Claims
- 1. A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound which iodinated compound is an aliphatic carboxylic acid of from 6-17 carbon atoms in the aliphatic chain exclusive of any branching in said aliphatic chain, said carboxylic acid being (a) iodinated directly or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
- 2. A process according to claim 1 wherein the carboxylic acid has an aromatic substituent to which the iodine is bound.
- 3. A process according to claim 2 wherein the iodinated compound is of the formula (I).sub.n X--R--CO.sub.2 H wherein X is an aromatic group, .sub.n is an integer of from 1-3 per aromatic nucleus and R is an aliphatic group of from 5 to 16 carbon atoms exclusive of branching.
- 4. A process according to claim 3 wherein the iodinated compound is iodoundecylenic acid.
- 5. A process for visualization of the GI tract of a mammal comprising administering to the mammal a diagnostically effective amount of a contrast agent comprising an aqueous emulsion of an iodinated compound convertible at least in part in the GI tract to an aliphatic carboxylic acid of from 6 to 17 carbon atoms in the aliphatic chain exclusive of any branching in the aliphatic chain, which compound is (a) iodinated directly in the aliphatic chain of the carboxylic acid or by incorporation therein of an iodinated substituent and (b) slightly soluble in water and which emulsion shows no visible evidence of separation into oil and water phases in the GI tract for at least about one hour as demonstrated by radiographic examination.
- 6. A process according to claim 5 wherein the aliphatic chain has an aromatic substituent to which the iodine is bound.
- 7. A process according to claim 6 wherein the iodinated compound is a compound convertible at least in part into a carboxylic acid of the formula (I).sub.n X--R--CO.sub.2 H wherein X is an aromatic group, .sub.n is an integer of from 1-3 per aromatic nucleus and R is an aliphatic group of from 5 to 16 carbon atoms exclusive of branching.
- 8. A process according to claim 5 wherein the iodinated compound convertible into the carboxylic acid is an ester, amide, anhydride or acid halide of the carboxylic acid.
- 9. A process according to claim 7 wherein the compound has the formula (I).sub.n X--R--CO--R' wherein X is an aromatic group, .sub.n is an integer of from 1-3 per aromatic nucleus, R is an aliphatic group of from 5-16 carbon atoms exclusive of branching and R' is halogen or the residue of an alcohol, amine r carboxylic acid used to form an ester, amide or anhydride of the carboxylic acid.
- 10. A process according to claim 9 wherein the compound is iophendylate.
- 11. A process according to claims 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 wherein the contrast agent is comprised of up to about 45% by volume of the iodinated compound.
- 12. A process according to claim 11 wherein the contrast agent is administered orally.
- 13. A process according to claim 11 wherein the contrast agent is administered rectally.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of application Ser. No. 07/298,772, filed Jan. 17, 1989, now abandoned, which is a continuation of application Ser. No. 06/566,494, filed Dec. 29, 1983, now abandoned, the disclosures of which are incorporated by reference.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2348231 |
Strain et al. |
May 1944 |
|
Non-Patent Literature Citations (2)
Entry |
Pirkey et al. Radiology 55:89-92 (1950). |
Teplick et al. Radiology 82:478-485 (1964). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
566494 |
Dec 1983 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
298772 |
Jan 1989 |
|