1. Technical Field
The present disclose relates to an isolator used in laboratory environment equipment related to regenerative medicine and pharmaceutical production.
2. Description of the Related Art
Patent Literature 1 (Japanese Patent Application Laid-Open Publication No. 2011-177091) discloses a centrifuge provided below a work plate. This centrifuge is covered with an openable and closable cover portion. The cover portion is apart of a work plate and is mounted flash with the work plate.
For example, an operation of opening/closing a cover portion in Patent Literature 1 is conducted by a worker's hands using gloves. However, since the cover portion is mounted flash with a work plate, the operation of opening/closing the cover portion may become difficult. Then, the present disclose is to provide an isolator whose operability is improved.
An isolator attached with gloves in the present disclosure includes:
a work plate provided within the main body case, the work plate having formed therein an opening portion connecting the work space and a device provided below the main body case;
a first cover member mounted to the work plate in a manner openable and closable with respect to the opening portion, the first cover member having formed therein a hole portion into which a worker's finger is to be inserted; and
a second cover member mounted to the first cover member in a manner openable and closable with respect to the hole portion.
Other features of the present invention will become apparent from descriptions of the present specification and of the accompanying drawings.
For more thorough understanding of the present invention and advantages thereof, the following description should be read in conjunction with the accompanying drawings, in which:
At least the following details will become apparent from descriptions of the present specification and of the accompanying drawings.
Hereinafter, embodiments will be described in detail with reference to drawings as necessary. However, more detailed description than necessity may be omitted. For example, the detailed descriptions of matters which have already well known and the repeated descriptions of substantially the same configurations may be omitted. This is because the following description is avoided from being redundant more than necessary, and facilitates the understanding by a person skilled in the art.
Note that the invertors provide the accompanying drawings and the following description to help a person skilled in the art fully understand the present disclosure, and are not intended to limit the subject matters described in the scope of claims thereby.
An isolator system 100 will be described hereinafter as an example of an isolator system in a first embodiment with reference to
The isolator system 100 in the first embodiment is a device configured to perform, for example, work for cell culture, manipulation, observation, etc., in a sterilized environment. Sterilizing refers to an act of killing microorganisms, cells, etc., to bring a state closer to a sterile environment.
Note that, in the present embodiment, the Z-axis is an axis along a vertical direction in which the isolator system 100 is provided to stand, and it is assumed that a direction toward the upper side is +Z-direction and a direction toward the lower side (downward) is −Z-direction. The Y-axis is an axis along a direction perpendicular to the front surface and the back surface of the isolator system 100, and it is assumed that a direction extending from the front surface, where opening portions for conducting work within a work space is provided, to the back surface opposite to the front surface is −Y-direction, and a direction extending from the back surface to the front surface is +Y-direction. The X-axis is an axis along a direction perpendicular to the side surfaces on the left and right sides when seen from the front, and it is assumed that a direction extending from the left side surface to the right side surface when seen from the front is +X-direction, and a direction extending from the right side surface to the left side surface is −X-direction.
The overall configuration of the isolator system 100 will be described with reference to
As illustrated in
As illustrated in
The air conditioning unit 150 is provided above the isolator 110 and is configured to control the air conditioning therewithin. The air conditioning unit 150 includes an intake unit 150a and a discharge unit 150b. The air conditioning unit 150 includes an inlet 151 and an outlet 155 provided on an upper surface plate in the isolator 110. The air is supplied into the isolator 110 from the inlet 151, and is discharged from the outlet 155. In the isolator 110, in order to secure a sterile environment in the interior thereof, a particulate trap filter of a HEPA filter 152 is provided to the inlet 151, and the air is supplied through the particulate trap filter into the isolator 110. A HEPA filter 156 is also provided to the outlet 155, and the gas within the isolator 110 is discharged from the interior of the isolator 110 through the HEPA filter 156. In the isolator 110, a sterilizing substance such as hydrogen peroxide is sprayed thereinto, and thereby sterilizing processing of sterilizing the interior of the isolator 110 is performed.
The control unit 160 is provided above the isolator 110 and the pass box 170, and is configured to control the operations of devices such as the sterilizing unit 140, the air conditioning unit 150, a plurality of diffusion fans 190, which will be described later, and the like.
The pass box 170 is provided on the side surface of the isolator 110 so that a worker puts a work item into the work space A from the outside. In the interior of the pass box 170, a transport space B for temporarily storing the work item is formed. The transport space B has hermeticity against the surrounding environment. Before the work item is put into the work space A from the outside, the work item is sterilized within the transport space B. In the side surface of the pass box 170, an opening for moving the work item is provided, and the isolator 110 and the pass box 170 are fixed so that the opening in the side surface of the pass box 170 is opposed to an opening provided in the side surface of the isolator 110. Thus, the work space A and the transport space B communicate with each other with hermeticity being maintained. A door that is openable and closable is mounted to the opening of the pass box 170. The door can separate the transport space B and the work space A with hermeticity being maintained. The air conditioning unit 180 is provided above the pass box 170 and is configured to control the air conditioning within the transport space B.
As illustrated in
The configuration of the isolator 110 will be described with reference to
As illustrated in
The front surface plate 112 is configured with a glass plate, and the front surface thereof is provided with a plurality of front surface opening portions 113 that are insertion portions for workers' hands. A glove 400 is mounted in each of the plurality of front surface opening portions 113. The front surface plate 112 is openable and closable with a hinge, provided in an upper end portion, as an axis. Thus, the front surface of the isolator 110 can be opened and closed. In the left and right side surface plates, openings for mounting the pass box 170 and the incubator 200 are provided. In the isolator 110, the pass box 170 is mounted to the opening of the right side surface plate, and a door for a delivery opening of the pass box 170 constitutes a part of the right side surface plate. Further, the incubator 200 is mounted to the left opening of the left side surface plate, and a door of the incubator 200 constitutes a part of the left side surface plate. In working, the worker conducts work in the work space A through the gloves. A Hanging bar, on which items used for work are hung, is provided on the upper surface plate.
The configuration of the work platform 111 will be described with reference to
In the work platform 111, a connection opening portion 115 for connecting to a centrifuge unit 120 provided below the work platform 111 and a connection opening portion 116 for connecting to the observation unit 130 provided below the work platform 111 are formed. The work platform 111 is mounted, via a hinge 124, with a cover 123 configured to be openable and closable with respect to the connection opening portion 115 and constitute a part of the work platform 111. The cover 123 is configured to be opened upward and closed through the hinge 124 with the hinge 124 used as an axis. In the cover 123, a hole portion 125 is formed at which a worker hooks his/her finger when opening the cover 123 by pulling it upward. Further, the cover 123 is provided, through a hinge 127, with a cover 126 (also referred to as a “cover member 126”) configured to constitute a part of the work platform 111 and be openable and closable with respect to the hole portion 125. Note that the cover 123 and the cover 126 are provided on substantially the same plane as the work platform 111.
Similarly, the work platform 111 is mounted, via a hinge 135, with a cover 134 configured to constitute a part of the work platform 111 and be openable and closable with respect to the connection opening portion 116. The cover 134 can be opened upward and closed through the hinge 135 with the hinge 135 used as an axis. In the cover 134, a hole portion 136 is formed at which a worker hooks his/her finger when opening the cover 134 by pulling it upward. Further, the cover 134 is provided, via a hinge 138, with a cover 137 (also referred to as a “cover member 137”) configured to constitute a part of the work platform 111 and be openable and closable with respect to the hole portion 136. Note that the cover 134 and the cover 137 are provided on substantially the same plane as the work platform 11.
With this configuration, when using the centrifuge unit 120, a worker hooks his/her finger at the hole portion 125 from the work space A, and opens the cover 123 upward to connect to the centrifuge unit 120. Similarly, when using the observation unit 130, a worker hooks his/her finger at the hole portion 136 from the work space A, opens the cover 134 upward to connect to the observation unit 130, and elevates/lowers the observation device within the observation unit 130 by the elevating mechanism.
The detailed configurations of the cover members 126 and 137 will be described with reference to
As illustrated in
Here,
Further, as illustrated in
An operation of connecting from the work space A to the centrifuge unit 120 by a worker will be described with reference to
First, in an operation of connecting from the work space A to the centrifuge unit 120, a worker is required to pull the cover 123 upward and open it. Thus, as illustrated in
Thereafter, the worker is required to pull out the finger 300 from the hole portion 125. As illustrated in
However, in the isolator 110, the cover 126 is arranged at such a position that the opening width W between the end portion opposite to the pivot axis Ax of the cover 126 and the edge portion of the hole portion 125 becomes greater than three times the thickness of the glove 400. Thus, as illustrated in
Here, an embodiment in which the opening width W is changed will be describedwith reference to Table 1. The glove 400 having a thickness of 0.8 mm is used in the embodiment. In Table 1, “operability” indicates the ease of pulling out the finger 300, “falling problem” indicates a problem of falling of an article used for work and the like, and “evaluation” indicates an evaluation as a product with the operability and the falling problem being taken into consideration.
As illustrated in Table 1, when the opening width W is 2.0 mm, the glove 400 can be pulled out although not smoothly. When the opening width W is equal to or greater than 3.0 mm, the glove 400 can be pulled out smoothly, and when the opening width W is equal to or greater than 4.0 mm, it can be pulled out without awkwardness. As such, the greater the opening width W becomes, the more the operability is improved.
Further, when the opening width W is equal to or smaller than 5.0 mm, problems of falling of an article, etc., hardly occur, but when the opening width W is equal to or greater than 6.0 mm, the possibility of falling of an article, etc., is increased. As such, the reduction in the opening width W reduces the occurrence of the falling problems, and thus is preferable.
According to the results described above, the inventors estimate that, when the glove has a thickness of 0.8 mm, it is preferable from the viewpoint of the operability that the opening width W is equal to or greater than three times the thickness of the glove 400, and it is preferable from the viewpoint of the falling problems that the opening width W is equal to or smaller than 5.0 mm.
As described above, in the present embodiment, an isolator system 100 (an example of the isolator) includes the work space A isolated from the exterior thereof, and includes a substantially box-shaped isolator 110 (an example of a main body case) having a plurality of front surface opening portions 113, to which the gloves 400 for inserting work hands are mounted, formed in the front face thereof. The isolator 110 includes the work platform 111 (an example of a work plate) for conducting work. In the work platform 111, formed is the connection opening portion 115 (an example of the connection opening portion) for connecting from the work space A to, for example, the centrifuge unit 120 provided below the work platform 111. And the work platform 111 includes the cover 123 (an example of a first cover member) which is configured to constitute a part of the work platform 111 and with which the connection opening portion 115 can be opened and closed. In the cover 123, the hole portion 125 (an example of the hole portion) is formed, at which a worker hooks his/her finger to pull the cover 123 up and open it, and the cover 123 is provided, via the hinge 127 (an example of an elastic member), with the cover 126 (an example of a second cover member) which is configured to constitute a part of the work platform 111 and with which the hole portion 125 can be opened and closed. The cover 126 can be pushed downward by a worker with the finger 300, by way of the hinge 127, with the front side of the cover 126 (an example of one end side) as the pivot axis Ax, and when the worker's finger 300 is released, it returns to a position at which the cover constitutes a part of the work platform 111. That is, when the worker's finger 300 is released from the cover 126, the cover 126 returns to substantially the same plane as the cover 123. Moreover, the cover 126 is arranged at least such that the opening width W between the end portion (an example of an other side) on the back side of the cover 126 (an example of the other side) and the edge portion of the hole portion 125 becomes equal to or greater than three times the thickness of the glove 400 mounted to each of the front surface opening portions 113.
Thus, the worker can hook the finger 300 at the hole portion 125 only by pushing the cover 126 downward with the single finger 300, even if his/her hand is inserted into the glove 400. Therefore, the worker can easily open the cover 123 with only the single finger 300. Further, also when pulling out the finger 300 from the hole portion 125, the glove 400 can be restrained from being caught between the hole portion 125 and the cover 126 and not being able to be pulled out. Thus, the isolator system 100 can improve worker's operability.
Further, in the present embodiment, the cover 126 is mounted via the hinge 127 to the cover 123 at least such that the upper surface end portion on the back side of the cover 126 is positioned above the upper surface of the cover 123.
Thus, an article, etc., such as laboratory equipment, a sample, etc., to be used for work can be restrained from rolling over and staying at the upper surface of the cover 126. Therefore, an article, etc., are retrained from falling into the hole portion 125 by mistake, when the worker pushes the cover 126 downward with the finger 300. Therefore, the isolator system 100 can improve worker's operability.
Further, in the present embodiment, the cover 126 is mounted via the hinge 127 to the cover 123 such that the lower surface end portion on the back side of the cover 126 is positioned below the upper surface of the cover 12.
As a result, the cover 126 constituting apart of the work platform 111 does not greatly protrude from the upper surface of the cover 123, and thus an article, etc., such as laboratory equipment and a sample, etc., can be restrained form being caught by the cover 126 during the work on the work platform 111.
Therefore, the isolator system 100 can improve worker's operability. Further, in the present embodiment, the lower surfaces of the cover 123 and the cover 126 are provided with the bolts 128a which are configured to restrain the rotational movement of the cover 126 with respect to the cover 123. Here, in the present embodiment, the bolts 128a are provided to each of the lower surfaces of the cover 123 and the cover 126, but a restraint portion configured to restrain the rotational movement of the cover 126 with respect to the cover 123 may be provided to at least one of the cover 123 and the cover 126.
Thus, the cover 126 pushed downward via the hinge 127 is stopped at the predetermined position by a restraint portion provided to the lower surface. In the present embodiment, the bolts 128a provided to the lower surface of the cover 123 and the bolts 128a provided to the lower surface of the cover 126 abut against each other, and the cover 126 is stopped at the predetermined angle with respect to the cover 123. Thus, a worker can securely apply a force to the upper surface of the cover 126 with a finger. In the present embodiment, the cover 126 is stopped at a position forming an acute angle of about 60 degrees with respect to the cover 123, but the acute angle with respect to the cover 123 is effective if it is smaller than about 90 degrees. The acute angle with respect to the cover 123 is more effective when it is equal to or greater than 45 degrees and equal to or smaller than 75 degrees.
Further, in the present embodiment, the bolts 128a also serve as the parts for fixing the hinge 127 to the lower surfaces of the cover 123 and the cover 126.
Thus, a restraint portion for restraining the rotational movement of the cover 126 with respect to the cover 123 is not separately provided, and thus design is facilitated and also there is an advantage in costs. It is effective if a restraint portion configured to restrain the rotational movement of the cover 126 with respect to the cover 123 and a part for fixing the hinge 127 to the lower surfaces of the cover 123 and the cover 126 are a bolt and a nut. This is because design is facilitated and also there is an advantage in costs.
As described above, the first embodiment has been described as exemplification of technologies disclosed in the present application. However, technologies in the present disclosure are not limited thereto, and can be applied to embodiments to which modification, replacement, addition, omission and/or the like is made as necessary. Further, it is also possible to provide new embodiments by combining the constituent elements described in the above first embodiment.
Thus, another embodiment will be exemplified, hereinafter.
In the present embodiment, the hinge 127 and the hinge 138 are described as examples of an elastic member. However, technologies in the present disclosure are not limited thereto. The elastic member may only be such that the cover 126 can be pushed downward by a worker with the finger 300 with one end side of the cover 126 as the pivot axis Ax and that the cover 126 can return to a position at which it constitutes a part of the work platform 111 when being released from the worker's finger 300. Thus, a high elastic member such as rubber having a restoring force, synthetic resins, etc., may be used as an elastic member.
Further, the cover 126 and the hole portion 125 (first embodiment) are not limited to those formed substantially in a circular shape as illustrated in
The cover 126 in
Further, the cover 126 (first embodiment) is not limited to such a cover as to be formed of a flat plate shape as illustrated in
The cover 126B (
The cover 126C (
Further, in the first embodiment, it has been described that rotational movement of the mounting portions 127a is restrained with the restricting portion S (
The stopper 126D (
For example, when a force exerted onto the cover 126 from above downward is removed, the upper end portion of the third bent piece 126G comes into contact with the back surface of the cover 123, and thereby the mounting portion 127a is restrained from moving rotationally. Note that, it becomes possible to adjust relative positions of the cover 126 and the cover 123 when a force exerted onto the cover 126 from above downward has been removed, by adjusting the length in the Z-axis direction of the third bent piece 126G. For example, the length in the Z-axis direction of the third bent piece 126G may be adjusted such that the cover 126 and the cover 123 are provided on substantially the same plane, the length in the Z-axis direction of the third bent piece 126G may be adjusted such that the cover 126 is provided above the cover 123, and the length in the Z-axis direction of the third bent piece 126G may be adjusted such that the cover 126 is provided below the cover 123. Thus, the cover 126 and the cover 123 are to be provided on substantially the same plane, as illustrated in
As described above, the embodiments have been described as exemplification of the technologies in the present disclosure. Accordingly, the accompanying drawings and the detailed description have been provided.
Hence, the constituent elements described in the accompanying drawings and the detailed description may include not only constituent elements required for solving the problems, but also constituent elements not required for solving the problems, in order to exemplify the above technologies. Thus, even when those constituent elements not required are described in the accompanying drawings and the detailed description, it should not be immediately recognized that those constituent elements not required should be requirements.
Further, since the embodiments described above are to exemplify the technologies in the present disclosure, various types of modification, replacement, addition, omission and/or the like can be made in the scope of claims or in the scope equivalent thereto.
The present disclosure can be applied to laboratory environment equipment in which work is conducted with worker's hands being inserted into a box-shaped laboratory environment.
Number | Date | Country | Kind |
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2013-071696 | Mar 2013 | JP | national |
This is a continuation application of International Patent Application No. PCT/JP2014/001725 filed Mar. 25, 2014, which claims the benefit of priority to Japanese Patent Application No. 2013-071696 filed Mar. 29, 2013. The full contents of the International Patent Application are incorporated herein by reference.
Number | Date | Country | |
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Parent | PCT/JP2014/001725 | Mar 2014 | US |
Child | 14666115 | US |