Aug 2001 A1
20010016743 Zucherman et al. Aug 2001 A1
20020128654 Steger et al. Sep 2002 A1
20020143331 Zucherman et al. Oct 2002 A1
20030028250 Reiley et al. Feb 2003 A1
20030045940 Eberlein et al. Mar 2003 A1
20030065330 Zucherman et al. Apr 2003 A1
20030153915 Nekozuka et al. Aug 2003 A1
20040097931 Mitchell May 2004 A1
20040199255 Mathieu et al. Oct 2004 A1
20050010293 Zucherman et al. Jan 2005 A1
20050049708 Atkinson et al. Mar 2005 A1
20050149021 Tozzi Jul 2005 A1
20050165398 Reiley Jul 2005 A1
20050203512 Hawkins et al. Sep 2005 A1
20050203624 Serhan et al. Sep 2005 A1
20050228391 Levy et al. Oct 2005 A1
20050261768 Trieu Nov 2005 A1
20050288672 Feree Dec 2005 A1
20060004447 Mastrorio et al. Jan 2006 A1
20060015181 Elberg Jan 2006 A1
20060064165 Zucherman et al. Mar 2006 A1
20060084983 Kim Apr 2006 A1
20060084985 Kim Apr 2006 A1
20060084987 Kim Apr 2006 A1
20060084988 Kim Apr 2006 A1
20060085069 Kim Apr 2006 A1
20060085070 Kim Apr 2006 A1
20060085074 Raiszadeh Apr 2006 A1
20060089654 Lins et al. Apr 2006 A1
20060089719 Trieu Apr 2006 A1
20060106381 Ferree et al. May 2006 A1
20060106397 Lins May 2006 A1
20060111728 Abdou May 2006 A1
20060122620 Kim Jun 2006 A1
20060129239 Kwak Jun 2006 A1
20060136060 Taylor Jun 2006 A1
20060184247 Edidin et al. Aug 2006 A1
20060184248 Edidin et al. Aug 2006 A1
20060195102 Malandain Aug 2006 A1
20060217726 Maxy et al. Sep 2006 A1
20060224159 Anderson Oct 2006 A1
20060235387 Peterman Oct 2006 A1
20060235532 Meunier et al. Oct 2006 A1
20060241613 Bruneau et al. Oct 2006 A1
20060241757 Anderson Oct 2006 A1
20060247623 Anderson et al. Nov 2006 A1
20060247640 Blackwell et al. Nov 2006 A1
20060264938 Zucherman et al. Nov 2006 A1
20060271044 Petrini et al. Nov 2006 A1
20060271049 Zucherman et al. Nov 2006 A1
20060293662 Boyer, II et al. Dec 2006 A1
20060293663 Walkenhorst et al. Dec 2006 A1
20070005064 Anderson et al. Jan 2007 A1
20070043362 Malandain et al. Feb 2007 A1
20070100340 Lange et al. May 2007 A1
20070123861 Dewey et al. May 2007 A1
20070162000 Perkins Jul 2007 A1
20070167945 Lange et al. Jul 2007 A1
20070173822 Bruneau et al. Jul 2007 A1
20070173823 Dewey et al. Jul 2007 A1
20070191833 Bruneau et al. Aug 2007 A1
20070191834 Bruneau et al. Aug 2007 A1
20070191837 Trieu Aug 2007 A1
20070198091 Boyer et al. Aug 2007 A1
20070233068 Bruneau et al. Oct 2007 A1
20070233074 Anderson et al. Oct 2007 A1
20070233076 Trieu Oct 2007 A1
20070233081 Pasquet et al. Oct 2007 A1
20070233089 DiPoto et al. Oct 2007 A1
20070250060 Anderson et al. Oct 2007 A1
20070270823 Trieu et al. Nov 2007 A1
20070270824 Lim et al. Nov 2007 A1
20070270825 Carls et al. Nov 2007 A1
20070270826 Trieu et al. Nov 2007 A1
20070270827 Lim et al. Nov 2007 A1
20070270828 Bruneau et al. Nov 2007 A1
20070270829 Carls et al. Nov 2007 A1
20070270834 Bruneau et al. Nov 2007 A1
20070270874 Anderson Nov 2007 A1
20070272259 Allard et al. Nov 2007 A1
20070276368 Trieu et al. Nov 2007 A1
20070276496 Lange et al. Nov 2007 A1
20070276497 Anderson Nov 2007 A1
20080015577 Loeb Jan 2008 A1
20080021460 Bruneau et al. Jan 2008 A1
20080114357 Allard et al. May 2008 A1
20080114358 Anderson et al. May 2008 A1
20080114456 Dewey et al. May 2008 A1
20080147190 Dewey et al. Jun 2008 A1
20080161818 Kloss et al. Jul 2008 A1
20080167685 Allard et al. Jul 2008 A1
20080215097 Ensign et al. Sep 2008 A1
20080281360 Vittur et al. Nov 2008 A1
20080281361 Vittur et al. Nov 2008 A1
20090062915 Kohm et al. Mar 2009 A1
20090105773 Lange et al. Apr 2009 A1
20100121379 Edmond May 2010 A1
Foreign Referenced Citations (38)
Number Date Country
2821678 Nov 1979 DE
0322334 Feb 1992 EP
1138268 Oct 2001 EP
1138268 Oct 2001 EP
1330987 Jul 2003 EP
1854433 Nov 2007 EP
2623085 May 1989 FR
2625097 Jun 1989 FR
2681525 Mar 1993 FR
2700941 Aug 1994 FR
2703239 Oct 1994 FR
2707864 Jan 1995 FR
2717675 Sep 1995 FR
2722087 Jan 1996 FR
2722088 Jan 1996 FR
2724554 Mar 1996 FR
2725892 Apr 1996 FR
2730156 Aug 1996 FR
2775183 Aug 1999 FR
2799948 Apr 2001 FR
2816197 May 2002 FR
2858929 Feb 2005 FR
02-224660 Sep 1990 JP
09-075381 Mar 1997 JP
988281 Jan 1983 SU
1484348 Jul 1989 SU
WO 9426192 Nov 1994 WO
WO 9426195 Nov 1994 WO
WO 9820939 May 1998 WO
02051326 Jul 2002 WO
WO 2004047691 Jun 2004 WO
2005009300 Feb 2005 WO
WO 2005009300 Feb 2005 WO
WO 2005044118 May 2005 WO
WO 2005110258 Nov 2005 WO
WO 2006064356 Jun 2006 WO
WO 2007034516 Mar 2007 WO
WO2007052975 May 2007 WO
Related Publications (1)
Number Date Country
20070123861 A1 May 2007 US