TREA

Intraocular lens delivery devices and methods of use

Follow

Information

  • Patent Grant
  • 10595989
  • Patent Number
    10,595,989
  • Date Filed
    Tuesday, June 27, 2017
    7 years ago
  • Date Issued
    Tuesday, March 24, 2020
    4 years ago
Information
Abstract
Intraocular lens delivery devices and methods of use.
Description
BACKGROUND

Intraocular lens delivery systems have been developed but have several shortcomings. To implant an intraocular lens into an eye, an incision needs to be made in the eye to allow for passage of a delivery device and/or the intraocular lens. In general, it is desirable to make the incision is small as possible to cause the least amount of damage to the eye and shorten the healing process. Depending on the configuration and/or size of the intraocular lens, some intraocular lenses need to be deformed, sometimes controllably, into a smaller delivery profile so they will fit through the incision and into the eye. Delivery devices and/or systems are needed that can controllably deform or alter the configuration or orientation of the intraocular lens for delivery through an incision in an eye.


SUMMARY OF THE DISCLOSURE

One aspect of the disclosure is an intraocular lens delivery system, comprising a delivery device with a port therein adapted to receive a cartridge; and a cartridge adapted to receive an intraocular lens therein, the cartridge having a leading haptic receiving area and a trailing haptic receiving area. The port can be a side port, and the delivery device can further comprise a positioning element to align the cartridge and delivery device at a predetermined position.


In some embodiments the cartridge comprises a channel adapted to be in communication with a channel within the delivery device. The cartridge can include an optic receiving area, and wherein the delivery device channel, the cartridge channel, and the optic receiving area are all in fluid communication.


In some embodiments the delivery device includes a first actuator adapted to load an intraocular lens into a distal loading portion of the delivery device, and a second actuator adapted to control a second delivery element to deploy the intraocular lens from the distal loading portion.


One aspect of the disclosure is a cartridge adapted to receive an intraocular lens therein, comprising a first portion with an optic receiving area, a leading haptic receiving area, and a trailing haptic receiving area; and a second portion coupled to the first portion and adapted to be in open and closed positions relative to the first portion.


In some embodiments the second portion has a complimentary optic portion receiving area, a leading haptic receiving area, and a trailing haptic receiving area. The first portion and second portion can be coupled at a hinge. In some embodiments the leading haptic receiving area is distal to the optic receiving area. In some embodiments the trailing haptic receiving area is disposed to the side of the optic receiving area. In some embodiments the cartridge further comprises a channel in communication with the optic receiving area. The channel can be disposed proximal to the optic receiving area.


One aspect of the disclosure is a delivery device adapted to deliver an intraocular lens, comprising an elongate body with a lumen therein; a plunger disposed within the elongate body and adapted to move axially with respect to the elongate body; and an actuator adapted to prime a fluid delivery assembly and dispense a fluid through a fluid channel within the elongate body.


INCORPORATION BY REFERENCE

All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.





BRIEF DESCRIPTION OF THE DRAWINGS

A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the disclosure are utilized, and the accompanying drawings of which:



FIGS. 1A-1C illustrate an exemplary delivery system including a delivery device and cartridge.



FIGS. 2A-2C illustrate an exemplary cartridge and intraocular lens.



FIGS. 3A-3E illustrate an exemplary method of delivering an intraocular lens using the delivery device and cartridge.





DETAILED DESCRIPTION

One aspect of the disclosure is a delivery system including a delivery device adapted to receive a cartridge therein. The cartridge is adapted to receive an intraocular lens. In use, the delivery system delivers the intraocular lens from the cartridge and the delivery device and into an eye.



FIGS. 1A-1C show an exemplary system including delivery device 10 and cartridge 20 disposed therein. An intraocular lens is not show in the cartridge for clarity, and a variety of intraocular lenses could be used with the systems herein. Delivery device 10 includes elongate body 11 extending between proximal portion 22 and distal portion 16. Elongate body 11 is adapted to receive plunger 12 therein, such that device functions similarly to a syringe. Elongate body 11 includes a port extending therethrough, adapted to receive cartridge 20. Device 10 also includes first actuator 14 and second actuator 18, the latter in the form of a trigger. Distal portion 16 is in the form of a nozzle with a distal port from which the intraocular lens is deployed. In this embodiment the distal port has a beveled end. Distal portion 16 is also tapered towards the distal end. The cross section at the distal end is generally elliptical. FIGS. 1B and 1C show side view and bottom views, respectively, of cartridge 20 disposed within device 10.



FIG. 2A illustrates cartridge 20 in an open configuration and adapted to receive an intraocular lens therein. Cartridge 20 is hinged with a first portion 32 and a second portion 34 coupled by any type of hinge 36 (e.g., a living hinge). Cartridge 20 has been formed with an intraocular lens receiving area, which includes an optic portion receiving area 38, leading haptic receiving area 40, and trailing haptic receiving area 42. In some embodiments the cartridge is molded with these areas formed therein. Cartridge also includes channel 56 disposed proximal to the lens receiving area, adapted to receive a portion of delivery system, a fluid, etc., therethrough.



FIG. 2B shows an exemplary intraocular lens disposed within cartridge 20. In this embodiment, intraocular lens includes an optic portion 50 and haptics 52 and 54. Optic 50 has been positioned within optic receiving area 38, haptic 54 has been positioned within leading haptic receiving area 40, and haptic 52 has been positioned within trailing haptic receiving area 42. Haptic 54 is disposed distal to the optic 50, while haptic 52 is positioned generally to the side of optic 50, but could be disposed in any position relative to the optic. For example, haptic 52 could be positioned in a more trailing position if haptic receiving area 42 were formed in such a position.


In this exemplary embodiment, the intraocular lens is a fluid-driven intraocular lens, such as is described in US 2008/0306588, filed Jul. 22, 2008, now U.S. Pat. No. 8,328,869, the disclosure of which is incorporated by reference herein. Optic portion 50 is in fluid communication with haptics 52 and 54. Fluid distribution during delivery and other methods of use that can be incorporated into the systems herein can be found in US 2009/0030425, filed Jul. 23, 2008, the disclosure of which is incorporated by reference herein.


In FIG. 2C, first portion 32 has been closed relative to second portion 34 such that the cartridge is in a closed position, ready to be positioned within delivery device 10. When portion 32 is closed, some of the fluid within the lens may be slightly redistributed within the lens, or it may not be.



FIG. 3A illustrates cartridge 20 with an intraocular lens disposed therein, and delivery device 10, including port 66 adapted to receive cartridge 20 therethrough. Device 10 also includes positioning element 68 adapted to maintain cartridge 20 at a predetermined position with respect to port 66. The positioning element 68 is positioned to align a channel within device 10 with channel 56 in cartridge 20. This allows a fluid, a portion of delivery device, etc., to be advanced through the delivery device and the cartridge to deploy the intraocular lens, as described below.



FIG. 3B shows cartridge 20 advanced through port 66 (which could also be a top port or bottom port) and engaging positioning element 68.


Actuator 70 is then retracted in the proximal direction (“P”), which activates, or primes, fluid delivery. In FIG. 3D, actuator 18 in the form of a trigger is actuated, causing actuator 70 to be advanced forward, moving a fluid (or mechanical component) through channel 56 in cartridge 20. This causes the intraocular lens to be advanced through cartridge and loaded into the nozzle of device 10. As is it being loaded, the haptics and/or optic are deformed into a delivery configuration. Positioning the haptics as described with respect to FIGS. 2A-2C, the leading haptic is first loaded, followed by the optic, and then by the trailing haptic. This configuration eases the loading on the lens. While actuation of actuator 18 can move a fluid through the system to load the lens, actuating actuator 18 can alternatively or in addition to move a piston or plunger component that engages and pushes the lens into the nozzle. The plunger can be adapted to engage the optic, bypassing the trailing haptic.


In FIG. 3E, plunger 12 is advanced with respect to body 11 and within body 11, causing plunger 80 to be advanced relative to body 11 and to the intraocular lens. This plunger is advanced until it engages with the lens and drives it out of the nozzle and into an eye.


Intraocular lenses with different configurations can be delivered with the cartridges and delivery devices herein, as long as the cartridge is adapted to receive them. For example, the cartridge may need to be molded in a different way to receive a different intraocular lens.


While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure.

Claims
  • 1. A method of loading an intraocular lens, comprising: providing an intraocular lens comprising an optic portion, a trailing haptic, and a leading haptic;providing a delivery device adapted to receive a loading device;providing the loading device comprising an optic portion receiving area and a trailing haptic receiving area, the trailing haptic receiving area extending laterally away from an axis passing through the optic portion receiving area;deforming the trailing haptic from an at-rest configuration when placing the intraocular lens into the loading device so that a segment of the trailing haptic curves circumferentially around the optic portion and a terminal end of the trailing haptic points away from the optic portion; andpositioning the optic portion in the optic portion receiving area and the deformed trailing haptic in the trailing haptic receiving area, wherein the trailing haptic and the leading haptic are simultaneously deformed into delivery configurations when the trailing haptic and the leading haptic are positioned within the loading device prior to the intraocular lens being advanced distally within the loading device.
  • 2. The method of claim 1, further comprising advancing the intraocular lens distally within the loading device, wherein the positioning step occurs prior to advancing the intraocular lens distally.
  • 3. The method of claim 2, wherein advancing the intraocular lens distally comprises advancing a fluid through the loading device.
  • 4. The method of claim 2, wherein advancing the intraocular lens distally comprises advancing a plunger through the loading device.
  • 5. The method of claim 1, further comprising deforming the leading haptic from an at-rest configuration into a delivery configuration such that a terminal end of the leading haptic points away from the optic portion.
  • 6. The method of claim 5, further comprising positioning the leading haptic into a leading haptic receiving area of the loading device.
  • 7. The method of claim 5, wherein the leading haptic is positioned into the leading haptic receiving area prior to positioning the trailing haptic into the trailing haptic receiving area.
  • 8. The method of claim 6, wherein the leading haptic receiving area comprises a tapered portion.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 14/728,824, filed Jun. 2, 2015, which is a continuation of U.S. application Ser. No. 14/163,794, filed Jan. 24, 2014, now U.S. Pat. No. 9,044,317, which is a continuation of U.S. application Ser. No. 13/180,427, filed Jul. 11, 2011, now U.S. Pat. No. 8,668,734, which application claims the benefit of U.S. Provisional Application No. 61/363,155, filed Jul. 9, 2010, all of which are incorporated herein by reference in their entirety.

US Referenced Citations (568)
Number Name Date Kind
4111995 Nelson Sep 1978 A
4251887 Anis Feb 1981 A
4253199 Banko Mar 1981 A
4254509 Tennant Mar 1981 A
4304895 Loshaek Dec 1981 A
4373218 Schachar Feb 1983 A
4409691 Levy Oct 1983 A
4423809 Mazzocco Jan 1984 A
4435855 Pannu Mar 1984 A
4435856 L'Esperance Mar 1984 A
4466705 Michelson Aug 1984 A
4490860 Rainin Jan 1985 A
4494254 Lopez Jan 1985 A
4512040 McClure Apr 1985 A
4528311 Beard et al. Jul 1985 A
4575373 Johnson Mar 1986 A
4585457 Kalb Apr 1986 A
4600004 Lopez et al. Jul 1986 A
4604295 Humphreys Aug 1986 A
4615701 Woods Oct 1986 A
4620954 Singer et al. Nov 1986 A
4681102 Bartell Jul 1987 A
4685921 Peyman Aug 1987 A
4685922 Peyman Aug 1987 A
4693717 Michelson Sep 1987 A
4702244 Mazzocco Oct 1987 A
4720286 Bailey et al. Jan 1988 A
4731078 Stoy et al. Mar 1988 A
4731079 Stoy Mar 1988 A
4731080 Galin Mar 1988 A
4747404 Jampel et al. May 1988 A
4763650 Hauser Aug 1988 A
4764423 Yamaguchi et al. Aug 1988 A
4765329 Cumming et al. Aug 1988 A
4781719 Kelman Nov 1988 A
4784485 Ho Nov 1988 A
4787903 Grendahl Nov 1988 A
4790847 Woods Dec 1988 A
4813956 Gupta Mar 1989 A
4816031 Pfoff Mar 1989 A
4819631 Poley Apr 1989 A
4834094 Patton et al. May 1989 A
4836201 Patton et al. Jun 1989 A
4842601 Smith Jun 1989 A
4848343 Wallsten et al. Jul 1989 A
4862885 Cumming Sep 1989 A
4880000 Holmes et al. Nov 1989 A
4888012 Horn et al. Dec 1989 A
4892543 Turely Jan 1990 A
4902293 Feaster Feb 1990 A
4906247 Fritch Mar 1990 A
4911158 Weatherly Mar 1990 A
4911714 Poley Mar 1990 A
4913536 Barnea Apr 1990 A
4917680 Poley Apr 1990 A
4919130 Stoy et al. Apr 1990 A
4919151 Grubbs et al. Apr 1990 A
4932966 Christie et al. Jun 1990 A
4934363 Smith et al. Jun 1990 A
4946469 Sarfarazi Aug 1990 A
4950289 Krasner Aug 1990 A
4955889 Van Gent Sep 1990 A
4963148 Sulc et al. Oct 1990 A
4988352 Poley Jan 1991 A
4994082 Richards et al. Feb 1991 A
4995879 Dougherty Feb 1991 A
4995880 Galib Feb 1991 A
5007913 Dulebohn et al. Apr 1991 A
5015254 Greite May 1991 A
5026393 Mackool Jun 1991 A
5035710 Nakada et al. Jul 1991 A
5047051 Cumming Sep 1991 A
5061914 Busch et al. Oct 1991 A
5066301 Wiley Nov 1991 A
5078740 Walman Jan 1992 A
5098439 Hill et al. Mar 1992 A
5100410 Dulebohn Mar 1992 A
5123905 Kelman Jun 1992 A
5145884 Yamamoto et al. Sep 1992 A
5145935 Hayashi Sep 1992 A
5152789 Willis Oct 1992 A
5171241 Buboltz et al. Dec 1992 A
5171266 Wiley et al. Dec 1992 A
5176686 Poley Jan 1993 A
5190552 Kelman Mar 1993 A
5200430 Federman Apr 1993 A
5201763 Brady et al. Apr 1993 A
5203788 Wiley Apr 1993 A
5213579 Yamada et al. May 1993 A
5224957 Gasser et al. Jul 1993 A
5235003 Ward et al. Aug 1993 A
5251993 Sigourney Oct 1993 A
5275623 Sarfarazi Jan 1994 A
5275624 Hera et al. Jan 1994 A
5288293 O'Donnell, Jr. Feb 1994 A
5290892 Namdaran et al. Mar 1994 A
5304182 Rheinish et al. Apr 1994 A
5326347 Cumming Jul 1994 A
5354333 Kammann et al. Oct 1994 A
5391590 Gerace et al. Feb 1995 A
5405386 Rheinish et al. Apr 1995 A
5425734 Blake Jun 1995 A
5426166 Usifer et al. Jun 1995 A
5443506 Garabet Aug 1995 A
5444106 Zhou et al. Aug 1995 A
5444135 Cheradame et al. Aug 1995 A
5452932 Griffin Sep 1995 A
5468246 Blake Nov 1995 A
5474562 Orchowski et al. Dec 1995 A
5476514 Cumming Dec 1995 A
5489302 Skottun Feb 1996 A
5494484 Feingold Feb 1996 A
5496328 Nakajima et al. Mar 1996 A
5496366 Cumming Mar 1996 A
5499987 Feingold Mar 1996 A
5506300 Ward et al. Apr 1996 A
5512609 Yang Apr 1996 A
5549614 Tunis Aug 1996 A
5556400 Tunis Sep 1996 A
5562676 Brady et al. Oct 1996 A
5567365 Weinschenk, III et al. Oct 1996 A
5578081 McDonald Nov 1996 A
5582613 Brady et al. Dec 1996 A
5584304 Brady Dec 1996 A
5585049 Grisoni et al. Dec 1996 A
5593436 Langerman Jan 1997 A
5607433 Polla et al. Mar 1997 A
5607472 Thompson Mar 1997 A
5616148 Eagles et al. Apr 1997 A
5620450 Eagles et al. Apr 1997 A
5628795 Langerman May 1997 A
5633504 Collins et al. May 1997 A
5643276 Zaleski Jul 1997 A
5653715 Reich et al. Aug 1997 A
5665822 Bitler et al. Sep 1997 A
5674282 Cumming Oct 1997 A
5676669 Colvard Oct 1997 A
5693095 Freeman et al. Dec 1997 A
5697973 Peyman et al. Dec 1997 A
5702400 Brown et al. Dec 1997 A
5702402 Brady Dec 1997 A
5702441 Zhou Dec 1997 A
5716364 Makker et al. Feb 1998 A
5735858 Makker et al. Apr 1998 A
5766182 McDonald Jun 1998 A
5767669 Hansen et al. Jun 1998 A
5772666 Feingold et al. Jun 1998 A
5774273 Bornhorst Jun 1998 A
5776138 Vidal et al. Jul 1998 A
5776191 Mazzocco Jul 1998 A
5776192 McDonald Jul 1998 A
5800442 Wolf et al. Sep 1998 A
5800533 Eggleston et al. Sep 1998 A
5803925 Yang et al. Sep 1998 A
5810834 Heyman Sep 1998 A
5843188 McDonald Dec 1998 A
5860984 Chambers et al. Jan 1999 A
5868751 Feingold Feb 1999 A
5873879 Figueroa et al. Feb 1999 A
5876440 Feingold Mar 1999 A
5891931 Leboeuf et al. Apr 1999 A
5919197 McDonald Jul 1999 A
5921989 Deacon et al. Jul 1999 A
5928282 Nigam Jul 1999 A
5941886 Feingold Aug 1999 A
5944725 Cicenas et al. Aug 1999 A
5947974 Brady et al. Sep 1999 A
5947975 Kikuchi et al. Sep 1999 A
5947976 Van Noy et al. Sep 1999 A
5964802 Anello et al. Oct 1999 A
5968095 Norrby Oct 1999 A
5976150 Copeland Nov 1999 A
5984962 Anello et al. Nov 1999 A
6001107 Feingold Dec 1999 A
6010510 Brown et al. Jan 2000 A
6013101 Israel Jan 2000 A
6015842 Leboeuf et al. Jan 2000 A
6022358 Wolf et al. Feb 2000 A
6048348 Chambers et al. Apr 2000 A
6059791 Chambers May 2000 A
6074397 Chambers et al. Jun 2000 A
6102539 Tucker Aug 2000 A
6117171 Skottun Sep 2000 A
6124980 Cerbell Sep 2000 A
6129733 Brady et al. Oct 2000 A
6139576 Doyle et al. Oct 2000 A
6143000 Feingold Nov 2000 A
6143001 Brown et al. Nov 2000 A
6160084 Langer et al. Dec 2000 A
6176878 Gwon et al. Jan 2001 B1
6179843 Weiler Jan 2001 B1
6180687 Hammer et al. Jan 2001 B1
6188526 Sasaya et al. Feb 2001 B1
6190410 Lamielle et al. Feb 2001 B1
6195807 Chou Mar 2001 B1
6197059 Cumming Mar 2001 B1
6217612 Woods Apr 2001 B1
6225367 Chaouk et al. May 2001 B1
6229641 Kosaka May 2001 B1
6241737 Feingold Jun 2001 B1
6248111 Glick et al. Jun 2001 B1
6251114 Farmer et al. Jun 2001 B1
6280449 Blake Aug 2001 B1
6283975 Glick et al. Sep 2001 B1
6283976 Portney Sep 2001 B1
6299641 Woods Oct 2001 B1
6302911 Hanna Oct 2001 B1
6312433 Butts et al. Nov 2001 B1
6322589 Cumming Nov 2001 B1
6334862 Vidal et al. Jan 2002 B1
6336932 Figueroa et al. Jan 2002 B1
6342073 Cumming et al. Jan 2002 B1
6348437 Avery et al. Feb 2002 B1
6371960 Heyman et al. Apr 2002 B2
6387101 Butts et al. May 2002 B1
6387126 Cumming May 2002 B1
6388043 Langer et al. May 2002 B1
6398789 Capetan Jun 2002 B1
6406481 Feingold et al. Jun 2002 B2
6406494 Laguette et al. Jun 2002 B1
6413262 Saishin et al. Jul 2002 B2
6423094 Sarfarazi Jul 2002 B1
6436092 Peyman Aug 2002 B1
6443985 Woods Sep 2002 B1
6447520 Ott et al. Sep 2002 B1
6450642 Jethmalani et al. Sep 2002 B1
6464725 Skotton Oct 2002 B2
6468282 Kikuchi et al. Oct 2002 B2
6471708 Green Oct 2002 B2
6488708 Sarfarazi Dec 2002 B2
6491697 Clark et al. Dec 2002 B1
6493151 Schachar Dec 2002 B2
6497708 Cumming Dec 2002 B1
6503275 Cumming Jan 2003 B1
6503276 Lang et al. Jan 2003 B2
6506195 Chambers et al. Jan 2003 B2
6517577 Callahan et al. Feb 2003 B1
6528602 Freeman et al. Mar 2003 B1
6537283 Van Noy Mar 2003 B2
6551354 Ghazizadeh et al. Apr 2003 B1
6552860 Alden Apr 2003 B1
6554859 Lang et al. Apr 2003 B1
6585768 Hamano et al. Jul 2003 B2
6589550 Hodd et al. Jul 2003 B1
6592621 Domino Jul 2003 B1
6599317 Weinschenk, III et al. Jul 2003 B1
6601956 Jean et al. Aug 2003 B1
6605093 Blake Aug 2003 B1
6610350 Suzuki et al. Aug 2003 B2
6616691 Tran Sep 2003 B1
6616692 Glick et al. Sep 2003 B1
6638304 Azar Oct 2003 B2
6638305 Laguette Oct 2003 B2
6638306 Cumming Oct 2003 B2
6645245 Preussner Nov 2003 B1
6645246 Weinschenk, III et al. Nov 2003 B1
6656223 Brady Dec 2003 B2
6660035 Lang et al. Dec 2003 B1
6692525 Brady et al. Feb 2004 B2
6695881 Peng et al. Feb 2004 B2
6709108 Levine et al. Mar 2004 B2
6712848 Wolf et al. Mar 2004 B1
6723104 Ott Apr 2004 B2
6730123 Klopotek May 2004 B1
6733507 McNicholas et al. May 2004 B2
6743388 Sridharan et al. Jun 2004 B2
6749632 Sandstedt et al. Jun 2004 B2
6749634 Hanna Jun 2004 B2
6786934 Zadno-Azizi et al. Sep 2004 B2
6818158 Pham et al. Nov 2004 B2
6827738 Willis et al. Dec 2004 B2
6836374 Esch et al. Dec 2004 B2
6860601 Shadduck Mar 2005 B2
6878320 Alderson et al. Apr 2005 B1
6884261 Zadno-Azizi et al. Apr 2005 B2
6899732 Zadno-Azizi et al. May 2005 B2
6899850 Haywood et al. May 2005 B2
6914247 Duggan et al. Jul 2005 B2
6921405 Feingold et al. Jul 2005 B2
6923815 Brady et al. Aug 2005 B2
6926736 Peng et al. Aug 2005 B2
6935743 Shadduck Aug 2005 B2
6949093 Peyman Sep 2005 B1
6966649 Shadduck Nov 2005 B2
6969403 Peng et al. Nov 2005 B2
7001374 Peyman Feb 2006 B2
7014641 Kobayashi et al. Mar 2006 B2
7060094 Shahinpoor et al. Jun 2006 B2
7068439 Esch Jun 2006 B2
7070276 Koretz Jul 2006 B2
7074227 Portney Jul 2006 B2
7122053 Esch Oct 2006 B2
7144423 McDonald Dec 2006 B2
7156854 Brown et al. Jan 2007 B2
7217288 Esch et al. May 2007 B2
7241312 Lai et al. Jul 2007 B2
7247168 Esch et al. Jul 2007 B2
7247689 Makker et al. Jul 2007 B2
7261737 Esch et al. Aug 2007 B2
7264351 Shadduck Sep 2007 B2
7276619 Kunzler et al. Oct 2007 B2
7278739 Shadduck Oct 2007 B2
7311194 Jin et al. Dec 2007 B2
7335209 Meyer Feb 2008 B2
7416300 Wei et al. Aug 2008 B2
7429263 Vaquero et al. Sep 2008 B2
7438723 Esch Oct 2008 B2
7453646 Lo Nov 2008 B2
7485144 Esch Feb 2009 B2
7494505 Kappelhof et al. Feb 2009 B2
7637947 Smith et al. Dec 2009 B2
7675686 Lo et al. Mar 2010 B2
7753953 Yee Jul 2010 B1
7759408 Schorzman et al. Jul 2010 B2
7763069 Brady et al. Jul 2010 B2
7776088 Shadduck Aug 2010 B2
7878655 Salvati et al. Feb 2011 B2
7971997 Hiramatsu et al. Jul 2011 B2
7988290 Campbell et al. Aug 2011 B2
7988292 Neal et al. Aug 2011 B2
7988293 Raymond et al. Aug 2011 B2
8048155 Shadduck Nov 2011 B2
8158712 Your Apr 2012 B2
8162927 Peyman Apr 2012 B2
8241355 Brady et al. Aug 2012 B2
8246631 Pynson Aug 2012 B2
8303656 Shadduck Nov 2012 B2
8314927 Choi et al. Nov 2012 B2
8328869 Smiley et al. Dec 2012 B2
8361145 Scholl et al. Jan 2013 B2
8382769 Inoue Feb 2013 B2
8403941 Peterson et al. Mar 2013 B2
8425599 Shadduck Apr 2013 B2
8447086 Hildebrand et al. May 2013 B2
8454688 Esch et al. Jun 2013 B2
8475526 Pynson Jul 2013 B2
8613766 Richardson et al. Dec 2013 B2
8632589 Helmy Jan 2014 B2
8668734 Hildebrand et al. Mar 2014 B2
8758361 Kobayashi et al. Jun 2014 B2
8888845 Vaquero et al. Nov 2014 B2
8900298 Anvar et al. Dec 2014 B2
8956408 Smiley et al. Feb 2015 B2
8961601 Biddle et al. Feb 2015 B2
8968396 Matthews et al. Mar 2015 B2
8992609 Shadduck Mar 2015 B2
9005282 Chang et al. Apr 2015 B2
9034035 Betser et al. May 2015 B2
9044317 Hildebrand et al. Jun 2015 B2
9226819 Downer Jan 2016 B2
9277987 Smiley et al. Mar 2016 B2
9456895 Shadduck Oct 2016 B2
9610155 Matthews Apr 2017 B2
9693858 Hildebrand et al. Jul 2017 B2
20010001836 Cumming May 2001 A1
20010016771 Cumming Aug 2001 A1
20010039449 Johnson et al. Nov 2001 A1
20010051826 Bogaert et al. Dec 2001 A1
20020046783 Johnson et al. Apr 2002 A1
20020055776 Juan, Jr. May 2002 A1
20020055777 Cumming et al. May 2002 A1
20020072795 Green Jun 2002 A1
20020095212 Boehm Jul 2002 A1
20020107568 Zadno-Azizi et al. Aug 2002 A1
20020111678 Zadno-Azizi et al. Aug 2002 A1
20020116057 Ting et al. Aug 2002 A1
20020116058 Zadno-Azizi et al. Aug 2002 A1
20020116059 Zadno-Azizi et al. Aug 2002 A1
20020116060 Nguyen et al. Aug 2002 A1
20020116061 Zadno-Azizi et al. Aug 2002 A1
20020133167 Harish et al. Sep 2002 A1
20020133228 Sarver Sep 2002 A1
20020161434 Laguette et al. Oct 2002 A1
20020161435 Portney Oct 2002 A1
20020177896 Israel Nov 2002 A1
20020193876 Lang et al. Dec 2002 A1
20030003295 Dreher et al. Jan 2003 A1
20030004569 Haefliger Jan 2003 A1
20030018384 Valyunin et al. Jan 2003 A1
20030042176 Alderson et al. Mar 2003 A1
20030050695 Lin et al. Mar 2003 A1
20030050696 Cumming Mar 2003 A1
20030060878 Shadduck Mar 2003 A1
20030060881 Glick et al. Mar 2003 A1
20030078656 Nguyen Apr 2003 A1
20030078657 Zadno-Azizi et al. Apr 2003 A1
20030078658 Zadno-Azizi Apr 2003 A1
20030083744 Khoury May 2003 A1
20030109925 Ghazizadeh et al. Jun 2003 A1
20030109926 Portney Jun 2003 A1
20030130732 Sarfarazi Jul 2003 A1
20030135272 Brady et al. Jul 2003 A1
20030158599 Brady et al. Aug 2003 A1
20030171808 Phillips Sep 2003 A1
20030183960 Buazza et al. Oct 2003 A1
20030187505 Liao Oct 2003 A1
20030199977 Cumming Oct 2003 A1
20030236376 Kindt-Larsen et al. Dec 2003 A1
20040001180 Epstein Jan 2004 A1
20040006386 Valint et al. Jan 2004 A1
20040006387 Kelman Jan 2004 A1
20040008419 Schachar Jan 2004 A1
20040015236 Sarfarazi Jan 2004 A1
20040039446 McNicholas Feb 2004 A1
20040054408 Glick et al. Mar 2004 A1
20040059343 Shearer et al. Mar 2004 A1
20040066489 Benedikt et al. Apr 2004 A1
20040082993 Woods Apr 2004 A1
20040082994 Woods et al. Apr 2004 A1
20040085511 Uno et al. May 2004 A1
20040085515 Roffman et al. May 2004 A1
20040088050 Norrby et al. May 2004 A1
20040111151 Paul et al. Jun 2004 A1
20040111152 Kelman Jun 2004 A1
20040111153 Woods et al. Jun 2004 A1
20040127984 Paul et al. Jul 2004 A1
20040162612 Portney et al. Aug 2004 A1
20040181279 Nun Sep 2004 A1
20040186868 Kim Sep 2004 A1
20040193263 Bryan Sep 2004 A1
20040230203 Yaguchi Nov 2004 A1
20040267359 Makker et al. Dec 2004 A1
20050021139 Shadduck Jan 2005 A1
20050033308 Callahan et al. Feb 2005 A1
20050038446 Vanderbilt et al. Feb 2005 A1
20050049606 Vaquero et al. Mar 2005 A1
20050080484 Marmo et al. Apr 2005 A1
20050090612 Soane et al. Apr 2005 A1
20050113911 Peyman May 2005 A1
20050125000 Tourrette et al. Jun 2005 A1
20050125055 Deacon et al. Jun 2005 A1
20050125056 Deacon et al. Jun 2005 A1
20050131535 Woods Jun 2005 A1
20050143750 Vaquero Jun 2005 A1
20050143751 Makker et al. Jun 2005 A1
20050147735 Lowery et al. Jul 2005 A1
20050149057 Rathert Jul 2005 A1
20050165410 Zadno-Azizi et al. Jul 2005 A1
20050222577 Vaquero Oct 2005 A1
20050222578 Vaquero Oct 2005 A1
20050222579 Vaquero et al. Oct 2005 A1
20050251253 Gross Nov 2005 A1
20050251254 Brady et al. Nov 2005 A1
20050259221 Marmo Nov 2005 A1
20050264756 Esch Dec 2005 A1
20050283162 Stratas Dec 2005 A1
20050283164 Wu et al. Dec 2005 A1
20060020267 Marmo Jan 2006 A1
20060020268 Brady et al. Jan 2006 A1
20060036262 Hohl Feb 2006 A1
20060069433 Nun Mar 2006 A1
20060085013 Dek et al. Apr 2006 A1
20060097413 Ghazizadeh et al. May 2006 A1
20060100703 Evans et al. May 2006 A1
20060116763 Simpson Jun 2006 A1
20060129129 Smith Jun 2006 A1
20060134173 Liu et al. Jun 2006 A1
20060135642 Makker et al. Jun 2006 A1
20060142780 Pynson et al. Jun 2006 A1
20060142781 Pynson et al. Jun 2006 A1
20060158611 Piers et al. Jul 2006 A1
20060183041 Erk et al. Aug 2006 A1
20060184181 Cole et al. Aug 2006 A1
20060200167 Peterson et al. Sep 2006 A1
20060253196 Woods Nov 2006 A1
20070004886 Schorzman et al. Jan 2007 A1
20070005136 Richardson Jan 2007 A1
20070021831 Clarke Jan 2007 A1
20070027538 Aharoni et al. Feb 2007 A1
20070050023 Bessiere et al. Mar 2007 A1
20070078515 Brady Apr 2007 A1
20070088433 Esch et al. Apr 2007 A1
20070100445 Shadduck May 2007 A1
20070118216 Pynson May 2007 A1
20070129801 Cumming Jun 2007 A1
20070156236 Stenger Jul 2007 A1
20070162112 Burriesci et al. Jul 2007 A1
20070213817 Esch et al. Sep 2007 A1
20070244561 Nun Oct 2007 A1
20070260157 Norrby Nov 2007 A1
20070265636 Huynh Nov 2007 A1
20080004699 Nun Jan 2008 A1
20080015689 Esch et al. Jan 2008 A1
20080027537 Gerlach et al. Jan 2008 A1
20080033449 Cole et al. Feb 2008 A1
20080035243 Breitenkamp et al. Feb 2008 A1
20080046074 Smith et al. Feb 2008 A1
20080046075 Esch et al. Feb 2008 A1
20080058830 Cole et al. Mar 2008 A1
20080065096 Kappelhof et al. Mar 2008 A1
20080071286 Kobayashi et al. Mar 2008 A1
20080097460 Boukhny et al. Apr 2008 A1
20080119865 Meunier et al. May 2008 A1
20080139769 Iwamoto et al. Jun 2008 A1
20080179770 Rooney et al. Jul 2008 A1
20080188930 Mentak et al. Aug 2008 A1
20080200921 Downer Aug 2008 A1
20080243247 Poley et al. Oct 2008 A1
20080269887 Cumming Oct 2008 A1
20080300680 Nun Dec 2008 A1
20080306587 Your Dec 2008 A1
20090005865 Smiley et al. Jan 2009 A1
20090018512 Charles Jan 2009 A1
20090018548 Charles Jan 2009 A1
20090024136 Martin et al. Jan 2009 A1
20090076602 Ho et al. Mar 2009 A1
20090112313 Mentak Apr 2009 A1
20090118739 Kappelhof et al. May 2009 A1
20090124773 Zhou et al. May 2009 A1
20090149952 Shadduck Jun 2009 A1
20090171366 Tanaka Jul 2009 A1
20090204123 Downer Aug 2009 A1
20090228101 Zadno-Azizi Sep 2009 A1
20090234366 Tsai et al. Sep 2009 A1
20090234449 DeJuan, Jr. et al. Sep 2009 A1
20090248154 Dell Oct 2009 A1
20090264998 Mentak et al. Oct 2009 A1
20090281620 Sacharoff et al. Nov 2009 A1
20090292293 Bogaert et al. Nov 2009 A1
20090312836 Pinchuk et al. Dec 2009 A1
20090318933 Anderson Dec 2009 A1
20090319040 Khoury Dec 2009 A1
20100016963 Park Jan 2010 A1
20100039709 Lo Feb 2010 A1
20100063588 Park Mar 2010 A1
20100069522 Linhardt et al. Mar 2010 A1
20100094412 Wensrich Apr 2010 A1
20100131058 Shadduck May 2010 A1
20100161049 Inoue Jun 2010 A1
20100179653 Argento et al. Jul 2010 A1
20100204705 Brown et al. Aug 2010 A1
20100228344 Shadduck Sep 2010 A1
20100228346 Esch Sep 2010 A1
20110118834 Lo et al. May 2011 A1
20110153015 Simonov et al. Jun 2011 A1
20110282442 Scholl et al. Nov 2011 A1
20110288638 Smiley et al. Nov 2011 A1
20120078363 Lu Mar 2012 A1
20120078364 Stenger Mar 2012 A1
20120116506 Compertore May 2012 A1
20120179249 Coleman Jul 2012 A1
20120221102 Tanaka et al. Aug 2012 A1
20120226351 Peyman Sep 2012 A1
20120253458 Geraghty et al. Oct 2012 A1
20120253459 Reich et al. Oct 2012 A1
20130053954 Rao et al. Feb 2013 A1
20130060331 Shadduck Mar 2013 A1
20130103146 Smiley et al. Apr 2013 A1
20130128368 Costache et al. May 2013 A1
20130131794 Smiley et al. May 2013 A1
20130250239 Hildebrand et al. Sep 2013 A1
20130268070 Esch et al. Oct 2013 A1
20140142587 Walter et al. May 2014 A1
20150087743 Anvar et al. Mar 2015 A1
20150202041 Shadduck Jul 2015 A1
20150238310 Matthews et al. Aug 2015 A1
20160038278 Matthews Feb 2016 A1
20160113761 Nishi et al. Apr 2016 A1
20160184091 Smiley et al. Jun 2016 A1
20160184092 Smiley et al. Jun 2016 A1
20160262875 Smith et al. Sep 2016 A1
20170020662 Shadduck Jan 2017 A1
20170049561 Smiley et al. Feb 2017 A1
20170079773 Matthews et al. Mar 2017 A1
20180125640 Smiley et al. May 2018 A1
20180132997 Smiley et al. May 2018 A1
20180147051 Scholl et al. May 2018 A1
20180153682 Hajela et al. Jun 2018 A1
Foreign Referenced Citations (66)
Number Date Country
1200659 Dec 1998 CN
1283974 Feb 2001 CN
1378440 Nov 2002 CN
1384727 Dec 2002 CN
101039635 Sep 2007 CN
101277659 Oct 2008 CN
102271622 Dec 2011 CN
0898972 Mar 1999 EP
1356791 Apr 2006 EP
1332731 Aug 2007 EP
1659991 May 2009 EP
2060243 May 2009 EP
2192934 May 2011 EP
2346441 Mar 2013 EP
2655841 Jun 1991 FR
2784575 Apr 2000 FR
07044938 May 1995 JP
08501715 Feb 1996 JP
08224295 Sep 1996 JP
09294754 Nov 1997 JP
10206609 Aug 1998 JP
11047168 Feb 1999 JP
11056998 Mar 1999 JP
11169391 Jun 1999 JP
11276509 Oct 1999 JP
11332903 Dec 1999 JP
2001502592 Feb 2001 JP
2003144387 May 2003 JP
2003-524503 Aug 2003 JP
2003530978 Oct 2003 JP
2006341094 Dec 2006 JP
2007513715 May 2007 JP
2007518447 Jul 2007 JP
2008531069 Aug 2008 JP
2008307394 Dec 2008 JP
2009034451 Feb 2009 JP
2009291399 Dec 2009 JP
201017459 Jan 2010 JP
1810052 Apr 1993 SU
WO9502378 Jan 1995 WO
WO9706751 Feb 1997 WO
WO0041650 Jul 2000 WO
WO0064655 Nov 2000 WO
WO0160286 Aug 2001 WO
WO0189435 Nov 2001 WO
WO0197742 Dec 2001 WO
WO02051338 Jul 2002 WO
WO2004010895 Feb 2004 WO
WO2004046768 Jun 2004 WO
WO2004072689 Aug 2004 WO
WO2005018504 Mar 2005 WO
WO2005084588 Sep 2005 WO
WO2006004707 Jan 2006 WO
WO2006047383 May 2006 WO
WO2006088440 Aug 2006 WO
WO2007005529 Jan 2007 WO
WO2007005692 Jan 2007 WO
WO2007030095 Mar 2007 WO
WO2007061688 May 2007 WO
WO2007128423 Nov 2007 WO
WO2007138564 Dec 2007 WO
WO2009100322 Aug 2009 WO
WO2009154455 Dec 2009 WO
WO2011119334 Sep 2011 WO
WO2012006186 Jan 2012 WO
WO2012129419 Sep 2012 WO
Non-Patent Literature Citations (38)
Entry
Hildebrand et al.; U.S. Appl. No. 15/760,640 entitled “Accommodating intraocular lenses and methods of manufacturing,” filed Mar. 16, 2018.
Baughman et al., “Negative poisson's ratios for extreme states of matter,” Science, vol. 288, pp. 2018-2022, Jun. 16, 2000.
Baughman, “Avoiding the shrink,” Nature, vol. 425, pp. 667, Oct. 16, 2003.
Conlisk, A. T. et al; Mass Transfer and Flow in Electrically Charged Micro- and Nano-channels; Analytical Chemistry, vol. 74; iss. 9; pp. 2139-2150; May 2002.
Dubbelman et al.; The Thickness of the Aging Human Lens Obtained from Corrected Scheimpflug Images; Optometry & Vison Science; vo. 78; iss. 6; pp. 411-416; Jun. 2001.
Gorder, P. F.; Electricity can pump medicine in implanted medical devices; Ohio State Research News; 3 pgs.; May 2, 2002 (printed from internet Aug. 19, 2010).
Gordon, “Applications of shape memory polyurethanes,” Proceedings of the First Intl Conf. on Shape Memory and Superelastic Tech., Asilomar Conference Center, Pacific Grove, CA, USA, pp. 115-120, Mar. 1994.
Gruber et al.; Exhaustive soxhlet extraction for the complete removal of residual compounds . . . ; Journal of Biomedical Materials Research; vol. 53; No. 5; pp. 445-448; Mar. 2000.
Jeon et al., “Shape memory and nanostructure in poly(norbornyl-POSS) copolymers,” Polymer International, vol. 49, pp. 453-457, May 2000.
Kim et al., “Polyurethanes having shape memory effects,” Polymer, vol. 37, No. 26, pp. 5781-5793, Dec. 1996.
Lakes et al., “Dramatically stiffer elastic composite materials due to negative stiffness phase?,” Journal of the Mechanics and Physics of Solids, vol. 50, pp. 979-1009, May 2002.
Lakes et al., “Extreme damping in composite materials with negative-stiffness inclusions,” Nature, vol. 410, pp. 565-567, Mar. 29, 2001.
Lakes et al., “Microbuckling instability in elastomeric cellular sollids,” J. Materials Science, vol. 28, pp. 4667-4672, Jan. 1993.
Lakes, “A broader view of membranes,” Nature, vol. 414, pp. 503-504, Nov. 29, 2001.
Lakes; Deformations in extreme matter; Science; perspectives; vol. 288; No. 5473; pp. 1976-1977; Jun. 16, 2000.
Lakes, “Extreme damping in compliant composites with a negative-stiffness phase,” Philosophical Magazine Letters, vol. 81, No. 2, pp. 95-100, Feb. 2001.
Lakes, “Extreme damping in composite materials with a negative stiffness phase,” Physical Review Letters, vol. 86, No. 13, pp. 2897-2900, Mar. 26, 2001.
Lakes, “Negative poisson's ratio materials,” Science, vol. 238, pp. 551, Oct. 23, 1987.
Lakes, “No contractile obligations,” Nature, vol. 358, pp. 713-714, Dec. 31, 1992.
Langenbucher et al., “Computerized calculation scheme for toric intraocular lenses,” Acta Ophthalmologica Scandinavica, vol. 82, No. 3, pp. 270-276, Jun. 2004.
Lendlein et al., “Biodegradable, elastic shape-memory polymers for potential biomedical applications”, Science; vol. 296; pp. 1673-1676; May 31, 2002.
Lendlein et al., “Shape-memory polymers,” Angew. Chem. Int. Ed.; vol. 41; pp. 2034-2057; Jun. 2002.
Li et al., “Crystallinity and morphology of segmented polyurethanes with different soft-segment length,” Journal of Applied Polymer Science, vol. 62, pp. 631-638, Oct. 1996.
Liu et al., “Thermomechanical characterization of a tailored series of shape memory polymers,” Journal of Applied Medical Polymers, vol. 6, No. 2, Dec. 2002.
Mather et al., “Strain recovery in POSS hybrid thermoplastics,” Polymer Preprints, vol. 41, No. 1, pp. 528-529, Feb. 2000.
Metcalfe et al., “Cold hibernated elastic memory foams for endovascular interventions,” Biomaterials, vol. 24, pp. 491-497, Feb. 2003.
Qiao et al.; Bio-inspired accommodating fluidic intraocular lens; Optics Letters; vol. 34; No. 20; pp. 3214-3216; Oct. 15, 2009.
Rosales et al.; Pentacam Scheimpflug QuantitativeImaging of the Crystalline Lens andIntraocular Lens; J. Refractive Surgery; vol. 25; pp. 421-428; May 2009.
Takahashi et al., “Structure and properties of shape-memory polyurethane block copolymers,” Journal of Applied Polymer Science, vol. 60, pp. 1061-1069, May 1996.
Tehrani et al.; Capsule measuring ring to predict capsular bag diameter and follow its course after foldable intraocular lens implantation; J Cataract Refract Surg.; vol. 29; No. 11; pp. 2127-2134; Nov. 2003.
Tobushi et al., “Thermomechanical properties of shape memory polymers of polyurethane series and their applications,” Journal de Physique IV, Colloque C1, vol. 6, pp. 377-384, Aug. 1996.
Vass et al.; Prediction of pseudophakic capsular bag diameter based on biometric variables; J Cataract Refract Surg.; vol. 25; pp. 1376-1381; Oct. 1999.
Wang et al., “Deformation of extreme viscoelastic metals and composites,” Materials Science and Enginerring A, vol. 370, pp. 41-49, Apr. 2004.
Wang et al., “Extreme stiffness systems due to negative stiffness elements,” American Journal of Physics, vol. 72, No. 1, pp. 40-50, Jan. 2004.
Wang et al., “Stable extremely-high-damping discrete viscoelastic systems due to native stiffness elements,” Applied Physics Letters, vol. 84, No. 22, pp. 4451-4453, May 31, 2004.
Wyant et al; “Basic Wavefront Aberration Theory for Optical Metrology,” Applied Optics and Optical Engineering, vol. XI, Aug. 10, 1992: pp. 1, 28-39.
Xu et al., “Making negative poisson's ratio microstructures by soft lithography,” Advanced Materials, vol. 11, No. 14, pp. 1186-1189, Jun. 1999.
Smiley et al.; U.S. Appl. No. 15/457,934 entitled “Lens delivery system,” filed Mar. 13, 2017.
Related Publications (1)
Number Date Country
20170290658 A1 Oct 2017 US
Provisional Applications (1)
Number Date Country
61363155 Jul 2010 US
Continuations (3)
Number Date Country
Parent 14728824 Jun 2015 US
Child 15635080 US
Parent 14163794 Jan 2014 US
Child 14728824 US
Parent 13180427 Jul 2011 US
Child 14163794 US