Claims
- 1. A process for producing an optically active allyl alcohol derivative represented by formula (VI): ##STR27## wherein R.sup.1 represents a phenyl group which may be substituted and R.sup.2 represents an alkyl group, comprising enantioselective hydrogenating an .alpha.,.beta.-unsaturated ketone represented by formula (V): ##STR28## wherein R.sup.1 and R.sup.2 are as defined above, in the presence of an iridium-optically active phosphine complex represented by formula (I):
- [H.sub.2 Ir(L.sup.1)(L.sup.2)]Y (I)
- wherein L.sup.1 represents an optically active phosphine compound represented by formula (II): ##STR29## wherein Ar represents a phenyl group or a p- and/or m-lower alkyl-substituted phenyl group, or formula (III): ##STR30## L.sup.2 represents a tertiary phosphine compound represented by formula (IV): ##STR31## wherein Z represents a lower alkoxy group or a di-lower alkylamino group; and A represents an integer of from 1 to 3; Y represents BF.sub.4, PF.sub.6, ClO.sub.4, or BPh.sub.4, wherein Ph represents a phenyl group.
- 2. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein the complex of formula (I) is present in an amount of 1/1,000 to 1/10 mol per mol of substrate.
- 3. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein the hydrogenating is carried out at a temperature of 5.degree. to 50.degree. C.
- 4. A process for producing an optically active allyl alcohol as in claim 3, wherein the hydrogenating is carried out at a temperature of 20.degree. to 30.degree. C.
- 5. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein the hydrogenating is carried out under a hydrogen pressure of from 2 to 100 kg/cm.sup.2.
- 6. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein the complex represented by formula (I) is present in an amount of 1/1,000 to 1/10 mol per mol of substrate, the hydrogenating is carried out at a temperature of 5.degree. to 50.degree. C. and the hydrogenating is carried out under a hydrogen pressure of 2 to 100 kg/cm.sup.2.
- 7. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein the substrate is dissolved in a solvent selected from the group consisting of methanol, tetrahydrofuran, methylene chloride, benzene and mixtures of any two or more of the above solvents.
- 8. A process for producing an optically active allyl alcohol derivative as in claim 1, wherein R.sup.2 is a methyl group.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2-263439 |
Oct 1990 |
JPX |
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Parent Case Info
This is a divisional of application Ser. No. 07/769,280 filed Oct. 1, 1991.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4924029 |
Harsy |
May 1990 |
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Foreign Referenced Citations (3)
Number |
Date |
Country |
0104376 |
Apr 1984 |
EPX |
0245959 |
Nov 1987 |
EPX |
1135979 |
Dec 1968 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
769280 |
Oct 1991 |
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