Claims
- 1. An isoindoline of the formula: ##SPC6##
- wherein Ar is pyridyl, unsubstituted or substituted by one or two substituents selected from halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms, cyano, nitro and trifluoromethyl, X and Y when taken singly represent hydrogen or alkoxy of 1 through 4 carbon atoms, or X and Y when taken together represent methylenedioxy, and R.sub.1 and R.sub.2 represent hydrogen or alkyl of 1 through 4 carbon atoms, or a non-toxic pharmaceutically acceptable acid addition salts thereof.
- 2. An isoindoline according to claim 1 wherein Ar is pyridyl unsubstituted or substituted by halogen, alkyl of 1 through 4 carbon atoms, alkoxy of 1 through 4 carbon atoms or trifluoromethyl, X and Y both represent hydrogen or both represent methoxy, R.sub.1 represents alkyl of 1 through 4 carbon atoms and R.sub.2 represents hydrogen, or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 3. An isoindoline derivative according to claim 1 wherein the substituent or substituents on the radical represented by the symbol Ar is, or are, selected from chlorine, methyl, methoxy and trifluoromethyl, or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 4. An isoindoline derivative according to claim 1 wherein R.sub.1 represents isopropyl or t.-butyl and R.sub.2 represents hydrogen.
- 5. The isoindoline derivative according to claim 1 which is 2-(5-chloropyrid-2-yl)-3-(2-hydroxy-3-isopropylamino-propoxy)-isoindolin-1-one or a non-toxic pharmaceutically acceptable acid addition salt thereof.
- 6. A pharmaceutical composition useful as an anti-arrhythmic which comprises, as active ingredient, an effective amount of an isoindoline of claim 1, or a non-toxic pharmaceutically acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutically acceptable carrier.
Priority Claims (2)
Number |
Date |
Country |
Kind |
72.09207 |
Mar 1972 |
FR |
|
73.03728 |
Feb 1973 |
FR |
|
Parent Case Info
This is a division of application Ser. No. 341,307, filed Mar. 14, 1973 now U.S. Pat. No. 3,898,232.
Non-Patent Literature Citations (1)
Entry |
cotrel, Chemical Abstracts 77:5526a (1972). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
341307 |
Mar 1973 |
|