Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof

Abstract

The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphatase peptides, and methods of identifying modulators of the phosphatase peptides.

Description

FIELD OF THE INVENTION

The present invention is in the field of phosphatase proteins that are related to the protein tyrosine phosphatase subfamily, recombinant DNA molecules and protein production. The present invention specifically provides novel phosphatase peptides and proteins and nucleic acid molecules encoding such peptide and protein molecules, all of which are useful in the development of human therapeutics and diagnostic compositions and methods.

BACKGROUND OF THE INVENTION

Phosphatase proteins, particularly members of the protein tyrosine phosphatase subfamily, are a major target for drug action and development. Accordingly, it is valuable to the field of pharmaceutical development to identify and characterize previously unknown members of this subfamily of phosphatase proteins. The present invention advances the state of the art by providing a previously unidentified human phosphatase proteins that have homology to members of the protein tyrosine phosphatase subfamily.

Protein Phosphatase

Cellular signal transduction is a fundamental mechanism whereby external stimuli that regulate diverse cellular processes are relayed to the interior of cells. The biochemical pathways through which signals are transmitted within cells comprise a circuitry of directly or functionally connected interactive proteins. One of the key biochemical mechanisms of signal transduction involves the reversible phosphorylation of certain residues on proteins. The phosphorylation state of a protein may affect its conformation and/or enzymic activity as well as its cellular location. The phosphorylation state of a protein is modified through the reciprocal actions of protein phosphatases (PKs) and protein phosphatases (PPs) at various specific amino acid residues.

Protein phosphorylation is the ubiquitous strategy used to control the activities of eukaryotic cells. It is estimated that 10% of the proteins active in a typical mammalian cell are phosphorylated. The high-energy phosphate that confers activation and is transferred from adenosine triphosphate molecules to protein-by-protein phosphatases is subsequently removed from the protein-by-protein phosphatases. In this way, the phosphatases control most cellular signaling events that regulate cell growth and differentiation, cell-to-cell contacts, the cell cycle, and oncogenesis.

The protein phosphorylation/dephosphorylation cycle is one of the major regulatory mechanisms employed by eukaryotic cells to control cellular activities. It is estimated that more than 10% of the active proteins in a typical mammalian cell are phosphorylated. During protein phosphorylation/dephosphorylation, phosphate groups are transferred from adenosine triphosphate molecules to protein-by-protein phosphatases and are removed from the protein-by-protein phosphatases.

Protein phosphatases function in cellular signaling events that regulate cell growth and differentiation, cell-to-cell contacts, the cell cycle, and oncogenesis. Three protein phosphatase families have been identified as evolutionarily distinct. These include the serine/threonine phosphatases, the protein tyrosine phosphatases, and the acid/alkaline phosphatases (Carbonneau H. and Tonks N. K. (1992) Annu. Rev. Cell Biol. 8:463-93).

The serine/threonine phosphatases are either cytosolic or associated with a receptor. On the basis of their sensitivity to two thermostable proteins, inhibitors 1 and 2, and their divalent cation requirements, the serine/threonine phosphatases can be separated into four distinct groups, PP-I, PP-IIA, PP-IIB, and PP-IIC.

PP-I dephosphorylates many of the proteins phosphorylated by cylic AMP-dependent protein phosphatase and is therefore an important regulator of many cyclic AMP mediated, hormone responses in cells. PP-IIA has broad specificity for control of cell cycle, growth and proliferation, and DNA replication and is the main phosphatase responsible for reversing the phosphorylations of serine/threonine phosphatases. PP-IIB, or calcineurin (Cn), is a Ca.sup.+2-activated phosphatase; it is involved in the regulation of such diverse cellular functions as ion channel regulation, neuronal transmission, gene transcription, muscle glycogen metabolism, and lymphocyte activation.

PP-IIC is a Mg.sup.++-dependent phosphatase which participates in a wide variety of functions including regulating cyclic AMP-activated protein-phosphatase activity, Ca.sup.++-dependent signal transduction, tRNA splicing, and signal transmission related to heat shock responses. PP-IIC is a monomeric protein with a molecular mass of about 40-45 kDa. One .alpha. and several .beta. isoforms of PP-IIC have been identified (Wenk, J. et al. (1992) FEBS Lett. 297: 135-138; Terasawa, T. et al. (1993) Arch. Biochem. Biophys. 307: 342-349; and Kato, S. et al. (1995) Arch. Biochem. Biophys. 318: 387-393).

The levels of protein phosphorylation required for normal cell growth and differentiation at any time are achieved through the coordinated action of PKs and PPS. Depending on the cellular context, these two types of enzymes may either antagonize or cooperate with each other during signal transduction. An imbalance between these enzymes may impair normal cell functions leading to metabolic disorders and cellular transformation.

For example, insulin binding to the insulin receptor, which is a PTK, triggers a variety of metabolic and growth promoting effects such as glucose transport, biosynthesis of glycogen and fats, DNA synthesis, cell division and differentiation. Diabetes mellitus, which is characterized by insufficient or a lack of insulin signal transduction, can be caused by any abnormality at any step along the insulin signaling pathway. (Olefsky, 1988, in “Cecil Textbook of Medicine,” 18th Ed., 2:1360-81).

It is also well known, for example, that the overexpression of PTKs, such as HER2, can play a decisive role in the development of cancer (Slamon et al., 1987, Science 235:77-82) and that antibodies capable of blocking the activity of this enzyme can abrogate tumor growth (Drebin et al., 1988, Oncogene 2:387-394). Blocking the signal transduction capability of tyrosine phosphatases such as Flk-1 and the PDGF receptor have been shown to block tumor growth in animal models (Millauer et al., 1994, Nature 367:577; Ueno et al., Science, 252:844-848).

Relatively less is known with respect to the direct role of phosphatases in signal transduction; PPs may play a role in human diseases. For example, ectopic expression of RPTP.alpha. produces a transformed phenotype in embryonic fibroblasts (Zheng et al., Nature 359:336-339), and overexpression of RPTP.alpha. in embryonal carcinoma cells causes the cells to differentiate into a cell type with neuronal phenotype (den Hertog et al., EMBO J 12:3789-3798). The gene for human RPTP.gamma. has been localized to chromosome 3p21 which is a segment frequently altered in renal and small lung carcinoma. Mutations may occur in the extracellular segment of RPTP.gamma. which renders a RPTP that no longer respond to external signals (LaForgia et al., Wary et al., 1993, Cancer Res 52:478-482). Mutations in the gene encoding PTP1C (also known as HCP, SHP) are the cause of the moth-eaten phenotype in mice that suffer severe immunodeficiency, and systemic autoimmune disease accompanied by hyperproliferation of macrophages (Schultz et al., 1993, Cell 73:1445-1454). PTP1D (also known as Syp or PTP2C) has been shown to bind through SH2 domains to sites of phosphorylation in PDGFR, EGFR and insulin receptor substrate 1 (IRS-1). Reducing the activity of PTP1D by microinjection of anti-PTP1D antibody has been shown to block insulin or EGF-induced mitogenesis (Xiao et al., 1994, J Biol Chem 269:21244-21248).

The present invention has substantial similarity to protein tyrosine phosphatase (receptor type, Q). It is well established that protein tyrosine phosphorylation plays a key role in regulating structure proteins in migrating cells. Migrating cells interact with the extracellular matrix via focal adhesions (FA), which are contact points that link actin stress fibers to the membrane cytoskeleton and to transmembrane integrins. Engagement of integrins by the extracellular matrix in migrating cells induces tyrosine phosphorylation of several FA components including pp125FAK and paxillin. Specific PTPases have been linked to FA phosphorylation. For example LAR, a broadly expressed receptor PTPase, localizes to FAs in migrating cells but seems to be excluded from developing FAs at extending lamellopodia. This is consistent with a role of this receptor PTPase in FA disassembly by serving to dephosphorylate components that were activated initially by phosphorylation.

The potential importance of PTPases in the glomerulus has been underscored by the recent identification of GLEPP1, a type III receptor-like PTPase (rPTPase), which is localized to the specialized foot processes of the podocyte. GLEPP1 has been proposed to play a role in the regulation of podocyte foot process structure and function. In support of this hypothesis, GLEPP1 protein levels are reduced in several types of human glomerular disease and in several animal models of glomerulonephritis.

Glomerular disease is initiated by a variety of factors, including immunologic, infectious, and toxic agents, as well as hemodynamic processes. A central pathological feature of many types of acute and progressive glomerular disease is injury of mesangial cells, which respond by proliferating as well as by secreting growth factors and extracellular matrix proteins. This contributes to resolution of glomerular damage but may also lead to fibrosis, which occurs in many chronic disease processes. The glomerular mesangial cell is a mesenchymally derived cell that shares properties with fibroblasts and smooth muscle cells and provides structural support to the glomerular tuft.

PTPases play as potential mediators of the mesangial cell response in glomerular disease, because PTPases expressed in the rat anti-Thy 1 model, wherein a new receptor rPTP-GMC1, expressed by glomerular mesangial cells. rPTP-GMC1 is highly restricted to the mesangial cell and that expression is acutely up-regulated in actively proliferating and migrating mesangial cells in the anti-Thy 1 model. rPTP-GMC1 is similar in structure to GLEPP1 and may sense or regulate cell-cell or cell-matrix interactions to mediate glomerular repair. For a review, see Wright et al., J Biol Chem 1998 Sep 11;273(37):23929-37.

The discovery of a new human protein phosphatase and the polynucleotides encoding it satisfies a need in the art by providing new compositions that are useful in the diagnosis, prevention and treatment of biological processes associated with abnormal or unwanted protein phosphorylation.

SUMMARY OF THE INVENTION

The present invention is based in part on the identification of amino acid sequences of human phosphatase peptides and proteins that are related to the protein tyrosine phosphatase subfamily, as well as allelic variants and other mammalian orthologs thereof. These unique peptide sequences, and nucleic acid sequences that encode these peptides, can be used as models for the development of human therapeutic targets, aid in the identification of therapeutic proteins, and serve as targets for the development of human therapeutic agents that modulate phosphatase activity in cells and tissues that express the phosphatase. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta.

DESCRIPTION OF THE FIGURE SHEETS

FIG. 1 provides the nucleotide sequence of a cDNA molecule or transcript sequence that encodes the phosphatase protein of the present invention. (SEQ ID NO:1) In addition, structure and functional information is provided, such as ATG start, stop and tissue distribution, where available, that allows one to readily determine specific uses of inventions based on this molecular sequence. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta.

FIG. 2 provides the predicted amino acid sequence of the phosphatase of the present invention. (SEQ ID NO:2) In addition structure and functional information such as protein family, function, and modification sites is provided where available, allowing one to readily determine specific uses of inventions based on this molecular sequence.

FIG. 3 provides genomic sequences that span the gene encoding the phosphatase protein of the present invention. (SEQ ID NO:3) In addition structure and functional information, such as intron/exon structure, promoter location, etc., is provided where available, allowing one to readily determine specific uses of inventions based on this molecular sequence. 82 SNPs, including 6 indels, have been identified in the gene encoding the phosphatase protein provided by the present invention and are given in FIG. 3 .

DETAILED DESCRIPTION OF THE INVENTION

General Description

The present invention is based on the sequencing of the human genome. During the sequencing and assembly of the human genome, analysis of the sequence information revealed previously unidentified fragments of the human genome that encode peptides that share structural and/or sequence homology to protein/peptide/domains identified and characterized within the art as being a phosphatase protein or part of a phosphatase protein and are related to the protein tyrosine phosphatase subfamily. Utilizing these sequences, additional genomic sequences were assembled and transcript and/or cDNA sequences were isolated and characterized. Based on this analysis, the present invention provides amino acid sequences of human phosphatase peptides and proteins that are related to the protein tyrosine phosphatase subfamily, nucleic acid sequences in the form of transcript sequences, cDNA sequences and/or genomic sequences that encode these phosphatase peptides and proteins, nucleic acid variation (allelic information), tissue distribution of expression, and information about the closest art known protein/peptide/domain that has structural or sequence homology to the phosphatase of the present invention.

In addition to being previously unknown, the peptides that are provided in the present invention are selected based on their ability to be used for the development of commercially important products and services. Specifically, the present peptides are selected based on homology and/or structural relatedness to known phosphatase proteins of the protein tyrosine phosphatase subfamily and the expression pattern observed. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. The art has clearly established the commercial importance of members of this family of proteins and proteins that have expression patterns similar to that of the present gene. Some of the more specific features of the peptides of the present invention, and the uses thereof, are described herein, particularly in the Background of the Invention and in the annotation provided in the Figures, and/or are known within the art for each of the known protein tyrosine phosphatase family or subfamily of phosphatase proteins.

Specific Embodiments

Peptide Molecules

The present invention provides nucleic acid sequences that encode protein molecules that have been identified as being members of the phosphatase family of proteins and are related to the protein tyrosine phosphatase subfamily (protein sequences are provided in FIG. 2 , transcript/cDNA sequences are provided in FIG. 1 and genomic sequences are provided in FIG. 3 ). The peptide sequences provided in FIG. 2 , as well as the obvious variants described herein, particularly allelic variants as identified herein and using the information in FIG. 3 , will be referred herein as the phosphatase peptides of the present invention, phosphatase peptides, or peptides/proteins of the present invention.

The present invention provides isolated peptide and protein molecules that consist of, consist essentially of, or comprise the amino acid sequences of the phosphatase peptides disclosed in the FIG. 2 , (encoded by the nucleic acid molecule shown in FIG. 1 , transcript/cDNA or FIG. 3 , genomic sequence), as well as all obvious variants of these peptides that are within the art to make and use. Some of these variants are described in detail below.

As used herein, a peptide is said to be “isolated” or “purified” when it is substantially free of cellular material or free of chemical precursors or other chemicals. The peptides of the present invention can be purified to homogeneity or other degrees of purity. The level of purification will be based on the intended use. The critical feature is that the preparation allows for the desired function of the peptide, even if in the presence of considerable amounts of other components (the features of an isolated nucleic acid molecule is discussed below).

In some uses, “substantially free of cellular material” includes preparations of the peptide having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the peptide is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation.

The language “substantially free of chemical precursors or other chemicals” includes preparations of the peptide in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of the phosphatase peptide having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.

The isolated phosphatase peptide can be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant), or synthesized using known protein synthesis methods. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. For example, a nucleic acid molecule encoding the phosphatase peptide is cloned into an expression vector, the expression vector introduced into a host cell and the protein expressed in the host cell. The protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Many of these techniques are described in detail below.

Accordingly, the present invention provides proteins that consist of the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). The amino acid sequence of such a protein is provided in FIG. 2. A protein consists of an amino acid sequence when the amino acid sequence is the final amino acid sequence of the protein.

The present invention further provides proteins that consist essentially of the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues, for example from about 1 to about 100 or so additional residues, typically from 1 to about 20 additional residues in the final protein.

The present invention further provides proteins that comprise the amino acid sequences provided in FIG. 2 (SEQ ID NO:2), for example, proteins encoded by the transcript/cDNA nucleic acid sequences shown in FIG. 1 (SEQ ID NO:1) and the genomic sequences provided in FIG. 3 (SEQ ID NO:3). A protein comprises an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein can be only the peptide or have additional amino acid molecules, such as amino acid residues (contiguous encoded sequence) that are naturally associated with it or heterologous amino acid residues/peptide sequences. Such a protein can have a few additional amino acid residues or can comprise several hundred or more additional amino acids. The preferred classes of proteins that are comprised of the phosphatase peptides of the present invention are the naturally occurring mature proteins. A brief description of how various types of these proteins can be made/isolated is provided below.

The phosphatase peptides of the present invention can be attached to heterologous sequences to form chimeric or fusion proteins. Such chimeric and fusion proteins comprise a phosphatase peptide operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the phosphatase peptide. “Operatively linked” indicates that the phosphatase peptide and the heterologous protein are fused in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the phosphatase peptide.

In some uses, the fusion protein does not affect the activity of the phosphatase peptide per se. For example, the fusion protein can include, but is not limited to, enzymatic fusion proteins, for example beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions, MYC-tagged, HI-tagged and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate the purification of recombinant phosphatase peptide. In certain host cells (e.g., mammalian host cells), expression and/or secretion of a protein can be increased by using a heterologous signal sequence.

A chimeric or fusion protein can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different protein sequences are ligated together in-frame in accordance with conventional techniques. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence (see Ausubel et al., Current Protocols in Molecular Biology, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A phosphatase peptide-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the phosphatase peptide.

As mentioned above, the present invention also provides and enables obvious variants of the amino acid sequence of the proteins of the present invention, such as naturally occurring mature forms of the peptide, allelic/sequence variants of the peptides, non-naturally occurring recombinantly derived variants of the peptides, and orthologs and paralogs of the peptides. Such variants can readily be generated using art-known techniques in the fields of recombinant nucleic acid technology and protein biochemistry. It is understood, however, that variants exclude any amino acid sequences disclosed prior to the invention.

Such variants can readily be identified/made using molecular techniques and the sequence information disclosed herein. Further, such variants can readily be distinguished from other peptides based on sequence and/or structural homology to the phosphatase peptides of the present invention. The degree of homology/identity present will be based primarily on whether the peptide is a functional variant or non-functional variant, the amount of divergence present in the paralog family and the evolutionary distance between the orthologs.

To determine the percent identity of two amino acid sequences or two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of the length of a reference sequence is aligned for comparison purposes. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid “identity” is equivalent to amino acid or nucleic acid “homology”). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

The comparison of sequences and determination of percent identity and similarity between two sequences can be accomplished using a mathematical algorithm. ( Computational Molecular Biology, Lesk, A. M., ed., Oxford University Press, New York, 1988; Biocomputing: Informatics and Genome Projects , Smith, D. W., ed., Academic Press, New York, 1993; Computer Analysis of Sequence Data, Part 1, Griffin, A. M., and Griffin, H. G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch ( J. Mol. Biol . (48):444-453 (1970)) algorithm which has been incorporated into the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (Devereux, J., et al., Nucleic Acids Res. 12(1):387 (1984)) (available at http://www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E. Myers and W. Miller (CABIOS, 4:11-17 (1989)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4.

The nucleic acid and protein sequences of the present invention can further be used as a “query sequence” to perform a search against sequence databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. ( J. Mol. Biol. 215:403-10 (1990)). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al. ( Nucleic Acids Res. 25(17):3389-3402 (1997)). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used.

Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the peptides of the present invention can readily be identified as having complete sequence identity to one of the phosphatase peptides of the present invention as well as being encoded by the same genetic locus as the phosphatase peptide provided herein. As indicated by the data presented in FIG. 3 , the map position was determined to be on chromosome 12 by ePCR.

Allelic variants of a phosphatase peptide can readily be identified as being a human protein having a high degree (significant) of sequence homology/identity to at least a portion of the phosphatase peptide as well as being encoded by the same genetic locus as the phosphatase peptide provided herein. Genetic locus can readily be determined based on the genomic information provided in FIG. 3 , such as the genomic sequence mapped to the reference human. As indicated by the data presented in FIG. 3 , the map position was determined to be on chromosome 12 by ePCR. As used herein, two proteins (or a region of the proteins) have significant homology when the amino acid sequences are typically at least about 70-80%, 80-90%, and more typically at least about 90-95% or more homologous. A significantly homologous amino acid sequence, according to the present invention, will be encoded by a nucleic acid sequence that will hybridize to a phosphatase peptide encoding nucleic acid molecule under stringent conditions as more fully described below.

FIG. 3 provides information on SNPs that have been identified in a gene encoding the phosphatase protein of the present invention. 82 SNP variants were found, including 6 indels (indicated by a “-”) and 3 SNPs in exons, of which 3 of these cause changes in the amino acid sequence (i.e., nonsynonymous SNPs). SNPs, identified at different nucleotide positions in introns and regions 5′ and 3′ of the ORF, may affect control/regulatory elements.

Paralogs of a phosphatase peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the phosphatase peptide, as being encoded by a gene from humans, and as having similar activity or function. Two proteins will typically be considered paralogs when the amino acid sequences are typically at least about 60% or greater, and more typically at least about 70% or greater homology through a given region or domain. Such paralogs will be encoded by a nucleic acid sequence that will hybridize to a phosphatase peptide encoding nucleic acid molecule under moderate to stringent conditions as more fully described below.

Orthologs of a phosphatase peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of the phosphatase peptide as well as being encoded by a gene from another organism. Preferred orthologs will be isolated from mammals, preferably primates, for the development of human therapeutic targets and agents. Such orthologs will be encoded by a nucleic acid sequence that will hybridize to a phosphatase peptide encoding nucleic acid molecule under moderate to stringent conditions, as more fully described below, depending on the degree of relatedness of the two organisms yielding the proteins.

Non-naturally occurring variants of the phosphatase peptides of the present invention can readily be generated using recombinant techniques. Such variants include, but are not limited to deletions, additions and substitutions in the amino acid sequence of the phosphatase peptide. For example, one class of substitutions are conserved amino acid substitution. Such substitutions are those that substitute a given amino acid in a phosphatase peptide by another amino acid of like characteristics. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and Ile; interchange of the hydroxyl residues Ser and Thr; exchange of the acidic residues Asp and Glu; substitution between the amide residues Asn and Gln; exchange of the basic residues Lys and Arg; and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found in Bowie et al., Science 247:1306-1310 (1990).

Variant phosphatase peptides can be fully functional or can lack function in one or more activities, e.g. ability to bind substrate, ability to dephosphorylate substrate, ability to mediate signaling, etc. Fully functional variants typically contain only conservative variation or variation in non-critical residues or in non-critical regions. FIG. 2 provides the result of protein analysis and can be used to identify critical domains/regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree.

Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, or truncation or a substitution, insertion, inversion, or deletion in a critical residue or critical region.

Amino acids that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis (Cunningham et al., Science 244:1081-1085 (1989)), particularly using the results provided in FIG. 2 . The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as phosphatase activity or in assays such as an in vitro proliferative activity. Sites that are critical for binding partner/substrate binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling (Smith et al., J. Mol. Biol. 224:899-904 (1992); de Vos et al. Science 255:306-312 (1992)).

The present invention further provides fragments of the phosphatase peptides, in addition to proteins and peptides that comprise and consist of such fragments, particularly those comprising the residues identified in FIG. 2 . The fragments to which the invention pertains, however, are not to be construed as encompassing fragments that may be disclosed publicly prior to the present invention.

As used herein, a fragment comprises at least 8, 10, 12, 14, 16, or more contiguous amino acid residues from a phosphatase peptide. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the phosphatase peptide or could be chosen for the ability to perform a function, e.g. bind a substrate or act as an immunogen. Particularly important fragments are biologically active fragments, peptides that are, for example, about 8 or more amino acids in length. Such fragments will typically comprise a domain or motif of the phosphatase peptide, e.g., active site, a transmembrane domain or a substrate-binding domain. Further, possible fragments include, but are not limited to, domain or motif containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well known and readily available to those of skill in the art (e.g., PROSITE analysis). The results of one such analysis are provided in FIG. 2 .

Polypeptides often contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Common modifications that occur naturally in phosphatase peptides are described in basic texts, detailed monographs, and the research literature, and they are well known to those of skill in the art (some of these features are identified in FIG. 2 ).

Known modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.

Such modifications are well known to those of skill in the art and have been described in great detail in the scientific literature. Several particularly common modifications, glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, for instance, are described in most basic texts, such as Proteins—Structure and Molecular Properties, 2nd Ed., T. E. Creighton, W. H. Freeman and Company, New York (1993). Many detailed reviews are available on this subject, such as by Wold, F., Posttranslational Covalent Modification of Proteins , B. C. Johnson, Ed., Academic Press, New York 1-12 (1983); Seifter et al. ( Meth. Enzymol. 182: 626-646 (1990)) and Rattan et al. ( Ann. N.Y. Acad. Sci. 663:48-62 (1992)).

Accordingly, the phosphatase peptides of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature phosphatase peptide is fused with another compound, such as a compound to increase the half-life of the phosphatase peptide, or in which the additional amino acids are fused to the mature phosphatase peptide, such as a leader or secretory sequence or a sequence for purification of the mature phosphatase peptide or a pro-protein sequence.

Protein/Peptide Uses

The proteins of the present invention can be used in substantial and specific assays related to the functional information provided in the Figures; to raise antibodies or to elicit another immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the protein (or its binding partner or ligand) in biological fluids; and as markers for tissues in which the corresponding protein is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state). Where the protein binds or potentially binds to another protein or ligand (such as, for example, in a phosphatase-effector protein interaction or phosphatase-ligand interaction), the protein can be used to identify the binding partner/ligand so as to develop a system to identify inhibitors of the binding interaction. Any or all of these uses are capable of being developed into reagent grade or kit format for commercialization as commercial products.

Methods for performing the uses listed above are well known to those skilled in the art. References disclosing such methods include “Molecular Cloning: A Laboratory Manual”, 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E. F. Fritsch and T. Maniatis eds., 1989, and “Methods in Enzymology: Guide to Molecular Cloning Techniques”, Academic Press, Berger, S. L. and A. R. Kimmel eds., 1987.

The potential uses of the peptides of the present invention are based primarily on the source of the protein as well as the class/action of the protein. For example, phosphatases isolated from humans and their human/mammalian orthologs serve as targets for identifying agents for use in mammalian therapeutic applications, e.g. a human drug, particularly in modulating a biological or pathological response in a cell or tissue that expresses the phosphatase. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta. A large percentage of pharmaceutical agents are being developed that modulate the activity of phosphatase proteins, particularly members of the protein tyrosine phosphatase subfamily (see Background of the Invention). The structural and functional information provided in the Background and Figures provide specific and substantial uses for the molecules of the present invention, particularly in combination with the expression information provided in FIG. 1 . Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. Such uses can readily be determined using the information provided herein, that which is known in the art, and routine experimentation.

The proteins of the present invention (including variants and fragments that may have been disclosed prior to the present invention) are useful for biological assays related to phosphatases that are related to members of the protein tyrosine phosphatase subfamily. Such assays involve any of the known phosphatase functions or activities or properties useful for diagnosis and treatment of phosphatase-related conditions that are specific for the subfamily of phosphatases that the one of the present invention belongs to, particularly in cells and tissues that express the phosphatase. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta.

The proteins of the present invention are also useful in drug screening assays, in cell-based or cell-free systems. Cell-based systems can be native, i.e., cells that normally express the phosphatase, as a biopsy or expanded in cell culture. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. In an alternate embodiment, cell-based assays involve recombinant host cells expressing the phosphatase protein.

The polypeptides can be used to identify compounds that modulate phosphatase activity of the protein in its natural state or an altered form that causes a specific disease or pathology associated with the phosphatase. Both the phosphatases of the present invention and appropriate variants and fragments can be used in high-throughput screens to assay candidate compounds for the ability to bind to the phosphatase. These compounds can be further screened against a functional phosphatase to determine the effect of the compound on the phosphatase activity. Further, these compounds can be tested in animal or invertebrate systems to determine activity/effectiveness. Compounds can be identified that activate (agonist) or inactivate (antagonist) the phosphatase to a desired degree.

Further, the proteins of the present invention can be used to screen a compound for the ability to stimulate or inhibit interaction between the phosphatase protein and a molecule that normally interacts with the phosphatase protein, e.g. a substrate or a component of the signal pathway that the phosphatase protein normally interacts (for example, another phosphatase). Such assays typically include the steps of combining the phosphatase protein with a candidate compound under conditions that allow the phosphatase protein, or fragment, to interact with the target molecule, and to detect the formation of a complex between the protein and the target or to detect the biochemical consequence of the interaction with the phosphatase protein and the target, such as any of the associated effects of signal transduction such as protein phosphorylation, cAMP turnover, and adenylate cyclase activation, etc.

Candidate compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′) 2 , Fab expression library fragments, and epitope-binding fragments of antibodies); and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).

One candidate compound is a soluble fragment of the receptor that competes for substrate binding. Other candidate compounds include mutant phosphatases or appropriate fragments containing mutations that affect phosphatase function and thus compete for substrate. Accordingly, a fragment that competes for substrate, for example with a higher affinity, or a fragment that binds substrate but does not allow release, is encompassed by the invention.

The invention further includes other end point assays to identify compounds that modulate (stimulate or inhibit) phosphatase activity. The assays typically involve an assay of events in the signal transduction pathway that indicate phosphatase activity. Thus, the dephosphorylation of a substrate, activation of a protein, a change in the expression of genes that are up- or down-regulated in response to the phosphatase protein dependent signal cascade can be assayed.

Any of the biological or biochemical functions mediated by the phosphatase can be used as an endpoint assay. These include all of the biochemical or biochemical/biological events described herein, in the references cited herein, incorporated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art or that can be readily identified using the information provided in the Figures, particularly FIG. 2 . Specifically, a biological function of a cell or tissues that expresses the phosphatase can be assayed. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta.

Binding and/or activating compounds can also be screened by using chimeric phosphatase proteins in which the amino terminal extracellular domain, or parts thereof, the entire transmembrane domain or subregions, such as any of the seven transmembrane segments or any of the intracellular or extracellular loops and the carboxy terminal intracellular domain, or parts thereof, can be replaced by heterologous domains or subregions. For example, a substrate-binding region can be used that interacts with a different substrate then that which is recognized by the native phosphatase. Accordingly, a different set of signal transduction components is available as an end-point assay for activation. This allows for assays to be performed in other than the specific host cell from which the phosphatase is derived.

The proteins of the present invention are also useful in competition binding assays in methods designed to discover compounds that interact with the phosphatase (e.g. binding partners and/or ligands). Thus, a compound is exposed to a phosphatase polypeptide under conditions that allow the compound to bind or to otherwise interact with the polypeptide. Soluble phosphatase polypeptide is also added to the mixture. If the test compound interacts with the soluble phosphatase polypeptide, it decreases the amount of complex formed or activity from the phosphatase target. This type of assay is particularly useful in cases in which compounds are sought that interact with specific regions of the phosphatase. Thus, the soluble polypeptide that competes with the target phosphatase region is designed to contain peptide sequences corresponding to the region of interest.

To perform cell free drug screening assays, it is sometimes desirable to immobilize either the phosphatase protein, or fragment, or its target molecule to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay.

Techniques for immobilizing proteins on matrices can be used in the drug screening assays. In one embodiment, a fusion protein can be provided which adds a domain that allows the protein to be bound to a matrix. For example, glutathione-S-transferase fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., 35 S-labeled) and the candidate compound, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads are washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of phosphatase-binding protein found in the bead fraction quantitated from the gel using standard electrophoretic techniques. For example, either the polypeptide or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin using techniques well known in the art. Alternatively, antibodies reactive with the protein but which do not interfere with binding of the protein to its target molecule can be derivatized to the wells of the plate, and the protein trapped in the wells by antibody conjugation. Preparations of a phosphatase-binding protein and a candidate compound are incubated in the phosphatase protein-presenting wells and the amount of complex trapped in the well can be quantitated. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the phosphatase protein target molecule, or which are reactive with phosphatase protein and compete with the target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the target molecule.

Agents that modulate one of the phosphatases of the present invention can be identified using one or more of the above assays, alone or in combination. It is generally preferable to use a cell-based or cell free system first and then confirm activity in an animal or other model system. Such model systems are well known in the art and can readily be employed in this context.

Modulators of phosphatase protein activity identified according to these drug screening assays can be used to treat a subject with a disorder mediated by the kinase pathway, by treating cells or tissues that express the phosphatase. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. These methods of treatment include the steps of administering a modulator of phosphatase activity in a pharmaceutical composition to a subject in need of such treatment, the modulator being identified as described herein.

In yet another aspect of the invention, the phosphatase proteins can be used as “bait proteins” in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al. (1993) Cell 72:223-232; Madura et al. (1993) J. Biol. Chem. 268:12046-12054; Bartel et al. (1993) Biotechniques 14:920-924; Iwabuchi et al. (1993) Oncogene 8:1693-1696; and Brent WO94/10300), to identify other proteins, which bind to or interact with the phosphatase and are involved in phosphatase activity. Such phosphatase-binding proteins are also likely to be involved in the propagation of signals by the phosphatase proteins or phosphatase targets as, for example, downstream elements of a kinase-mediated signaling pathway. Alternatively, such phosphatase-binding proteins are likely to be phosphatase inhibitors.

The two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a phosphatase protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a phosphatase-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the protein which interacts with the phosphatase protein.

This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model. For example, an agent identified as described herein (e.g., a phosphatase-modulating agent, an antisense phosphatase nucleic acid molecule, a phosphatase-specific antibody, or a phosphatase-binding partner) can be used in an animal or other model to determine the efficacy, toxicity, or side effects of treatment with such an agent. Alternatively, an agent identified as described herein can be used in an animal or other model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for treatments as described herein.

The phosphatase proteins of the present invention are also useful to provide a target for diagnosing a disease or predisposition to disease mediated by the peptide. Accordingly, the invention provides methods for detecting the presence, or levels of, the protein (or encoding mRNA) in a cell, tissue, or organism. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. The method involves contacting a biological sample with a compound capable of interacting with the phosphatase protein such that the interaction can be detected. Such an assay can be provided in a single detection format or a multi-detection format such as an antibody chip array.

One agent for detecting a protein in a sample is an antibody capable of selectively binding to protein. A biological sample includes tissues, cells and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject.

The peptides of the present invention also provide targets for diagnosing active protein activity, disease, or predisposition to disease, in a patient having a variant peptide, particularly activities and conditions that are known for other members of the family of proteins to which the present one belongs. Thus, the peptide can be isolated from a biological sample and assayed for the presence of a genetic mutation that results in aberrant peptide. This includes amino acid substitution, deletion, insertion, rearrangement, (as the result of aberrant splicing events), and inappropriate post-translational modification. Analytic methods include altered electrophoretic mobility, altered tryptic peptide digest, altered phosphatase activity in cell-based or cell-free assay, alteration in substrate or antibody-binding pattern, altered isoelectric point, direct amino acid sequencing, and any other of the known assay techniques useful for detecting mutations in a protein. Such an assay can be provided in a single detection format or a multi-detection format such as an antibody chip array.

In vitro techniques for detection of peptide include enzyme linked immunosorbent assays (ELISAs), Western blots, immunoprecipitations and immunofluorescence using a detection reagent, such as an antibody or protein binding agent. Alternatively, the peptide can be detected in vivo in a subject by introducing into the subject a labeled anti-peptide antibody or other types of detection agent. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques. Particularly useful are methods that detect the allelic variant of a peptide expressed in a subject and methods which detect fragments of a peptide in a sample.

The peptides are also useful in pharmacogenomic analysis. Pharmacogenomics deal with clinically significant hereditary variations in the response to drugs due to altered drug disposition and abnormal action in affected persons. See, e.g., Eichelbaum, M. ( Clin. Exp. Pharmacol. Physiol. 23(10-11):983-985 (1996)), and Linder, M. W. ( Clin. Chem. 43(2):254-266 (1997)). The clinical outcomes of these variations result in severe toxicity of therapeutic drugs in certain individuals or therapeutic failure of drugs in certain individuals as a result of individual variation in metabolism. Thus, the genotype of the individual can determine the way a therapeutic compound acts on the body or the way the body metabolizes the compound. Further, the activity of drug metabolizing enzymes effects both the intensity and duration of drug action. Thus, the pharmacogenomics of the individual permit the selection of effective compounds and effective dosages of such compounds for prophylactic or therapeutic treatment based on the individual's genotype. The discovery of genetic polymorphisms in some drug metabolizing enzymes has explained why some patients do not obtain the expected drug effects, show an exaggerated drug effect, or experience serious toxicity from standard drug dosages. Polymorphisms can be expressed in the phenotype of the extensive metabolizer and the phenotype of the poor metabolizer. Accordingly, genetic polymorphism may lead to allelic protein variants of the phosphatase protein in which one or more of the phosphatase functions in one population is different from those in another population. The peptides thus allow a target to ascertain a genetic predisposition that can affect treatment modality. Thus, in a ligand-based treatment, polymorphism may give rise to amino terminal extracellular domains and/or other substrate-binding regions that are more or less active in substrate binding, and phosphatase activation. Accordingly, substrate dosage would necessarily be modified to maximize the therapeutic effect within a given population containing a polymorphism. As an alternative to genotyping, specific polymorphic peptides could be identified.

The peptides are also useful for treating a disorder characterized by an absence of, inappropriate, or unwanted expression of the protein. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. Accordingly, methods for treatment include the use of the phosphatase protein or fragments.

Antibodies

The invention also provides antibodies that selectively bind to one of the peptides of the present invention, a protein comprising such a peptide, as well as variants and fragments thereof. As used herein, an antibody selectively binds a target peptide when it binds the target peptide and does not significantly bind to unrelated proteins. An antibody is still considered to selectively bind a peptide even if it also binds to other proteins that are not substantially homologous with the target peptide so long as such proteins share homology with a fragment or domain of the peptide target of the antibody. In this case, it would be understood that antibody binding to the peptide is still selective despite some degree of cross-reactivity.

As used herein, an antibody is defined in terms consistent with that recognized within the art: they are multi-subunit proteins produced by a mammalian organism in response to an antigen challenge. The antibodies of the present invention include polyclonal antibodies and monoclonal antibodies, as well as fragments of such antibodies, including, but not limited to, Fab or F(ab′) 2 , and Fv fragments.

Many methods are known for generating and/or identifying antibodies to a given target peptide. Several such methods are described by Harlow, Antibodies, Cold Spring Harbor Press, (1989).

In general, to generate antibodies, an isolated peptide is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit or mouse. The full-length protein, an antigenic peptide fragment or a fusion protein can be used. Particularly important fragments are those covering functional domains, such as the domains identified in FIG. 2 , and domain of sequence homology or divergence amongst the family, such as those that can readily be identified using protein alignment methods and as presented in the Figures.

Antibodies are preferably prepared from regions or discrete fragments of the phosphatase proteins. Antibodies can be prepared from any region of the peptide as described herein. However, preferred regions will include those involved in function/activity and/or phosphatase/binding partner interaction. FIG. 2 can be used to identify particularly important regions while sequence alignment can be used to identify conserved and unique sequence fragments.

An antigenic fragment will typically comprise at least 8 contiguous amino acid residues. The antigenic peptide can comprise, however, at least 10, 12, 14, 16 or more amino acid residues. Such fragments can be selected on a physical property, such as fragments correspond to regions that are located on the surface of the protein, e.g., hydrophilic regions or can be selected based on sequence uniqueness (see FIG. 2 ).

Detection on an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include 125 I, 131 I, 35 S or 3 H.

Antibody Uses

The antibodies can be used to isolate one of the proteins of the present invention by standard techniques, such as affinity chromatography or immunoprecipitation. The antibodies can facilitate the purification of the natural protein from cells and recombinantly produced protein expressed in host cells. In addition, such antibodies are useful to detect the presence of one of the proteins of the present invention in cells or tissues to determine the pattern of expression of the protein among various tissues in an organism and over the course of normal development. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta. Further, such antibodies can be used to detect protein in situ, in vitro, or in a cell lysate or supernatant in order to evaluate the abundance and pattern of expression. Also, such antibodies can be used to assess abnormal tissue distribution or abnormal expression during development or progression of a biological condition. Antibody detection of circulating fragments of the full length protein can be used to identify turnover.

Further, the antibodies can be used to assess expression in disease states such as in active stages of the disease or in an individual with a predisposition toward disease related to the protein's function. When a disorder is caused by an inappropriate tissue distribution, developmental expression, level of expression of the protein, or expressed/processed form, the antibody can be prepared against the normal protein. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. If a disorder is characterized by a specific mutation in the protein, antibodies specific for this mutant protein can be used to assay for the presence of the specific mutant protein.

The antibodies can also be used to assess normal and aberrant subcellular localization of cells in the various tissues in an organism. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality. Accordingly, where treatment is ultimately aimed at correcting expression level or the presence of aberrant sequence and aberrant tissue distribution or developmental expression, antibodies directed against the protein or relevant fragments can be used to monitor therapeutic efficacy.

Additionally, antibodies are useful in pharmacogenomic analysis. Thus, antibodies prepared against polymorphic proteins can be used to identify individuals that require modified treatment modalities. The antibodies are also useful as diagnostic tools as an immunological marker for aberrant protein analyzed by electrophoretic mobility, isoelectric point, tryptic peptide digest, and other physical assays known to those in the art.

The antibodies are also useful for tissue typing. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. Thus, where a specific protein has been correlated with expression in a specific tissue, antibodies that are specific for this protein can be used to identify a tissue type.

The antibodies are also useful for inhibiting protein function, for example, blocking the binding of the phosphatase peptide to a binding partner such as a substrate. These uses can also be applied in a therapeutic context in which treatment involves inhibiting the protein's function. An antibody can be used, for example, to block binding, thus modulating (agonizing or antagonizing) the peptides activity. Antibodies can be prepared against specific fragments containing sites required for function or against intact protein that is associated with a cell or cell membrane. See FIG. 2 for structural information relating to the proteins of the present invention.

The invention also encompasses kits for using antibodies to detect the presence of a protein in a biological sample. The kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting protein in a biological sample; means for determining the amount of protein in the sample; means for comparing the amount of protein in the sample with a standard; and instructions for use. Such a kit can be supplied to detect a single protein or epitope or can be configured to detect one of a multitude of epitopes, such as in an antibody detection array. Arrays are described in detail below for nuleic acid arrays and similar methods have been developed for antibody arrays.

Nucleic Acid Molecules

The present invention further provides isolated nucleic acid molecules that encode a phosphatase peptide or protein of the present invention (cDNA, transcript and genomic sequence). Such nucleic acid molecules will consist of, consist essentially of, or comprise a nucleotide sequence that encodes one of the phosphatase peptides of the present invention, an allelic variant thereof, or an ortholog or paralog thereof.

As used herein, an “isolated” nucleic acid molecule is one that is separated from other nucleic acid present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. However, there can be some flanking nucleotide sequences, for example up to about 5KB, 4KB, 3KB, 2KB, or 1KB or less, particularly contiguous peptide encoding sequences and peptide encoding sequences within the same gene but separated by introns in the genomic sequence. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences such that it can be subjected to the specific manipulations described herein such as recombinant expression, preparation of probes and primers, and other uses specific to the nucleic acid sequences.

Moreover, an “isolated” nucleic acid molecule, such as a transcript/cDNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. However, the nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered isolated.

For example, recombinant DNA molecules contained in a vector are considered isolated. Further examples of isolated DNA molecules include recombinant DNA molecules maintained in heterologous host cells or purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.

Accordingly, the present invention provides nucleic acid molecules that consist of the nucleotide sequence shown in FIG. 1 or 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2 , SEQ ID NO:2. A nucleic acid molecule consists of a nucleotide sequence when the nucleotide sequence is the complete nucleotide sequence of the nucleic acid molecule.

The present invention further provides nucleic acid molecules that consist essentially of the nucleotide sequence shown in FIG. 1 or 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2 , SEQ ID NO:2. A nucleic acid molecule consists essentially of a nucleotide sequence when such a nucleotide sequence is present with only a few additional nucleic acid residues in the final nucleic acid molecule.

The present invention further provides nucleic acid molecules that comprise the nucleotide sequences shown in FIG. 1 or 3 (SEQ ID NO:1, transcript sequence and SEQ ID NO:3, genomic sequence), or any nucleic acid molecule that encodes the protein provided in FIG. 2 , SEQ ID NO:2. A nucleic acid molecule comprises a nucleotide sequence when the nucleotide sequence is at least part of the final nucleotide sequence of the nucleic acid molecule. In such a fashion, the nucleic acid molecule can be only the nucleotide sequence or have additional nucleic acid residues, such as nucleic acid residues that are naturally associated with it or heterologous nucleotide sequences. Such a nucleic acid molecule can have a few additional nucleotides or can comprises several hundred or more additional nucleotides. A brief description of how various types of these nucleic acid molecules can be readily made/isolated is provided below.

In FIGS. 1 and 3 , both coding and non-coding sequences are provided. Because of the source of the present invention, humans genomic sequence ( FIG. 3 ) and cDNA/transcript sequences (FIG. 1 ), the nucleic acid molecules in the Figures will contain genomic intronic sequences, 5′ and 3′ non-coding sequences, gene regulatory regions and non-coding intergenic sequences. In general such sequence features are either noted in FIGS. 1 and 3 or can readily be identified using computational tools known in the art. As discussed below, some of the non-coding regions, particularly gene regulatory elements such as promoters, are useful for a variety of purposes, e.g. control of heterologous gene expression, target for identifying gene activity modulating compounds, and are particularly claimed as fragments of the genomic sequence provided herein.

The isolated nucleic acid molecules can encode the mature protein plus additional amino or carboxyl-terminal amino acids, or amino acids interior to the mature peptide (when the mature form has more than one peptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life or facilitate manipulation of a protein for assay or production, among other things. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes.

As mentioned above, the isolated nucleic acid molecules include, but are not limited to, the sequence encoding the phosphatase peptide alone, the sequence encoding the mature peptide and additional coding sequences, such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), the sequence encoding the mature peptide, with or without the additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5′ and 3′ sequences such as transcribed but non-translated sequences that play a role in transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding and stability of mRNA. In addition, the nucleic acid molecule may be fused to a marker sequence encoding, for example, a peptide that facilitates purification.

Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA obtained by cloning or produced by chemical synthetic techniques or by a combination thereof. The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the non-coding strand (anti-sense strand).

The invention further provides nucleic acid molecules that encode fragments of the peptides of the present invention as well as nucleic acid molecules that encode obvious variants of the phosphatase proteins of the present invention that are described above. Such nucleic acid molecules may be naturally occurring, such as allelic variants (same locus), paralogs (different locus), and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Such non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, as discussed above, the variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions.

The present invention further provides non-coding fragments of the nucleic acid molecules provided in FIGS. 1 and 3 . Preferred non-coding fragments include, but are not limited to, promoter sequences, enhancer sequences, gene modulating sequences and gene termination sequences. Such fragments are useful in controlling heterologous gene expression and in developing screens to identify gene-modulating agents. A promoter can readily be identified as being 5′ to the ATG start site in the genomic sequence provided in FIG. 3 .

A fragment comprises a contiguous nucleotide sequence greater than 12 or more nucleotides. Further, a fragment could at least 30, 40, 50, 100, 250 or 500 nucleotides in length. The length of the fragment will be based on its intended use. For example, the fragment can encode epitope bearing regions of the peptide, or can be useful as DNA probes and primers. Such fragments can be isolated using the known nucleotide sequence to synthesize an oligonucleotide probe. A labeled probe can then be used to screen a cDNA library, genomic DNA library, or mRNA to isolate nucleic acid corresponding to the coding region. Further, primers can be used in PCR reactions to clone specific regions of gene.

A probe/primer typically comprises substantially a purified oligonucleotide or oligonucleotide pair. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, 20, 25, 40, 50 or more consecutive nucleotides.

Orthologs, homologs, and allelic variants can be identified using methods well known in the art. As described in the Peptide Section, these variants comprise a nucleotide sequence encoding a peptide that is typically 60-70%, 70-80%, 80-90%, and more typically at least about 90-95% or more homologous to the nucleotide sequence shown in the Figure sheets or a fragment of this sequence. Such nucleic acid molecules can readily be identified as being able to hybridize under moderate to stringent conditions, to the nucleotide sequence shown in the Figure sheets or a fragment of the sequence. Allelic variants can readily be determined by genetic locus of the encoding gene. As indicated by the data presented in FIG. 3 , the map position was determined to be on chromosome 12 by ePCR.

FIG. 3 provides information on SNPs that have been identified in a gene encoding the phosphatase protein of the present invention. 82 SNP variants were found, including 6 indels (indicated by a “-”) and 3 SNPs in exons, of which 3 of these cause changes in the amino acid sequence (i.e., nonsynonymous SNPs). SNPs, identified at different nucleotide positions in introns and regions 5′ and 3′ of the ORF, may affect control/regulatory elements.

As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences encoding a peptide at least 60-70% homologous to each other typically remain hybridized to each other. The conditions can be such that sequences at least about 60%, at least about 70%, or at least about 80% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology , John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. One example of stringent hybridization conditions are hybridization in 6×sodium chloride/sodium citrate (SSC) at about 45C, followed by one or more washes in 0.2×SSC, 0.1% SDS at 50-65C. Examples of moderate to low stringency hybridization conditions are well known in the art.

Nucleic Acid Molecule Uses

The nucleic acid molecules of the present invention are useful for probes, primers, chemical intermediates, and in biological assays. The nucleic acid molecules are useful as a hybridization probe for messenger RNA, transcript/cDNA and genomic DNA to isolate full-length cDNA and genomic clones encoding the peptide described in FIG. 2 and to isolate cDNA and genomic clones that correspond to variants (alleles, orthologs, etc.) producing the same or related peptides shown in FIG. 2. 82 SNPs, including 6 indels, have been identified in the gene encoding the phosphatase protein provided by the present invention and are given in FIG. 3 .

The probe can correspond to any sequence along the entire length of the nucleic acid molecules provided in the Figures. Accordingly, it could be derived from 5′ noncoding regions, the coding region, and 3′ noncoding regions. However, as discussed, fragments are not to be construed as encompassing fragments disclosed prior to the present invention.

The nucleic acid molecules are also useful as primers for PCR to amplify any given region of a nucleic acid molecule and are useful to synthesize antisense molecules of desired length and sequence.

The nucleic acid molecules are also useful for constructing recombinant vectors. Such vectors include expression vectors that express a portion of, or all of, the peptide sequences. Vectors also include insertion vectors, used to integrate into another nucleic acid molecule sequence, such as into the cellular genome, to alter in situ expression of a gene and/or gene product. For example, an endogenous coding sequence can be replaced via homologous recombination with all or part of the coding region containing one or more specifically introduced mutations.

The nucleic acid molecules are also useful for expressing antigenic portions of the proteins.

The nucleic acid molecules are also useful as probes for determining the chromosomal positions of the nucleic acid molecules by means of in situ hybridization methods. As indicated by the data presented in FIG. 3 , the map position was determined to be on chromosome 12 by ePCR.

The nucleic acid molecules are also useful in making vectors containing the gene regulatory regions of the nucleic acid molecules of the present invention.

The nucleic acid molecules are also useful for designing ribozymes corresponding to all, or a part, of the mRNA produced from the nucleic acid molecules described herein.

The nucleic acid molecules are also useful for making vectors that express part, or all, of the peptides.

The nucleic acid molecules are also useful for constructing host cells expressing a part, or all, of the nucleic acid molecules and peptides.

The nucleic acid molecules are also useful for constructing transgenic animals expressing all, or a part, of the nucleic acid molecules and peptides.

The nucleic acid molecules are also useful as hybridization probes for determining the presence, level, form and distribution of nucleic acid expression. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta. Accordingly, the probes can be used to detect the presence of, or to determine levels of, a specific nucleic acid molecule in cells, tissues, and in organisms. The nucleic acid whose level is determined can be DNA or RNA. Accordingly, probes corresponding to the peptides described herein can be used to assess expression and/or gene copy number in a given cell, tissue, or organism. These uses are relevant for diagnosis of disorders involving an increase or decrease in phosphatase protein expression relative to normal results.

In vitro techniques for detection of mRNA include Northern hybridizations and in situ hybridizations. In vitro techniques for detecting DNA includes Southern hybridizations and in situ hybridization.

Probes can be used as a part of a diagnostic test kit for identifying cells or tissues that express a phosphatase protein, such as by measuring a level of a phosphatase-encoding nucleic acid in a sample of cells from a subject e.g., mRNA or genomic DNA, or determining if a phosphatase gene has been mutated. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta.

Nucleic acid expression assays are useful for drug screening to identify compounds that modulate phosphatase nucleic acid expression.

The invention thus provides a method for identifying a compound that can be used to treat a disorder associated with nucleic acid expression of the phosphatase gene, particularly biological and pathological processes that are mediated by the phosphatase in cells and tissues that express it. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta. The method typically includes assaying the ability of the compound to modulate the expression of the phosphatase nucleic acid and thus identifying a compound that can be used to treat a disorder characterized by undesired phosphatase nucleic acid expression. The assays can be performed in cell-based and cell-free systems. Cell-based assays include cells naturally expressing the phosphatase nucleic acid or recombinant cells genetically engineered to express specific nucleic acid sequences.

The assay for phosphatase nucleic acid expression can involve direct assay of nucleic acid levels, such as mRNA levels, or on collateral compounds involved in the signal pathway. Further, the expression of genes that are up- or down-regulated in response to the phosphatase protein signal pathway can also be assayed. In this embodiment the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase.

Thus, modulators of phosphatase gene expression can be identified in a method wherein a cell is contacted with a candidate compound and the expression of mRNA determined. The level of expression of phosphatase mRNA in the presence of the candidate compound is compared to the level of expression of phosphatase mRNA in the absence of the candidate compound. The candidate compound can then be identified as a modulator of nucleic acid expression based on this comparison and be used, for example to treat a disorder characterized by aberrant nucleic acid expression. When expression of mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of nucleic acid expression. When nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of nucleic acid expression.

The invention further provides methods of treatment, with the nucleic acid as a target, using a compound identified through drug screening as a gene modulator to modulate phosphatase nucleic acid expression in cells and tissues that express the phosphatase. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta. Modulation includes both up-regulation (i.e. activation or agonization) or down-regulation (suppression or antagonization) or nucleic acid expression.

Alternatively, a modulator for phosphatase nucleic acid expression can be a small molecule or drug identified using the screening assays described herein as long as the drug or small molecule inhibits the phosphatase nucleic acid expression in the cells and tissues that express the protein. Experimental data as provided in FIG. 1 indicates expression in colon adenocarcinoma and placenta.

The nucleic acid molecules are also useful for monitoring the effectiveness of modulating compounds on the expression or activity of the phosphatase gene in clinical trials or in a treatment regimen. Thus, the gene expression pattern can serve as a barometer for the continuing effectiveness of treatment with the compound, particularly with compounds to which a patient can develop resistance. The gene expression pattern can also serve as a marker indicative of a physiological response of the affected cells to the compound. Accordingly, such monitoring would allow either increased administration of the compound or the administration of alternative compounds to which the patient has not become resistant. Similarly, if the level of nucleic acid expression falls below a desirable level, administration of the compound could be commensurately decreased.

The nucleic acid molecules are also useful in diagnostic assays for qualitative changes in phosphatase nucleic acid expression, and particularly in qualitative changes that lead to pathology. The nucleic acid molecules can be used to detect mutations in phosphatase genes and gene expression products such as mRNA. The nucleic acid molecules can be used as hybridization probes to detect naturally occurring genetic mutations in the phosphatase gene and thereby to determine whether a subject with the mutation is at risk for a disorder caused by the mutation. Mutations include deletion, addition, or substitution of one or more nucleotides in the gene, chromosomal rearrangement, such as inversion or transposition, modification of genomic DNA, such as aberrant methylation patterns or changes in gene copy number, such as amplification. Detection of a mutated form of the phosphatase gene associated with a dysfunction provides a diagnostic tool for an active disease or susceptibility to disease when the disease results from overexpression, underexpression, or altered expression of a phosphatase protein.

Individuals carrying mutations in the phosphatase gene can be detected at the nucleic acid level by a variety of techniques. FIG. 3 provides information on SNPs that have been identified in a gene encoding the phosphatase protein of the present invention. 82 SNP variants were found, including 6 indels (indicated by a “-”) and 3 SNPs in exons, of which 3 of these cause changes in the amino acid sequence (i.e., nonsynonymous SNPs). SNPs, identified at different nucleotide positions in introns and regions 5′ and 3′ of the ORF, may affect control/regulatory elements. As indicated by the data presented in FIG. 3 , the map position was determined to be on chromosome 12 by ePCR. Genomic DNA can be analyzed directly or can be amplified by using PCR prior to analysis. RNA or cDNA can be used in the same way. In some uses, detection of the mutation involves the use of a probe/primer in a polymerase chain reaction (PCR) (see, e.g. U.S. Pat. Nos. 4,683,195 and 4,683,202), such as anchor PCR or RACE PCR, or, alternatively, in a ligation chain reaction (LCR) (see, e.g., Landegran et al., Science 241:1077-1080 (1988); and Nakazawa et al., PNAS 91:360-364 (1994)), the latter of which can be particularly useful for detecting point mutations in the gene (see Abravaya et al., Nucleic Acids Res. 23:675-682 (1995)). This method can include the steps of collecting a sample of cells from a patient, isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, contacting the nucleic acid sample with one or more primers which specifically hybridize to a gene under conditions such that hybridization and amplification of the gene (if present) occurs, and detecting the presence or absence of an amplification product, or detecting the size of the amplification product and comparing the length to a control sample. Deletions and insertions can be detected by a change in size of the amplified product compared to the normal genotype. Point mutations can be identified by hybridizing amplified DNA to normal RNA or antisense DNA sequences.

Alternatively, mutations in a phosphatase gene can be directly identified, for example, by alterations in restriction enzyme digestion patterns determined by gel electrophoresis.

Further, sequence-specific ribozymes (U.S. Pat. No. 5,498,531) can be used to score for the presence of specific mutations by development or loss of a ribozyme cleavage site. Perfectly matched sequences can be distinguished from mismatched sequences by nuclease cleavage digestion assays or by differences in melting temperature.

Sequence changes at specific locations can also be assessed by nuclease protection assays such as RNase and S1 protection or the chemical cleavage method. Furthermore, sequence differences between a mutant phosphatase gene and a wild-type gene can be determined by direct DNA sequencing. A variety of automated sequencing procedures can be utilized when performing the diagnostic assays (Naeve, C. W., (1995) Biotechniques 19:448), including sequencing by mass spectrometry (see, e.g., PCT International Publication No. WO94/16101; Cohen et al, Adv. Chromatogr. 36:127-162 (1996); and Griffin et al., Appl. Biochem. Biotechnol. 38:147-159 (1993)).

Other methods for detecting mutations in the gene include methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA duplexes (Myers et al., Science 230:1242 (1985)); Cotton et al., PNAS 85:4397 (1988); Saleeba et al., Meth. Enzymol. 217:286-295 (1992)), electrophoretic mobility of mutant and wild type nucleic acid is compared (Orita et al., PNAS 86:2766 (1989); Cotton et al., Mutat. Res. 285:125-144 (1993); and Hayashi et al., Genet. Anal. Tech. Appl. 9:73-79 (1992)), and movement of mutant or wild-type fragments in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (Myers et al., Nature 313:495 (1985)). Examples of other techniques for detecting point mutations include selective oligonucleotide hybridization, selective amplification, and selective primer extension.

The nucleic acid molecules are also useful for testing an individual for a genotype that while not necessarily causing the disease, nevertheless affects the treatment modality. Thus, the nucleic acid molecules can be used to study the relationship between an individual's genotype and the individual's response to a compound used for treatment (pharmacogenomic relationship). Accordingly, the nucleic acid molecules described herein can be used to assess the mutation content of the phosphatase gene in an individual in order to select an appropriate compound or dosage regimen for treatment. FIG. 3 provides information on SNPs that have been identified in a gene encoding the phosphatase protein of the present invention. 82 SNP variants were found, including 6 indels (indicated by a “-”) and 3 SNPs in exons, of which 3 of these cause changes in the amino acid sequence (i.e., nonsynonymous SNPs). SNPs, identified at different nucleotide positions in introns and regions 5′ and 3′ of the ORF, may affect control/regulatory elements.

Thus nucleic acid molecules displaying genetic variations that affect treatment provide a diagnostic target that can be used to tailor treatment in an individual. Accordingly, the production of recombinant cells and animals containing these polymorphisms allow effective clinical design of treatment compounds and dosage regimens.

The nucleic acid molecules are thus useful as antisense constructs to control phosphatase gene expression in cells, tissues, and organisms. A DNA antisense nucleic acid molecule is designed to be complementary to a region of the gene involved in transcription, preventing transcription and hence production of phosphatase protein. An antisense RNA or DNA nucleic acid molecule would hybridize to the mRNA and thus block translation of mRNA into phosphatase protein.

Alternatively, a class of antisense molecules can be used to inactivate mRNA in order to decrease expression of phosphatase nucleic acid. Accordingly, these molecules can treat a disorder characterized by abnormal or undesired phosphatase nucleic acid expression. This technique involves cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Possible regions include coding regions and particularly coding regions corresponding to the catalytic and other functional activities of the phosphatase protein, such as substrate binding.

The nucleic acid molecules also provide vectors for gene therapy in patients containing cells that are aberrant in phosphatase gene expression. Thus, recombinant cells, which include the patient's cells that have been engineered ex vivo and returned to the patient, are introduced into an individual where the cells produce the desired phosphatase protein to treat the individual.

The invention also encompasses kits for detecting the presence of a phosphatase nucleic acid in a biological sample. Experimental data as provided in FIG. 1 indicates that phosphatase proteins of the present invention are expressed in the colon adenocarcinoma detected by a virtual northern blot. In addition, PCR-based tissue screening panel indicates expression in and placenta. For example, the kit can comprise reagents such as a labeled or labelable nucleic acid or agent capable of detecting phosphatase nucleic acid in a biological sample; means for determining the amount of phosphatase nucleic acid in the sample; and means for comparing the amount of phosphatase nucleic acid in the sample with a standard. The compound or agent can be packaged in a suitable container. The kit can further comprise instructions for using the kit to detect phosphatase protein mRNA or DNA.

Nucleic Acid Arrays

The present invention further provides nucleic acid detection kits, such as arrays or microarrays of nucleic acid molecules that are based on the sequence information provided in FIGS. 1 and 3 (SEQ ID NOS:1 and 3).

As used herein “Arrays” or “Microarrays” refers to an array of distinct polynucleotides or oligonucleotides synthesized on a substrate, such as paper, nylon or other type of membrane, filter, chip, glass slide, or any other suitable solid support. In one embodiment, the microarray is prepared and used according to the methods described in U.S. Pat. No. 5,837,832, Chee et al., PCT application WO95/11995 (Chee et al.), Lockhart, D. J. et al. (1996; Nat. Biotech. 14: 1675-1680) and Schena, M. et al. (1996; Proc. Natl. Acad. Sci. 93: 10614-10619), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., U.S. Pat. No. 5,807,522.

The microarray or detection kit is preferably composed of a large number of unique, single-stranded nucleic acid sequences, usually either synthetic antisense oligonucleotides or fragments of cDNAs, fixed to a solid support. The oligonucleotides are preferably about 6-60 nucleotides in length, more preferably 15-30 nucleotides in length, and most preferably about 20-25 nucleotides in length. For a certain type of microarray or detection kit, it may be preferable to use oligonucleotides that are only 7-20 nucleotides in length. The microarray or detection kit may contain oligonucleotides that cover the known 5′, or 3′, sequence, sequential oligonucleotides which cover the full length sequence; or unique oligonucleotides selected from particular areas along the length of the sequence. Polynucleotides used in the microarray or detection kit may be oligonucleotides that are specific to a gene or genes of interest.

In order to produce oligonucleotides to a known sequence for a microarray or detection kit, the gene(s) of interest (or an ORF identified from the contigs of the present invention) is typically examined using a computer algorithm which starts at the 5′ or at the 3′ end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene, have a GC content within a range suitable for hybridization, and lack predicted secondary structure that may interfere with hybridization. In certain situations it may be appropriate to use pairs of oligonucleotides on a microarray or detection kit. The “pairs” will be identical, except for one nucleotide that preferably is located in the center of the sequence. The second oligonucleotide in the pair (mismatched by one) serves as a control. The number of oligonucleotide pairs may range from two to one million. The oligomers are synthesized at designated areas on a substrate using a light-directed chemical process. The substrate may be paper, nylon or other type of membrane, filter, chip, glass slide or any other suitable solid support.

In another aspect, an oligonucleotide may be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application WO95/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a “gridded” array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more oligonucleotides, or any other number between two and one million which lends itself to the efficient use of commercially available instrumentation.

In order to conduct sample analysis using a microarray or detection kit, the RNA or DNA from a biological sample is made into hybridization probes. The mRNA is isolated, and cDNA is produced and used as a template to make antisense RNA (aRNA). The aRNA is amplified in the presence of fluorescent nucleotides, and labeled probes are incubated with the microarray or detection kit so that the probe sequences hybridize to complementary oligonucleotides of the microarray or detection kit. Incubation conditions are adjusted so that hybridization occurs with precise complementary matches or with various degrees of less complementarity. After removal of nonhybridized probes, a scanner is used to determine the levels and patterns of fluorescence. The scanned images are examined to determine degree of complementarity and the relative abundance of each oligonucleotide sequence on the microarray or detection kit. The biological samples may be obtained from any bodily fluids (such as blood, urine, saliva, phlegm, gastric juices, etc.), cultured cells, biopsies, or other tissue preparations. A detection system may be used to measure the absence, presence, and amount of hybridization for all of the distinct sequences simultaneously. This data may be used for large-scale correlation studies on the sequences, expression patterns, mutations, variants, or polymorphisms among samples.

Using such arrays, the present invention provides methods to identify the expression of the phosphatase proteins/peptides of the present invention. In detail, such methods comprise incubating a test sample with one or more nucleic acid molecules and assaying for binding of the nucleic acid molecule with components within the test sample. Such assays will typically involve arrays comprising many genes, at least one of which is a gene of the present invention and or alleles of the phosphatase gene of the present invention. FIG. 3 provides information on SNPs that have been identified in a gene encoding the phosphatase protein of the present invention. 82 SNP variants were found, including 6 indels (indicated by a “-”) and 3 SNPs in exons, of which 3 of these cause changes in the amino acid sequence (i.e., nonsynonymous SNPs). SNPs, identified at different nucleotide positions in introns and regions 5′ and 3′ of the ORF, may affect control/regulatory elements.

Conditions for incubating a nucleic acid molecule with a test sample vary. Incubation conditions depend on the format employed in the assay, the detection methods employed, and the type and nature of the nucleic acid molecule used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification or array assay formats can readily be adapted to employ the novel fragments of the Human genome disclosed herein. Examples of such assays can be found in Chard, T, An Introduction to Radioimmunoassay and Related Techniques , Elsevier Science Publishers, Amsterdam, The Netherlands (1986); Bullock, G. R. et al., Techniques in Immunocytochemistry , Academic Press, Orlando, Fla. Vol. 1 (1 982), Vol. 2 (1983), Vol. 3 (1985); Tijssen, P., Practice and Theory of Enzyme Immunoassays: Laboratory Techniques in Biochemistry and Molecular Biology , Elsevier Science Publishers, Amsterdam, The Netherlands (1985).

The test samples of the present invention include cells, protein or membrane extracts of cells. The test sample used in the above-described method will vary based on the assay format, nature of the detection method and the tissues, cells or extracts used as the sample to be assayed. Methods for preparing nucleic acid extracts or of cells are well known in the art and can be readily be adapted in order to obtain a sample that is compatible with the system utilized.

In another embodiment of the present invention, kits are provided which contain the necessary reagents to carry out the assays of the present invention.

Specifically, the invention provides a compartmentalized kit to receive, in close confinement, one or more containers which comprises: (a) a first container comprising one of the nucleic acid molecules that can bind to a fragment of the Human genome disclosed herein; and (b) one or more other containers comprising one or more of the following: wash reagents, reagents capable of detecting presence of a bound nucleic acid.

In detail, a compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allows one to efficiently transfer reagents from one compartment to another compartment such that the samples and reagents are not cross-contaminated, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another. Such containers will include a container which will accept the test sample, a container which contains the nucleic acid probe, containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and containers which contain the reagents used to detect the bound probe. One skilled in the art will readily recognize that the previously unidentified phosphatase gene of the present invention can be routinely identified using the sequence information disclosed herein can be readily incorporated into one of the established kit formats which are well known in the art, particularly expression arrays.

Vectors/Host Cells

The invention also provides vectors containing the nucleic acid molecules described herein. The term “vector” refers to a vehicle, preferably a nucleic acid molecule, which can transport the nucleic acid molecules. When the vector is a nucleic acid molecule, the nucleic acid molecules are covalently linked to the vector nucleic acid. With this aspect of the invention, the vector includes a plasmid, single or double stranded phage, a single or double stranded RNA or DNA viral vector, or artificial chromosome, such as a BAC, PAC, YAC, OR MAC.

A vector can be maintained in the host cell as an extrachromosomal element where it replicates and produces additional copies of the nucleic acid molecules. Alternatively, the vector may integrate into the host cell genome and produce additional copies of the nucleic acid molecules when the host cell replicates.

The invention provides vectors for the maintenance (cloning vectors) or vectors for expression (expression vectors) of the nucleic acid molecules. The vectors can function in prokaryotic or eukaryotic cells or in both (shuttle vectors).

Expression vectors contain cis-acting regulatory regions that are operably linked in the vector to the nucleic acid molecules such that transcription of the nucleic acid molecules is allowed in a host cell. The nucleic acid molecules can be introduced into the host cell with a separate nucleic acid molecule capable of affecting transcription. Thus, the second nucleic acid molecule may provide a trans-acting factor interacting with the cis-regulatory control region to allow transcription of the nucleic acid molecules from the vector. Alternatively, a trans-acting factor may be supplied by the host cell. Finally, a trans-acting factor can be produced from the vector itself. It is understood, however, that in some embodiments, transcription and/or translation of the nucleic acid molecules can occur in a cell-free system.

The regulatory sequence to which the nucleic acid molecules described herein can be operably linked include promoters for directing mRNA transcription. These include, but are not limited to, the left promoter from bacteriophage λ, the lac, TRP, and TAC promoters from E. coli , the early and late promoters from SV40, the CMV immediate early promoter, the adenovirus early and late promoters, and retrovirus long-terminal repeats.

In addition to control regions that promote transcription, expression vectors may also include regions that modulate transcription, such as repressor binding sites and enhancers. Examples include the SV40 enhancer, the cytomegalovirus immediate early enhancer, polyoma enhancer, adenovirus enhancers, and retrovirus LTR enhancers.

In addition to containing sites for transcription initiation and control, expression vectors can also contain sequences necessary for transcription termination and, in the transcribed region a ribosome binding site for translation. Other regulatory control elements for expression include initiation and termination codons as well as polyadenylation signals. The person of ordinary skill in the art would be aware of the numerous regulatory sequences that are useful in expression vectors. Such regulatory sequences are described, for example, in Sambrook et al., Molecular Cloning: A Laboratory Manual. 2 nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., (1989).

A variety of expression vectors can be used to express a nucleic acid molecule. Such vectors include chromosomal, episomal, and virus-derived vectors, for example vectors derived from bacterial plasmids, from bacteriophage, from yeast episomes, from yeast chromosomal elements, including yeast artificial chromosomes, from viruses such as baculoviruses, papovaviruses such as SV40, Vaccinia viruses, adenoviruses, poxviruses, pseudorabies viruses, and retroviruses. Vectors may also be derived from combinations of these sources such as those derived from plasmid and bacteriophage genetic elements, e.g. cosmids and phagemids. Appropriate cloning and expression vectors for prokaryotic and eukaryotic hosts are described in Sambrook et al., Molecular Cloning: A Laboratory Manual. 2 nd. ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., (1989).

The regulatory sequence may provide constitutive expression in one or more host cells (i.e. tissue specific) or may provide for inducible expression in one or more cell types such as by temperature, nutrient additive, or exogenous factor such as a hormone or other ligand. A variety of vectors providing for constitutive and inducible expression in prokaryotic and eukaryotic hosts are well known to those of ordinary skill in the art.

The nucleic acid molecules can be inserted into the vector nucleic acid by well-known methodology. Generally, the DNA sequence that will ultimately be expressed is joined to an expression vector by cleaving the DNA sequence and the expression vector with one or more restriction enzymes and then ligating the fragments together. Procedures for restriction enzyme digestion and ligation are well known to those of ordinary skill in the art.

The vector containing the appropriate nucleic acid molecule can be introduced into an appropriate host cell for propagation or expression using well-known techniques. Bacterial cells include, but are not limited to, E. coli , Streptomyces, and Salmonella typhimurium . Eukaryotic cells include, but are not limited to, yeast, insect cells such as Drosophila, animal cells such as COS and CHO cells, and plant cells.

As described herein, it may be desirable to express the peptide as a fusion protein. Accordingly, the invention provides fusion vectors that allow for the production of the peptides. Fusion vectors can increase the expression of a recombinant protein, increase the solubility of the recombinant protein, and aid in the purification of the protein by acting for example as a ligand for affinity purification. A proteolytic cleavage site may be introduced at the junction of the fusion moiety so that the desired peptide can ultimately be separated from the fusion moiety. Proteolytic enzymes include, but are not limited to, factor Xa, thrombin, and enterophosphatase. Typical fusion expression vectors include pGEX (Smith et al., Gene 67:31-40 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., Gene 69:301-315 (1988)) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185:60-89 (1990)).

Recombinant protein expression can be maximized in host bacteria by providing a genetic background wherein the host cell has an impaired capacity to proteolytically cleave the recombinant protein. (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990)119-128). Alternatively, the sequence of the nucleic acid molecule of interest can be altered to provide preferential codon usage for a specific host cell, for example E. coli . (Wada et al., Nucleic Acids Res. 20:2111-2118 (1992)).

The nucleic acid molecules can also be expressed by expression vectors that are operative in yeast. Examples of vectors for expression in yeast e.g., S. cerevisiae include pYepSec1 (Baldari, et al., EMBO J. 6:229-234 (1987)), pMFa (Kurjan et al., Cell 30:933-943(1982) pJRY88 (Schultz et al., Gene 54:113-123 (1987)), and pYES2 (Invitrogen Corporation, San Diego, Calif.).

The nucleic acid molecules can also be expressed in insect cells using, for example, baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf9 cells) include the pAc series (Smith et al., Mol. Cell Biol. 3:2156-2165 (1983)) and the pVL series (Lucklow et al., Virology 170:31-39 (1989)).

In certain embodiments of the invention, the nucleic acid molecules described herein are expressed in mammalian cells using mammalian expression vectors. Examples of mammalian expression vectors include pCDM8 (Seed, B. Nature 329:840(1987)) and pMT2PC (Kaufman et al., EMBO J 6:187-195 (1987)).

The expression vectors listed herein are provided by way of example only of the well-known vectors available to those of ordinary skill in the art that would be useful to express the nucleic acid molecules. The person of ordinary skill in the art would be aware of other vectors suitable for maintenance propagation or expression of the nucleic acid molecules described herein. These are found for example in Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2 nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.

The invention also encompasses vectors in which the nucleic acid sequences described herein are cloned into the vector in reverse orientation, but operably linked to a regulatory sequence that permits transcription of antisense RNA. Thus, an antisense transcript can be produced to all, or to a portion, of the nucleic acid molecule sequences described herein, including both coding and non-coding regions. Expression of this antisense RNA is subject to each of the parameters described above in relation to expression of the sense RNA (regulatory sequences, constitutive or inducible expression, tissue-specific expression).

The invention also relates to recombinant host cells containing the vectors described herein. Host cells therefore include prokaryotic cells, lower eukaryotic cells such as yeast, other eukaryotic cells such as insect cells, and higher eukaryotic cells such as mammalian cells.

The recombinant host cells are prepared by introducing the vector constructs described herein into the cells by techniques readily available to the person of ordinary skill in the art. These include, but are not limited to, calcium phosphate transfection, DEAE-dextran-mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, lipofection, and other techniques such as those found in Sambrook, et al. ( Molecular Cloning: A Laboratory Manual. 2 nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989).

Host cells can contain more than one vector. Thus, different nucleotide sequences can be introduced on different vectors of the same cell. Similarly, the nucleic acid molecules can be introduced either alone or with other nucleic acid molecules that are not related to the nucleic acid molecules such as those providing trans-acting factors for expression vectors. When more than one vector is introduced into a cell, the vectors can be introduced independently, co-introduced or joined to the nucleic acid molecule vector.

In the case of bacteriophage and viral vectors, these can be introduced into cells as packaged or encapsulated virus by standard procedures for infection and transduction. Viral vectors can be replication-competent or replication-defective. In the case in which viral replication is defective, replication will occur in host cells providing functions that complement the defects.

Vectors generally include selectable markers that enable the selection of the subpopulation of cells that contain the recombinant vector constructs. The marker can be contained in the same vector that contains the nucleic acid molecules described herein or may be on a separate vector. Markers include tetracycline or ampicillin-resistance genes for prokaryotic host cells and dihydrofolate reductase or neomycin resistance for eukaryotic host cells. However, any marker that provides selection for a phenotypic trait will be effective.

While the mature proteins can be produced in bacteria, yeast, mammalian cells, and other cells under the control of the appropriate regulatory sequences, cell-free transcription and translation systems can also be used to produce these proteins using RNA derived from the DNA constructs described herein.

Where secretion of the peptide is desired, which is difficult to achieve with multi-transmembrane domain containing proteins such as phosphatases, appropriate secretion signals are incorporated into the vector. The signal sequence can be endogenous to the peptides or heterologous to these peptides.

Where the peptide is not secreted into the medium, which is typically the case with phosphatases, the protein can be isolated from the host cell by standard disruption procedures, including freeze thaw, sonication, mechanical disruption, use of lysing agents and the like. The peptide can then be recovered and purified by well-known purification methods including ammonium sulfate precipitation, acid extraction, anion or cationic exchange chromatography, phosphocellulose chromatography, hydrophobic-interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography, or high performance liquid chromatography.

It is also understood that depending upon the host cell in recombinant production of the peptides described herein, the peptides can have various glycosylation patterns, depending upon the cell, or maybe non-glycosylated as when produced in bacteria. In addition, the peptides may include an initial modified methionine in some cases as a result of a host-mediated process.

Uses of Vectors and Host Cells

The recombinant host cells expressing the peptides described herein have a variety of uses. First, the cells are useful for producing a phosphatase protein or peptide that can be further purified to produce desired amounts of phosphatase protein or fragments. Thus, host cells containing expression vectors are useful for peptide production.

Host cells are also useful for conducting cell-based assays involving the phosphatase protein or phosphatase protein fragments, such as those described above as well as other formats known in the art. Thus, a recombinant host cell expressing a native phosphatase protein is useful for assaying compounds that stimulate or inhibit phosphatase protein function.

Host cells are also useful for identifying phosphatase protein mutants in which these functions are affected. If the mutants naturally occur and give rise to a pathology, host cells containing the mutations are useful to assay compounds that have a desired effect on the mutant phosphatase protein (for example, stimulating or inhibiting function) which may not be indicated by their effect on the native phosphatase protein.

Genetically engineered host cells can be further used to produce non-human transgenic animals. A transgenic animal is preferably a mammal, for example a rodent, such as a rat or mouse, in which one or more of the cells of the animal include a transgene. A transgene is exogenous DNA which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal in one or more cell types or tissues of the transgenic animal. These animals are useful for studying the function of a phosphatase protein and identifying and evaluating modulators of phosphatase protein activity. Other examples of transgenic animals include non-human primates, sheep, dogs, cows, goats, chickens, and amphibians.

A transgenic animal can be produced by introducing nucleic acid into the male pronuclei of a fertilized oocyte, e.g., by microinjection, retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Any of the phosphatase protein nucleotide sequences can be introduced as a transgene into the genome of a non-human animal, such as a mouse.

Any of the regulatory or other sequences useful in expression vectors can form part of the transgenic sequence. This includes intronic sequences and polyadenylation signals, if not already included. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of the phosphatase protein to particular cells.

Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, both by Leder et al., U.S. Pat. No. 4,873,191 by Wagner et al. and in Hogan, B., Manipulating the Mouse Embryo , (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the transgene in its genome and/or expression of transgenic mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene can further be bred to other transgenic animals carrying other transgenes. A transgenic animal also includes animals in which the entire animal or tissues in the animal have been produced using the homologously recombinant host cells described herein.

In another embodiment, transgenic non-human animals can be produced which contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage P1. For a description of the cre/loxP recombinase system, see, e.g., Lakso et al. PNAS 89:6232-6236 (1992). Another example of a recombinase system is the FLP recombinase system of S. cerevisiae (O'Gorman et al. Science 251:1351-1355 (1991). If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein is required. Such animals can be provided through the construction of “double” transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected protein and the other containing a transgene encoding a recombinase.

Clones of the non-human transgenic animals described herein can also be produced according to the methods described in Wilmut, I. et al. Nature 385:810-813 (1997) and PCT International Publication Nos. WO 97/07668 and WO 97/07669. In brief, a cell, e.g., a somatic cell, from the transgenic animal can be isolated and induced to exit the growth cycle and enter G o phase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyst and then transferred to pseudopregnant female foster animal. The offspring born of this female foster animal will be a clone of the animal from which the cell, e.g., the somatic cell, is isolated.

Transgenic animals containing recombinant cells that express the peptides described herein are useful to conduct the assays described herein in an in vivo context. Accordingly, the various physiological factors that are present in vivo and that could effect substrate binding, kinase protein activation, and signal transduction, may not be evident from in vitro cell-free or cell-based assays. Accordingly, it is useful to provide non-human transgenic animals to assay in vivo phosphatase protein function, including substrate interaction, the effect of specific mutant phosphatase proteins on phosphatase protein function and substrate interaction, and the effect of chimeric phosphatase proteins. It is also possible to assess the effect of null mutations, that is mutations that substantially or completely eliminate one or more phosphatase protein functions.

All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention which are obvious to those skilled in the field of molecular biology or related fields are intended to be within the scope of the following claims.

#             SEQUENCE LISTING
<160> NUMBER OF SEQ ID NOS: 4
<210> SEQ ID NO 1
<211> LENGTH: 7108
<212> TYPE: DNA
<213> ORGANISM: Human
<400> SEQUENCE: 1
taattgtgta cttgccagaa ggatctgtct ttaaatcatt aatgcaggca ac
#atttctct     60
ctagagccat caatgtgatt ctactggctg aaaaatgtaa taaagatgga tt
#ttcttatc    120
atttttcttt tactttttat tgggacttca gagacacagg ttgatgtttc ca
#atgtcgtt    180
cctggtacta ggtacgatat aaccatctct tcaatttcta caacatacac ct
#cacctgtt    240
actagaatag tgacaccaaa tgtaacaaaa ccagggcctc cagtcttcct ag
#ccggggaa    300
agagtcggat ctgctgggat tcttctgtct tggaatacac cacctaatcc aa
#atggaagg    360
attatatctt acattgtcaa atataaggaa gtttgtccgt ggatgcaaac ag
#tatataca    420
caagtcagat caaagccaga cagtctggaa gttcttctta ctaatcttaa tc
#ctggaaca    480
acatatgaaa ttaaggttgc tgctgaaaac agtgctggca ttggagtgtt ta
#gtgatcca    540
tttctcttcc aaactgcaga aagtgctcca ggaaaagtgg tgaatctcac ag
#ttgaggcc    600
tacaacgctt cagcagttaa gctgatttgg tatttacctc ggcaaccaaa tg
#gcaaaatt    660
accagcttca agattagtgt caaacatgcc agaagtggga tagtagtgaa ag
#atgtctca    720
atcagagtag aggacatttt gactgggaaa ttgccagaat gcaatgagaa ta
#gtgaatct    780
tttttatgga gtacagccag cccttctcca acccttggta gagttacacc tc
#catcgcgt    840
accacacatt catcaagcac gttgacacag aatgagatca gctctgtgtg ga
#aagagcct    900
atcagttttg tagtgacaca cttgagacct tatacaacat atctttttga ag
#tttcagct    960
gctacaactg aagcaggtta tattgatagt acgattgtca gaacaccaga at
#cagtgcct   1020
gaaggaccac cacaaaactg cgtaacaggc aacatcacag gaaagtcctt tt
#caatttta   1080
tgggacccac caactatagt aacagggaaa tttagttata gagttgaatt at
#atggacca   1140
tcaggtcgca ttttggataa cagcacaaaa gacctcaagt ttgcattcac ta
#acctaaca   1200
ccatttacaa tgtatgatgt ctatattgcg gctgaaacca gtgcagggac tg
#ggcccaag   1260
tcaaatattt cagtattcac tccaccagat gttccagggg cagtgtttga tt
#tacaactt   1320
gcagaggtag aatccacgca agtaagaatt acttggaaga aaccacgaca ac
#caaatgga   1380
attattaacc aataccgagt gaaagtgcta gttccagaga caggaataat tt
#tggaaaat   1440
actttgctca ctggaaataa tgagtatata aatgacccca tggctccaga aa
#ttgtgaac   1500
atagtagagc caatggtagg attatatgag ggttcagcag agatgtcgtc tg
#accttcac   1560
tcacttgcta catttatata taacagccat ccagataaaa actttcctgc aa
#ggaataga   1620
gctgaagacc agacttcacc agttgtaact acaaggaatc agtatattac tg
#acattgca   1680
gctgaacagc tgtcttatgt tatcaggaga cttgtacctt tcactgagca ca
#tgattagt   1740
gtatctgctt tcaccatcat gggagaagga ccaccaacag ttctcagtgt ta
#ggacacgt   1800
cagcaagtgc caagctccat taaaattata aactataaaa atattagttc tt
#catctatt   1860
ttgttatatt gggatcctcc agaatatccc aatggaaaaa taactcacta ta
#cgatttat   1920
gcaatggaat tggatacaaa cagagcattc cagataacta ccatagataa ca
#gctttctc   1980
ataacagggt taaagaaata cacaaaatac aaaatgagag tggcagcctc aa
#cccacgat   2040
ggagaaagtt ctttgtctga agaaaatgac atctttgtga gaacttcaga ag
#atgaaccg   2100
gaatcatcac ctcaagatgt cgaagtaatt gatgttaccg cagatgaaat aa
#ggttgaag   2160
tggtcaccac ccgaaaagcc caatgggatc attattgctt atgaagtgct at
#ataaaaat   2220
atagatactt tatatatgaa gaacacatca acaacagaca taatattaag ga
#acttaaga   2280
cctcacaccc tctataacat ttctgtaagg tcttacacca gatttggtca tg
#gcaatcag   2340
gtatcttctt tactctctgt aaggacttcg gagactgtgc ctgatagtgc ac
#cagaaaat   2400
atcacttaca aaaatatttc ttctggagag attgagctat cattccttcc cc
#caagtagt   2460
cccaatggaa tcataaaaaa atatacaatt tatctcaaga gaagtaatgg aa
#atgaggaa   2520
agaactataa atacaacctc tttaacccaa aacattaaag tactgaagaa at
#atacccaa   2580
tatatcattg aggtgtctgc tagtacactg aaaggtgaag gagttcggag tg
#ctcccata   2640
agtatactga cggaggaaga tgctcctgat tctccccctc aagacttctc tg
#taaaacag   2700
ttgtctggtg tcacggtgaa gttgtcatgg caaccacccc tggagccaaa tg
#gaattatc   2760
ctttattaca cagtttatgt ctggaataga tcatcattaa aaactattaa tg
#tcactgaa   2820
acatcattgg agttatcaga tttggattat aatgttgaat acagtgctta tg
#taacagct   2880
agcaccagat ttggtgatgg gaaaacagga agcaatatca ttagctttca aa
#caccagag   2940
ggagcaccaa gcgatcctcc caaagatgtt tattatgcaa acctcagttc tt
#catcaata   3000
attcttttct ggacacctcc ttcaaaacct aatgggatta tacaatatta ct
#ctgtttat   3060
tacagaaata cttcaggtac ttttatgcag aattttacac tccatgaact aa
#ccaatgac   3120
tttgacaata tgactgtatc cacaattata gataaactga caatattcag ct
#actataca   3180
ttttggttaa cagcaagtac ttcagttgga aatgggaata aaagcagtga ca
#tcattgaa   3240
gtatacacag atcaagacat acctgaaggg tttgttggaa acctgactta cg
#aatccatt   3300
tcgtcaactg caataaatgt aagctgggtc ccaccggctc aaccaaacgg tc
#tagtcttc   3360
tactatgttt cactgatctt acagcagact cctcgccatg tgagaccacc tc
#ttgttaca   3420
tatgagagaa gcatatattt tgataatctg gaaaaataca ctgattatat at
#taaaaatt   3480
actccatcaa cagaaaaggg attctctgat acctatactg cccagctata ca
#tcaagact   3540
gaagaagatg tcccagaaac ttcaccaata atcaacactt ttaaaaacct tt
#cctctacc   3600
tcagttctct tatcatggga tcccccagta aagccaaatg gtgcaataat aa
#gttatgat   3660
ttaactttac aaggaccaaa tgaaaattat tctttcatta cttctgataa tt
#acataata   3720
ttggaagagc tttcaccatt tacattatat agcttttttg ctgccgcaag aa
#ctagaaaa   3780
ggacttggtc cttccagtat tcttttcttt tacacagatg agtcagtgcc gt
#tagcacct   3840
ccacaaaatt tgactttaat caactgtact tcagactttg tatggctgaa at
#ggagccca   3900
agtcctcttc caggtggtat tgttaaagta tatagtttta aaattcatga ac
#atgaaact   3960
gacactatat attataagaa tatatcagga tttaaaactg aagccaaact tg
#ttggactg   4020
gaaccagtca gcacctactc tatccgtgta tctgcgttca ccaaagttgg aa
#atggcaat   4080
caatttagta atgtagtaaa attcacaacc caagaatcag ttccagatgt cg
#tgcagaat   4140
atgcagtgca tggcaactag ctggcagtca gttttagtga aatgggatcc ac
#ccaaaaag   4200
gcaaatggaa taataacgca gtatatggta acagttgaaa ggaattctac aa
#aagtttct   4260
ccccaagatc acatgtacac tttcataaag cttcttgcca atacctcata tg
#tctttaaa   4320
gtaagagctt caacctcagc tggtgaaggt gatgaaagca catgccatgt ca
#gcacacta   4380
cctgaaacag ttcccagtgt tcccacaaat attgcttttt ctgatgttca gt
#caactagt   4440
gcaacattga catggataag acctgacact atccttggct actttcaaaa tt
#acaaaatt   4500
accactcaac ttcgtgctca aaaatgcaaa gaatgggaat ccgaagaatg tg
#ttgaatat   4560
caaaaaattc aatacctcta tgaagctcac ttaactgaag agacagtata tg
#gattaaag   4620
aaatttagat ggtatagatt ccaagtggct gccagcacca atgctggcta tg
#gcaatgct   4680
tcaaactgga tttctacaaa aactctgcct ggccctccag atggtcctcc tg
#aaaatgtt   4740
catgtagtag caacatcacc ttttagcatc agcataagct ggagtgaacc tg
#ctgtcatt   4800
actggaccaa catgttatct gattgatgtc aaatcggtag ataatgatga at
#ttaatata   4860
tccttcatca agtcaaatga agaaaataaa accatagaaa ttaaagattt ag
#aaatattc   4920
acaaggtatt ctgtagtgat cactgcattt actgggaaca ttagtgctgc at
#atgtagaa   4980
gggaagtcaa gtgctgaaat gattgttact actttagaat cagccccaaa gg
#acccacct   5040
aacaacatga catttcagaa gataccagat gaagttacaa aatttcaatt aa
#cgttcctt   5100
cctccttctc aacctaatgg aaatatccaa gtatatcaag ctctggttta cc
#gagaagat   5160
gatcctactg ctgtccagat tcacaacctc agtattatac agaaaaccaa ca
#cattcgtc   5220
attgcaatgc tagaaggact aaaaggtgga catacataca atatcagtgt tt
#acgcagtc   5280
aatagtgctg gtgcaggtcc aaaggttccg atgagaataa ccatggatat ca
#aagctcca   5340
gcacgaccaa aaaccaaacc aacccctatt tatgatgcca caggaaaact gc
#ttgtgact   5400
tcaacaacaa ttacaatcag aatgccaata tgttactaca gtgatgatca tg
#gaccaata   5460
aaaaatgtac aagtgcttgc gacagaaaca ggagctcagc atgatggaaa tg
#taacaaag   5520
tggtatgatg catattttaa taaagcaagg ccatatttta caaatgaagg ct
#ttcctaac   5580
cctccatgta cagaaggaaa gacaaagttt agtggcaatg aagaaatcta ca
#tcataggt   5640
gctgataatg catgcatgat tcctggcaat gaagacaaaa tttgcaatgg ac
#cactgaaa   5700
ccaaaaaagc aatacttatt taaatttaga gctacaaata ttatgggaca at
#ttactgac   5760
tctgattatt ctgaccctgt taagacttta ggggaaggac tttcagaaag aa
#ccgtagag   5820
atcattcttt ccgtcacttt gtgtatcctt tcaataattc tccttggaac ag
#ctattttt   5880
gcatttgcaa gaattcgaca gaagcagaaa gaaggtggca catactctcc tc
#aggatgca   5940
gaaattattg acactaaatt gaagctggat cagctcatca cagtggcaga cc
#tggaactg   6000
aaggacgaga gattaacgcg gccaataagc aagaaatcct tcctgcaaca tg
#ttgaagag   6060
ctttgcacaa acaacaacct aaagtttcaa gaagaatttt cggaattacc aa
#aatttctt   6120
caggatcttt cttcaactga tgctgatctg ccttggaata gagcaaaaaa cc
#gtttccca   6180
aacataaaac catataataa taataacaga gtaaagctga tagctgacgc ta
#gtgttcca   6240
ggttcggatt atattaatgc cagctatatt tctggttatt tatgtccaaa tg
#aatttatt   6300
gctactcaag gtccactacc aggaacagtt ggagattttt ggagaatggt gt
#gggaaacc   6360
agggcaaaaa cattagtaat gctaacacag tgttttgaaa aaggacggat ca
#gatgccat   6420
cagtattggc cagaggacaa caagccagtt actgtctttg gagatatagt ga
#ttacaaag   6480
ctaatggagg atgttcaaat agattggact atcagggatc tgaaaattga aa
#ggcatggg   6540
gattgcatga ctgttcgaca gtgtaacttt actgcctggc cagagcatgg gg
#ttcctgag   6600
aacagcgccc ctctaattca ctttgtgaag ttggttcgag caagcagggc ac
#atgacacc   6660
acacctatga ttgttcactg cagtgctgga gttggaagaa ctggagtttt ta
#ttgctctg   6720
gaccatttaa cacaacatat aaatgaccat gattttgtgg atatatatgg ac
#tagtagct   6780
gaactgagaa gtgaaagaat gtgcatggtg cagaatctgg cacagtatat ct
#ttttacac   6840
cagtgcattc tggatctctt atcaaataag ggaagtaatc agcccatctg tt
#ttgttaac   6900
tattcagcac ttcagaagat ggactctttg gacgccatgg aaggtgatgt tg
#agcttgaa   6960
tgggaagaaa ccactatgta aatattcaga ccaaaggata caattggaag ag
#atttttaa   7020
atcccagggg ccaaagttac cccctcattc ttccgaattg aaatgtgcaa cc
#ttaaagaa   7080
atatctatgc ttctctcact gtgccttt
#
#           7108
<210> SEQ ID NO 2
<211> LENGTH: 2291
<212> TYPE: PRT
<213> ORGANISM: Human
<400> SEQUENCE: 2
Met Asp Phe Leu Ile Ile Phe Leu Leu Leu Ph
#e Ile Gly Thr Ser Glu
1               5
#                10
#                15
Thr Gln Val Asp Val Ser Asn Val Val Pro Gl
#y Thr Arg Tyr Asp Ile
20
#            25
#            30
Thr Ile Ser Ser Ile Ser Thr Thr Tyr Thr Se
#r Pro Val Thr Arg Ile
35
#        40
#        45
Val Thr Pro Asn Val Thr Lys Pro Gly Pro Pr
#o Val Phe Leu Ala Gly
50
#    55
#    60
Glu Arg Val Gly Ser Ala Gly Ile Leu Leu Se
#r Trp Asn Thr Pro Pro
65
#70
#75
#80
Asn Pro Asn Gly Arg Ile Ile Ser Tyr Ile Va
#l Lys Tyr Lys Glu Val
85
#                90
#                95
Cys Pro Trp Met Gln Thr Val Tyr Thr Gln Va
#l Arg Ser Lys Pro Asp
100
#           105
#           110
Ser Leu Glu Val Leu Leu Thr Asn Leu Asn Pr
#o Gly Thr Thr Tyr Glu
115
#       120
#       125
Ile Lys Val Ala Ala Glu Asn Ser Ala Gly Il
#e Gly Val Phe Ser Asp
130
#   135
#   140
Pro Phe Leu Phe Gln Thr Ala Glu Ser Ala Pr
#o Gly Lys Val Val Asn
145                 1
#50                 1
#55                 1
#60
Leu Thr Val Glu Ala Tyr Asn Ala Ser Ala Va
#l Lys Leu Ile Trp Tyr
165
#               170
#               175
Leu Pro Arg Gln Pro Asn Gly Lys Ile Thr Se
#r Phe Lys Ile Ser Val
180
#           185
#           190
Lys His Ala Arg Ser Gly Ile Val Val Lys As
#p Val Ser Ile Arg Val
195
#       200
#       205
Glu Asp Ile Leu Thr Gly Lys Leu Pro Glu Cy
#s Asn Glu Asn Ser Glu
210
#   215
#   220
Ser Phe Leu Trp Ser Thr Ala Ser Pro Ser Pr
#o Thr Leu Gly Arg Val
225                 2
#30                 2
#35                 2
#40
Thr Pro Pro Ser Arg Thr Thr His Ser Ser Se
#r Thr Leu Thr Gln Asn
245
#               250
#               255
Glu Ile Ser Ser Val Trp Lys Glu Pro Ile Se
#r Phe Val Val Thr His
260
#           265
#           270
Leu Arg Pro Tyr Thr Thr Tyr Leu Phe Glu Va
#l Ser Ala Ala Thr Thr
275
#       280
#       285
Glu Ala Gly Tyr Ile Asp Ser Thr Ile Val Ar
#g Thr Pro Glu Ser Val
290
#   295
#   300
Pro Glu Gly Pro Pro Gln Asn Cys Val Thr Gl
#y Asn Ile Thr Gly Lys
305                 3
#10                 3
#15                 3
#20
Ser Phe Ser Ile Leu Trp Asp Pro Pro Thr Il
#e Val Thr Gly Lys Phe
325
#               330
#               335
Ser Tyr Arg Val Glu Leu Tyr Gly Pro Ser Gl
#y Arg Ile Leu Asp Asn
340
#           345
#           350
Ser Thr Lys Asp Leu Lys Phe Ala Phe Thr As
#n Leu Thr Pro Phe Thr
355
#       360
#       365
Met Tyr Asp Val Tyr Ile Ala Ala Glu Thr Se
#r Ala Gly Thr Gly Pro
370
#   375
#   380
Lys Ser Asn Ile Ser Val Phe Thr Pro Pro As
#p Val Pro Gly Ala Val
385                 3
#90                 3
#95                 4
#00
Phe Asp Leu Gln Leu Ala Glu Val Glu Ser Th
#r Gln Val Arg Ile Thr
405
#               410
#               415
Trp Lys Lys Pro Arg Gln Pro Asn Gly Ile Il
#e Asn Gln Tyr Arg Val
420
#           425
#           430
Lys Val Leu Val Pro Glu Thr Gly Ile Ile Le
#u Glu Asn Thr Leu Leu
435
#       440
#       445
Thr Gly Asn Asn Glu Tyr Ile Asn Asp Pro Me
#t Ala Pro Glu Ile Val
450
#   455
#   460
Asn Ile Val Glu Pro Met Val Gly Leu Tyr Gl
#u Gly Ser Ala Glu Met
465                 4
#70                 4
#75                 4
#80
Ser Ser Asp Leu His Ser Leu Ala Thr Phe Il
#e Tyr Asn Ser His Pro
485
#               490
#               495
Asp Lys Asn Phe Pro Ala Arg Asn Arg Ala Gl
#u Asp Gln Thr Ser Pro
500
#           505
#           510
Val Val Thr Thr Arg Asn Gln Tyr Ile Thr As
#p Ile Ala Ala Glu Gln
515
#       520
#       525
Leu Ser Tyr Val Ile Arg Arg Leu Val Pro Ph
#e Thr Glu His Met Ile
530
#   535
#   540
Ser Val Ser Ala Phe Thr Ile Met Gly Glu Gl
#y Pro Pro Thr Val Leu
545                 5
#50                 5
#55                 5
#60
Ser Val Arg Thr Arg Gln Gln Val Pro Ser Se
#r Ile Lys Ile Ile Asn
565
#               570
#               575
Tyr Lys Asn Ile Ser Ser Ser Ser Ile Leu Le
#u Tyr Trp Asp Pro Pro
580
#           585
#           590
Glu Tyr Pro Asn Gly Lys Ile Thr His Tyr Th
#r Ile Tyr Ala Met Glu
595
#       600
#       605
Leu Asp Thr Asn Arg Ala Phe Gln Ile Thr Th
#r Ile Asp Asn Ser Phe
610
#   615
#   620
Leu Ile Thr Gly Leu Lys Lys Tyr Thr Lys Ty
#r Lys Met Arg Val Ala
625                 6
#30                 6
#35                 6
#40
Ala Ser Thr His Asp Gly Glu Ser Ser Leu Se
#r Glu Glu Asn Asp Ile
645
#               650
#               655
Phe Val Arg Thr Ser Glu Asp Glu Pro Glu Se
#r Ser Pro Gln Asp Val
660
#           665
#           670
Glu Val Ile Asp Val Thr Ala Asp Glu Ile Ar
#g Leu Lys Trp Ser Pro
675
#       680
#       685
Pro Glu Lys Pro Asn Gly Ile Ile Ile Ala Ty
#r Glu Val Leu Tyr Lys
690
#   695
#   700
Asn Ile Asp Thr Leu Tyr Met Lys Asn Thr Se
#r Thr Thr Asp Ile Ile
705                 7
#10                 7
#15                 7
#20
Leu Arg Asn Leu Arg Pro His Thr Leu Tyr As
#n Ile Ser Val Arg Ser
725
#               730
#               735
Tyr Thr Arg Phe Gly His Gly Asn Gln Val Se
#r Ser Leu Leu Ser Val
740
#           745
#           750
Arg Thr Ser Glu Thr Val Pro Asp Ser Ala Pr
#o Glu Asn Ile Thr Tyr
755
#       760
#       765
Lys Asn Ile Ser Ser Gly Glu Ile Glu Leu Se
#r Phe Leu Pro Pro Ser
770
#   775
#   780
Ser Pro Asn Gly Ile Ile Lys Lys Tyr Thr Il
#e Tyr Leu Lys Arg Ser
785                 7
#90                 7
#95                 8
#00
Asn Gly Asn Glu Glu Arg Thr Ile Asn Thr Th
#r Ser Leu Thr Gln Asn
805
#               810
#               815
Ile Lys Val Leu Lys Lys Tyr Thr Gln Tyr Il
#e Ile Glu Val Ser Ala
820
#           825
#           830
Ser Thr Leu Lys Gly Glu Gly Val Arg Ser Al
#a Pro Ile Ser Ile Leu
835
#       840
#       845
Thr Glu Glu Asp Ala Pro Asp Ser Pro Pro Gl
#n Asp Phe Ser Val Lys
850
#   855
#   860
Gln Leu Ser Gly Val Thr Val Lys Leu Ser Tr
#p Gln Pro Pro Leu Glu
865                 8
#70                 8
#75                 8
#80
Pro Asn Gly Ile Ile Leu Tyr Tyr Thr Val Ty
#r Val Trp Asn Arg Ser
885
#               890
#               895
Ser Leu Lys Thr Ile Asn Val Thr Glu Thr Se
#r Leu Glu Leu Ser Asp
900
#           905
#           910
Leu Asp Tyr Asn Val Glu Tyr Ser Ala Tyr Va
#l Thr Ala Ser Thr Arg
915
#       920
#       925
Phe Gly Asp Gly Lys Thr Gly Ser Asn Ile Il
#e Ser Phe Gln Thr Pro
930
#   935
#   940
Glu Gly Ala Pro Ser Asp Pro Pro Lys Asp Va
#l Tyr Tyr Ala Asn Leu
945                 9
#50                 9
#55                 9
#60
Ser Ser Ser Ser Ile Ile Leu Phe Trp Thr Pr
#o Pro Ser Lys Pro Asn
965
#               970
#               975
Gly Ile Ile Gln Tyr Tyr Ser Val Tyr Tyr Ar
#g Asn Thr Ser Gly Thr
980
#           985
#           990
Phe Met Gln Asn Phe Thr Leu His Glu Leu Th
#r Asn Asp Phe Asp Asn
995
#       1000
#      1005
Met Thr Val Ser Thr Ile Ile Asp Lys Leu Th
#r Ile Phe Ser Tyr Tyr
1010
#   1015
#  1020
Thr Phe Trp Leu Thr Ala Ser Thr Ser Val Gl
#y Asn Gly Asn Lys Ser
1025                1030
#                1035
#               1040
Ser Asp Ile Ile Glu Val Tyr Thr Asp Gln As
#p Ile Pro Glu Gly Phe
1045
#               1050
#              1055
Val Gly Asn Leu Thr Tyr Glu Ser Ile Ser Se
#r Thr Ala Ile Asn Val
1060
#           1065
#          1070
Ser Trp Val Pro Pro Ala Gln Pro Asn Gly Le
#u Val Phe Tyr Tyr Val
1075
#       1080
#      1085
Ser Leu Ile Leu Gln Gln Thr Pro Arg His Va
#l Arg Pro Pro Leu Val
1090
#   1095
#  1100
Thr Tyr Glu Arg Ser Ile Tyr Phe Asp Asn Le
#u Glu Lys Tyr Thr Asp
1105                1110
#                1115
#               1120
Tyr Ile Leu Lys Ile Thr Pro Ser Thr Glu Ly
#s Gly Phe Ser Asp Thr
1125
#               1130
#              1135
Tyr Thr Ala Gln Leu Tyr Ile Lys Thr Glu Gl
#u Asp Val Pro Glu Thr
1140
#           1145
#          1150
Ser Pro Ile Ile Asn Thr Phe Lys Asn Leu Se
#r Ser Thr Ser Val Leu
1155
#       1160
#      1165
Leu Ser Trp Asp Pro Pro Val Lys Pro Asn Gl
#y Ala Ile Ile Ser Tyr
1170
#   1175
#  1180
Asp Leu Thr Leu Gln Gly Pro Asn Glu Asn Ty
#r Ser Phe Ile Thr Ser
1185                1190
#                1195
#               1200
Asp Asn Tyr Ile Ile Leu Glu Glu Leu Ser Pr
#o Phe Thr Leu Tyr Ser
1205
#               1210
#              1215
Phe Phe Ala Ala Ala Arg Thr Arg Lys Gly Le
#u Gly Pro Ser Ser Ile
1220
#           1225
#          1230
Leu Phe Phe Tyr Thr Asp Glu Ser Val Pro Le
#u Ala Pro Pro Gln Asn
1235
#       1240
#      1245
Leu Thr Leu Ile Asn Cys Thr Ser Asp Phe Va
#l Trp Leu Lys Trp Ser
1250
#   1255
#  1260
Pro Ser Pro Leu Pro Gly Gly Ile Val Lys Va
#l Tyr Ser Phe Lys Ile
1265                1270
#                1275
#               1280
His Glu His Glu Thr Asp Thr Ile Tyr Tyr Ly
#s Asn Ile Ser Gly Phe
1285
#               1290
#              1295
Lys Thr Glu Ala Lys Leu Val Gly Leu Glu Pr
#o Val Ser Thr Tyr Ser
1300
#           1305
#          1310
Ile Arg Val Ser Ala Phe Thr Lys Val Gly As
#n Gly Asn Gln Phe Ser
1315
#       1320
#      1325
Asn Val Val Lys Phe Thr Thr Gln Glu Ser Va
#l Pro Asp Val Val Gln
1330
#   1335
#  1340
Asn Met Gln Cys Met Ala Thr Ser Trp Gln Se
#r Val Leu Val Lys Trp
1345                1350
#                1355
#               1360
Asp Pro Pro Lys Lys Ala Asn Gly Ile Ile Th
#r Gln Tyr Met Val Thr
1365
#               1370
#              1375
Val Glu Arg Asn Ser Thr Lys Val Ser Pro Gl
#n Asp His Met Tyr Thr
1380
#           1385
#          1390
Phe Ile Lys Leu Leu Ala Asn Thr Ser Tyr Va
#l Phe Lys Val Arg Ala
1395
#       1400
#      1405
Ser Thr Ser Ala Gly Glu Gly Asp Glu Ser Th
#r Cys His Val Ser Thr
1410
#   1415
#  1420
Leu Pro Glu Thr Val Pro Ser Val Pro Thr As
#n Ile Ala Phe Ser Asp
1425                1430
#                1435
#               1440
Val Gln Ser Thr Ser Ala Thr Leu Thr Trp Il
#e Arg Pro Asp Thr Ile
1445
#               1450
#              1455
Leu Gly Tyr Phe Gln Asn Tyr Lys Ile Thr Th
#r Gln Leu Arg Ala Gln
1460
#           1465
#          1470
Lys Cys Lys Glu Trp Glu Ser Glu Glu Cys Va
#l Glu Tyr Gln Lys Ile
1475
#       1480
#      1485
Gln Tyr Leu Tyr Glu Ala His Leu Thr Glu Gl
#u Thr Val Tyr Gly Leu
1490
#   1495
#  1500
Lys Lys Phe Arg Trp Tyr Arg Phe Gln Val Al
#a Ala Ser Thr Asn Ala
1505                1510
#                1515
#               1520
Gly Tyr Gly Asn Ala Ser Asn Trp Ile Ser Th
#r Lys Thr Leu Pro Gly
1525
#               1530
#              1535
Pro Pro Asp Gly Pro Pro Glu Asn Val His Va
#l Val Ala Thr Ser Pro
1540
#           1545
#          1550
Phe Ser Ile Ser Ile Ser Trp Ser Glu Pro Al
#a Val Ile Thr Gly Pro
1555
#       1560
#      1565
Thr Cys Tyr Leu Ile Asp Val Lys Ser Val As
#p Asn Asp Glu Phe Asn
1570
#   1575
#  1580
Ile Ser Phe Ile Lys Ser Asn Glu Glu Asn Ly
#s Thr Ile Glu Ile Lys
1585                1590
#                1595
#               1600
Asp Leu Glu Ile Phe Thr Arg Tyr Ser Val Va
#l Ile Thr Ala Phe Thr
1605
#               1610
#              1615
Gly Asn Ile Ser Ala Ala Tyr Val Glu Gly Ly
#s Ser Ser Ala Glu Met
1620
#           1625
#          1630
Ile Val Thr Thr Leu Glu Ser Ala Pro Lys As
#p Pro Pro Asn Asn Met
1635
#       1640
#      1645
Thr Phe Gln Lys Ile Pro Asp Glu Val Thr Ly
#s Phe Gln Leu Thr Phe
1650
#   1655
#  1660
Leu Pro Pro Ser Gln Pro Asn Gly Asn Ile Gl
#n Val Tyr Gln Ala Leu
1665                1670
#                1675
#               1680
Val Tyr Arg Glu Asp Asp Pro Thr Ala Val Gl
#n Ile His Asn Leu Ser
1685
#               1690
#              1695
Ile Ile Gln Lys Thr Asn Thr Phe Val Ile Al
#a Met Leu Glu Gly Leu
1700
#           1705
#          1710
Lys Gly Gly His Thr Tyr Asn Ile Ser Val Ty
#r Ala Val Asn Ser Ala
1715
#       1720
#      1725
Gly Ala Gly Pro Lys Val Pro Met Arg Ile Th
#r Met Asp Ile Lys Ala
1730
#   1735
#  1740
Pro Ala Arg Pro Lys Thr Lys Pro Thr Pro Il
#e Tyr Asp Ala Thr Gly
1745                1750
#                1755
#               1760
Lys Leu Leu Val Thr Ser Thr Thr Ile Thr Il
#e Arg Met Pro Ile Cys
1765
#               1770
#              1775
Tyr Tyr Ser Asp Asp His Gly Pro Ile Lys As
#n Val Gln Val Leu Ala
1780
#           1785
#          1790
Thr Glu Thr Gly Ala Gln His Asp Gly Asn Va
#l Thr Lys Trp Tyr Asp
1795
#       1800
#      1805
Ala Tyr Phe Asn Lys Ala Arg Pro Tyr Phe Th
#r Asn Glu Gly Phe Pro
1810
#   1815
#  1820
Asn Pro Pro Cys Thr Glu Gly Lys Thr Lys Ph
#e Ser Gly Asn Glu Glu
1825                1830
#                1835
#               1840
Ile Tyr Ile Ile Gly Ala Asp Asn Ala Cys Me
#t Ile Pro Gly Asn Glu
1845
#               1850
#              1855
Asp Lys Ile Cys Asn Gly Pro Leu Lys Pro Ly
#s Lys Gln Tyr Leu Phe
1860
#           1865
#          1870
Lys Phe Arg Ala Thr Asn Ile Met Gly Gln Ph
#e Thr Asp Ser Asp Tyr
1875
#       1880
#      1885
Ser Asp Pro Val Lys Thr Leu Gly Glu Gly Le
#u Ser Glu Arg Thr Val
1890
#   1895
#  1900
Glu Ile Ile Leu Ser Val Thr Leu Cys Ile Le
#u Ser Ile Ile Leu Leu
1905                1910
#                1915
#               1920
Gly Thr Ala Ile Phe Ala Phe Ala Arg Ile Ar
#g Gln Lys Gln Lys Glu
1925
#               1930
#              1935
Gly Gly Thr Tyr Ser Pro Gln Asp Ala Glu Il
#e Ile Asp Thr Lys Leu
1940
#           1945
#          1950
Lys Leu Asp Gln Leu Ile Thr Val Ala Asp Le
#u Glu Leu Lys Asp Glu
1955
#       1960
#      1965
Arg Leu Thr Arg Pro Ile Ser Lys Lys Ser Ph
#e Leu Gln His Val Glu
1970
#   1975
#  1980
Glu Leu Cys Thr Asn Asn Asn Leu Lys Phe Gl
#n Glu Glu Phe Ser Glu
1985                1990
#                1995
#               2000
Leu Pro Lys Phe Leu Gln Asp Leu Ser Ser Th
#r Asp Ala Asp Leu Pro
2005
#               2010
#              2015
Trp Asn Arg Ala Lys Asn Arg Phe Pro Asn Il
#e Lys Pro Tyr Asn Asn
2020
#           2025
#          2030
Asn Asn Arg Val Lys Leu Ile Ala Asp Ala Se
#r Val Pro Gly Ser Asp
2035
#       2040
#      2045
Tyr Ile Asn Ala Ser Tyr Ile Ser Gly Tyr Le
#u Cys Pro Asn Glu Phe
2050
#   2055
#  2060
Ile Ala Thr Gln Gly Pro Leu Pro Gly Thr Va
#l Gly Asp Phe Trp Arg
2065                2070
#                2075
#               2080
Met Val Trp Glu Thr Arg Ala Lys Thr Leu Va
#l Met Leu Thr Gln Cys
2085
#               2090
#              2095
Phe Glu Lys Gly Arg Ile Arg Cys His Gln Ty
#r Trp Pro Glu Asp Asn
2100
#           2105
#          2110
Lys Pro Val Thr Val Phe Gly Asp Ile Val Il
#e Thr Lys Leu Met Glu
2115
#       2120
#      2125
Asp Val Gln Ile Asp Trp Thr Ile Arg Asp Le
#u Lys Ile Glu Arg His
2130
#   2135
#  2140
Gly Asp Cys Met Thr Val Arg Gln Cys Asn Ph
#e Thr Ala Trp Pro Glu
2145                2150
#                2155
#               2160
His Gly Val Pro Glu Asn Ser Ala Pro Leu Il
#e His Phe Val Lys Leu
2165
#               2170
#              2175
Val Arg Ala Ser Arg Ala His Asp Thr Thr Pr
#o Met Ile Val His Cys
2180
#           2185
#          2190
Ser Ala Gly Val Gly Arg Thr Gly Val Phe Il
#e Ala Leu Asp His Leu
2195
#       2200
#      2205
Thr Gln His Ile Asn Asp His Asp Phe Val As
#p Ile Tyr Gly Leu Val
2210
#   2215
#  2220
Ala Glu Leu Arg Ser Glu Arg Met Cys Met Va
#l Gln Asn Leu Ala Gln
2225                2230
#                2235
#               2240
Tyr Ile Phe Leu His Gln Cys Ile Leu Asp Le
#u Leu Ser Asn Lys Gly
2245
#               2250
#              2255
Ser Asn Gln Pro Ile Cys Phe Val Asn Tyr Se
#r Ala Leu Gln Lys Met
2260
#           2265
#          2270
Asp Ser Leu Asp Ala Met Glu Gly Asp Val Gl
#u Leu Glu Trp Glu Glu
2275
#       2280
#      2285
Thr Thr Met
2290
<210> SEQ ID NO 3
<211> LENGTH: 254366
<212> TYPE: DNA
<213> ORGANISM: Human
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)...(254366)
<223> OTHER INFORMATION: n = A,T,C or G
<400> SEQUENCE: 3
cattatctat ggaacataat ctgaggcttt ttttttacag ttggtagata ct
#tatgtaca     60
agattttgct gtgaaaatca gggcaagaag gtagtgatgc aaggtagcag at
#aacattga    120
aatacatttt tgaaaataat ttttaaaatt gatgtaatgc aattagatta ct
#tgagctaa    180
tagcatagct ttattttatt ttatttattt tattttattt atttttttga ga
#cacagtct    240
tgctctgttg cccaggctgg agtgcagttg ccgatattgg ctcacttcag cc
#tccgcctc    300
ctgagctcaa gcaattctcg tgcctcagcc tcctgaaagc tgggaccaca gg
#tctgccca    360
ccacgcaggg ctaatttttt tatttttagt ggagacaggg ttttgccatg tt
#gcccaggc    420
tgaccttaaa ctcctggtct caagtgatcc aaccgccttg gtctcccgaa gt
#gccggcat    480
tacaggtgtg agccaccaca ctcgtcttaa ttgcatagtt ttagagatcc at
#gttggatt    540
agctcttctg tagtgtcctg atgacctgtg accaatgata agagtatgga at
#taggtagt    600
ttctatgaaa aggcatcttt tctggcgact aatagccaca gtatcaagag tt
#ttaaaagc    660
ccctctcctc tggtctcaat ggagtcaaag aaaactctcc cgactgctcc tg
#aaaaagga    720
tgtcaaatga aactgtttca aattgctgaa tagcctggct aatcctgcct gt
#ctccaatc    780
acatactccg aatccatatt tttctcactg tggtaagctt tccaactatt tt
#tcagaaaa    840
caaaacttat atttggaata acttggtgct tctgtggcag taaaaccatg ac
#tgaaatgt    900
atctctgtgg aaacccttac ttcatttaaa atttattatt cctcctaatg at
#tcaaggct    960
tcaaatattt caatggtaaa gaaagagctt tttctattca gagggaatat tc
#atttactt   1020
cttcagtgct ttgtgtgtct aaagtagaaa aatatgagat tacatgagac at
#atactttt   1080
tcagtgttac tgatcatatt cccttatcta aattctttaa taactaactt ta
#ttattcct   1140
aaaatataaa taaaaaataa tgcacatttt tcagcatcac tatacacatg tt
#catttttt   1200
ggttttagat attaatctat acccagttca aactgtggaa actgaactaa ca
#tgactgaa   1260
ataaaatagt gttatatttt gttctttaga ctcttttttc ccttcctgag at
#tttgatat   1320
gtatttggag agttttgagt caatatttat ttgatttgtt ttcttttctg ga
#gtgatatt   1380
gtaaatactt taaagatttt gattgagtga gaggtgtgag ctatattttc tt
#ctttcctg   1440
tatgatatac atacattgtt tccaatctaa tttctattaa ataactatag ga
#gagcccac   1500
agccttgtta ttttacatat cactatttag atatttgtta tttatttatt tg
#tgttggcc   1560
tgaagtaaat gttacttttg tacgatattt gaaggataga tttattttat aa
#attaatag   1620
tttaaataag attttgccag catttgaaat gaacaaatgt ttggacaatg aa
#aacatcag   1680
tatgaaaggg aatactgtaa ttactttagt acatagtatt ccttaatatc ca
#ttaaaatt   1740
ggtccaagca aactctaatt atgaacatca tattaacatt tgatctaatt ac
#tgaatata   1800
attaaaagca aaataagtta atttactaaa gaattctgaa atttactatt tt
#cagtattt   1860
caggataacc aacatctttt ttctattaat ctagaataaa tttccatata tt
#aatgttgt   1920
ttacttttaa tgttagtgtg ctcaaaaagt attgttaact tttaaaattc aa
#ttctacag   1980
ataatattct ttttatctca ggaatagatc atcattaaaa actattaatg tc
#actgaaac   2040
atcattggag ttatcagatt tggattataa tgttgaatac agtgcttatg ta
#acagctag   2100
caccagattt ggtgatggga aaacaagaag caatatcatt agctttcaaa ca
#ccagaggg   2160
aggtgagtta aggatgtatg ccaattaaaa gaatgttctt tttctttaaa aa
#aaaaatcc   2220
tgcccagaaa aatattcaaa tatcaaaatg tatgatgaag cctaatattc at
#catcagtt   2280
tgatgaaaaa ttgcattttg atcacttttt agctgtgtga tgttgggaaa at
#taatctct   2340
gtgtgcctca atttcccatt ggtaatgtgg aaacagtatc attctacttc ac
#agggttct   2400
tatgaagatt acataagttt atatttttaa aagcacttag tacagaagtt ac
#ttggacaa   2460
atagaatttt atgtgtttat taaacgaaac aacataaaat gcatgaatca tt
#tgtctatg   2520
acttttatta ttcaatataa aaattctaag ttatattaga atttcaaatt at
#gtattttg   2580
tattggaaac ctgttataat attgttctca tatccagagc agtggacagg tt
#ttagaacg   2640
gagatagtat tttatgggta agaaatctat ctgtcttcag cttgaatatg cc
#tataataa   2700
agtattagag gggtgaccca atgtgtttta tggatttcat ttctgacatt tc
#taattcaa   2760
gcttttttga aaaacatttt ttatcacttt aatttataaa ctgtaggtaa aa
#ttcaggcc   2820
atttcagaca ttacttgtaa acacaaatac agtaatttgt tcaattattt gt
#tttatagc   2880
accaagcgat cctcccaaag atgtttatta tgcaaacctc agttcttcat ca
#ataattct   2940
tttctggaca cctccttcaa aacctaatgg gattatacaa tattactctg tt
#tattacag   3000
aaatacttca ggtactttta tgcaggtaag aactgaattt tcttctagtt ct
#ttattaac   3060
atccttaagt tttattaata atacagactt gtcacagtaa aagaaattgt tt
#accttaca   3120
ttgataatta ggcacagatg tattttataa aactcccatt gacatagaaa aa
#tgcggtgt   3180
agaaatgtca gatacattta atctctcttt acagacacac acacacacac at
#acaacttc   3240
tatataagct tcacatgtat taaaaatagt gaatctgcca cctactgaaa at
#tctgttta   3300
taaagatggc cctcaattac acttcctcca ataagtgttc tctaaagtgc tg
#atggtatc   3360
atttatcctc aaagttattt attagctaaa ttttttttca tttgtttgta ta
#tgatataa   3420
atagttctag tgtttggatg tgtttgtttt tctttaatta aaaaaagttt tt
#gatagcag   3480
gaagggttat tataataata gtatattagt agttaatgtt taatgtcaga tg
#aaatgaag   3540
accactcgga atgtgtttaa ttaatttgtc atagataaga ttctaggctt gc
#acagtttg   3600
tagatgggca ctctctagga tgtgaatgat gatggctatg aaaatagcta ac
#atgcattt   3660
actttgaaaa aatattttca attttcaaca gaattatatt atttcttcaa at
#tagatgtt   3720
tcacagaact ctaacatata aaaaggataa ttggaatgat tatgattgaa tc
#aaagatgc   3780
agagagctgg aatataatta gaaaaacacg gccgggcgtg gtggctcacg cc
#tgtaatcc   3840
cagcactttg ggaggccgag gcgggcggat cacaaggtca ggagatcgag at
#catcctgg   3900
ctaacacggt gaaaccccgt ctctactaaa aatacaaaaa attagccagg cg
#tcgtggca   3960
ggcgcctgta gtcccagcta ctggggaggc tgaggcagga gaatggcgtc aa
#cccgggag   4020
gcggagcttg cagtgagctg agatcccgcc actgcactcc agcctgggcg ag
#agagcgag   4080
actccatctc aaaagaaaaa gaaaaacacg aatttagaag aaatgctgca at
#gtacagaa   4140
tacatccctt agtggtagaa attattgacc acatgtttgt gtcttaggtg at
#tcttaatt   4200
atttctatcc ttttaagtaa aagaagaaga aagataagtc ttacaaattc tg
#agttacct   4260
aatcccattt gtgactgaca gcccaagttt agtcactagt tagctctact ga
#gtaacagc   4320
ctctgtaatt aagactttag tgcagctata gtgcaatgta ggctaatgaa ga
#gggcaaga   4380
gcagaacttg caagctatct caggactaac ctagcaggga gaaagacaaa gt
#ccagaagg   4440
tggtttagtg tttatattct gttctataag agtagggttg tataagtctg tc
#tatttaaa   4500
acttgatgca aagagaaaac tactttataa aagacatgta gatataatta ta
#gctgtaat   4560
gaaagacatg tagatatagt tacagatgta atcgtaaatc aacatttttg aa
#caaatgcc   4620
ttaagagcag aaggagaaag gaaggtctag ttttctactc tctatgtcac gc
#agtttttg   4680
ctttttgttt tgttctctgt agggaagaga aatggggcct agagaggcaa tt
#tatttttt   4740
aaccaaaatg ttgtttacaa ttgtaacaat atgtcattat acccatagaa ga
#tatgcaaa   4800
ttggagattt tccttctttt atgcatttaa aaaacattgc acaattgttc ca
#gtagttct   4860
aaattttagc aatcattttg tctctgtaca atttacttat ggcttctatg tg
#atttatat   4920
tttggttctc tttatccata tctaaataat atagcataag tatcaaacta tg
#gttccaac   4980
gtgatcttct aaacctactt attcacacct gggtgtgtaa tatgatctaa tt
#tgcaattc   5040
atctgcctta gaacatgtta tcttttatta aataatctta agaatgcttt ta
#agtgtgac   5100
agctgcaaga gggcacaggc taatgatgtt aaaatatttc agaagtatag tc
#tcatattg   5160
cttgaagttt atccgtgctt taacttattc ctaaagttaa tgttaaaaat ag
#catcaata   5220
ccttcactac ctaattttct attttgaatt agtggaagaa agcctcaaaa tg
#aaaattat   5280
gtagcagaat aagtgtatac ctttttattt gttccttatc atctttcccc tt
#cctacaga   5340
actttgtaga atatgtcatg cgtggcatat catgttctgc ctcctattac cg
#ataactgt   5400
tgcttctctt agttccctta tgccatgaca agcatcttgt agaaaaagaa tt
#gtgtaata   5460
tttatttttt catctccaaa agtcttctgc aactatgtca gacataggtt ta
#atgctcaa   5520
tacatatttt aattgaaaga tttaaaaaat attatagtag accaacatca ct
#tttagtac   5580
atagtcataa ttttggagcc cttgagtatg tagcaaagcc atctttcctt tt
#tcttatct   5640
tggagaattt aacctctttg ctactacttg gcaatccata ttgttcttcc tt
#cagttgtt   5700
gcacattgta ttttgtacag catattaact tttctacttt ttaagtttta cc
#cacttatg   5760
tttccttagt gtgcctggca taatgtcttc tattttaaaa agtgttaaat gg
#gccgggtg   5820
tggtggctca cgcctgtaat cccagcactt tgggaggctg aagcaggtgg at
#cacgaggt   5880
caggagatcg agaccatcct ggctaacaag gtgaaaccct gtctctacta aa
#aatacaaa   5940
aaattagccg ggcatggtgg caggctcctg tagtcccagg tactcaggag gc
#tgaggcag   6000
gagaatggtg tgaacctggg aggtggaggt tgcagtgagc cgagatcgtg cc
#actgccct   6060
ctagcctggg caacagagtg agactctgtt ttaaagaaaa aaaaagtgtt aa
#atgaatat   6120
tagttggttg gtcaaatttg aaaaagtttt actaaatacc ttctgactat at
#ttatataa   6180
acaaaagaat aagccttact tagataattt gtgccaaaag acattttgtt tt
#tgcaaaaa   6240
taaacagctg aataaaataa tcatctggat aattgattta atgttacaaa tt
#tgttacat   6300
gcctatgcac attaagtcac acagtcagca ggaatgactt ctgggtgatt ca
#gataattt   6360
gttatgtatt agccatcaag gtcataggta atcagaataa attctataac aa
#aaattaaa   6420
atttacatca aaaagctatg ttaatacttt taagtggtgc tttatataag cc
#agttgttc   6480
catgtgtaaa gtagatgtat tggaaggtat taaagttcat ggatcatatt tt
#gtgtgaga   6540
ttgctatatt actttaactt gtctatttct atgtaaatca ccacaaaatt gt
#agtaaatc   6600
ttttattgca ctatattttt ccctgaatac tggcaaaaga accataaaat tt
#tgctaatt   6660
taatttgttg ataaatttca gaaccattct tactataaat ttggtaaatt tg
#cttatcct   6720
atgttattca tttaaatgaa actaattact gttttttttt aattgtgtgc ta
#gacatggt   6780
attaatggct ttttgtgctt catgtcatct aatcctcaca agttgtctgt ga
#agtggaga   6840
tgattatttc cattttacag ttgaaggaag aaaagctttg agattaaatg at
#ttatccag   6900
gataccctga cagaatttga atgcaggtct ataggactta aatggcttca tg
#tggattgg   6960
aatgattcag gttactctgc agatggaaat tataaaatta ttcatactga tt
#agctatgt   7020
gtttaagtct ccttttattt tagaattaat tttatttggc tatatgtttt at
#ttttaaaa   7080
tttgatagga aagaaaatga ttacatacat accctaatac ttttttttaa gc
#cttgggga   7140
aaaatgcaac tgggagtcag tcaagagaat ttaaaacttt ctcttactct ac
#acatcaga   7200
gagtacatca gtctgctatc cctttgctac aactgtgaga agtaaagtct ga
#aaagaaat   7260
gtgaaagtct gaaagcccac taaatgtgaa taataatagc gatttgagtt ca
#tagaaaca   7320
ggcaaacaca ttcgaaattc cttcatcaca aatggaaaga aacacaatta aa
#agttttct   7380
aatactccca aacttgttta aaattagctg atgctttgaa aattacttga at
#gtttttat   7440
aaggaaagtg atgctgatca gcacagttgt agcatttcca tttggccact tg
#acattctt   7500
cattgttggc ttggagtttt tattctttgc tatttttttg tattggcttt gc
#aataaaaa   7560
ccaccatcta tttctctttt agtacaaaca tatttccagt ttaattgttg ca
#ataaaaaa   7620
tgttctatgt cgattttcct aaaacaacat attaaaataa tgataaataa ta
#aaatcgat   7680
ccattgataa caattagttt gaagtgttca tgcatactaa aaaaatacat tc
#tgaacaat   7740
gaatgtgttt atttttcaga attttacact ccatgaagta accaatgact tt
#gacaatat   7800
gactgtatcc acaattatag ataaactgac aatattcagc tactatacat tt
#tggttaac   7860
agcaagtact tcagttggaa atgggaataa aagcagtgac atcattgaag ta
#tacacaga   7920
tcaagacagt atgtaaacaa aaaacactaa tctttaatat gattaattta aa
#acttatta   7980
ttttaggaaa ttttactatt tgtttgaatt tgtaataaca tcttttattt ag
#acacgttc   8040
attataggag tttgaaaatg caattaatat acttacaaaa ctattgcagt aa
#tagcctct   8100
tctgttcaag aaaactgcta acatccattc atgaaaattc tgttcttttt at
#tgcttcaa   8160
aagatgtcgt ggccatccag ttatgggcac aaaaagtact gcatacatgg at
#gaattttc   8220
cagtagttaa tttatttatt cattttcctt aaggacttaa aaaatctcta gc
#aacttgtt   8280
ttcttttcag actttgaatc tacacaggac tctgcagcac atctcttctc ac
#tgtgtttg   8340
tgactaatat atccagagta ttttccttaa ctccagaagt ttctcgtatg ca
#tcttctga   8400
agaatcctat ttatcccgag tattcagaaa actataatga ttgaagatct tg
#atgttttt   8460
tatgtttcaa ttttcagaat acagtgataa gtggatcatt gcctattttt ct
#tgtagttg   8520
tttctgtcat ccatttgctt attttcaaag attaatccct tattgagaag tg
#gcagtgac   8580
ctaaacttct ggagtaaaac tccatgttta ttatctgaaa gccataaatt ga
#cagattcc   8640
ttaagcatga gaagtgaatg cttgatttgt tgttggaaca gtcttttgaa tt
#gttgacaa   8700
gttggtcaac ataaaaataa atgataaatg tggggaaata tgtatttggg ga
#gtctttag   8760
caaaaatgtt atattgtaat atatgatcaa taccatttca ggtattcttt aa
#atgcagat   8820
ctctcccagg atttttgcca acctatgaca ttttatcact tataatttcc ac
#accatgga   8880
taataagcac ttactatgca ctactccagg tggatgtcaa atttacgtta at
#agagttta   8940
atatcacaat acaacttata tctgagaatt ggaacttgtg tgtaagtaga gt
#aactttgt   9000
aatgtacaaa tgtgagttgg tagtctggtg actggagaga ttttgagact ag
#atcttggg   9060
aaagctttta gtattgattc ttctggctac ccacatgacc ttggagaagt aa
#cttaatgg   9120
ctgagcttta gtttcctcat atgtacaaca agggtaatat ttagaagaaa ta
#agctaaaa   9180
agatggttta aataacataa attatcaaaa tatttaaata aggcagtata ca
#tacacata   9240
ttatgcacac acacgcacac acacacaatc tccacatagt aggaaagaag ag
#tcaagaga   9300
atattataga aacaattccc atacatatta aagatgacag agtttatttt ga
#atgatttt   9360
taaaataatt atttagaaga tattttataa taggtgaatg tttgccacat ct
#gcatttaa   9420
ataatttaag agctgatgat gtaatagttg ccatttcaac aattatactc ag
#tttgtgaa   9480
tttagattct gtttagggta actgttgatt tttgtatttt gcccattacc ta
#tcatagta   9540
cctgaagggt ttgttggaaa cctgacttac gaatccattt cgtcaactgc aa
#taaatgta   9600
agctgggtcc caccggctca accaaacggt ctagtcttct actatgtttc ac
#tgatctta   9660
cagcagactc ctcgccatgt gagaccacct cttgttacat atgagagaag ca
#tatatttt   9720
gataatctgg aaaaatacac tgattatata ttaaaaatta ctccatcaac ag
#aaaaggga   9780
ttctctgata cctatactgc ccagctatac atcaagactg aagaagatgg ta
#ggctagac   9840
ccttttattg tctgttaagc agattgttgt tcttttcatt tacattgctt tc
#tgatagga   9900
aatagtcttc aattatattg attctgtttg atctcaagta attagccttt ca
#ataaacac   9960
agtgtttctt aaaataatct gctaagaaaa tcaaatccca ttatgattga at
#cctctttt  10020
tttaatgctg attcactttt gtttcattta atattctctt tttcttttat ag
#tcccagaa  10080
acttcaccaa taatcaacac ttttaaaaac ctttcctcta cctcagttct ct
#tatcatgg  10140
gatcccccag taaagccaaa tggtgcaata ataagttatg atttaacttt ac
#aaggacca  10200
aatgaaaatt attctttcat tacttctgat aattacataa tattggaaga gc
#tttcacca  10260
tttacattat atagcttttt tgctgccgca agaactagaa aaggacttgg tc
#cttccagt  10320
attcttttct tttacacaga tgagtcaggt aagccagaat ccacatttct tc
#aaacaatt  10380
tcactgttgc agcgcctgct ctctcttttt aaggaacagc atggaatatg aa
#aggatatc  10440
tgattgtcta tttgtaacag ccttaccatt atatttactt tgttgatttt tt
#ttttgcaa  10500
tttgagcttc agaatttcct gttctgttta aagctacttt ggaactactc tg
#tccaaata  10560
caaattataa ttaattatga tatttgtttc tgaaatttaa atatgatcat tt
#tataaatc  10620
tttttaaact agtgtcttca agaaagtaag tcacggtgct atttttatgt ta
#aaagtttt  10680
atgaatgtaa gtttcttcat gtgttttcct acagtgccgt tagcacctcc ac
#aaaatttg  10740
actttaatca actgtacttc agactttgta tggctgaaat ggagcccaag tc
#ctcttcca  10800
ggtggtattg ttaaagtata tagttttaaa attcatgaac atgaaactga ca
#ctatatat  10860
tataaggtag gttgattata acagtatatg tttattttta aaaatcagaa at
#tgaattaa  10920
aatcttttga catataggag gaaaatggac tactaaatta aacaatgact at
#ttttttaa  10980
acttctttat ttcctacaat ttaaggatgc ttatggaaaa cacaagcaag cg
#tttgacag  11040
gtatataagc tgaatacttc atagagcaat gtacttagat ttgtaacttc ca
#gatatcta  11100
caatttaaga aacagttgca tcattttgtt aatgctggaa agtgtatagt ac
#ttttttcc  11160
tgacttacaa atataaaatg tatttctatc tattgttaac agcagcacca ag
#ggaatctt  11220
tttaaccttt tagaaaggta ttcatcttta ttctggactt ctggtcatct tt
#ccagatag  11280
catatgatcc tacactaatt ggtcttttac gatatatcct tatttttttt tt
#tattttca  11340
agagtaattc atttgcaaca ctaaccacat tttccctcct ccatttttgg aa
#ttcagaat  11400
tagtgaaaaa tatccacaga actgatgcaa caaagagtct caaatatatg tc
#tgtgattt  11460
ctagcattta attgccaaaa tgtaattaac aagcatttat ttaagaaaag tt
#tcttattt  11520
ttttccccaa aggcaaatga agtcctggaa tgttcttatt tagtttacag ca
#agaagagt  11580
gcaaaaaatc tgcagtaaat attttactca atattatgag tattacaatt ta
#tgactatg  11640
gtaaatcatt gttatagcat atgtagttta caaattgaat agtaaaagtc aa
#aagcaggc  11700
attaacttta tgtcatcggg aacaatgact ttctttctgg aaaccaagat at
#tactttaa  11760
aacttgatag tctgagtata atttgaatcc tattactcca taaatgtgaa at
#ttgtttcc  11820
cagaggtgtg aaataacatt aaatgacatg aagcctcttg ccctttaata tc
#tatccctg  11880
gtttaatctt aacattattc cattttttat ttgctttgtc tgtatgggtc ac
#tgggagat  11940
agatatcaaa aggaaaaaag aatcattttc tcagagtaat cgcattccta gg
#ataattgt  12000
gtacgtgtgt tagagtgtgg ttgtctatat atggatcttg tctcctcaga at
#ggtgatct  12060
gtaacatagg ctctcttagc atagcggtga agcaagggct ctgactccaa at
#tacctggc  12120
tcagattctg cctttgagac ttactgtgct tcagtaggga cattgcttac ct
#cttaatgc  12180
aaaatgggag ttacaaagat gtgtacattc gaaattgagg attaaaaagg aa
#agtctcca  12240
tagagcattt tgaacaattc caagcatgtg ataaatatgt tagctattgt tg
#ctgtaatt  12300
gtacacagtt tttaaaagaa caaaaaaact gtccaacatt gtaatagcac ta
#agcatgaa  12360
atgacaatat gccattatgt gaacatgaga ataacttgta ttctaagatt tg
#taaacagg  12420
ttttctcaat agaagcacat ctttaatatt tcagaagtag caaaaatacc at
#ctttatac  12480
cattaagtat tcaatacatc atttgggatg ggcagtagtt ttgtgtttta aa
#atctactg  12540
cgtcatgtta ctccttttta catctatttt ctctttcatc aattttcata at
#cttatttg  12600
ctttcaaatt cctttaaatg tactctcatg ccatcttttt ccctgtcttg gc
#atctagtt  12660
actatatctg ctttcctttt tctatttcgc tttctctcct agtgtgttct at
#tttccttt  12720
ctctttcatc taccctgata tcctgacagt atcaatttat attattttct ct
#gtttttct  12780
attctttttc ttcttttaaa ttatgtgtgc atttgtggag gtagaataat gc
#ttgaacca  12840
cttcaaatgt tactgctatc ccagtcaatc cactgtggtc cacagataat aa
#aatcaata  12900
ggtgacttag gtcactcaca catactgaaa gaaattattt atttagtaca aa
#gttctatt  12960
aaaatatgtt tgtaagtatt catcactcat gtttctcttt ttgacaacat at
#tcttgtgt  13020
aaatctgttc actatcccat aaactattct cttattatta tgccctcttg gg
#ttcagttg  13080
tttctctggt ttttagccct tcctaaccaa aatcataatt tgcttgtttt gt
#gtttaatt  13140
ttttctcatt cagaaattgt agatttctct agttaatata aaaattcctt ga
#tggcaggg  13200
accatgcctt acatgtgtct ataatctcca gattatctaa tggcatgttt tg
#taaatagt  13260
aagcaggaaa gaatgactga aataaagaga ttcagtaagc ccctaaattc ag
#tgaatttc  13320
tagagattat tttaaaatag gattctaatt gtaaattccc caagaattaa ta
#ttcttgtt  13380
aaaatttctg ttactgtgat gtttgataaa tgatcaacat ggtttatatt tt
#gtcagata  13440
taatgtaaga ttcctacatt tatatcacat aggagattat cttctctttc ca
#tgaggata  13500
gctgattaat cttagctgct ttcttggtta ggacaattat ctttgaatga aa
#actttgta  13560
cttaatgata atttttttct atgagaaagc atattcctcc ttgggcaact at
#gatactct  13620
tttgttcctt ttctcatatc tctaaaaaca gtgtcaaatt agaaatagag ga
#atcggctg  13680
ggaaaactcc caatttaagc ttcatggaag cagatatttt aaaattatta tt
#ttaaaata  13740
ataataattt attattatta tatataataa tgttattatt atttattact gt
#tttgccag  13800
tgtctacata cagtagctga agaataaata aatttacaca ggaatgctgt gg
#gtattaaa  13860
aatgaattta gataagttca gaaaactcaa gtatctctga ccatgcacaa gt
#tggattta  13920
aattgcagac tgtaattatg caaattaaaa aaaatgagta tataattcca ag
#tgaaaatc  13980
atgaaaataa aacactctag ttttttaaaa aggcaattat acgccaggtg ca
#gtggctca  14040
cgcctgtaat cccagcactt tgggaggccg aggtgggcag atcacctcag gt
#caggagtt  14100
caagaccagc ctggccaaca tggctaaact ctgtctctac taaaaactac aa
#atattagc  14160
tgggtgtggt ggcacatgcc tgtaatccca gctacttggg aggctgaggc ag
#ggagaatg  14220
gcttgaacct gggagtccac ctcccactgc actccaacct gggcaacaaa at
#gagactct  14280
gtcaagaaaa aaaaaaagtc taaaaaaggc aattatgagg ttcttcaggg aa
#aagaaggt  14340
gcccaattca tccttgtatc ataaactgag cacactctat ggcacaaaat aa
#atgctaat  14400
atttgtttta ttataattta aaatatccat gcttattaaa ctataggtta aa
#tataaaag  14460
gaataacttc aatgaaaata ttccattgat gaacaatttt ttgacagtgc at
#taactaat  14520
aacttttttt ctgtttttca gaatatatca ggatttaaaa ctgaagccaa ac
#ttgttgga  14580
ctggaaccag tcagcaccta ctctatccgt gtatctgcgt tcaccaaagt tg
#gaaatggc  14640
aatcaattta gtaatgtagt aaaattcaca acccaagaat caggttagat ac
#agtttttg  14700
agcctaaaat gtttcttttt atatttaaca cctttctttt ccttttctta gt
#ttatatga  14760
taaagtatca ttacttaaga gtctactcaa agggaaattg catttcagtg ct
#ttacgttt  14820
agtcttggtc ttgtgtgaaa tcatatgctg tatgtgtgtt tatacatata tt
#ttcacaca  14880
tggtttttcc ttttgaacag aggaagttga aataaaatag tagtttggga ac
#aaaatagc  14940
cttctagata tctgtgaaaa ttacctaatt cttagaactc tttgagacag ct
#ggggaaaa  15000
agggggaaat gaactagcag tcacttttaa cgggctgatt tatattttta at
#gaaacaat  15060
atctataatt ttcttttaag aagattagtt gtgacatttg gagagcatga gt
#cattgcat  15120
aagcccccta tgttcccatc atcccatctt taccatgtgg cggacactga aa
#tatcattg  15180
gtctaattca tcaacagctt acctgctgtg tcacacatgt agtatacatg ac
#atatcttg  15240
cctttgtgtg cacactgaat agtttttatt taggacctat ttaatgatgg ct
#tagaaatg  15300
tacttttcct tttctcaact gcaccatacc tttaaaagca cctcttctta at
#tttttttt  15360
tgtttacttc tgtcaatgtt tattgaatga gcaaaagatc ccgttctagt ca
#tttcttct  15420
tatcagctct ggatgcactt cctggtatgt tagtgaatct ttaaatcgag at
#tgtagacc  15480
actgactact aaattaatca tttctgcata aatttatggc tacctgacac tg
#tttttcgt  15540
gcatttctgt aacaaatgca aaataaatag catttataat ggataaaagt ac
#atgctgtg  15600
aagtcatttt ctggatttga atttgagccc catgacctac tagttgtata at
#cttggcaa  15660
aggctcatga ctctgtgagc ctctgtaacc ttaactgaaa agaagcacat at
#tagcagta  15720
gccatctcat aatgttgttg tcaaaaatat ttggaaagat ccacataaag ca
#ctttatag  15780
agtgttgtac acacagtaaa tgcccacttc atagagtgtt ggacacacag ta
#aatgaccc  15840
ctgaatatta ctgttgcccc cattcccatg ttacagatga agaagccatg at
#tgagctag  15900
attagatgaa aaggaccttg aaaaaattag tgaagaacct aactagaaca tt
#ggccttct  15960
gacttctagt gaagagtgga catgactgca ggaaatgcat gttgtgaatg ag
#tgatagaa  16020
tataaaaatg ttcaacccat aaataaaaaa atattttaat aatatttgta ca
#tgaggaca  16080
ataagaatca gggctaatct tgtagaaagt gctctgtaaa cccataaata tt
#ttttatca  16140
gtaagataaa attgtacccc aacattctat actctgatta tttaaataaa ta
#aaattttc  16200
acctttaagt gttttaatat caatggttaa tttttttttg aggttcaaaa aa
#tcaggaaa  16260
atggatattc acaaaatctg gatttagaaa ctaaagttca gcaaattgtc aa
#ctatctta  16320
tgttaactta ttttataaaa atgttcttat atgattctga aaacaaggaa gt
#gaatagtt  16380
aatagcattt aattgccaga tcccttgatc agccagaaat tatctttaaa aa
#atttttta  16440
atgccacata ttccctaaat attctccttt agtactggtg tctttatctt ac
#agaggaag  16500
aaaagtttat aacagctcag tttagaccca ggtagagcgg tgtaggcaga tc
#agggatca  16560
cctgagtatt ctttaaagca ctatgttttg cataatggca gcaagttatt tt
#ctttcaat  16620
tttcattgtt tgtaatccac aaattgactg tgtcccaatt tttcttctac ca
#ttatcttt  16680
tactgtgacc agaaaagtta ttctactaat gccaccatta ggggacattg gc
#taattgga  16740
catttctgtg ggaagtaacc agtttctcta atgtgcagtc actttggtgg gc
#taggatat  16800
tgttctttga ccaggcctac cagatataga ggacctctga gaagctgggt ta
#gtttcaag  16860
taaattcaga gaagctctag aaaataagac tgagactcct taaatcttcc tt
#ccaatgat  16920
gtctacaaaa ggtacttaaa aatgaaatcc tcaagattct tccaaagaag cc
#atcccggt  16980
aaaaaccagt acctttaaat tagttagggg tttccaagta ctgtgaagcc ca
#gatttgtc  17040
acaacaggga ggcacctgca tactatgttt tgcataaaaa tgttccataa ta
#aagtattg  17100
ctaagatttt tcctttccaa ttaagagagc agttatcaaa cactgcctgg gn
#nnnnnnnn  17160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntaagagagc ag
#ttatcaaa  17220
cactgcctgg gcctgggctt gaggctacac atttgcttct gagcttttga gg
#atgtgatt  17280
ggtgcttcga actggaagat atttagtgac tggttcaata ctgtaatgat ta
#atacaata  17340
gcataaaaag caagtcaaca gccttttgat tctgtctatg ttaatgactt tt
#taagcaca  17400
cattgaaaat ttgatatatt aaatattttt ctagttctaa acacagatgt at
#ctagtgat  17460
cacgtaattc aatcaattat ctacttacat atgtatacac tttaactttg gg
#catatgtt  17520
tatctcttaa gttccagatg tcgtgcagaa tatgcagtgc atggcaacta gc
#tggcagtc  17580
agttttagtg aaatgggatc cacccaaaaa ggcaaatgga ataataacgc ag
#tatatggt  17640
aacagttgaa aggaattcta caaaagtttc tccccaagat cacatgtaca ct
#ttcataaa  17700
gcttcttgcc aatacctcat atgtctttaa agtaagagct tcaacctcag ct
#ggtgaagg  17760
tgatgaaagc acatgccatg tcagcacact acctgaaaca ggtaactaac gt
#gaaacagg  17820
taactaacat gaaaccttta actatttggg gattgtgtca ataccacctg ca
#atctttat  17880
agcatactta tctaaacata caaagcacat attaaaaaat acaacacagg ct
#ttttatcc  17940
cacgtgttgc ttgagtgcca gctgtgtact acattgaccc ttctccaaaa ca
#ttgggaga  18000
ttgaagggag gaaaaaaaga gagatgatcc tctttactgt atttccacaa at
#ataaaacc  18060
cccacctaat gaattatgct ttattgtgat ttaaaagaag aaataaacat gt
#aaaccttt  18120
catgtatatc tctttttagt cttacttgtt tttatggaat tctagatgtt tt
#cctgaact  18180
atatggttgc agtatcagac tcattttcat ctattttctc ccctttatac ca
#gcctttat  18240
ctttcatgtt atttgaataa aatatccggg tcgttaagct ttagtccaca ag
#acgaaatt  18300
ctcaccttcc ctagcagtgc tctgtcctgt atcataatat ccttcatcct at
#tttcttcc  18360
atattctacc tgcttatata aattaaaacc tgtttctttc ctgataacac ca
#cttcactg  18420
tagatattgg caataattgt taacttctgg cacatccaga ccctttatct tg
#gaaacgtc  18480
tttcaagctg tcttgaggct gtaaacctag aacatcaaga catagtctgc ct
#tctctctg  18540
atttcagcat ctaactccac atcctttcct tctcattctt ccagtgcaac at
#tttttcag  18600
actacggtgt ttccctttcc aggatggaat agttacattt caacaacacc at
#ctctttgc  18660
tccttagatc tcataccatg tcattgtgac ttaccctcca ggaagcttcc tc
#actctgag  18720
aaggccccat tatttgtttt ttccaagatg ctgactggta aatatttcta gg
#aaaaaata  18780
gaaatgattc tactttgttt gtctataaat tcatcgtcct taattgtccc ag
#ctgctcca  18840
aaattttcta tgtatccctt gtttattctt cataggaaat atgttcatag ga
#atactctc  18900
tattccatat gaaaattgtt ctctttctga acctagtctg ttcccccatc at
#ccatattt  18960
attgttattt tactaataat atcaaatata ttgataggcc ctccttccat ca
#aaatttat  19020
ccatgtcttt atttatgccc tccagatatc ttctcttagg aagtccttgc ct
#tcctcttt  19080
cagggatcta gctgttcatt ttcattttaa tcttatgtct tctctaggat at
#taccccat  19140
caatttattc taatatctcc tgcatttatc ctctttctct ttttcttgca ca
#ttcaccca  19200
aattgttgaa aaatcccaac tgaagaccta gttggagtat caactccaaa ta
#tatatgaa  19260
atggaatttg tgttacatga aatcactgtc tttttcttag ttttctatgc ct
#gttcttga  19320
caatccattg gaccccaagc ctcatagttt tatacaattc cttactccat ct
#cttctaca  19380
tacaatcagg tcttatcaat tcaatttcca tcagggctct gcaatttgcc cc
#ttctccac  19440
cttggccacc accattgtat attagaggga ccttgttgct tcctgtaata ac
#atcttaac  19500
tagccttatc acccacacta ctttagccta cccataagtc tcatctttcc tc
#ctactcac  19560
ttaattgaat tggttctaac atacaattag accatttata cattggcagg tg
#aaatgtaa  19620
tatctgaaca ataaagttta gacgtgtcaa gttgggtacc tgaagcacag aa
#gtaataat  19680
gaaaggcacc atgtgtagga gatgggttaa aatactccaa atattttgct ca
#ttctcatt  19740
gtctagaaaa tatcccagaa tccatcgcta attagaattt ggcttctctc ta
#gcttttta  19800
ttcttatatc cttttattgt atcttctcat atagctgatg tctccagcca aa
#cttcattt  19860
atttagcatg ctatttcact atttcagtat tttaactcag aaaacattta tt
#aaacatct  19920
agtatgaact aataattgac tagattctct tctttaaaca tatccaacca tt
#tttcatca  19980
tcagattgct ttgcttcctt taactgtatt attattttcc ctttctatga ca
#cataaaat  20040
tttattcatt tttaaaagcc cagcttaaat gtgccttctt tattaaagcc tt
#taatggca  20100
tttctggact tcatcccaga cttgctgact catagcctca atgagtgaag ct
#taagaatc  20160
catgcactta agaatctctc taggtaattc cgatattctg tatgtattgg ag
#agtactgg  20220
agtagattac caggaacttt tgaggacagg caaagagtgt cagaaaggtc ca
#tcaagggg  20280
tgacaggtgt tttcccagtg ggtggccagc acatcattgc tatgtggagt ct
#gtgggaag  20340
aaaaaatgtc aaaatgtcaa aatccaggta ggtggtctgc atcagggtgg tc
#tagcacca  20400
ggtataatgg tcttgatcat tgggcaggag ctgagtcttt gagaactggc aa
#ataaaatt  20460
acaggacaac atatctgaaa taaatgagag attcaggaac aaggcaggag at
#actaggtt  20520
ggtgcaaaag taactgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  20940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  21960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  22440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna tt
#tggtttta  22500
aaaacttggt cttttgtgga agataatttt ataatttggg tttatccaga gc
#tcttccaa  22560
gctccataat ttagaatcaa aagagaaaaa taaggtactt ccctcagatg ca
#aaaattta  22620
atttagggaa agtaaaatgt gtatttctgg tttttagggg tgttcttttc tg
#cagtgatt  22680
tctttattag ctttttgtcc agtggaagat atcaggcata tgcagtgatc ca
#ctggaaat  22740
ccactgagct tgcaaatata ttaatgctac aatatgattg acttggcatg ta
#ttcaattt  22800
aattatcatc atcatcatca tcatcatttt agagacaata tcgcactatg tc
#accgaggc  22860
tggagtgcag tggctttatc tcagctcact gtagccttaa cctcctgggc tc
#aagtgatc  22920
cttctacctc agcctcctga gtagctagga ctacatgttt gcaccaccat ga
#ccagctta  22980
ttttttgttt gtttgtttgt ttgagacagg gtctcattct cttgcccagg ct
#ggagtgaa  23040
gtggcgctat cttgactcac tgcagcctcc acctctcagg ttcaagcaat tc
#tcgtgcct  23100
caggactccc aagtagctga gatcataggt gtgcaccacc acacctggct aa
#tttttgta  23160
tttttagtag agacagggtt tcaccatgtg ggccagtctg ggtatcgaac tc
#ctgacttc  23220
atgtgatcta cctgcctcgg cctcccaaaa tgctggtatt acaggcgtga gc
#caccgctc  23280
ccagcctgcc cagctaattt tttatttatt tttgtagaga tagtctcact at
#gttgccca  23340
ggctggtctc aaactcctgg ttcaagcaat ccttctgctt cagcctccca aa
#gtgttggg  23400
attacaggca tgagccacac acccaatcta gcttatttgt taaatacatt ac
#ttatatat  23460
tttataagaa tttataaaat tcttatatac catttaatag attgaatgtg gg
#cagtaaaa  23520
ctgctgccct tctatggcta caaattagtg cactaaatca aaagttcact tt
#tcctttgt  23580
atcctactta catagctttc ctcatccatc tcctgaatta agatttgaaa ta
#aaggatgt  23640
aggaaagttg catgattctg attgctctca agcaagtgaa taaaaacatt ca
#acttaccg  23700
gtgggtaatc actagaagca caaaagacat tatagttgcc tatcataaat ca
#gagggaaa  23760
taactattag tatatctaat tgaaattcag gtgttttata cagtatcttt ta
#tatagact  23820
taattattaa atataatatt tttcttcagt gtgaacatca ggtgaggaat ct
#ctttttac  23880
acttcttgta gtgcagtgga cagttgacca atatatactt atttactgct tg
#ctatgttc  23940
aggttctagg tgtggggttc aagacccaag tttgagtgcc aggtggcatt gg
#ggatcttt  24000
gccctgcaca tccaaataac tccattatta taataaaaac atatttaata tg
#tataaaac  24060
aaacacaaac ctacataata tgttggtcaa ttnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  24600
nnnnnnnnnt ttatcagtat gctatgagaa aaatggcaat tgtacatatc aa
#agaacatt  24660
tcctctttta ttggaaatat tcttggatgg ttaggttgag atcagaagag at
#tatgggtt  24720
gactaaagca ctcatggtaa gctgccctcc gacaccctca ctattcatga aa
#atagtgag  24780
aatagtagtt agaggagaat aaataggaat ttcaagatac agcaagagaa aa
#cacatagt  24840
ggagaaagga atgcagtaca aggggtcagg ctgagaccaa agcttgacta ca
#gaggaggg  24900
tattttatta gaaggagtgt aagcaggaag gttgaataac tgaagtggac cc
#ctacttac  24960
tctgctctta gtttgatgtg actgtcccag aagtttgaat ctgttataat ag
#aaaatcag  25020
gaacttgtgc taaatttaga gaaggaaaca acataagtaa ttctaaaaac ag
#tgattgtt  25080
tttggccatt ttcctgaaca ctgcagaaat ctctttagat ggaggatttg tt
#cattacat  25140
atttactgag cctcctaagt aatacagaat aaaatctcca gtcatttcaa tg
#gcccataa  25200
agcccttctt ctcaatccag ttatctgtca cttcccttat cttgaaattt at
#gctcaaat  25260
gctacctctt caaaaaggat ttctgactaa tttgcccttg aacgtccttc ct
#cccagcta  25320
gaattttcca tactcctttc ctgctttact tttctctttt ggatatatta ta
#tgtaccat  25380
tatctgtggg tctgttctca catgctgcat ggggacagag atttttcttg gt
#tcaaacct  25440
atttccaatg tccagaaaag tatctggcat acgtgataat aagtatatta ta
#aatgaatg  25500
aatcaatcaa tgcacaggcc aagaagagtg ataggcatag agcaaacacc aa
#gtatgcat  25560
atgctgggtg tcttaagtag aaacttgcag tcacaaaaca atttttaaac ag
#ttatgtat  25620
taaaacatat gagaaaggca tgtcttgatg aatnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  25680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  25740
nnngtttcac catgttggcc aggctggtct tgaactcctg agctcaggca at
#gtgcccac  25800
ctcggcctcc caagtgctgg gattacagac atgagccact gcacctggcc tt
#tttttttt  25860
tttttttttt ctttttggta tggatgtacc acagttccct taaccattca ct
#agttgaag  25920
gacatgtgag ttgtgtccat tttgtggcta ttagaaataa agcttctata aa
#cacacgtg  25980
cacaattttt gtaggaacat aaattttcct atgtctagga tatgcactga gg
#agcacatt  26040
gctgagtcat atggtagttg catgttaagt ttttttaaga aactgacaaa ct
#gttttcca  26100
aaggaattgt acccctttaa attcacacca acaatgtatg agccatccag gt
#tcacacat  26160
aggtgtataa tgatgtatca ttctggtttt gtgtttccct gatggctaac gt
#tcaatagc  26220
taattgaata tattttttat gtacttatgt accatctgta tatcctcttc ta
#tgaaatgg  26280
ctgttcatta cttttgccca tttcctcatt ggattgtttt gttttattgt tg
#agtttggg  26340
gacattttta atacattcta gctacttgtt tttgttagat atatggtttg ca
#aatgattt  26400
ttgccaggct gtagcttgtc ttttcttttc tttcttttct ttttttgaga cg
#gagtctcg  26460
ctctgtcgcc cggggtggag tgcagtggcg caatctcagc tcaccggaac ct
#ccgcctcc  26520
cgggttcaag caattctcct gccccagcct cccgagtagc tgggactaca ga
#cgcgtgcc  26580
accatgcccg gctaattttt tgtattttta gtagaggcag agcttcgcag tg
#ttacccag  26640
gatggtctca atctcctgat ttcgtgatcc gcccacctcg gcctcccaaa gt
#gctgggat  26700
tacaggcgtc agccatcgcg cccggcctgt agtgtgcctt ttcatcctgt ta
#gtagggtc  26760
ttttacaaag caaaactttt taattttgat gaagtcctat ttatcaattt tt
#tcttttat  26820
ggattgtgtc tatggatgtc taattgctct agcaccactt gatgaaagag ct
#gtctctcc  26880
tccattgaat tgctttttct tttgaagctt agtatgttgc ttgaaactat gc
#ttgttaat  26940
actgtatact gaaaacgtac aaagaataat gttccaattt aagttagatt ta
#agttaatg  27000
atgttcatta ataaggactc ttcagatata aatattccag aatttctctt ag
#ctttctaa  27060
tcaaaacaac catcagtgaa tattacctta ctttggaagg tatagatata ca
#tttgaatt  27120
aaatttagtt tttccaaata acccctaatt tgagaaatat attctatctt ga
#aactaaaa  27180
taatttaata caactttatt ttcttccctc ccctcccctc tcctgtccac at
#tttgtaaa  27240
atctggtcct gaataagtca caatataaaa ataaatgtac acttaacttc ca
#cttcctcc  27300
aaccacaggc tactttctgt tcctcaacct tgggaacaag gtgaaaaaca gt
#aagcaatt  27360
tgggcagggc attgccaaaa caagattcaa gcagccacat gtggacacct ct
#taaaagaa  27420
tttggggaaa cgagaccaaa gaagtcaggt ttgattttta gtgacaataa ca
#aacatgaa  27480
gtgactcttc ccaagtaaga gtgccactgg gatgtggcct ggccacatgc tt
#acctatgc  27540
tatacttccc aggaaaccct gatgctctgc tccaggagag acctttatcc tt
#tggaggtt  27600
cagtgtcttg ggagctcttt gattttgtca aagagatgag cagagattcc ct
#gtgggtat  27660
tttaaggctt ggtgtcaagg tatttttctg acactgctga gcaaagtcca tg
#tatcaaat  27720
gatctgtttc tagtttgttt aaattcttca catcacttgt agacctaaca tg
#gcaaagct  27780
tcattattta atcataataa cacctactac ccatactaac ttatgattta tt
#ttctgtgc  27840
ctggaaatag tctctgtgtt taacaataat acctggatgc aaaacaatcc ac
#tgttatat  27900
ggccacaaaa tattaatgat cttctgaagg ccaagaaaac attttaacta ta
#gttcttgc  27960
acagaaattc acacccagaa tccccaaaat taaaaaaaat ttggacaaca ca
#aataatag  28020
tttaagatac acatacatac aacacagata ctcttacaca taacatcttt ta
#cggaaatg  28080
tgtttagtga aactgttcat ttgttgacag ccacagaagt catattttgc ta
#aatagctg  28140
ctccagctgt ttttttcttt ggaaaatgta tcactatagg ataccctgtt ta
#ttgcataa  28200
gataaaagaa aaatatgttg tgataaccaa aaagttttaa gggctttcaa gt
#tatgtaaa  28260
aatggaccta tggacatggt taattgtcct caggatgcaa aattggagct ga
#aatagtat  28320
atcaaacaat tgcaaaaagt gtactgcagc tatctcttgg gtcaaatctg gt
#acccagaa  28380
atggagaaaa gcctcaagaa acattgctgg ttggccctct gccacttgac tg
#tatgatct  28440
gatcacatgt aagtttcaca aacgattcat atttctctgc tagtttgacg tt
#gagaattt  28500
gctcataaac ctccctaatt ttatcttctt ggtcctttga gaaacacata gt
#atcccaac  28560
ttgtcagaga ggaaatttga gctggtcctt ctttatccag gagagacctg aa
#aaattagg  28620
tggtgtgagt actgcagagt gaggctgatt ttccaaagca ctaactttgt tc
#tgattaag  28680
aacaatttac aatggtctcc actgctggta atgattatct tcttttacgt tc
#tgaaaaat  28740
ctgctctggc tgggaaggtg ctgctcactg ccaggtggga tgggntgcca ta
#cctttgga  28800
aaaccatggc ttagcagtgc cacctccatc tccatggttc actccagggt ca
#cccaccgg  28860
tcatgccatg ctgttgaggg gcagagacct ggagcagaca ctgatatgac tg
#cctgcaca  28920
gccactggct tctcggtggt attcaaacgc caagccattt tcccatactc tt
#tgagtttg  28980
aggaactttt tggagattgc ttgagattct ctgcgtagaa aatcatgcca tt
#tgtaaaaa  29040
gggtcagttt tgcttcttcc tttctcatct gtatgccttt tgttttttct gt
#cttactgc  29100
actgactaga aatttagctc tatgttgaat aagagcaatg aaagaggaca cc
#cttgcctt  29160
gttcctgatc ttgagagaaa gcattcaatt cttttaccat tgtttgtgat gt
#tagctgta  29220
ggttcctctt tatcgagttg aggaaattac cctttacttg tatttttctg ag
#aattttta  29280
tcttaaatgg gggttaaatt ttgtcaaatg cttttttttg cattgattga ta
#gtattctt  29340
gcaatttttc atctttgctt gttaataagg tggattatgt tgattgatct tc
#taatattg  29400
aaccagcctt gggattctta cactgcttgg ccatgatatg catattccta cc
#ccacttgg  29460
cattgatgta tgtgtatata taactgattt ctatttgatg atattttgtt aa
#ggattttt  29520
gcatctatat ttatgaaaaa tactggtcag tagtttgctt ttttgcactg cc
#tttatcta  29580
gttactgtat aagagtaata ctagctgtgt gaaatgaatc tcttctaatt tc
#taaaacag  29640
attgtgtgga aatggtattc atttatcttt aaacaattgg gagagttctc ca
#gtgaaact  29700
atctgaactt agagatgtct ttttggagaa ttttaaaatt acatttttat gc
#tctcagga  29760
tgcaaagttt gagctgaaat atactatcaa acaagttaga aaaagcaaca ct
#tctcgata  29820
attcatagat tgcaaaggaa atcttaagat aatttttaaa atacatcaaa ct
#gaatatgc  29880
taaaatatat tgaattgaaa tgaaaattca acatatcaaa atttgtgaga ct
#cagtgaaa  29940
agaaagaaat ttgtagcact aagtgaatat atttaaaaag agaaaataga cc
#aataatct  30000
aaattccctc cacaaaagaa agcctagaga tagaaaaggc agagaatcca aa
#ccatgcag  30060
aaggcaggga ataataaaat gcagaaatca atgaaattga aaacagaaaa ac
#agtaggaa  30120
aaatcaatga aatgaaaagc ttgttctttg aaaaaataaa taaaattgac aa
#atctctag  30180
caagcctgac aaagaaaaaa agagaaaatt caagaatgaa acaagtgcag ac
#actgcaga  30240
cataaaaaaa aaataagaga atactacaaa cagctctcac agttaaattt ta
#tatatgag  30300
atgaaatgta ctgattcttc aggaaacaca cctactacac tatactccct aa
#tatgaaat  30360
aggtaatttg aatattttga acagttgaat aaaattaata ctataagtat ta
#aagacatt  30420
aagtgtataa tggtttcttt gtttgggctg ctataatacc agaaactgga tg
#accgataa  30480
acaacaaaac tttatttctt acagtctgga agctggaaag tccaacatca gg
#gcaccagc  30540
agattcagtg cttggtgagg gcccattttc gtgttcatag atggttcctt ct
#tgttgtgt  30600
cctcatatgg tgaaagggat gaggcagcac tctgcagcct aatcccactc gt
#gattactg  30660
ccctaatccc actcgtgagg gcagagccct catgagctaa tcccactcat aa
#gggcccta  30720
atcccactcg tgagggcaga gccctcatga gctaatcacc tcccaaaggc ct
#tatatcct  30780
aatgtcatca cactgctgtt taggtttcaa catatgaatt ttggggtgat gc
#aaatattc  30840
agaccaaagc agttttcttt tataccactc tagtagagaa agggaggagt ac
#gtctgtta  30900
ttgccaggta ggggtagaaa tccgggtttc caacttgggc tttgttatac cc
#aaggagag  30960
gatttctcct tgctcctggg ttagcttggg atttttggct ccctactaag tc
#tccactgg  31020
gatcaccctg gttgggagga gtagtgatac cttttcactg atgtccacat gt
#tttccatt  31080
gacattatgg tggaagggtc ttattactan nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  31620
nnnnnnnnnn nnnnnnnnnn nnnnnnncat ccatgggtat attttgaata tc
#aagcaggg  31680
atacttttta tccatctatt caagatcaag ttattaaaca catattaagt gc
#tgtggtag  31740
aaagtattgg gatgactgta atgaaatgaa tatatttctt gtgctattaa ag
#tttagaat  31800
tatataattt tagatcttca ttgaatctca tagataactt catttagtca tt
#tcattttg  31860
cagacatagg aaatgaagca cacaactgaa gtgtttgttg agttttctac aa
#ttaattat  31920
ttgcaaaact attactagtc cagaattctt tctactatat tgtctcccct ac
#cttagaaa  31980
ttcaatacat cattgtgttc attggaatta caggagtttt cttccattat tt
#cacaatgt  32040
ctaagtacag acattatgaa gtagggaaat ttactttcat tataaaactt tc
#ttcattaa  32100
catgtataga tacatttata atgtgagtat atacatactt ttgtccaaag tg
#gatttaaa  32160
attcaaaaaa aactaaattt ctatgatcaa atccatgctt agtctataaa ac
#taaaaata  32220
ttgtgagtta acgtaataag atctgtaaaa tactgaggcc attatgggaa at
#gtttaaag  32280
ttcctacatt catatcacat tttttatctt ggatcagttc caaaagtgta at
#gtttgcta  32340
ttttgaaatt atcttaggta tcaaattcca acttataaat ttaaaagttc tt
#taaatgta  32400
attcctttta taaaaagtga atttgggtta ctctgcataa ttctccttga cc
#ccactgat  32460
gctttaatat ctctcattaa gtggactcca ggcagccact ctttgcttta tc
#caagctcc  32520
agctaaggcc agctgttctt tgagcagtgt ttttattaac ttatttagga ac
#tggtgcat  32580
atcttattac cctattttcc attcctgtcc tatgcagctg tagttgatac tt
#ttcataac  32640
agcctttaca tatcaacctc ctcccctatt ttttttctta ttctctttta ct
#tccctttt  32700
taagtaaatt aagcatgtgt gtgcatgcaa aagccctctt ctttctttct gg
#taaccata  32760
tgacgtgaaa gcttcaggaa tgtgcctgtt gtttgtctga gattataaac gt
#catggaaa  32820
aacttttact aatgatgtaa acattcagaa atgtagaata catgaatttt aa
#taatagca  32880
aaatttcttc aatgttgcat ttaagaaatt aatttagacc taatttaaaa tc
#aatgcaat  32940
gtaaatacaa agaaaaggat ttgaacagat agaagactgt acaaaatact ac
#taacctca  33000
gcttactgaa tttcaaatat tacaagtttc atggcatatg aaaatacaag tt
#tgaggagg  33060
gagctatttt ataaatgtaa gacacgcata agttgcagcc actatgagat ta
#aacacatt  33120
caaaattcaa ataaggtaaa agtagcattt tttagtatat taataagtta tc
#attgcaat  33180
ttgaattttc actacctact cactacaacc ttgaataaat cacccattgc tt
#ctatgtct  33240
agataccttt ttatgcagaa ttactatttt aaaagcaact tatattagaa at
#ataataaa  33300
tattattcca tatgaattgc aataatgaaa tctatactta ttaaaagata ca
#ttaaaaat  33360
taatagccca agccaggcat ggtggctcat gcctgtaatc ccagcacttt gg
#ggaggccg  33420
aggcaaggtg gatcacttga agtcaggagt tcgagatcag cctggccagc at
#ggcaaaac  33480
cccgtctcta ctaaaaatac aaaagttann nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  33540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  33600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  33660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  33720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng at
#ctcactct  33780
gtcacacagg ctggatatgc agtggcacca tcacagctca ctgcagcttt aa
#ccttttgg  33840
gctcaagcga tcatcctgcc tcagtctccc gagtagctgg gactacaggc ac
#atgccacc  33900
acacctggct aatttttaaa atttttattg agacaagatc tcactatgtt gc
#ctaggctg  33960
gtctcaaacc actgaactca atcaatcctc ctgccttggc ctcacaaaat gc
#tgcgatta  34020
caggcatgag acactgtgac tggcctactt taatattttt taaaaatcaa ga
#tcacattt  34080
tgtaattttt aaacacacta cattaatgat atttgttgtg catgagaggt ct
#agcatttt  34140
taaactttgg acttgaaatt taaagcaaaa tttgtattta ggttgttatc aa
#agaaatgg  34200
ttaactgtgt aaaacatgtt aaaagttgtg tgtgcacctt aaaagctaaa ta
#ggatgcca  34260
tactcagaag cactattagg aactttgact gcagattaaa caggtaccaa ac
#aatagttg  34320
aaagtagttg gtgacatact tgggctaatc attgctaagg cttcctttct aa
#tatggatg  34380
tatgagaaat atagtaaagc ccatgattgt ttttctatta aaaatctaca tt
#tacaaaat  34440
attatctaga aagtatgagt gtctagtact tttaatttct atatacatgc at
#aacctgtg  34500
acttgttttg agtattattt gtacattttt atgggaaagc tttttcatgc tt
#ttaatatt  34560
ttctacttat gggaaatgta tatgcagtga catgtacaga acttgtgtac aa
#ttcaatga  34620
gttttgacaa gggcatacac ccatggaacc accattcatn nnnnnnnnnn nn
#nnnnnnnn  34680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnna tatattttat tgtaacttta at
#tcacattt  34740
ttctgatgat tcattatgtt ggatactttc atatgattat tggccattca ta
#tacaggca  34800
gtctttgctt tacatagtag tataggacta aaaaatgatt atagaaactg aa
#tttgtgca  34860
aagtaatcct aataatcaat gtagaaaatt atgattgttc tgtgaccttc aa
#aaattttg  34920
ttacaatatt caaaacttca agtgtcaatt ataaatgtat gtgaaaacaa aa
#aattattt  34980
agtatactaa tttaaaacat tagaaacata gagatttttt tgtataaaaa ct
#tatcaaga  35040
attttttttc tcattgttca gcttatgtta cagagagggc ctcttttcta tg
#tttcagtt  35100
aattgttata cactttcaaa gtttagatca gttttcaata ttttatcctt tg
#cactttca  35160
atattgtcaa atatcagcaa gagttctctt ggtgtgaaat ttttgttttg ct
#gtttttta  35220
cttccttcaa gacatcatcc ttcattgaat tcatcagaac cacttgcttt aa
#tttctgtc  35280
catatttgtc ttcagtaagt tgtcttggct gcatatgtaa agtttcttga ac
#agcagtgt  35340
taacattccc atggtcagct ctttgttctg aaactccgtt tatgttatat tc
#aaatttca  35400
tttccagcac tctcactttt gttgctctgc taccatcttt gttagccaat at
#gtgtcaca  35460
cgagttcatt gctgtgagac aaggaggcaa cataactaca caattttctc cc
#tgtgcata  35520
aactgaagaa caaatgcaca atgaccaatc aatgacagat tttgaacaaa gt
#gatgtcac  35580
tgattataat gtgcatctgt tatttatgta atgattttat ggatgaaaga gc
#tagaagca  35640
aagttttcat attataaaat ttttcatacc caatatatga tagtaacaaa tt
#caaactct  35700
gttttgagaa gacaggtgtt acttaactaa accatagtaa caaaaattca ag
#cacattgg  35760
aatgtgcaaa ggactgactt atctccttta gggaagtttc tgttcaagtc at
#tactgcat  35820
ttttctcctg aattgtctgt ctttttagta ctgagttata ggagttcttt at
#acattttg  35880
gatacaattn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  35940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  36960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  37920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt gtataaggtg taaggaaggg gt
#ccagtttc  37980
agttttctgc atatggctag ccagttttcc caacaccatt tattaaatag gg
#aatcattt  38040
ccccattgct tgtttctgtc atttttgtca aagatcagat ggttttagat gt
#gtggcttt  38100
atttctgagg cctctgttct gttccattgg tctatatatc tgtttggtac ca
#gtaccatg  38160
ctgttttggt tactgtagcc ttgtaatata gtttgaagcc aggtaccatg at
#gcctccag  38220
ctttgttctt tttgctaagg attgtctttg ctatgtgctc ttttttggtt cc
#atatgaaa  38280
tttaaagtgg tttttttcta attctgtgaa gaaagtcaat ggtagcttca ag
#ggggatag  38340
cactgaatct ataaattatg gagtctcact ctgtcaccca ggctggggtg ca
#atggcatg  38400
atcttggctc actgcaacct ctgcctcccg ggttcaagtg attctcctgc ct
#cagcctcc  38460
tgagtagctg ggattacagg catgtgccac ctggctaatt tttatatttt ta
#gtagagac  38520
agggtttcac cctgttggtc aggctggtct cgaactgctg acctcatgat ct
#accagcct  38580
tggactccca aagtacctgg attacaggtg tgagccacca cacccagcct ac
#aattcttt  38640
attagagata tgtataacaa atattatgtt ccagtcaata gcttgacttt ct
#gttttctt  38700
aatggcacct gtgcataatc agacgagttt aattttgatg aaatctaaat ta
#gcaacttt  38760
taatctcatg tcagtacatt ttgtgtccta attaaatatt gtgaaaataa ta
#tcctgggt  38820
tttattctag aaatgttata gttttaactt atacatttat atttttgatt ca
#tcttgaat  38880
tttgggtgtg tagtatgaga agtgattcaa agtttttttt tgtacattta tc
#aaaacatt  38940
taataactat tttaaagata cttttattta taataaataa acataggtca ta
#ataaattg  39000
atataggtca atcacttgac cctatgtgct tgaatttatt tctggaatat at
#tttattcc  39060
attgatttat ttatctgtta ttgtaataaa accacactgt gttgataact gt
#agctttat  39120
tataagtctt gaaatcagtt tgtgtaagtt ctacaaatgt gttctttttt ca
#aaattctt  39180
ctggctattt ttggtctttg catgtccata taaactttta aattataatg at
#cttattaa  39240
tttttacaaa aatgcccatg gcattttcat tgggattgca tcagatctat at
#acatgcat  39300
gtatacatct atacatgggg agaattgaca tctcagcaat gagttactaa tg
#aatatgtt  39360
attatttctc catttttaaa attatttatt tcagtaatgt tttgtggttt ta
#agtaaatg  39420
gattttgcat atcttttgtt aaaattattt gcatgtattt aattttttaa tg
#ttattcta  39480
aatagaattg attttagtca ttagtttgat gcaaaataca gaaacacaat ca
#atttttat  39540
attgacattg tatcctatga cattgttaaa tttacttctt agttctggaa tg
#ttaaaaaa  39600
atttaaataa tattctatat taaaattatt gtgtcttcta aaattaaaag ta
#tttttctc  39660
tctttctttc tttcttaact ccatgacttt attgtttgtt tgttttgcct ta
#tagcactg  39720
gcttgactct ccagtacagt gttaaacaga ggtgataaaa gccaatatcc tt
#gtgttgtt  39780
cccaatttca gggagaagga ttagtttttc atcattttat atgatattgg ct
#gtagactt  39840
tctgtagata ccccttatta aattgaagaa gattctttca tttatagttt gc
#tatgagta  39900
tttattgtga atggatgtta aattttgcca cttgattctg aatttaaggc aa
#taatttgc  39960
tttttctctt ttattctctt gctgtgataa gttacatggt ttatttttga at
#gttaaatt  40020
atatttacat tcctgggata aaacacactt gatcagatgt gttattctac ta
#tatattgc  40080
tggatttgat ttagtaacat tttgcttaag attgttgtat ttttgttcag ga
#taggtatt  40140
ggtctataat tttcttttat tataacattt tttctcagat atttacatca aa
#gttatact  40200
accctaatat cagtagttgg ggaatgttct ttcctccttt attttcacag tt
#attatttc  40260
atcctaaact atttgataga attcactagt gaaaccatct gaacctggag tt
#ttctattg  40320
tggcagattt tgtattactt tgacttcttt aataaatata gaactactca ta
#ctttcttt  40380
ttaaaaaatt ttactttagg gccgggcgcg gtggctcacg cctgtaatcc ca
#gctctttg  40440
ggaggccaag gcaggcggat cacgaggtca gtagatcgag accttcctgg ct
#aacacagt  40500
gaaaccccgt ctctactaaa aatagaaaaa attagccggg catggtggcg gg
#cgcctgta  40560
gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg aacccgggag gt
#ggagcttg  40620
cagtgagccg agatcatgcc actgcactcc agcctgggcc acagagtgag ac
#tccgtctt  40680
aaaaaaaaaa aaaattattt taagttctgg gatacatgta cagaatgtgc ag
#gtttgtta  40740
cacaggtata catgtgccat ggtggtttgc tgtacctatt aacccatcag aa
#tttctata  40800
tcattttata tgttatgttt ccaagaaact tgaccatttt atttaaaatg tt
#gaaaatat  40860
tggctcaagg ttttttgtaa tctgcagtga tattcctgat tttattcatg at
#gtgaattg  40920
tgtttacttt ctttttatac atcttaataa gtgtttatga aatttataaa tt
#tttccaaa  40980
taaccaactt ttatattaat taatgttctc tattgttttt gtgctttcca tt
#acatcgat  41040
ttctgatcat tatgattttc ttgcttctaa atattttgcc ataaggttct at
#gtattagt  41100
tccatgtggt taatagtgtt ttgcaaaatg tctgtatcat tatcactttt cc
#gcctaatc  41160
gttctaacag ttattgagaa ggaaatgata aaatatttaa ctacgattgt gg
#gttttttt  41220
ctttcagttc tgtccaggtt tgcttcatgt agtttcagtt aaaaaaaaag tt
#tttaccaa  41280
aaacatgcgt attgtgattg ttatattttc ctaattaact gatcctttga tc
#attataaa  41340
ctatcccttt tatctttggg gacacttctt gtattaaggc ttttttgtct gt
#tattaata  41400
taacacatgt tcttttattc gtggtttgca tcatatatct ttttctattc tt
#acttgtga  41460
attatttgta ttgtatttaa actgtggctg gtggacaaca aagtacgtct ct
#tgtgaaca  41520
acctataatc aggtctttaa tcttgtctga caacctctga cttttaaatg ga
#gtatttac  41580
ttcatttaga tttaaactta gtattaattt acttgacttt ggatgtacta tt
#ttttcttt  41640
gttttctata tgtcctatct catttttagt tcctctgttc ttgctttctt tc
#ttgccttc  41700
tactgggtta actatatatt tttagcatta tattttaatt cttctatttg ac
#ttttagct  41760
atgtttcttt gtattattat ttttcgtggc ttctcaaggg actgcaatat ga
#atacttga  41820
cttatatcta cttaatttat gtaactggaa ataaaataca tgaattttgc ag
#aagtattc  41880
ccatgtactt ccctgtagtt tctgctgtta ttgttatatt ttttgtactt ac
#ttttatag  41940
atgtcaggtt gttatacgtg tcagctatat atattaatat acgtgtgtat gt
#gtgcatgc  42000
acactcggtt tttcagctgt ctttctactg agctccttgg attctccgtc at
#gtacatat  42060
aattaaaata ttaggcaagg atttaagggg agtttagtcc caaactttgg at
#ctaactcc  42120
tctgtttcca actactttag cagcctcata ctttattctc tgacacctca ag
#ccaatagc  42180
tgcgtttttt ttccttttcc aagttcatac atgttatctg cagaatagtt tg
#atataagt  42240
tatcaccaga tcagagttcc tcaagttgga atattttgtt ttaaattctt ag
#ctgctttt  42300
gcaaaatttt tgcccaaaat atgaatctga gctcctttca aggtttttat ta
#aaatatct  42360
agtcacactg aacactttag tgtataatag ccttaatgtc acttggtgat gg
#gtagatag  42420
aagaggagtt tacattgcaa taatatatat ggctttaaat tgattattag ac
#atttttgt  42480
tctaaaaatc ttttgatcca agtgtggtgg ctcacacctg taatcacaga gc
#tttggaag  42540
gctgaggtgg gaggatcttt tgagcctagg agtttgagaa cagccttggc aa
#tgtagcga  42600
gatcccgtta gtacaaaaaa aaaaattagc ctagagtggt ggtgtgtgcc tg
#tagttcca  42660
cctactcagg aggctgaggt ggaggattgc ttaagcccag atgtttaagg tt
#acactgag  42720
ctatgaaggt accactgcac tccagcctgg gcaacaaaat ggcaccctca tc
#cctgtaat  42780
cccagcactt tgggaggcca gggtgggcag atctccaggt caggatttcg ag
#accagcct  42840
ggccaacatg gtgaaaccct gtctctacta aaaatacaaa attagtcagg tg
#tggtggca  42900
catgcctgta atcccagctg ctcaggaggg tgaggtggga caattggttg aa
#atcaggag  42960
gcagaggttg cagtgagcca agatcatgcc attgcactcc agcctgggca ac
#aagagcga  43020
aaccccatct caaaaaaaaa aaaaaaaaag aaaaaagaaa aagaaaaaga aa
#agaaaatc  43080
ttttggcaat cagagagttt tctgttggtt gctttatacc actgaggccc at
#gtccccaa  43140
cctcacacca tcctttgagc ctttgttctc attgtttctc cttccatctc tt
#ccttctct  43200
ctcgctttct catatgggct cctgaacaat cccaattctt tctttattct tt
#cttatgga  43260
tattttccca aagcttacag tcagaactcc ttgtgtatat tttaatcaat aa
#agtttnnn  43320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  43380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  43440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  43500
nnnnnnnnnn nnnnnnnnnn nntatttttg aaatctgtcc atccatccat tc
#atctatcc  43560
gtctgttgat ttgttcactg attcacattt ttgctaagca agtacttatt aa
#atatcaat  43620
gtgtgccagg cattatatgc ttatctgttt cttctgacct tttttttttt cc
#tattctac  43680
ttcactgtac attaactatt gatatagact caattcttca tctctggtgt tt
#tgataata  43740
tgagtactcc tttcaaatgt tcatttactc tcatgatttc aattacttat ag
#atacagga  43800
attctcccaa attcctttac gtgacccatt atgctaacac aaacctctcc tg
#tgataact  43860
ctgtttatcc tgctaacaag atatgaagct aacattttat ttcctcatac tc
#attcttgg  43920
gtaaatctcc acaagccagt atgtctttct aatttcttcg tcactctcaa tg
#gttcaatt  43980
tagtctccag gtgttatagg agtggtctca atagataatt aagttggctt tc
#taattagt  44040
cttctaagaa ctgtttcaga taaactatgt aaaatcaaag ttgtcatttt tg
#ataaatat  44100
tctcatgaga tgacttactg catgcagctg tcaaaactaa tgaatttata aa
#tcaagcca  44160
gctcattttg cctttgtatt agtctgttct cacactgcta tgaagaaata gc
#taagactg  44220
ggcaatttat aatggaaaga agtttaagtg actcacagtt cagcatgact gg
#ggaggcct  44280
caggaaactt acagtcatgg caaaaaggga accaaacacc tccttcttca ca
#tggcagca  44340
gcaaggaaaa gtatgagtgc ccattgaagg ggcgagcccc ttataaaact at
#cagatctt  44400
gtgagaccta actcactatc atgagaacag gatgggggaa accacaccca tg
#attcaatt  44460
atctcttcct ggtccctccc atgacatatg gggattatgg gaactacaat tc
#aagatgag  44520
atttgggtgg ggacacagcc aaaccatatt ggcctccaaa cagaatatgt at
#aactatat  44580
gtataactag ctttccttgt aacgatccct aaaaaatgac tttttctttg ga
#agttttat  44640
tgagaaattt tttaaaggta agtgtttcac agtatgtaat tttaagacta aa
#attatagc  44700
catggtttat atttggggcc ccaattgtcc aactatacat gcatgggaac ag
#atacaaaa  44760
caattttaaa atatcttact cctatttcat gcacattgaa tacatttata ag
#actaattt  44820
ggcacattag tatgaatggg tcagtccata ttctcagctt tgtagtagca ct
#caaaatcc  44880
tgtttgtgtt tcataacttg ataaatactc caaaatttct ctggattaag cc
#aggctacc  44940
agagagagtt gcacatgaac ggtatactta caatctctga agacatagtt tt
#aataaaac  45000
atatttgaga attattccac ctacgtactc agagtgacgt tgtaagaatg gg
#aaattttt  45060
ttttttggat ttttttaatt tttatttttt attatacttt aagttttagg gt
#acatgtgc  45120
acaacgtgca ggtttgttac atatgtatac atgtgccatg ttggtgtgct gc
#acccatta  45180
acttgtcatt tagcattagg tatatctcct aatgctatcc ctcccccctc cc
#cccacccc  45240
acaacaggcc ccggtgtgtg acgttccgct tcctgtgtcc atgtgttctc at
#tgttcagt  45300
tcccacctat gagtgagaac atggggtgtt tggtttttaa aataaatttt tt
#ttcccatc  45360
ccaaaaaatc agaatgggaa aaaattttta tttttattta tttatttatt tt
#ttatgaga  45420
tggagtctca ctctgtcgcc cgggctggag tgcagtggcg cgatctgggc tc
#actgcaag  45480
ctccgcctcc cgggttcatg ccattctcct gcctcagcct cctgagtagc tg
#gggctgca  45540
ggcgcctgcc actacgcccg gctaattttt tgttgtattt ttagtagaga cg
#aggttcca  45600
ccgtgttagc caggatggtc tggatctcgt gacctcgtga tccgcccgcc tt
#ggcctccc  45660
aaagtgctgg gattacaggc ctgagccacc gcacccggcc aagaatggga aa
#aattaaac  45720
atacttagta tttactgtgt atggatgttg tcgaggacat tgcttattaa at
#tatggtac  45780
cctctttatg ggttttttca gaagaaatgt atctttggtt tcagtatcag ag
#attattgt  45840
atttttgttc atttaattta tctttatttg cgataacaaa gatttactat ct
#tgcttttc  45900
cctttatttt atttatttgt tataaagagc caaatttata atttacttct ag
#gaagtcta  45960
cagtgtgtat tttgtcagtt aatctaattc ctgggttcat tccatttgtt tt
#acccctat  46020
tttctctgtg ctcaatatac catcacatcc tgtcaatatt tctttacatt tt
#tctttagc  46080
tctactccta attattttta acctaccaga tcattgtaat ctatgttgtg ct
#ttatatgt  46140
aaaatatcga acaagttttt atcaaacttg cctattccta ataacaagtg at
#atgaaggc  46200
tcagactttt aagtttatat gtcactaatt aatctctgtc tgttgtttct ct
#gtcaccta  46260
ctgtagtcac ctaaactgct ttcaaacttt cactgccttt caataacacc aa
#acctgata  46320
atcccccaca cttttttctt atgactgcct tacactattt tccttcagcc ta
#agattttt  46380
cccagccctt gacaaacatt ttgttgccac ttatgtatct ctccccgtac tc
#aacccact  46440
gaatcctttt tctttcacat ctttactaat cctcagttgt tccttcaaat ta
#gagctccc  46500
agatcttctt ctctgtcctg ttgcatttac ctctttgtag ttatttctat ta
#actaaaat  46560
atttttcatc tatgtatgaa aaggttctta tacattgact tgtatcctgc cc
#acatcatt  46620
caatgtgaat gttcaataaa tgctattgat taaattcaag ctagtgcaaa at
#ttgtagct  46680
ggtatgctga aatatgcttt gaacttaact ttgaaggtat ttccattttt gt
#attgatcc  46740
atactatatt aatgttagca aattttactt tgtgtatgtt taaattatct at
#ctgtatgt  46800
tgtgtttcta aaaggatagt agattattta aaatttctag agacaaaaat at
#tcttaaac  46860
ttgggaagat tgggttgata attttgtatg ttttataaat ataattcaca aa
#tataactt  46920
ttcagacatc tgttttgctt aaaagagagt acatctgttc ctgaaaaata aa
#aatatata  46980
gtcataaata aacaatttaa acttggtcat ccaacttagt gtacttatcc ag
#gtcaatga  47040
gaagtcaata caaaactacc ttcacaatcc tatcaggaga gtttggcaat tt
#ctaataac  47100
tgatattcag aagtttatag aataattaca ttttatacat gtattcatct tc
#taagtaga  47160
atttactggt cagtaaaaac tctcatgcat ttaaacctat aacaaattct tg
#cttattta  47220
gatctacaga ccctaatttc aaccatgatg aaagtatttt agtgataaga at
#aatttatg  47280
aataaaaatg taatttagtg aataccttgg cagttaatgt tgatcgcttc at
#cacagttc  47340
agtcatgttt agaaaatcta agcaagctgt gtgattactc caggaagcat gg
#aatgatgt  47400
gttcaaatta gtaccatctg tggatagaaa aagtttgagg tttttagtca tt
#cttaaaga  47460
atggaaatct gattctccat gctgaaatga gtgtaatcct ttttctatct gt
#aattcaat  47520
agggcagttg ccttgaaata gtctagttca gcacacagtt catcaaagag aa
#gatactgg  47580
atataaatga gggttactgc tggtcactta tgaatacttc tgaggtagcc tt
#gtttaaaa  47640
aattgtctac aagttatacc atatatttca cctcagatca gattcatttt tg
#gtttatct  47700
ttctaaatac atttgagtga aaatgtggac tagattttgt accacatgaa aa
#caaaaggc  47760
tgtttcaatg aaccatcatt tatttccaca gtcaacaaac acttatgagt gc
#cagtatgt  47820
tccagtgtcc catcactgtg cctgtcacat aataggaggc tgaaattgtc at
#tatgtttc  47880
ctatagccag gttacaaata actcttgcct ggatttagtg gtttttcttt tt
#aagacctt  47940
ttcttctctg aaagcttaat tggagaatac tagagtctgt gaacgaatat tg
#atctgctg  48000
aaaattttta ctgtgtagca aaatttgcta gtaacaaaca ccagctatcc ta
#aaatctga  48060
acattggagg aaaaaatagt tgatcataga ggcatgggca tctagtcatc cc
#tccagatg  48120
ggattagcaa agggcagcct cttctgcctt ctctagttca ttagctagtg aa
#tatttccc  48180
tctcatttcc agtggtttag caaactctag ggagagaaaa ttgaaacatg gg
#aaaggtaa  48240
ctggtagtag atctaaaaaa gaataaataa aagaaggaaa gcatttgtac ac
#tgattctt  48300
atgaggaaag agtagagtgt aagattttaa tgaaaacaaa agtcaatata aa
#aattttca  48360
aggccaggtg ccatggcgca tgcttgtgat cctagcactt tgggaggctg ag
#gtgggcag  48420
atcagttgag cccaggagtt caagaccagc ctgggtaaca tggcgcaact cc
#atctctac  48480
aaaaagtacg aaattagttg ggtgtgatgg cacacgcctg tgattccagc ta
#cccgagag  48540
actgggttgg gagggtcata tgagcctggg aggttgaggc tgcaatgagc ca
#tgattgtg  48600
ccactgcatt ccagcctcag caacagagta agactctgtc tcaagaaaaa aa
#aagtaaaa  48660
atttccacat aataaaaacg atcatcagca aaataaaaag acaaataaca ga
#tttggaaa  48720
atatatcttc atcaaggatc acaaaaaggt tatattaaag gcttaaataa at
#aaatagca  48780
aagccataca cccaatagaa aaaaaagtag aaaaaataca aatgatagtt ta
#tgaaaaag  48840
gaaattaaag agagagaagt gcaataagct tcacactgaa acagaatttt tt
#ccctctga  48900
aacttttatt gcatactctg ttggcttggg gaacaggcat tctcatgcat gt
#tgacagga  48960
gtaggtattg gtaaaacctt tctggagtgt gatttagcaa tgtctaccaa tg
#ctacaaat  49020
atgcatatgt tttacctagc aacgattatc ctacagattt actcacacat at
#gtgtggaa  49080
tatgaaagca taggcttgta cattacagct tgtttactgc aaatattgga ca
#cagcttaa  49140
tatcatttca tagaggctgg taaaatcaaa ttcgatatat ccatttcaat gt
#gcttactc  49200
catacaactc caaacactga agaaaaaggc aaaatatatc caaagcatat at
#atagtgac  49260
cctaaatccc agtttccagg gcagtctggg tttatgcttg ctgtgctggc at
#ttcatcca  49320
atagacattg ccttttactc tcaaaagtga cctgtctgta taacaaataa tt
#tgctgcaa  49380
tggagtgaat gtttatttcc cccctagaat catatgttgt agtcctaact cc
#ctgtgtga  49440
tgctattaga aggtgaggcc tttcagaggt aattaggtca ttagggtaga ac
#cctccatg  49500
aatgggatta atgcccttat aaaaagaatg cagagagctc ttttgccctc tt
#tctgctat  49560
acaaggacac aataagaagc cagcagtctg gaaccaggag gctggttctc ac
#cagaaacc  49620
tgccatgctg gcaccctcat ctgactttca gttccagaac gttgagaaat aa
#atttctgt  49680
tgtttgtaaa tcactcagtc tatagtaact tgctacagca gccaaactaa ga
#cagtcact  49740
ctagatatat tctttggaag tgagagaagg gactgggagg aagaagagag tc
#ggatatga  49800
ggttagatga aaagaaaggg aaggctgcac tccagcctgt gcaacagagt ga
#gaccttgt  49860
caaaacaaaa caaaaacaaa aacaaaaaca aaacaaaaaa aacttttcaa gt
#atatcact  49920
gtgcttcaga taaagctaaa agtcatatat ttggtttaag gactcagttt aa
#tgtgattc  49980
cacttacatt gcctacttcg ccccttccca ttcatctcct tgtagaccca gc
#agccttca  50040
ttaagtgttt tcaatgtgtg acactcttct tcttcagggt cttaacacct tc
#acacatcc  50100
tgatattttt tatctgtgaa gcttcttctt atccttcagg tctctaatta aa
#ttatcctt  50160
caccaggaaa gccaaataaa gtcccctgtt ataccctcga ttcatttgct ca
#cacattca  50220
aaaaacattt attgaatcac cattttgttt cattcagtag tctagactct ga
#gagagaaa  50280
atctgttatg tacattgaca ttttatgtgt ttataaccta caaataaaca tc
#tatttttg  50340
agtgattttt ttcaatattt ttattgagat ggatgcggaa gcaaaatctt tt
#tgaatctt  50400
ttatatataa tgttggggtg atgtggaggt gaaagtagat taggcctctt tg
#gagtgggt  50460
tttcagtgca gagctgagat ttataggaaa gtaaatatca gttcaaaata at
#gcaggcta  50520
tacaaactaa tagagctatc tgaaaatgaa ttttaaaata aactaccctt ga
#gatgttga  50580
gtttcccttg ctctatgtat gtaagcagag gctgggtaag tagtgattgc tc
#attttgta  50640
gggggaggtt tgtattggtc ttctattgct gtgtaacaaa ttatcacaaa ct
#tagtggct  50700
taaaacaata cccatttatt agctcatagt tctataggtc agaagtccag gc
#gtgttgtg  50760
cctaggtttt ctacttattc tcacaagctg aagtcaactt gtcagtcaac at
#tttcttgt  50820
gtaactcagg gtcctctttc aggttcacgt ggttgtggta gaatttagtt cc
#ttgcagtc  50880
acaggattga gagccccttc cctggctggc ttttagctaa gggcttctct ca
#gctcccaa  50940
agatgttctg tgttccttat catgcagctc cctccttctt gagagccaac aa
#tagagaaa  51000
tttttgtacg ttgaatccat ctctttaaag ctttgacttc cttttctgaa aa
#cggccaaa  51060
aatactatcc tccttttaga gggctcaggt tataaggtca ggtccactgg at
#agctctct  51120
attttaaagt aaactgatta agattcttag ttacagcagc aacatagctt tc
#catctgta  51180
cctagatcag tgtttggttg agtaagtgga agaatctgtt tttgtacagg ga
#ccgggaat  51240
cttgagggat atctgcagac acaaaggtca gacaaagaga caagatgacc aa
#gatgatct  51300
ctcaatttca aattctgaga ttacgtgatt tttctcattt atttgcctgt tc
#ttatggat  51360
tcagtcgcca aaatatatct taaaaactga cttctgtact gttgctatca cc
#taatttcg  51420
tctttcctgg acaaatcaag tagtctctga atttctccct tttcctgttt tg
#caattacc  51480
agactgtagt tgataaaatg tacctctgga catactgtga cattttttat ag
#ctttcaat  51540
tgcctgacaa gctatctata gtttcctctg acacagtaag tccccaagct at
#tgtgcagt  51600
cttgctgttt gttattgccg acatgaatta caagctgcaa ttaaacttgt ct
#tagctcac  51660
atcaccctct cttccatgat ctccactttt acaatcagtg aaattccatc tc
#atgtgcca  51720
tctcttctct aaaaacattt tctgaacacc cacgtcaatc aaatacatct ga
#tttatatt  51780
agaatatttt gaaaatgtat cttatgttca gatgatctga gttcaaattt ag
#tgactgag  51840
gcatttgaaa aaattatgaa aattctaaaa cttcttcctc tataaattta ca
#tttttttt  51900
ccctaaagat agtgttttct ctaattgctt ttcttcatga taggtaaaga ta
#aaacagaa  51960
tgtgttgtaa atagtgtgcc agttttggta aatatatata tatatatagt aa
#ataagcaa  52020
tagatctgta aataattcga taaaaattta agatgaaatc caaaatttta ac
#tgaagtcc  52080
agacctctct ctacagaatc cagactcaag cttctatcta gtatttgatt tc
#tccttctg  52140
ggtgtctgag aggaatttca aagttaacct actcaaaaga aattgttaat ct
#tcctcccc  52200
aaagcttacc cctcttacgg tcacccacat cttgattaat agtgacttca tc
#tttttatt  52260
tgctcaatcc ataaacctta gggcattttt tattcctctc tttctctgat at
#ttcacata  52320
ccacacatca gcaaaccctg ccagctctcc ttcacattat attcaggagc tg
#aatgtttc  52380
tcttcacttc tgccactacc accttggacc aggccactgt gatctcttgt gt
#tgacattg  52440
cagttgcctg ctaattactc tccagccttg ttacccttta gtctgttctc aa
#cacagtag  52500
ctagagtgat tctgtgaaag agagagcctg ccacttctct gctcaaatga aa
#gccatgac  52560
aatgtcctct agtgtcatgt actggtagct tgtaccagtc actcagtcct tc
#ttgttatt  52620
ctccaaatat accaggcatg cctccaacta tacagtttcc tctgcttcaa at
#ttctcttt  52680
ctgaaatatt gacatggcta ggtcccctac ctacatatgg aatttagtat ct
#tctttttc  52740
tttttttttt tattattata ctttaagttt tagggtacat gtgcacattg tg
#caggttag  52800
ttacatatgt atacatgtgc catgctggtg cgctgcaccc actaactcgt ca
#tctagcat  52860
taggtatatc tcccaatgct atccctcccc cctcccccca ccccacaaca gt
#ccccagag  52920
tgtgatgttc cccttcctgt gtccatgtga tctcattgtt caattcccac ct
#atgagtga  52980
gaatatgtgg tgtttggttt ttttgttctt gcgatagttt actgagaatg at
#gatttcca  53040
atttcaccca tgtccctaca aaggacatga actcatcatt ttttatggat gc
#atagtatt  53100
ccatggtgta tatgtgccac attttcttaa tccagtctat cattgttgga ca
#tttgggtt  53160
ggttccaagt ctttgctatc gtgaataatg ccgcaataaa cacacaagaa aa
#aaacaaac  53220
aacccccatc aaaaagtggg cgaaggacat gaacagacac ttctcaaaag aa
#gacattta  53280
tgcagccaaa agacacatga aaaaatgctc atcatcactg gccatcagag aa
#atgcaaat  53340
caaaaccaca atgagatacc atctcacacc agttagaatg gcaatcatta aa
#aagtcagg  53400
aaacaacagg tgctggagag gatgtggaga aataggaaca cttttacact gt
#tggtggga  53460
ctgtaaacta gttcaaccat tgtggaagtc agtgtggcga ttcctcaggg at
#ctagaact  53520
ggaaatacca tttgacccag ccatcccatt actgggtata tacccaaagg ac
#tataaatc  53580
atgctgctat aaaggaattt agtatcttct aatcccttct ctgattacct aa
#tttaaatt  53640
ttcaatatcc ctgaaactct ccttcttctc attcttcttt ttctccgcaa ct
#ctgatcat  53700
catccaaaac actacagttg gccctccaaa tccatgtgtt ctgcatccgt gg
#attcaatc  53760
aactacagct ggaaaatata caaaaccaaa atgtgtctgt accccacatg cc
#cagacttt  53820
tatttcttgg cattaatctc taaacagtac aacagctatt tatagagcat tt
#acattgtg  53880
ttaggtattg taaataacct agagattatt tgaattatat gagaagatgt gt
#gtagttta  53940
tatgcagata ctacaccatt ttatataagg aatttgaacg tcttctgatt tt
#gttctccg  54000
tggaaggtct gggagccagt accctgtgga tacaaaaggt gactatgtac aa
#tacttatt  54060
gatactttta ttgtttacag ctcccctgaa tgtaaatttt caggggcagg aa
#tttttgtc  54120
tgttttgttc attgtatttt cagcacctat aatcctacct gtacatatta ga
#tgctctta  54180
gatatttatt gaatgttgaa ttaatatatc tttagagatc aatgagcttt ct
#aaatattt  54240
attaattttc ttattttaaa atgtgaatat taatatacag ttcgcattat gt
#aattttca  54300
catgtcatca ttttgattct ctttatctcc atcttcttaa caaaggccgt tg
#aagatata  54360
caaagaaagg catggttaag aagagttcca atatcactta attgattgct ct
#ttcttatt  54420
tctaaccata acatgtgtat attacttgcc caataaactg tctcttgaaa ac
#aggacatg  54480
agctttattg tatcctgaat ccctaacacc aggctcagag cctgacacat gg
#tatgcatt  54540
tggcaaacct gtagttagtg tggaagcaaa taaatgactc caagcaggac ta
#catgttaa  54600
ttctaaatat acatgagata aaataaaaaa aaatagatga attatataca tt
#aaaactgt  54660
cagtaatatt gtttatttaa aattgtttta taatcaacat ttannnnnnn nn
#nnnnnnnn  54720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnntaatgcc cttgacccag gc
#ccacattt  54780
ttccttcata tttagaggtt ctgttgcttt taagcccaac tttacaacct tt
#tcagtgac  54840
ttcaaactta cacacacaca cgtgtgacca caataaccct gattgatctg tc
#tgcaagtc  54900
gtttttcagc ttgtgttttt caactgcaca aaattctgag gcaaagaaat at
#caagcatt  54960
caactcccag cttgagatgg gaagaagaaa atacagagaa gaaacacaaa ta
#cttgaaat  55020
tgttttgcca tctatacatc tttcaggact ttaagtgctt ttccatacaa ac
#cactaaat  55080
gtataggtaa agattgctct tgcaacttag gttttatgtt tatagctaac tg
#gttgccct  55140
gcttgcttgg agaatatcat taaccataat taagtaaaaa atgtatattc ct
#tatcctga  55200
actctgttta catagaattg tgatggttac tatgcaacat aaataagttg ca
#aatcaagt  55260
cctgcaagcc agagctctgg gaaatggctg cattctctga aatgccattt ct
#gccccagc  55320
cctccagagc aaatttcagg tttgccaggc cacccatccc atataaatcc tt
#cagatata  55380
ggccttatgt tatcatcttc ctatcttgac tgagactctt taaaggggat tc
#ctttcaaa  55440
tccaaattac atattcttaa acatttttga tacttattag tatagtaaca ta
#cctacaca  55500
cacacacata gattttcagt gacaaatacc atgttagtac ttatagatag tg
#aaatacac  55560
tttgatctag agggctttat tttctaggcc accaattgtg tctcctgtta ca
#atttccca  55620
gagtatctgg cataatgtct gtaatagtaa atgttcaata aatgtttgtt aa
#tataattt  55680
gacatttgag gtagaatcct gacaactcag actttgacac aattgtccaa cc
#ttttctct  55740
ttctggcact ttgacacttg gtttctgtaa gatctaccct tctgtttttt ct
#cctacctt  55800
cctggtagct ccgtctccgt cctctttgct gaattattct cagcaaataa tt
#gtttttta  55860
actgtaagca ttggagagat gagagagctg tacttggccc ttttctcttc tt
#tatcagca  55920
cacaaccnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  55980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  56940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  57960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  58020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  58080
nnnnnnnnnn nnnnnnnnnn tgccgtggcc tcccacagtg ctgagatttc gg
#gcatgagc  58140
taccatccca cgcatatttt cttattgtct agaatagttc ccagtaccag ta
#gatactct  58200
ataaatattc cctgaatgac agaaatttga ttcattaagt tctagtgggt ag
#gacaaaac  58260
agattgtttt ccagtgcagg tgatgataag gatgacgata ctataacaaa ga
#tagcaaaa  58320
atatagaaaa aattcagttt actttggggt tagtcagtag gtatggttat tt
#tgaacctg  58380
ctgattttgt caagaaatag ctattctaat ataactagaa aacagaaata aa
#taaatgcc  58440
cagagaacaa aaccaaatac atcagtagcc tagatctggc ttgtggacag ct
#gatttgta  58500
acctttggtt aaattatgcc tgtgcctttg tgcctgctgc cactaagagt tc
#ctattctg  58560
agtatctcac ttggggagta cctgcttcta attgccacac tgagccagga ag
#tgaacttt  58620
ttaaatgcac agtctcttgc aagcacactt gacactatta tacaagatgt tt
#aattagca  58680
taaaacaaca tataacatga tcagttcaga agttggtaaa tgaaactgaa aa
#gttggatt  58740
tctaaataat cctacattct caagtctttc cacttgaata tcattctttc ca
#ccctattt  58800
cctccacttc ttaccccctt ttaagttcta tggccatatt ttatttccag ga
#gacacagg  58860
ggaaatggtc tttctaccac tgtgattagg agagaaagat gaaaagattt at
#atttttca  58920
acttcgtgat aacaaacata tgattgcatt ctcaaaactc atagcttttc aa
#ctaagtag  58980
tcataagtgg ttgaggataa ttctttaaat tttgacgatg agttggttac tc
#gtctttta  59040
gtttcaagaa tggaggaaat ttttgcttcc aatggaatag aagacatttt tc
#taatgata  59100
aatattgtac aattgaattt ccaaatttca taatttatac atcaaaataa aa
#gttctatt  59160
tattatatta agtcaggaag agataatttg agattatatg gggaactgca ta
#tattattg  59220
caacataata tatatggtga aataacataa gaataaaaga aattataaca gt
#taagtaac  59280
ggaagtcttg aagagcaata atccttttaa tattaaaaat aaggcattca ta
#gatgttgc  59340
ttctgcatac caaagatgaa aatataatgg ccatgttgca aactcaaaaa at
#aatttgga  59400
tgaagaatat taataagttt tgtattatgt ataattcact taaaaatgtg gc
#atgagtca  59460
tgtggtggct catgcctgta atcccagcac tttgggaggc tgatgcgggc gg
#atcatttg  59520
aggtcaggaa tttgaaatca gcctttccaa catggtgaaa ccctgtctct tc
#taaaaata  59580
caaaaaatta tccgaacatg gtggtgggca cctgtaatcc caactccttg gg
#aggctgag  59640
ggaggagaat tgcttggacc cgggaggtgg agcttgcaat gagccaagat tg
#tgccactg  59700
cactctagcc tgggttacaa agccagactc catctcaaaa ataaaataaa aa
#tgcaatat  59760
gttgtttcat gatataaaat aaaataataa ctctttctct gaattagaga aa
#agactaaa  59820
caacaatata aaatagtaca aaataactat ctcagagaac tgcattttat cc
#taatgaca  59880
taaagttgta ctcaagcact tactaatata acatcttgtc aaaacctgga tc
#ttctctat  59940
aaagagttat tgattaatgg gtagtttgaa atcaaattgt ttaaaatttg ag
#taactcca  60000
ataaaagacc acctagtttt aataataaat attataaaag tttctacaat gg
#attatata  60060
atcagaaaac atgttatcat taactatctg agcccataac aaagagcatc aa
#aattgaag  60120
atcaggaaga aaagtcagaa tgcaagctga gatttaaatt ggattaccct gt
#gaatctga  60180
gtgtacacct gtaaaacaga ataaataagg gaaacaatat tcaaccaact ca
#agctaacc  60240
attctttctc tcacatgctc tcacctagat cattgaagcc aaattgcttt tg
#ttctcaac  60300
taatccgtat aatagccata atcctactgc atgctgagag tgtatagata ca
#aatataag  60360
cataaaaatt ttaaaaaatg gcagaaatat ttaccttgaa acattacagt ca
#tgcaaatt  60420
attttactca tctatttttc tgattatcct taaagtcaaa agcagtttga gt
#ggtgtgtg  60480
tatatatgtg gtggtgatgt aaagtcacaa gctgttaaat gtttctgtgg tg
#cacaatag  60540
atacttatgc tgaggaaatg tacaacttta aaggagtgtg ggtgtgaaat ta
#gtatgaaa  60600
tggaatggga ctctcataat gtgcgtctcc tatagaccac caagactgga ag
#acagcaag  60660
aaaggaaaat tcctggggta acacttaggt tgggaaaacc acaggatacc at
#actcatga  60720
ggaattttaa ctacccaaac atctgttagg ttaaaaaaaa ttcaacaaaa ca
#tgcctcat  60780
caaagaagtt tctaaggaat gcaactttat gatctaaaaa gaagaaaacc aa
#atagaggg  60840
caaagtacac tttaacatta tttaaaatta aaaattgtca atgtgttact aa
#atatcagt  60900
tgttttcctt agttttttct aaactgtgta atacacttat gtgataagtg tt
#atagtaac  60960
agaggtagaa attatccttt ttataaagaa gcaattatat aatggtaaga ag
#tgatttta  61020
gccataagta aataggagtc tataattcaa gacatttaga agttcatttg gt
#ggcagtgc  61080
agtattagga tgggctccat cttgctgcca ctagagaaaa taaatatcat tt
#attctaga  61140
catgatggtt gcacttctgc aaaattagtt agatgctgtt gaaaatcttc ta
#aattagtt  61200
acacaggact ccctaatggg taattcaaga caacatttct gtcctctagg cc
#cgaatatt  61260
gaagttattg gtataaccac ttaggttccc atagacatct caaactccat at
#tgccacct  61320
tcccttgcaa gtcttttcct ttctgtgtgt tccgtgtctc agtttactgc ac
#cactattc  61380
atctagttgt tcaaactagt tatctagaaa tcattgttag ttctttttac ct
#actctcat  61440
cccccacgag gcaaaacctg agtcctattg tatttacctt ctaaatatct ct
#tgtatttg  61500
tttatttttc ttttcaagtg tctctaaatc cagactttta catttatctc tt
#agataatt  61560
acaaaagaga tctaaatggt ctttctgctc tcattttcta ccattcacct ga
#actcagca  61620
tttcaataca cctgcctgac catgaatttc ctctgctgaa aatctttgat ca
#ttttctac  61680
atgcctgcat gttaaaacta tgcccattag taagttctac aaggtcactt at
#gatttggt  61740
ttatatttct cacacatgca ctgttctttc tcctttatga tccagaatct tt
#gctattct  61800
ttcttattgt cctttctttc ctcctcttct ggtgaccagc tttgttttcg ct
#atgttttt  61860
aagtatctct tttgagaaac ctttcagaaa tccttatttc cagtcccacc tc
#ccaaaatt  61920
tgtttctcaa caagtgagca tattacatca tagttatttc tctctctttc tt
#tagtgggg  61980
ctttgagttc cttaaaagca taaatagcca gccgcgcatg tcttatgtac ct
#ttctgtcc  62040
cctgtgccta cttttaatct aagatttgtt atgaatatgg aagaaaggca tt
#tgacttta  62100
atgttaaagt gttacagtgt caaaattctc catattttaa aatagttcat gc
#tgatattt  62160
tttaattttt ttggtctaat gcttgtcttt caaatgcttg cattgttatt gc
#caaaatta  62220
aaattctctt ggccagtagc ttttcatgtt tgatatattc agcttctttt at
#ttcacaaa  62280
accagtatat atttattatt attattatac tttaagtttt agggtacatg tg
#cacaatgt  62340
gcaggttagt tacatatgta tacatgtgcc atgctggtgt gctgcaccca tt
#aactcatc  62400
attagcatta ggtatatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  62460
nnnnnnnccc ccatcccaca acagtcccca gagtgtgatg ttccccttcc tg
#tgtccatg  62520
tgttcgcatt gttcaattcc tacctatgag agagaatatg cggtgtttga aa
#accagtat  62580
attttatatt gttgatcatt ttgtgatttt ccttttcatt aattaacata ag
#aaatataa  62640
attattgcat ataggaaata tttgtattgc atgtaagaaa tatgaattat tg
#catataga  62700
aaggaaataa ttattgcatt tagaaatatt tcaaacagtg aaggaaaata at
#aaatgtcc  62760
atttcagaat agattggaga agcattaaaa atatctaaat gattaactga ga
#taattagc  62820
tggtaataag tatgtatagt gagacagagt tataatagat tgatggtcca tg
#aaagaaca  62880
aaggggaaga acaatgttta aatttagagt gctaagtgtg attacaaaga gg
#agatatat  62940
gggtgaaatc ataatttaaa ggaaatgata gaaagcatat aacattaaag ta
#tctaataa  63000
agtattcaac tatatattta atgtcaaaag accttatgct agattatgat gc
#aaatattc  63060
tagaatttaa ataaaaatac ttgtttttga aatcctattt acataagcaa gt
#agaaagtt  63120
gtagcaaaat cactaaaaat caaacaaaga aaagtgtaaa gattatcact gt
#tttttttt  63180
aaatcatcaa tattttagaa agtctgattt tcataaagga aaaaggggag ga
#aattttct  63240
ccccattaat agcttagctg tattttatct ttttaaactt caaatgaatt ct
#cctatttt  63300
ctctgagatc tcagactaaa tttcacattg aattgaatta acttttactc tt
#ctgagaat  63360
cttctttctg tccattcaac aagaagtgta aagtaggtgt aatacattgt ga
#atttttgt  63420
ctttaacctc agttctaagt tctagctcag cattaggccc taggtcagca aa
#atttcagc  63480
tcctatttct tctgcattta ccaagaaaga attctgattt aactatgaaa at
#tccaaact  63540
atagaaaaat cctgggatta ctatgtatgg tgtcttggtc actttttgtt ca
#tgcctagt  63600
aaatcaattg agatccatag gctgcacagt taagaatatt agcaatgact ta
#ccttactg  63660
tgtgtttgct atgtgctggt actattctaa gtacttaaaa cattgattca tt
#cataagtc  63720
tttatttcta gcacagagtc tacactctta gatcttgact aggacttgag ca
#aagcctca  63780
gggtggtaga aaagtaccaa gagatggaga ggtactaact gatatgacat ag
#agaagcta  63840
tccaactgtc caatcatctc ccaaaacaaa ttgagtgaga attttgacat gc
#acctcaaa  63900
attatacttt tgaggtttct gatacccttg attttcattt ttctttaatg at
#atcctaga  63960
tattttttac cccaattatg cctgcataca aatgaacagg agaagaaaat ag
#caagattt  64020
atcctggccc taagactcca gtatgacgat ggccttacct gaattattcc ag
#tttgttcc  64080
aatgcagagc ttcatggtag catgaaaatg gtgatatttt atgctctaat gg
#aacacgct  64140
gacctgttgt tctaaaaact ttgggaattg gaggaagtga gtagggagaa cc
#ctcttcat  64200
agtttatcca gaattaaaat agaatgaaag ataggagacc agtctgtgga at
#atttgatg  64260
gcttgataca tgtttccatg ttgattacca gctcccaaac ttcctttaca tc
#tacttccc  64320
tagtcttcac agaaggagta attcaatccc cttttccaat ccactcattt ct
#aagagttg  64380
taatcattgg tcatctaatc tgaagagcag tgtcactatt ttttcaaatg gc
#atgtcgac  64440
gttatagagc agtgattctt aaacttgaac tacagtcatt acaaccacct gg
#aggactgt  64500
taattactaa gccccacact cacggttttt gattcagtaa gtctggggta gt
#gcctcaga  64560
aactgctttt ctatggcttc cccagtgatg ttgatgctgc tggcctggag ac
#acattttg  64620
aggaccactg ttgtagaaag ttgttttata aacatgatgc tattctcaga aa
#atatgtat  64680
tctctgattc caaagtaata gtagtaatta gaatattttc attcttacct gg
#catgtcca  64740
gtattgaaac tgagaggttt tctttctatt ttgtattttt tttctagctt aa
#gccagtct  64800
gaaattagtc aggaaataac tcatttaagc atcaaataag atgatcatac ag
#tgaggtct  64860
aatactatga acatccatga atcattctta gtattcatga atctaatctg ac
#aaattctt  64920
aggcttactg tatttgtaac actattgtgc tataccctct gcagcaccac ct
#tgcggtta  64980
ggaaatctaa ttagaaaaca cacttaacat ctcataaaat gataggaaat at
#ttcctaca  65040
ctgacagtgg tgatgcgttt tggtcagcga aatcactggg ctctaggaaa ac
#atccaaac  65100
tacaaaagga tagccagtta tcaaagtgtt ttaaccagtg gacaggaata tg
#tcctgaga  65160
tactcttgct gtgtggaaat aagatgaatc caattgcaga gcttcttcag gg
#cccttgat  65220
gccctgaatt gcttaagaca caggaatcca ccagcgagtt ggatttcttc ta
#gtcctgag  65280
agacatctaa cagtcagtgc taatttgtcc aggtgtgctg agtcaaagtc ga
#cttgtagt  65340
ccttgaagtt gttaatattt gtatagctga gaaaggacag agcccttcac tt
#agtgatga  65400
cagtcactag aaatctggtg gcctagtgca ccaaattctg aaactaaaac ac
#cctgagtg  65460
gtaggccctt ttaataaact ttatactgaa cttaaattca aataattgtg ca
#gacaattt  65520
aaattgaagg tatatagagc tgaagttttc tgttttgtaa gttgatgtta aa
#ccatatat  65580
tcatttatgt ttattctttt aggaaagtga tcataacgag gtacactaaa aa
#ccatagag  65640
tattttctag aatattttcc actattaagt tagacttaca gggatctgca ga
#tggcaaag  65700
ttacaaataa gtctttgaat gtgcttattt taaaagtata gtatcaggca ca
#acaaaact  65760
tgttgattct taaacaaagt ggcatggatg ggggcattca aatttttata tg
#gactaggc  65820
aaaatgatgg tctatccaga ctcacctttg agctaacaca ctcagcatca ag
#acacagat  65880
ggatgggaaa gatgaccctg acccacataa gacccacatt cctgtgcaag ga
#tagaagca  65940
tgataatcag gaaatgatgg ttgttagtta cagaaaatgc attatggtga aa
#accagggg  66000
gaaagtgctt atgagaggaa gtgattggat tatggggaat gagagaataa gg
#atagatca  66060
ttcctactga gtaaattgct gtgatttata agagaaaggg tatagtgata tc
#ttggccca  66120
ttactgacta gattcatttc acaaacaatc ctaaatcaga atgtgacagt tt
#atggggag  66180
acaaacaaag ctcccaaaga tgcttataag ttactaagct tttaaactgg ca
#tattttca  66240
actcctcata cttttgccac catcagctcc atttattttt gtagctgaca tt
#cataaatg  66300
taattctgta gccaccctta tgtgacacta gtaatagttt actatatgct gt
#gataaaag  66360
ggaaaatgct ggatatattt tattatatgt tttgggattt tgttaaattt ca
#taagaaag  66420
atacctaaaa taattttata tgtatttaag tatattataa tactctacaa ta
#ctaaaata  66480
attaagtgct gttttataat agatgggcat tttggtgttc taaatatttc tc
#ttaaatta  66540
cctatgaatt aatcaaacag ttacctttca ttgctccaga caggtgaaac ac
#atattgtt  66600
atatattata tattaatata tattcagtta tataagttta cttttatttt tc
#agtttgga  66660
tttaggagct ctaatccttc aagaatacaa gttgacaaaa tacattctga ag
#gaaatttt  66720
tggcaaagga ttcaacacag aaaacttgtg taacaagaca ggcaatttta tc
#aagaactt  66780
tactgaaaat gcaaacattg tttacagtga ttgtttcttt taaaaaatga ag
#aaagaagg  66840
gaaaacgatt tttggaaaag ttcaagaaat ggcattaaag catagctcag ca
#aggggcta  66900
aataccttgc ttttttataa tgattgatca gtgcaaggaa attaaaatat tt
#agtagtat  66960
aggtgattat atgtgttgtc atgaatgatc tttgaatgtc atttttctct ta
#cctctgct  67020
tggggtcaca cactccctga tgagagattt gattgctagt attaaaggaa tg
#attgcagg  67080
gttgacattt tattgtgaaa gaagagaagt tgaaagcaaa gcgctatatt tc
#tttctgag  67140
ctggcataca gacacactca caagccagag ttttccttgg gaaaactttg ca
#ctttgtcc  67200
tcaaatgaga cccgaagaag ccattataga gcagagatac agaaattttt cc
#agatacaa  67260
gctaccgcag aaaaatctca caactttctt agccgcagaa aattctcaat ac
#atttttca  67320
tgatgtctgg gcaacgataa tgtgccactc tacttgcttg ctagaatgag tt
#aggttgaa  67380
aagtatagtc ccaacagcat cgagtagtat atgttacaga ggtacatgaa tc
#aaatagat  67440
gttggagatg atctttcctt tttgacgtaa ttaattttag cccatctttc tg
#gtatgagt  67500
tagataccaa ggatcacagt ctatcacagc cccttctact tcatggcgtt tg
#tctttttg  67560
ttcacaatag ccatcctaac aaaagaagac attaacgctg gtcttaacgg cc
#ttacattt  67620
tctggccccc atttcctctc ggattctctc attccaactc aactgggctt ca
#gcttcact  67680
gtggtccttg ttattcttag gacataccag gcgaaatcct gcctcagggt ct
#tcacgctg  67740
gccattctcc tcctggacac tctttctcca aacagccaaa cagtattccc tt
#acctcctt  67800
caaatatttg tttaaatgtt atctgcttag tgaggcatga gctgaccact at
#atttaaaa  67860
tagtaacgcc ctaagcatct tcatgcccat gaccttgtct catttttcac ca
#tggtacat  67920
aatacttcct aacatggtat ataatttact tgtgtattat atattcattt at
#ttatattt  67980
ttctaatata tattatttgt ctctctccat taaaatggaa gttccatggt ct
#ttgtctct  68040
ttggttctct tctatatttc cagcacttcc aaagtgcctg gcatgccata gg
#tgttcagt  68100
aaactgttgc taaatgaaaa gggttaaaca gtagaagctt tatggatgga tc
#caaagcta  68160
ccttgatcac ctgtatgagc tttttgtcct cttagtgcct agcacatagt aa
#gcacttaa  68220
taaatattta ttcattcaat gaatgcataa atttattctc aaggccaact aa
#acatttgg  68280
ttataataaa gacaagggga ctctaaaata ttttcctgtt ttataccact tg
#aaatgtgt  68340
ggccgatcag aaaattgttt ctgtccacac tggttcttac agagctggaa gt
#caaatttt  68400
tcaaataaca ttaataataa gggagcctta atacatttat acagaggtca ta
#tcccatcc  68460
ccttttatag agtcagaggc agaagagagg ccattgaaac ccacaaagca tc
#ttatattt  68520
atatttttca aggcaattaa ttatgctgat ggcaggagac ctcttatagc tc
#tcatctgt  68580
tatgtataat tacctaaatg aattaggcta caatttgagg cagttttcct ag
#gaccataa  68640
agctagcagt aaaaagaatg aaaatgtctg tttatgcagg gtatgtgtat ga
#ttccttga  68700
taccttagtt gttgcagaaa ctgtgtaccc aattctgtct tcatcattag ca
#tctcttag  68760
ctcatcaaat cgaatcctgg agcattcttt ctttaccctc tcccctggat gt
#tttcttgg  68820
caatgtaaaa ctggatcttt gagtacgggg tgtcaatgtt cagattattg ta
#cagttttc  68880
agaagtacaa ataggaagag tatctttgtc actccaaagg tatttgttca ct
#gaaagttc  68940
ctgaaatgta ttttctagat tcctgtatag ttatattcaa gtactattat ta
#aaatatgt  69000
caatgctatt attaaaatat ttttggattg agttgtgcac ctaaattcca ta
#gacataat  69060
gttatatgcc taagaaatat attctaaata tcaattactt attcacagtt ta
#aagattgt  69120
caccactatt aatctcttag tctgttttgt gttgctataa gaaagtatca ga
#gacttggt  69180
aatttgtaag aatagacatt tgttttctta tagttctgga agctgggagg tc
#caagatga  69240
aggtgcagac agatttgctt atctggtgag ggttgcaccc tctggagggg ag
#gaacgcgt  69300
gtcctcacac agtggaaagc agaagagcaa gctatccaaa tgcttagtga ag
#cctgtctt  69360
ataaggacct taatcccatt caccatggga ggtattctca tgacgtaatc ac
#ctcttata  69420
ggccccacct cttcatacca tcacattggc cattgtattt caacatctaa at
#tttggagg  69480
ggacatgttc aaatgatagt aacatcttat agctctctag tattgaaata aa
#ccttttga  69540
ctctcttcag agcatgtgat tcacttgaac cagatatact gcccatattt at
#accatccc  69600
aacttgcaag aaattatctg caatttaaaa acaaagacag aaactttctc ca
#ttctgatc  69660
ctatttgcct cattccaagc tcatctttcc atttgccaga taggcctctc ag
#acttctgg  69720
aggttctcaa actcaatgaa tatgaatcca aatttgtcat ctcctaccat ag
#tcttaccc  69780
caccaaaatc agtgtatgtt cctgaatgtg ctgttgtgaa ctgccaaaat tc
#actaatat  69840
taatgcatga gttagctttt actannnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  69900
nnnnnnnnnn nnnnaatttg cacccacatc aaattattcc gagttctttt ta
#ttaatctt  69960
tctatagtga ctctaggttt catctccttc tatctatccc ttctgtcact at
#tcttattt  70020
aggatctcat gttttacttg gccttttgga aagagcttat ctacactcag tg
#tttttcaa  70080
ataacttaac tttttcatag ttacctgagt tgtcttccta aatcaatgga aa
#aataattc  70140
ttttctcaaa aacctcagcg gaatcccact atttaaagaa taaactccaa at
#tctttaac  70200
gtaacaatca ggtactctct agcttaattc ctaaattact acttgggctt gt
#acattttt  70260
attcctccat aaatactggt ctctctgtga tagttctgtt tcttggattt ag
#ggattctg  70320
aatctttttt tgtaccatga atccctttgg aaatctggtg aagtttattg ac
#tccttcct  70380
agagtaattt attttttact tgtaaaataa taacattacc aagataagca at
#tctacagc  70440
aatacaactc tatctgtctg tgggtcctgt tgtttatgtc tttgtggctt tt
#ctatgatc  70500
ctccccttat cacagaagtg cccctaaccc tgctctatcc ttctcatcta tc
#aaagacta  70560
gtgcaattcc caccttcact gtgcatcttt accttgcaac cctgccccat ct
#gtatcatc  70620
actttgctct ctcattgtag attatatgtt atttatttct atttatccct ta
#tctttatc  70680
ttttatgata ccttggtaat tgacaacaat gtggcaaata ctgaactagc ca
#cttttaca  70740
tactttgttt tcataatttc ttttaaagca ctataaaata ttcatatgat gg
#ggaaactg  70800
aggtccaaac attttggtgt ttcaccaaga tcatacaact tgtattcttg ct
#agattatg  70860
agttatttga ggaaaggaat atttcatctt cctgattata tcttctccgg at
#ctgtggga  70920
tagtactttt tcaataatgt ttgcccatat gtatttaaaa attgaaaata tt
#gggaaata  70980
cttatctctc aatatttaat atcattagaa ttgactaggg gccccaggag ga
#cagaggtg  71040
tgtgcagcag tgttcttagg ttaatgtctg tgtgaaatta actgtggcta aa
#tctttccc  71100
tgcatactat tatctctcct aattcccagt ggcttcacaa attgaaattg ta
#cacataag  71160
gattttaaac agaaacattt ttaagatatt gtctcttgtt ttgcgttact ga
#aaaaataa  71220
caaagtagga caaattaaga aagtagaaca aattaaagaa tttaattgga gt
#cataagga  71280
attcaagaaa tatttgaaga ttgcatttct aataatagat cagaacaatt ga
#ataaccat  71340
ttcatattct ccaccctcag tgaaaacaat aaaatcaact caatttacat tt
#gtaaaaca  71400
atatatgtat actttcatta taccagtttt aattttcagc tgtgcttctc ta
#tctctctg  71460
tagtcaaata ctacgtttct gcaagggttt tcttaaaaca gcattgctag gt
#taactgtt  71520
ttaaaataaa aatatttgct taaaaaggtt tactttagca atagtaatgc tt
#tcctttca  71580
aaatattatt tcaagtttta aaataatgaa cttatgattt taattaatta ag
#ttttcatg  71640
tggaagttgt tcatctagag taactaattt taaagaattg gatcttttta tt
#tggtaatg  71700
cctttagcac tctgtgaaat ataaattaat gtaaaattaa aattaattta tt
#atgactat  71760
ccatttttca tggtcttttc tattattgtg ctgtagcaag tactaattct aa
#tgtagcta  71820
gataattaat tttctattgt catagctcca gatggtcctc ctgaaaatgt tc
#atgtagta  71880
gcaacatcac cttttagcat cagcataagc tggagtgaac ctgctgtcat ta
#ctggacca  71940
acatgttatc tgattgatgt caaatcggta aggcatgtct taccttctgt aa
#aaagccag  72000
tataaaatgg ttaataatac aagatttgga accagactat ttgaatttga at
#tttggctc  72060
tgttagacag taggaaaatt actttacttg tttgtgtttc aatgtctaca tc
#tgtaaaga  72120
ttaataatag taaacagggt atgaggactg aatcagttaa catgcataaa ga
#acttggaa  72180
cattccctga gatatggtaa atgctcaata aatataagat attagtaaca tt
#attataat  72240
atgttttatc agtgtataga atgtgtatat atatgtatgt atatatacac ac
#atacaagt  72300
ggttaaattg gtagtaatac aaatatctgg tttacagtac ggtagaaagt aa
#ttcataat  72360
acaaaatgag aagagagaag gcattaggag aaatatcttc cagataaaat aa
#catcagag  72420
ctaagtcttg aaaaataagt gaagcagaac ataaaaggta aatgggaata gg
#ggtgtaaa  72480
aaagtaagcc tcattcaaga aaaatcaagt cttttggcaa tcccaggcta ta
#gcattaaa  72540
aaaaataagt tctaagagat gaggctagat ccagaggctg actatacaac aa
#gttacaga  72600
gttagggttt tatgttaagg gcagtggggt gccagttggt gatacagatt tc
#tactgtat  72660
aacataggca tggttgcagt gtagaggata gattgagagc agtatggggg gt
#gtaaaatc  72720
aggcaaggag acaggaaact ataaaagggc aaggaaaaag aacagaggaa at
#gtagcaag  72780
agaacgaatg aaaaataatc taaacctata gaatttggtg aaaaatcaac ta
#actcatga  72840
tggtgagtga gtaggataat taaggatgat tgtaagttat atgacagaag at
#tatgagga  72900
ggaacagatc tgtagaggaa aggaatgagt tcagtattag acacactgag tt
#tgaaatat  72960
gtggcagtcc tccaggtcaa tacacccatt ggcagtatta aatatggatc tg
#gagctcag  73020
gagagaaatt ctggatttcc agatttgggt aatgttagta tttagaagat ag
#tcaaaatt  73080
ataagagtga atgagattca ctatggaatg tgcaaagtaa gatgacaacc ta
#aggacagc  73140
accctgggga ctatcaacac ttaaataaga ggccattgaa gagactgaat gg
#gagtagat  73200
agccatttgg atggaaatcc aggtatgaaa gtcaaaccct tcatataaga ta
#ggatgctc  73260
aatgatgtca ataatgcaga actgttagcc agaataaaga ctggaagtat tt
#cctttgca  73320
ccctgcttgg gttttgctgg gcctgatgaa cacagttttc taatagcatc tt
#atgcatta  73380
aattgtatag catagtgatt tctcctcctt tctctctgtc tcttgaccaa ct
#ttataatt  73440
ttattatgtc tttgtagtat tccttaaatg gagatataat gcttctatct ca
#aaagacct  73500
gtcatcatta aaataaaatt gaaagaattg ttgatgtatt tgttctccaa tt
#cagtctct  73560
attttctgtt ccttttgtag agcatatttg tgaagatttt agtatgtaat ta
#gccaaaaa  73620
taattagcac gaatgatgaa tgccctggga atatgcatta aaaacaaatt at
#aaaatgat  73680
aaagctttac tctgtcaaat gaaaggcact ttattaatga aaatagttct cc
#cttggaaa  73740
ttctgcttaa aggaacaaaa aaaataaaac atattaagaa gtgattttgt aa
#tctcattc  73800
ttgtagcctt cttgctgagt ttcaaagtga gcaagggaaa gagggtagaa tg
#ggaagata  73860
acaaatattt taattgctta ttttctacaa gttacatgtt catctcttcc ta
#ttcattat  73920
cttattatat gttatccagc aatattttca tataaacatt attaccttca tt
#ttgcataa  73980
aagaaatcta aggaacagag acggtgaata acttctcaca gagctaagac tt
#ggctaaaa  74040
ctaacagatc aacaatggtt tgacaggaga aagggaaggt cattaaataa ca
#aataaaat  74100
tcgccaacat aaatatagcc tcaccaaaac tcctttagat caacaatagc aa
#gaacagat  74160
tcagatagaa cctagtaatt cacagtttct ttaggattct tggaattaag ta
#gaggtatt  74220
tccttccttc cttccttcct tccttccttc ctccctccca ccctccctcc tt
#cccttact  74280
tccttccttc cttcctcaca cattttaaaa tacttccaat gtaccagaac tg
#tgctaggt  74340
gctggatatg tagaagtgaa caactctgat aaagcacttc tgcagctcat tt
#cattaata  74400
tgtaattatc aacattcaag aatcactggt tcccagacta aggaagaata ca
#tagcattg  74460
cacttgggac ttattgtgca gcctgtcttc tacaaaatac tagccacacc ga
#taaaactc  74520
ttaactttaa aagtgtaaac aaaaattgtc aatcttaata aaatgtaaat at
#catcctag  74580
atgattctgc tggaaattaa tgcatttagg atcattttca ttgttccttt ta
#ctctttga  74640
ctgaacaaat tgttatgagt agcttctgtg catcaagaca aggatgaaaa ac
#ataaagct  74700
ctgctgtcag gtagctcaca ccctagtggt acacactgga atagaaacag ct
#aattatag  74760
agtttgaggt atgaagtttt gtggggaata taaggtaaca aaataattaa ag
#ttcctgtt  74820
atgggaggaa tagaagataa aggagacttc atagagcagg ttaaatatat tc
#taggactt  74880
gacgaatgaa taggggtaca caagatggga aagggtggag gcggggtagg aa
#gagaaaaa  74940
aaataggaag tggggcagga agaggagaac cagagtctaa ttgctgataa tg
#aatataaa  75000
gtaacacttc aaaaatgatg aaagacattt tataacaata gattatcaag ta
#caatatga  75060
gcaaacaaac ttggaattga ttgaaggaaa atgagtcaga aagatgtgat tt
#cagtcctg  75120
ggtaagtgga caagtaatag ctaacaacaa caaaggtgta gtaggtttaa ta
#aagaaagg  75180
taatgatgat cttttgtact gccagatttg aggaccgaga attcctttca aa
#ttttgtta  75240
aatactttta aagatataat atatgcgtgc catgtcatat tttgcgactt ga
#tatttgtt  75300
atctattgtt ttaatggaag gcattggaag agtataattt ataaattata ct
#tataaatt  75360
ataaatttat aatttataaa ttataaatag ttaaatttat aagatcaaac cc
#agtgacct  75420
tgtggaagtg tagaattcta tggactcttg aaagacctgg gctcaaatcc tt
#cctctgct  75480
actaagtaac actgaggaag tcaccttacc tctataaaat cagaattcaa at
#agctataa  75540
aagacaagtg acatgaacca gtagtcaaag tgaagccaat tgagtggggc tc
#caatgaat  75600
gggacccagg cccctttaca gaggtcaata gttacccatc tctgcacctc tc
#aataatat  75660
tttttcagca tgaaattaag cctagtctta aggaaaatta caaaaagcat at
#ttttatgt  75720
gatattcaaa tgttaacaac tagttaaata cacattttct gccagtggca ta
#tattcctg  75780
atcaatagga tttctacgct gatttgtttt tcttccattt tcgagaagtg gg
#gcatttct  75840
gtccactgct ctgtcttaag gtgggaatga tctatttgac tgtatgcaac ga
#tagtatta  75900
tttatatcat ccttttacta tgtttctttt ttttcttttt ttatagcaac at
#cttttttt  75960
taaaaaaaaa ttgagttaat tttatttaca ttacctcagc aaacatctct at
#aaatgagt  76020
ttccaggaca acatttacaa tatagttata ccatatgcaa atcaatgtgt gt
#ttcgccat  76080
attatcaata aaatatgttc ttagcaaaga gcattaaaag aatacattga ac
#caaccaac  76140
caaacaaaaa atatttcaaa gttataaggg aaggtcaagt tgaaaatgga ct
#taatagtg  76200
ttcactgtgt ataaaacctg gttttaagtg tttcaattaa gatacctgaa ag
#tagtatgt  76260
atgataggat tttgaatttt ctcatggtta tcttgggaaa agcccttcta ct
#tagtgcta  76320
gcaagtttag ttatgtttaa tatctggagt gaataggcca gaacctccat aa
#aggacaga  76380
ctatgtttga acaaatcata tagctacatt tcatatgcct aaagacactc at
#ttatgcac  76440
attaataatt atgacatcca caattaatta ctatccagtg ctacacatag ta
#ctaaatca  76500
gagtttttca aactgcagcc atcatcagaa tttttaaatg aggtggaata aa
#gttaaaaa  76560
gagcagaaaa tatcaaagtg tacttcagaa agatggtgta tttctgaaaa at
#gtgttaca  76620
gtcataagat acgtatatat tttatatcta tcagtcttat cttctgaatt at
#gttacaaa  76680
gagtgtttcc ttttgtgggt aatggtgaaa aaatattgaa atctatgtgc ca
#actacttt  76740
agatttgtcc tttctaaatc tcagtgaaac actgtaaata gttgttatta gc
#ccaatttt  76800
acatgcattg aaagactaga ctgtgtaggt ggtttctcaa atactacagg ag
#ctataagt  76860
ggccaatttg ggatttgagg cctgtgtgat taggtaccaa aacctctatg ct
#ttcttcta  76920
caaaatattg gagtcaaaag tagagtttca ttgactgcaa agatgatttt tg
#cttattta  76980
tttaatgggt tggttaatca cggttggctg gtttgtcttt tttcttttac tt
#tcaactat  77040
taaaataatt aataattagt aagctgttat aatagcactt tagatttccc ag
#agcaatct  77100
gattgtaaaa taaataaata caaatttggc tagataaata catctcacgt ag
#ctttgtat  77160
tattatgttt tggtgactca gatttcaagt gctgcttcct taatttttac tt
#atattttc  77220
ctataggtag ataatgatga atttaatata tccttcatca agtcaaatga ag
#aaaataaa  77280
accatagaaa ttaaagattt agaaatattc acaaggtatt ctgtagtgat ca
#ctgcattt  77340
actgggaaca ttagtgctgc atatgtagaa gggaagtcaa gtgctgaaat ga
#ttgttact  77400
actttagaat caggtaagga gaatttctca accttgctaa aaattgactg ag
#atttagct  77460
ggctttctta cagttcatca tactccacca aaaaaggata tgtgttatga ga
#agttttta  77520
aagcatataa acaaaaaaat tagtgactct ctgcaactga caaaaaggaa ga
#tttctatt  77580
tatatttttg aggtaaagag gagttatgta gaatattcaa tccttgtaaa ta
#cagcaaca  77640
attaaaggta tccgctgtat ttctttgcac ttatttaatc tgctagttgt tt
#cagaaatt  77700
aagtaagctt gcctaagaga taatatttcc aactgtctat atccaataac ac
#ttcaacta  77760
aaattctatt tcaattattt ctgtcccatt atttgaatga atattaaact tg
#taatactc  77820
tgtgagtatt aaataatctg gaattcgaaa gtagaatcca gctcacattt at
#cacagctg  77880
ttgtcttccc ttagtcaagt aatatatgtc ttattatata actctttgat aa
#atgtcaga  77940
atacatacag atttcctcaa gttcttatga acagggtctg aatgaataat aa
#gattgtaa  78000
ccaataagaa ataaatttgg aaatcaacat cccagaactt gcttgcccca tc
#ctccttca  78060
gactcctgat gttctttgcc accagatata tcattggaaa aagcagatga ag
#ggatatgt  78120
tgctatagtt tatttgttgc tatctgtaag gtaagtatag gaagtaaaat tt
#ttttacag  78180
ctagtttttt tcgttacatt atattctcta tgcattttgt ctgtaaagtt at
#ggttctaa  78240
attaaaaggt aaattttatt atcagcatcc taaaattcca tttgttccta tt
#cgtctgcc  78300
aagtatcaca ggtatctatt ttctgattat gctttttact tctcaatccc tc
#ctacctgt  78360
gaggaaagat atgatgaatg tactcacatt tataccataa agcattgttt gt
#caaatctt  78420
aatgtgctat ctgtttcaag gatatcacaa tttaatacat ttttactaaa tc
#tctaagag  78480
tagaatttta tgtgtataac caaaaatctg ggtactagga aattttttac aa
#cattgaga  78540
gaattccttg gtttatctga cttaaaatca catcctaaat ttagagaaac at
#ctcataag  78600
aaaatatatt tatgacacag cataaaaacg tgtagtaaca aatgcaaaaa ta
#tctctctt  78660
gaaccaactt aacctttatt ttagctttgc atttttccat ttaaaatgaa at
#atttgaca  78720
caatagtacg tttatctgct tctctctctt ttattctttg ctgttaattt at
#ttacattt  78780
tttgcaagat aatgaagctt gaatatctga actgttgaca gccaaatatt ac
#atttcttc  78840
atggaaattc tttacttagt atggaaggat ataactattt caagttgaac aa
#aatagata  78900
tagtcattca atcagtcact tatataaaga acactaatta tgttatgcat ca
#agaagtag  78960
ctcctttatt cataaaataa cttttatcct catacatatt ttaataatgt at
#tggtgctt  79020
agcttgtcat atgttaagct gttatttatc taaaataaac taaaatattt at
#actatata  79080
aagaactctt aaaacccagc aatttaaaaa aatccaatta gaaaattggc ag
#aagacatg  79140
aacagacatt tcaccacaaa ggagacattg ttggtaaaac aaacaaacaa ac
#aaaaaatg  79200
acaacataag ttttcaatac cattagccat tcggaaaatg caaattaaag cc
#acaataag  79260
gtattattgt ctatgtacta gaacagataa gataataatt taaaatatgg cg
#atgatacc  79320
caatgctggc aagggatgca gaaagactgg acctctcata cattgctagt ag
#gaatgtaa  79380
aatggaatag ccacaatgga aaataatttt gcagccactt ataaaactaa ac
#atgaaatt  79440
actgtgtgac ccagtagtca cactcttggg cactgatcac agagaattga aa
#aattatgc  79500
tcacacaaac atctgtcacc aagattgatt gcagttttat tagtaataat ga
#aaactgga  79560
aacaacccaa atgtttttcc atgattaaac aaactctgct acatccacaa aa
#tggaacac  79620
tactcggcaa taaaaagaag aatgtactat taatacatgt agtatccacc tt
#gatggacc  79680
tcaaggccat tgtgctattg tcattttcaa aatgacaaaa ctatacagag ga
#agagttat  79740
tagtgttgtg aagaagcata tactgcaaat aaaagaggat actaggagag ag
#tttcttta  79800
gggtgatgta atagttttat atcttgttta cggtggtggt taaaggaatc ta
#tacagaag  79860
acaaaattgc ataaaagtat aacaaaacat ggaaaggggt gaaattggga ta
#aagtctgt  79920
agcattaaca gtattgtacc aatatcagtt tcctggtttc atataaactc ca
#gttacata  79980
agatattacc aatggggaaa actgggagaa agttaaatgg tatgtcctgt tt
#ttgccact  80040
tcttttgact ctaaattgtc atgccattgc actccagtca gggtgacaaa gg
#gagaccct  80100
gtctcgaaaa caaacaaaag attaaaatgt catagaaaca cattctgtgt aa
#aaataagt  80160
gcatataaaa caaacaaact ggatcaccat tatggttgct gtgaattaca ga
#tgtcaatg  80220
attctataat gcgtcagtca ttttgctagt ttttgcagtt tatatggttt aa
#tttgtgga  80280
atactcttta aaaacagaag ttcaaagcaa ataaatttat gtggagataa aa
#aggaatac  80340
aatattttta aaaattaatt gttaaatatt ttattttagc cccaaaggac cc
#acctaaca  80400
acatgacatt tcagaagata ccagatgaag ttacaaaatt tcaattaacg tt
#ccttcctc  80460
cttctcaacc taatggaaat atccaagtat atcaagctct ggtttaccga ga
#agatgatc  80520
ctactgctgt ccagattcac aacctcagta ttatacagaa aaccaacaca tt
#cgtcattg  80580
caatgctaga aggactaaaa ggtggacata catacaatat cagtgtaaga at
#ccgtagct  80640
tcagttaatt acccaaatga caatgtcagt ttatgaactt ggcatttaaa aa
#tattgcag  80700
tttgtgtaca catgacattt cccatatctt tttgtgagat tgtttgacat ct
#caacaaaa  80760
ataaattttg agaactgaaa ttacctattt tctgctataa tacaagtact at
#taaattaa  80820
aatatgtaaa taaccaagaa gtttgcacaa taatagtaga aactcagaca ta
#aaagagaa  80880
agaaaatgca cattaaaagt aaaagaacag tgatatataa agagataact ct
#gcctaaaa  80940
aaaagctata tgattatgaa tttaaaatgg aaaagcaaat tttaaggaca aa
#agacagaa  81000
ataattgttt acctgtttaa aattctcatg cattttaacc aagtattact aa
#aagctaat  81060
agcattttat gtcttaattc taaattccct atatttggac agaaatgtat gc
#atgagttc  81120
atatacatac acagagacat atacagacac aatttgtttt attccttgcc ta
#cttttaga  81180
tcatcttgaa attttcaaat aaaattatat ggttcagaga aatcatcttc ta
#agaaacag  81240
aatttactct aaatcttcaa gtagtttagt aatctgccta ccaactcttg at
#taatatca  81300
atgtaattat caggtcattg ataataattt gtatatgtat atgtgtataa aa
#tgaatata  81360
tttactactt ctctcagtca ctttgacttt atatctttat aaaataaatc tt
#ttggggat  81420
tctttttgca tgtcccatta agtggaccac cattgtgaaa gatcgattag ag
#ggaagacg  81480
gtgactaaga gaataaagta acctgggttc aaatactggc gtctgtgcca gg
#gcagcttt  81540
atcaaatctg agcccagttt tcttatgtga aaaattggta ataggaataa ta
#acttcttt  81600
ataggatatt tgtgaggatt aaatattcat agttatggta ggtagtgaat gg
#tacatata  81660
ttttggctat tggaagagag aaaataggaa ccaaaaatgt gcaactaatt aa
#taattttt  81720
aaaaatcctg tttgcagact gcaatttgca gtatccttaa aaccttgaag tt
#tgttagga  81780
tgtataactt tagcacctgt attgacctac tgaatcaaaa tctgcatatt tg
#catttaac  81840
aaggtgtgcg aatgacttct ttgcacactg caatttcaga ggcagtgccc aa
#attttcac  81900
ttattatttc acttaaatgt tagattctac cataaagaaa taaaaataat gg
#accatact  81960
ataacatacg ttttttattt ttaatacttt ttttttgaat ttacaaactc aa
#atattttc  82020
tctaggcatt ttcaagccac attttatggt cttggtttat ttatcatatc ta
#ccacatgt  82080
atattgtaat attaactcaa taaaaacatt ttaaaagtat ctagagtgtg gg
#agggtggg  82140
ccactaatat ataaaacaaa ttaagtaatt ccaataaaca tttcgtatac tg
#aattgggt  82200
ttatcgagta caatgaaata agccaagaat atagtctctg tttaatatag ca
#agataaag  82260
tgaagaaaag aagattctct gtctacagct tccttagcac aaagttaatt ga
#aaggattc  82320
acgtttgtgt aaatcaccct ctgtgtatac aaacagaaat gttttatgtg ta
#tatgctgc  82380
attatgcagg ttatagcgtc agatactttg gggcaggggt gaagaagggc at
#aaaggcca  82440
tctttcaggg gaatgattta atacaggaaa actgggaggc tgaaggaata gg
#atttcatc  82500
ttagagaggg aaaaaaagag gatcttgaat atggatttac agaaggccag ag
#ttacctag  82560
ctacagagag aaggaacaga tgttagagta gatgaaggga gagcgtagat ac
#agtggctg  82620
tagtgctctg ttcttcctac attcacatta aaatcatggt cagtccaggt ct
#cagtgata  82680
gggctgttta gatcactcag cctttgttct cagcgtttag taccagaaca tc
#aattttta  82740
gaaatacttc attgttaatg ttcttcctac atatattata ttcaagtgca ag
#aaaataca  82800
attaatagac tatatgcagt tgttttttaa agaattattt aaaattacat gt
#taccataa  82860
tcagttttat atatatatat ataactatat atatacatac atatatagat ac
#atgcatat  82920
atatatatat acacacacat acataagcaa tcacttgaaa atagtaacaa at
#atttgttt  82980
gttttaggtt tacgcagtca atagtgctgg tgcaggtcca aaggttccga tg
#agaataac  83040
catggatatc aaaggtacat acatgagcta ccttcctatg aaatgctatt aa
#tcagtgat  83100
tataatttaa attccatact tgaaataagg atgtagacaa gcctttaagt ga
#taaatatg  83160
catatattaa gcacatacta agtaaaaatg tgtggttatt aaagctatag tt
#aaaaacgt  83220
ttaaatgatg atgtgaatta ccatgttaaa taaggagaat gtctttattt ta
#tatttctt  83280
taatatattt tatatttcta agtttaaatt tttaaagaca aattttatag tc
#cgttattt  83340
gatgtttctt taaatgttat cgaaaagaaa gtgtgtttaa attgcctatc at
#tagacttt  83400
gactaggtct aattagatta ttagattgtt tgactgattt ttattttgga ag
#tgagattc  83460
tttcagttaa ttaaatagtg ttttttgaac taccatgtag gttggtttat ga
#ttctgaca  83520
gtaaagtaaa tctatcaatt catgattctg gcaagtattt tttatagaaa at
#ataactaa  83580
aatttgggtc atcctttcaa aataaaacaa acaaacaaac catggaaacc nn
#nnnnnnnn  83640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  83700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  83760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  83820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn  83880
nnnnnnnnnn nnnntgatta aaggtgacag cattaggctg ggtttagggt ca
#aactgctg  83940
gtattgaatc atggattagc cacttgatat ctatttgact ttgagaaagt tt
#cttaacct  84000
ctataggcct gaaaaatgga gataatacta gttcctatct caaagttact aa
#ctttgagg  84060
attaaaagag aatctgaaaa aacccttaag acccctgcct ggaaacatgt ac
#tattaaga  84120
ataaaaaata ttcactgtta gatgaaactg ataaatttta tctttttgtc aa
#tggattat  84180
ttatataatt gtgatactct ttataagtgt ttgatttaaa ttgataaatt at
#ttactttg  84240
ggaagtacaa atgcataagg tctttaaaaa catcaattat ttcacaaaat ga
#cttcacaa  84300
agaatagtat gagtcatacc ttttaaattt atctttgtta ttcagtggca ga
#cgtgtagg  84360
tgtacagata gcaatacatg catcactttt atgctttagt aaaacttccc at
#ttcagatg  84420
ctattcccat ccccatgcca ggttggttaa tcttgacttt tactccttac ct
#aaggcagg  84480
cagacttacg acttctagtc tagagaagat atatgaacaa tgtcttagtg gt
#gggatcct  84540
agagaaatta tgttttctct actaatacac attattttat taatgatgtg ga
#atattcaa  84600
ttggtagtag tctcatgaaa tttgcatttg acagatatta tgaagttgga ta
#gtaatgtc  84660
caatgctgga ttcctctaac tggaaatctt ttcctgggga ctcccaagtg gc
#ctggctga  84720
gaatctcaga actacctgaa acctgagcct cttcctactg aatcctgcct tt
#catcttcc  84780
cttttacagg tgtcatacct gtgatctgtg gcacttactc cttccctctg tc
#ccttaatt  84840
cttcacagat aattccccca aaaaacctct tacacatcca gtctcatttt ag
#cctttatt  84900
tctcttagta cccaaactga tacattgagt aagaaatttg catttgaatc tg
#atgctcaa  84960
aaaagagtga actacagaac cgagtcaaaa aaatgtgatt caaatgttga ta
#gttatctt  85020
tgataactgt atgacataag ctcttttccc tatctacaaa ataaaaacaa tg
#ttgataat  85080
cctgtgggat tattgagaag ctttttaaaa aagattctta aaaatatgga aa
#ttgaaatt  85140
tggttaagta acttactgat gctcaagcac tacattcaca cacacacaca ca
#cacacaca  85200
cacacacaca cacacacaca gtgagctata agaccaaatg aaacaagcag ag
#cttctata  85260
catatatttt ggagatattt gtatgcattg atgacaaatt atgaattatc at
#ggctcttc  85320
tagaagttat tctgttaatc tgttaaggtt aaaagtacat atatcttttg tt
#ctagaaat  85380
tctgctctta ggaatctatt tcatagagac aaaaagatca gtaaataaag ct
#cattgtaa  85440
aacaaagcta attattgtaa aacatgttta aaaactggag gaaaagtgaa tt
#cccatcac  85500
cagatgaacg gttgaataaa tatgatgcag ctgcaccatg atatataata ta
#gtcattaa  85560
gaagaatgag ttagctctgt acctggtcac ttggaaacat ttaaccaagt ta
#tatttaag  85620
caaaaaaagc aatatgaggg gtaattataa tacatactag agccccatta ga
#aaaagcaa  85680
acagtgagaa gagtgtgttg tgcatgacta tttatgtatt tttatatgat ta
#tgtgaaca  85740
tggaaaaaaa tatgggatgc tatcatctag atgtttagca tggattaact gt
#gggagggg  85800
tgctagtatg actagaacag aaattagtaa accagctaaa agaagcaaaa ga
#aactacac  85860
taaaattata gtaaaaagta aatatgttta tgcatttata aaaaatatat at
#gagtgaga  85920
gcatgtataa attgaatttt taatatgcaa agaggagtca ggtgcctgaa aa
#tcacacct  85980
gggctctatt atctcaggga agtctcaaat gtataattat gctttcagga ga
#taataatt  86040
gctaaatgtc tgctgtctcc aagcacaatt ctctataatt tgttatttat gt
#ttgtcatc  86100
actttatctg taaattaact gcatgaaagg agaaagattt tttcttttgt tg
#atgaaaca  86160
ataacatcaa ttgcagtgat atttcttctt tgtttatagc tccagcacga cc
#aaaaacca  86220
aaccaacccc tatttatgat gccacaggaa aactgcttgt gacttcaaca ac
#aattacaa  86280
tcagaatgcc aatatgttac tacagtgatg atcatggacc aataaaaaat gt
#acaagtgc  86340
ttgtgacaga aacaggaggt atcatcacat gtcaatttat cttgttaaat tg
#tggagtgt  86400
agattactga gtgctaaaaa gaatttagtt caaattaaga ttgactccca gt
#tatcacac  86460
acctcttgag attaatagat tgtcaatatt attattaatg ataccaatca tt
#tctttgta  86520
aataaataaa ttatttattt attttatttg taaaactttt ataaatgtca tt
#tatttata  86580
ccaattattt attctttttt acctatcaag aaaggcacag ttaaaatatg tg
#atttatta  86640
attccatata ctagtagata aacatgtttt gattttggta agatggaatc tt
#gatagctt  86700
ctttggaggg gtgaacaagt gagttactct tgattgaggg atgctctttc tc
#tacctgat  86760
aaatcatcct ttataacagt tcctgtagat tcacatgtaa cagagaagaa ca
#gggttacc  86820
tgcctataca ggtggatcac ttgaattatc tctggtgact gatgttgcat cg
#agagtccc  86880
cttatacaat tataaaaaca ctatttataa ttgtaaaaat atattcatat gt
#tacttgga  86940
attattgttc tctttgtttc tgaaaacagc tcagcatgat ggaaatgtaa ca
#aagtggta  87000
tgatgcatat tttaataaag caaggccata ttttacaaat gaaggctttc ct
#aaccctcc  87060
atgtacagaa ggaaagacaa agtttagtgg caatgaagaa atctacatca ta
#ggtgctga  87120
taatgcatgc atgattcctg gcaatgaaga caaaatttgc aatggaccac tg
#aaaccaaa  87180
aaagcaatac ttgtaagtat aggttatatc taccatgcat tctgttagca ag
#ctagttag  87240
tatctttcat ccatccatct gcctgtcctt tcatctttcc aataagcact gg
#atgtccgc  87300
cacgtatagt gacctgattt ttctggcact aggaatagaa agataaactg aa
#aattattc  87360
ttacattcca taaacataca gtattatagg ggaagcaggc aaccctaaga gt
#aattatga  87420
tttgatataa gttacataaa gaccatatga aaaatgtgct attggagaac at
#aggtatat  87480
aggagaattt aattctttct gtagaggaca atgtgactaa tgtgtttttc ac
#ttattatt  87540
ttaccatcca tgctgatgta caggattttt gaaacactat cctatccttt ga
#tttaacag  87600
tggcttccct ttatgtcact cataacaata actctctgct ttttatctca tg
#aatgagtg  87660
atagaaatat ttaataccac ctttaatatt tagctttttg tagcccctaa aa
#acccaaca  87720
ttttaaaatc aatttgatat tttggctgta ttaaattatt tgctaaattg at
#tatcttcc  87780
ttttgaattg attatgttat ttttgtattg taagactaca atttttaaaa ga
#atcatctt  87840
atccttgtgt gattttcaaa atataatttt tactagtaat tttttaaatg ca
#ggtgcttt  87900
catttgtgcc tgttagttaa aacattatca aattctttac aaatatccta ag
#ccaagtta  87960
acattggaaa aattagagaa attaggcaaa taaaaataat gctttatcat ct
#ctattaaa  88020
tgcaattact ttggttcaaa ttctaggtta ttgcctgaat agctatacac at
#atgatagt  88080
tataaaaatg atatactacc aagtatcatg tttattcata tttatagttt at
#ttattttg  88140
catatttgtt cctgaaacag actcttcata taacaaataa aatcataaga at
#tttataat  88200
ggtagaggtt caatcatgta ttgcaacgta ttggttttat gtttttaaat gc
#ccttgtgc  88260
ctttattttt aaattaagta aatttcaatt gtctctgagg atcttagatt ct
#ttttgtaa  88320
tttttaagct tgatcttctt ctgtatcctt tacttcaaat gctatggaag ca
#aaaaagta  88380
tacaaatgca actgtgcaca cacagaaata acaaacattt tcttaatgtg tt
#tatatgtg  88440
aacaagacaa gttctatatc atcattttaa tctaattcac tagcatttgc aa
#aagtgatt  88500
gaggtataac agttatgcct tttatttata aattatgtta gtgtaacacc ct
#tcacagat  88560
atcaaatcat tccatctaaa caaatccttg aaggaggtga gctgattcag tt
#gttcaaac  88620
tgctaactgc tcacgagttt accaaatttt tagcccctgc ctcatcaaat tc
#aatgggtc  88680
aaagtacgag ataattattt gtctcatata aatatagcat atatttctcc tg
#atgatgat  88740
tccattccaa attttcatct tgtaaattca ttttcttttg aattaaataa at
#agttttta  88800
taattacttc ttgagttatt cataggaaaa atcacatgat atgcaaagtg tt
#gatttttc  88860
tttttttatt ttatagattt aaatttagag ctacaaatat tatgggacaa tt
#tactgact  88920
ctgattattc tgaccctgtt aagactttag gtaagacatt tttgtaattc at
#ttataatc  88980
tcaacatatt tatcaaagtt ggaacattta ttagtaaatg tattaatcca tg
#tctagatg  89040
ttttaaaata taaactcatt taaatgttaa ttagcctctc tagtaatatt tg
#tgggtttt  89100
taaaattttt tcttttaggt ttaggagtac ctgtgaaggt ttgttacaca aa
#catctgtc  89160
atctcatctt aactatcctt taagttaggt cagtgcttct cagagggatt tt
#atacccca  89220
ggggatattt ggcaaagtct ggagccattt ttggctgcca taacaggatg gt
#agtggtgg  89280
tggtgcatgc tactggcatc tagtgggcaa agattaggaa tgctgctaaa tt
#tccacaat  89340
gcacaaaaca gcccgtaatg tcagtggtcc tgaggatgag aaactctgac tt
#aagcccta  89400
atgttgactc cattttacag atgaggaaac caacacccag attctttcag ta
#tttaagtg  89460
gctaggccag gattccaaca ttacagaaca ggatttcata acattacatt ac
#aaatatgg  89520
gatttagacc tgggttcaaa tcttggctct gtcacttgag aaaataattt aa
#tttctata  89580
aatctgagtt tcctttgttg ggaaaatatt gataagagta tcatccttga gg
#ggttgttg  89640
aagttttgtg taaaacaaca tatataaata tattaatatt ttatagttag ta
#aattttta  89700
aagtttaata gcttttttgg ataggttata ataaaatatt ttagaaacat tt
#ttatttag  89760
gagaaattat ttctctagaa tttcactgag aggatcacaa cattctacat tg
#tttgtgcc  89820
aggccctcaa aagccccagt ttattcgtct taaagaattg catgaacagg gt
#atttctgg  89880
ggcaccactt gaaaatgtaa gacttcatgt gttgcccaga tcctggcgag ct
#gttgctca  89940
gtgtatcttg aactgctaat agacttcagt gagagttatg actggagaaa ga
#cggattgt  90000
cccaccattt ttagccagaa attctcattg ggttatggaa atactaattg ta
#taaaaagc  90060
cagcctccac agcctctaca tgtagtcaag gaaactttgc atcttgaaga aa
#tagagggg  90120
gcatgtagtt tgctacatag atgtttgtag agaaataaca aatttctttg gc
#taaaatgt  90180
ttgtttaatt ttatacaaat cattggtttg attaatttta cccaataatt tc
#atcatttt  90240
aaagctagct gattagtttt gtggttttga aattgtatca agtgtttctt ca
#tttgatag  90300
gtgagtctat cacactctga tgccaccaca gtaaaataaa tgtcttcttg tc
#atcagcat  90360
aatttcctat aggttacagc attcataagc cattacttca gctaagtagt ga
#tcctggtg  90420
catttgccaa tggaaggtaa aagacctaga caagatagat aacccatgtg tc
#ttaggaga  90480
taatatttta taggagcagt gctgaaagga gctagccttg ctgtattgta tg
#atgttgtc  90540
tttcatcaac ttactggttt catacagatt attcatggga aggcaacatg tt
#ccgtcagt  90600
tatctgagag gcaaagttga gacattcagg gtaatggaaa tgagaaagaa aa
#gctataaa  90660
agggggggag cgccaagcat caggaaccac agtgcacagg agcatgattc ct
#tagattct  90720
gctaaatggc ttctctctgc ccaatgatgg cctcatccag cactataagt aa
#tctcaaag  90780
agctcctcag caatggtctt ctctttcttc tttccactca cagtcaaggt gg
#tggaatac  90840
aaccattaat cctggaatgt agcagaaata cacagtcagg tttttgattc ct
#tctttgga  90900
agtataacca ctgccacccc aatcatctag gtatgaatct ttgtgtgctc tg
#gaaacaga  90960
aggagtctac agtgagtaaa agatgtgtaa tgaaggacag agcacaggat cc
#tgccaaga  91020
ctaaggaagg agggactggt gaaatgtaga ctggacacaa tatatagaaa gg
#cactgggc  91080
tgctgaggga tagtgacaag gaagggtcct atgtgtctat gatcaaatta ct
#cagagttc  91140
agtgtatttt ttgtagacca gtgacatgat gacagtcttt taggttgctc ct
#tagagtga  91200
tcttccaggg actctctcct gagatacagc agctttgtta attggccttt gc
#cctacagt  91260
gcttattctg gattgaccac atggagttct gctatttaga tagtcattta ta
#gcgagtaa  91320
gacagtgaca agtggaatca aaggaacttg cttggtttgt aatcgttagt tg
#tagtgaaa  91380
tgagaatgca cccctggagc agaattcctc aatgactagc aaagcagccc ag
#ccatttct  91440
ctggttaatg gatttaacac catcaattac tgttgtcata tttgctttct ac
#cagactat  91500
tgagtgtcgt ggttctatgg agattagagt cactttcata ggtcaagaaa ca
#aacaacat  91560
cccctagaag tggtcctggt ccatttgaca ttgatagaac gctgtagatc ag
#gggtgtcc  91620
aatctattgg cttttctagg ccacattgga ataagaagaa ttgtcttgga ct
#acatataa  91680
aatacatcaa cactaacaat agccgatgaa ccaaaaaaaa ttgtaaaacc at
#atcctaat  91740
gttttaagaa agtttacaaa tttctgttgg cccacgtcca aagttgtcct gg
#gccacatg  91800
cagcccatga gctgcgagtt ggacaagctc gccacagatt caaaagagtt ct
#tagtaaaa  91860
gaacattgcc agggaagaaa ctctagaaga actcaaaaag aaaacaaagt tg
#atcaattc  91920
tccaatggtt agtggcaaga atggtttcat ggttgtgaga atgaaggcag gc
#aaataata  91980
aagtgcattc atataatacc cctggtgtca tcagaagatg acaaagggtg at
#tgagtcct  92040
ttttttctct caaatatgtc atgtgttggg atatatgaat catttgcagc ag
#gctaggga  92100
ctcaaacatt cctggtaagc tgctgaagac atatgtgtgc atgtaatccc ag
#actacaga  92160
gagaagtcta ggtcccatca aggtcatcca cccaccaggg gataagcatt ca
#ttcactgg  92220
tattttgcac accacaggca atgagcacta agccgagttg cctgtctgtt ga
#aactttgg  92280
gatttaagag cttttgcacg actctgtttc cacagaccat tgtagtggta at
#tatgcctc  92340
tcagagacgt tattatttgg agtttaaaat taggggcaaa agaatcacca ta
#gactgata  92400
atcttaaaaa tgtttaagtt tagtgaaagg gactaatgaa agtacaagtg ag
#agatggcc  92460
aggtagaact tcactggatg gataagtatg agtctgtgga agagcagttt gc
#atttaggg  92520
aaacctttct ggcctgtagg gataaacagg gaagataacg tatgcattat tt
#taatccta  92580
aataaatact tgaaacttat ttgatttcgt ttttactcaa gattgagtat tg
#gcattttt  92640
attatcaaaa ttcacaaaaa accctcttaa actttttgaa aaaatcttcc ct
#aggcacat  92700
cagtttatgg aaagtgcttg taggcaatgt tttgattaca aggtttaatt at
#agagggat  92760
cctgtgattt gaaaaccaga cacccgtttc tgtaccttac agggctctca tt
#aaagctga  92820
acatgatgaa atcttaaacc ccatggcaaa ggcactctgt gattgttttc tt
#ttgtcata  92880
acacttctca tttaattact atgctaacaa tgaaaagttc caatgtgctc ac
#ttagattc  92940
agaaataggg agttgctatg tatcttttgc atccaaagga ttacttccct aa
#agtcacca  93000
gaggaacaga ggaagattgt attttgttaa cgagacagtg gtaatgtggt gg
#tgaacctc  93060
acatactctg tagtcaagac agacgtattt caggcaggct tggtatatat tg
#aatttatg  93120
agattgtggg ttagttactt aaaaaattat ttttaagttc tgaaatctta tt
#tctaaaat  93180
gagaatacta atactccatt ttagaagcta actaggagat taaatcagat ga
#ataaaatg  93240
gatgaataaa tatgaaatgt ttgttaataa agatacctgt cattgtttat gt
#accaagtc  93300
tttaaggggt tttacatata aactcatgca tcttcactgc aactctgtaa ca
#acacctcc  93360
tatttacata gcgccaattt ctaggtaaga agtttgaagc attgtgtttt tt
#actaactt  93420
gaccaagctt tttaaccatc ccaaaggtgg tggcagaacc tgctttcaga cc
#caggcagc  93480
gtgacctcag tcagtgctgt acttgtaacc actgcacaca ctacctgcaa at
#cactaagt  93540
ccccaagtag cccccagttc attactatgg gtgatgtttc tgctcccaca ac
#ctatcttt  93600
gctgtaccat tttctcttct tgatagtttt aattatttct agcagctctc tt
#ttctcaca  93660
ctttgtcttg gcttttgagg ttagtgttca cagataagca tgtgttgctt tt
#gtgtttag  93720
agatatggtt tctttttatt tttttaacac cgaataatgt gacttttctc ac
#accctagc  93780
aaacacttta ttagctacct ttaaattttt tcctgtctgt atggatgaaa at
#gatgttca  93840
tcccaatggg gtgttttaat ctatatgttt aaaattttat tgaatattga ca
#aattatac  93900
acgtatatat ttatggggaa cagagtgatg ccatgatata tgtataccat gt
#gcaattat  93960
tgaatcaagt taattaacaa atccatcacc tcaagcactt atcatttatt cc
#tcctatct  94020
aactctattt cttgacttat ggaattgagt aacttttagt aaattatttg ct
#cagtgttt  94080
gaatacccta ggtgactagc actgggccaa aagagaagat gaactcccta ta
#ctttagtc  94140
ctgttataag aactcaattt ttataataat aataataata ataataataa ta
#ataataaa  94200
gaaggaggaa gaggaggagg aggaggaagg ggaggaggag aagaaggaga gg
#gagaaata  94260
aggaggaaaa gactttccat tttatatgca tctttatcag gagccaggca tt
#gtactatg  94320
agctttatat ctaattgaat tcaagtttct ccttagagaa taggcttaaa aa
#cagactta  94380
aaaagttgga tacatatgct gaatttaaat aatgataact tcagtcagaa ga
#taatactt  94440
atgaaaaatt agtgctttag aattatgatt tgccaaatta tagtagtaca at
#ttattatg  94500
taaacagacc aatttaatgt gatttgtcac aggattttaa gtctagtcag aa
#atgacttg  94560
cacctactac aaaaagaaac atgtttatat ttttaagtaa aagaattcca tt
#ttctatta  94620
aaggatttgg agaagtgaca tcattctcta ctgttaatgc tctgtgggtc ca
#tgcataac  94680
agtgaatcag aaagtgtact tgataatcag ggaacatttt gtcctctctt ag
#tgacactt  94740
ttgtaattca tgtgcccaaa ggattacata ttgtttatta atatattata tg
#tcatttcc  94800
tcatttggcc agtgctttga aatggtaatc taatctaaaa aaaatttttt gt
#gtggtcta  94860
tgagaacatt tttttcccac tgagttctaa ggcccagtga ttcattatta cc
#taataaag  94920
aggattcttt attcatcttc atgcctcctt tcccaagcat atccaattag ag
#tcaccatg  94980
tgaaaattca taaatcaaac cgttcgtatt ttaatgtata aaaaaatgta cc
#taaaatac  95040
tttaggtgat acatgctgct ttctcatttt ttaaatttag caggagattc ta
#gcagacca  95100
tgaagtgctg ataactgttt taaattcagt atttattcaa atccaccatg ca
#ggatagcc  95160
acaggaactc ttttatattg gtaacattac ataagtacca atacaggaca aa
#aagatgaa  95220
gcattaatac gtgcctattt tacacattgg taacctattt tgtcacttga ct
#gtaatact  95280
ttgtgcagta aaattataaa ttatgtaact taaaattgat tacaattata at
#tagtagtt  95340
gtgcttaata atttttatat tcttatttgg ttcaatgcct gatcttcaaa ca
#cgaacatt  95400
tttaatcttt ttcaaaatca atatatttgt tcattagtaa atttagcaaa ta
#tttattta  95460
atatttactc tgtgcccagt acatctctca gaccgtggaa tagttttgta ta
#aaacaaaa  95520
acccctgtac tcaagggggc ttacattctg gaggaaagga cagagaataa at
#agtaagaa  95580
taataaataa gtgatttata tgttaaaata agataaagtt atggaggaaa aa
#agtagaac  95640
agagggaaga aggaggggga ggaggaggca gaaaatgcag ggagttgtgt ct
#ttcaattt  95700
taaatagtgt gctgtgttag tctgctcagg ctgccatcac aaaatatcat ag
#atggggtg  95760
tgttaaacaa tagaagttta tttcctcaca gtccagaagg ctagaaatct ag
#gatcaagt  95820
ttcctgccca tttggtatca ggtgagggct ctctttctgg cttacagatg gt
#tgccttct  95880
tgcagtgttc ttacatggcc tttccttggt gcatggatgg agatagagaa aa
#tatggtgg  95940
ggggaggagg aggagaaagg agtgagtggc acacacacac acacacacac ag
#agagagag  96000
aaagagagag agagagatgg agaacaagct ctctgtgtct cttcttataa gt
#cactaatc  96060
ccatcagatc ggggcctcac cctatggcct catttaactg taattccttt ct
#tactccaa  96120
atacagccac actggggatt agggcttcaa catattaatt tgggggaaac ac
#atgtattc  96180
agcccataat atatgatcat tgagaaggta tttcagcaaa cctttaaagg aa
#gtgaagtg  96240
gctacccaga aagatataca aggcatacac acctttgcag gcagaggaag aa
#gctgctgc  96300
aaaagccatg tgtcaacaat ggccttgtgt tattcatcaa taaggaggct aa
#tctggctc  96360
cctaggagtg agcaagcaag gtggggactg gaagggaaat cagaggggta ac
#aggggacc  96420
agacagttaa tgagggacca gatcacacat gccactggaa ggatatgggc tt
#ttctcagt  96480
gggagatgag gaggatttta agcagagaaa taatgtttta aaacgattgt cc
#ttgcttgt  96540
atgttgaaaa taggtggaac aaggacaaag gtggatacag gcagacttgc ta
#agttttta  96600
attcatgcaa gacaggatgg tggcctagat cagattatca gcagcaaagg tg
#gagcaaag  96660
tgaatggaac atacataaaa ctagaaaaaa tggtgtcatg aacccccaaa ta
#cctactaa  96720
ctcaatttaa taataattaa catttggcca catttgtttt atttagacat tg
#ttcactta  96780
tttctgaagt aaagtaagtc acataacgca tattccactc ctaaatactt ta
#gtatgttt  96840
ctctaataag tacattttta ttatattgct gtgattaaac ttaacaataa at
#tattgata  96900
ttatttaagc tacttgtata tacgttttca aatcagtctt tgattttttt ct
#ttaaagtt  96960
aatttatttg aatcaggatc caaataggaa tttacacatt atctttgatt gt
#tctgtttc  97020
ttctattatt tttttaaaga gccttctttt ctcctttcct tcccccctat gt
#catagact  97080
ccctgaagca atcagatagg ttgtcacgta ggaagtccca tattttggat ct
#gtctggtg  97140
gttttctctt gatgtccttt aatttttttt ctttccacca ctttcttata aa
#ttagaaat  97200
aagatctaaa gctttgagta ttcgcagtca acatttttgt cagaagtact tt
#ataggtct  97260
tgctcactag atcaaaatac cttccatcag gaagtgtaga atatctgatt gt
#tacacgtg  97320
atgctaaaat tgatcagtag gcttggtggc agcaacagca tgatccttca tt
#ggaaagtt  97380
ggttttgacc acttataaca agcgtataat ctatacagcg atattttgtc at
#cctgtaaa  97440
tgtccaattc cccattaact ttcctcctaa tcattttaga atacatttat gt
#ttgttacc  97500
tgaatcaact atttcgttag aaatactgat tattaatttt tttttatttt ga
#gctggtgt  97560
tttgctcttg ttacccaggc tggagtgcag tggcacgatg tcggctcact gc
#aacctcca  97620
ccttccgatt tcaagctatt ctcctgcctc agcctaccga gtagctggga tt
#acaggcgc  97680
ctgccaccac gcccagctaa tttttgtatt tttagtagag acggggtttc ac
#catgttgg  97740
ccaggttgtc tcgaactcct aaccttggga tctgcctgcc tcggcttccc aa
#agtgctgg  97800
gattataggc atgagccacc gtgcccagcc ctgtttatta atttctaatt tt
#gtcactcc  97860
tttaacattt atgcagcaaa attatcttct aataatgagc tttatctcct ta
#actagggc  97920
tatttttaaa aagtcataaa atgtagttca gataagaaac cnnnnnnnnn nn
#nnnnnnnn  97980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn natttttgtt atttgtattt ct
#tttattaa  98040
ataatcttat tttttatttc tgatcaattt ccatttttat taaatataag gc
#ttgaattc  98100
ttccctcttt ggccagtagg agccccttca ggaggatcat ttgttccttt ta
#taccagta  98160
gccttttgtt agcttcctag atctctagca ccattatatg tcttgaattt gt
#ttagttcc  98220
ttcctcccac tttgcaatta ccatctttcc aaagttacat agtttctttg gt
#gaaaatta  98280
caaatatgtt gaagatagag cctacaggat ttcctcacat gttttggatg ta
#ttctatga  98340
aagagagtca aagatgactc cagggttttg gccttagcaa ctacagtaat gg
#agtgtcca  98400
tcaactgaga ggtgggagga tacagttgaa aggagggaag tgtacatgtt ca
#gttttgga  98460
catatcaatt taacatttta agtatacttc aaaataaaga cgtctggtag gc
#agttagat  98520
atataagtct gaagtctggt ggataaaaac taagtagtca tcatcatata ga
#tgaaatta  98580
aaactgtgag gctagatggg ctcacactgg ggagtgagtt tagatagaaa aa
#gcaagaag  98640
acccgggact gagccccaaa gttaaaaaat ctaggagaag aggaacaaac aa
#gctgctac  98700
attttactag tattcttcag caaagaatat tttcttatgc caagataata tt
#ttttggta  98760
gtttgggatt caaaataaga ttccataata atatttaatg atcctgttat cc
#ctcttctc  98820
caggggaagg actttcagaa agaaccgtag agatcattct ttccgtcact tt
#gtgtatcc  98880
tttcaataat tctccttgga acagctattt ttgcatttgc aaggtaagat tt
#atttgcgc  98940
ttacattcca ggatgcttta tgggcattat atcagtcata gtccaatcag ga
#gacagaag  99000
ccacaacagt tacttgaatg ggaaacattt ttatttttaa tagacagata aa
#aatgtatt  99060
tatcatgtac aatatgatac tttaaagtgt atatgcgttg tgtagtgact aa
#atctagcc  99120
ataaaaggaa agaaatcctg ccatttgaac agaaaacatt taatgtaaag aa
#ttgttaac  99180
tagcagaaat ggctaactac taaagagagt aaaagagaaa tctaagagtc ca
#gaagtagc  99240
aagcaaaaca aagcagctac tctctttaac ttgaaggaga gaggacagta aa
#caactaag  99300
aactgaaaga agttgtctcc caagacttac atggaatcgc tacttctagc ac
#atgcaacc  99360
tatcaccaaa cagtgagcaa agaaatatga cagagggaag gggttggagc tg
#ttccgtag  99420
aagctacccg tcattattag atggtaggca ggctgaaatt ggtaatagaa gc
#atcccatt  99480
cttgctgaat ggtgtaggtg agctggtact acttgagact gttcacgaat gg
#catgggca  99540
gaacgttcac ttcagaggca acaagagctc atccaagtga gctgctgggc tc
#tcacaatg  99600
aataacaata atgcaggatt ggatcccaca agggcagtgt tttcctcttc ct
#actgcctc  99660
tcagggtcac tctagtgccc tctattgaca aagcctcact ttcggccggc tg
#gcaaagga  99720
gaaatgcagg ttccagctcc aatatcaaag agcacagcaa aaaaaaggag gt
#ttggagat  99780
gagagacaac aaggtgaaaa cacaaaagca gaagctttca ggccacctac at
#cttttaaa  99840
gtaatttgta actcttatag gtttaattta aaatatctca atcaggtcta aa
#tattaaag  99900
tttatacaga aagagatctt ttttatagtt agaacaacac ttgtaaaata tc
#cagcttcc  99960
ttatatggta gacccccttc tcatgcttac tttctgaaca tgtctgtgct ga
#attttcca 100020
agtgtatctt tccattctca gcatcagcat cctacttccc ttattattta ca
#gggcctcg 100080
ttggaaatct tacttctgac ctcaaaatct agcttcttaa ggcagattgc cg
#agttaaag 100140
ggaccttaca tttgtaaagt aaactttcta ccaatttcct aaatagttca at
#agactatt 100200
tttatttcaa ctgaagaatg tagttctgta ttctaaatgc catgcattat gg
#ttcatctt 100260
gactctctta aagcataatt ttaatagata atttgaaagg ctcttgaaaa ag
#atattttc 100320
tctataccac ataactattt gcagatttag ccagaagaca gtgagagagt ta
#tcattcga 100380
ggcactttga atgctataat gtgtaaaata tgggcctttc cctaaggagt at
#ggactggc 100440
cacatttatg taatttccct gctctaaaat cttttctgac ttctcatttc tc
#tacaagat 100500
gaactccttg tgtgagtagg aaatggtcct ccttattccc cacaacttgc ct
#actcacta 100560
gctaaagaga tctattctca cctgaacatt ccttgggctt ttatacattc tg
#cttttgtt 100620
cagtcaccct gaaatgtgct tcctcctcct tctcatcctg ggacatccaa gt
#caaattct 100680
acttctttac ctcctctaaa taataataac tatttatgta actaatcagg ca
#ctgtctta 100740
tgtgttgtaa tttgaatctt tttttctctt ttcatgtttt ttctgcattg aa
#atcttgcc 100800
tctcaactaa attgtaatgt ctttgagggt agggaacatg ttttatactt tc
#catatcat 100860
ccttgatgtc caactcttaa taaatactaa atatttgaaa tgtgaaagat ag
#aatagcta 100920
aacattactt tgtaatatac catactgtgt catggagaaa taagcattta aa
#gggtttaa 100980
gatgaaaaga atctgatttg attctcagat tcatgtggct tttatttttg aa
#cctaagtt 101040
ttctgattgt aaagataata tctactcaca atatttttat aaaaattcaa ta
#agataatt 101100
tgaaaataat ttttaagtat tttcatgcat gtaaaaatat ttcatatatg tg
#aacacaat 101160
ggggcattat ctgttagcaa tactattgat agcattgaac tattttcact tt
#ggcatagt 101220
tcctttatat gacaaatcaa tgacatagct agagagaaga gaaacaagat ca
#caacgtaa 101280
gtcttcttgg ctctatattt aaatgtacca atggctcagg ccttcgtcaa ct
#aattcttc 101340
ttaaatttag aacttcatcc caataactta ttagaaaaaa aagaaagtag aa
#taggttct 101400
atggaattaa aacaagaaaa agaagtcgag tagctataaa tttgcaacat at
#tcagagag 101460
gtgattttaa caaggaaatt atttgactaa atgtctttac ttaaaaagaa aa
#ctaaacct 101520
aattttatat actttgtgtg aaactccctt cttggacttt actccgcttg tt
#ttagaatt 101580
cgacagaagc agaaagaagg tggcacatac tctcctcagg atgcagaaat ta
#ttgacact 101640
aaattgaagc tggatcagct catcacagtg gcagacctgg aactgaagga cg
#agagatta 101700
acgcggtgag cacactcctc tgggtgaact gtggtccaga gggcctggag cc
#atgaccct 101760
attctgacct atgcttgttg gaagtgtttg tggggctcta atttacacag gt
#cacagaga 101820
tcttctttca aagagtgacc tccgtcttct acacacttct cactgctgtt ca
#gagaatca 101880
cttaatcttc ctaatatttt gagttaaata tgaactttgg actataatgt tc
#aatcagga 101940
ttattttcct gggacaaata tttttccaca ttaaaccttt gacattatgt tt
#aataattc 102000
atttcatatg atagattttt acattaaact tttctggaag tgtccacatt tt
#caatcaca 102060
ggtttaaatt aattaaattt ataactactt gatattattt atatccattt tt
#ataaaagc 102120
tttttaataa ctatttcagt ataaaagtac ataaaagtct aagttgtata tg
#atatcatt 102180
tttacatttc tttgtattta aaaattaaat ataaagtaaa aagttacctt ca
#gagggaaa 102240
agtaaaaaca tgtgtactaa atatgtttca ttggtaccta ttggaaatag ta
#aagtacat 102300
aattttaaag aaaaaataat tataaatcct tttaaaagca ttatcaatta tt
#caaaatgt 102360
tggcacatta taaaaacttg tctattaaga taattcatca aattcttaat ga
#aaactacc 102420
atcaggctat tttaacgttt gcatttttat aagattcaat aacatgtaat gc
#ttataagc 102480
acaaagtagt tgttaccaag tatttgctca gctctgttaa aattaaaaaa at
#tattatta 102540
attttgaaaa tatggcatca aatgtcttgg actcaaaaag ttattcattt gt
#agttgtca 102600
cttgttaaag ttggtcttta tctaatagat ggactttgca agtatatttc ca
#gcatatct 102660
aaaaatacct aatatgtgct atagagggaa gtgtcatctg ataagcaaag tc
#cttccaaa 102720
tgctacaaaa tgaaggttat tcaatgttat cactaaattg cagggaaatg tg
#ttttcttg 102780
gatatgacag ctgacttttt aaacattcag atgttgatct ttgtgttcta at
#acagtggt 102840
cctatccaca aatggatagt actccaaaga tttaagtgtc agatgattgt aa
#gttatcca 102900
agacatagtt ttctatataa gaaatattat gtacaaaata tcaaatatgt aa
#aaagaatc 102960
aataaaagat tcccagggta actcatctaa gtaaaaccat atcataggaa ca
#caagcact 103020
gctactacta gactgtgtct cagcccttaa ggaatcattc tgcatcatca aa
#gaaagttt 103080
ttcctccttt tcccctatgg gccaaatgaa ttttagtggt atcctcctag cc
#tccttcct 103140
gcactccatc gtcagttcct tttgcccctc ctcaggcctg tgtggcccat cc
#ctttattc 103200
tacaactgaa aatgcacaag ggaaaaaatt caaatctctc aatgcaatta at
#tttagcta 103260
tttgaacaat atagttgaat ctgttcatac taaaatgtaa acttctaaga cc
#gaccccct 103320
ccccaacact ggtaggcatt ttcattttgt taaaagaata cttagtagcc cg
#tgaaaaat 103380
cctgaataag tatatcttca gcaaatgtaa taacgtgaaa aagcactctt tt
#tgtttatt 103440
atgtcatgtt tttaaacagt caatattgga gaaagtatta tttatcgaag ag
#gttacatt 103500
cgaggcagac tgtggtgaga ttcaatcccc taagcactat atattttcac ag
#cttgcccc 103560
tttctctact tctgaacact aaatacatca tcataaaaaa attagaaaag gt
#cgggtgtg 103620
gtgactcatg cctgtaatcc cagcactttg ggaggctgtg gagggtgaat aa
#cctgaggt 103680
caggagtttg aaaccagcct ggctagcatg gtgaaacccc atctctatta aa
#aatttaaa 103740
attagcccag catggtggca tgtgcctgta gtcccagcta ctccagcctg gg
#tgacagag 103800
cgagactcca tgtcaaacaa aaagagtaga tttttttttt ttaagaatga ct
#gtcatggc 103860
agctacagaa aagtttcaga tcatgaaaaa ggtgggcaag gaatgtatag at
#tgtttact 103920
attggttatt tataattcag ggtctacttt atttgacctt cactcttcat ta
#tttatttt 103980
tccacttctg tgtttattta catattgcat tatttgtaaa agggtttaaa ag
#tgaaataa 104040
tatttcagat aatttttatt ttgttacaca cagagaatta gtatatatta cc
#catgataa 104100
tagcaaaatt ggaaatatta gtttccatgc ttttcacttt ttcacttgtt tg
#ttgtgatt 104160
ctggtattca caattgtttg taattccaat ggcacataat aacatgcttt gc
#tggactta 104220
ttacagaaat gcattaaaat aacaattaag tgatttgggc attaattctt ca
#gtacagag 104280
atctgtgtcc agctttacta tttatgcaat atttttatgt taataaagtc ac
#taaaacat 104340
tagacaataa gactggaaaa aataacaaat ataattagct gcatgtacat at
#gcgtggat 104400
cctgtcattt ggtgaagctc taaaactctt catctgtttt gaggtgtttg aa
#gatctaaa 104460
tctgttcaaa gtcaatcaga gactgatggt agattctagg agtgagaatc aa
#gaagtctg 104520
atttagctcc ctaaattgtt ggcagacttc caccatatgt ctttgttatc tg
#caggaaag 104580
aacttccata atttctctta aatctaccca gctaataggc tgggcatagt gg
#ctcatgcc 104640
tgtaatctca gcactttggg aggcctaggt gggtggatca cctgaggtca gg
#attttgag 104700
accagccggc ccaacatggt gaaaccccat ctctactaaa aatacaaaaa tt
#agccaggc 104760
atggtggcgc atgcctgtaa tcccagctac tcaggaggct gaggcaggag aa
#tcacttga 104820
acccaggagg ctgaaagtgg cagtgagcca agatcacacc attgcactcc ag
#cctgggca 104880
acaagagtga aactccgtta aaaaaaaaaa aaaaaaatct acccagctaa ca
#tacgctct 104940
ctctacttga ttcttaggca tgtccttttt attccaacct gctaaatttt tc
#atgcaaaa 105000
ttgagctcat aacttttctg agtcctgtat gttttcccat gtccaaaaga ta
#aatgataa 105060
aagaagaatc tctaatcaat aattaaaata ttaattttag gaagttacca ac
#taggcaaa 105120
aataaaacaa aaaacaaaca tggtgcttgg tactaagtcc tttcaatgat tt
#gtggtttc 105180
atattttaga aattatttaa ctattttata ctctctgcct gtatatttac ac
#tttaaaac 105240
ccattctgta atttttgtta tttgtaaact cattatttaa ttatgctcca ct
#ttgtttca 105300
caaaactttt gaaaatgcct tctctcactc tatcattcta tactatttct tc
#ccaaatga 105360
gagcaggagt caaataaaga tgtagtactc tttaattcta tgaaaacatt ca
#aggatata 105420
ctaaaataac gttttaaatt ctcaatttga atgataatta tattatgtac aa
#agattatt 105480
cacattttat gtttaagttt agataacaca aactataatt cttaggaaga at
#atgtaaca 105540
ttttgggctc atctgtttca cacttaccga attaggaaat gatccttggg tt
#ttgttatc 105600
taataaacat acagaacaac attttgtgat ggctcctgca aaacaccacc ac
#ttagccca 105660
ctgaagttag aaaggtttct tagagctctt attggcaaga tcagcagaca ca
#gacacgca 105720
cagtaagaca cagacctgta tcactgagac tgactcacct tgtggattgc ct
#ttaactac 105780
tttaactgta caacgattac cttcccatga gagtcacatc acttataatt aa
#ataaccca 105840
acagaatttt cgtaagctaa aaatgctatt tgctaaataa gcttattttt ta
#ctatcttc 105900
tttccgcatt taagtcacgg aagttttgtt tcttatgccg actaaatcag aa
#aagaatag 105960
taaaacaaca ttaatcaatg tcactaatat tcttacttga cagaaactca gt
#ttctttta 106020
gtcctcaatt ttttttcaaa aattttatgc accacttcat attaattacc ct
#gcctattt 106080
tagttgagtg aatgtaatgg cacattattt taagcctcaa agcccaatcc aa
#taatcacg 106140
aatagaatta aaattcacaa gataaagtaa acaatctaat gagttggaaa aa
#tttctatt 106200
ttaagagaag tcttcttcaa taattttctt tcttcagtaa cttcagaagt gt
#acatgttg 106260
aatttttgtt aaatacacag ttatgtcttc aggaagatta ctgcttaaaa aa
#attctaca 106320
tatgtacttt gtaaactgta aaccagaata cctttggtat tgttactatt gt
#gatttata 106380
tttgtaatat tgaatactac cccggtctac tttcatatat agagtttgct aa
#caaaataa 106440
tagctactgt ttatgagcaa ctcctgtgtt aaactctgca tgtagtgatt tc
#acttaact 106500
ctttcaaacc ttagtggtag gtacacctat ccccatttta cagatggatt aa
#aaaatgat 106560
gataggacag gtttatgtaa atgtctaagg tcatacagct aataagcagg ag
#agctacaa 106620
gctagcccag gtctttctct gaggtatgaa gatacacgtg tgtgtgtgtg tg
#tgtgtgtg 106680
tgtgtgtgtg tgtgtgtgtg tttaacttcg aagcatacta gagaagatta at
#gtaaactt 106740
ttcttaaata gacaaagacc catggaattc ttcctcagca gcattttcta tg
#atgagaat 106800
gagtctaaag aaagaggttc ctctttggat ttctttgttg tctcatgata tg
#aagcaaag 106860
aagtgatggc atttaatgtt gactcaaact tgcaggaact ggaaaacttt ta
#gtagtgta 106920
atttttattt tggcttcaat aataactcat aatttttgac tgatatatga aa
#ttctaata 106980
gttcacattt taagtgtcat cattctttga caaattctgt tcatatattt ta
#cttccgtt 107040
ctaaacttaa gctatctttg caaacaatgg caaaaatttg tgaattcgga at
#acaagaaa 107100
tgttctatgc ttagaatgaa attggagata cttaatgctc atattcttgt aa
#taacaaat 107160
caaaaataat tcagtgtgtt tgtatactaa ataatgaatc tttacttgca ga
#tactcttc 107220
atttttcttt agacgcaagg agatttttgt catccagtaa gttactgtgg ta
#atgcagaa 107280
ctctgctgtg attattttaa tcttgtcagg tggtgtgctc tatattttaa aa
#tacataat 107340
attgaacatc ttgttgttta atgcactatt ttttccaaag ctccccccaa aa
#gctatatt 107400
tctatttaca acatgtcctt tataatattg catgctattg ataatggtca ag
#ttaatctt 107460
atcaaaatgc acattgactc ataatgtgca tgtcctgaga atttgctgtg tt
#ctcatgtt 107520
gtgttagatt tgatagcaaa ttaagtttgc acctagattc ctgtacaggc tt
#ctcattct 107580
gttatcaaca tgacgcaaga gttgagctct acatctgatg ggtggaaact at
#atttacat 107640
ttcatacaag ctcatttttg caactgtaga tggttaacct gtaaggacca ag
#acaatgac 107700
atttcttgtt ccctgactct ctagtgcata cacagaatgg catatttcat gg
#aaacgtta 107760
tttctccact gaccaatggg tagccaactg tgcacgcttc caggcactcc cc
#tgatgctc 107820
agaaatgcca tttgtatcct ggcacaaaca ttttttgtta cattctgaga gt
#agcatagc 107880
agaatatcag cactagcagg gaccccagta actgattgag cgtcccaaac at
#aataaatt 107940
tcttcatgca aagaatgtaa atgaaggaat atgaatggag gcagagaata aa
#aaggcatt 108000
tgatttcaaa atcacacgcc ttactaaaga agaatccgtc ttcatgagct at
#aaggctga 108060
atggggccaa agctcctgat agtctggtta accatgaata atactctgca tt
#attaaaat 108120
caaggaagcc cggtctattt ctaatctaat cacatttagc atttgggaat ca
#taagtaac 108180
cttgttttaa cttcagatta actagttacc aagttcccat tgacagaatt aa
#aatacttt 108240
aatgaaaata catttccttc agaggacctg cttgatgggg ttcaaacatt tg
#tcaaagta 108300
agacactgtt aaactgaaga tttaattgat cacattacac ataaaatatc aa
#ttttcaac 108360
cagcactcaa agttaacctc tgggccattc cagactcaga ggcggtttgg tt
#gagcaact 108420
ctgctgaatg tctttcttca tcatcataaa atagaatcct tttcctattc tt
#tttctcct 108480
tctctctttc tctctctctc actctctctc tctctctctt gctctctctc tc
#tcgctctc 108540
tctctttctc tccctccttc cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 108600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 108660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 108720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 108780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 108840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntattcatt gagtcccttg ct
#cagggccc 108900
catccatctc ttcacataac tttgatcagt ctctttctcc tctctatcta ca
#aattctac 108960
cctgttgccc cggatgtagc taaacaatgc ccatggtttt catttagaat ac
#atggttga 109020
caaaagaaga cttctggcaa gaatatttct tcaaatgtgc taatgtggaa ag
#gcttagta 109080
ataaggaaaa ttcaacttct gccacactgg ggatcatacc tctgagcttt tt
#gacatcag 109140
caagaatatt gcattcactt ctcatctaaa aggccatttc atcttgttta aa
#taaaaata 109200
aataacaatt gagggccggg cgcggtggct cacgcctgta atcccagcac tt
#tgggaggc 109260
cgaggcgggc ggatcacgag gtcaggagat cgagaccatc ccggctaaaa cg
#gtgaaacc 109320
ccgtctctac taaaaataca aaaaattagc cgggcgtagt ggcgggcgcc tg
#tagtccca 109380
gctactcggg aggctgaggc aggagaatgg cgtgaacccg ggaggcggag ct
#tgcagtga 109440
gccgagatcc cgccactgca ctccagcctg ggcgacagag cgagactccg tc
#ttaaaaaa 109500
aaaaaaaaaa aaaaaaaaaa ccaattgagt atctctcaag tgctaggcac tg
#ttttaggc 109560
actgggaata gtgtgatgag aaaggaagaa acattgcctc caaagagcta tc
#cttcaaat 109620
ttaatgcttc ttttaaactg atttgtccta cacatatgag aagatatgtt ga
#gaaggtaa 109680
tacatatcat ttactattaa ttgttttcct gatttaaaaa agtattacat gg
#ccaggcgc 109740
ggtggctcat gcctgtaatc ccagcacttt gggaggtcga ggcgggtaga tc
#ccctgagg 109800
tcaggagttc gagaccagcc tggccaacat ggcaaaatcc cgtctctact aa
#aagtacaa 109860
aaattagcca ggcatagtgg cagacacctg taatcccagc tactcaggag gc
#tgaggcag 109920
gagaatcgct tgaacccagg aggcagaggt tgcaatgagc cgagtttgca cc
#attgcact 109980
ccagcctggg caacaatcgt gaaatcccat ctcaaaaaaa aaaaaaagga ag
#tattctat 110040
tactcactta tggtatattt ctcttataaa attttagaat cagctgtata gg
#accaacca 110100
tgggttagga tattttaaat ttatattgag caccacggaa acatcaatga tt
#tggtaaaa 110160
gaatacagaa ggatgtgaca gaatgcagaa ggatgtgaaa gaatgcagaa gg
#atgtgaaa 110220
gaacaaaata aagaaaacta ataggaaata acaaaaatta aggcaccttt aa
#aagtatta 110280
aaatagatgc tttggataag cgatagaata ttgtagaagt agatgtaatt ta
#tgtgtcat 110340
tagtgacttg atgaaatata taaactaaaa actcacactc agtatcatac aa
#aacttgga 110400
aatattaata ttgtaccaga gaaatagatt cttcacaaat ttaatctaag ta
#gcaagtac 110460
atgctatggg atacaaatac atatttttac accaattgac aaatttgaga tt
#cttttatt 110520
tttaacttaa catcactggt taagtagaag aaaagtttct cagtttgtcc ca
#taccactg 110580
gtaatgctgg ttgaagctgc tcagctatag gttatcatct gtggctctct at
#taggacta 110640
tattttaatt ccctatagat ttcaactaat tgaccttgag ggaaagctga gt
#ctctgtga 110700
caatatggtc ttcaatcacc actgccaaca taaataaatg cttcctttct ag
#atccatca 110760
agagtaatct gagtggaatt taagtttttg ataggcttta aagaaatgag tc
#cagacgtg 110820
aaataagaca cttttcaacc aaaaggatat agaatttaag acagttaaga tt
#cgtgtaat 110880
aaaaagtgtt tagccctttc tattggaaat tagtcagtta tcttattgaa at
#ctggacag 110940
ttcccaaatt gatttatcca gtaatgaact gattatagtc tgacagtaac ct
#tcactatc 111000
ataaatgaat atcctaccag tctaaaaatg ctttccattt aacagttttt tt
#ttaagttt 111060
ttaaaatgtt aataaaaagt tttctatttg agtatgtttg agtatctcct tg
#gatcactt 111120
cattcgaaac tagcactcct gaaatagcat tgttgatttt catgcacatc aa
#tttctgtg 111180
agtttctagt gcttatttaa gcaaacagtt tttcctatta ggaatttaat ta
#tacctctc 111240
agtgataagt tagtgcattt tccttatagt atgtcccatt ttcttttcta at
#tctctcta 111300
taaatcagtc aaattaattt ttttgtatat aaacattaaa gcttaaaacc tc
#aaagaaaa 111360
atacaattta gaatgtagcc aacacctaag ggagaaatac acctatacaa ca
#tgaggcta 111420
agaacgaaag caatgataag tatactacag acaacaatga ggaaggaaat at
#ctaacttt 111480
tatttgaaat agtcaggtaa tgtacctcaa aatgtcttct caatttgagc at
#tcctaata 111540
ggtatttgaa gatttcaact cacaaatgat tgtgacataa gtacagacta ga
#aaattaca 111600
taaaaactgg actactagaa gctttcttat cttatataaa cataaatgtg aa
#gaacagat 111660
tctaaaaagt gattggattt agataaaaaa gagtgataca aaagaaaata aa
#gccaaatc 111720
agattccacc tctctttttc ttaaagtgtg tgcctatttg tttatcactt ga
#gtaggcaa 111780
gagcaatttt attgttcatt tatctaactt cctaacaaag tacacctgtt aa
#tttataac 111840
gttaggttat ctgctatggc ttttgcttag actcacatgc tttttgttga ta
#aatctatt 111900
gattatacgt atttaaagct ttgagttagg acctcttgag aattctcagt tt
#cttaataa 111960
tttagtgtga aaatgtattc aattcagata ttccctcaca ataaagccag aa
#tattcata 112020
ttttgctttc tgtgtatctt aatctgaatt catccacaat tttatatttg at
#atgtttta 112080
tttaatgttt actgtgaata atgttatgag ggacatctag taagccaagt gt
#taatcctg 112140
ccccagccct gaagtatata tgagcccaaa cacttgtatc cttaatgcag gg
#acttaaat 112200
agccataata caacatagaa gatgatttgt ccttggaaat ttgattttac ag
#gcaaagga 112260
aattattttc tttttagtag aacagagtaa gatcgatagg gttgttaaca tt
#tgaatcag 112320
gtattaaaga ataagtaaaa tttccgttgt acgaagaatg cctggaatgg ta
#taaaattg 112380
agagggaggg atatatagag aatatctgga gtgcaaacag gatgcatgaa ga
#ggagttac 112440
aaggaataat gtcagaaatg tgggcatggt tagaaatgtt ttacatgatt at
#atgaaaac 112500
tgaattatta tggtcattgt attagagatt tgtttgggat ctcgaattga ga
#gctagaaa 112560
tccagacttg gatttgaaag ctagatattc gtgactacta tattttagca ca
#atatagtc 112620
tatccatctt tgagtaaaat taagagaata ttcttttgga aataatggaa aa
#aatccctt 112680
ccttatatca gtatcaattg tagaacagta tggataggag cagcttgaga tg
#aacaaact 112740
aaattagcaa tagtaattat catactattg atagtaacca atacttatgt at
#tgcttact 112800
aaaggcagag acctttaaat atatgaactt aatttaatac atttcccaaa ct
#aggaaact 112860
gaggcacaga aaaattaagt attgcacatg ataatataac tagtaattgt tc
#aagcaggt 112920
atttgaaacc aataaaggca tcatattttc taataaggca ataattcaca aa
#tatccacc 112980
caaacccatt atagccagtt atggtttaaa atatctttag gcggacatca tg
#aaatgcac 113040
atctttatta tcccccttga ggggtgaggg agctggggta tttatccacc aa
#ctctggtt 113100
agtcattggt tgatggatgt ttcttggaat atttaccctc cgatgcttct ag
#cctggatg 113160
caggagacac tcgaggagag tggcaggtcc ttgtagtagg aaactatctc ct
#tgcatgcg 113220
aatgttgagt gcccaggcga tgtgggttag gcaccaatga catctgcaca aa
#cttttaaa 113280
aatctgaatt tcacagcact taataaattt acgatgatgt atttctgcga aa
#aaaaaaat 113340
ctttagggag agattttaaa tgcaaaatga attaagaata gtgaaacagc aa
#cttttggt 113400
agagtttttc actgaaaaga catgaactta aaacaaaaaa atgtatattt at
#tcaattaa 113460
tcataacttc tgaaatgaag aatagagatg attaaagaag agcaataata tg
#aataatat 113520
tttgctttag ctatttcttg ctcacttttc tttaatatga ttattcacat tt
#aatgtctc 113580
ttagggattt cacaaatgta tactgatgct tcaaatggtt tattgacatt tt
#cccagaaa 113640
ccaacatcta ctttagattc tagttatctc agtaaaaata cttttgcagt ac
#cggctcaa 113700
atgatcctct aggaaaaagg aatctctctg cgatgggtgg cagtctcact gt
#ccttatat 113760
aggtggacta ctagcctgtc actaaatcat atatattgtg cttaaatttt gc
#caatcaca 113820
atggaataat atttgctgtt attataaaag ttatttccac aaagttcaag ag
#tttctatg 113880
tccatgtggt agcagggaaa tagaccttgg taatcaaagc atctcagtca tt
#tatatctt 113940
aagttcagtt gatcagaatt tacccaacac aaccttctat tctttcctat tt
#ctgaagaa 114000
caaggtatca taggggcact gggcaacaag ttatcttaag ggagctaggt ag
#tatgtgtg 114060
gatgtagcct gtagtttatc tttctttctt gctggtcttc gctgaggggt aa
#ttattttt 114120
aacaaagatt gattgtggct tcagtcccca ctgcaactgt tactatgtca ga
#gatatttc 114180
cagggcctcc aatattcaga cattctattt tcccttcccc aaatcaaaga tt
#cttctcat 114240
ttggtagccc tttcagccat ctccatatcc atctagaata aggaattctt tc
#ttgctttc 114300
tttaaatcac tctagggtat tgtggggcac tcttaagctt atccaccaag ac
#tctttgtt 114360
agtcactgct actttgtcac ttagatgccc tgtttggcaa tggaatagtc ta
#tcacttta 114420
tgtttaccct gagaagctgg aagatacaac atctctttct gcttgggggg ca
#cccatcat 114480
taactgagaa ttctaacatt ctactttgta atacctggtc cagcatcccc at
#atttttca 114540
acaattcctg tattgtaatg aaatatactt ccttttaaat cctgttttct tc
#attgaata 114600
cacctctttt tgaccatttt catatttatt atgctctgtt tttcaaacca tt
#ttttttct 114660
tttattcatt ctttgcttca aaaaacatat cttcttacaa atattcttca at
#taaagaat 114720
atagtaaaat ccctaatatt attctagatt taaaactttg aaaaagtcat at
#gttcctta 114780
gttcatttca ttatattttg tgccttttgt gttttttgca gtgctaattt gt
#tgtgcatg 114840
acgtaagtgt tattaatgat acgcccctct ctaagtttgt gtatgttgtg ta
#gcctattt 114900
agctgttaaa attatttttg tttacagagt ataagtaatt tggccaatga tc
#tgtcacaa 114960
aagataggtc taaaataatg gaaatagtta taatttgttg ttgctgtgta tt
#tatccaaa 115020
ctcactcatg aaacaatact taaccaatgt gatgtcatgt ttcatggatt ca
#ttctgtct 115080
ggttcaacac tttctatata tagaggaaat atttttaaaa tccacattag ct
#cttttaga 115140
ccactaaata ccatgcaata tattaaaaag tgatctattt ttaatgtagt at
#cctaaatg 115200
cctaacattt ttaagcattt ataatgacat ttataataac aacaacatct tt
#tcagctcg 115260
agaaagaatg taaattattt gccatgtttg agtccaaata atgtaatttc aa
#aaaaataa 115320
ataaaattta aaataatgat catatattag ttaaaggcat agcacatttt ac
#attattga 115380
tttattataa ttttctgact ttaatctaca cttctttcag aattagctgt cc
#actctgac 115440
tcacaatgca tttaacacaa tctctattgc aggttactta gttatagaaa at
#ccatcaag 115500
taagtttgtt aaatattttc tttcttcttt ttgaatatca aagttagatg ca
#ctgactca 115560
gtagaacctt aatgtgtgat tcactttttg tatgtttgtt ggaaaaacct cc
#aagctgga 115620
tataaatcat aaaagcatga ctaattgcat ggtaactgga gaaatgcttt ct
#ctctctct 115680
ggggtgaagc ctgcatgtct gtattttagc ttgggaagta atacggggat at
#ttaaactc 115740
cttggggttt gaaaaccatg tcattatgag aatgaggtca ctgcaatatt tt
#atatcttc 115800
taaaaccttg taatgtataa aatgttttct gtctgacaaa gaggtattat gt
#gctttagg 115860
agtcaatgat aacttcatgc ccttacattt acttgaaaaa ttttcttcat ta
#aaatgcta 115920
aatcctttat ttaatgtcac taaaaaattg aaggaatttt gtgccatgaa ta
#caaagaaa 115980
gtgagcttaa agaagaaaag ttaattttat aagtataaca gagtgacttt aa
#aaagctgt 116040
gttgtttgtg attttgggga tgtccattgt tctttaactt gttaaaagtg aa
#gccagtgc 116100
caatgctaac gcgaacaaat acaatctaac atgaccctat tttatacctt tc
#tttacttg 116160
gaggccaata agcaagaaat ccttcctgca acatgttgaa gagctttgca ca
#aacaacaa 116220
cctaaagttt caagaagaat tttcggtatg ttactagcag ttgtcacaac at
#tgcaagac 116280
ctccagtcgt ttcatgtgtc acatttcatg tccattttaa gcaagcaagg cc
#atgaagga 116340
ctctggcctt gataatcaat acccaattac caggttgatt gttttgatag ta
#atgttaca 116400
ctgggccgcc tctggtgcaa cctgatcaga attattcacc tactgtgtca gg
#aaaaggtg 116460
gtcttcttca gacctcccct gtattggcag catgaccttg tctattctct gc
#tctttcat 116520
ccagatgtag gtgcaaatgt agaatgccat attcattagt ttgttttgta tt
#caaggttt 116580
aggtcatact ataagtgtag ttttatattt aagtaattat tttacatttg ga
#cactaaat 116640
tatttcattt tacgtttacc tacttggttt acattagtga tatagatgaa tg
#tgagatca 116700
aaacttgaag cttccagaaa ctataagaaa attatttcta gaactgtcta aa
#aataaaaa 116760
aaaagataag taatgtccac gttttacagg gggccttttt aaagttacta tg
#gaataaat 116820
gctgtatcat ataatgaaaa tgtataaaat taagaatttg tcactttaaa tc
#tacttaaa 116880
agttgggaat agtttttttt ttaacatttt gtatatctat aaaattgaaa tt
#atttaaaa 116940
acataaggta gatatcaaat cttcaagcta ctttaagagt tataagcatc tt
#ttctaact 117000
tagatgatta ttttgttatt aagaaagaca gatttctaca tgtcaccaaa aa
#cattattt 117060
ctattttatt tttttccatg aaatttccag tgtgtgaact cctgaaacaa ag
#aataaaac 117120
aattgggtta aataattcag aattataata tttcagtctc ttagggaata at
#aacaaaaa 117180
tgagagaaga ttaatggtat ttcctgcagc cttttggtta tgcttcttaa ga
#aatattgg 117240
tctggactta acaaaatcaa tagtgccata aaattcttcc tagcatttag ac
#agcaagaa 117300
ttctcaattt ttcaggagca aaagtgtaat ttccctagaa taagagtgaa tg
#taattaca 117360
ttatgcatga ccaagtagat aaaaagtttt attagcaata acattttcac at
#atatgaga 117420
aagtttctag tttaagtttt ttgaagacca tagtttgaag aactttttaa aa
#atttcatt 117480
ttgtctaatg ctttgttaag aatttctaaa gcaaattatt aaattatgtt tt
#aataaata 117540
catttttggt gcatatattt gataaacctt ttaactcagg acatattcac tc
#atatctta 117600
aatatttata agttcctact atgtgatagg cattgtattt ggcacataca at
#cagcactt 117660
accagctaag tgactttggg caaatttctt aaactctctt tgcctcaata tc
#ttcatttg 117720
taaaattata atatctactt tattaaatta tgaatataaa atgattgaat at
#aagcaata 117780
ctaagaacag tagctggcac aagtattagc tattacgatg ataaattcta cc
#ataaagaa 117840
gctcatatta tggtaagaac tgcagatgtg taaaaattgc aaatttactg ta
#tcttgatg 117900
gagatatgca tgaagattga ggatcaaatc tgtttgtata tcaaccagaa aa
#gagtttat 117960
aaaaaaggtg tctttcagga tgaactttag gatgagcaga agtctaatga ga
#aggtaaag 118020
gaaaaaaggt gttccagaga caggaaaagg ataggaatgc aaaaacggtc ta
#actcatct 118080
gtggtcccac tgaaaagaga gaaagcaata ggagaaagag ctaaataggg ag
#aattgtgg 118140
ccttgtgcac cctgataagg ataacactgc ccagtgtaac attaccatct aa
#acaatcaa 118200
cctagtgttt gagcattgct taccaaagcc agagctgctt aagtctagaa at
#ggaaactt 118260
ttatgtgaaa taattataaa atataagtgc tctttcagtc tatttaaact ca
#cctttttt 118320
ctcccttctt tatgtatttc caaaactttg acacaaggaa gctgttctag ga
#ctccttat 118380
tgggttaaaa aaattttgta agcctttggt gccaacacat cagaattcag at
#cttacacc 118440
attcctgtcc cttaatacat acccatatgt aaacaattgt ccagatttta at
#tttgagaa 118500
aaaaaaataa gaaagggaaa cttatccaat taaaagaaat aatttatatt ga
#tgttgaaa 118560
aattgttaaa acacatattt ttagtgcttt ttatggaatt tggcaagttg ag
#atttctaa 118620
aatggaaaac tataaatttc acacatgtaa attttcagct caacaaaata at
#gaacatat 118680
tttcttatgc cagacttttt aatgatgctt gctttgccaa gagcaaggta ga
#tagataat 118740
atcataaatt ttcatcaaat gtcaataata gatcttcttg acccttcatc ta
#tatctgat 118800
aattcttaat tgcacctttg cattccatta ttgatttagc aatgcttatt aa
#gagcagga 118860
attgacctct ggcatcttct caaactgacc aatgttgtac caattaatag gc
#atgaaatc 118920
acactgcctg aggagagaaa acaaaaaata aatcattgaa atcccttttc ct
#actaagta 118980
gacattaaaa tattaaacaa tagtgtgtac ctgatgaaac cattagtaac at
#atgtaaaa 119040
tggtcactaa catggttgcc acatcttaag gcttcccaaa gtgcaaagaa at
#tatctccg 119100
aaagagcaaa acccagctga ccaactttat tcaggatatt tttggtgaaa gc
#ctaggtaa 119160
actcattact gttaacttga ccttgtttcc acagttatga taggtgtttt ta
#atttaaaa 119220
attaaaaaaa aagtttagga caaataactg tcttttaata agtgaaattt ct
#tgtttacc 119280
tctgataaat gtaaactttg taatgacttt attttacagg aattaccaaa at
#ttcttcag 119340
gatctttctt caactgatgc tgatctgcct tggaatagag caaaaaaccg ct
#tcccaaac 119400
ataaaaccat gtatgtgcat ttgttggttt tggtttagct aggaaatatt tt
#taaatgcc 119460
taccatctta acttttttgt ttccttaata tattttattt tatattgttt ga
#attataat 119520
aatgtatttt attggcagtg actaccaaat tatatatctt ttgctttgtt ca
#tatttaac 119580
taaagttagt atacgtggtt ttcagtttgt tcacacaagt tcacttatgc ag
#gtgcaaga 119640
aactgtagac ctaatagttt cttagctttg taattaaacc caagtaatga ac
#ctgtttaa 119700
catcttccta cagacctagc atcaaatgca aagggaatat tctcacttag ct
#ttgtgcat 119760
tagtttccct tcacagcata gcagtgtttt cctatggaac ataaaaaaaa tg
#cattgtaa 119820
aatattcatt gaagaccaga gtaaatgcgc acttacatga attcatttta ca
#tatgaggc 119880
agaatgagct tcaccatagt acatacagct tcatttttca atcaataaga aa
#ataaacag 119940
tgttattgct taaagaatta acagtgatgt gaaaggaaaa taggacattt ct
#ctgttact 120000
aataactata tgtttgctat tatatttttg aacagatatc cctattttca at
#attctgat 120060
tcaatacatt ttacactatg aaattaaaaa gtgacattgt gatgtcctga aa
#cgtttcaa 120120
agtctagagt tttgaaatgt tcccaatttt aaagataata tacatctgtg tg
#tgtatata 120180
tatatttttg tctatgcttt ttcaaatgta tattggggga atagctacac tt
#cttaaaaa 120240
ttgaattctt ctttctagaa agacgtagac ctagagaagg atgtgatcat ag
#aatgtcga 120300
attgtaaagg acatgcatag gaagaaacag accaaattct gatattctag aa
#ctagggaa 120360
taacttatga agttcacgaa ggaaacaaat gtaaggaaac atgatatagg aa
#gtagtaat 120420
ctactagaac ctgttaattt ctaagaagta gaataggatg aaaatacaaa ta
#gctttaac 120480
cacctaaatc ctttctgcaa caaaacaaat cataagtaaa tgattttaag ag
#caagataa 120540
caagactcag tcagaggaaa taaacattca taatttcttt ttctttcttt ct
#ttttttct 120600
ttctttcttt tttttctttc tttcttttct ttctttctct ctttcttatc tc
#tcttcctt 120660
tcttttcttt tctcttttct tttctttctt tttggacttt tgatcttgtt gt
#ccaggctg 120720
gagtgcggta gtgcaacctt ggctcactgc aacttctgcc tcctgggttc aa
#gcaatctc 120780
ctgcctcagc ctcccaagta gctgggatta caggcatgtg ccgccatgcc ca
#gctaattt 120840
tgtattttaa gtggagatgg tttttcacca tgtttgtcag gctggttaaa tt
#tctaagac 120900
caggacattt ttcaacgcat ccttttattc tttcttttag agagttaacc ta
#ggttggat 120960
gcaatgtaag tataaaagtt atggacattc ccatgtcttt atatttatct gc
#acctaaat 121020
ttcatccaga ctgtttgctt catgcttatt tggtgatatt ctgtgaaaat aa
#atactgta 121080
atctgattaa gggacagtaa ctgtggaata attagtattt tttcaattgt at
#agaattaa 121140
tggcctggcg cggtggctca cgcctgtaat cccagcacgt tgggaggctg ag
#gcgggcag 121200
atcacttgag gtcagaagtt caagactagc ctggcaaatg tggtgaaacc cc
#atctgtac 121260
taaaaatcca aaaaaaaaaa aaaaaattag ccgggcgtga tggcaggtgc ct
#gtaatccc 121320
agctactcga gaggctgagg caggagactt gcttgaacct gggaggcaga gg
#ttgcagtg 121380
agcccgagat cgcaccattg cattccatcc tgggtgacag agcgagactc ta
#tctcaaaa 121440
aataataata ataattaatt tataatatat cagtatatat aaagtaagta at
#tcaaatat 121500
gtctaactta cttccaaggg agtgtctaat ttgaaatatg taaaatttga ta
#gatcagaa 121560
agtttttttg ctgtgtgact tttnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 121980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 122040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 122100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 122160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 122220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 122280
nnnncagaga ttgatttcat tttaatagaa tttgaatttt agctaataga at
#ttgaattt 122340
tagcttgagc cagctaaatg aagtccattg tttctctccc cctgagtaat gt
#aagaagca 122400
gaatgccaaa tatcacagca tgttttagaa gacattagct taaaacactt ta
#agatgcta 122460
gaattagcag caaatacttg cagaagagat ttccaaatct ccgtttgaca ga
#cgacctat 122520
gaccttcaga aatattccaa caccacaaag aaaagtttag cttgtagttg ac
#tcagatag 122580
ttataaggag gtgtatctag tgaatagaaa cataatgatt ctcttcctta gt
#aacaggac 122640
tagttacaat gtcattaaac tagatcatat aaaattctat atttgggaca ta
#aatcattt 122700
gcagaaatgt gtttaatcat tcccatttct aaacataacc acattgggca ag
#taattgtg 122760
attactaaca atacaactaa ttcattttaa catattatgt gcttaagttt ta
#agaatgta 122820
agaacatgta ttgagtgcct attataagct ttcatgtaaa ttttcttcaa ga
#ggattata 122880
caaaatctgt gttataatga catcttgtag ctgaggtaac caaggagcag ag
#aagcttag 122940
caatttaccc aagcccatat gtatggtagg cagatcatct agaattcaga cc
#caatcctg 123000
tttacccatt tttcctcctt gaaaacaaac aacccatcaa aacaattaag ta
#gtggatat 123060
ttcatgttta gttaaaaatc attactggat gtttcaatta taatatcaac tt
#ggtaaaat 123120
ttctcaggaa aaatagtttc tgacattttt ctctgaagaa aagtaatgag ta
#cagggtat 123180
ctagttttac tagctcttaa aatattctaa aaagtagtaa ttagaaattt ga
#aagaaaga 123240
ataggcagat gaattaatgg aaaagaatga atggtctaga aatagaccta ac
#tacctaga 123300
aaacaaagtg gtgttccaaa tcagggacaa aagatggaaa tgttaaaaaa tt
#gatactat 123360
ttgttgttcc aacgacannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 123720
nnnnnnnnnc agtttcactt gtatttaagg aaatcaaaat aaatattatg ag
#acatcaat 123780
ttgtatttgt acaaagaaca taaagtgttt aataatacct tgtgataatg aa
#agtaagag 123840
aaaacagaat ttttcaaaca ctttggttca gagtatgaat tgttagagaa ca
#attgagaa 123900
atgtttttca aaatttggaa tgcatatata taaaatctaa aaattttact gc
#tggtagta 123960
tattctacaa gtacactcct atatatatgc aatatgcaaa aatttcaatt at
#atctattc 124020
aacattttat aattacaaag tgaatcattt aaataataat aaaaggttaa at
#aactacat 124080
tattatatat tcaaacagtg aaatactgta tagcttttaa aaataattaa ct
#acatatct 124140
ttgtttatgc tgatacggaa agacataggt aaatgaaaaa aacgatttgc ag
#aacagatt 124200
gtatatcact ccatttgtag ctaaagaaaa ttagaatata aagaatatgt at
#agaaaatt 124260
ctggaaatat atacaaggac atattaatag tcattgtctc tgggtggtag aa
#atatggga 124320
gaagaaataa ctttttaaaa tttaccgcca tctgtgaaat tggaatgtta ta
#ttatgaac 124380
tcctttgtat tacttttata gtaaaaaaag tagtaacaat ttaaaaagcc aa
#ttaacatt 124440
gattccttat attttcttct agataataat aacagagtaa agctgatagc tg
#acgctagt 124500
gttccaggtt cggattatat taatgccagc tatatttctg taagttacta tt
#ttatatat 124560
tttataattg tataaaacat aattactgaa attgtattat ctttccaatt ac
#ttaaaaca 124620
acaaatttat tacaactcct atggatctta atatgctagt tatttacagc ca
#cattgtgt 124680
acccttattt tatagatgtg gatatggata tgcctaacag agatactaac tt
#atcaaaaa 124740
ttatttcacc agtgcgcggc agatgttcaa cttcaggcta cacatccctg at
#ctttccac 124800
taattcatat gctttgttaa tgtattctcc atatgcaatg aagtttgcca at
#ctctgtga 124860
attaaaaatt atcaaatgga cagttatgtc catataacat gaaaatttat ta
#tgcagctc 124920
ttcccttcta gatctgcagt ccttcaagcg ggtaataatg ccatcaccat ca
#taggtaca 124980
ttgaaacctt atatgcactc aagatctcca cttggtttgc aaattcatgg aa
#tcttaaag 125040
aaggaagtgc cttgaatttg accattcacc ttgaaactct aaaaaattcc tg
#tcagcctc 125100
ttttggcatt gattcatcca cttcttccta agacgggatt ctatctctaa ac
#aactctgc 125160
tttacagttg ttgggttttt ttttaaccaa gttatgtctc tttatattct ta
#cccactga 125220
cttaaattct aatgcatagc aagcttaacc atcttcatta tggtgaatct ac
#aaatacat 125280
gaagatttcc tctgctgccc acactctcca taggcttttt cttatccata gg
#tcttctca 125340
tccatgccct ctatttcctt cagttctatt aaggctcttg ttatatgacg tt
#ccaccctt 125400
tctccaacgt caaacatact tgtgctgtgt ctcattccct ccaagccttt gt
#catggagg 125460
aaaaaaacga attagttcta aatctgatat tggttgataa ctaatctaaa at
#tacaatca 125520
tatattgggt cctgttgtca aaggagtgaa taatgggaga atttaagact tt
#aagacttt 125580
ttaaccagag aagtgaagga aagtttagag aagctaaggt attctttaaa tt
#tcattcta 125640
ttttaatgct agaactttaa atctgtattt aaagaattac atgaatttac ta
#ttatggta 125700
acattttatt catttatcaa atgattgatt ccctctaaaa tgtaattcaa aa
#tgtaaaca 125760
ttttggtgaa atcttatgct tacaatttcc attaaaatct aaactctaca gc
#atgttaaa 125820
gttttacttg gatttacaaa atgatgcata tatgcattta gatatttaca tt
#tcatcact 125880
actctgataa tcaaatgcca tcaagcagga caaggacaac tggttgtatc ag
#tgacctat 125940
tgatttgtat cattttttat tcaccaataa gtagatacaa atcaacagct ca
#tattgtct 126000
aatgttccat aaggcatgac agtacaggat atgaatataa ttaagaagaa aa
#acagacaa 126060
ttttagtagg tgtagctgaa ccacacagat tatgtaagca aagtaatttt cg
#caaacccc 126120
cagtgtcccc ttgaaatatg gtaggttgtc agcatacaac tatgagcaaa tg
#ataacgtg 126180
gtatgagcaa taaactagga agcctgaaga tatatattct gctgtaatca ag
#tgatgttg 126240
taatataata aatcttacaa caacgtcact atgacccaat gtaatgatat gc
#ataatcat 126300
tgctgagctg catggtaagc aggctcagat ggaaggcact ttacaagaag gc
#ggatttct 126360
atattggggc tggcagtgta ctgtagcact cagagaaatc tcctttgctc ag
#gatgtcaa 126420
gaacagatgg gaacagatgt agcaatgata ctgcagtggc cctcactttc ca
#cctacgta 126480
ttcctacaat cttcacctta gaaagaatgt ctggtatatc aatttccgcc ta
#cccccaaa 126540
ttttattcga aagcacttcc aattgaaagt ttatgaacac ttgtcccagg ag
#caaaagac 126600
agaggtcatc tatgaatgga ttccgggttt caatttcttt ggaagctatg gc
#aaagggaa 126660
gagaactata gagggaggta ggaaagaaag caaaataact agtgttcaga ta
#gaaacatg 126720
aaaaactgaa gtctggggaa gagacagagg aggaccagca tatggtctga gg
#gatgtatg 126780
ttaagactgg gaccctccag cccagggttt ataactaggt taacatgcca at
#gtgtgttt 126840
tcctctgccg ttggccattc tcgagaatgg tgctcccaga gttaggactt gg
#aaaggctg 126900
gaagattttg atgaaggata gactgtgaaa gaggtaggaa gaagtgatat tg
#cagcccca 126960
taatctgcca ccaactgtac aaatgagttt agaaaggttt tcaagagagt ca
#aaaatgaa 127020
aatactgtga ttttaggtat aagaggaagg cttataatta attttgagga ag
#gctcgtca 127080
aaattatctc tcctgtcaat ttcagatgcc tgcaattact ttaatttgat ga
#cagctttt 127140
aacacaacta gagattaaag gctatcatgc aaatggttgc agtaacatta ga
#aacatcag 127200
aatttgttcc tatgttgaca gagcattata atannnnnnn nnnnnnnnnn nn
#nnnnnnnn 127260
nnnnnnnnnn nnnnnnnnnn nnnaatttat taatattgat cgtcctctct tc
#tttgatcc 127320
ctccaaactt tgtatattta gcatagcctt tgtcagattc taactcacag tg
#atctcatt 127380
tattaactgc cttctctgtg tgaggaagag cataaggtac tgggcactac at
#gaggataa 127440
gcatgtatat ttcctcttat cttagtacca cgtaaggatg gagattcagt ct
#tcatgatc 127500
ttactatcaa tccttcaata tgaattgagg acccctaaaa cacatacata tg
#aaaacaca 127560
aacacacatg catgtttata tacatcattt acaaggattt gctagacagt tt
#gggggata 127620
ttaagatgaa gaatctctgc ttttaatgac atcataatca tacaaaagga aa
#aaatatat 127680
atatataaac acatatatgt gtgtatacat aaatatattt gtatatgtgt at
#atacagtt 127740
atattttata tgtctatatt ttatatatgt atatatataa tataaacata ta
#tacatttt 127800
gtatgtatgt atctagatat gtatatgcat gtatataaat tctcccacta tt
#cactcctt 127860
tagcaatagg acccaatata tatattgtaa ttttggaata attatcaaac aa
#tatagaat 127920
atggtgatat atttttatat gccgatatgt atacatttgt atataaacat at
#acatatat 127980
gtgtatatgt acacacatat atgtacacat acacacatat acttataggc at
#atacaaat 128040
atatcaccat caatgcccaa cacattttct ttagcataat aaagcaattg ag
#ggtgtttg 128100
caggagtaaa tataaactgc acattttaca ttttttttcc ctagagctta ta
#tgggtaaa 128160
taaagaaaac ctgttcaagg acattgatag gcactaaaat gtcattattt cc
#tgtataat 128220
atggataaac tttaacataa aaaaatctgc aatttttgga aacctttaca tt
#tatagagc 128280
acttcaaaat tttcaaagca atttcacatt ccttatttta caaatagtat tc
#aaaatgac 128340
tctctgaggt gtgcaagaaa ataatgatta tctctaattt ataattagga aa
#ctgaagat 128400
tagcttattt aagtagcctg ctctacaggg tacactatta gaaaggacta aa
#gtcaaaac 128460
cagtgttcta gtctctaggc ctatacattg ttttcattat tcaaacttac tg
#ccttcttc 128520
tatacaaatt taatgaaata ccttatcttc actaaactta atgctagaat ta
#ttgagaaa 128580
gtatgcagat aattaggttt gcaccattca acattcacaa tagttaaatc tc
#aaaggatg 128640
aaaagaagga ttggtctgac cttctccatc tcatatgcta ttctaaaact aa
#ttgtatct 128700
gcatatacaa attcactgga tataactgaa taactgctgt atgagattag aa
#taaagcat 128760
aaaaatattg atttggaagc aatatttaaa ttactttttt agcatgtagt tc
#cacaatac 128820
ctgagatgta gtaggcattt aataattgag ttcataaaaa ggaggattat at
#ttagatgg 128880
gtaaatacat atgcttcaga gttcaaatgg acctgagttc aaattccttc tc
#tgcatttt 128940
tgtagctgta tgacctgaaa ctttctgagt gaagtttcta cactgataaa gt
#aggaataa 129000
taatcaaccc tactttattc attgctgcta aatcatattt caattattca ct
#gaattaca 129060
cattggaagc atttaataaa tacatgttat ttttattgct gttgatgttt ca
#tggtagta 129120
gattctacat tttcctggct gataatccag aggaaaatct ctgagctaat tt
#aaggactg 129180
caatgaaaag tggcatccat gggtaaaggt cataatgaaa gttgacctgt gg
#aatgaaac 129240
ttacactttg ttccatgtat cacagagctt taaaaaccag taaactctat at
#tccaatta 129300
aagggcaaaa gtccaggcaa gaagtttcct ctcagaaaaa ctcaaaagtt tg
#cacacaca 129360
tattcaaagg tagaagcaga aatagcaaac agaattgaca tactttcttc at
#tttcataa 129420
gatacaatgg aaatatctcc aaaacacctt tgggcaaaca ttttacctgg tg
#ctttacca 129480
ttttctgaaa taaattagcc attacaggaa gaaaacttaa atgtgtctta gc
#ttctttac 129540
atgagaatca aggggggaaa tgtgaccata taaagatata tttaaataac ag
#ataataca 129600
tagatatatg tattaaaaag aaatataaaa taatatttca aatcctggaa aa
#ctgagatc 129660
atataatgtt agttttgtaa ataagttgta acaagattgt ataggaataa tc
#ccaattat 129720
ttatatatgt gtatgtatat aaaatataca gtataatatt tagtatacaa ta
#tgtgatat 129780
attgtctata ttactctgtg tggaacctac tcctccctta caggtactgg ct
#ttctggcc 129840
ttgctcacca gtgggtctgc ataccctccc gtacgtactc agcatagaga ag
#ggtcaagt 129900
tgcctcaatc ctcagtgcca cctccacatc attctctatc cctctgccct aa
#aattgcca 129960
gcttgaattc atgctatcaa gcataggaca caccattgct ctttttggaa gt
#taattacc 130020
atcccctaag tcactttctc ttgtttctta aagatttcac tccgggatca ct
#gcttctct 130080
ctcatcactc ttctgtcata attattgatg atgtcaaaat tcatataaaa ta
#ttgaccca 130140
tagccctgct catcactttc tggacctctt ctcttgcagt gacttgcctt cc
#acatgacc 130200
tcatcacttt ctgccatgtt cacaacctag accttttcac caccaagaat tg
#tagcctct 130260
ccataatctt gattgcagat gtctcactat ctgtccaaat ccttctttcc ag
#atcactgg 130320
actctgataa ttcttcaacc ctgctctgcc ctacagctct ttgattctat cg
#aattttcc 130380
atttctccta acccaatcaa gacttcattt tttctcttgc tcagcttgaa ct
#gcatgcct 130440
atttgtttcc tttcctctat tgtatatatc ctcaactctc aaatttatct ct
#tatagtct 130500
cgaccttttg ataaatcccc aaactttgct aaataaaacc ctccatggat tc
#ttctctgt 130560
gttactagaa gtgtattgga gaaaaattca tgatcacgcc aaaatatctc ac
#tttaaact 130620
catggccact aacctcaaaa acacagcctc ctaatctatt caatctccct tt
#cttctagg 130680
agattctttc tccttcttct ttcttctctg gcctctaaca ctatattcct ca
#ttttcacc 130740
tacatctgat agccttgttt atatttcact gataaaacaa aagcaattaa aa
#gagaacat 130800
tcacaaggtc ccctacttgt ctgcatctgt gtccatatac tcagtctttc tc
#ctgtggct 130860
gcatatgaac tgtcctagtc cctgataaca gccaaccctc tcacttggac ac
#tacatgac 130920
ctctcccttt gcctctcaag aacatgggtt gaggaattct cccttctgca tc
#atcatttt 130980
ttctctttta gcagctaaac aaatctattg taatttctta catcataaaa at
#atcttgat 131040
attataggtt tctctctact tctttattgt tctttttatt tacattatag cc
#ccttgaag 131100
aattgtcaac acttactatc ttcaattccc ttctcttatt tcttcagcac cc
#tcaaataa 131160
gacttggata ctaagcaagc acaacactga atcagctatt ttcaaggtca tc
#aattaact 131220
actcagaaaa ttagccttaa gtctcagtct ccaatttatt tgacttttca gc
#agctctga 131280
ctctttcatc ttagtctcat aggttctatc tcatcttcta gacctgcaaa ca
#aaataatt 131340
tagagctcag tacttgaatt tactatctct ttctaaactc tttttcttgg tg
#attgtaag 131400
agtcagggtt ctctagaggg acagaactaa caggatagat gtatatatga ag
#gggcgttt 131460
attaaggagt gttgactcac acaatcacaa ggtgaagccc caaaataggc ca
#tctgcaag 131520
ctgaggagca aggaagccag tctaagtccc aaaatctcaa aagtagggaa gc
#tgatagtg 131580
cagccttcag tctatgacca aagggccatg gcaaattact ggtgcaagtc cc
#agagtcca 131640
aaagctgaag tacgtggagt ccgatgttct agggcaggaa gcatccagca tt
#tcccagtc 131700
cactgactca aatgttaatc tcctttggca ataccctcac agacacaccc ag
#aaacaata 131760
ctttgtgttc ttcaatccaa tcaagatgac actcaatatt gaccatcgca gt
#gatgtcat 131820
ccaattttca tgactttaag taagagatat gagctgatta ctttcaaatt ta
#tgtctcta 131880
gtttggactt cttactgaat tctaaagtca tatatctaat tgccttcgtg gc
#attcctac 131940
ctgaatatct aatagtgatt tcaaacataa tatgtccaat gtgagttttt ta
#ttttccct 132000
gcaaatctgt tcatactaaa acctcaaaaa cacaggcagt aaaagcaaaa at
#atacaaat 132060
gggattatat caaagtaaaa atcatatgca cacaaaggaa acaatcaaca ga
#atgaatag 132120
acaatctgca aaatgggaga aaatatttgc aaactattca tccaacaagg ga
#ttaatatc 132180
caaaatatac caggaactca actcaatagc agaaaaaaaa tccaatttaa aa
#atgggcaa 132240
atgagctgaa tgaacatctc tcaaaagaag acatacaaat ggccaacagg ca
#tatgaaag 132300
attgctcaac atcactaatc atcaaggaaa tacaaatcaa aaccacaatg aa
#acaccatc 132360
tctccccatt tagaatggtt attatcaaaa agacaaaaaa ataacaaatg cc
#agcaagaa 132420
tgcagagaaa gtggaattat tatacactat tatacactat ttagttttcc tc
#agaaaact 132480
aaaatacaac catcattatg acccagcaat accactactg ggtatatatc ca
#aagggaag 132540
aaaatcagta tgtcaaaggc atatctatgc ttacgcagta agtgctgcag ca
#ctattcac 132600
aatagatgag ataaagaatc agcctaagta ttcatcaaca gatgaatgaa ta
#aagaaaat 132660
atgctgtata tacgcaatgg aatactattt agccatgtaa aagaataaag tc
#ctgtcatt 132720
tgtggcaata tggatgagct tggagaacat tatgataatt gaaataatcc ag
#gaacagaa 132780
aaataaatac cacatgttct cacttatgca gaggctgaaa aagttgatct cg
#tgaaagta 132840
gagagtagaa tagtggttaa aagctgggaa ggggaagagg tgagagtaag ag
#attggtta 132900
acgaatgcaa aattacagct agataggaga aataaatact ggtgtctata gc
#tctgtagt 132960
gtgactataa caaaccacaa tttattgtat attttcaaat agctagaaga gc
#agaatttg 133020
atgttcccaa cataaagaaa ttataaatgt ttaaggagat ggatgtgctc at
#taccctga 133080
cttgagtatt acacattgca tacatgtatg aaaattttca cactgtattc ca
#taaaaatg 133140
tgcaattatt atgtgtcaaa ataataagaa aagattatta aaaactgctc at
#ctggagtc 133200
ttccccatct tcctttggag tcgttattga tttctctgtt tctctcatac ct
#catatcaa 133260
atctattagc aaattcagtt ggttttgcct tcaaaatgta tccatatctg at
#cacttctc 133320
accatctcca ttgatatcac ccatgccacc aatatttctt ggctgaattg tt
#acaataac 133380
cctctaacta ttctccctcc tttcaccttt taaactccca taggttggtc ta
#tggaagcc 133440
cacgtgaaac tgttaaacca cacactatgt ttgaaacctt tcagtgactt tc
#tgtgtcat 133500
tcagagtaaa aagcaaagtc ttataattac tttttaggac ctaaagcacc ac
#ttatactc 133560
cctgcttttt ctagccatta tctgttactc ttccccctca tttactctac tc
#caggcacc 133620
tgctgttcct agaacattcc tgacaccctt ctcctttaag gtcgttggac tt
#gattttcc 133680
ttctacccac aattcttttc ccccgaatcc tgcaggcctc acttctttcc tt
#cttcaaaa 133740
ctgtcttcac attatcacca gtgatatgtg aagtttggag atgggctgga ga
#acactatg 133800
ataagtgaaa taagccagga acagaaaaat aaataccgca tattctcatg aa
#gtatttat 133860
tttttctgaa taacctattt ctgaacagcc tattttctga aaagcctatt tt
#ctgaaaac 133920
tttctctcat agcccttatc acttttataa attctatgta atttgcatac at
#aatataca 133980
ttaatagaca atgtctattt ctcctaatga taaaataaac gagggtagga at
#ttcagtgt 134040
ctttggtcag tgatgaaccc ccagctccta aaatagtgcc tggaatgtaa ta
#gtcactca 134100
caaatattga ttcagtggag aatgtgcata tttaaaaaat ctgtaaagaa at
#caaccaaa 134160
atgttaatgg tccttcactc tggatagtgg gattacaggt gaattctact tt
#ctattatg 134220
tatttttcta aattttcaaa atattctaca ttaacatata ttatttttaa ta
#agaaaaga 134280
tccctcacac tttaactaca tatttaggtc tttcggttga gactggaaag ac
#agaaaagc 134340
tgcagtatac tgtgtattta agagaatcaa gattttctac aagcaaatgt tc
#ctggcttg 134400
cactgtaatt tgggaaaatc acctaaagtg cctcctcatt gttccttaaa gt
#aaaataaa 134460
cttgctggat tacattttag agtccctgga aaatttaaat atatgttatt tt
#ttgtatat 134520
tactattctc tgactactga gacaatttca atgtaaaaaa gtaaatgtta cc
#ttttattc 134580
catattcctt aaagcatctt cctgtttgaa atagatgtca ttccattact ac
#tttttaac 134640
ttatacatta cctttcttta aaagaaatcc acagatactg ttcacaatta ta
#taaactca 134700
agtgtcatgc ttttatgttc caggtaaata gaccaaattt cagagaaatt tg
#ataaatat 134760
acacaaggat gtcataatag atttaagaca gatctcatgt cctatgagtt ta
#ctgtatta 134820
gcaaaatgaa acttcatatt accatgtttt tcttgggtca gaactccaga ca
#gtaaatgc 134880
cactagacta atgactaatg ccacagttta agtagataag taatttctta ga
#ggaagagt 134940
gtacatatat ctgcacaacc aataaataca tggcagaaac atcatggagt gg
#gtttagag 135000
agctggttct gggctcaacc tgccttacca attttgagat cttggcaagt ta
#cttcacct 135060
ttctaagctt caatatcttc atctataaaa tgagcataat attagtacta at
#tcacaatg 135120
attttataag aatattgaat ataagatgct tagcaaactg ctacaaagac tc
#agacttaa 135180
gacctttatt aagttctgtt attattgtaa atattattat gtagtcctta at
#gttttatt 135240
caaaagttag acataaattt tgagaaccat ttgttgtgta gtatatcaga tt
#gtgaggat 135300
aaatttagac gttggaaatt ttgagtattt aagattatct agtatttacg gt
#attctaaa 135360
atattaggta attttacaac cagcatatgt ttcatgcatt gatcgaaaac ta
#aaacactg 135420
tatctgtgaa cacagtgatg cagtgtttgt aattatatcc ttctagggtt at
#ttatgtcc 135480
aaatgaattt attgctactc aaggtccact accaggaaca gttggagatt tt
#tggagaat 135540
ggtgtgggaa accagagcaa aaacattagt aatgctaaca cagtgttttg aa
#aaaggacg 135600
ggtaagttat ttgaaaatgt tttacaaatg ttgttttacg attgtgttaa ca
#tatgtgtg 135660
aatatttcat ctaatactgt gagtcatcaa taacctggac atctataaag ta
#attttaac 135720
ttagtcgtaa taactgtggt atacatatat atcaatataa caatgacgct ta
#tgactgat 135780
gattttctct gaatgcagat cagatgccat cagtattggc cagaggacaa ca
#agccagtt 135840
actgtctttg gagatatagt gattacaaag ctaatggagg atgttcaaat ag
#attggact 135900
atcagggatc tgaaaattga aagggtaaaa aaaaaagggg gggacgagag aa
#catgatat 135960
aaaatatgat tgatctaaat gtctaaaata aaattaattt ctagaactat cc
#ctttcaag 136020
gatacctgta tattcaacaa tgcttttgta ttgtcttctg aacagaattt tg
#aatcgata 136080
tccaacttta gtatcaatgt cactgtattt gttccagatc actctagtta aa
#gtctgtat 136140
taaccaatta gcatcacatt cttaggttga caagagcaga aaaaggagag aa
#aatgatga 136200
gatcactagc tttattttat ctaatgaaga aactgtaata tctgacttga ga
#cagcaatt 136260
tcccaagtca ctcatctcct gaatcctaat aatttgattt tctatttaat ct
#gcagccag 136320
atagaaaagg tagtatggga tctcacttta tgagatcttt atgggatcac tt
#tatgggat 136380
ctcagtttat ataaatgcct atacacacag aagatgatat aaggatcttt at
#acttttca 136440
cataacagat gctcaatacc tgtgtatgga ataatttgtg aatgtgttca tt
#taagtttt 136500
gggtcaaaag tgtttcaata cctattattc tgagtgctac aaaatggcat ac
#tatatttg 136560
aatattaatg tcctatatta acatttattt ccaagctttc ttatgttttc at
#tcatattg 136620
aaaggcaatt ctctttattg taacaataaa aatctctctt ataggaaata at
#gaaaacat 136680
tttatttggt ttggtaaata gtcattttta aaagatcacc ttcaaaaact gg
#gactattg 136740
ccttcaacct tcattgtgga acttaaataa ttttgtcatt cattaatccg tc
#cctttgtc 136800
tagcatgggg attgcatgac tgttcgacag tgtaacttta ctgcctggcc ag
#agcatggg 136860
gttccctgag aacagcgccc ctctaattca ctttgtgaag ttggttcgag ca
#agcagggc 136920
acatgacacc acacctatga ttgttcactg caggtgagaa agtgatcaga aa
#tggccttt 136980
gaacccattg gtctttttat tattaaaatt ccattggtta ttttttataa aa
#tgttcatg 137040
taaatttctt ccagcttgcc gtcttcagag atttcacatt tagcatttct ag
#acacattg 137100
gtatgattta tgttttctga catgatagat ctaaaccagt cttgactcga gt
#ctttttca 137160
cagttgaagt ttggagatta gaggaaaatg tagtatgaat tctacttaaa tg
#agatactc 137220
agaataggta aataaataga aacagaaagt agagttgtgg ttattagtga gg
#agggagat 137280
gaaaaattat tatctaatgg gtacagacct tctatttggg atgatgaaaa gt
#tctggaaa 137340
tatactgtgt tgatatttgc acaacattga gaatatactt aatgccactg aa
#ttgtacat 137400
gtaaaatggt caaaatggta gattctctgt tattcatctt tcaccacaat aa
#aaagattt 137460
ttttaaagta acaataactt ttaatatttt taacaggagt gtactataat ta
#atgtggtt 137520
aaatactgta cataagaaaa gataaattca ttcagttttt aaacttttat tt
#taaaaaac 137580
tcaatatgta atttaaatga ttatacattt tccataaatt tctggatttt ta
#aaattata 137640
agactaatac gtaaatgctt gctcattata aaatatatga acaatgctta ta
#tttataaa 137700
acatgtagaa caaaaagtaa aagcctcatt tttaccttct caattttaaa tc
#cctccata 137760
taggtataaa gcttaatata atagtatata ctaaaaacag tataacaatt tg
#cttctaca 137820
gtcaatgatt gattttatgc tggcatcact gatgattaaa acctttgatg ga
#cagtagct 137880
gtcttcaatt tctctgtatc atgcaaatac actgccatgg gcactaaaag aa
#aagtactt 137940
tctccttttt agcctcaaaa agaatagagt ctcctccttt gtgatttaaa ta
#agagataa 138000
gaagaaagtt gttcatatta ttgaccatnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 138780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnca tatacctgtc tt
#tgagtatt 138840
gatgtaattt tttaaatgaa aatagttttt caattttatt atctatagga gg
#caaaataa 138900
attctagaga aagaaagtga aaaggacaat tgcaacacta tttttcaaaa tg
#aaacaaag 138960
aaaatgctat ataagctaaa tattctacat ttgtaacatt tagcatttct gc
#tggtaact 139020
gaatatttgg tcaatacaga gtctctggta ttaagaattt tcaatgattt ta
#aaaaaatc 139080
tctatacttc aacaacacac cctaaaatat taagaaataa gaggttaagt tc
#cactgatt 139140
aaagaaagac aaactcaaat atttgatagc atattaatga taatcatctt gc
#cttgttta 139200
aacacaatct tggtaaccat aaaaaatcca aagacactcc aaagaaaatc tg
#cctccaaa 139260
taagagaaga aactattaga atttattgct atcatagctc attatcttta tc
#cccatcaa 139320
aatgaacaac cctttgctga ataattttca tgtaatttac ccttcctgta gt
#gctggagt 139380
tggaagaact ggagttttta ttgctctgga ccatttaaca caacatataa at
#gaccatga 139440
ttttgtggat atatatggac tagtagctga actgagaagt gaaagaatgt gc
#atggtgca 139500
gaatctggta agatctctaa acctgcactg cattctaaag ttctagaatt tc
#cacatggg 139560
agatccttag tggcagcaat ctggatggac atgagcttga agctgtggac ac
#cttctttt 139620
cctacattat aagccttttg gggaggattc gggagggcag ctgatagaga tt
#ataggaga 139680
actaatgccc acatgccata gtcaccctgc agcattgtta ctgatggctc at
#cttaactt 139740
gttatactga taggcatgta ggcagtaaca taaaattgat ttatctttat cg
#tttagcaa 139800
ctttgggata tctggaaatg aactcaaatc aatatctttt gaatatcatt at
#cttttgaa 139860
aagttataaa tgggaaaaca gtttaaaata ttgactgtaa taaagttcta tg
#ggttttac 139920
ttctccatat ttatccctat tgcataccag tactaataat gattattgta gc
#acgctatc 139980
aactattaac tgtgaggttt ttgtttgttg ttttggctta taggcaaaaa at
#atttacaa 140040
aatatataca attnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 140940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 141960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 142980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 143040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 143100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 143160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 143220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 143280
nnnnnnnnnn nnnnnnnnnn nnnnnnnaac aacaacaaaa ccaacaacaa ca
#cattgtag 143340
ccccaggaaa tttgaaaggc ctttatgaga gaactctcct gtagtgagct aa
#tatcctaa 143400
gatactttta gtgcctcaag gaagtggaaa tttactggtg tgaactcata ta
#ggggaaga 143460
aaaagaaaaa aagtcaacat attttggatg tccagttttt tgtcgggcat tt
#tatgtatg 143520
ttaaatcctt taaatcttac aatacaggat ttatgacaca cactcccacc cc
#cagatgag 143580
gaaattgtgc atcagaagag tttaattctt aaggtaatat ggctctctag gg
#cagaaact 143640
ggaattaaac ttttttcaca acagtatgct gctttcttgg caataacaca ta
#acggcaga 143700
aggaccttgg aacctgtagg actgtctcac agagttcagc ctgctctgct gg
#caaagttt 143760
acacctatca ttctttccag tggagaagat gaaatcagga cagtcagaag tt
#tcacatat 143820
caaatgtgac ttcacatatt tttttaaata ctagaactca taaatttaaa tg
#atttccaa 143880
aaagattata ttgtgtcaac atatttctgt caataatgta attcactgtg tc
#atgtatgt 143940
ttgaaaacac actcttggaa ttacctcgag aagtaactta ctagcaattt ca
#gtagaaat 144000
tttattgctt tataacaaca cttcaattct taccaaaatt gaattctata aa
#ctagatca 144060
tccacctcat ttacaaaact taacacctaa tgacatttga attttcttta aa
#ttacatct 144120
gcccttaaat ggtaaaggtt gactagctgt gagaattaaa tgagactaag tc
#aacaaaca 144180
cttattatac aactactatg tgcccggcac tattataggt aatcagaata ta
#gcagtgaa 144240
tatgacagag ttctgccttt ataaaactga cgttccagta atgagatgtt ct
#tggaaaca 144300
ttttgtaatc cacaaagaaa tagatattcc taataatgac aaacaatttc tg
#aagacaat 144360
ttcaatagag gagttccaaa aggttttgag gtacagtagc aatagatacg aa
#tataacct 144420
ctgaggctga tcacttttga gaatgttcta tttaaatcat tgtcaatttg aa
#tatatgtc 144480
ttaaacattt gatgatattc ctttaaagtc agatatgttt gttatgtgca aa
#tgagggtg 144540
atttgaaata tacttttttt tttagcttta actacttttg ataaggtcca aa
#ctcagaga 144600
tgctagtagg ttattgaatt atattgaaaa catttaaagg atccaaatgg ta
#ctgaattt 144660
agcccaaaca ttcagatgca atggtaggag tccttgtcca gcacctggat gt
#ttgggtac 144720
ttcaatgacc cactgccttg tatttacaaa tcaggaccag atacttgatc tt
#aagcaggc 144780
cacatatcca ggtgactaac agatttattg gttaaacata ttttaaatgc gc
#tgatgatg 144840
tatagatatg ctgactcaca gatttcaaaa gtaaatttag catttgtatt cc
#aacagtca 144900
ttctaacaag aaaactgtaa gagaatttac caattaggtc taacaggaaa aa
#aactcata 144960
aacaaattta tgtaatataa ttttctactt cttatgataa cagcaagaaa ga
#atatatta 145020
atacttggtg tttagtgaca agtgttagaa aaaaacttga agcttcaaga ga
#ccacagga 145080
atttagaaag cctcctattt gaaatggtag aaaatcatat ctatactatg at
#aaattctg 145140
tgtctgtaac ttagctattt atttgatgaa ttcagtactg cttttagctt ta
#acaatata 145200
actcccttta tgaaactctt catcaatata tttgtttaac cactctgtct tt
#ggtgtcta 145260
ggcacagtat atctttttac accagtgcat tctggatctc ttatcaaata ag
#ggaagtaa 145320
tcagcccatc tgttttgtta actattcagc acttcagaag atggactctt tg
#gacgccat 145380
ggaaggtaaa cagaaacaac agtatatgcc cagcttacta gtttaccacc ta
#cggtaaga 145440
acataaattt cagaataacc atatgttaaa aatgtttaag aagctggatt ag
#tgcacaga 145500
tcaggttttt tttctttaac ttttctctaa tccaagttgg gctaataata cc
#ctttctgt 145560
ctacattata tttttatcat gaaacatttc aattttgaac tgttaacttc aa
#cactctct 145620
tgtaacatgt tactttctgt tataggtgat gttgagcttg aatgggaaga aa
#ccactatg 145680
taaatattca gaccaaagga tacaattgga agagattttt aaatcccagg gg
#ccaaagtt 145740
accccctcat tcttccgaat tgaaatgtgc aaccttaaag aaatatctat gc
#ttctctca 145800
ctgtgccttt ccaaacggat tgaacatttt aagnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 145860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 145920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 145980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 146940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 147780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tatcttcatt agtttcttgt ct
#aagacttc 147840
atagatacta gttactctct ggggtccctg aagcaatagt attaaccctc ac
#acaaatca 147900
gtaaatgtga gtagtagttg gttagacgga tcagtcatgg tagatttttg tg
#tattttaa 147960
tgtagcagat aggagattca agcttttttt ctctcaagct tgagaataca ga
#gggcatag 148020
gtctggctta ccttgtaaaa aatgccagca gctaacaatg aaattctacc ca
#acacaggc 148080
tgggtatttc tctgattttt tgccttgggt ttacagtatt cctagagtta cc
#agaaaact 148140
atagtggaca attagcggtg gatgccaaga gaatgcttgg aactttgaga at
#gttggggt 148200
ggacattaat caattgatat aagctttggg tatggaggac aacgttatgt ta
#taatcatt 148260
agaagaaatt tcaaaggcga taaagaaaaa ctatttcaga aacgctcttc cc
#tgaaacac 148320
caagaaagtg acctattatg ttaatatttt tgttatatgc aatgtgccct gt
#tagttttg 148380
ttagaaaatg tacattttat tatatccatt ttcaaatcgt ttctggtagt gg
#ggttttaa 148440
aatgataaat gaggttcaaa attaattcca gcctcctttc ttttagaaac ag
#tgttagat 148500
tgaatctgca tcaggcgtgt tttcacatgc ttggcttcat aatctctctt cc
#tcccccta 148560
tattgtttgc ctggaatctg cactaaagat aaggcagagt gcaaacctga ct
#cattggca 148620
accaatcaga agaactttat gtggaaaact cccttcgagg aggtacaggc ag
#catgaaca 148680
aaatttttga aaaagtggaa gcaaaggtag aaaaatatgg ttgaaatggc ta
#aaacaatt 148740
ggtacttgtt ttaaaactat atttcatttc tgatatgaaa ccttatcttt tc
#ttttaaag 148800
aaacacctaa caaaatattt atcagatcag caccacagta aagggaaaaa ga
#cattaaaa 148860
attaaaaaag ataaaataac aaatatttat cagaaatgct cacccttcaa aa
#aatctgga 148920
agattttgat tatatatttt tccaattatc ttctgtttgg taaatttcca ag
#taattgga 148980
taaatagttt atatttactt tgttttaaaa tgactcaaat tttcaattag ag
#cataagct 149040
ttcaaaaaca atctggtcaa ctagcagact tttagcaaat aagacatatt tc
#agaaacag 149100
aaaattaatt gttatattat ttatgatagt tatacctaaa acctaggtgt tg
#ttaaatat 149160
ttacatgttt aacacccaag tatacttaga gatcatttat tgtactcagt ga
#tttctaac 149220
aacatgatta ttttggaact tgaacctata ctatttgttt tcattttttt ga
#aactttag 149280
gagaataact ttattttaaa cctctatttt tcaatatcag aaccagaaca ac
#ctgagaaa 149340
cttagagcct tcaatatttc cacacattcc ttttctctgc actggagcct ac
#cctctggt 149400
catgtggaaa ggtatcaagt ggatcttgtt cctgacagtg gctttgttac ta
#tcagagat 149460
cttggaggtg gagaatatca ggtatagttt tcattattgt acttgccgag cc
#tacttgta 149520
tttatatttt gctcctaata ggaaagttct ttattttatg aaacccatct ac
#cacaaaaa 149580
cttactcctt gttgggtttt tgaaagcata agttgaagac aaaaacgttg at
#gtcaaact 149640
gatgagtgtt aagtttcagc attggtggac tgttacctta gcaacatcta tg
#ctgctttt 149700
tttttttttt tttttttttt aagttcaccc tgaacctaca gccagtcatc ca
#agggttca 149760
tgaatagttt aacaaagaaa aggcagagct attgagtaat acgggctcat ta
#attgtgta 149820
cttgccagaa ggatctgtct ttaaatcatt aatgcaggca acatttctct ct
#agagccat 149880
caatgtgatt ctactggctg aaaaatgtaa taaagatgga ttttcttatc at
#ttttcttt 149940
tactttttat tgggacttca gagacacagg tatttcgtat acactcttta aa
#aacaaggg 150000
ctaagtcatg ggctgtagat ttctcaagac ttgaatagtt gttccttgtg ac
#agtgaact 150060
aggatagata gaaatgctga cttaggctgt gataacgcag tacgttttgt aa
#gtttttat 150120
tttaaagtca tttggtaaaa agttatataa catatttgta tcttacaata at
#atggaact 150180
tattgtgatg ttataaacag tgcagagtta tatagtgaag agttaatttt tg
#ttatagtg 150240
atagatttat tttagcttgc ttgctttcca gaaagaattt taatgcaact at
#ttgtttgt 150300
gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 150960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 151980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 152940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 153900
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nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 198960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntttc tttgaccttg gt
#acctctct 199020
cagggatgag gactctcttc ccatttctat tgatcttctg aaaaagtagc ct
#cattcccc 199080
aactcaagga actctttaaa tgcttgaaat cttattagaa gtcaccagtg ac
#ctccccag 199140
tgtgcaacac aagtaattaa atatttttaa ccacccttgt gttcttatct cc
#ttcaaaat 199200
ccatccctct gtccccccac ttttcagctt ttgaaactat ttgttcctta at
#actttctg 199260
caattttatg tactgtgaca ttgcaattct ttggccttgc acaattaaaa at
#gaaagttc 199320
aaaaagctaa ctctctctat tttctaactt tttagtgaag atgttccaca ga
#gctttggt 199380
ttcagccatc tcataacatt ttcttttgaa gacctaacag tttcaatcac tg
#cttcctat 199440
ttgtctgact cttttgcctt actttctact ctgatccttc tctctgacgc tc
#tggattcc 199500
taattgcagc catttgtggg aagagtccac cagggctcat tacatctaaa ta
#aatttctc 199560
cccataaaac aaaacagaaa tcttctctga gataataggg gcttcatgat gg
#gagggaag 199620
atgtgacatt ggaatgagga cagagatctt gggacagtga tagtgacctg tg
#caggttcc 199680
cacagggcac ccataaggtc tgtccaggca attaatagtg tcagtgtgtc aa
#gaataagg 199740
cctaaagagc ggctgacttg aagtcttggt acctgggttt agaattttct aa
#tccctctg 199800
actggacata acacaaatct ctgacctcaa ggtcatttgt ctannnnnnn nn
#nnnnnnnn 199860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 199920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 199980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 200460
nnnnnnnnnn nnnnnnnnnn nnnntcatca agctagtaag aagggtctat at
#aatgtgat 200520
catgggagag acatgttatt ccttttgcct tattctattg gttagataca aa
#tcataggt 200580
cccaactaac taaagaagag gagattttac aaagcaggaa caacaggagg tg
#ggtatagt 200640
gggtatctac ctgagaggcc atgcactaca ctcccccagc ctactatttt at
#atttcaaa 200700
cacttattag aataatcctt ccagatttaa gtatgttatt tacattatga aa
#gtaaccta 200760
ataagaattg agaacagatg acgaaggtat atatgtgttt aagtaaccta ac
#tcttcact 200820
atcattgcag aaaatcaata gattctaaaa atgagtgtta acagagcagt at
#atgcatat 200880
tatttagtgt tttaggggta aacaccataa gaactgaaaa caggagtggt tt
#aaagtgtt 200940
gcttctggga agtaagaggt agggagggta taaacaggga attgttattt tc
#attataaa 201000
cccttcatca tctttttttg tagccatgta gatataacat gatgattaaa ct
#taaaaata 201060
taaccctcct atgctaggca tgatttgatc tcattaccct tattgaattt tt
#ttccagtg 201120
aatcccatga tctatttgtt tctgaataaa tatggattat ttaaacaagc tg
#aaatatgt 201180
ataagatttt actgttaata tttaaacaaa tatttgaaaa ttacattagc aa
#aatgagtc 201240
tcagggtttg agatctttta tttcaacttc cacacttata tatgtatctg at
#ctataaca 201300
ttcctaataa atgaggtgaa tccagcctct gctaaaatat ttgatcaact gt
#tataggat 201360
atctaccact gcaaaagtag ctcctatcct ataagctttg aagtattctt tg
#ttatggtc 201420
ccataagcat ctatttctta agtaatcatg aggttttagg cactctgtta gg
#tacagaaa 201480
cccatagatg aataagaaac tacggtgttc tttactttga actgaaatac ct
#gtctttta 201540
attttcatca gttcgtccta agtctcctct ctagaccaac acagtagatt cc
#agtggtta 201600
tgaacatgaa ctttggagcc aggaaaaatg ttccaatcct acctctgctg tc
#actagttt 201660
tgtgaacttg aacagatgac tgtaaaatgg agataaaaat catctatctc tt
#tgggggac 201720
aataaagcaa gatcacatga gtaaaagtat ttaacactct gtaacacaca gt
#agcttaaa 201780
atgttagcct ttgcagtaac aacaataata aacaatgatt taactctttc tc
#attgaaga 201840
taatggtcag agttttccga agacttaata tccttagttt ttattagtca tg
#gcttctag 201900
gtccttcata tcatggatta tattcctgtg catattttcc agtttgtcaa gg
#atcctctt 201960
actcaccctg aacacaatat tctgtatgga gtttgaatgg agccaaattg ag
#cataatta 202020
ttttctcctt cgaagtaaat ttcttccttc tttcaaaaca gtgaaataaa aa
#aaaatcat 202080
ttcattggga gcctcattcc actgagactg aagtctaaaa aaccctgaag tc
#atttccgt 202140
ggactgctct ttgcttgaac ttcacagtca gatcccatcc agtacttgtt ca
#attagaaa 202200
cctgagacat ttttctccaa cagacatatt gctgcctagt attacagact tc
#tgagattg 202260
atatagatgc atctttttca tccaacatat tccttgagaa tatcaacgtt tg
#tcactggt 202320
gaatgtaagt cttgtgctaa gtcttgtgcc aagtcttgtg ctaagggctt gg
#ctggttgc 202380
taggaatgag gctgaggaca gaacccaaga gtagtttagg aatgtcttga ga
#taggttta 202440
ttttattcag cattaggaac ataaacggag tcaagactta aagatttgtt ca
#cctgaata 202500
atgtgttgaa tgatacggta tcctttagaa aatttcccag catatgctaa tt
#aaaaaaat 202560
ttttcttttt accacttctt gataacagca caaatcatgt tttagtctac at
#taaaatat 202620
agaagcattt cttaagaata agtcaaacat ttcattaatt caattcagca ga
#cctccagt 202680
gaccccaaac tgatagatgt gatagggttt tttagaaaat acaattacat tc
#actataat 202740
gaagattact acatgtaaaa tcaagttggt ttattcaggt ggattaggaa tt
#tatctctg 202800
aagactccta attctttcac ataaattcca agaattcctg ggcagcatag gc
#aaggcctt 202860
tcatgttgac aaattgtgac attccctaac tcaatggtgc tcaaccagcg gc
#agttttgc 202920
tctccaagaa acatgtgtta atctttgaag acatgttcat tgtcacaact ga
#ggtagctg 202980
ggggccaggg aagctgctaa acatcctaca atgtacagga cagcctccgc aa
#cagaaaaa 203040
tatctaattc agaatgtcag tagtgctgag gttgggaacc ctgtattaaa tc
#agtgagtt 203100
gcaaattttt aggtgttgca atggactttt ttccctccta tttctctcat tt
#ctactgct 203160
gcttctctct gccccttccc actactctct taagtccaaa ttctttccca ac
#atttttgc 203220
ttttaatatt attacttttt ttctcattat gaaaacttaa ctannnnnnn nn
#nnnnnnnn 203280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 203340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 203400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 203460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 203520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 203580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnncatatag ag
#ttccctat 203640
ccatagttct ttatcacaac ttttaaaaag tagcttttat gggaaacctg tt
#gcttttca 203700
tgacagcact tttctgggta gagttgtaac aagatttaga caattgcatt tt
#gtaaatat 203760
ttggaggact gaagattttt tgactcattt ctccattctt ttatctttca ga
#agaattaa 203820
tatttaagta acttgccatt gtagatagtt aactgaaatg ccataaaatt tc
#ttgcttta 203880
ctgaactttt tcctgagcac ctactttctt ttttggaaag tattaagtgc tt
#tgatattc 203940
ctaaggccta gaaaacctgt ttttggctct ctgagtgaag acaactccaa aa
#catgtaag 204000
ataattaaaa gacagatata ccaaaactta taaacaactg aaacctatat ta
#tgaattaa 204060
tataaactct gagggtaaaa gagcatggaa ttgataagga atagaatttt tt
#taaaaaaa 204120
ggggttttgg aggtaagttt tgaagcagaa cttgaaaaaa attagtaaaa ga
#gagtagat 204180
ttttcagcat attctttttt caaaactgtt tgattttgga aaattttgaa ca
#ggtttaaa 204240
agtacagaaa agagtctaat aagcctccat atacctgcca cctggattca gt
#aatcatca 204300
ataggctgcc attcttgcct ccggttttta aataaattcc agacttaaca tc
#attttgtt 204360
cctatatgcc taagcacgaa tttctaaaaa ccatggacat ttccacccat aa
#aataatgc 204420
catgaccaca atgaacaaaa ttactaatac catcctggta tcatttaata cc
#tagaacac 204480
attcagattt ccttgattat cttcacatcc tatgttgatt aggtatgttc ta
#attagact 204540
ccaaacaaag caacattttc tttgattaat gtgtagtctt atttccaaag tc
#aacattct 204600
acacaaatat ccaatattat ttggccataa caccttttcc ccattttgtt tc
#aatcaatt 204660
atgctagtgg ggatgaagaa atgagaatca tctagttagc tcaatgaaaa cc
#tctactgt 204720
attcatccat aatctgttcc tgatgttttc acctcagtgt ttgccatttt gg
#tgaacttg 204780
acatgtgtga attacattat aggatctagg aacaattgca gttactttaa at
#attcctta 204840
tgtccagagt cttgacaggt atgccatgaa tcctgtgtga aaactattaa ta
#ttaccatg 204900
tagttttatt ctggtatgta acttcactct attataaact attatcatta at
#gtatatca 204960
agcaggcata tagacctctc atgtatggta tacaaatgag gacaggtaat ta
#gagaagca 205020
aaacacattc taatacatca gtatgcctag aacacttacc atttgggggt ga
#tcagttac 205080
aatatctcag tcatgaaacc tttgcatgag gacgtcttat cttaccataa ag
#aaactaac 205140
tcaagtcaga acaaaatctg tttcttccca aaatacagta ttgttctctt ag
#gaaataca 205200
atgatcacaa tgtgttacaa tgattcaggg tattagtagc cggagaatga aa
#ttttggaa 205260
tctaaagaag acagtggtca tggaaatatg ttatctttta taacagcatg at
#tccaaagt 205320
tataggtttt ttagaactaa tacttgattt aagtcatgaa gtgtaactgt ca
#cagtcttt 205380
taaaatatct acttttaatt acagtatata aatgacccca tggctccaga aa
#ttgtgaac 205440
atagtagagc caatggtagg attatatgag ggttcagcag agatgtcgtc tg
#accttcac 205500
tcacttgcta catttatata taacagccat ccagataaaa actttcctgc aa
#ggaataga 205560
gctgaagacc agacttcacc agttggtagg tagaattttg attttctata aa
#gttcattt 205620
aaaccaccag tgctagctag cacagaaatg aacctaagct tagagttcag cc
#atattatt 205680
aatggtcttt gggctggagt cggatttttt tttagctgtc ggaaaacctc at
#gcaacaaa 205740
tggaaatgcc acacaggcag aagctggccc ctcctaaccc atttgacctt ct
#tcctggag 205800
aaagtagcac cctagagtct ctggccaagc tgcatagaca atcagttatt ac
#agttgcca 205860
aagcaggtgt gatgggaagg gattaacata tcttcaaatc atttacaggc ct
#cacattct 205920
ctacagcttt tgactaatag gttttcaagt gtcactaaag gtaaataggt ca
#gaaagtta 205980
caaatctagt gcatggtgtg ataaacaggt gtaggtgacc ccaacgatgt gg
#tgatgtca 206040
ttagtgtata cacttgctct tcagtgtcag tggctcttac agtttctaaa ag
#gagaatgt 206100
catacgtggc aaattaaaaa tactcacctg acacatatta tctctctagt tt
#ttctaaaa 206160
tgttaaatga gaaaaacatt ttattacctt ttctctaatt tggtacttgt cc
#cattcaaa 206220
attaaaagtg ttattctatt tatggtagaa ttagtaaaaa aaaatcacat ta
#cattcaat 206280
agatgtttat atttcactta ctgatccatt tttcttgtgc aaagaagact gg
#agggcaac 206340
actgaaaatt aagagtccca tgatttctga tgcagacatt cccttaaata tt
#tcaagttt 206400
ggcctaattg ctacttaaga gttttagaag cacaaattct aaataaagcg aa
#aatctaac 206460
atttgaaatt cttctgggat atttatttgt cagttatcca agcatgcttg ct
#ttcaagaa 206520
ttattttggt ttactgaatg tatgaacata tggtgaaatt tgagtccaaa ta
#aaactctt 206580
tatttattta actcttttac taaaacctgg tattgattta taatatctca at
#tatatatt 206640
tctttaactc ttctactaaa tcctggtatt gatttataat atttcattta ta
#tattattg 206700
cctactcttt cttttcagaa aacattccta accagcctct ttaagaaagt tg
#ttttctta 206760
aaaacactaa tgtcatgttt cagagtaatg tgtaaaaact aacaaaatta ta
#ttatgaac 206820
acaaaatgtt tgtggttatt attgggaggt actcagaaat tcatagtaat at
#tcaatacg 206880
atctctaaaa ttaatatttt tatgtttact attattacac atctaacttt aa
#tagaggtg 206940
tgcatggaga gattaatgaa tacggagaaa tcaggtttaa gattttatag tc
#taagaaaa 207000
aaataatttt gattgtgaag ccaaacacct ttcttttttt ctctttttac tg
#aattcaaa 207060
cagtaactac aaggaatcag tatattactg acattgcagc tgaacagctg tc
#ttatgtta 207120
tcaggagact tgtacctttc actgagcaca tgattagtgt atctgctttc ac
#catcatgg 207180
gagaaggacc accaacagtt ctcagtgtta ggacacgtca gcaaggtaag ga
#tgtatttc 207240
ctttgaaaca attaactgca aatattgctg ttgtacactg tgatactttt tt
#ttcattca 207300
tatgttcatt cttcttttta agtgccaagc tccattaaaa ttataaacta ta
#aaaatatt 207360
agttcttcat ctattttgtt atattgggat cctccagaat atcccaatgg aa
#aaataact 207420
cactatacga tttatgcaat ggaattggat acaaacagag cattccagat aa
#ctaccata 207480
gataacagct ttctcataac aggtagaaaa caatgttttg ttgttgttgt tg
#ttgttgtt 207540
cattttacat ttctattctg gtggaaaata tgcccatctc cctgtgcctt at
#atactaca 207600
gaacacatgc tatgtcactt catattttgt tgttttgtgt caccatgaat ct
#ttttaaaa 207660
tacctgcata cataactcga ttaaatgtgt ttttctttta ctagatttac cc
#acaatgaa 207720
gtaaaaagca tcagatcaca agcttcatag aaatttactt aactgaagga at
#actgtatc 207780
tggtatatca aaataactca ttattgaaga ctaaaatgta cgaatgcaaa aa
#tcagctga 207840
agtaattcag ctgacatggt atttgtgcca agtcaactat acaccctgca gt
#gtgccaaa 207900
aagttacttt tgcaacttta aattattgcc ttaatatttt aggagagaac tt
#gaagtcac 207960
caacatagaa aggcctataa gcccaagaat ttgaggagac tgcaattatt tg
#gaagcgat 208020
atagatatct agtcccccgt ataaattctt cttactggcc ttatattaaa tg
#gcaccaat 208080
cccaagagta ttattttaag gacattaaac agtttgtctc ttgtccttat ag
#ggttaaag 208140
aaatacacaa aatacaaaat gagagtggca gcctcaaccc acgatggaga aa
#gttctttg 208200
tctgaagaaa atgacatctt tgtgagaact tcagaagatg gtaagaatat ca
#attgcagc 208260
tttaattttt ttaaaaaagt ggttgtaaat gctcactgcc ttcacttcat gc
#tacctcta 208320
gggtctaaag caacaaacat caataaaaat ataggtacta caaatgttct tt
#tcttcccc 208380
tagaaccgga atcatcacct caagatgtcg aagtaattga tgttaccgca ga
#tgaaataa 208440
ggttgaagtg gtcaccaccc gaaaagccca atgggatcat tattgcttat ga
#agtgctat 208500
ataaaaatat agatacttta tatatgaaga acacatcaac aacagacata at
#attaagga 208560
acttaagacc tcacaccctc tataacattt ctgtaaggtc ttacaccaga tt
#tggtcatg 208620
gcaatcaggt atcttcttta ctctctgtaa ggacttcgga gactggtgag ct
#tttgtttt 208680
gctttgtttg tttaataata cacagtgata tagtaagcaa agctgataat cg
#ccatgttg 208740
tttacatttt acataaccta aaatccctca ttattttgtt ttgtataatc ca
#gaaattaa 208800
ttttcttttt caggcaaaag tgcaggaaaa ggtttattgt acaaattttt aa
#gtctgatt 208860
tatataaggg aacttctaat caaaatctgt gaattttcaa atgaaaagac ct
#tgagaaac 208920
caaggattct ttcaatgtac ctataaattt tagattgaat ggctacttgc tt
#tcgagtta 208980
ggtaaaactg agacatactc ataggaatag attctgagat tctaatgagg ta
#tgtgtata 209040
gatagtggtg cagagtggga gcacgaaaat ggcatgcctg gagaagactt at
#ggaggaga 209100
cagcatttgg cctggatctt aatgaggagg ttggaatggg cagaaggatg tt
#atagagca 209160
ggggtcccca acctttttgg cactggggac cagtttcatg gaagaaaatt tt
#tcccctcc 209220
ctccggacta gggaggggag tgaggttggt ttctggatga ttcaagcacg tt
#acgtttgt 209280
tgtgcacttt atttctatta ttattacatt gtaacatata atgaaataat ta
#tacaactc 209340
accataatgc agaatcaatg ggagccctga gcttgttttc ctgcaactag at
#ggtcctat 209400
ctggggggta atgggagaca atgacagatc atcaggcatt aaattctcat aa
#gaagcaca 209460
caacatagat cccttgcatg ggcaattcac aatagagttt gcgctcctat ga
#aaatctaa 209520
tgtcgacact gatctgacag gaggcagagc tcaggcagta attcaggcga ta
#gggagtgg 209580
ctgtaaatac agaagcttta tgatgctcac ctgctgtgtg gcccagttcc ta
#acaggcca 209640
tcagctggta ctagtccgtg gcgctgggat tggggacccc tgttatagag gt
#tgctggat 209700
gggttgggag aggatatccc atctaaagga agtaaaacaa gcaaggaatt ac
#ttgtgttt 209760
tagtttcggt gaaactagag taagacagtt tgtctgttaa tcttattttg tt
#gtttatat 209820
tgtgttataa ttatatattg gtggcataac tattaggcca attctacaat gt
#attttgag 209880
aattaataac taaatataaa gttactattt taattgtacg tttaaaacaa ta
#aatattta 209940
ctgactagat actggtggaa ccacatgaaa taatttttat aggtcacaaa tg
#gccaaata 210000
tcagcaattt catatagttc agccagatac tatatacgaa tttctgtctt ga
#ccttgagg 210060
atctagaaat ctagtaaagt agcttacttt tgtagaaaag tatcctgttg ag
#actattca 210120
cagaaatgaa tacaatgaga tgatacaaaa gagcccatag ataatggcag ta
#gttgaaag 210180
tgcaggaata agaaagtaat gaaaggagca ttttacatta tcaagagcct tg
#aagtgaca 210240
cttaattgat attaatccat atattggcat gtttcattgc ttttgtagat at
#tgtacctg 210300
aaataagtat ttttgagaaa aatgtctgct ctttaatgac tcagttttat tt
#tgcagtgg 210360
attaaggaaa tgaaacaagc atatttttag cacctattaa gggtcacggg cc
#ctgttgat 210420
aggtttcaca gaaactgtct tttaaaaatt ctaaactaaa gcaatacatt at
#tgttatct 210480
tcacagaaaa ctaagtctaa tgaaaaatgg agggtttgag aggttcattc at
#tcaaaaaa 210540
tatttataat ataccaggcc ctactgggga taaagtagtg tagaagaaaa gg
#atttcctt 210600
ccctccttaa gttttattag ttggtgggtg tttcattgcc taatggcacc ag
#ctggaaag 210660
tgatcagctg gaaagtgatg agctggaatt agaatccaaa cccatctgac tg
#taaaaccc 210720
atttcccttt cacagcacat gctgtttttg aagtaatcaa caaagctggt aa
#attataaa 210780
ctatatctaa gatctctctg ttcattgtta cactgatatt ttgtcattag gc
#ttctgctc 210840
agcatgggga ggaaagtaat aactttgaaa gattctattg tgatatgaaa ta
#ataaccat 210900
ttttatgaat gcttatcaag tatttcgttt aagtggccat agcatcaaga ac
#accttatt 210960
ttaatgatga attataaagc aatgtttttg ttttctgatt attacatgca ca
#taatcttt 211020
tacttagtat tgaaaatgta attttatttt ctgttttatt gtctgtatga gt
#ttaattca 211080
aaggcaggga caataaactt taagtgaata taaattttga gatttagttt aa
#aatgagaa 211140
ttttaatttt ggaaagtgtc ttagaaaaca tgcagagccc tttatttttt ag
#gtgagaag 211200
acctaggacc atttgggtaa aaggactcac aagttatagt acatgagaag ta
#aagttggg 211260
gcttgactat aggcctcctg acccccatta caggcctcgt ttaataggct cc
#tgagatgg 211320
ctaaaaaaat aaagagaagg ggaaaccaac atatcccatg gcttcctagc ca
#ggcctaac 211380
aatcagagta tagggtttaa tgcccatctt cctaatatct ggttctctgt cc
#taagttag 211440
ggttgtctca agttctgtgc attttccacc tggatgaaaa tggaagacaa tg
#gaatctac 211500
attagtgact tttcctagat tatgtttgct actgttaaac cacccacttt ag
#ctcctttg 211560
gcaaaagagg aagctaaaat gttaggtagg gtctcaagtg tcatttgaag ca
#agatgagc 211620
tcaagagcaa ctatttttct gggtttaggc tcaaaataat cttattaaat ac
#agtaatta 211680
taccttctat tcatgtaaaa aaatatgggc ccactcttca atattgtttc at
#gagaaatt 211740
gagtgatgtg ttaactcagt gatgtgttaa tattactaat taaaaatagg ag
#taagttat 211800
ttggttaaat gccttatctt tttaagagaa atagagttta ctaatgcttg ga
#agtaaaac 211860
acccttgtgt tcaagcagga aagatcaata caagattgat tctgtgtgtg tg
#tgtgtgta 211920
tctctgtgtg tgtttgtgtg tgttttaatc atagatgtgc agttttccaa ta
#agcctaag 211980
attagttttt attttctcat acttagggtg taataatcat aaatacaact tt
#gagaagtt 212040
cccatacaaa ttactctttt gatgatctat acatattccc tttccttttt aa
#gacacaac 212100
catctttact gtaagccttt aacaaaacac cttgtctgat ttggggcaac aa
#ccatgagt 212160
ggataataac ttagatgttg accaaaattt tgtgtagacc cccataaatt ta
#tttgtatt 212220
aatgaataac attttaaaat ttgtctgcat acattaaagc tttatatgcc aa
#acaatagt 212280
cttttggcag attcaaggta acttcccttt tttactatca tcatggacta tg
#tatttttt 212340
ctgttttgga attttaatag gttcagctta ttccaactga ttataatcat tc
#ctttttat 212400
ccatcagtta tctactttat aaaatatttc tataattcgg ggacactctg ct
#atttcaga 212460
aaattctaaa tgcgtcatta ctcttcaaaa tcagtaagtc attgagtctg tc
#ttgcttta 212520
tctacctgat gatccagcac tagttattcc ctaagggtaa atgaataaaa at
#gcaaagga 212580
tatcagcctt gggtcaggaa tacatattta cacactgact actggtggta gg
#cagacaac 212640
tgcagagaga aaacttcaat ctaatgggaa attttcaaaa tcagaagtta ca
#ccgagcta 212700
taaaattcaa gcatagcatc acaaattccc tttttgtaat taaagagttt tt
#aaacccaa 212760
tcttttatct atctgttcct tacctgtgag tttctctctt gttttaatat at
#tctgtatc 212820
atattaaata tattgattca ttcactaaac agcttttatg ggttccatat ta
#tgttctac 212880
caccgtacta ggtagtgtag ctgtagcagt aaacaagaca caataaatct ct
#accttcct 212940
gaaacttgac actagacaat cagaaaatta gacattagaa aataaatcag ta
#aacaaatt 213000
tgtgattttt ggtagtggta agttttacta agtgaaaaat atcaaggata ga
#agagagga 213060
agagtagtga gtgggctatt tgagatggag gactgaggaa agacctcact ga
#gaggttat 213120
atttgcccag tgatattaat gaggtacagg attgaataag atgaggatga gg
#atgaaaag 213180
tgttccagag gaagaacagc aattgccaac ttcttataga ggaaaaaaat tg
#tggagttg 213240
gggcagagca gggcatttct gtcacttgaa cagtgtgagt tggggtagag aa
#ttcacaga 213300
tgaggcgaga ggcagaggtg gatcctgaga ttcttaggtg ccattctagg aa
#ctttggag 213360
tttaatttta atgaggagct tttggagaat tatggaatag gaacattata tg
#atttacag 213420
ttttcaaaga ttgctgctga atatgttgaa tgttgaagta aagagaaaaa tg
#aagataaa 213480
ctattagatt gtttgtctga gtatctgggt gagtggtagt gccatttact ta
#gatggggc 213540
agtccaggga agaggtcaat atggagaaca tccaggagtt ctgtttgcaa ca
#tgtttgaa 213600
atatccaagt gccattatga aggaagttag ataaataagt ttaaagctca gg
#gaaaagat 213660
acagagctga atatataatt tggagcctca ccacatcttt ggtattcaat ca
#agggatga 213720
ggataaagtc atatcactgg acaacagggg gagacgttaa gaagcttaca gc
#tatgtcgt 213780
gggcaatacc acacatagac tttgagaagt agaagagcta atcaaggaca aa
#gcagaagt 213840
cactggaaat agaaggaaaa ccagaagaag atagtgcctt caaagccaag tg
#aataaaga 213900
ttttcaagta gaaggagttt attccctatg tcacatgctg ctgacaagta aa
#gtaagatg 213960
gggcatacaa ttgattagtg tttggcaaga agggaggtca ttggtgactt ca
#caggagta 214020
gattttacag aaaaaataat ggagaaaaat gaagtcagat taacagagta tg
#ataggcaa 214080
aaaaaaatgt agaaaatgag gaatggcaaa ttttgaggaa ttttgataag aa
#gtggagag 214140
tagacttcag taatagctga aggaacaagt gcaatcaaaa gaagactttt ta
#aatcccag 214200
actgtatatt acagtgtatg tgtgttcaca tgtatctctg actaacttca aa
#tgtaaagt 214260
ctctgaatag gcagaaggag tgaaatccag tgcagacgtg gagggataga gc
#ttggaaag 214320
gaggaaagag ggaaggcagt taagggaaaa tttgaagtca gatgataatg ta
#gctctctt 214380
ctcagtgttt ttatttttgc tatggaatga gaagcaagtt tattagcttc aa
#ataaagag 214440
ggggagggca tatcagaggt ttgtgaagag agaacatggt gaaaacatac tt
#taaagagt 214500
gggagactga attaactaaa acaaaaacat tagctatcag gaaatgaaaa gg
#atccattt 214560
gagatttgat gttataaatt taagtggaac tagtcagcat agaatggtgt tt
#tattcagc 214620
cattttcagc tattacactg ggcatgtgaa gctagcagag ttttgtttaa tt
#ccaattgt 214680
aattttccca ggaaagtaaa atagaaacag aaggacctga tggatattgc ta
#ggaagtga 214740
ttacagtgac tgtggactct agcctgagca tgtagggaaa tgaaggcata ag
#agaggtga 214800
tgcacagtga agatttgatg agggtcagag aattgttgga ttcaaagtac aa
#gagtcagt 214860
aaactggaaa gataggagtc agttgtcaaa gagaggaata ttggcagtta tt
#ggtaatga 214920
caaagtctta ggtgttgcca tgaaagccaa tgaggtacgg tggggtaaag ta
#aggtgggg 214980
gaaaagatta ttggaattat agagataaag aaatacagag tccagggaac tg
#gatagatc 215040
atttgcatgg aagttggcct ctctgagtag tagggaagaa gtcagttatc aa
#agtgatag 215100
catctttaag atgttcagag aagtgacaga ggtattacca gttgtctgtc tt
#aaagaggg 215160
gtagcacgtg atggtatcta atggaatggg gcttcaaagg atctgtggtt ct
#tcaggaag 215220
aaaaaaggag taataaatgc aactacccaa ctcctacacc ctatcgttag tg
#agactatg 215280
gtagaaaaac aaacatgata cccaagaggg ctaaactgta gtagtatttc tc
#agcaggtc 215340
caagatttca cttagagcta gaaagttaag aaagcattga gggtagttgt tg
#aggatttt 215400
cctcaatgta atgggttggc ctggggaaac actagagaag atttagcaca tt
#tcagatag 215460
aaaggatagt ggaattatat tgctaaatcg aactatgcat tgaattgcaa tc
#ctctcaaa 215520
gttttaaaag tatcaatatt cttaaattag tttttcctat taagtgtgcc tt
#gacaccat 215580
aacccaataa ctggtaacaa tcaaggggag ggacactgta tctacatttt ta
#aggcttct 215640
gaattttatt tatctactaa atttattatt agtaattttt atatgcattc aa
#tttagaat 215700
actaataaaa agtttaattt ctttcatttg aaagaaaaga gttttataac ag
#aactcttg 215760
aatggcaata atatttacct atttagttta tattgtttaa ccctccaagt ta
#attattta 215820
tgttattgtt ctatgtactc aatttttaaa ccattatctt ggccactctg at
#ctttcatc 215880
tgtggtaaat agttttctac ctaaagtaca ttgtctacaa tttcatttac tg
#aggatgtg 215940
ttgaaagcat tatccctcaa ttttttttat tgtctgaata tgtttttagt tt
#gctactct 216000
ttatttttct gggtatggaa ttccagttgt ttttcagttg atgttgattg tc
#agtctaat 216060
tgtcattcct atgtagaaga tttttttttt ctggtactgt taagatggtt cc
#ttttttga 216120
tattctgtat tttcacaatg atatgtctaa atatggttta aaaatttctg ct
#tgagattt 216180
actgaaatta tttgatctga tgtttgatgt cgttgaataa ttttgatgag cc
#tcagccat 216240
tatcccttta aatatttctt cattttctct actattttag accccctccg ga
#tatcatct 216300
atgtctcaac tgccatttta tattttccat aactgtcttc tttgatctac at
#tcttgata 216360
atttcttcaa tactatcatc cttttcacta aagttctctt cttctttatc ta
#atctgctc 216420
tttaatacct caagagattt ttaattttag ttattttgtt ctgttccaga ag
#gtctatct 216480
tgttctcttt caaacttgct tggttattta atattattta ccattattta aa
#taattatt 216540
tgctcatatt ttaaaatatg tttgatttct tgaaacacat taaacatttc ta
#ttttattt 216600
caatatctgg aatctcaaaa tctgactact gtgtatgtgt gtgtgtgttt tc
#tttttctt 216660
ttctttgctg actttcacta ttgatatctg atttgcttgt gtgtttagcg at
#tttatcag 216720
tgagctcata ttctttgaaa ctttagctgt gagaaattta tgtggtttgt gt
#tgaagttg 216780
agttcctcca gcaagtattt ttatttactt ctagttgctt aggagtaata gc
#agctcagg 216840
actacagttt tattttaaat tctgaagtgg aggtttcttc agggtacata ta
#gatatcat 216900
ggatttagtc aacatatgat cataggaata ggcttataat tccaaaacag ca
#tattattt 216960
atttcttttc tatctctcca cccagaggag tggcaacaga gaaagaaggt tt
#cctttctg 217020
tcctctctgc atggtagatt tatttctcac ttcccatttc ctgagaatga at
#gcatcaca 217080
ttgcacaaga ccaggagtta ccattcacat agacttctat ggtacatgca ga
#agaatctg 217140
aagtatcccc tagaattttt cagtataata accctggtta aagttgcatt ct
#ttgggggt 217200
ttcaggtctt tctgcaggga tatcactcat ctttcagcgg gccccagggt tt
#tatagtct 217260
ttctctgaca cactacacat atgttactat acaaatgcaa aggcaccagg at
#taaccaat 217320
ctatggcaag gcaaaactgg ctttagtatc agcttccttc tcaggatttc tg
#tctttgca 217380
ttttgtttac ttgtttgttt ttctgtgact ttttttggcc agtcaccact ga
#attctaac 217440
tttcttttca gcaccacaac ttcttaaaga aaatttattt taatgttata ca
#gagtttta 217500
gttattttaa gtaagatatt cactcagttt agggtatctg ttccaatatt tt
#accggaat 217560
tagaatcttg tatatagttt tgtactcaaa tatacataga aaaccatttt at
#gcataatg 217620
tattcagtat aaaaatgttg ttagatacag aaaactagtg ttttacttaa tg
#atatccca 217680
tattcttggg agatggtttt gctgccaggt cataatatgc aacctcacat cc
#aggagggg 217740
ctccttgcct tgtcacagac cttgctgtcg accaaaacta acctactgat ct
#ttttttca 217800
tattattatt aatgagaagt agaatcaagt tttaaatgtt ttaaaattct ct
#ttcttgca 217860
tctgtgtgtt cttcagtgca agatatgttc ctatagttcc aagtatttta gt
#aaacgtat 217920
catcttataa ctgttattct gtggaatcat agtagcattt tcttttgaat ga
#aaattttt 217980
cttatacagt tgtaagaact ataatttatt tatactttac ttcattcagg at
#atttatta 218040
cgattacatt ctagtgaagg ttcaattgta aataacctag tgcacttcag tg
#acaatttc 218100
agcagaatag atttttagaa tggaattgtt ttatgtatct atatttttgt tt
#ctttcagt 218160
gcctgatagt gcaccagaaa atatcactta caaaaatatt tcttctggag ag
#attgagct 218220
atcattcctt cccccaagta gtcccaatgg aatcataaaa aaatatacaa tt
#tatctcaa 218280
gagaagtaat ggaaatgagg aaagaactat aaatacaacc tctttaaccc aa
#aacattaa 218340
aggtaaaaga acaaatctaa tattggatat ttgcatttat aatgacagag ta
#gccacaaa 218400
tattagttta atgttaatag tttcagatta ttttcatgca gggtattaca at
#tttgtctt 218460
tttggttaaa taagctagga gtttattgca ggtcacatga aagaatacta ta
#gatccatc 218520
cttttccaca ttatcctata tcattttgtc ttcataaata agagctacta tt
#gccaaaga 218580
atgacatttt cacttagttt ttatttttgg aagattgtgt tgacagccat tt
#catagttt 218640
gcctcttgca tattattaaa tgatattttg taagtttcaa cttacctatt tg
#atttctct 218700
ttagtactga agaaatatac ccaatatatc attgaggtgt ctgctagtac ac
#tgaaaggt 218760
gaaggagttc ggagtgctcc cataagtata ctgacggagg aagatggtaa at
#ataatagt 218820
ggatattgat atactttgat tctataacat tccaagaaac acacgtatag aa
#tgaaacaa 218880
tgtaaaaact cctctagtca tgggtatcag ttgtgtacca taccagcgtt at
#acagagat 218940
ttcattgtca tggtataaaa gaagctagca acatcagatt tacattcagt ga
#aatcaggc 219000
ataaaatgtt ttttattttc tgaagtcatc agtactctgt aaaaaacagt ca
#gtcatgtt 219060
tttccatggg gattttcaag gcttaaaatt tggtttgaac gttaactgat at
#atgtcatg 219120
actgagtttt tcaactttta catttttaag aatagacatt aacatgagct tt
#gaagcaga 219180
ttatgtttat gtaaatgttc agcacttttt tacgatatta atgattaact tg
#ataatgag 219240
atcaggctat tgtacaggct tctgcataat tggacaagat gctattcccc aa
#agttagta 219300
gctttcatac tgaatattta aacatacctt tccctaaccc aaataaaatc aa
#ctttacta 219360
ctgaggccac tttacattga taccttacca agttagacat atattatgct aa
#gaatataa 219420
cttctgaaag atatatttgg gttaggattt gcattttatg ttttatacat tg
#catattta 219480
aagaaaatta ttattttttt ctgtaaaagg aattcctatt tccaagaagg gt
#aggcctgg 219540
aagtatcata cgtgtttgtg gagtatcttt tctttttcat ctttctttct tt
#caagtttc 219600
cccatcttca agctaggcca tagcctgtga ctgttaaggg cagaatgtgc tt
#agacactg 219660
ctaggaaggg agacttttcc ctgcattgct ctctttcttt tcaaaataat aa
#agtcttca 219720
aatccctctt ctctttttgc aggtctctcc atgttttaac ctctaccaaa gc
#atcttggc 219780
tagggctgtc tgtgttgccc cagtttctaa gtgggctgcc tctgtgggtc ag
#ttttccct 219840
aatcattgca tctacttact aatgcttgct tttccatcaa aacttacctg cc
#caaattcc 219900
aatttttctt cataaataga ttctccttgc tctgaaagtt aaaattatct ta
#ataaaaaa 219960
accttccaaa tgagtcaatg gttaaaaact agggaagaaa gttagtgctc tt
#ttctatct 220020
tatgtaatac ctaagattat atgtagtaaa aattttacca atgccttttt ga
#aaatagta 220080
cccacttctt tataactaat ctaatcaaaa gttcctaatg gtaagaattt ga
#gatcttat 220140
atgatggaat gagaccagta gtgaacatat attttgagca ggcagacgtt tt
#accactca 220200
agtcaatagt tccaaagtat gttgtgcatc tgaattacct gggctgttaa aa
#atatgctt 220260
cctcaaggta aagttccatc taaattcttg gccaagtcat atgatttcta ag
#gaacaggg 220320
taaagaacaa gactcccttg ttgaaaaatt acagaaaatc gagaatggat aa
#agatctga 220380
gaacatttgc ctctttggga attaggaact ccttgccctc atgaagctca cg
#gttagaac 220440
aagagaccta aatttgacaa atgtgtggac aaataatttt tatgattttt aa
#ttactggt 220500
ataaatgttc ccccaaatta ttcaccagga caaaagaagg acctaagtta ct
#ctggggtg 220560
tgaggtaaag cgtagcggtg gaagttatgt cgaagctgtg acatgaaaat ga
#ataaagag 220620
ggagggtgag aaataggaaa gatcatgcca ggtagaggag tgagagattt gt
#gaagtcct 220680
catgccaggt agaggagtga cagattgtga agtttcttct cagctacctt ga
#gatgctct 220740
gagatgacaa attgaatgca ctgcaaaagt tctaattttt ctagtttcaa tt
#ttgttaga 220800
ttgtatttta gaatacatgt gccaaaatat tttagaatac atatgccaaa at
#gattaaaa 220860
cttagtctgc tacagtggat gtacagtgat ttttttagat agacatgtta at
#tacgttta 220920
cttagcaata aaatgtttta cattaagaat aaaatattcg gagatctact ga
#aggttagc 220980
ttttaaagac accacgcttt atctggtatt ccacataagc atcttaaagc at
#attataga 221040
gtagaaatgg ttagttgcaa catattagtt tctaagttac tgctattttt aa
#ttgaagtc 221100
ctttttgtaa acaataaaca gattttacaa ggatgctagg aaaaatattt at
#aggtattt 221160
gctttgacaa atgaaagaga attttcagag ataattctta tcttgggaaa ca
#gacatctc 221220
taactgatgt atacattcct gtgataatca atatttgata gcaacattat ta
#tagtgcca 221280
gtgaaaataa cagaatgaaa ataccaaata cagctatcac tattattcct ta
#taacttgt 221340
ctcataaact ttctgctgct caataaaatt tttttggaaa attattgtta gt
#taaataat 221400
gaaaacatgc acacatggga acacatacaa ctacagctga gattattcag ag
#aagtaaaa 221460
aagaaaaaat attgaagtaa gtcaggtagc attctgtcca aattattgga aa
#tagtgatc 221520
tgtatatgaa ctgtatttca attgacattg tttaaagatg taaacaaatt ct
#cagaattt 221580
ctgttagcta cctatgaatt cacattcccg tgcataactg taacaatgaa cc
#aaatttta 221640
gtgttttcct tttttacatg taaaaagttg tattccatta ttctaagaca tt
#actgtgtt 221700
attacacagc agctgagaaa tgtcattcta aatgttttac ctaaatggaa at
#ataaagtt 221760
ggctgactat tttgcagtaa tgtttttatt gcttattcaa tgccaaatag ca
#aatgtatt 221820
tatattttac actattacag cagagttaca agtagattct aaactatttt ct
#tatttacg 221880
tgctacattg gcatttcctt tgtaaaccat tcaattttga agactgagtg aa
#cagagttt 221940
gatattattt tactttttaa tgacacaaca gagattgagg aatgtagttt tc
#atcatttg 222000
tgaggtcagt cattttaact gctttctcaa tgttatgctt atcactttcc ca
#acttcttg 222060
gatgtgtgat ttttttccca cctctttttt attgtctagg gatctctttt ac
#tgtatatt 222120
tattcaccct caataaaatt tttattttta ttagaggatg acagttgacc aa
#gatgtact 222180
tgaacagtag gtgagtcact gtgacatacc ccttgttctt ctttctcatg aa
#atattttt 222240
ttccattgaa tcacagaaac agatgttcta ataccaccat gcaaaatctt cc
#tttatcat 222300
ctcattttga aagtaaacag tctcttgtgc ttctggagaa aagcactgaa cc
#taattcct 222360
ttaccagaaa gtttataata aaaattgtgt gcatttccat gttaactttt tc
#ttatatat 222420
gtttaataaa acacattatt ctatacccta actttacagc tcctgattct cc
#ccctcaag 222480
acttctctgt aaaacagttg tctggtgtca cggtgaagtt gtcatggcaa cc
#acccctgg 222540
agccaaatgg aattatcctt tattacacag tttatgtctg gtaataattt tt
#tttttgga 222600
aatagttctg agaacagata ttaatctgta acataatagg aatgtagctt tt
#agatttca 222660
gaatgtggtg ctacattagg aacctgatta ttaataggct agttaatatg tt
#ttgattaa 222720
gaaacaagtt tttccatatt atgtagtggt tcaatcatgg tcaaatgaaa ta
#attttgca 222780
attaaaacaa aaaattatgt gttacgcata attatactaa attcctactc tt
#aaaagtca 222840
ttgacaagtc aatttgtatg aatgtaagca tatactttta cacttcctga ag
#ttttacac 222900
aagtannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 222960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt catgagaact tg
#gtagattg 223020
aaatctttac tttgaatgta atgtaaatcc tctttagatt caccaattag gt
#aacacatt 223080
acctagtgga tttcatatat ttcaactcag aaaatacaat ttacacaata ct
#tcgtaaaa 223140
catagccatt tccttttata tttctgaatt tgaagggcca gcattgaggg ag
#atgccatg 223200
atgttttaaa gaagtctcct cttcttctct ttcctaagtt aagatttttc tt
#tccctaat 223260
tcccctttaa cccctttaca tatttctctt taagactata ttttttgttt tc
#tttgttgc 223320
ctgattccta gtgactttgc ctagtcgtga cgaaagtggg agtgtcttga ct
#cccagtta 223380
gcgaaaagga agcagggaag aaggttacca ttccttttca ttaccctatt ta
#tttattca 223440
ctcattcatt cattgaacaa tattgataga atacctatat actcatgaag aa
#gactcaca 223500
taagaccgtt gccctcaaga gtgttgtatc tcttacactc ccaagagata ac
#tggattat 223560
atacccataa acaagcaaac aagggaatgt tgggggaagg aggtctactt tt
#gatgggat 223620
gcttcaggaa gttctctttg aagaagtgtc attgagctgt gatccagttg ac
#aagaaaga 223680
gcttcttgcc atgtaaaaat ctacagggca gaactttcaa gaaggaggga at
#accaactg 223740
cacaagctct gtggggaaac aaaacttgtc actttgaaga ccagaaagga gg
#tcaatgtt 223800
gctggggatt agagaaccag aggagggtaa cagtggggac aggaaataaa gt
#tcaggagt 223860
caagccatgg taaggatttt gttttcattt taactataaa gggagttcat ag
#ataattta 223920
aatcacttta gattccttat aaagaatgaa ttgtcaggga caaaagtgtt ag
#cagggatg 223980
ctaggctatt ttagtagtct gggaaagaga tggtagtggc aacagagggg ag
#aagtaggt 224040
ggctttgagc tacatttggg aagaaaaact aacaggactt ggtgatggat gg
#ctgtgcag 224100
ataagaaaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 224160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 224220
nnnnnnnnnn nnnnnnnnnt gaatcaagtg tggttactac tagaatttga tg
#gcattgat 224280
taagttagaa aaaaatttaa atgaaacaga ttaagtgaga atcaagattt tt
#ctggctgg 224340
gattttcagc cctgcattat gagaataatt gttttcttct atacagtgat ca
#tgcttccc 224400
ttcctagagc ttccgtgtat atctagcata atgcataaca cacctagaca ga
#aacacatg 224460
tggttggata gcattttaag ggatgccgtt cacccagttt ttctctctct gg
#gtatgaac 224520
tccatgtcaa tgggagcctc ctattctagg aacttagcta taactttagt tg
#tctattta 224580
tnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 224640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tactacagaa ag
#atgagctt 224700
ataaaaagca gtgctaaatt aggccacagg aaaatgcttc cagttaaggg at
#aagtatga 224760
catttccaag ggataataaa gggtaaagat atcttctgga tcctccctca at
#ataacatc 224820
aatatcttct ttgaaccttg aaaataatta aatagagaga agaaaatata ta
#aaacctgt 224880
gtaaatatgt gattttatat aaatgagatg ttcttcctag aggataagaa at
#attggaag 224940
agatttttgc caggaagttt tttcttactg gaagtgtgcc tatttgcaga at
#taaagaac 225000
acgatcagaa ctggaaagca aatactaata gtgtgagtct tacaatgaga aa
#agaaaaaa 225060
aattcttacc tatgtagaag tcaaaataaa agatttgtga tgactatttc at
#gaagaaaa 225120
catagcttaa agaataggca acctttttct aactgacatc tgagtattat at
#aatatagg 225180
tattttctgt caatatgtac acattcagat taattaacat gtcaatatat gc
#tattgggg 225240
ataattaaaa atttttaatg tgctgtaaga aactattgct gataggaagg tg
#atttagtc 225300
aacctagttc tgcttagatc tatttttatg gagcttgaat ttttattcct gt
#gaattctc 225360
ttatttaagg tctattggga agcccttact ctccgtttca tctcacactt ta
#taaatcat 225420
tcttgtgacc tttactctgt tcaaataaat gttagccatt gcagaattcc aa
#agggtatt 225480
tggcatgata catttgatgt cttcagtgta agtaatgtta taggaaaaat cc
#tgttaagt 225540
attttacatg tgctatttca tttagtcctc agcacaatcc tataacatag at
#acattatt 225600
attcccattt taaagacaag ataaatgtta cttacaacag ttaagtaaat tg
#ctcaaagc 225660
tactatctgg gaattggtag aactacagtt aagccaaggt tatgattcca gt
#catggcat 225720
ttgcaaaagc ttgagtctta ttctcattaa tgacattttc tttttctatt ct
#agtctatt 225780
ggaagatatt attcaaatca aattttttta tctttaaaat tctggaattc tt
#agtttaaa 225840
ttattaatta aatgtactta tctaatttat ttttttaaaa cagttttttg ag
#tatttgtt 225900
tgcctgatta gattgtgaac tctaaattaa ggtaccatat acatggtctc tt
#gcatttgt 225960
tacagaaata attgtaatgt cttttatgta gtggatatat cagagaaaga ct
#gagctttc 226020
aaaataaacc caactgcaac tggattcttg ctctaccatt tattcctgtg tg
#accttggg 226080
caaaggtatt tgacctctct cagccagttt tctcatctat acaattttga ca
#ataatact 226140
ttatttgttg attgtataga tatcttcata tttgccttct tccttgagag ta
#ttaaaaaa 226200
gtatctttgg catttatctt atggataagt caaagttttg ttttaaattt ta
#gattctct 226260
tttttcaggg agtaaaatgt ttgaacacaa tccttttggt ctgttctagg tt
#gctgctga 226320
aaacagtgct ggcattggag tgtttagtga tccatttctc ttccaaactg ca
#gaaagtgg 226380
taattttcct gtcatttatt ttaaattgac ttagtcatga gtttgtcgtt ta
#aaataata 226440
aagaacataa ataaaaactg acactaaaat acatataatt ctcagtagca tg
#gccactta 226500
attagtttta gagttctttc ggatagctaa tttattcctt aaaatatata tt
#attctttc 226560
tgattataag aacagtaaat gttatcttac aaaactttga aaaaacaaga at
#aaaaaatg 226620
aaaattatcc atagacttat catataaaaa atgcttttat cattttggtg ca
#tttctggc 226680
ttgtctattt cccccattaa tatgtatcta tatgactata cattaatgaa aa
#taagcttg 226740
tgctacatat gcaagtttat atcctgcctt ttctttttaa catgaagtca ta
#agcttgtt 226800
ataacataag acttttggaa acacggattt taatggttat tatattattg gg
#taacatgc 226860
agtcattacc aaaccaattt aagatacctc cattcttcca ggggcataga gg
#aaaaatct 226920
tgatgtcacc tgtggctctt ttctctcaca gtacacatct aatctatcag ta
#aatcttac 226980
cagcacaatc atcaaagtgt attctgaatc tcacactcat tgctgacatc ct
#gtccaaca 227040
ttattcccaa gaattgttgc attatatttt atttttatta gaatgcagct gt
#cctgaagt 227100
cccttaattc ctaccttata tcattcatat agacctcctt ccaaagatct aa
#ctttctta 227160
tgtaatttat gtggctatta cttataaatt atattttagc atccttttgt ac
#aatgtaaa 227220
cctaaactct agttatttgg catcttaata ctaggcatct ttactatcac tt
#attttttt 227280
tttatctcag acgttttgtt tcattttgat ttctttcaaa aatgacttgt ca
#tgtttgtt 227340
ttatattctg aaggatcttg gtgttttact ctatcagttt tacacacttt ac
#catgaggt 227400
taatgggaat aatttcccct aattctagct tcatattggt ttcaagccaa ct
#caaataga 227460
actcagatta ttattattat tactctatat aattaataat tgatagaaaa gc
#ataatgaa 227520
attctgaagt aagttgattt tgaaaatgta aaatacaata attacaacca at
#tgcagggt 227580
atccacttga tattaggcac tagacattta taaacattcc agaaatctgc tt
#tttggtga 227640
aaatggttgt ataattgatt cagtttgcta tgtttttcat atctaatgaa ac
#tacatatt 227700
ccaaaatagt taaggaaata agaaatttat cccaacttgt ttgtatattc ac
#aactattg 227760
attgaatttt tttcatactt atttgaaacg tttcatcaat gcatgtatta gc
#ccagttat 227820
cctaaagtaa agttgacttg ccccaactcc agttttttat tttaggcaaa gt
#tcagttaa 227880
atacatttat aaaaatctta cacaaataga ttttatgcag tgtattatat at
#ttaatttc 227940
atgtaccatg aaattatata aatgcaattc taagttttat aacaaagttt tt
#tccttccc 228000
aatctttctc ttccccagct ccaggaaaag tggtgaatct cacagttgag gc
#ctacaacg 228060
cttcagcagt taagctgatt tggtatttac ctcggcaacc aaatggcaaa at
#taccagct 228120
tcaagattag tgtcaagcat gccagaagtg ggatagtagt gaaagatgtc tc
#aatcagag 228180
tagaggacat tttgactggg aaattgccag aatgcaatgt aagtatcaca ga
#acactttc 228240
tatgtcttga aaaatcttag ataaatttaa ttttcatatt tctagcatct ag
#atactata 228300
tttttaccaa agttttatta gttatttgat tacttatggt atcatgttat ac
#acaacgtt 228360
ttattatttg attacttagg gtatcatgtt acacaattgg cctcattcag gt
#agaataca 228420
ggaatggttt gagaattcaa gagtgaggga ttaaaatcat ttagggaatt cg
#gaaaagac 228480
ttcatcaaag gagtagcatt tgtgatacac catggagcaa ggacagatag ag
#attttgtg 228540
atggtggcat tcccggtgga ggatacttta taaagccctg aggtggaaaa gt
#gtaagata 228600
taattggaga aaatatttta cttccatatg acaggaggga agagtacatg ta
#gggtaata 228660
gttgaggtta aatttgcaga ggtagactgt cattgttgtg catatctttg gt
#aaagaatt 228720
tgtcgttact ctggtcattg atgataaacc tcataatagt aatgctttat ta
#tagaataa 228780
gcatcgtcat tttaattata tgataagcat aataatgctt ttcctaaaat ca
#ttttggta 228840
atctctgtgt tactattaat gcaaacacag tcaaacagtt atttttgctg ta
#aatacttt 228900
ataaaagtct aaaaatcttc tttttcaact tatgatatag ttctaataca cg
#cacacacc 228960
taacgtgtga gctagtggca tactactact ttttagtact tatgagaaaa aa
#aagttcat 229020
taacagtaag aaagcagcat ttgaacatac acaagagtaa aattatttca gc
#tctttggc 229080
tcttgcactg ttaacatgaa gcttaaaaat tcttacagat gattgtgctg ta
#gttttacc 229140
tttattttaa gccacttgaa attctattcg taaaggttaa ggtataagga at
#acaataaa 229200
tatgtcctct tctaaaactg cagacataaa tgggtacaat taaaatctag ca
#aatttgtc 229260
tataactttt gcatgttatg tgtgtatgta taagcataaa agaaaaagaa at
#gaattaca 229320
tgttcttatt cttatgttca ccaagagata caacattatt tctctattga tc
#ttatttta 229380
tttactagga gaatagtgaa tcttttttat ggagtacagc cagcccttct cc
#aacccttg 229440
gtagagttac acctccatcg cgtaccacac attcatcaag cacgttgaca ca
#gaatgaga 229500
tcagctctgt gtggaaagag cctatcagtt ttgtagtgac acacttgaga cc
#ttatacaa 229560
catatctttt tgaagtttca gctgttacaa ctgaagcagg ttatattgat ag
#tacgattg 229620
tcagaacacc agaatcaggt atggttcact ttttgtagat aaaaagattt aa
#atgattag 229680
agaataatgt ttaatttatg tagatattta attttaatct tctttacctt tc
#agtaactt 229740
ttttccccta ataatatacc ataggcatcc catcaagggt ttcttcgaat tt
#ctatactc 229800
ttttatatta tagcacaaaa taagtatttg aaaggagaaa gatttgcaaa aa
#acaattct 229860
tgagccactg accgtgatcc tcatatagct tttatcattt tataatgtca gc
#aattttta 229920
gtaatcatct ttgccgttct aaatgattta taatcattta cacccttctc tc
#actgttat 229980
tgccatcatc aaaagcagaa atacctgcac tagcagaacg agcatgtgat ca
#acatttag 230040
ttatcagata caagcagtag ctaaaatata tacctactta tatcccattt gc
#actgcagt 230100
ttcctcatct gaaaaataga gacagtaata gtaccttcct tagggtgcca gt
#gttaaaat 230160
taaatgagaa taattagata ttatcattac tactgaattt tatgagaaca ta
#tttttggt 230220
aaggtattca tatatttaat tatggtacta tatcagtatt catgtaaata ca
#tgtattta 230280
tgtatttcat atatttataa aatttaaggg atattgatat agtcccacat ta
#cataaggt 230340
atttattata tatataatat atatagctga cagatatatc ataatatagt at
#caggcatt 230400
aggttgtaat tgctaatttc tgaggtattg aaaattattg gtagggtaat tt
#cactaaag 230460
catgtttttt ctgataaaat agctgttggc ttctattatt tttcatttca ta
#taagtttg 230520
aagttttttt gttcatttaa ataaccatct ttgaattata ccattttctt ct
#tacatact 230580
ccttactttt tatacaataa aaaaatgatt tcggggggag ccaagatggc cg
#aataggaa 230640
cagctccggt ctacagctcc cagcatgagc gatgcagaag acgggtgatt tc
#tgcatttc 230700
catctgaggt accgggttca tctcactagg gagtgccaga cagtgggtgc ag
#gacagtgg 230760
gtgcagcgca ccgtgcgtga gccgaagcag ggcgaggcat tgcctcactc gg
#gaagcgca 230820
aggggtcagg gagttccctt tcctagtcaa agaaaggggt gacagatggc ac
#ctggaaaa 230880
tccagtcact cccacccgaa tactgcgctt ttccgacggg cttaaaaaac gg
#cacaccag 230940
gagattatat cctgcacatg gctcaggggg tcctaccccc acggagtctg cc
#tgattgct 231000
agcacagcag tctgagatca aactgcaagg tggcagcgag gctgggtgag gg
#gcacccgc 231060
cattgcccag gcttgcttag gtaaacaaag cagnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 231960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 232980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 233940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 234960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 235980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnaaaaccaa acaccgcata tt
#ctcactca 236040
taggtgggaa ttgaacaatg agaacacatg gacacaggaa ggggaacatc ac
#actctggg 236100
gactgttgtg gggtgggggc aggggggagg tatagcttta ggagttatac ct
#aatgctaa 236160
atgacgagtt aatgggtgca gcaaaccaac atggcacatg tatacatatg ta
#actaacct 236220
gcacgttgtg cacatgtacc ctaaaactta aagtgtaata ataataaaat tt
#ttaaaaca 236280
atgatttcat aagggtcata caaggtgaaa tttgctagac aataattttg tt
#ttgaaaaa 236340
tatttggaat tgttttattt caattaaaag aataaacatc taagaaaaat ag
#agtaattt 236400
aaaatgtcat tattattttc atgttatcaa tattacattt gaatcctcca aa
#tgtagatt 236460
ataaatttgt tcttagaata aatacaaata ttgatacaaa aagtaaaaat ta
#tttgctca 236520
taattttgag ggtcattttc ttgaaacttc tacctgtgtt aataagagag aa
#aatgttta 236580
tcaagccaga tatccagact ttgttcatcc agactttgtt gaatgcagta ta
#tatatgca 236640
ggtataaatg tttcaagaca atgtaacatt ggcaataaat gtattacaat ga
#atattaga 236700
atgaaacttg cgcagtgcaa tagtaaacag tattaaataa aatcagtaat tg
#ttaaaaat 236760
aagtttatct gatgatccag catgtgttat tcacaatttt caattatatt cc
#atttattc 236820
ttttttaaga taaaaaaact ctgcttttaa gcgcgatatt ttattttcct tc
#tttgcctt 236880
tgtgttttat tatgtgtatt taatagggtg cgctttcatt ttaaatatat gt
#tatgtatt 236940
tattttctat aattatttta gtgcctgaag gaccaccaca aaactgcgta ac
#aggcaaca 237000
tcacaggaaa gtccttttca attttatggg acccaccaac tatagtaaca gg
#gaaattta 237060
gttatagagt tgaattatat ggaccatcag gtaagcctta attggttttg tg
#tttgcctt 237120
ttggagtgag aataataaaa tatgttacca atatcaaact ctgtttaaaa gt
#atcagact 237180
ctttttaaaa gactttaaga ttgaagcaaa caataggaaa gtcataagga ag
#gggaggtc 237240
ctttgatttt ttaattcaaa accataaatg agtataagaa tgacaaaact at
#tcatgttc 237300
cacatttcat gtgatgcatg tgaaaaacta gagataactc ctcaagaaaa aa
#gtgttagt 237360
ggagatatac atcttcaaat atttgaacaa gaagtccttg gcttacattc at
#gaagaaca 237420
atggactttg actatattaa attagatttc tattcactgc taggagccta gt
#ttttaatc 237480
attagaaaga gctctctaaa aataacatgg aaaatctctg tatcttctgc tc
#tattttgc 237540
tgtggaccta aaactgcttt aaaaaagaaa acctattaaa atttttgggc ag
#ctttataa 237600
agtggcaagt tctccaactt tgtaagcaag caggacctgg gcatccactt gc
#cagagata 237660
ctttgagagg atcaagtatt atatcattag gatcaagtat tatatcatta ga
#agtgaatt 237720
atgtaaagtc taaaattctc tcctgattga gagcctctga ttctatgaaa ta
#agtttaat 237780
tctaacaatg atgagataaa taataaagcc acatattatc atttatttgg gg
#gcatcaaa 237840
aaagatacag agttccaact cattttattt tgcaatttct gtggtatgaa tc
#actcatca 237900
ccatcatgag taacctttat ctttcatccc taagtaactt atgctcctaa aa
#ttctgaaa 237960
tacttttact tcctaaaaaa agataattcc ctccactcac ccatccgata ca
#cagaaaca 238020
gacatggata cacagctaca tcttttctgt ctgacattat tgttcaatac tt
#ggctgaag 238080
tactctttca tttgtaaggc tggctgataa atcaagtgag aggcatgtag ca
#ataattgc 238140
atttagcaac atgggagtga tcacatgctt tcagtatggt ggaacatgtg gg
#gtaaatac 238200
atgattgaat tagtttaaga gtgaatggga gaagatcatt ggaacaatgg gt
#gtagaaat 238260
tcttttgagt ttagctgcaa agcaaagcag tgaatagaga gtaagggtag gg
#ataagtga 238320
agtcaacagg tctcttcagt aagaacatat aaagcatgtt tgtttgctga tg
#gaaatgag 238380
gaaaataagg aaaatgttaa tgatataaga aaaacgagaa ttactggaaa gg
#tgtctgtg 238440
tgggcagaag gtgagatctt ttgctcaaat gtagccattg gtttgagata ag
#aatacaga 238500
taatttgtcc atactaacag ataatttgtc cataagttgt tcttataggt tg
#taaggcag 238560
agtatatggg tgtagatgct ggtaaatata tagttgtgtt ggtgggagcc tg
#tggcaaat 238620
attttctaac tggtttacct ttttcagtgt agtgggaagc aagactatta gt
#tgggagtg 238680
aagatagggc agaaggtatt agaggtctga gcagagaaga gtaagtgtaa aa
#taatcttc 238740
tagaagagta gagtgattgg accattgact atgtaagttg agtaagattc ca
#ggcaccat 238800
gtagggctca ttcaaggttt ggctatgaat aaagtgacat caattaatgg ct
#ttgtgctg 238860
taaatgagct gccttcaaca acagaagggc gagggaattg gaggcctgtg ta
#aggcagtg 238920
attataattg aaactgacac tgaagatggg tagagtggaa atcaagtggt ga
#ggggccaa 238980
ataaaataaa acaaaaataa aataggtgat taaatcaatg gattgttgat tt
#cagtggat 239040
ttaaagaatt atcagttcag aattatagag gaaatgtaaa ggaagtaagc aa
#aagtggtt 239100
agaaaaaagt tgcatgaaat tgagattctt aatgatacgg agtaattggt ga
#tagtaatg 239160
tccaagttat gatcttgagg gagtggctga aattctgaaa aactagatta tt
#taaggaaa 239220
tatctaagta atttaaggat taagtctcag gatattaaaa tcagcacaaa tt
#aagatggt 239280
agccttgaac caaagctaga ccatgaaagt aaatgagagt aaatgaccct ca
#ggttagta 239340
gattacgaca actgtgaggg ctagtggatt tcactggtga tacagtattt aa
#agctgtgg 239400
gcttttataa ggagggagag agaatagtaa ataaagtgga gcaatgagga gc
#aaggacaa 239460
cacctaccac acctaaaggc ctggttactt gagagctgtg gggcaaaaac ag
#actgccac 239520
catttggggt ggctgcaggg gaacaaaaac agtgttctca ggaaagagcc ag
#tttgtagt 239580
tagagcaaga aggtaaagga aacatttaaa gcaaagtcga agatttaaag ta
#ttgtgctg 239640
acagactaag gaattttgtt cagaagctaa actagaaata ttttctaaat at
#atcctctt 239700
atagaagata atgaaattat ttagcatttt tttttttttt tttttttttt tt
#ttgagacg 239760
gagtcttgct ctgtcgccca ggctggagtg cagtggcggg atctcggctc ac
#tgcaagct 239820
ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc cgagtagctg gg
#actacagg 239880
cgcccgccac tacgcccggc taattttttg tatttttagt agagacgggg tt
#tcaccgtt 239940
ttagccggga tggtctcgat ctcctgacct cgtgatccgc ccgcctcggc ct
#cccaaagt 240000
tatttagcat tttaattgaa taaatttgag tataaaatct ggtcactttt tg
#aactgata 240060
aaatttgatg cttccctttt caatatgtca aaaataacct ggtaattcaa aa
#aggcttta 240120
tgatttaata aaagtcattt taagcactgg aacattttca tgttctttca tt
#tattttca 240180
ttaaattgat atcagtgcac tactaagcca catgtttaaa atatatgcag tt
#ttgatatt 240240
ataataacaa attttagtgc ataggttaac acttgaattg ttgtctttgg ct
#ctgtactt 240300
aaatgtgaac atgattgcac gcttgataaa aaataatcca tagctatctt cc
#actttttg 240360
caggtcgcat tttggataac agcacaaaag acctcaagtt tgcattcact aa
#cctaacac 240420
catttacaat gtatgatgtc tatattgcgg ctgaaaccag tgcagggact gg
#gcccaagt 240480
caaatatttc agtattcact ccaccagatg gtaagaacat agggaatgag tg
#agatattt 240540
ttggtatgct tatgaacttc atgaattggt aaaacatgat attagaagca at
#ttgtttta 240600
catttactta aatcatgtta tttccttatt aaattactac ctaattcatt ct
#gaacatgt 240660
gttctccaga atgttaaact catagcatgc ttcataataa aagggaccca ag
#atcaggta 240720
aggttaggaa atatcatatg tagtattggc ctgttagaga ttcacaataa aa
#tttagcaa 240780
aacctcaaga agtcataagg taaacaaaca catttagtat ggtttaacta ca
#tttttaaa 240840
tgtggaatct attttttctc acagaactag tatttagaag aattcctata ct
#cccaattc 240900
tttcaacaaa atatgtttat aatcaaaacg ggattctaag caagtgaaga tt
#ctgagtgg 240960
atgtatgata tagatttacc agcatttact gaaattatga aaacattatt tt
#tcctcaag 241020
aaacttcctt ataagtattc attaaacatc attgttttag gtgaactata ct
#ttaaaaag 241080
aatgtttcca tactatttca caacatatct ttcaggccca cactgaactt gc
#taaatgtc 241140
ttaatttcta tttagggatt gtaattatgg acaaaaataa cagtaaattc tt
#ataacaca 241200
ttaacacttg gaaaagtttc cagactttgt ttgtgtggaa gctaacatac ag
#taacttat 241260
aaatgaaatg tagacatgta tacacacaca cacactcaca cacacgcgca ca
#cacacaca 241320
cacacacaca cacaggtcat acattcatcg ttcaagcgtt tgaccattag ag
#ggcagtaa 241380
ctattaggaa attttgtact tctacccttt aaagaaacaa ccattgatat tt
#ttttgaaa 241440
gaacataaaa gttacgtttt atctatttca gatgaaaatc ctgacatata ta
#tagtttta 241500
gaatacatat aagaaagttg tacatactca taaggaaaat gttctttttt tg
#tattaaaa 241560
ttttaccttt gtgtttctat cagaagaatc ctagcattgt gtagcttctt cc
#ttaaatct 241620
taagttttcc tccatctcca cctaaaaact gctcttaagc atgtcctagg aa
#actagaca 241680
gatttatgga cactatcaaa taaagcagag cccttgattt tggtcttaat ag
#agttttct 241740
caaccaactc aatgtaccta ttgatttcta ttcttgttat acaattaaat ac
#atcctgaa 241800
ctattgtctt ctttcaagac cagctgattt tggtgcttcc aaatagaatc ca
#caactcaa 241860
taaacatatt tttattgtca tcattcttgg actacatcat gtgacaaaaa ta
#gggaaata 241920
gataatgcat atgctgtgta caatgtcatg ttatttgtct tggattattt ta
#aaatttac 241980
ttgccttaat ttctacattt tttatccaca aaagaagtag aatcttcagg tc
#atagttca 242040
gtatatttca caaggcctat ttttcacacc aaatcatttt aagtagatga ct
#ccatttgc 242100
cctctataaa aagcaatttg tcctgtgttt cattctgtta tcttcctgag tc
#actcctcc 242160
tatagatcac accctggtgg gtcttagagg ggcctcctgg caactggtgg gt
#tccaccaa 242220
aggcagggtt ggcatggttc ttatatcctc atgtcagcct tcatccatgg ag
#ttctcttg 242280
ggatagttca gccacaggag ctgcctcaat ggaatactct ggcaaatgca gt
#aaatgtag 242340
ctttctactt ctgacaccac taattaatcc tggtttcagt atttaaaact tt
#gaaataaa 242400
tggatcttta aactatatga aaacaatgtg ataactcatt agaactatct tt
#caatttaa 242460
aaatgatttc ttaattttat attatccttt tcattaatac aacagggttt tt
#agtattct 242520
aattaaagtt acttaattta atttcttctc catattttaa accagtctat ca
#tctattta 242580
aaaaataatt aggactagtt tgcttctttt aaattacctt ttaaaacaat tg
#gtgctctt 242640
ataaatctcc agatactcat agaaaaatgt tgcattgacc tcttatagag aa
#tgttatgt 242700
gctattacat tacagtggag ttgatttcat tacccctggg gatgttacgg tc
#catagtct 242760
actttgaaag aaaatcagca tcctattatt ttagcagttc tcttatgtat tt
#cctaagcc 242820
ctctatatgt ctcttaatat tttgatgagt agatttctgc ataggcatga aa
#ataaatga 242880
ttttggaaaa aaaagataat aatctccaaa gctataaaat gtcatagagt tg
#cctattcc 242940
aaaatcagat aatgctgatg aatataacat aggcaacagc attcttctaa at
#tgtgtgag 243000
gggtaaaaaa aataagcaga ctgtgatgct tcaatattgt ctaacaactt tt
#ctgtcagg 243060
gtagtttagc atgaccattt cttaaaagca gacaaatttc tgagattctt gt
#ttactccc 243120
tcttaaacag actatggcag tgaagacgtt tgtcctcagt gatttaaact tg
#ttactttc 243180
tgcaaatagt agtaaaatct ttgcaggaaa ataactgaga gcctgccaac tt
#tgtgtttt 243240
caggatttgc aatggcttta atttttacta cttgtttttc aaaatatact tc
#taaagaaa 243300
ctttaatttg ctagataatg gcaaaaatga tcttaatgta ttttctttta cc
#tcaatgct 243360
gtttgtctct atttcatttc ttctcatagt ttttcatttg aacacttcaa at
#catttgga 243420
atatatttta ataaatcata tgctattgtg tttctaatgc attagtaaaa tt
#tataaata 243480
tattaactcg agaataattc ttaggtagtc catgtatata acaccttcaa aa
#ttaaaatt 243540
attttgccat tatctagaaa attcatcatc gagcagcatt aattttgaag tt
#ggagaaaa 243600
tggcattggg gtaaagaaaa tgtgagattt ttttggccaa atgtctaact ta
#tttctcat 243660
ttatttgtaa aatttgtaaa tgtatcgact tgagaatgac tcttaggtat tt
#cctgtgga 243720
catcaccttc aaaactgatg ctgaaccatg aataattgag ttgtgtgttt ga
#ttttcttt 243780
aggtaatttt gtatcaatat taaagtcttc tctagtttcc ccataagaat tt
#gtggtcta 243840
acagatcaag tatcttttta aagacaagat acaatgctgt tgactccatt tc
#ctttatcc 243900
cctaagctta aataggaaaa aaaagataag tttatagtca ttatttttat gc
#aagtttga 243960
ggtacatttt aaggtaatat agaaccactt aatctttacc tggattgtaa tt
#tttggcat 244020
taagtatcat ggggcaacac ttactaagaa agtaagtatt gaatatatag aa
#tatataga 244080
aatatatatg ctaattaaaa gataaaaaat agtgtctgct actactcttg gt
#ttcactag 244140
caaaataaga gacagtaaaa tatatatagt tttctgctgt cctgcataat at
#ttgatatc 244200
taacacatta gtgtgttgcg ttgacttgaa ctgatcattt cacttatctt tc
#aataggca 244260
gggtttagtt gcctgattaa tatgatcaat gtagtcatta gctgtttttt tt
#ttttcagt 244320
tgagattcta catcagttca aaataaatgg aaaaagtgcc agatctcctc tg
#acttaagt 244380
tatgcaatac tggctattgt tttgtctgca taaaaactgc aaaataaaat tt
#taaaaaga 244440
gatggaatag gagctttgct atttaaatag ccatgttatt ttacaccaca ca
#attaattg 244500
gaaagtttct ccacccttga aaaatgcata ttggtaaatt gcatattggt aa
#atatgatg 244560
atgcaaacat gagctctagg tacaatatat tttagtgaaa taaaactcat ac
#tagaggtg 244620
acctgtgcaa agggctttat ctgtcttatt ccttcctctg tcctcaagtg cc
#tagaacag 244680
tgatcatatg atcaatgctc agtgtgttga atgatgaatg aatggcccaa cg
#attgtcac 244740
aatatctagg gagtctttac cggttacttc atgaagacaa aggaaaaaac tc
#aatctatt 244800
ggatgaaaac tttgtatagt catagttact ataaagccaa cttaagcata at
#tatatttg 244860
ctcattataa ataacatata tgggagttat aaaattattt ttcaattcct tt
#ctgttgtc 244920
ttaaaaagaa agggggtcat ttttcctttg ttccctttta agactatatg cc
#tgtcttct 244980
aactagaatt tgctaaacct gtaccgctgc cagagagttt agggaaatta ac
#tgaaagtg 245040
taacaacaat ctgataataa gggatcataa ttttatgcca ttttctcttt ct
#taaaagtt 245100
ttagaaattt gagaaatttt cttgaactct ttgttcctta tagtaacctg ta
#tagtaata 245160
ggaaagctat aatgacaccc attttataga taaggaaagt agaggttgga gg
#gatgcatg 245220
agctattcat aatcacaagt tgaactgtaa ataaaaatga tcaaaagccc ag
#gggatatt 245280
tgttttttgc ccgttactcc tgtgaaactg ggaagttccc tagatgtcac tc
#ttagtgac 245340
tttacaacta gaacttgctt taagttcttg gtactttatt ttaaaccaat tg
#ttagtttg 245400
ttcctatttt tatttactat tgcaatgagt gagggcacct gaaatttgaa aa
#taacatga 245460
ttatttttaa aatatcagaa aaaaatcaat caactcttca aacaatttca tg
#taataaat 245520
taaaacgcag tctaatttaa cttaccaact atatttaatt gcattcagag tc
#ttctggat 245580
attaattttc aatctgttgt tataattttt atgaaaccat caagatttca ac
#tggcatta 245640
attatcacca aataggcaga ttctcaagaa aattattttt attaattaat tt
#gtttcaaa 245700
caaatgttat gacttttatt ttggaaaatt attctgttat tctgctcctt ac
#ttacattt 245760
cgagaacaat gtttagaaat ttaggcaaga tggccgaata ggaacagctc ca
#gtctacag 245820
ctcccagcgt gaacgacgca gaagacgggt gatttctgca tttccatctg ag
#gtaccggg 245880
ttcatctcac tagggccaga cagtgggcgc aggtcagtgg gtgtgcgcac cg
#tgtgcgag 245940
ccgaagcagg gcgaggcatt gcctcactcg ggaagcgcaa ggggtcaggg ag
#ttcccttt 246000
ccccttgtca aagaaagggg tgatggacgg cacctggaaa atcgggtcac tc
#cgacccga 246060
atactgcgct tttctgacgg gcttaaaaaa cggcgcacca cgagattata tc
#ccacacct 246120
ggctcagagg gtcctacgcc cacggagtct cgctgattgc tagtacagca gt
#ctgagatc 246180
aaactgcaag gcggcagcga agctgggtga ggggcgcccg ccattgccca gg
#cttgctta 246240
ggtaaacaaa gcagcctgga agctccaact gggtggagcc cacaacagct ac
#aaggaggc 246300
ctgcttgctc tgtaggnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 246960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 247980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 248940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 249960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 250980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nn
#nnnnnnnn 251460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncat gtatacatat gt
#aactaacc 251520
tgcacaatgt gcacatgtac cctaaaactt aaagtataat aataaaagga aa
#aaaagaaa 251580
tttagtatta aatatccatg tatttaaaga catttaattt aacaaaaatt ta
#ttatactt 251640
tcagttctgg ggtacatgtg cagaacgtat aggtttgtta cataggtata ca
#tgtgtcat 251700
ggtggtttac tgcacccatc aaagtgtcat ctacattagg tacttctcct aa
#tgctatcc 251760
ctcccctagc cccccaccca ccgacaggcc ccggtgtatg atgttcctct cc
#ctgtgtcc 251820
atgtgttctc attgttcagc tccctcttat gagtgtgaac atgcggtgtt tg
#gttttttg 251880
tccttgtgat agtttgctga gaatgatggt ttccagcttt atccatgtcc ct
#gcaaagga 251940
catgacctca tccttttttt aagacttatt taatttttaa caaaataaat tg
#tttttgtc 252000
tattttcttt ctttcttgtt ttttgtttgt ttgtttgttt gtttgtttgt tt
#tttgatgg 252060
agtctcgctc tttcttccag gctggagtgc agtggtgtaa tctccactca ct
#gtaacctc 252120
cgcctcttgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg ga
#ttacaggc 252180
acgcaccacc atgcctggct aatttttgta ttttttagta gagatggggt tt
#caccatgt 252240
tggtcaggct ggtctcgaac tccttacctc aggtgattgg cctcccttgg cc
#tcccaaag 252300
tgctgggatt acagccatga gccaccgcac ctagcctagt ctgttttcta at
#agaattgt 252360
ttatatatct taaattgtga actaagaatt tagacacttt tttcacttga aa
#aaatattt 252420
ttaaattccc cctttttcct tttctttctt tctttctttc ttagttccag gg
#gcagtgtt 252480
tgatttacaa cttgcagagg tagaatccac gcaagtaaga attacttgga ag
#aaaccacg 252540
acaaccaaat ggaattatta accaataccg agtgaaagtg ctagttccag ag
#acaggaat 252600
aattttggaa aatactttgc tcactggaaa taatgaggta ttgcattttt at
#ttcactta 252660
ttggtgaacc ctttctgctt ggttctggct ctgatagctt ggaagatttg ct
#agcaccca 252720
cacatgtaat atttgaccac ttactagtac aaagtaaagt aaatttgggg ca
#tgttgata 252780
atctagctag atcatatttc attttaggtt atatattatt agttaagtgc ta
#ttattcct 252840
tttcatcata tgaaaaatgt taattgtgca attaaacagg actaaaggta tt
#ttcataag 252900
ttaatattat ttttctaaat tagttaatga attgttcgga aactcttgtt at
#gatttaag 252960
tgctccttca aaggctgtgc ttgcaatttg gaacagttgc cagtgaaagg ca
#cagtaact 253020
ttagtagctg ttgttgacaa atgattctgt tctatttggt cttgggaagc ta
#aatttctc 253080
aaagctgcct cttttttttt ttcaaagtac atttgattaa gagtcacatt ac
#taaataaa 253140
agaaatttaa gtcgtttcat agattttaaa taagaggacc aggatcttta gg
#caatgtgt 253200
ttgcttctat tcacactgga agtcttattt ttttcctttt gtttctgtta gg
#aagtacag 253260
gcaacactga tttttctttc cactgtcttt gttcacctca cttcatcaac tg
#ttcacctg 253320
tgagactctt tcagcctcca ggctagtcat gtccagatac tggctgctcc cc
#ggggcatt 253380
caaagaataa acttccttag gaccagtgca gcaatcactg ggccttaaag ac
#aaacacga 253440
tagttattca gcacctggcg tctgctgtgt tgtttcagaa ttgctgctgc tt
#ctacctgt 253500
gctgttattt tcccccacac atgctttcat tctatttcta gtcccagcct tc
#ctctattt 253560
ctggcactta cctgtatgtg acagttgacc tcaccatgtg ctcaatgcat tc
#tggccacc 253620
caggacttat cactccaagt tgctcaccat cttcaaccca gggttaaatt tt
#aatcctat 253680
gttgattcct ttcctctgtg caaaagatgt tgaattatgc tttctgtgat ac
#tctggttg 253740
acaactcagg caaagggcaa aagcttaacc ctttgctcct gctgagaagg tc
#ttaaatta 253800
gatactgagc tttcctagta ctagatgaca ggtttcccac ttctgctaat ga
#catctgtt 253860
gaatgggtgg ccacacctgt ttttccatga agctaagagg ttctagaaag gc
#tttttttt 253920
tgtgattctg tctctatctg gtctgcaatt ctcgtctcat agtagagagc tc
#atgagctt 253980
tggagacgta caaatttgga tttaaattat gattttgtct ctcactgtgc ta
#tatagcaa 254040
gtggttaaga ctgtaaacca ggtttaaact ctagttctgc cattactaac tg
#tttaaccc 254100
tggaaaagtt ggcctgagct ctctgaacat cagtttcttc ttctctaaga ta
#gtgattat 254160
aagtccctat aacaaagggt taataatgag aatttaatgg gttcatgtgt gt
#aaagagct 254220
tagaactgta cctggcatat agtaagtgct gtgctaaata attgtgacct at
#tgtgatca 254280
ttaatcttgg cataggatca tccaccttag ttgctaccca atattacttc cc
#ttatactc 254340
tctcaatgaa aggagacatt atgctt
#
#          254366
<210> SEQ ID NO 4
<211> LENGTH: 2301
<212> TYPE: PRT
<213> ORGANISM: Rat
<400> SEQUENCE: 4
Met Asp Phe His Phe Ser Phe Leu Phe Leu Le
#u Ile Gly Thr Ser Glu
1               5
#                10
#                15
Ser Gln Val Asp Val Ser Ser Ser Phe Asp Gl
#y Thr Gly Tyr Asp Ile
20
#            25
#            30
Thr Leu Ser Ser Val Ser Ala Thr Thr Tyr Se
#r Ser Pro Val Ser Arg
35
#        40
#        45
Thr Leu Ala Thr Asn Val Thr Lys Pro Gly Pr
#o Pro Val Phe Leu Ala
50
#    55
#    60
Gly Glu Arg Val Gly Ser Ala Gly Ile Leu Le
#u Ser Trp Asn Thr Pro
65
#70
#75
#80
Pro Asn Pro Asn Gly Arg Ile Ile Ser Tyr Va
#l Val Lys Tyr Lys Glu
85
#                90
#                95
Val Cys Pro Trp Met Gln Thr Ala Tyr Thr Ar
#g Ala Arg Ala Lys Pro
100
#           105
#           110
Asp Ser Leu Glu Val Leu Leu Thr Asn Leu As
#n Pro Gly Thr Thr Tyr
115
#       120
#       125
Glu Ile Lys Val Ala Ala Glu Asn Asn Ala Gl
#y Ile Gly Val Phe Ser
130
#   135
#   140
Asp Pro Phe Leu Phe Gln Thr Ala Glu Ser Al
#a Pro Gly Lys Val Val
145                 1
#50                 1
#55                 1
#60
Asn Leu Thr Val Glu Ala Leu Asn Tyr Ser Al
#a Val Asn Leu Ile Trp
165
#               170
#               175
Tyr Leu Pro Arg Gln Pro Asn Gly Lys Ile Th
#r Ser Phe Lys Ile Ser
180
#           185
#           190
Val Lys His Ala Arg Ser Gly Ile Val Val Ly
#s Asp Val Ser Leu Arg
195
#       200
#       205
Val Glu Asp Ile Leu Ser Gly Lys Leu Pro Gl
#u Cys Asn Glu Asn Ser
210
#   215
#   220
Glu Ser Phe Leu Trp Ser Thr Thr Ser Pro Se
#r Pro Thr Leu Gly Arg
225                 2
#30                 2
#35                 2
#40
Val Thr Pro Thr Val Arg Thr Thr Gln Ser Se
#r Ser Thr Ala Ala Arg
245
#               250
#               255
Ser Lys Ile Ser Ser Val Trp Lys Glu Pro Il
#e Ser Phe Val Val Thr
260
#           265
#           270
His Leu Arg Pro Tyr Thr Thr Tyr Leu Phe Gl
#u Val Ser Ala Val Thr
275
#       280
#       285
Thr Glu Ala Gly Tyr Ile Asp Ser Thr Ile Va
#l Arg Thr Pro Glu Ser
290
#   295
#   300
Val Pro Glu Gly Pro Pro Gln Asn Cys Ile Me
#t Gly Asn Val Thr Gly
305                 3
#10                 3
#15                 3
#20
Lys Ala Phe Ser Ile Ser Trp Asp Pro Pro Th
#r Ile Val Thr Gly Lys
325
#               330
#               335
Phe Ser Tyr Arg Val Glu Leu Tyr Gly Pro Se
#r Gly Arg Ile Leu Asp
340
#           345
#           350
Asn Ser Thr Lys Asp Leu Arg Phe Ala Phe Th
#r His Leu Thr Pro Phe
355
#       360
#       365
Thr Met Tyr Asp Val Tyr Val Ala Ala Glu Th
#r Ser Ala Gly Val Gly
370
#   375
#   380
Pro Lys Ser Asn Leu Ser Val Phe Thr Pro Pr
#o Asp Val Pro Gly Ala
385                 3
#90                 3
#95                 4
#00
Val Phe Asp Leu Gln Ile Ala Glu Val Glu Al
#a Thr Glu Ile Arg Ile
405
#               410
#               415
Thr Trp Arg Lys Pro Arg Gln Pro Asn Gly Il
#e Ile Ser Gln Tyr Arg
420
#           425
#           430
Val Lys Val Ser Val Leu Glu Thr Gly Val Va
#l Leu Glu Asn Thr Leu
435
#       440
#       445
Leu Thr Gly Gln Asp Glu Ser Ile Ser Asn Pr
#o Met Ser Pro Glu Ile
450
#   455
#   460
Met Asn Leu Val Asp Pro Met Ile Gly Phe Ty
#r Glu Gly Ser Gly Glu
465                 4
#70                 4
#75                 4
#80
Met Ser Ser Asp Leu His Ser Pro Ala Ser Ph
#e Ile Tyr Asn Ser His
485
#               490
#               495
Pro His Asn Asp Phe Pro Ala Ser Thr Arg Al
#a Glu Glu Gln Ser Ser
500
#           505
#           510
Pro Val Val Thr Thr Arg Asn Gln Tyr Met Th
#r Asp Ile Thr Ala Glu
515
#       520
#       525
Gln Leu Ser Tyr Val Val Arg Arg Leu Val Pr
#o Phe Thr Glu His Thr
530
#   535
#   540
Ile Ser Val Ser Ala Phe Thr Ile Met Gly Gl
#u Gly Pro Pro Thr Val
545                 5
#50                 5
#55                 5
#60
Leu Thr Val Arg Thr Arg Glu Gln Val Pro Se
#r Ser Ile Gln Ile Ile
565
#               570
#               575
Asn Tyr Lys Asn Ile Ser Ser Ser Ser Ile Le
#u Leu Tyr Trp Asp Pro
580
#           585
#           590
Pro Glu Tyr Pro Asn Gly Lys Ile Thr His Ty
#r Thr Ile Tyr Ala Thr
595
#       600
#       605
Glu Leu Asp Thr Asn Arg Ala Phe Gln Met Th
#r Thr Val Asp Asn Ser
610
#   615
#   620
Phe Leu Ile Thr Gly Leu Lys Lys Tyr Thr Ar
#g Tyr Lys Met Arg Val
625                 6
#30                 6
#35                 6
#40
Ala Ala Ser Thr His Val Gly Glu Ser Ser Le
#u Ser Glu Glu Asn Asp
645
#               650
#               655
Ile Phe Val Arg Thr Pro Glu Asp Glu Pro Gl
#u Ser Ser Pro Gln Asp
660
#           665
#           670
Val Gln Val Thr Gly Val Ser Pro Ser Glu Le
#u Arg Leu Lys Trp Ser
675
#       680
#       685
Pro Pro Glu Lys Pro Asn Gly Ile Ile Ile Al
#a Tyr Glu Val Leu Tyr
690
#   695
#   700
Gln Asn Ala Asp Thr Leu Phe Val Lys Asn Th
#r Ser Thr Thr Asp Ile
705                 7
#10                 7
#15                 7
#20
Ile Ile Ser Asp Leu Lys Pro Tyr Thr Leu Ty
#r Asn Ile Ser Ile Arg
725
#               730
#               735
Ser Tyr Thr Arg Leu Gly His Gly Asn Gln Se
#r Ser Ser Leu Leu Ser
740
#           745
#           750
Val Arg Thr Ser Glu Thr Val Pro Asp Ser Al
#a Pro Glu Asn Ile Thr
755
#       760
#       765
Tyr Lys Asn Ile Ser Ser Gly Glu Ile Glu Il
#e Ser Phe Leu Pro Pro
770
#   775
#   780
Arg Ser Pro Asn Gly Ile Ile Gln Lys Tyr Th
#r Ile Tyr Leu Lys Arg
785                 7
#90                 7
#95                 8
#00
Ser Asn Ser His Glu Ala Arg Thr Ile Asn Th
#r Thr Ser Leu Thr Gln
805
#               810
#               815
Thr Ile Gly Gly Leu Lys Lys Tyr Thr His Ty
#r Val Ile Glu Val Ser
820
#           825
#           830
Ala Ser Thr Leu Lys Gly Glu Gly Ile Arg Se
#r Arg Pro Ile Ser Ile
835
#       840
#       845
Leu Thr Glu Glu Asp Ala Pro Asp Ser Pro Pr
#o Gln Asn Phe Ser Val
850
#   855
#   860
Lys Gln Leu Ser Gly Val Thr Val Met Leu Se
#r Trp Gln Pro Pro Leu
865                 8
#70                 8
#75                 8
#80
Glu Pro Asn Gly Ile Ile Leu Tyr Tyr Thr Va
#l Tyr Val Trp Asp Lys
885
#               890
#               895
Ser Ser Leu Arg Ala Ile Asn Ala Thr Glu Al
#a Ser Leu Val Leu Ser
900
#           905
#           910
Asp Leu Asp Tyr Asn Val Asp Tyr Gly Ala Cy
#s Val Thr Ala Ser Thr
915
#       920
#       925
Arg Phe Gly Asp Gly Asn Ala Arg Ser Ser Il
#e Ile Asn Phe Arg Thr
930
#   935
#   940
Pro Glu Gly Glu Pro Ser Asp Pro Pro Asn As
#p Val His Tyr Val Asn
945                 9
#50                 9
#55                 9
#60
Leu Ser Ser Ser Ser Ile Ile Leu Phe Trp Th
#r Pro Pro Val Lys Pro
965
#               970
#               975
Asn Gly Ile Ile Gln Tyr Tyr Ser Val Tyr Ty
#r Gln Asn Thr Ser Gly
980
#           985
#           990
Thr Phe Val Gln Asn Phe Thr Leu Leu Gln Va
#l Thr Lys Glu Ser Asp
995
#       1000
#      1005
Asn Val Thr Val Ser Ala Arg Ile Tyr Arg Le
#u Ala Ile Phe Ser Tyr
1010
#   1015
#  1020
Tyr Thr Phe Trp Leu Thr Ala Ser Thr Ser Va
#l Gly Asn Gly Asn Lys
1025                1030
#                1035
#               1040
Ser Ser Asp Ile Ile His Val Tyr Thr Asp Gl
#n Asp Ile Pro Glu Gly
1045
#               1050
#              1055
Pro Val Gly Asn Leu Thr Phe Glu Ser Ile Se
#r Ser Thr Ala Ile His
1060
#           1065
#          1070
Val Ser Trp Glu Pro Pro Ser Gln Pro Asn Gl
#y Leu Val Phe Tyr Tyr
1075
#       1080
#      1085
Leu Ser Leu Asn Leu Gln Gln Ser Pro Pro Ar
#g His Met Ile Pro Pro
1090
#   1095
#  1100
Leu Val Thr Tyr Glu Asn Ser Ile Asp Phe As
#p Asp Leu Glu Lys Tyr
1105                1110
#                1115
#               1120
Thr Asp Tyr Ile Phe Lys Ile Thr Pro Ser Th
#r Glu Lys Gly Phe Ser
1125
#               1130
#              1135
Glu Thr Tyr Thr Thr Gln Leu His Ile Lys Th
#r Glu Glu Asp Val Pro
1140
#           1145
#          1150
Asp Thr Pro Pro Ile Ile Asn Thr Phe Lys As
#n Leu Ser Ser Thr Ser
1155
#       1160
#      1165
Ile Leu Leu Ser Trp Asp Pro Pro Leu Lys Pr
#o Asn Gly Ala Ile Leu
1170
#   1175
#  1180
Gly Tyr His Leu Thr Leu Gln Gly Pro His Al
#a Asn His Thr Phe Val
1185                1190
#                1195
#               1200
Thr Ser Gly Asn His Ile Val Leu Glu Glu Le
#u Ser Pro Phe Thr Leu
1205
#               1210
#              1215
Tyr Ser Phe Phe Ala Ala Ala Arg Thr Met Ly
#s Gly Leu Gly Pro Ser
1220
#           1225
#          1230
Ser Ile Leu Phe Phe Tyr Thr Asp Glu Ser Al
#a Pro Leu Ala Pro Pro
1235
#       1240
#      1245
Gln Asn Leu Thr Leu Ile Asn Tyr Thr Ser As
#p Phe Val Trp Leu Thr
1250
#   1255
#  1260
Trp Ser Pro Ser Pro Leu Pro Gly Gly Ile Va
#l Lys Val Tyr Ser Phe
1265                1270
#                1275
#               1280
Lys Ile His Glu His Glu Thr Asp Thr Val Ph
#e Tyr Lys Asn Ile Ser
1285
#               1290
#              1295
Gly Leu Gln Thr Asp Ala Lys Leu Glu Gly Le
#u Glu Pro Val Ser Thr
1300
#           1305
#          1310
Tyr Ser Val Ser Val Ser Ala Phe Thr Lys Va
#l Gly Asn Gly Asn Gln
1315
#       1320
#      1325
Tyr Ser Asn Val Val Glu Phe Thr Thr Gln Gl
#u Ser Val Pro Glu Ala
1330
#   1335
#  1340
Val Arg Asn Ile Glu Cys Val Ala Arg Asp Tr
#p Gln Ser Val Ser Val
1345                1350
#                1355
#               1360
Arg Trp Asp Pro Pro Arg Lys Thr Asn Gly Il
#e Ile Ile His Tyr Met
1365
#               1370
#              1375
Ile Thr Val Gly Gly Asn Ser Thr Lys Val Se
#r Pro Arg Asp Pro Thr
1380
#           1385
#          1390
Tyr Thr Phe Thr Lys Leu Leu Pro Asn Thr Se
#r Tyr Val Phe Glu Val
1395
#       1400
#      1405
Arg Ala Ser Thr Ser Ala Gly Glu Gly Asn Gl
#u Ser Arg Cys Asp Ile
1410
#   1415
#  1420
Ser Thr Leu Pro Glu Thr Val Pro Ser Ala Pr
#o Thr Asn Val Ala Phe
1425                1430
#                1435
#               1440
Ser Asn Val Gln Ser Thr Ser Ala Thr Leu Th
#r Trp Thr Lys Pro Asp
1445
#               1450
#              1455
Thr Ile Phe Gly Tyr Phe Gln Asn Tyr Lys Il
#e Thr Thr Gln Leu Arg
1460
#           1465
#          1470
Ala Gln Lys Cys Arg Glu Trp Glu Pro Glu Gl
#u Cys Ile Glu His Gln
1475
#       1480
#      1485
Lys Asp Gln Tyr Leu Tyr Glu Ala Asn Gln Th
#r Glu Glu Thr Val His
1490
#   1495
#  1500
Gly Leu Lys Lys Phe Arg Trp Tyr Arg Phe Gl
#n Val Ala Ala Ser Thr
1505                1510
#                1515
#               1520
Asn Val Gly Tyr Ser Asn Ala Ser Glu Trp Il
#e Ser Thr Gln Thr Leu
1525
#               1530
#              1535
Pro Gly Pro Pro Asp Gly Pro Pro Glu Asn Va
#l His Val Val Ala Thr
1540
#           1545
#          1550
Ser Pro Phe Gly Ile Asn Ile Ser Trp Ser Gl
#u Pro Ala Val Ile Thr
1555
#       1560
#      1565
Gly Pro Thr Phe Tyr Leu Ile Asp Val Lys Se
#r Val Asp Asp Asp Asp
1570
#   1575
#  1580
Phe Asn Ile Ser Phe Leu Lys Ser Asn Glu Gl
#u Asn Lys Thr Thr Glu
1585                1590
#                1595
#               1600
Ile Asn Asn Leu Glu Val Phe Thr Arg Tyr Se
#r Val Val Ile Thr Ala
1605
#               1610
#              1615
Phe Val Gly Asn Val Ser Arg Ala Tyr Thr As
#p Gly Lys Ser Ser Ala
1620
#           1625
#          1630
Glu Val Ile Ile Thr Thr Leu Glu Ser Val Pr
#o Lys Asp Pro Pro Asn
1635
#       1640
#      1645
Asn Met Thr Phe Gln Lys Ile Pro Asp Glu Va
#l Thr Lys Phe Gln Leu
1650
#   1655
#  1660
Thr Phe Leu Pro Pro Ser Gln Pro Asn Gly As
#n Ile Arg Val Tyr Gln
1665                1670
#                1675
#               1680
Ala Leu Val Tyr Arg Glu Asp Asp Pro Thr Al
#a Val Gln Ile His Asn
1685
#               1690
#              1695
Phe Ser Ile Ile Gln Lys Thr Asp Thr Ser Il
#e Ile Ala Met Leu Glu
1700
#           1705
#          1710
Gly Leu Lys Gly Gly His Thr Tyr Asn Ile Se
#r Val Tyr Ala Ile Asn
1715
#       1720
#      1725
Ser Ala Gly Ala Gly Pro Lys Val Gln Met Ar
#g Ile Thr Met Asp Ile
1730
#   1735
#  1740
Lys Ala Pro Ala Arg Pro Lys Ser Lys Pro Il
#e Pro Ile Arg Asp Ala
1745                1750
#                1755
#               1760
Thr Gly Lys Leu Leu Val Thr Ser Thr Thr Il
#e Thr Ile Arg Met Pro
1765
#               1770
#              1775
Ile Cys Tyr Tyr Asn Asp Asp His Gly Pro Il
#e Arg Asn Val Gln Val
1780
#           1785
#          1790
Leu Val Ala Glu Thr Gly Ala Gln Gln Asp Gl
#y Asn Val Thr Lys Trp
1795
#       1800
#      1805
Tyr Asp Ala Tyr Phe Asn Lys Ala Arg Pro Ty
#r Phe Thr Asn Glu Gly
1810
#   1815
#  1820
Phe Pro Asn Pro Pro Cys Ile Glu Gly Lys Th
#r Lys Phe Ser Gly Asn
1825                1830
#                1835
#               1840
Glu Glu Ile Tyr Val Ile Gly Ala Asp Asn Al
#a Cys Met Ile Pro Gly
1845
#               1850
#              1855
Asn Glu Glu Lys Ile Cys Asn Gly Pro Leu Ly
#s Pro Lys Lys Gln Tyr
1860
#           1865
#          1870
Leu Phe Lys Phe Arg Ala Thr Asn Val Met Gl
#y Gln Phe Thr Asp Ser
1875
#       1880
#      1885
Glu Tyr Ser Asp Pro Ile Lys Thr Leu Gly Gl
#u Gly Leu Ser Glu Arg
1890
#   1895
#  1900
Thr Val Glu Ile Ile Leu Ser Val Thr Leu Cy
#s Ile Leu Ser Ile Ile
1905                1910
#                1915
#               1920
Leu Leu Gly Thr Ala Ile Phe Ala Phe Val Ar
#g Ile Arg Gln Lys Gln
1925
#               1930
#              1935
Lys Glu Gly Gly Thr Tyr Ser Pro Arg Asp Al
#a Glu Ile Ile Asp Thr
1940
#           1945
#          1950
Lys Phe Lys Leu Asp Gln Leu Ile Thr Val Al
#a Asp Leu Glu Leu Lys
1955
#       1960
#      1965
Asp Glu Arg Leu Thr Arg Leu Leu Ser Tyr Ar
#g Lys Ser Ile Lys Pro
1970
#   1975
#  1980
Ile Ser Lys Lys Ser Phe Leu Gln His Val Gl
#u Glu Leu Cys Thr Asn
1985                1990
#                1995
#               2000
Ser Asn Leu Lys Phe Gln Glu Glu Phe Ser Gl
#u Leu Pro Lys Phe Leu
2005
#               2010
#              2015
Gln Asp Leu Ser Ser Thr Asp Ala Asp Leu Pr
#o Trp Asn Arg Ala Lys
2020
#           2025
#          2030
Asn Arg Phe Pro Asn Ile Lys Pro Tyr Asn As
#n Asn Arg Val Lys Leu
2035
#       2040
#      2045
Ile Ala Asp Val Ser Leu Pro Gly Ser Asp Ty
#r Ile Asn Ala Ser Tyr
2050
#   2055
#  2060
Val Ser Gly Tyr Leu Cys Pro Asn Glu Phe Il
#e Ala Thr Gln Gly Pro
2065                2070
#                2075
#               2080
Leu Pro Gly Thr Val Gly Asp Phe Trp Arg Me
#t Val Trp Glu Thr Arg
2085
#               2090
#              2095
Thr Lys Thr Leu Val Met Leu Thr Gln Cys Ph
#e Glu Lys Gly Arg Ile
2100
#           2105
#          2110
Arg Cys His Gln Tyr Trp Pro Glu Asp Asn Ly
#s Pro Val Thr Val Phe
2115
#       2120
#      2125
Gly Asp Ile Val Ile Thr Lys Leu Met Glu As
#p Ile Gln Ile Asp Trp
2130
#   2135
#  2140
Thr Ile Arg Asp Leu Lys Ile Glu Arg His Gl
#y Asp Cys Met Thr Val
2145                2150
#                2155
#               2160
Arg Gln Cys Asn Phe Thr Gly Trp Pro Glu Hi
#s Gly Val Pro Glu Asn
2165
#               2170
#              2175
Thr Thr Pro Leu Ile His Phe Val Lys Leu Va
#l Arg Thr Ser Arg Ala
2180
#           2185
#          2190
His Asp Thr Thr Pro Met Val Val His Cys Se
#r Ala Gly Val Gly Arg
2195
#       2200
#      2205
Thr Gly Val Phe Ile Ala Leu Asp His Leu Th
#r Gln His Ile Asn Asn
2210
#   2215
#  2220
His Asp Phe Val Asp Ile Tyr Gly Leu Val Al
#a Glu Leu Arg Ser Glu
2225                2230
#                2235
#               2240
Arg Met Cys Met Val Gln Asn Leu Ala Gln Ty
#r Ile Phe Leu His Gln
2245
#               2250
#              2255
Cys Ile Leu Asp Leu Leu Ser Asn Lys Gly Gl
#y His Gln Pro Val Cys
2260
#           2265
#          2270
Phe Val Asn Tyr Ser Thr Leu Gln Lys Met As
#p Ser Leu Asp Ala Met
2275
#       2280
#      2285
Glu Gly Asp Val Glu Leu Glu Trp Glu Glu Th
#r Thr Met
2290
#   2295
#  2300

Claims

1. An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:(a) a nucleotide sequence that encodes a protein comprising the amino acid sequence of SEQ ID NO:2; (b) a nucleotide sequence consisting of SEQ ID NO:1; and (c) a nucleotide sequence consisting of SEQ ID NO:3.

2. A nucleic acid vector comprising a nucleic acid molecule of claim 1.

3. A host cell containing the vector of claim 2.

4. A process for producing a polypeptide comprising amino acid sequence SEQ ID NO: 2 comprising culturing the host cell of claim 3 under conditions sufficient for the production of said polypeptide, and recovering the polypeptide from the host cell culture.

5. An isolated polynucleotide consisting of a nucleotide sequence set forth in SEQ ID NO:1.

6. An isolated polynucleotide consisting of a nucleotide sequence set forth in SEQ ID NO:3.

7. A vector according to claim 2, wherein said vector is selected from the group consisting of a plasmid, virus, and bacteriophage.

8. A vector according to claim 2, wherein said isolated nucleic acid molecule is inserted into said vector in proper orientation and correct reading frame such that the protein of SEQ ID NO:2 may be expressed by a cell transformed with said vector.

9. A vector according to claim 8, wherein said isolated nucleic acid molecule is operatively linked to a promoter sequence.

10. An isolated nucleic acid molecule consisting of a nucleotide sequence that is completely complementary to a nucleotide sequence of claim 1.

11. An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:(a) a nucleotide sequence that encodes a protein comprising the amino acid sequence of SEQ ID NO:2; and (b) a nucleotide sequence consisting of SEQ ID NO:1.

12. A nucleic acid vector comprising a nucleic molecule of claim 11.

13. A host cell containing the vector of claim 12.

14. A process for producing a polypeptide comprising amino acid sequence SEQ ID NO:2 comprising culturing the host cell of claim 13 under conditions sufficient for the production of said polypeptide, and recovering the polypeptide from the host cell culture.

15. A vector according to claim 12, wherein said vector is selected from the group consisting of a plasmid, virus, and bacteriophage.

16. A vector according to claim 12, wherein said isolated nucleic acid molecule is inserted into said vector in proper orientation and connect reading frame such that the protein of SEQ ID NO:2 may be expressed by a cell transformed with said vector.

17. A vector according to claim 12, wherein said isolated nucleic acid molecule is operatively linked to a promoter sequence.

18. An isolated polynucleotide comprising a nucleotide sequence set forth in SEQ ID NO:1.

19. An isolated nucleic acid molecule comprising a nucleotide sequence that is completely complementary to a nucleotide sequence of claim 11.