Claims
- 1. An isindoline of the formula: ##STR8## wherein Ar is pyridazinyl, unsubstituted or substituted by methyl, X and Y when taken singly represent hydrogen or alkoxy of 1 through 4 carbons atoms, or X and Y when taken together represent methylenedioxy, and R.sub.1 and R.sub.2 represent hydrogen or alkul of 1 through 4 carbon atoms, and non-toxic pharmaceutically acceptable acid addition salts thereof.
- 2. An isoindoline according to claim 1 wherein X and Y both represent hydrogen or both represent methoxy, R.sub.1 represents alkyl of 1 through 4 carbon atoms and R.sub.2 represents hydrogen, and non-toxic pharmaceutically acceptable acid addition salts thereof.
- 3. An isoindoline derivative according to claim 19 wherein R.sub.1 represents isopropyl or t.-butyl and R.sub.2 represents hydrogen.
- 4. The isoindoline derivative according to claim 2 which is 3-(2-hydroxy-3-isopropylamino-propoxy)-2-(6-methylpyridazin-3-yl)-isoindolin-1-one or a non-toxic pharmaceutically acceptable addition salt thereof.
- 5. A pharmaceutical composition useful as an anti-arrhythmic which comprises, as active ingredient, an effective amount of an isoindoline of claim 1 or a non-toxic pharmaceutically acceptable acid addition salt thereof, in association with a significant amount of a pharmaceutically acceptable carrier.
Priority Claims (2)
Number |
Date |
Country |
Kind |
72.09207 |
Mar 1972 |
FR |
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73.03728 |
Feb 1973 |
FR |
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Parent Case Info
This is a Division of application Ser. No. 527,031 filed Nov. 25, 1974, U.S. Pat. No. 3,987,174 which in turn is a continuation of application Ser. No. 341,307, filed Mar. 14, 1973 (now U.S. Pat. No. 3,898,232).
Non-Patent Literature Citations (3)
Entry |
S.U.C.R.P. Chem. Abs. 82, 156062a (1975). |
Cotrel et al., I, Chem. Abs. 79, 146393h (1973). |
Cotrel et al., II, Chem. Abs. 78, 72197c (1973). |
Divisions (1)
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Number |
Date |
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Parent |
527031 |
Nov 1974 |
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Continuations (1)
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341307 |
Mar 1973 |
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